keyword
MENU ▼
Read by QxMD icon Read
search

GHB

keyword
https://www.readbyqxmd.com/read/29905804/relationship-between-postmortem-urine-and-blood-concentrations-of-ghb-furnishes-useful-information-to-help-interpret-drug-intoxication-deaths
#1
A W Jones, A Holmgren, F C Kugelberg, F P Busardò
This article reports the concentrations of gamma-hydroxybutyrate (GHB) in femoral blood and bladder urine in a case series of drug intoxication deaths (N = 37). GHB was determined in blood (B-GHB) and urine (U-GHB) by a GC-FID-GBL method and 30 mg/L was used as a cut-off concentration for reporting positive results. The mean (median) and range of GHB concentrations in bladder urine were 2,818 mg/L (1,900 mg/L) and 120-13,000 mg/L, respectively. These concentrations were appreciably higher than those in femoral blood, 637 mg/L (260 mg/L) and 30-9,200 mg/L, respectively...
June 14, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29859447/assessing-the-longitudinal-stability-of-latent-classes-of-substance-use-among-gay-bisexual-and-other-men-who-have-sex-with-men
#2
Kiffer G Card, Heather L Armstrong, Allison Carter, Zishan Cui, Lu Wang, Julia Zhu, Nathan J Lachowsky, David M Moore, Robert S Hogg, Eric A Roth
BACKGROUND: Association between substance use and HIV-risk among gay and bisexual men (GBM) is well documented. However, their substance use patterns are diverse, and it is unknown whether self-reported use patterns are stable over time. METHODS: Sexually-active GBM, aged >16 years, were recruited in Metro Vancouver using respondent-driven sampling and followed across 5 study visits at six-month intervals (n = 449). To identify distinct patterns of substance use and their longitudinal stability, Latent Transition Analysis (LTA) was conducted for drugs reported by at least 30 participants...
May 22, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29783276/somnophilia-and-sexual-abuse-through-the-administration-of-ghb-and-gbl
#3
Mark Pettigrew
Somnophilia, the desire to have sex with an unconscious, sleeping, or comatose person who is unable to respond, is a sexual paraphilia that is seldom reported. The underlying desire is often overshadowed by the act of sexual violation and when using GHB or GBL to induce unconsciousness, as in the case presented here, the victim might not even be able to recall, for certain, that they have been sexually violated. A case study is offered of a somnophile who adulterated drinks to render young men unconscious, so he could rape them in that state, before progressing to administering drugs anally on the pretext of applying lubrication to the anus to facilitate sexual intercourse...
May 21, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29778770/age-related-prevalence-and-twelve-month-incidence-of-illicit-drug-use-in-a-cohort-of-australian-gay-and-bisexual-men-results-from-the-flux-study
#4
Fengyi Jin, Mohamed A Hammoud, Lisa Maher, Louisa Degenhardt, Adam Bourne, Toby Lea, Stefanie Vaccher, Jeffrey Grierson, Bridget Haire, Garrett P Prestage
BACKGROUND: We report prevalence and incidence of drug use initiation in Australian gay and bisexual men (GBM) participating in an online cohort study. METHODS: Between September 2014 and June 2015, 1,710 GBM were enrolled in the Following Lives Undergoing Change Study and followed-up six monthly. Participants were asked about measures of lifetime use at baseline and recent use (last six months) at all visits. Drug use initiation was defined as men who reported having never used a specific drug prior to baseline and reported recent use at follow-up...
May 12, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29704206/protective-effect-of-rosa-damascena-against-aluminum-chloride-induced-oxidative-stress
#5
Zeinab Zahedi-Amiri, Ali Taravati, Leila Beigom Hejazian
Aluminum is considered an essential element endowed with toxicity potentials in human and animal. Thus, intoxication with aluminum can lead to oxidative stress, which is associated with oxidative damage to various macromolecules. Moreover, antioxidants from natural sources can play an important role in human health. Accordingly, the purpose of this study was to investigate the protective effect of Rosa damascena extract against aluminum-induced oxidative stress. In this study, 60 male rats were randomly divided into six groups and then they were given daily aluminum chloride and Rosa damascena extract...
April 27, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29702337/correlates-and-subgroups-of-injecting-drug-use-in-uk-gay-and-bisexual-men-findings-from-the-2014-gay-men-s-sex-survey
#6
G J Melendez-Torres, Adam Bourne, Ford Hickson, David Reid, Peter Weatherburn
BACKGROUND: Evidence to understand which gay and bisexual men (GBM) inject drugs remains scant, especially in the UK. We describe correlates of last-year injecting in UK GBM, and characterise subgroups of GBM who inject drugs by types of drugs used. METHODS: Using data from the 2014 Gay Men's Sex Survey, an opportunistic internet-based survey conducted of GBM living in the UK, we examined via logistic regression correlates with any injecting of six drugs (amphetamine/speed, crystal methamphetamine, heroin, mephedrone, GHB/GBL, and ketamine) in the last year...
June 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29683847/psychoactive-substances-alcohol-and-tobacco-consumption-in-hiv-infected-outpatients
#7
Jean-Marc Jacquet, Hélène Peyriere, Alain Makinson, Marianne Peries, Nicolas Nagot, Hélène Donnadieu-Rigole, Jacques Reynes
OBJECTIVES: To assess the alcohol consumption, tobacco addiction and psychoactive substance use (PSU) of people living with HIV (PLHIV). DESIGN: Cross-sectional study in an HIV outpatient unit. METHODS: Autoquestionnaire systematically proposed to all patients during their usual clinical care visit during a 6-months period, for alcohol (AUDIT test), tobacco (Short Fagerstrom Test) and PSU (ASSIST V3.0 test). RESULTS: Of 1334 distributed questionnaires, 1018 PLHIV responded: 76...
June 1, 2018: AIDS
https://www.readbyqxmd.com/read/29670663/the-effect-of-sanggua-drink-extract-on-insulin-resistance-through-the-pi3k-akt-signaling-pathway
#8
Yu Cai, Ying Wang, Fei Zhi, Qi-Chang Xing, Yun-Zhong Chen
Treating type 2 diabetes mellitus (T2DM) using thiazolidinediones and biguanides can present several challenges for patients. Sanggua Drink (SGD) is a commonly used agent in traditional Chinese medicine, and it consists of Folium Mori , Fructus Momordicae Charantiae , Radix Puerariae Lobatae , and Rhizoma Dioscorea . The hypoglycemic effects and mechanisms of SGD extracts on insulin resistance in diabetic rats were investigated. SGD (1.24 g/kg orally) was verified in T2DM rats induced by a high-fat diet and streptozotocin...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29668345/prevalence-and-psychosocial-correlates-of-party-drug-use-and-associated-problems-among-university-students-in-the-netherlands
#9
Laura E Kunst, Winifred A Gebhardt
BACKGROUND: Recent developments in drug use patterns call for an investigation of current party-drug use and associated problems among college students, who appear to be an important target population for harm reduction interventions. OBJECTIVES: In addition to reporting on party-drug use prevalence, we investigated whether initial use and continuation of party-drug use among students was associated with demographic, personality and psychosocial factors. METHODS: An online questionnaire was administered to 446 students from a Dutch university, inquiring about party-drug use, demographic characteristics, social norms and personality (big five, impulsiveness, aggression)...
April 18, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29651711/baclofen-to-prevent-relapse-in-gamma-hydroxybutyrate-ghb-dependent-patients-a-multicentre-open-label-non-randomized-controlled-trial
#10
Harmen Beurmanjer, Rama M Kamal, Cor A J de Jong, Boukje A G Dijkstra, Arnt F A Schellekens
BACKGROUND: Gamma-hydroxybutyrate (GHB) dependence is associated with a severe, potentially lethal, withdrawal syndrome and relapse rates as high as 60% within 3 months of detoxification. Baclofen has been shown to decrease self-administration of GHB in mice and reduce relapse in a case series of GHB-dependent patients. Controlled studies on the effectiveness of baclofen to prevent relapse in GHB-dependent patients are lacking. AIM: The aim of this study was to assess effectiveness of baclofen in preventing relapse in GHB-dependent patients...
May 2018: CNS Drugs
https://www.readbyqxmd.com/read/29625796/sexualised-drug-use-in-the-united-kingdom-uk-a-review-of-the-literature
#11
Claire Edmundson, Ellen Heinsbroek, Rachel Glass, Vivian Hope, Hamish Mohammed, Martin White, Monica Desai
BACKGROUND: Sexualised drug use (SDU) refers to the use of drugs in a sexual context. This includes 'Chemsex'- the use of drugs (specifically crystal methamphetamine, GHB/GBL and mephedrone) before or during planned sexual activity to sustain, enhance, disinhibit or facilitate the experience. Here we aimed to synthesise available UK prevalence data for Chemsex, SDU and the use of Chemsex drugs in an undefined context (CDU) in men who have sex with men (MSM). METHODS: Papers published between January 2007 and August 2017 reporting Chemsex, SDU and/or Chemsex drug use (CDU) prevalence in MSM were identified through PubMed...
May 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29524621/gamma-hydroxybutyrate-increases-brain-resting-state-functional-connectivity-of-the-salience-network-and-dorsal-nexus-in-humans
#12
Oliver G Bosch, Fabrizio Esposito, Dario Dornbierer, Michael M Havranek, Robin von Rotz, Michael Kometer, Philipp Staempfli, Boris B Quednow, Erich Seifritz
According to the triple network hypothesis the brain is equipped with three core neurocognitive networks: the default mode (DMN), the salience (SN), and the central executive (CEN) network. Moreover, the so called dorsal nexus, has met growing interest as it is a hub region connecting these three networks. Assessment of resting-state functional connectivity (rsFC) of these networks enables the elucidation of drug-induced brain alterations. Gamma-hydroxybutyrate (GHB) is a GHB/GABA-B receptor agonist that induces a paradoxical state of mixed stimulation and sedation at moderate doses, which makes it a valuable tool to investigate neural signatures of subjective drug effects...
June 2018: NeuroImage
https://www.readbyqxmd.com/read/29523484/patterns-of-injecting-and-non-injecting-drug-use-by-sexual-behaviour-in-people-who-inject-drugs-attending-services-in-england-wales-and-northern-ireland-2013-2016
#13
Ellen Heinsbroek, Rachel Glass, Claire Edmundson, Vivian Hope, Monica Desai
BACKGROUND: Higher levels of drug use have been reported in lesbian, gay, bisexual and transgender (LGBT) communities, some of which can be explained by sexualised drug use, including 'chemsex'; the use of drugs before or during planned sexual activity to sustain, enhance, disinhibit or facilitate sex. We explored injecting and non-injecting drug use by sexual behaviour among people who inject drugs (PWID) in England, Wales and Northern Ireland. METHODS: Data were used from an unlinked-anonymous survey of PWID (2013-2016), where participants recruited through services self-completed a questionnaire...
March 6, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29512449/sodium-oxybate-treatment-in-pediatric-type-1-narcolepsy
#14
Monica Moresco, Fabio Pizza, Elena Antelmi, Giuseppe Plazzi
Narcolepsy type 1 (NT1) is a rare chronic neurologic disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations and disrupted nocturnal sleep, usually with onset during childhood/adolescence. Pediatric NT1 is associated with limitations on children's activities and achievements, especially poor performance at school, difficulty with peers due to disease symptoms and comorbidities including depression, obesity, and precocious puberty. NT1 disease is caused by the selective loss of hypocretin-producing neurons in the lateral hypothalamus, most probably related to an autoimmune pathophysiology...
March 5, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29460030/succinic-semialdehyde-dehydrogenase-deficiency-a-disorder-of-gaba-metabolism-an-update-on-pharmacological-and-enzyme-replacement-therapeutic-strategies
#15
Kara R Vogel, Garrett R Ainslie, Dana C Walters, Alice McConnell, Sameer C Dhamne, Alexander Rotenberg, Jean-Baptiste Roullet, K Michael Gibson
We present an update to the status of research on succinic semialdehyde dehydrogenase (SSADH) deficiency (SSADHD), a rare disorder of GABA metabolism. This is an unusual disorder featuring the accumulation of both GABA and its neuromodulatory analog, gamma-hydroxybutyric acid (GHB), and recent studies have advanced the potential clinical application of NCS-382, a putative GHB receptor antagonist. Animal studies have provided proof-of-concept that enzyme replacement therapy could represent a long-term therapeutic option...
February 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29459773/erythrocyte-glutathione-transferase-in-kidney-transplantation-a-probe-for-kidney-detoxification-efficiency
#16
Alessio Bocedi, Annalisa Noce, Valentina Rovella, Giulia Marrone, Giada Cattani, Massimo Iappelli, Paolo De Paolis, Giuseppe Iaria, Daniele Sforza, Mariacarla Gallù, Giuseppe Tisone, Nicola Di Daniele, Giorgio Ricci
Erythrocyte glutathione transferase (e-GST) is overexpressed in case of increased blood toxicity and its level correlates with the kidney disease progression. Thus, it represents a probe of kidney efficiency against circulating toxins. We measured the activity of e-GST in patients with transplant kidney from living and cadaver donors, correlated its level to biochemical parameters of kidney function, and measured the level of oxidized albumin as a probe of oxidative stress using a new simple procedure. Interestingly, the activity of e-GST in transplant patients from cadaver donors (N = 153) is very high (11...
February 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29448841/the-association-of-serum-iron-binding-proteins-and-the-antioxidant-parameter-levels-in-age-related-macular-degeneration
#17
Emina Čolak, Lepša Žorić, Aleksandra Radosavljević, Svetlana Ignjatović
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD...
May 2018: Current Eye Research
https://www.readbyqxmd.com/read/29427917/hiv-treatment-optimism-and-crystal-methamphetamine-use-and-initiation-among-hiv-negative-men-who-have-sex-with-men-in-vancouver-canada-a-longitudinal-analysis
#18
Sean P Colyer, Nathan J Lachowsky, Zishan Cui, Julia Zhu, Heather L Armstrong, Matthew Taylor, Joshua Edward, Gbolahan Olarewaju, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: Treatment as Prevention (TasP) leading to increased HIV treatment optimism among men who have sex with men (MSM) has been previously associated with behavioural risk compensation, though not yet via crystal methamphetamine (CM) use. Among HIV-negative MSM in a TasP environment, this study aimed to investigate the prevalence of recent CM use over time, examine the association between HIV treatment optimism and CM use and initiation, and identify correlates of recent CM use and predictors of CM initiation...
April 1, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29402684/implications-of-survey-labels-and-categorisations-for-understanding-drug-use-in-the-context-of-sex-among-gay-and-bisexual-men-in-melbourne-australia
#19
Kathleen E Ryan, Anna L Wilkinson, Alisa Pedrana, Brendan Quinn, Paul Dietze, Margaret Hellard, Mark Stoové
BACKGROUND: Reliably measuring drug use by gay, bisexual and other men who have sex with men (GBM) in the context of sex can inform sexual health service responses. We report changing drug use patterns among GBM testing for HIV at a community-based service in Melbourne in response to behavioural survey modifications. METHODS: Surveys were completed by GBM prior to all HIV tests. Survey one asked about use of "party drugs for the purpose of sex" and survey two asked about specific drug use (alcohol, amyl nitrate, methamphetamine, cocaine, ecstasy, GHB, Viagra® /Cialis® ) before or during sex...
February 2, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29378270/d-ribose-induced-glycoxidative-insult-to-hemoglobin-protein-an-approach-to-spot-its-structural-perturbations
#20
Zeba Siddiqui, Mohd Ishtikhar, Moinuddin, Saheem Ahmad
Glycation of biological macromolecule leads to the establishment of advanced glycation end products (AGEs) having implications in metabolic disorders. d‑ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the glycation reactions in vivo, however, no report have been published yet to discuss d‑ribose induced glycation of hemoglobin (Hb). Therefore, the present study was designed to investigate d‑ribose induced glycoxidative damage to Hb protein. Briefly, the commercially available Hb was glycated with d‑ribose for varying time intervals...
June 2018: International Journal of Biological Macromolecules
keyword
keyword
73728
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"