keyword
https://read.qxmd.com/read/38531584/intercostal-nerve-cryoablation-versus-thoracic-epidural-analgesia-for-minimal-invasive-nuss-repair-of-pectus-excavatum-a-protocol-for-a-randomised-clinical-trial-ice-trial
#1
JOURNAL ARTICLE
Nicky Janssen, Jean H T Daemen, Aimée J P M Franssen, Elise J van Polen, Lori M van Roozendaal, Karel W E Hulsewé, Yvonne Vissers, Erik R de Loos
INTRODUCTION: Epidural analgesia is currently considered the gold standard in postoperative pain management for the minimally invasive Nuss procedure for pectus excavatum. Alternative analgesic strategies (eg, patient-controlled analgesia and paravertebral nerve block) fail in accomplishing adequate prolonged pain management. Furthermore, the continuous use of opioids, often prescribed in addition to all pain management strategies, comes with side effects. Intercostal nerve cryoablation seems a promising novel technique...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38528975/virtual-focus-groups-among-individuals-with-use-disorders-assessing-feasibility-and-acceptability-in-an-underserved-clinical-population
#2
JOURNAL ARTICLE
Cecilia L Bergeria, Brandon Park, Prem Umang Satyavolu, Kelly E Dunn, Robert H Dworkin, Eric C Strain
OBJECTIVE: There are substantial barriers to conducting research among individuals with stigmatized and complicated health conditions like substance use disorders. These barriers slow progress when developing, refining, and assessing interventions to better treat underserved populations. Virtual focus groups are an innovative method for collecting data from individuals via a discreet and accessible platform which can inform novel as well as existing treatment approaches. This article reports on the feasibility and acceptability of virtual focus groups as a mechanism to recruit and engage geographically and demographically diverse samples of participants with substance use disorders that are otherwise logistically difficult to assess...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38525593/perspectives-of-canadian-healthcare-and-harm-reduction-workers-on-mobile-overdose-response-services-a-qualitative-study
#3
JOURNAL ARTICLE
Navid Sedaghat, Boogyung Seo, Nathan Rider, William Rioux, S Monty Ghosh
BACKGROUND: Supervised consumption sites (SCS) are an evidence-based intervention proven effective for preventing drug overdose deaths. Obstacles to accessing SCS include stigma, limited hours of operation, concerns about policing, and limited geographic availability. Mobile overdose response services (MORS) are novel technologies that provide virtual supervised consumption to help reduce the risk of fatal overdoses, especially for those who use alone. MORS can take various forms, such as phone-based hotlines and mobile apps...
March 25, 2024: Subst Use Addctn J
https://read.qxmd.com/read/38524086/kratom-induced-psychiatric-decompensation-and-paranoid-delusions
#4
Matthew Awad, Hugh H Burke, Scott A Oakman
Kratom is a plant extract readily available for purchase in the USA. It is known to produce both stimulant and opioid-related effects, predisposing it to abuse. The long-term effects of kratom are poorly understood. In rare cases, serious side effects have been reported. Here, we report a case of a patient with a history of bipolar type schizoaffective disorder presenting with acute onset paranoia and delusions. The patient had been hospitalized seven times previously with psychotic symptoms, with no reported history of paranoid delusional thought content in previous admissions...
February 2024: Curēus
https://read.qxmd.com/read/38523636/case-report-successful-induction-of-buprenorphine-in-medically-complex-patients-concurrently-on-opioids-a-case-series-at-a-tertiary-care-center
#5
Thomas Shelton, Sharanya Nama, Orman Hall, Margaret Williams
Effective pain management is essential for optimal surgical outcomes; however, it can be challenging in patients with a history of opioid use disorder (OUD). Buprenorphine, a partial opioid agonist, is a valuable treatment option for patients with OUD. Initiating buprenorphine treatment in patients concurrently taking opioids can be complex due to potential adverse outcomes like precipitated withdrawal. Evolving guidelines suggest there are benefits to continuing buprenorphine for surgical patients throughout the perioperative period, however situations do arise when buprenorphine has been discontinued...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38522114/guanidine-to-piperidine-switch-affords-high-affinity-small-molecule-npff-ligands-with-preference-for-npff1-r-and-npff2-r-subtypes
#6
JOURNAL ARTICLE
Kareem A Galal, Samuel Obeng, Victoria L C Pallares, Alexandria Senetra, Maria A B L Seabra, Ahmed Awad, Christopher R McCurdy
The Neuropeptide FF (NPFF) receptor system is known to modulate opioid actions and has been shown to mediate opioid-induced hyperalgesia and tolerance. The lack of subtype selective small molecule compounds has hampered further exploration of the pharmacology of this receptor system. The vast majority of available NPFF ligands possess a highly basic guanidine group, including our lead small molecule, MES304. Despite providing strong receptor binding, the guanidine group presents a potential pharmacokinetic liability for in vivo pharmacological tool development...
March 23, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38517751/evidence-for-the-induction-of-analgesic-cross-tolerance-between-opioid-and-apelin-apj-systems-in-male-rats
#7
JOURNAL ARTICLE
Elham Abbasloo, Saeed Esmaeili-Mahani, Firas Kobeissy, Theresa Currier Thomas
BACKGROUND: Opioids are potent pain relievers for managing severe pain. However, their effectiveness is hindered by tolerance, which causes the need for higher doses and leads to adverse effects. In a previous study, we found that prolonged use of apelin, similar to opioids, results in a tolerance to its analgesic effects. It remains unclear whether there is a cross-tolerance between morphine and apelin, meaning if the analgesic effects of one can reduce the effectiveness of the other...
March 22, 2024: Journal of Studies on Alcohol and Drugs
https://read.qxmd.com/read/38514005/food-preference-based-screening-method-for-identification-of-effectors-of-substance-use-disorders-using-caenorhabditis-elegans
#8
JOURNAL ARTICLE
Aaron Taehwan Kim, Sida Li, Yoo Kim, Young-Jai You, Yeonhwa Park
Substance use disorder (SUD) affects over 61 million Americans aged 12 and over. Thus, identifying novel chemicals contributing to SUD will be critical for developing efficient prevention and mitigation strategies. Considering the complexity of the actions and effects of these substances on human behavior, a high-throughput platform using a living organism is ideal. We developed a quick and easy screening assay using Caenorhabditis elegans. C. elegans prefers high-quality food (Escherichia coli HB101) over low-quality food (Bacillus megaterium), with a food preference index of approximately 0...
March 19, 2024: Life Sciences
https://read.qxmd.com/read/38511523/clinical-evaluation-of-pf614-a-novel-taap-prodrug-of-oxycodone-versus-oxycontin-in-a-multi-ascending-dose-study-with-a-bioequivalence-arm-in-healthy-volunteers
#9
JOURNAL ARTICLE
D Lynn Kirkpatrick, Cari Evans, Linda A Pestano, Jeffrey Millard, Matthew Johnston, Emily Mick, William K Schmidt
PF614, a trypsin-activated abuse protection oxycodone prodrug designed to reduce recreational drug abuse, was compared to OxyContin for safety and pharmacokinetics (PKs) of plasma oxycodone following oral administration. This study was a two-part design including a multi-ascending dose (part A) and a bioequivalence (BE) study (part B) in healthy volunteers. In part A, 24 subjects were randomized 3:1 to receive PF614 (50, 100, or 200 mg, n = 6/cohort) or OxyContin (20, 40, or 80 mg; n = 2/cohort) in ascending cohorts, delivered every 12 h for a total of nine doses...
March 2024: Clinical and Translational Science
https://read.qxmd.com/read/38502911/withdrawal-catastrophizing-scale-initial-psychometric-properties-and-implications-for-the-study-of-opioid-use-disorder-and-hyperkatifeia
#10
JOURNAL ARTICLE
Orman Trent Hall, Michael Vilensky, Julie E Teater, Craig Bryan, Kara Rood, Julie Niedermier, Parker Entrup, Stephanie Gorka, Anthony King, David A Williams, K Luan Phan
Background: Discovery of modifiable factors influencing subjective withdrawal experience might advance opioid use disorder (OUD) research and precision treatment. This study explores one factor - withdrawal catastrophizing - a negative cognitive and emotional orientation toward withdrawal characterized by excessive fear, worry or inability to divert attention from withdrawal symptoms. Objectives: We define a novel concept - withdrawal catastrophizing - and present an initial evaluation of the Withdrawal Catastrophizing Scale (WCS)...
March 19, 2024: American Journal of Drug and Alcohol Abuse
https://read.qxmd.com/read/38500003/a-qualitative-exploration-of-the-use-of-telehealth-for-opioid-treatment-implications-for-nurse-managed-care
#11
JOURNAL ARTICLE
Omeid Heidari, Abigail K Winiker, Sarah Pollock, Shereen Sodder, Judith I Tsui, Karin E Tobin
AIM: To characterise experiences with telehealth for Medications for Opioid Use Disorder (MOUD) services among patients, prescribers, nurses and substance use counsellors to inform future best practices. DESIGN: We engaged a qualitative descriptive study design. METHODS: Semi-structured interviews were conducted with prescribers (nurse practitioners and physicians, n = 20), nurses and substance use counsellors (n = 7), and patients (n = 20) between June and September 2021...
March 18, 2024: Journal of Clinical Nursing
https://read.qxmd.com/read/38499943/ultrasound-guided-external-oblique-intercostal-plane-block-for-postoperative-analgesia-in-laparoscopic-sleeve-gastrectomy-a-prospective-randomized-controlled-patient-and-observer-blinded-study
#12
JOURNAL ARTICLE
Ali Sait Kavakli, Taylan Sahin, Umit Koc, Arzu Karaveli
PURPOSE: The external oblique intercostal plane (EOI) block is a novel block technique for anterolateral upper abdominal wall analgesia. The superficial nature of the external oblique intercostal plane allows it to be easily identified even in patients with obesity. The aim of this study was to test the hypothesis that EOI block would reduce IV morphine consumption within 24 h after laparoscopic sleeve gastrectomy. MATERIALS AND METHODS: Patients were randomly assigned to one of two groups: EOI block group and control group...
March 18, 2024: Obesity Surgery
https://read.qxmd.com/read/38499497/multiscale-topology-in-interactomic-network-from-transcriptome-to-antiaddiction-drug-repurposing
#13
JOURNAL ARTICLE
Hongyan Du, Guo-Wei Wei, Tingjun Hou
The escalating drug addiction crisis in the United States underscores the urgent need for innovative therapeutic strategies. This study embarked on an innovative and rigorous strategy to unearth potential drug repurposing candidates for opioid and cocaine addiction treatment, bridging the gap between transcriptomic data analysis and drug discovery. We initiated our approach by conducting differential gene expression analysis on addiction-related transcriptomic data to identify key genes. We propose a novel topological differentiation to identify key genes from a protein-protein interaction network derived from DEGs...
January 22, 2024: Briefings in Bioinformatics
https://read.qxmd.com/read/38494051/engagement-initiation-and-retention-in-medication-treatment-for-opioid-use-disorder-among-young-adults-a-narrative-review-of-challenges-and-opportunities
#14
JOURNAL ARTICLE
Marc Fishman, Kevin Wenzel, Phoebe Gauthier, Jacob Borodovsky, Owen Murray, Geetha Subramaniam, Sharon Levy, Emma Fredyma, Bethany McLeman, Lisa A Marsch
INTRODUCTION: Opioid Use Disorder (OUD) is a catastrophic public health problem for young adults (YAs) and their families. While medication for OUD (MOUD) is safe, effective, and recognized as the standard of care, its' uptake and success have been limited in YAs compared to older adults. METHODS: This narrative review summarizes the existing literature and highlights select studies regarding barriers to YA MOUD, potential explanations for those barriers, and strategies to overcome them...
March 15, 2024: J Subst Use Addict Treat
https://read.qxmd.com/read/38482650/on-the-opioid-crisis-an-interview-with-vincent-lam
#15
JOURNAL ARTICLE
Neil Stuart, Anne Wojtak
Vincent Lam, the author of the best-selling novels Bloodletting & Miraculous Cures (Lam 2006) and The Headmaster's Wager (Lam 2012), recently spoke with the editors of Healthcare Quarterly (HQ), Neil Stuart and Anne Wojtak, about his new novel On the Ravine (Lam 2023). The novel explores the nuances of substance abuse and its impacts on patients and the people in their lives.
January 2024: Healthcare Quarterly
https://read.qxmd.com/read/38481688/characterization-of-a-nonselective-opioid-receptor-functional-antagonist-implications-for-development-as-a-novel-opioid-dependence-medication
#16
JOURNAL ARTICLE
Siavash Shahbazi Nia, Yuma T Ortiz, Julio D Zuarth Gonzalez, Leila Shamir, Kofi Frimpong-Manson, Mohammad Anwar Hossain, Sadisna Shahi, Rayna Bandy, Anoushka Bhat, Dhavalkumar Patel, Hanin Diab, Jonathan Thompson, Lance R McMahon, Jenny L Wilkerson, Nadezhda A German
Opioids represent the most extensive category of abused substances in the United States, and the number of fatalities caused by these drugs exceeds those associated with all other drug overdoses combined. The administration of naltrexone, a potent pan-opioid receptor antagonist, to an individual dependent on opioids can trigger opioid withdrawal and induce severe side effects. There is a pressing demand for opioid antagonists free of opioid withdrawal effects. In our laboratory, we have identified a compound with affinity to mu, delta, and kappa opioid receptors in the range of 150-250 nM...
March 8, 2024: ACS Pharmacology & Translational Science
https://read.qxmd.com/read/38481624/make-me-more-comfortable-effects-of-a-hypnosis-session-on-pain-perception-in-chronic-pain-patients
#17
JOURNAL ARTICLE
David Ogez, Mathieu Landry, Rémi Caron-Trahan, Anne-Eva Jusseaux, Maryse Aubin, Jade Véronneau, Valentyn Fournier, Nadia Godin, Moulay Idrissi, Pierre Rainville, Philippe Richebé
INTRODUCTION: Approximately one-quarter of Canadians experience chronic pain, a debilitating condition often necessitating opioid use, which raises concerns regarding dependency and overdose risks. As an alternative, we developed the HYlaDO program (Hypnose de la Douleur, hypnosis of Pain in French), a novel self-hypnosis approach for chronic pain management. The development of this program followed the ORBIT model, a comprehensive framework for designing interventions encompassing several phases ranging from design to efficacy assessment...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38481543/practices-and-outcomes-associated-with-sublingual-buprenorphine-use-in-a-critically-ill-population
#18
JOURNAL ARTICLE
Denis J Vanini, Jenna M Corvelli, Kaylee M Maynard, Stephen H Rappaport, Gina Grasso, Raquel Jones, Nicole M Acquisto, Rachel F Schult
IMPORTANCE: Buprenorphine for opioid use disorder (OUD) is commonly used in the outpatient setting with increasing use in hospitalized patients. However, there is limited literature describing its use in critically ill populations. OBJECTIVES: The primary objective was to report the practices of buprenorphine prescribing among ICU teams. We also assessed the effect of a novel initiation strategy on opioid requirements in the ICU and the incidence of precipitated withdrawal...
March 2024: Critical care explorations
https://read.qxmd.com/read/38466029/metabolomic-profiling-of-pediatric-post-tonsillectomy-pain-a%C3%A2-proof-of-concept-study
#19
JOURNAL ARTICLE
Christian Mpody, Ambrish B Patel, William E Smoyer, Joseph D Tobias, Olubukola O Nafiu
INTRODUCTION: Tonsillectomies are among the most common surgical procedures in children, with over 500 000 cases annually in the United States. Despite universal administration of intraoperative opioid analgesia, three out of five children undergoing tonsillectomy report moderate-to-severe pain upon recovering from anesthesia. The underlying molecular mechanisms of post-tonsillectomy pain are not well understood, limiting the development of targeted treatment strategies. Our study aimed to identify candidate serum metabolites associated with varying severity of post-tonsillectomy pain...
March 11, 2024: Paediatric Anaesthesia
https://read.qxmd.com/read/38464297/investigating-brain-dynamics-and-their-association-with-cognitive-control-in-opioid-use-disorder-using-naturalistic-and-drug-cue-paradigms
#20
Jean Ye, Saloni Mehta, Hannah Peterson, Ahmad Ibrahim, Gul Saeed, Sarah Linsky, Iouri Kreinin, Sui Tsang, Uzoji Nwanaji-Enwerem, Anthony Raso, Jagriti Arora, Fuyuze Tokoglu, Sarah W Yip, C Alice Hahn, Cheryl Lacadie, Abigail S Greene, R Todd Constable, Declan T Barry, Nancy S Redeker, Henry Yaggi, Dustin Scheinost
OBJECTIVES: Opioid use disorder (OUD) impacts millions of people worldwide. The prevalence and debilitating effects of OUD present a pressing need to understand its neural mechanisms to provide more targeted interventions. Prior studies have linked altered functioning in large-scale brain networks with clinical symptoms and outcomes in OUD. However, these investigations often do not consider how brain responses change over time. Time-varying brain network engagement can convey clinically relevant information not captured by static brain measures...
February 27, 2024: medRxiv
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