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https://www.readbyqxmd.com/read/28100946/management-of-young-patients-with-temporomandibular-joint-ankylosis-a-surgical-and-anesthetic-challenge
#1
REVIEW
Devalina Goswami, Sweta Singh, Ongkila Bhutia, Dalim Baidya, Chhavi Sawhney
Temporomandibular joint ankylosis is a unique disease where fracture of the mandibular condyle or any other cause leading to ankylosis of the joint can lead to multiple problems if not detected and treated early. If affected in early years of life, it may cause facial dysmorphism, restricted mouth opening, and difficulty in eating, speech, and sleep. Early surgery and physiotherapy can restore the joint function to a great extent. Anesthetizing a pediatric patient with this disorder is a definite challenge which needs expertise in difficult airway management...
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28099218/perceptions-in-rheumatoid-arthritis-comparative-study-between-patients-and-their-close-families
#2
Lamyae Bouhouche, Samira Rostom, Zineb Malouli Idrissi, Rachid Bahiri, Najia Hajjaj-Hassouni
OBJECTIVE: To compare perceptions of patients with rheumatoid arthritis (RA) to those of their families regarding pain and subjective experience of the disease. METHODS: It was a monocentric study, including 120 RA patients (according to the American College of Rheumatology criteria). The questionnaires were developed during meetings of RA patients, rheumatologists, and methodologists while referring to the literature. The patient questionnaire comprised 22 items organized in 4 sections: pain, perceived experience of the disease, activity restrictions, and help received...
January 18, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28095095/joint-association-of-complement-component-3-and-cc-cytokine-ligand2-ccl2-or-complement-component-3-and-cfh-polymorphisms-in-age-related-macular-degeneration
#3
Mortaza Bonyadi, Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Tahereh Mohammadian, Nikou Fotouhi, Alireza Javadzadeh, Masoud Soheilian
BACKGROUND: To determine the joint effect of complement component 3(C3 R102G) with CC-cytokine ligand2 (CCL2-2518) or complement factor H (CFH) Y402H polymorphisms on advanced age-related macular degeneration (AMD). METHODS: In this case-control study, 233 patients with advanced AMD and 159 unrelated healthy controls enrolled for evaluation. Selected polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: A combination of AA CCL2 (rs1024611) and GG C3 (R102G) genotypes resulted in a super-additivity of the risks: OR = 10...
January 17, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28088244/study-of-the-variability-of-scapular-inclination-and-the-glenoid-version-considerations-for-preoperative-planning-clinical-radiological-study
#4
Petr Fulin, Martin Kysilko, David Pokorny, Radek Padr, Nikola Kasprikova, Ivan Landor, Antonin Sosna
BACKGROUND: Preoperative planning with the aid of imaging methods is a principal factor in successful surgery on the shoulder. This work aims to evaluate the variability of glenoid version, spiralling twist and scapular inclination in relation to the frontal axis. Studies focusing on measuring the variability of scapular inclination in the standardised rest position are lacking in the literature. METHODS: We evaluated 104 CT scans of the shoulder. We measured the glenoid version with respect to the scapular axis at three levels...
January 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28088047/sliding-doors-did-drama-based-inter-professional-education-improve-the-tensions-round-person-centred-nursing-and-social-care-delivery-for-people-with-dementia-a-mixed-method-exploratory-study
#5
Lindsay Dingwall, Jane Fenton, Timothy B Kelly, John Lee
This educational intervention takes place when the population of older people with dementia is increasing. Health and Social care professionals must work jointly in increasingly complex contexts. Negative attitudes towards older people are cited as a contributor to poor care delivery, including the use of dismissive and/or patronising language, failing to meet fundamental needs and afford choice. 'Sliding Doors to Personal Futures' is a joint, drama-based, educational initiative between NHS Education Scotland and the Scottish Social Services Council, delivered using interprofessional education (IPE) towards encouraging person-centred health and social care...
December 21, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/28079892/hif-2%C3%AE-and-oct4-have-synergistic-effects-on-survival-and-myocardial-repair-of-very-small-embryonic-like-mesenchymal-stem-cells-in-infarcted-hearts
#6
Shaoheng Zhang, Lan Zhao, Jiahong Wang, Nannan Chen, Jian Yan, Xin Pan
Poor cell survival and limited functional benefits have restricted mesenchymal stem cell (MSC) efficacy for treating myocardial infarction (MI), suggesting that a better understanding of stem cell biology is needed. The transcription factor HIF-2α is an essential regulator of the transcriptional response to hypoxia, which can interact with embryonic stem cells (ESCs) transcription factor Oct4 and modulate its signaling. Here, we obtained very small embryonic-like mesenchymal stem cells (vselMSCs) from MI patients, which possessed the very small embryonic-like stem cells' (VSELs) morphology as well as ESCs' pluripotency...
January 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28074258/the-treatment-options-for-posterior-malleolar-fractures-in-tibial-spiral-fractures
#7
Jialiang Guo, Lei Liu, Zongyou Yang, Zhiyong Hou, Wei Chen, Yingze Zhang
PURPOSE: The posterior malleolar fracture (PMF) in tibial spiral fractures are a common type of complication that occurs in tibial fractures. However, the indication of fixation for posterior fractures is still under debate and varies between different surgeons'. It is not unusual to find the smaller PMF (<25%), which could be treated conservatively within guidelines, treated with internal fixation in clinic. The aim of this study is to evaluate the clinical outcomes of tibial spiral fractures with PMF and provide proper guidance for the treatment of this special fracture...
January 10, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28053536/identification-of-a-new-mutation-in-an-iranian-family-with-hereditary-multiple-osteochondromas
#8
Susan Akbaroghli, Maryam Balali, Behnam Kamalidehghan, Siamak Saber, Omid Aryani, Goh Yong Meng, Massoud Houshmand
BACKGROUND: Hereditary multiple osteochondromas (HMO), previously named hereditary multiple exostoses (HME), is an autosomal dominant skeletal disorder characterized by the growth of multiple osteochondromas and is associated with bony deformity, skeletal growth reduction, nerve compression, restriction of joint motion, and premature osteoarthrosis. HMO is genetically heterogeneous, localized on at least three chromosomal loci including 8q24.1 (EXT1), 11p11-p13 (EXT2), and 19p (EXT3)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28053258/ankle-joint-pressure-changes-in-high-tibial-and-distal-femoral-osteotomies-a-cadaver-study
#9
F Krause, A Barandun, G Klammer, I Zderic, B Gueorguiev, T Schmid
AIMS: To assess the effect of high tibial and distal femoral osteotomies (HTO and DFO) on the pressure characteristics of the ankle joint. MATERIALS AND METHODS: Varus and valgus malalignment of the knee was simulated in human cadaver full-length legs. Testing included four measurements: baseline malalignment, 5° and 10° re-aligning osteotomy, and control baseline malalignment. For HTO, testing was rerun with the subtalar joint fixed. In order to represent half body weight, a 300 N force was applied onto the femoral head...
January 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28051862/combined-utilization-of-1-h-nmr-ir-and-theoretical-calculations-to-elucidate-the-conformational-preferences-of-some-l-histidine-derivatives
#10
Carolyne B Braga, Roberto Rittner
The conformational preferences of amino acids and their derivatives have been the subject of many investigations, because protein folding pathways that determine three-dimensional geometries are primarily restricted by the conformational space of each amino acid residue. Here we systematically describe the conformational behavior of l-histidine methyl ester (His-OMe) and its N-acetylated derivative (Ac-His-OMe) in the isolated phase and in solution. To this end, we employed spectroscopic techniques ((1)H NMR and IR), supported by quantum chemical calculations...
January 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28048953/a-multifunction-muscle-in-squid
#11
Joseph T Thompson, Scott M Lavalva, Matthew M Loiacono
Some striated muscles are multifunctional; they serve several different roles during locomotion and movement, including acting as motors, brakes, struts, or springs. The few multifunctional muscles that have been reported occur in the cross-striated muscles of animals with complex, jointed, skeletal support systems. In the comparatively simple muscular system of a cephalopod mollusc, we identified an obliquely striated muscle, the nuchal retractor muscle, which appears to be multifunctional. The nuchal retractor is composed of two different fiber types, mitochondria-rich (MR) and mitochondria-poor (MP) fibers; shortening of these fibers retracts the head toward the mantle...
December 2016: Biological Bulletin
https://www.readbyqxmd.com/read/28039974/method-for-reconstructing-nonlinear-modes-with-adaptive-structure-from-multidimensional-data
#12
Andrey Gavrilov, Dmitry Mukhin, Evgeny Loskutov, Evgeny Volodin, Alexander Feigin, Juergen Kurths
We present a detailed description of a new approach for the extraction of principal nonlinear dynamical modes (NDMs) from high-dimensional data. The method of NDMs allows the joint reconstruction of hidden scalar time series underlying the observational variability together with a transformation mapping these time series to the physical space. Special Bayesian prior restrictions on the solution properties provide an efficient recognition of spatial patterns evolving in time and characterized by clearly separated time scales...
December 2016: Chaos
https://www.readbyqxmd.com/read/28038347/identifying-ecological-barriers-in-marine-environment-the-case-study-of-dasyatis-marianae
#13
Tiego L A Costa, M Grazia Pennino, Liana F Mendes
Ecological barriers are important determinants of the evolution and distributions marine organisms, and a challenge for evolutionary ecologists seeking to understand population structure in the sea. Dasyatis marianae is an endemic Brazilian species that indicates certain restrictions on its distribution probably due to marine barriers. In this study, Bayesian hierarchical spatial models, jointly with environmental and occurrence species data, are used to identify, which elements could generate these barriers on Dasyatis marianae distribution...
December 19, 2016: Marine Environmental Research
https://www.readbyqxmd.com/read/28027660/cross-sectional-study-to-assess-the-functional-outcome-of-neglected-bimalleolar-fracture
#14
Rajeev Shukla, Ravi Kant Jain, Shravan Patidar, Nikhil Jain, Pranav Mahajan
INTRODUCTION: Ankle fracture is the most common intra-articular fracture of a weight-bearing joint and accounts for 9% of all fractures. Ankle fractures are classified into 3 subgroups: unimalleolar, bimalleolar, and trimalleolar fractures. Accurate reduction and stable internal fixation is necessary in bimalleolar fractures; otherwise, it may lead to posttraumatic painful restriction of movements or osteoarthritis. The purpose of this study is to assess the functional outcome and results of treatment of neglected bimalleolar fracture...
December 1, 2016: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28027039/effectiveness-of-occupational-therapy-interventions-for-musculoskeletal-shoulder-conditions-a-systematic-review
#15
Tambra L Marik, Shawn C Roll
People with musculoskeletal disorders of the shoulder commonly experience pain, decreased strength, and restricted range of motion (ROM) that limit participation in meaningful occupational activities. The purpose of this systematic review was to evaluate the current evidence for interventions within the occupational therapy scope of practice that address pain reduction and increase participation in functional activities. Seventy-six studies were reviewed for this study-67 of Level I evidence, 7 of Level II evidence, and 2 of Level III evidence...
January 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/28025183/inequality-in-treatment-benefits-can-we-determine-if-a-new-treatment-benefits-the-many-or-the-few
#16
Emily J Huang, Ethan X Fang, Daniel F Hanley, Michael Rosenblum
SUMMARYIn many randomized controlled trials, the primary analysis focuses on the average treatment effect and does not address whether treatment benefits are widespread or limited to a select few. This problem affects many disease areas, since it stems from how randomized trials, often the gold standard for evaluating treatments, are designed and analyzed. Our goal is to learn about the fraction who benefit from a new treatment using randomized trial data. We consider the case where the outcome is ordinal, with binary outcomes as a special case...
December 26, 2016: Biostatistics
https://www.readbyqxmd.com/read/28018079/a-case-of-bilateral-aberrant-pectoralis-minor-insertion-with-absent-coracohumeral-ligament-clinical-relevance-and-controversies
#17
Vivek Pandey, Sandesh Madi, Satish Maddukuri, N Deepika, Nazar Hafiz, Kiran Acharya
Aberrant insertions of the pectoralis minor tendon are quite rare. Most cases are incidental findings during cadaver dissections, on an MRI or during surgical procedures of the shoulder joint. Rarely the aberrant insertion points can be a source of pain or restriction of the shoulder joint. From the literature review, we found that there has been no mention regarding the frequency of occurrence of this variation with respect to unilateral or bilateral occurence, and only three cases have been reported, in which aberrant bilateral insertions have been documented of which two were noted during cadaveric dissection and one radiologically...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28004964/patient-safety-under-deep-sedation-for-digestive-endoscopic-procedures
#18
Julián Álvarez, Rafael Cabadas, Manuel de la Matta
Deep sedation with Propofol has become popular in recent years. The safety of this technique when administered by non-anaesthesiologists has created much controversy which at times is masked in a contentious debate on the economic sustainability of the health system. In 2011, the Spanish Society of Anaesthesiology, Resuscitation and Pain Therapy, along with 20 other organisations from European countries, revoked the recommendations of the European Society of Gastrointestinal Endoscopy on the administration of Propofol by non-anaesthesiologists, citing that it is "extremely dangerous for the safety and quality of endoscopic procedures"...
December 22, 2016: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28003769/chronic-radiation-induced-dermatitis-challenges-and-solutions
#19
REVIEW
Mateusz Spałek
Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients' quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chronic radiation dermatitis is mostly caused by the imbalance of proinflammatory and profibrotic cytokines. Clinical manifestation includes changes in skin appearance, wounds, ulcerations, necrosis, fibrosis, and secondary cancers...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28002590/association-between-174g-c-and-572g-c-interleukin-6-gene-polymorphisms-and-severe-radiographic-damage-to-the-hands-of-mexican-patients-with-rheumatoid-arthritis-a-preliminary-report
#20
S A Zavaleta-Muñiz, L Gonzalez-Lopez, J D Murillo-Vazquez, A M Saldaña-Cruz, M L Vazquez-Villegas, B T Martín-Márquez, J C Vasquez-Jimenez, F Sandoval-Garcia, A J Ruiz-Padilla, N S Fajardo-Robledo, J M Ponce-Guarneros, A D Rocha-Muñoz, M F Alcaraz-Lopez, D Cardona-Müller, S E Totsuka-Sutto, E D Rubio-Arellano, J I Gamez-Nava
Several interleukin 6 gene (IL6) polymorphisms are implicated in susceptibility to rheumatoid arthritis (RA). It has not yet been established with certainty if these polymorphisms are associated with the severe radiographic damage observed in some RA patients, particularly those with the development of joint bone ankylosis (JBA). The objective of the present study was to evaluate the association between severe radiographic damage in hands and the -174G/C and -572G/C IL6 polymorphisms in Mexican Mestizo people with RA...
December 19, 2016: Genetics and Molecular Research: GMR
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