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Estrogen Reduction

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https://www.readbyqxmd.com/read/29229551/modulation-of-reactive-oxygen-species-via-erk-and-stat3-dependent-signalling-are-involved-in-the-response-of-mesothelioma-cells-to-exemestane
#1
Barbara Nuvoli, Emanuela Camera, Arianna Mastrofrancesco, Stefania Briganti, Rossella Galati
Pleural mesothelioma is a deadly form of cancer. The prognosis is extremely poor due to the limited treatment modalities. Uptake of asbestos fibres, the leading cause of mesothelioma, lead to the accumulation of reactive-oxygen-species (ROS). Interestingly, increasing ROS production by using ROS-generating drugs may offer a strategy to selectively trigger cell death. Exemestane, an aromatase inhibitor, has previously shown anti-tumor properties in mesothelioma preclinical models suggesting a role of G protein-coupled receptor 30 (GPR30) in the drug response...
December 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29228315/comparison-of-neoadjuvant-nab-paclitaxel-carboplatin-vs-nab-paclitaxel-gemcitabine-in-triple-negative-breast-cancer-randomized-wsg-adapt-tn-trial-results
#2
Oleg Gluz, Ulrike Nitz, Cornelia Liedtke, Matthias Christgen, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Nikola Bangemann, Christoph Lindner, Sherko Kuemmel, Michael Clemens, Jochem Potenberg, Peter Staib, Andreas Kohls, Raquel von Schumann, Ronald Kates, Ronald Kates, Johannes Schumacher, Rachel Wuerstlein, Hans Heinrich Kreipe, Nadia Harbeck
Background: Pathological complete response (pCR) is associated with improved prognosis in triple-negative breast cancer (TNBC). The optimal chemotherapy regimen is unclear. Weekly nab-paclitaxel vs conventional paclitaxel or addition of carboplatin to anthracycline-taxane results in higher pCR rates with uncertain survival impact. We evaluated carboplatin vs gemcitabine with a nab-paclitaxel backbone as a short 12-week A-free regimen with a focus on early response. Methods: Patients with TNBC (estrogen receptor/progesterone receptor < 1%, human epidermal growth factor receptor 2-negative, cT1c-cT4c, cN0/+) were randomly assigned to A: nab-paclitaxel 125 mg/m2/gemcitabine 1000 mg/m2 d1,8 three times weekly (q3w); vs B: nab-paclitaxel 125 mg/m2/carboplatin AUC2 day 1,8 q3w...
December 8, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29228121/low-dose-bisphenol-a-activates-the-erk-signaling-pathway-and-attenuates-steroidogenic-gene-expression-in-human-placental-cells
#3
Po-Wei Chu, Zhi-Jie Yang, Huei-Shing Huang, Ai-An Chang, Yu-Chen Cheng, Gwo-Jang Wu, Hsin-Chieh Lan
Bisphenol A (BPA) is an industrial material used for many plastic products and is considered an endocrine disruptor. BPA can be released into the environment and can spread through the food chain. It is well known that BPA exposure leads to lesions, especially in the reproductive system. According to previous studies, BPA reduces newborn numbers in pregnant mice and affects placentation. The placenta is a special endocrine organ during pregnancy. It secretes important hormones, such as progesterone and estrogen, to maintain gestation...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29226072/a-thermal-gradient-modulates-the-oxidative-metabolism-and-growth-of-human-keratinocytes
#4
Marta Viano, Daniela Alotto, Alessia Aillon, Carlotta Castagnoli, Francesca Silvagno
During their spatial and differentiative progression, keratinocytes face a thermal gradient, from 37 °C in the proliferating basal layer to 32 °C found in skin surface. In our study, we hypothesized that this difference in temperature must be balanced by increasing the heat produced during respiratory activity. We demonstrated that at 33 °C human primary keratinocytes and HaCaT cells raised mitochondrial energy metabolism, but not glycolytic activity. At 33 °C, the increased mitochondrial ATP synthesis was associated with a strong induction of the modulator of the respiratory chain estrogen receptor β, whereas uncoupling protein 1 expression was not changed...
December 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29220789/new-estrogen-receptor-antagonists-3-20-dihydroxy-19-norpregna-1-3-5-10-trienes-synthesis-molecular-modeling-and-biological-evaluation
#5
Yury V Kuznetsov, Inna S Levina, Alexander M Scherbakov, Olga E Andreeva, Irina V Fedyushkina, Andrey S Dmitrenok, Alexander S Shashkov, Igor V Zavarzin
New estrogen receptor α (ERα) antagonists - 3,20-dihydroxy-19-norpregna-1,3,5(10)-trienes containing an additional carbocyclic ring D' at the 16α,17α positions - were synthesized. The effects of the new compounds on the MCF-7 breast cancer cells and ERα activation were investigated. All the steroids studied were synthesized starting from estrone methyl ether. The scaffold of compounds containing the six-membered ring D' was constructed via the Diels-Alder reaction of butadiene with 3-methoxy-19-norpregna-1,3,5(10),16-tetraen-20-one 5...
November 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29202668/quality-of-life-and-care-needs-in-women-with-estrogen-positive-metastatic-breast-cancer-a-qualitative-study
#6
Gitte Lee Mortensen, Ivan Bredbjerg Madsen, Randi Krogsgaard, Bent Ejlertsen
BACKGROUND: In recent years, the prognosis of metastatic breast cancer (MBC) has improved with more effective therapies applicable to a wider range of patients. To many patients, a MBC diagnosis thus initiates a prolonged course of illness and treatment. This qualitative study aimed to explore the long-term health-related quality of life (HRQoL) and support needs in MBC patients of all ages in the Danish context. MATERIAL AND METHODS: Eighteen MBC patients participated in five qualitative focus group interviews that were analyzed using content analysis and a constructivist approach...
December 5, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29196963/serum-lipid-and-bone-metabolism-effects-of-toremifene-vs-letrozole-as-adjuvant-therapy-for-postmenopausal-early-breast-cancer-patients-results-of-a-multicenter-open-randomized-study
#7
Tadahiko Shien, Hiroyoshi Doihara, Nobuaki Sato, Keisei Anan, Kansei Komaki, Keisuke Miyauchi, Yasuhiro Yanagita, Tomomi Fujisawa, Shoshu Mitsuyama, Chizuko Kanbayashi, Mikihiro Kusama, Morihiko Kimura, Hiromitsu Jinno, Muneaki Sano, Tadashi Ikeda
A prospective randomized phase II trial was conducted to evaluate the time course effects of toremifene (TOR) and letrozole (LET), as adjuvant hormone therapy, on serum lipid profiles and bone metabolism in estrogen receptor (ER)-positive, postmenopausal breast cancer patients.Fifty-four postmenopausal breast cancer patients [ER positive, HER2 negative, T1-2, node metastases (n = 0-3), M0] who had undergone curative resection were enrolled. They were randomized to receive either TOR 40 mg/day or LET 2...
December 1, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29192236/estrogen-attenuates-agtr1-expression-to-reduce-pancreatic-%C3%AE-cell-death-from-high-glucose
#8
Suwattanee Kooptiwut, Keerati Wanchai, Namoiy Semprasert, Chatchawan Srisawat, Pa-Thai Yenchitsomanus
Chronic exposure of pancreatic β-cells to high glucose levels results in β-cell dysfunction and death. These effects can be protected by estrogen. The local pancreatic renin-angiotensin system (RAS) has been shown as a novel pathological pathway of high-glucose-induced cell death. The effect of estrogen on pancreatic RAS is still unknown. This study examines whether estrogen protects against pancreatic β-cell death caused by glucotoxicity via a decrease in the pancreatic β-cell RAS pathway. When INS-1 cells were cultured in a high glucose medium, cell death was significantly higher than when the cells were cultured in a basal glucose medium; similarly, there were also higher levels of AGTR1 and p47 ph ° x mRNA, and protein expression...
November 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29189985/evaluation-of-the-effect-of-the-new-methoxy-stilbenes-on-expression-of-receptors-and-enzymes-involved-in-estrogen-synthesis-in-cancer-breast-cells
#9
Barbara Licznerska, Hanna Szaefer, Marcin Wierzchowski, Renata Mikstacka, Katarzyna Papierska, Wanda Baer-Dubowska
Our previous study showed that the new synthetic methoxy-stilbenes, 3,4,2'-trimethoxy-trans-stilbene (3MS), 3,4,2',4'-tetramethoxy-trans-stilbene (4MS), and 3,4,2',4',6'-pentamethoxy-trans-stilbene (5MS), modulate the constitutive expression of enzymes and receptors involved in estrogen metabolism in breast immortalized epithelial MCF10 cells. In this study, we evaluated the effect of 3MS, 4MS, and 5MS in comparison to resveratrol activity in MCF7 estrogen-dependent and MDA-MB-231 estrogen-independent breast cancer cell lines...
November 30, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29189600/pharmacoeconomic-and-associated-cost-savings-among-women-who-were-prescribed-systemic-conjugated-estrogens-therapy-compared-with-those-without-menopausal-therapy
#10
Wing Yu Tang, Dale Grothe, Allison Keshishian, Diana Morgenstern, Seema Haider
OBJECTIVE: To explore changes in healthcare costs among postmenopausal women in a commercial population who were prescribed conjugated estrogens for menopausal symptoms. METHODS: Using the MarketScan dataset from April 1, 2008 through September 30, 2012, postmenopausal women aged ≥45 years, who were prescribed conjugated estrogen tablets (Premarin), were identified. A comparative cohort of postmenopausal women with vasomotor symptoms without any menopause therapy was also identified...
November 20, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29187227/obesity-reversibly-depletes-the-basal-cell-population-and-enhances-mammary-epithelial-cell-estrogen-receptor-alpha-expression-and-progenitor-activity
#11
Tamara Chamberlin, Joseph V D'Amato, Lisa M Arendt
BACKGROUND: Obesity is correlated with an increased risk for developing postmenopausal breast cancer. Since obesity rates continue to rise worldwide, it is important to understand how the obese microenvironment influences normal mammary tissue to increase breast cancer risk. We hypothesized that obesity increases the proportion of luminal progenitor cells, which are thought to be the cells of origin for the most common types of breast cancer, potentially leading to an increased risk for breast cancer...
November 29, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29181390/gender-differences-in-the-progression-of-experimental-chronic-kidney-disease-induced-by-chronic-nitric-oxide-inhibition
#12
Camilla Fanelli, Humberto Dellê, Rita Cassia Cavaglieri, Wagner Vasques Dominguez, Irene L Noronha
Chronic kidney disease (CKD) is considered a public health problem, assuming epidemic proportions worldwide. In this context, the preponderance of CKD prevalence in male over age-matched female patients is of note. In the present study, we investigated the impact of the gender on the development of experimental CKD induced by chronic nitric oxide (NO) inhibition in Wistar male and female rats through the administration of L-NAME. CKD model induced by L-NAME is characterized by systemic vasoconstriction, resulting in severe hypertension, albuminuria, renal ischemia, glomerulosclerosis, interstitial expansion, and macrophage infiltration...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29174957/alternatives-to-testosterone-therapy-a-review
#13
REVIEW
Eric M Lo, Katherine M Rodriguez, Alexander W Pastuszak, Mohit Khera
INTRODUCTION: Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives. AIMS: To review the role and limitations of non-testosterone treatments for hypogonadism...
November 23, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29171470/-shereshevsky-turner-syndrome-estrogen-replacement-therapy-and-cardiovascular-risk-factors
#14
O A Yevstigneeva, E N Andreeva, O R Grigoryan, N N Volevodz, G A Melnichenko, I I Dedov
AIM: To investigate the impact of menopausal hormone therapy (MHT) on the expression of risk factors for cardiovascular events (CVEs) in patients with Shereshevsky-Turner syndrome (STS); to elaborate an algorithm for patient management using MHT. SUBJECTS AND METHODS: From 2010 to 2012, a total of 41 patients aged 14 to 35 years with STS were examined in the framework of a prospective observational study. 100 STS case histories in 2000 to 2009 were retrospectively analyzed...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/29163055/study-of-sex-differences-in-duloxetine-efficacy-for-depression-in-transgenic-mouse-models
#15
Yong Xu, Lei Ma, Wei Jiang, Yuhong Li, Gang Wang, Rena Li
Clinical evidences show sex differences in risk of developing depressive disorders as well as effect of antidepressants in depression treatment. However, whether such a sex-dependent risk of depression and efficacy of antidepressants is dependent on endogenous estrogen level remain elusive. The aim of this study is to explore the molecular mechanisms of sex differences in antidepressant duloxetine. In the present study, we used genetic knockout or overexpression estrogen-synthesizing enzyme aromatase (Ar) gene as models for endogenous estrogen deficiency and elevation endogenous estrogen, respectively, to examine the anti-depressive efficacy of duloxetine in males and females by force swimming test (FST)...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29162134/serum-thymidine-kinase-1-activity-as-a-pharmacodynamic-marker-of-cyclin-dependent-kinase-4-6-inhibition-in-patients-with-early-stage-breast-cancer-receiving-neoadjuvant-palbociclib
#16
Nusayba Bagegni, Shana Thomas, Ning Liu, Jingqin Luo, Jeremy Hoog, Donald W Northfelt, Matthew P Goetz, Andres Forero, Mattias Bergqvist, Jakob Karen, Magnus Neumüller, Edward M Suh, Zhanfang Guo, Kiran Vij, Souzan Sanati, Matthew Ellis, Cynthia X Ma
BACKGROUND: Thymidine kinase 1 (TK1) is a cell cycle-regulated enzyme with peak expression in the S phase during DNA synthesis, and it is an attractive biomarker of cell proliferation. Serum TK1 activity has demonstrated prognostic value in patients with early-stage breast cancer. Because cyclin-dependent kinase 4/6 (CDK4/6) inhibitors prevent G1/S transition, we hypothesized that serum TK1 could be a biomarker for CDK4/6 inhibitors. We examined the drug-induced change in serum TK1 as well as its correlation with change in tumor Ki-67 levels in patients enrolled in the NeoPalAna trial (ClinicalTrials...
November 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29160371/effect-of-ovariectomy-in-bone-structure-of-mandibular-condyle
#17
Cristina Constâncio, Bruna Trazzi Pagani, Regina Magrini Guedes de Azevedo, Dalva Pazzini Grion, Leonardo Marques, Angela Kinoshita
PURPOSE: To evaluate the bone structure of the mandibular condyle through an animal model, after ovariectomy. METHODS: Thirty-six female Wistar rats were divided into 2 groups. The OVX group was submitted to bilateral ovariectomy, the SHAM group underwent the same surgical treatment, but without removal of the ovaries. After 90, 105 and 135 days after surgery, six animals from each group were submitted to euthanasia and the part containing the condyle was removed...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29151229/effects-of-female-sex-steroids-administration-on-pathophysiologic-mechanisms-in-traumatic-brain-injury
#18
REVIEW
Mohammad Khaksari, Zahra Soltani, Nader Shahrokhi
Secondary brain damage following initial brain damage in traumatic brain injury (TBI) is a major cause of adverse outcomes. There are many gaps in TBI research and a lack of therapy to limit debilitating outcomes in TBI or enhance the neurogenesis, despite pre-clinical and clinical research performed in TBI. Females show harmful outcomes against brain damage including TBI less than males, independent of different TBI occurrence. A significant reduction in secondary brain damage and improvement in neurologic outcome post-TBI has been reported following the use of progesterone and estrogen in many experimental studies...
November 19, 2017: Translational Stroke Research
https://www.readbyqxmd.com/read/29140706/a-galactosylated-pro-drug-of-ursodeoxycholic-acid-design-synthesis-characterization-and-pharmacological-effects-in-a-rat-model-of-estrogen-induced-cholestasis
#19
Francesca Di Guida, Claudio Pirozzi, Salvatore Magliocca, Anna Santoro, Adriano Lama, Roberto Russo, Maria Nieddu, Lucia Burrai, Gianpiero Boatto, Maria Pina Mollica, Federica Sodano, Loretta Lazzarato, Konstantin Chegaev, Rosaria Meli, Giuseppina Mattace Raso, Maria Grazia Rimoli
Ursodeoxycholic acid (UDCA) is considered the first-choice therapy for cholestatic disorders. To enhance solubility and exploit specific transporters in liver, we synthesized a new galactosyl pro-drug of UDCA (UDCAgal). Ethinylestradiol (EE)-induced cholestasis was used to study and compare the effects of UDCAgal with UDCA on bile flow, hepatic canalicular efflux transporter expression, and inflammation. UDCAgal resulted quite stable both at pH 7.4 and 1.2 and regenerated the parent drug after incubation in human plasma...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29140150/radiotherapy-for-cervical-cancer-impact-on-the-vaginal-epithelium-and-sexual-function
#20
Alexandra Hofsjö, Karin Bergmark, Bo Blomgren, Helen Jahren, Nina Bohm-Starke
BACKGROUND: Women who have been treated for cervical cancer have persistent changes in their sexual function, which result in considerable distress. The aim of this study was to investigate the morphology of the vaginal epithelium in cervical cancer survivors treated with radiotherapy and its correlation to serum levels of sex steroid hormones and sexual function. MATERIAL AND METHODS: We included 34 patients treated for cervical cancer with radiotherapy and 37 healthy age-matched control women scheduled for benign gynecological surgery...
November 15, 2017: Acta Oncologica
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