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Estrogen Reduction

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https://www.readbyqxmd.com/read/27906500/phylogenetic-studies-gene-cluster-analysis-and-enzymatic-reaction-support-anthrahydroquinone-reduction-as-the-physiological-function-of-fungal-17%C3%AE-hydroxysteroid-dehydrogenase
#1
Leon Fürtges, David Conradt, Michael A Schätzle, Shailesh Kumar Singh, Nada Kraševec, Tea Lanišnik Rižner, Michael Müller, Syed Masood Husain
17β-Hydroxysteroid dehydrogenase (17β-HSDcl) from the filamentous fungus Curvularia lunata (teleomorph Cochliobolus lunatus) catalyzes NADP(H)-dependent oxidoreductions of androgens and estrogens. Despite detailed biochemical and structural characterization of 17β-HSDcl, its physiological function remains unknown. On the basis of amino acid sequence alignment, phylogenetic studies, and the recent identification of the physiological substrates of the homologous MdpC from Aspergillus nidulans and AflM from Aspergillus parasiticus, we propose an anthrahydroquinone as the physiological substrate of 17β-HSDcl...
December 1, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27905115/treatment-for-hereditary-angioedema-with-normal-c1-inh-and-specific-mutations-in-the-f12-gene-hae-fxii
#2
K Bork, K Wulff, G Witzke, J Hardt
Hereditary angioedema with normal C1 esterase inhibitor and mutations in the F12 gene (HAE-FXII) is associated with skin swellings, abdominal pain attacks, and the risk of asphyxiation due to upper airway obstruction. It occurs nearly exclusively in women. We report our experience treating HAE-FXII with discontinuation of potential trigger factors and drug therapies. The study included 72 patients with HAE-FXII. Potential triggers included estrogen-containing oral contraceptives (eOC), hormonal replacement therapy, or angiotensin-converting enzyme inhibitors...
November 6, 2016: Allergy
https://www.readbyqxmd.com/read/27901017/daily-intake-and-hazard-index-of-parabens-based-upon-24%C3%A2-h-urine-samples-of-the-german-environmental-specimen-bank-from-1995-to-2012
#3
Rebecca K Moos, Petra Apel, Christa Schröter-Kermani, Marike Kolossa-Gehring, Thomas Brüning, Holger M Koch
In recent years, exposure to parabens has become more of a concern because of evidence of ubiquitous exposure in the general population, combined with evidence of their potency as endocrine disruptors. New human metabolism data from oral exposure experiments enable us to back calculate daily paraben intakes from urinary paraben levels. We report daily intakes (DIs) for six parabens based on 660 24 h urine samples from the German Environmental Specimen Bank collected between 1995 and 2012. Median DI values ranged between 1...
November 30, 2016: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/27893709/identification-of-myst3-as-a-novel-epigenetic-activator-of-er%C3%AE-frequently-amplified-in-breast-cancer
#4
L Yu, Y Liang, X Cao, X Wang, H Gao, S-Y Lin, R Schiff, X-S Wang, K Li
Estrogen receptor α (ERα) is a master driver of a vast majority of breast cancers. Breast cancer cells often develop resistance to endocrine therapy via restoration of the ERα activity through survival pathways. Thus identifying the epigenetic activator of ERα that can be targeted to block ERα gene expression is a critical topic of endocrine therapy. Here, integrative genomic analysis identified MYST3 as a potential oncogene target that is frequently amplified in breast cancer. MYST3 is involved in histone acetylation via its histone acetyltransferase domain (HAT) and, as a result, activates gene expression by altering chromatin structure...
November 28, 2016: Oncogene
https://www.readbyqxmd.com/read/27889857/accurate-control-of-17%C3%AE-estradiol-long-term-release-increases-reliability-and-reproducibility-of-preclinical-animal-studies
#5
Céline Gérard, Anne Gallez, Charline Dubois, Pierre Drion, Philippe Delahaut, Etienne Quertemont, Agnès Noël, Christel Pequeux
Estrogens are the subject of intensive researches aiming to elucidate their mechanism of action on the various tissues they target and especially on mammary gland and breast cancer. The use of ready-to-use slow releasing devices to administer steroids, especially estrogens, to small experimental animals remains the method of choice in terms of animal well-being and of safety for both the researcher and the animal. In this study, we evaluated and compared, in vitro and in vivo, the release kinetic of estradiol (E2) over sixty days from two different slow-releasing systems: the matrix pellet (MP) and the reservoir implant (RI)...
November 26, 2016: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/27885055/17b-estradiol-improves-hepatic-mitochondrial-biogenesis-and-function-through-pgc1b
#6
Bel M Galmés-Pascual, Antonia Nadal-Casellas, Marco Bauza-Thorbrügge, Miquel Sbert-Roig, Francisco José García-Palmer, Am Proenza, Magdalena Gianotti, Isabel Llado
Sexual dimorphism in mitochondrial biogenesis and function has been described in many rat tissues, with females showing larger and more functional mitochondria. The family of the peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1) plays a central role in the regulatory network governing mitochondrial biogenesis and function, but little is known about the different contribution of hepatic PGC1A and PGC1B in these processes. The aim of this study was to elucidate the role of 17b-estradiol (E2) in mitochondrial biogenesis and function in liver and assess the contribution of both hepatic PGC1A and PGC1B as mediators of these effects...
November 24, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27878271/estrogen-is-neuroprotective-against-hypoglycemic-injury-in-murine-n38-hypothalamic-cells
#7
Tandra R Chakraborty, Joshua Cohen, Darien Yohanan, Eilliut Alicea, Benjamin S Weeks, Sanjoy Chakraborty
Estrogen (E2) has been demonstrated to possess protective effects from hypoglycemic toxicity, particularly in the pancreas. In the central nervous system, several brain regions, such as the hypothalamus, are highly vulnerable to hypoglycemic injuries that may lead to seizures, coma, and mortality. The present study performed a novel in vitro assay of hypoglycemic injury to hypothalamic cells, and is the first study, to the best of our knowledge, to demonstrate that E2 protects hypothalamic cells from hypoglycemic toxicity...
November 18, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27875242/involvement-of-bdnf-trkb-and-erk-creb-axes-in-nitroglycerin-induced-rat-migraine-and-effects-of-estrogen-on-these-signals-in-the-migraine
#8
Jiu-Qing Guo, Hui-Hui Deng, Xiao Bo, Xiao-Su Yang
Migraine is a highly prevalent headache disorder especially in women. Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinases (TrkB), as well as extracellular signal-regulated kinase (ERK) and its downstream target c-AMP-responsive element binding protein (CREB) are strongly associated with the transmission of nociceptive information. However, the involvement of these substances in migraine has rarely been examined. In the present study, intraperitoneal injection of nitroglycerin (NTC) successfully induced rat migraine attack, as evidenced by the behavioral testing...
November 14, 2016: Biology Open
https://www.readbyqxmd.com/read/27870425/sex-and-the-development-of-alzheimer-s-disease
#9
REVIEW
Christian J Pike
Men and women exhibit differences in the development and progression of Alzheimer's disease (AD). The factors underlying the sex differences in AD are not well understood. This Review emphasizes the contributions of sex steroid hormones to the relationship between sex and AD. In women, events that decrease lifetime exposure to estrogens are generally associated with increased AD risk, whereas estrogen-based hormone therapy administered near the time of menopause may reduce AD risk. In men, estrogens do not exhibit age-related reduction and are not significantly associated with AD risk...
January 2, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27847844/potential-role-of-local-estrogen-in-enhancement-of-fracture-healing-preclinical-study-in-rabbits
#10
Mohammad Tahami, Behrooz Haddad, Armin Abtahian, Ali Hashemi, Amir Aminian, Sujith Konan
BACKGROUND: Effects of estrogen on bone metabolism and its protective role on prevention of osteoporosis are well documented. However, the efficacy of estrogen treatment on bone healing is not well investigated. The drug can be delivered both systemically or locally to the bone with differences in concentrations and side effects. The aim of this study was to investigate the effect of local and systemic administration of estrogen on the fracture healing process. METHODS: Standardized tibial fractures with 4 millimeter gaps were created in twenty four adult male Dutch rabbits...
October 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27836751/activation-of-gper-ameliorates-experimental-pulmonary-hypertension-in-male-rats
#11
Allan K Alencar, Guilherme C Montes, Tadeu Montagnoli, Ananssa M S Silva, Sabrina T Martinez, Aline G Fraga, Hao Wang, Leanne Groban, Roberto T Sudo, Gisele Zapata-Sudo
RATIONALE: Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling that leads to pulmonary congestion, uncompensated right-ventricle (RV) failure, and premature death. Preclinical studies have demonstrated that the G protein-coupled estrogen receptor (GPER) is cardioprotective in male rats and that its activation elicits vascular relaxation in rats of either sex. OBJECTIVES: To study the effects of GPER on the cardiopulmonary system by the administration of its selective agonist G1 in male rats with monocrotaline (MCT)-induced PH...
November 8, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27831918/17%C3%AE-estradiol-suppresses-visceral-adipogenesis-and-activates-brown-adipose-tissue-specific-gene-expression
#12
Saad Misfer Al-Qahtani, Galyna Bryzgalova, Ismael Valladolid-Acebes, Marion Korach-André, Karin Dahlman-Wright, Suad Efendić, Per-Olof Berggren, Neil Portwood
Both functional ovaries and estrogen replacement therapy (ERT) reduce the risk of type 2 diabetes (T2D). Understanding the mechanisms underlying the antidiabetic effects of 17β-estradiol (E2) may permit the development of a molecular targeting strategy for the treatment of metabolic disease. This study examines how the promotion of insulin sensitivity and weight loss by E2 treatment in high-fat-diet (HFD)-fed mice involve several anti-adipogenic processes in the visceral adipose tissue. Magnetic resonance imaging (MRI) revealed specific reductions in visceral adipose tissue volume in HFD+E2 mice, compared with HFD mice...
November 10, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27828688/the-polymorphism-of-estrogen-receptor-%C3%AE-is-important-for-metabolic-consequences-associated-with-menopause
#13
Jarosław Pinkas, Mariusz Gujski, Anna Wierzbińska-Stępniak, Alfred Owoc, Iwona Bojar
Menopause is associated with multiple health and metabolic consequences resulting from the decrease in estrogens level. Women at postmenopausal age are burdened with a higher risk of cardiovascular diseases, and the main cause of mortality in this group is ischemic heart disease. Estrogen deficiency is related, among other things, with frequent occurrence of dislipidemia, cessation of the beneficial effect of estrogens on the vascular wall, increase in body weight characterized by unfavourable redistribution of fatty tissue, with an increased amount of visceral fat and reduction of so-called non-fatty body mass...
November 9, 2016: Endokrynologia Polska
https://www.readbyqxmd.com/read/27823739/direct-and-indirect-effects-of-conjugated-estrogens-bazedoxifene-treatment-on-quality-of-life-in-postmenopausal-women
#14
Lucy Abraham, Andrew G Bushmakin, Erika Dragon, Barry S Komm, JoAnn V Pinkerton
OBJECTIVE: Determine the direct and indirect effects of conjugated estrogens/bazedoxifene (CE/BZA) treatment on menopause-specific quality of life in a post-hoc analysis of 2 phase 3 Selective estrogens, Menopause, And Response to Therapy (SMART-1, SMART-2) trials. STUDY DESIGN: Data from participants in SMART-1 and SMART-2 who received CE 0.45mg/BZA 20mg, CE 0.625mg/BZA 20mg, or placebo were analyzed, including week 12 data from 1274 healthy postmenopausal women in SMART-1 and pooled week 1-4 and 9-12 data from 332 women with moderate to severe vasomotor symptoms (≥7 HFs/d or ≥50/wk) in SMART-2...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27821721/coenzyme-q0-enhances-ultraviolet-b-induced-apoptosis-in-human-estrogen-receptor-positive-breast-mcf-7-cancer-cells
#15
Hui-Min Wang, Hsin-Ling Yang, Varadharajan Thiyagarajan, Tzu-Hsiang Huang, Pei-Jane Huang, Ssu-Ching Chen, Jer-Yuh Liu, Li-Sung Hsu, Hsueh-Wei Chang, You-Cheng Hseu
Coenzyme Q0 (CoQ0; 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a major active constituent of Antrodia camphorata, has been shown to inhibit human triple-negative breast cancer (MDA-MB-231) cells through induction of apoptosis and cell-cycle arrest. Ecological studies have suggested a possible association between ultraviolet B (UVB) radiation and reduction in the risk of breast cancer. However, the underlying mechanism of the combination of CoQ0 and UVB in human estrogen receptor-positive breast cancer (MCF-7) remains unclear...
November 7, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27814959/interaction-of-estrogen-receptor-%C3%AE-and-negative-life-events-in-susceptibility-to-major-depressive-disorder-in-a-chinese-han-female-population
#16
Jian Zhang, Lu Chen, Jingsong Ma, Zhengxue Qiao, Mingzhe Zhao, Dong Qi, Yan Zhao, Bo Ban, Xiongzhao Zhu, Jincai He, Yanjie Yang, Hui Pan
BACKGROUND: Both genetic and environmental factors as well as their interaction contribute to the etiology of major depressive disorder (MDD). Estrogen receptor β (ESR2) may play a vital role in the development of MDD in females. The aim of this study is to analyze ESR2 gene polymorphisms and the interaction of ESR2 gene variation and negative life events concerning the risk of developing MDD in females, especially during menopausal stage. METHODS: Genotyping was performed by Taqman allelic discrimination assay among 191 female MDD patients and 200 healthy females...
October 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27803593/association-between-basal-like-phenotype-and-brca1-2-germline-mutations-in-korean-breast-cancer-patients
#17
J Jung, E Kang, J M Gwak, A N Seo, S Y Park, A S Lee, H Baek, S Chae, E K Kim, S W Kim
INTRODUCTION: BRCA mutation testing allows index patients and their families to be provided with appropriate cancer risk-reduction strategies. Because of the low prevalence of BRCA mutations in unselected breast cancer patients and the high cost of genetic testing, it is important to identify the subset of women who are likely to carry BRCA mutations. In the present study, we examined the association between BRCA1/2 germline mutations and the immunohistochemical features of breast cancer...
October 2016: Current Oncology
https://www.readbyqxmd.com/read/27798863/substituted-tetrahydroisoquinolines-as-microtubule-destabilizing-agents-in-triple-negative-human-breast-cancer-cells
#18
Madhavi Gangapuram, Riccardo Jean, Elizabeth Mazzio, Ramesh Badisa, Suresh Eyunni, Carl B Goodman, Kinfe K Redda, Karam F Soliman
Triple-negative breast cancer (TNBC) occurs at greater frequency amongst African-Americans, being characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal receptor 2 (HER2). TNBC is often invasive and typically treated with cytostatic agents such as taxanes in combination with anthracyclines or platinum-based drugs. In this study, we synthesized a number of tetrahydroisoquinoline moieties by N-amination of substituted isoquinolines by O-mesytelene sulfonylhydroxylamine followed by ylide formation and reduction, which yielded the desired, substituted tetrahydroisoquinolines (THIQs) in moderate to good yield...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27797674/effect-of-soy-in-men-with-type-2-diabetes-mellitus-and-subclinical-hypogonadism-a-randomized-controlled-study
#19
Thozhukat Sathyapalan, Alan S Rigby, Shalender Bhasin, Natalie J Thatcher, Eric S Kilpatrick, Stephen L Atkin
CONTEXT: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to hypogonadism. OBJECTIVE: The primary outcome was change in total testosterone levels. The secondary outcomes were the changes in glycaemia and cardiovascular risk markers. DESIGN: Randomised double blind parallel study...
October 31, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27796923/recent-development-of-targeted-approaches-for-the-treatment-of-breast-cancer
#20
V L Maruthanila, R Elancheran, A B Kunnumakkara, S Kabilan, Jibon Kotoky
Breast cancer is the most prominent cause of cancer death in women worldwide. The highlights of this review are to provide an overview of the targeted therapeutic agents, challenges with metastatic breast cancer (MBCa), mechanisms of action through Hedgehog/Gli 1 signaling pathway and future prospective. Over a decade of success, several drugs have been approved and are in the advanced stages of clinical trials that target the receptors such as estrogen receptor, growth factor receptor, receptor activator of nuclear factor kappa-B, etc...
October 31, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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