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https://www.readbyqxmd.com/read/28545737/microrna-146a-governs-fibroblast-activation-and-joint-pathology-in-arthritis
#1
Victoria Saferding, Antonia Puchner, Eliana Goncalves-Alves, Melanie Hofmann, Michael Bonelli, Julia S Brunner, Emine Sahin, Birgit Niederreiter, Silvia Hayer, Hans P Kiener, Elisa Einwallner, Ramzi Nehmar, Raphael Carapito, Philippe Georgel, Marije I Koenders, Mark Boldin, Gernot Schabbauer, Mariola Kurowska-Stolarska, Günter Steiner, Josef S Smolen, Kurt Redlich, Stephan Blüml
Synovial fibroblasts are key cells orchestrating the inflammatory response in arthritis. Here we demonstrate that loss of miR-146a, a key epigenetic regulator of the innate immune response, leads to increased joint destruction in a TNF-driven model of arthritis by specifically regulating the behavior of synovial fibroblasts. Absence of miR-146a in synovial fibroblasts display a highly deregulated gene expression pattern and enhanced proliferation in vitro and in vivo. Deficiency of miR-146a induces deregulation of tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) in synovial fibroblasts, leading to increased proliferation...
May 22, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28541262/joint-espghan-naspghan-guidelines-for-the-management-of-helicobacter-pylori-in-children-and-adolescents-update-2016
#2
Nicola L Jones, Sibylle Koletzko, Karen Goodman, Patrick Bontems, Samy Cadranel, Thomas Casswall, Steve Czinn, Benjamin D Gold, Jeannette Guarner, Yoram Elitsur, Matjaž Homan, Nicolas Kalach, Michal Kori, Armando Madrazo, Francis Megraud, Alexandra Papadopoulou, Marion Rowland
BACKGROUND: Because of the changing epidemiology of Helicobacter pylori infection and low efficacy of currently recommended therapies, an update of the European Society for Paediatric Gastroenterology Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition recommendations for the diagnosis and management of H pylori infection in children and adolescents is required. METHODS: A systematic review of the literature (time period: 2009-2014) was performed...
June 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28538064/temporomandibular-joint-ankylosis-after-early-mandibular-distraction-osteogenesis-a-new-syndrome
#3
Manlio Galié, Valentina Candotto, Giovanni Elia, Luigi C Clauser
Distraction osteogenesis (DO) has been one of the most innovative concepts in cranio-maxillofacial syndromology and surgery over the last 25 years.Early mandibular distraction in severe micrognathia has recently been recognized as an effective treatment option to safely relieve upper airway obstruction associated with mandibular deficiency.An increased incidence in temporomandibular joint complications during DO in neonates has recently been reported, especially in syndromic patients.The authors report 2 children affected by severe micrognathia and severe respiratory distress at birth...
May 19, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28535941/-anesthetic-management-of-two-patients-with-alkaptonuric-ochronosis-for-total-knee-arthroplasty
#4
Betul Kozanhan
The current case report describes two cases of alkaptonuric ochronosis for anesthetic management. Alkaptonuria is a rare genetic orphan disease of tyrosine metabolism characterized by an accumulation of homogentisic acid in cartilage and connective tissues. Patients present most commonly for orthopedic joint surgery due to progressive arthropathy that can be misdiagnosed many a times. However respiratory, airway, cardiovascular and genitourinary systems complications can occur with age progressing. Restricted range of motion of cervical spine may lead to difficulty with airway management...
May 20, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28530471/structure-function-relationships-of-temporomandibular-retrodiscal-tissue
#5
M C Coombs, J M Petersen, G J Wright, S H Lu, B J Damon, H Yao
It is estimated that 2% to 4% of the US population will seek treatment for temporomandibular joint (TMJ) symptoms, typically occurring with anterior disc displacement. The temporomandibular retrodiscal tissue (RDT) has been postulated to restrict pathologic disc displacement. To elucidate RDT function, understanding regional RDT biomechanics and ultrastructure is required. No prior biomechanical analysis has determined regional variations in RDT properties or associated biomechanical outcomes with regional variations in collagen and elastin organization...
June 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28529606/comparison-of-prognostic-nomograms-based-on-different-nodal-staging-systems-in-patients-with-resected-gastric-cancer
#6
Zi-Xian Wang, Miao-Zhen Qiu, Yu-Ming Jiang, Zhi-Wei Zhou, Guo-Xin Li, Rui-Hua Xu
Purpose: Previous studies addressing the optimal nodal staging system in patients with resected gastric cancer have shown inconsistent results, and the optimal system for development of prognostic nomograms remains unclear. In this study, we compared prognostic nomograms based on the metastatic lymph node (MLN) count, lymph node ratio (LNR), and log odds of metastatic lymph nodes (LODDS) to predict the 5-year overall survival in patients with resected gastric cancer. Methods: We analysed 15,320 patients with resected gastric cancer in the Surveillance, Epidemiology, and End Results (SEER) database between 1988 and 2010...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28523982/caffeine-intake-and-meni%C3%A3-re-s-disease-is-there-relationship
#7
Inés Sánchez-Sellero, Elena San-Román-Rodríguez, Sofía Santos-Pérez, Marcos Rossi-Izquierdo, Andrés Soto-Varela
OBJECTIVES: Although it is commonly recognized that dietary restrictions may improve the clinical course of Menière's disease, their effectiveness has not been definitely demonstrated. The aim of this study was to examine whether caffeine consumption could be involved in Menière's disease. METHODS: Cross-sectional, observational, case-control study, comparing caffeine consumption (intake of coffee, tea, kola-type beverages, energy drinks, and chocolate-containing beverages or foods) between patients with Menière's disease (group A) and patients affected by vertigo with other origins (group B) and/or control subjects (group C)...
May 19, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28523427/-total-ankle-arthroplasty-with-simultaneous-subtalar-fusion
#8
J Mainzer, P Rippstein
OBJECTIVE: Pain free weight bearing ability with orthograde hindfoot position and preserved tibiotalar motion. INDICATIONS: Symptomatic arthritis of the ankle and subtalar joint, additional subtalar hindfoot malalignment. CONTRAINDICATIONS: Absolute: acute infection, noncorrectable ligamentous instability or bony defects, restricted perfusion, diabetic foot syndrome. Relative: inability to comply with postoperative partial weight bearing, only moderate symptoms of subtalar arthritis, smoking, intricate soft tissue situation...
May 18, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28520893/using-bayesian-modeling-in-frequentist-adaptive-enrichment-designs
#9
Noah Simon, Richard Simon
Our increased understanding of the mechanistic heterogeneity of diseases has pushed the development of targeted therapeutics. We do not expect all patients with a given disease to benefit from a targeted drug; only those in the target population. That is, those with sufficient dysregulation in the biomolecular pathway targeted by treatment. However, due to complexity of the pathway, and/or technical issues with our characterizing assay, it is often hard to characterize the target population until well into large-scale clinical trials...
May 17, 2017: Biostatistics
https://www.readbyqxmd.com/read/28507969/core-decompression-with-synthetic-grafting-as-a-joint-preservation-strategy-in-humeral-avascular-necrosis-due-to-sickle-cell-anemia-a-case-report
#10
Andrew M Steffensmeier, Karen Kirkham, John M Wiemann
INTRODUCTION: Avascular necrosis (AVN) of the femoral or humeral heads in patients with sickle cell anemia is a common and painful condition. There is currently no gold standard treatment protocol for this condition. Typically, the pain is managed with narcotics and activity restriction until there has been collapse of the subchondral bone with a degree of arthrosis sufficient to warrant total joint arthroplasty. This method entails prolonged pain for the patient and decreases the ability to function occupationally and recreationally...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28507961/total-hip-arthroplasty-indicated-for-a-tuberculous-coxitis-complicating-a-controlled-acquired-imunodefficiency-syndrom-condition-a-preliminary-report-concerning-a-case
#11
Handy Eone Daniel, Jean Emile Bayiha, Théophyle Chunteng Nana, Olivier Kennedy Muluem, Jean Bahebeck
INTRODUCTION: Total hip arthroplasty (THA) remains controversial in active tuberculosis (TB) infection because of the risks of septic loosening and reactivation of the infection. We present a rare case of THA in a patient positive for the human immunodeficiency virus (HIV) with active tuberculous coxitis. The aim of this work is to share our experience and our preliminary results. CASE REPORT: The patient was a 53-year-old Black African woman, positive for the HIV, who was operated for implantation of a THA via the Hardinge approach indicated for a severe painful hip with restriction of joint movement and limp...
November 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28500795/the-future-distribution-of-river-fish-the-complex-interplay-of-climate-and-land-use-changes-species-dispersal-and-movement-barriers
#12
Johannes Radinger, Franz Essl, Franz Hölker, Pavel Horký, Ondřej Slavík, Christian Wolter
The future distribution of river fishes will be jointly affected by climate and land use changes forcing species to move in space. However, little is known if fish species will be able to keep pace with predicted climate and land use-driven habitat shifts, in particular in fragmented river networks. In this study, we coupled species distribution models (step-wise boosted regression trees) of 17 fish species with species-specific models of their dispersal (fish dispersal model FIDIMO) in the European River Elbe catchment...
May 13, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28499954/systematic-review-and-meta-analysis-of-gait-mechanics-in-young-and-older-adults
#13
Katherine A Boyer, Russell T Johnson, Jacob J Banks, Carl Jewell, Jocelyn F Hafer
BACKGROUND: Age-related gait changes may play a critical role in functional limitations of older adults. Despite sizable interest in determining how age alters walking mechanics, small sample sizes and varied outcome measures have precluded a comprehensive understanding of the impact of age on lower extremity joint kinematics and kinetics. OBJECTIVE: The aim of this study was to perform a systematic review and meta-analysis of the aging gait mechanics literature...
May 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28484283/predicting-influenza-antigenicity-from-hemagglutintin-sequence-data-based-on-a-joint-random-forest-method
#14
Yuhua Yao, Xianhong Li, Bo Liao, Li Huang, Pingan He, Fayou Wang, Jiasheng Yang, Hailiang Sun, Yulong Zhao, Jialiang Yang
Timely identification of emerging antigenic variants is critical to influenza vaccine design. The accuracy of a sequence-based antigenic prediction method relies on the choice of amino acids substitution matrices. In this study, we first compared a comprehensive 95 substitution matrices reflecting various amino acids properties in predicting the antigenicity of influenza viruses by a random forest model. We then proposed a novel algorithm called joint random forest regression (JRFR) to jointly consider top substitution matrices...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476391/rate-of-revision-after-cheilectomy-versus-decompression-osteotomy-in-early-stage-hallux-rigidus
#15
Benjamin Cullen, Alexandria Lila Stern, Glenn Weinraub
Two commonly used procedures for early stage hallux rigidus are cheilectomy and decompression metatarsal osteotomy. However, although both procedures were first described several decades ago, a deficit exists in the published data comparing their effectiveness. We performed a retrospective comparative study to examine the results of surgical treatment of early-stage hallux rigidus. A total of 423 subjects were included. Hallux limitus or rigidus had been diagnosed in all patients, who had undergone either cheilectomy or any variation of plantarflexion decompression metatarsal head osteotomy...
May 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28473283/hip-knee-and-ankle-kinematics-during-activities-of-daily-living-a-cross-sectional-study
#16
Kashitaro Hyodo, Tadashi Masuda, Junya Aizawa, Tetsuya Jinno, Sadao Morita
BACKGROUND: Joint angle data from healthy subjects are necessary as baseline information. OBJECTIVE: To analyze the problems of patients who struggle with activities of daily living (ADL) due to restricted range of motion and to provide ADL guidance based on objective data. METHOD: An electromagnetic three-dimensional tracking system (FASTRAK) was used to quantify the hip, knee, and ankle angles of the dominant leg of 26 healthy adults as they performed 22 ADLs related to dressing, using the toilet, bathing, picking up objects, and crouching...
April 9, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28466201/edible-wild-plants-growing-in-contaminated-floodplains-implications-for-the-issuance-of-tribal-consumption-advisories-within-the-grand-lake-watershed-of-northeastern-oklahoma-usa
#17
Ean M Garvin, Cas F Bridge, Meredith S Garvin
Metal releases from the Tri-State Mining District (TSMD) that is located in southwestern Missouri, southeastern Kansas, and northeastern Oklahoma, have contaminated floodplain soils within the Neosho and Spring river watersheds of the Grand Lake watershed. Since the Oklahoma portion of the watershed lies within ten tribal jurisdictions, the potential accumulation of metals within plant species that are gathered and consumed by tribal members, as well as the resulting metal exposure risks to tribal human health, was a warranted concern for further investigation...
May 2, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28462565/prophylactic-kinesio-taping-enhances-balance-for-healthy-collegiate-players
#18
Hsiao-Yun Chang, Yu-Hui Huang, Shih-Chung Cheng, Chun-Yu Yeh, Chun-Hou Wang
BACKGROUND: This study was to investigate the effects of prophylactic Kinesio taping and athletic taping on the functional performance of the lower extremities in healthy collegiate players with tapes applied to the dominant leg. METHODS: The study design was a prospective, randomized, clinical trial with comparison of groups. The 32 healthy collegiate players who participated in this study were randomly assigned to 2 groups, an athletic taping group and a Kinesio taping group...
April 28, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28452626/swimming-against-the-tide-a-case-study-on-the-removal-of-conservatorship-and-guardianship
#19
Kyle S Page, Kate L M Hinrichs
OBJECTIVE: This article evaluates the role healthcare providers play in balancing safety versus autonomy among elders when performing capacity evaluations. METHODS: Presentation of a case study consisting of an 85-year-old, Caucasian, widowed, male, post-stroke veteran, residing in long-term care. He was assigned a permanent court-appointed joint guardian and conservator, but wanted to remove both of these as he felt he had the ability to manage his own affairs...
January 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/28449202/barn-owls-maximize-head-rotations-by-a-combination-of-yawing-and-rolling-in-functionally-diverse-regions-of-the-neck
#20
Markus Krings, John A Nyakatura, Mark L L M Boumans, Martin S Fischer, Hermann Wagner
Owls are known for their outstanding neck mobility: these birds can rotate their heads more than 270°. The anatomical basis of this extraordinary neck rotation ability is not well understood. We used X-ray fluoroscopy of living owls as well as forced neck rotations in dead specimens and computer tomographic (CT) reconstructions to study how the individual cervical joints contribute to head rotation in barn owls (Tyto furcata pratincola). The X-ray data showed the natural posture of the neck, and the reconstructions of the CT-scans provided the shapes of the individual vertebrae...
April 27, 2017: Journal of Anatomy
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