Jean Ye, Saloni Mehta, Hannah Peterson, Ahmad Ibrahim, Gul Saeed, Sarah Linsky, Iouri Kreinin, Sui Tsang, Uzoji Nwanaji-Enwerem, Anthony Raso, Jagriti Arora, Fuyuze Tokoglu, Sarah W Yip, C Alice Hahn, Cheryl Lacadie, Abigail S Greene, R Todd Constable, Declan T Barry, Nancy S Redeker, Henry Yaggi, Dustin Scheinost
OBJECTIVES: Opioid use disorder (OUD) impacts millions of people worldwide. The prevalence and debilitating effects of OUD present a pressing need to understand its neural mechanisms to provide more targeted interventions. Prior studies have linked altered functioning in large-scale brain networks with clinical symptoms and outcomes in OUD. However, these investigations often do not consider how brain responses change over time. Time-varying brain network engagement can convey clinically relevant information not captured by static brain measures...
February 27, 2024: medRxiv