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Estrogen Reduction

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https://www.readbyqxmd.com/read/29029113/estrogen-metabolism-in-abdominal-subcutaneous-and-visceral-adipose-tissue-in-postmenopausal-women
#1
Natalia Hetemäki, Hanna Savolainen-Peltonen, Matti J Tikkanen, Feng Wang, Hanna Paatela, Esa Hämäläinen, Ursula Turpeinen, Mikko Haanpää, Veera Vihma, Tomi S Mikkola
CONTEXT: In postmenopausal women, adipose tissue (AT) levels of estrogens exceed circulating concentrations. While increased visceral AT after menopause is related to metabolic diseases, little is known about differences in estrogen metabolism between different AT depots. OBJECTIVE: We compared concentrations of and metabolic pathways producing estrone and estradiol in abdominal subcutaneous and visceral AT in postmenopausal women. DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: AT and serum samples were obtained from 37 postmenopausal women undergoing surgery for non-malignant gynecological reasons...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29022497/estrogen-induced-disruption-of-intracellular-iron-metabolism-leads-to-oxidative-stress-membrane-damage-and-cell-cycle-arrest-in-mcf-7-cells
#2
Khuloud Bajbouj, Jasmin Shafarin, Maher Y Abdalla, Iman M Ahmad, Mawieh Hamad
It is well established that several forms of cancer associate with significant iron overload. Recent studies have suggested that estrogen (E2) disrupts intracellular iron homeostasis by reducing hepcidin synthesis and maintaining ferroportin integrity. Here, the ability of E2 to alter intracellular iron status and cell growth potential was investigated in MCF-7 cells treated with increasing concentrations of E2. Treated cells were assessed for intracellular iron status, the expression of key proteins involved in iron metabolism, oxidative stress, cell survival, growth, and apoptosis...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29022488/characterization-of-immortalized-human-mammary-epithelial-cell-line-hmec-2-6
#3
Pooja S Joshi, Vishnu Modur, JiMing Cheng, Kathy Robinson, Krishna Rao
Primary human mammary epithelial cells have a limited life span which makes it difficult to study them in vitro for most purposes. To overcome this problem, we have developed a cell line that was immortalized using defined genetic elements, and we have characterized this immortalized non-tumorigenic human mammary epithelial cell line to establish it as a potential model system. human mammary epithelial cells were obtained from a healthy individual undergoing reduction mammoplasty at SIU School of Medicine. The cells were transduced with CDK4R24C followed by transduction with human telomerase reverse transcriptase...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29018537/safety-pharmacokinetics-and-pharmacodynamics-of-amg-811-an-anti-interferon-%C3%AE-monoclonal-antibody-in-sle-subjects-without-or-with-lupus-nephritis
#4
Michael J Boedigheimer, David A Martin, Zahir Amoura, Jorge Sánchez-Guerrero, Juanita Romero-Diaz, Alan Kivitz, Cynthia Aranow, Tak Mao Chan, Yip Boon Chong, Kit Chiu, Christine Wang, Winnie Sohn, Gregory E Arnold, Michael A Damore, Andrew A Welcher, Barbara A Sullivan, Brian L Kotzin, James B Chung
OBJECTIVE: To evaluate safety, pharmacokinetics and pharmacodynamics of anti-interferon (IFN)-γ monoclonal antibody AMG 811 in subjects with SLE without or with lupus nephritis (LN). METHODS: In this phase Ib, randomised, multiple-dose escalation study (NCT00818948), subjects without LN were randomised to subcutaneous AMG 811 (6, 20 or 60 mg) or placebo and subjects with LN were randomised to subcutaneous AMG 811 (20, 60 or 120 mg) or placebo every four weeks for three total doses...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28993056/role-of-18-f-pet-ct-in-predicting-prognosis-of-patients-with-breast-cancer-after-neoadjuvant-chemotherapy
#5
Etsushi Akimoto, Takayuki Kadoya, Keiko Kajitani, Akiko Emi, Hideo Shigematsu, Masahiro Ohara, Norio Masumoto, Morihito Okada
BACKGROUND: Breast cancer can be assessed preoperatively and postoperatively using (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). We prospectively analyzed the maximum baseline standardized uptake value (SUVmax) derived from FDG PET/CT to predict the outcomes after neoadjuvant chemotherapy (NAC) for breast cancer. PATIENTS AND METHODS: We assessed 130 consecutive female patients with primary breast cancer (mean age, 53...
September 19, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28986195/surface-modified-mucoadhesive-microgels-as-a-controlled-release-system-for-miconazole-nitrate-to-improve-localized-treatment-of-vulvovaginal-candidiasis
#6
Franklin C Kenechukwu, Anthony A Attama, Emmanuel C Ibezim, Petra O Nnamani, Chukwuebuka E Umeyor, Emmanuel M Uronnachi, Thaddeus H Gugu, Mumuni A Momoh, Kenneth C Ofokansi, Paul A Akpa
The use of conventional vaginal formulations of miconazole nitrate (MN) in the treatment of deep-seated VVC (vulvovaginal candidiasis) is limited by poor penetration capacity and low solubility of MN, short residence time and irritation at the application site. Surface-modified mucoadhesive microgels were developed to minimize local irritation, enhance penetration capacity and solubility and prolong localized vaginal delivery of MN for effective treatment of deep-seated VVC. Solid lipid microparticles (SLMs) were prepared from matrices consisting of hydrogenated palm oil (Softisan® 154, SF) and super-refined sunseed oil (SO) with or without polyethylene glycol (PEG)-4000, characterized for physicochemical performance and used to prepare mucoadhesive microgels (MMs) encapsulating MN, employing Polycarbophil as bioadhesive polymer...
October 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28985044/biosynthesis-of-5-hydroxy-equol-and-5-hydroxy-dehydroequol-from-soy-isoflavone-genistein-using-microbial-whole-cell-bioconversion
#7
Pyung-Gang Lee, Joonwon Kim, Eun-Jung Kim, Sang-Hyuk Lee, Kwon-Young Choi, Romas J Kazlauskas, Byung-Gee Kim
Equols are isoflavandiols formed by reduction of soy isoflavones such as daidzein and genistein by gut microorganisms. These phytoestrogens are of interest for their various biological effects. We report biosynthesis from genistein to (-)-5-hydroxy-equol in recombinant E. coli expressing three reductases (daidzein reductase DZNR, dihidrodaidzein reductase DHDR, tetrahydrodaidzein reductase THDR) and a racemase (dihydrodaidzein racemase, DDRC) originating from the gut bacterium, Slackia isoflavoniconvertens...
October 6, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28982858/effects-of-s1p1-and-s1p3-in-er-and-er-breast-cancer-cells
#8
Ibrahim Ugur Calis, Didem Turgut Cosan, Fezan Mutlu
BACKGROUND/AIM: In this study, sphingosine-1-phosphate receptor-1 (S1P1) and S1P3 receptors were silenced to evaluate proliferation, adhesion, viability and lateral motility in estrogen receptor-negative MCF-7 and estrogen receptor-positive MDA-MB-231 breast cancer cells. MATERIALS AND METHODS: Groups of MCF-7 and MDA-MB-231 cells with: no small interfering RNA (siRNA); siRNA with no target; S1P1-silencing siRNA; S1P3-silencing siRNA; and siRNAs silencing both S1P1, and S1P3 were examined for this purpose at 24, 48 and 72 h after intervention...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28981954/differential-effect-of-the-ultra-low-dose-and-standard-estrogen-plus-dydrogesterone-therapy-on-thrombin-generation-and-fibrinolysis-in-postmenopausal-women
#9
Magdalena Piróg, Robert Jach, Olga Kacalska-Janssen
INTRODUCTION: The objective was to estimate the effects of different doses of oral hormone therapy (HT) on thrombin generation and fibrinolytic activity in postmenopausal women after 12-months treatment. MATERIAL AND METHODS: Thrombin generation, fibrinolysis activators and inhibitors were determined before, and after 12-months treatment. Participants (180) were assigned (1:1:1) as follows: 1) standard HT group, 17β-estradiol (1 mg/d) with dydrogesterone (5 mg/d); 2) ultra-low-dose HT group, 17β-estradiol (0...
October 5, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28980582/-focal-cerebral-ischemia-in-rats-with-estrogen-deficiency-and-endothelial-dysfunction
#10
A A Litvinov, E V Volotova, D V Kurkin, E O Logvinova, A P Darmanyan, I N Tyurenkov
AIM: To assess an effect of ovariectomy (OE) on the cerebral blood flow, endothelium-dependent vasodilation, neurological, cognitive and locomotor deficit as markers of brain damage after focal ischemia in rats. MATERIAL AND METHODS: The study was conducted in 48 female Wistar rats. Ovariectomy was performed with ovaries and uterine body extirpation, cerebral ischemia was performed by middle cerebral artery occlusion (MCAO) in rats. To assess brain damage, Combs and Garcia scores, 'open field' test (OFT), 'extrapolatory escape test' (EET), 'passive avoidance test' (PAT), 'beam-walking test' were used...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28979667/hormonal-therapy-in-traumatic-spinal-cord-injury
#11
REVIEW
Parker E Ludwig, Arun A Patil, Andrea J Chamczuk, Devendra K Agrawal
Traumatic spinal cord injuries are major health problems and the underlying pathophysiological events and treatment strategies are currently under investigation. In this article, we critically reviewed the literature investigating the effects of estrogen, progesterone, and human chorionic gonadotropin on spinal cord damage or preservation following traumatic spinal cord injury. The National Library of Medicine database was searched through December 2016 using PubMed for articles addressing the clinical relevance of the hormones to improve neural structural integrity following traumatic spinal cord injury...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28978566/nrg-oncology-national-surgical-adjuvant-breast-and-bowel-project-decision-making-project-1-results-decision-making-in-breast-cancer-risk-reduction
#12
Christine Holmberg, Hanna Bandos, Angela Fagerlin, Therese B Bevers, Tracy A Battaglia, D Lawrence Wickerham, Worta J McCaskill-Stevens
Selective estrogen receptor modulators (SERMs) reduce breast cancer risk. Adoption of SERMs as prevention medication remains low. This is the first study to quantify social, cultural, and psychologic factors driving decision making regarding SERM use in women counseled on breast cancer prevention options. A survey study was conducted with women counseled by a health care provider (HCP) about SERMs. A statistical comparison of responses was performed between those who decided to use and those who decided not to use SERMs...
October 4, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28973719/identification-of-differentially-expressed-genes-in-pathways-of-cerebral-neurotransmission-of-anovulatory-mice
#13
M A Azevedo, I D C G Silva
Polycystic ovary syndrome is the classic example of loss of functional cyclicity and anomalous feedback. In this case, the excessive extra-glandular production and conversion of androgens to estrogens are the pathophysiological basis of the chronic anovulation. The literature describes an experimental model of the polymicrocystic ovary in obese diabetic mice with insulin resistance. The fact that these animals exhibit obesity, insulin resistance, and infertility demonstrates their skill as an experimental model for polycystic ovary...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28969048/rna-seq-based-gene-expression-analysis-of-ovarian-granulosa-cells-exposed-to-zearalenone-in-vitro-significance-to-steroidogenesis
#14
Guo-Liang Zhang, Rui-Qian Zhang, Xiao-Feng Sun, Shun-Feng Cheng, Yu-Feng Wang, Chuan-Liang Ji, Yan-Zhong Feng, Jie Yu, Wei Ge, Yong Zhao, Shi-Duo Sun, Wei Shen, Lan Li
Zearalenone (ZEA) is a natural contaminant of various food and feed products representing a significant problem worldwide. Since the occurrence of ZEA in grains and feeds is frequent, the present study was carried out to evaluate the possible effects of ZEA on steroid production and gene expression of porcine granulosa cells, using RNA-seq analysis. Porcine granulosa cells were administered 10 μM and 30 μM ZEA during 72 h of culture in vitro. Following ZEA treatment the gene expression profile of control and exposed granulosa cells was compared using RNA-seq analysis...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968647/genetic-deletion-of-sphingosine-kinase-1-suppresses-mouse-breast-tumor-development-in-a-her2-transgenic-model
#15
Yoshiko Shimizu, Hideki Furuya, Paulette M Tamashiro, Kayoko Iino, Owen T M Chan, Steve Goodison, Ian Pagano, Kanani Hokutan, Rafael Peres, Lenora W M Loo, Brenda Hernandez, Aung Naing, Clayton D K Chong, Charles J Rosser, Toshihiko Kawamori
Aberrant sphingolipid metabolism has been reported to promote breast cancer progression. Sphingosine kinase 1 (SphK1) is a key metabolic enzyme for the formation of pro-survival S1P from pro-apoptotic ceramide. The role of SphK1 in breast cancer has been well studied in estrogen receptor (ER)-positive breast cancer, however, its role in human epidermal growth factor 2 (HER2)-positive breast cancer remains unclear. Here we show that genetic deletion of SphK1 significantly reduced mammary tumor development with reduced tumor incidence and multiplicity in the MMTV-neu transgenic mouse model...
September 11, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28957760/comprehensive-evaluation-of-three-sets-of-advanced-wastewater-treatment-trains-for-treating-secondary-effluent-organic-micro-pollutants-and-bio-toxicity
#16
Zhiqiang Chen, Mo Li, Qinxue Wen
The environmental presence of organic micro-pollutants (OMPs) has posed increasing risks on aquatic organism and human health. The performance of three commonly used advanced wastewater treatment trains, coagulation-sand filter, coagulation-biological aerated filter (BAF) and ozonation-biological activated carbon (BAC), in removing fifteen residual contaminants and bio-toxicity of the effluent from a local municipal wastewater treatment plant (WWTP) were investigated. Relatively high level of OMPs (0.69-14...
September 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28955742/bisphenol-a-inhibits-compound-action-potentials-in-the-frog-sciatic-nerve-in-a-manner-independent-of-estrogen-receptors
#17
Kotaro Mizuta, Tsugumi Fujita, Hiroki Yamagata, Eiichi Kumamoto
Although the endocrine disruptor bisphenol A (BPA) is reported to inhibit nerve conduction, the underlying mechanisms are unclear. Therefore, in the present study, we examined the effect of BPA on compound action potentials (CAPs) recorded from the frog sciatic nerve using the air-gap method. Treatment of the sciatic nerve with BPA (0.5 mM) for 20 min reduced the peak amplitude of the CAP by approximately 60% in a partially reversible manner. The reduction in the CAP peak amplitude was concentration-dependent, with a half-maximal inhibitory concentration (IC50) value of 0...
July 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28947133/palbociclib-induced-autophagy-and-senescence-in-gastric-cancer-cells
#18
Claudio A Valenzuela, Leandro Vargas, Valentina Martinez, Sindy Bravo, Nelson E Brown
Targeting cyclin D-CDK4/6 kinase complexes has recently been shown to increase the survival of breast cancer patients with estrogen receptor positive breast tumors. Based on these outcomes, CDK4/6 inhibitors are currently being tested, alone o in combination with other drugs, in the treatment of other malignancies characterized by hyper-activation of cyclin D-CDK4/6 complexes. Nonetheless, a better understanding of the cellular processes that are implemented in response to CDK4/6 inhibition is necessary to expand the therapeutic window and confront the development of drug resistance...
September 23, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28943990/motivators-and-barriers-of-tamoxifen-use-as-risk-reducing-medication-amongst-women-at-increased-breast-cancer-risk-a-systematic-literature-review
#19
REVIEW
B Meiser, W K T Wong, M Peate, C Julian-Reynier, J Kirk, G Mitchell
BACKGROUND: Selective estrogen receptor modulators, such as tamoxifen, reduce breast cancer risk by up to 50% in women at increased risk for breast cancer. Despite tamoxifen's well-established efficacy, many studies show that most women are not taking up tamoxifen. This systematic literature review aimed to identify the motivators and barriers to tamoxifen use 's amongst high-risk women. METHODS: Using MEDLINE, PsycINFO, and Embase plus reviewing reference lists of relevant articles published between 1995 and 2016, 31 studies (published in 35 articles) were identified, which addressed high-risk women's decisions about risk-reducing medication to prevent breast cancer and were peer-reviewed primary clinical studies...
2017: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/28939933/cellular-mechanics-of-primary-human-cervical-fibroblasts-influence-of-progesterone-and-a-pro-inflammatory-cytokine
#20
Vasudha Shukla, Victoria Barnhouse, William E Ackerman, Taryn L Summerfield, Heather M Powell, Jennifer L Leight, Douglas A Kniss, Samir N Ghadiali
The leading cause of neonatal mortality, pre-term birth, is often caused by pre-mature ripening/opening of the uterine cervix. Although cervical fibroblasts play an important role in modulating the cervix's extracellular matrix (ECM) and mechanical properties, it is not known how hormones, i.e., progesterone, and pro-inflammatory insults alter fibroblast mechanics, fibroblast-ECM interactions and the resulting changes in tissue mechanics. Here we investigate how progesterone and a pro-inflammatory cytokine, IL-1β, alter the biomechanical properties of human cervical fibroblasts and the fibroblast-ECM interactions that govern tissue-scale mechanics...
September 22, 2017: Annals of Biomedical Engineering
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