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https://www.readbyqxmd.com/read/29040396/survival-analysis-with-time-dependent-covariates-subject-to-missing-data-or-measurement-error-multiple-imputation-for-joint-modeling-mijm
#1
Margarita Moreno-Betancur, John B Carlin, Samuel L Brilleman, Stephanie K Tanamas, Anna Peeters, Rory Wolfe
Modern epidemiological studies collect data on time-varying individual-specific characteristics, such as body mass index and blood pressure. Incorporation of such time-dependent covariates in time-to-event models is of great interest, but raises some challenges. Of specific concern are measurement error, and the non-synchronous updating of covariates across individuals, due for example to missing data. It is well known that in the presence of either of these issues the last observation carried forward (LOCF) approach traditionally used leads to bias...
October 12, 2017: Biostatistics
https://www.readbyqxmd.com/read/29039501/isoimperatorin-ameliorates-osteoarthritis-by-downregulating-the-mammalian-target-of-rapamycin-c1-signaling-pathway
#2
Jiayao Ouyang, Huaji Jiang, Hang Fang, Wenbo Cui, Daozhang Cai
Osteoarthritis (OA) is the most common disease of the joints, and is characterized by the breakdown of cartilage and degradation of the extracellular matrix. OA causes a high level of patient suffering and incurs large societal costs; however, the current strategies for treating OA are restricted due to limited understanding of the underlying molecular and cellular mechanisms. In the present study, the beneficial effects of isoimperatorin (Iso) were investigated using an experimental mouse model of OA, and its mechanism of action on primary chondrocytes was elucidated...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29037924/-all-inside-arthroscopic-treatment-of-tillaux-chaput-fractures-clinical-experience-and-outcomes-analysis
#3
Shi-Ming Feng, Qing-Qing Sun, Ai-Guo Wang, Cheng-Kun Li
We investigated all-inside ankle arthroscopy for Tillaux-Chaput fractures. We retrospectively evaluated 19 patients (12 males [63.2%] and 7 [36.8%] females; 11 right [57.9%] and 8 left [42.1%] ankles) treated from May 2013 to January 2016. Their mean age was 28.1 (range 10 to 55) years. Sixteen (84.2%) had single Tillaux-Chaput fractures and 3 (15.8%) had combined proximal fibular fractures; 17 (89.5%) were diagnosed radiographically and 2 (10.5%) by computed tomography. Anterolateral and anteromedial ankle arthroscopy was used for closed reduction and internal fixation with 1 or 2 Herbert screws...
October 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29037653/adolescent-idiopathic-scoliosis-the-tethered-spine-iii-is-fascial-spiral-the-key
#4
Lucy Whyte Ferguson
This article reports on an observational and treatment case series involving 22 adolescents and preadolescents treated over a 15 year period who had or appeared to be developing idiopathic scoliosis (IS). Common patterns of muscle and fascial asymmetry were observed and treated. Most of these individuals had spinal area pain and the trigger points (TrPs) apparently responsible for this pain were located in muscles at some distance from the spine, yet referred pain to locations throughout the thoracolumbar spine...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29035322/analysis-of-genetic-diversity-and-structure-pattern-of-indigofera-pseudotinctoria-in-karst-habitats-of-the-wushan-mountains-using-aflp-markers
#5
Yan Fan, Chenglin Zhang, Wendan Wu, Wei He, Li Zhang, Xiao Ma
Indigofera pseudotinctoria Mats is an agronomically and economically important perennial legume shrub with a high forage yield, protein content and strong adaptability, which is subject to natural habitat fragmentation and serious human disturbance. Until now, our knowledge of the genetic relationships and intraspecific genetic diversity for its wild collections is still poor, especially at small spatial scales. Here amplified fragment length polymorphism (AFLP) technology was employed for analysis of genetic diversity, differentiation, and structure of 364 genotypes of I...
October 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29033668/integrative-research-identifies-71-new-plant-species-records-in-the-state-of-rio-grande-do-norte-brazil-and-enhances-a-small-herbarium-collection-during-a-funding-shortage
#6
Leonardo M Versieux, Nállarett Dávila, Geadelande C Delgado, Valdeci F de Sousa, Edweslley Otaviano de Moura, Tarciso Filgueiras, Marccus V Alves, Eric Carvalho, Daniel Piotto, Rafaela C Forzza, Alice Calvente, Jomar G Jardim
A National Forest Inventory (NFI) encompassing the entire territory of Brazil is in progress. It is coordinated and promoted by the Brazilian Forest Service of the Ministry of Environment. In each state, the NFI collaborates with local herbaria by receiving collected plant material and performing species identification. Consultants are hired by the NFI and work at the local herbaria under the supervision of a curator. In exchange for curatorial assistance, the NFI provides equipment and consumables for the herbarium...
2017: PhytoKeys
https://www.readbyqxmd.com/read/29030281/disc-repositioning-plus-temporal-eminectomy-for-temporomandibular-joint-internal-derangement-a-pilot-study
#7
René Pedraza-Alarcon, Martín Pinzón-Navarro, Cristián E Bachelet, Perla Villamor
INTRODUCTION: Temporomandibular joint internal derangement is a common disorder, which usually resolves with conservative management. However, 5% of patients require surgery, and although many techniques have been described, a gold standard surgical procedure has not yet been established. OBJECTIVES: The aim of this study was to compare the clinical outcome of disc repositioning plus temporal eminectomy versus disc repositioning alone, for the treatment of temporomandibular joint internal derangement...
October 10, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29024567/subchondral-bone-plate-sclerosis-during-late-osteoarthritis-is-caused-by-loading-induced-reduction-in-sclerostin
#8
Haoruo Jia, Xiaoyuan Ma, Yulong Wei, Wei Tong, Robert J Tower, Abhishek Chandra, Luqiang Wang, Zeyang Sun, Zhaochun Yang, Farid Badar, Kairui Zhang, Wei-Ju Tseng, Ina Kramer, Michaela Kneissel, Yang Xia, X Sherry Liu, James H-C Wang, Lin Han, Motomi Enomoto-Iwamoto, Ling Qin
OBJECTIVE: To establish an unbiased 3D approach that quantifies subchondral bone plate (SBP) changes in mouse joints and to investigate the mechanism that mediates SBP sclerosis at a late stage of osteoarthritis (OA). DESIGN: A new microCT protocol was developed to characterize the entire SBP thickness in the distal femur of a mouse knee. Four mouse models with severe joint OA were generated: cartilage-specific Egfr knockout (CKO) mice at 2 months after surgical destabilization of the medial meniscus (DMM), aged Egfr CKO mice, wild-type (WT) mice at 10 months after DMM, and WT mice after DMM plus hemisectomy of the meniscus (DMMH) surgery...
October 12, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29021569/cushioning-the-cartilage-a-canonical-wnt-restricting-matter
#9
REVIEW
Silvia Monteagudo, Rik J Lories
Wnt signalling pathways have key roles in joint development, homeostasis and disease, particularly in osteoarthritis. New data is starting to reveal the importance of tightly regulating canonical Wnt signalling pathway activation to maintain homeostasis and health in articular cartilage. In addition to the presence of different Wnt antagonists that limit pathway activation in articular cartilage, the reciprocal crosstalk between the canonical and non-canonical cascades and competitive antagonism between different Wnt ligands seem to be critical in restraining excessive Wnt pathway activation...
October 12, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28991794/microbiological-and-physicochemical-evaluation-of-the-effluent-quality-in-a-membrane-bioreactor-system-to-meet-the-legislative-limits-for-wastewater-reuse
#10
Konstantinos Azis, Charalampos Vardalachakis, Spyridon Ntougias, Paraschos Melidis
The aim of this study was to assess the efficacy and effluent quality of a pilot-scale intermittently aerated and fed, externally submerged membrane bioreactor (MBRes) treating municipal wastewater. The effluent quality of the MBRes was evaluated regarding system ability to comply with the Greek legislative limits for restricted and unrestricted wastewater reuse. The average permeate flux was 13.9 L m(-2) h(-1), while the transmembrane pressure remained above the level of -110 mbar. Experimental data showed that biochemical oxygen demand, chemical oxygen demand, total nitrogen, PO4(3-)- P and total suspended solids removal efficiencies were 97...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28987866/kinematic-patterns-in-normal-and-degenerative-shoulders-part-ii-review-of-3-d-scapular-kinematic-patterns-in-patients-with-shoulder-pain-and-clinical-implications
#11
REVIEW
Marie-Martine Lefèvre-Colau, Christelle Nguyen, Clemence Palazzo, Frederic Srour, Guillaume Paris, Valerie Vuillemin, Serge Poiraudeau, Agnes Roby-Brami, Alexandra Roren
BACKGROUND: The global range of motion of the arm is the result of a coordinated motion of the shoulder complex including glenohumeral (GH), scapulothoracic, sternoclavicular and acromioclavicular joints. METHODS: This study is a non-systematic review of kinematic patterns in degenerated shoulders. It is a based on our own research on the kinematics of the shoulder complex and clinical experience. RESULTS: For patients with subacromial impingement syndrome without rotator-cuff tears, most kinematic studies showed a small superior humeral translation relative to the glenoid and decreased scapular lateral rotation and posterior tilt...
October 5, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28983455/long-term-cognitive-and-somatic-outcomes-of-enzyme-replacement-therapy-in-untransplanted-hurler-syndrome
#12
Julie B Eisengart, Jeanine Jarnes, Alia Ahmed, Igor Nestrasil, Richard Ziegler, Kathleen Delaney, Elsa Shapiro, Chester Whitley
Mucopolysaccharidosis type I (MPS I) was added to the Recommended Uniform Screening Panel for newborn screening in 2016, highlighting recognition that early treatment of MPS I is critical to stem progressive, irreversible disease manifestations. Enzyme replacement therapy (ERT) is an approved treatment for all MPS I phenotypes, but because the severe form (MPS IH, Hurler syndrome) involves rapid neurocognitive decline, the impermeable blood-brain-barrier is considered an obstacle for ERT. Instead, hematopoietic cell transplantation (HCT) has long been recommended, as it is believed to be the only therapy that arrests neurocognitive decline...
December 2017: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/28983412/clinical-significance-of-matrilin-3-gene-polymorphism-in-egyptian-patients-with-primary-knee-osteoarthritis
#13
Safia M Diab, Howyda M Kamal, Amira I Mansour, Rasha M Fawzy, Basma S Azab
OBJECTIVE: Osteoarthritis (OA) is a multifactorial, degenerative, and inflammatory disorder of joints causing damage of the articular cartilage, formation of osteophytes, and eburination of the subchondral bone. Matrilin-3 (MATN-3) is a non-collagenous oligomeric extracellular matrix protein (ECM), which is the smallest member of the matrilin family. This study was conducted to identify the potential association and clinical significance of MATN-3 rs8176070 (SNP6) polymorphism in a series of Egyptian patients with primary knee OA...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28982941/active-exercise-on-immobilization-induced-contractured-rat-knees-develops-arthrogenic-joint-contracture-with-pathological-changes
#14
Akinori Kaneguchi, Junya Ozawa, Kengo Minamimoto, Kaoru Yamaoka
This study investigated the effects of treadmill walking during remobilization on range of motion (ROM) and histopathology in rat knee joints, which were immobilized for three weeks in a flexed position. After fixator removal, rats were divided into a no-intervention (RM) group and a group forced to walk on a treadmill daily at 12 m/min for 60 min (WALK group). Passive knee extension ROMs were measured before (m-ROM) and after (a-ROM) knee flexor myotomy on the first and last day of a seven-day remobilization period, with m-ROM mainly reflecting myogenic factors and a-ROM reflecting arthrogenic factors...
October 5, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28982380/effectiveness-of-the-who-s-challenging-who-support-staff-training-intervention-to-improve-attitudes-and-empathy-towards-adults-with-intellectual-disability-and-challenging-behaviours-study-protocol-for-a-cluster-randomised-controlled-trial
#15
Elizabeth Randell, Richard P Hastings, Rachel McNamara, Roseanna Knight, David Gillespie, Zachary Taylor
BACKGROUND: Findings suggest approximately one in six people with intellectual disability engage in 'challenging behaviours', which include aggression towards others/property and self-injurious actions. In residential settings, actions of staff members can make challenging behaviours more likely to occur, or make these behaviours worse. In particular, negative attitudes from members of staff and lack of understanding about the reasons for challenging behaviour are contributory factors...
October 5, 2017: Trials
https://www.readbyqxmd.com/read/28975818/relative-motion-flexion-splinting-for-flexor-tendon-lacerations-proof-of-concept
#16
Bryan Chung, David T W Chiu, Vishal Thanik
BACKGROUND: The principle of relative motion has allowed patients to regain a higher degree of hand function, while protecting extensor tendon repairs. The purpose of this study was to determine whether the principle of relative motion could be a viable method to protect a flexor tendon repair. METHODS: Four fresh-frozen cadaver arms were each mounted on a testing apparatus (wrist in 30° of extension, metacarpophalangeal [MCP] joints blocked to 70°-80°). A minimum of 11 N was used to cyclically load the flexor digitorum profundus and extensor digitorum communis tendons to maximum allowable flexion and extension for 25 cycles...
October 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28970988/arthroscopic-focal-subspinal-decompression-and-management-of-pincer-type-femoroacetabular-impingement
#17
Renato Locks, Hajime Utsunomiya, Ioanna Bolia, Sandeep Mannava, Jorge Chahla, Marc J Philippon
Femoroacetabular impingement syndrome is a common hip pathology significantly affecting not only the intra- and extra-articular structures but also the biomechanical function of the joint. Cam and pincer bony lesions have been extensively studied. However, during recent years, other types of extra-articular impingement between the pelvic and femoral bone have been investigated. When a prominent or morphologically abnormal anterior-inferior iliac spine (AIIS) impinges repetitively on the femoral side during motion, the subspinal acetabular region becomes prominent and extends toward the intra-articular part of the joint...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28968170/broadening-eligibility-criteria-to-make-clinical-trials-more-representative-american-society-of-clinical-oncology-and-friends-of-cancer-research-joint-research-statement
#18
Edward S Kim, Suanna S Bruinooge, Samantha Roberts, Gwynn Ison, Nancy U Lin, Lia Gore, Thomas S Uldrick, Stuart M Lichtman, Nancy Roach, Julia A Beaver, Rajeshwari Sridhara, Paul J Hesketh, Andrea M Denicoff, Elizabeth Garrett-Mayer, Eric Rubin, Pratik Multani, Tatiana M Prowell, Caroline Schenkel, Marina Kozak, Jeff Allen, Ellen Sigal, Richard L Schilsky
Purpose The primary purposes of eligibility criteria are to protect the safety of trial participants and define the trial population. Excessive or overly restrictive eligibility criteria can slow trial accrual, jeopardize the generalizability of results, and limit understanding of the intervention's benefit-risk profile. Methods ASCO, Friends of Cancer Research, and the US Food and Drug Administration examined specific eligibility criteria (ie, brain metastases, minimum age, HIV infection, and organ dysfunction and prior and concurrent malignancies) to determine whether to modify definitions to extend trials to a broader population...
October 2, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28967368/is-cannabis-an-effective-treatment-for-joint-pain
#19
REVIEW
Richard J Miller, Rachel E Miller
Cannabis has been used to treat pain for thousands of years. However, since the early part of the 20th century, laws restricting cannabis use have limited its evaluation using modern scientific criteria. Over the last decade, the situation has started to change because of the increased availability of cannabis in the United States for either medical or recreational purposes, making it important to provide the public with accurate information as to the effectiveness of the drug for joint pain among other indications...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28967361/the-assessment-of-musculoskeletal-pain
#20
REVIEW
Gillian A Hawker
Musculoskeletal (MSK) pain has a major impact on people's quality of life. Chronic MSK pain causes sleep interruption, fatigue, depressed mood, activity limitations and participation restrictions. The impact of MSK pain is influenced by contextual factors, including comorbidity, arthritis coping efficacy and access to MSK care. Thus, MSK pain assessment warrants a bio-psychosocial perspective that includes pain, its downstream effects and contextual factors. Such an approach should incorporate elicitation of symptoms using patient-report questionnaires and physical examination to help localize the pain and assess for signs of inflammation, tenderness on palpation, pain on motion, joint instability and malalignment...
September 2017: Clinical and Experimental Rheumatology
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