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https://www.readbyqxmd.com/read/29448841/the-association-of-serum-iron-binding-proteins-and-antioxidant-parameter-levels-in-prelated-macular-degeneration
#1
Emina Čolak, Lepša Žorić, Aleksandra Radosavljević, Svetlana Ignjatović
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD...
February 15, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29427917/hiv-treatment-optimism-and-crystal-methamphetamine-use-and-initiation-among-hiv-negative-men-who-have-sex-with-men-in-vancouver-canada-a-longitudinal-analysis
#2
Sean P Colyer, Nathan J Lachowsky, Zishan Cui, Julia Zhu, Heather L Armstrong, Matthew Taylor, Joshua Edward, Gbolahan Olarewaju, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: Treatment as Prevention (TasP) leading to increased HIV treatment optimism among men who have sex with men (MSM) has been previously associated with behavioural risk compensation, though not yet via crystal methamphetamine (CM) use. Among HIV-negative MSM in a TasP environment, this study aimed to investigate the prevalence of recent CM use over time, examine the association between HIV treatment optimism and CM use and initiation, and identify correlates of recent CM use and predictors of CM initiation...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29402684/implications-of-survey-labels-and-categorisations-for-understanding-drug-use-in-the-context-of-sex-among-gay-and-bisexual-men-in-melbourne-australia
#3
Kathleen E Ryan, Anna L Wilkinson, Alisa Pedrana, Brendan Quinn, Paul Dietze, Margaret Hellard, Mark Stoové
BACKGROUND: Reliably measuring drug use by gay, bisexual and other men who have sex with men (GBM) in the context of sex can inform sexual health service responses. We report changing drug use patterns among GBM testing for HIV at a community-based service in Melbourne in response to behavioural survey modifications. METHODS: Surveys were completed by GBM prior to all HIV tests. Survey one asked about use of "party drugs for the purpose of sex" and survey two asked about specific drug use (alcohol, amyl nitrate, methamphetamine, cocaine, ecstasy, GHB, Viagra®/Cialis®) before or during sex...
February 2, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29378270/d-ribose-induced-glycoxidative-insult-to-hemoglobin-protein-an-approach-to-spot-its-structural-perturbations
#4
Zeba Siddiqui, Mohd Ishtikhar, Moinuddin, Saheem Ahmad
Glycation of biological macromolecule leads to the establishment of advanced glycation end products (AGEs) having implications in metabolic disorders. d‑ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the glycation reactions in vivo, however, no report have been published yet to discuss d‑ribose induced glycation of hemoglobin (Hb). Therefore, the present study was designed to investigate d‑ribose induced glycoxidative damage to Hb protein. Briefly, the commercially available Hb was glycated with d‑ribose for varying time intervals...
January 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29374287/-liquid-ecstasy-intoxication-ghb-is-more-prevalent-than-assumed-and-is-potentially-more-harmful
#5
M Richter
No abstract text is available yet for this article.
January 26, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29366411/effects-of-ghb-on-psychomotor-and-driving-performance
#6
Carmela Centola, Arianna Giorgetti, Simona Zaami, Raffaele Giorgetti
BACKGROUND: Gamma-hydroxybutyrate (γ-hydroxybutyrate or GHB) is a physiological compound of mammalians with specific receptors in central nervous system (CNS). Apart from an endogenous production, GHB is also an exogenous molecule found in pharmaceutical as well as in illicit formulations, and it shares the same binding sites and is. Products manufactured and spread in these two fields, whose borders are all but strictly defined and traced, differ for the in-vivo effects and for the potential of abuse...
January 23, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29348108/report-fast-chromatographic-screening-method-for-7-drugs-of-potential-threat-in-drug-facilitated-crimes
#7
Beril Anılanmert, Ibrahim Narın, Ibrahim Aydın, Munevver Acıkkol
In cases where pharmaceuticals and pharmaceutical candidates are involved in drug facilitated crimes (DFC), like organ theft, robbery, rape and suicides, the analysis of drug powders or solution residues found in crime scenes may give idea on what the victims have ingested. An easy and fast simultaneous determination of 7 drugs; GHB (γ-hydroxybutyrate), GBL (γ-butyrolactone), norketamine, ketamine, fenobarbital, fenitoin and thiopental which have the potential to be used in DFC was performed. The method required no sample preparation and has 12 minutes elution time with a good chromatographic separation...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29284546/medical-emergencies-related-to-ethanol-and-illicit-drugs-at-an-annual-nocturnal-indoor-electronic-dance-music-event
#8
Paul Calle, Nora Sundahl, Kristof Maudens, Sarah Mr Wille, Diederik Van Sassenbroeck, Koen De Graeve, Stefan Gogaert, Peter De Paepe, Dieter Devriese, Geert Arno, Peter Blanckaert
Introduction Medical problems are frequently encountered during electronic dance music (EDM) events. Problem There are uncertainties about the frequencies and severity of intoxications with different types of recreational drugs: ethanol, "classical" illicit party drugs, and new psychoactive substances (NPS). METHODS: Statistical data on the medical problems encountered during two editions of an indoor electronic dance event with around 30,000 attendants were retrieved from the Belgian Red Cross (Mechelen, Belgium) database...
December 29, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29280004/the-drug-of-abuse-gamma-hydroxybutyric-acid-exhibits-tissue-specific-nonlinear-distribution
#9
Melanie A Felmlee, Bridget L Morse, Kristin E Follman, Marilyn E Morris
The drug of abuse γ-hydroxybutyric acid (GHB) demonstrates complex toxicokinetics with dose-dependent metabolic and renal clearance. GHB is a substrate of monocarboxylate transporters (MCTs) which are responsible for the saturable renal reabsorption of GHB. MCT expression is observed in many tissues and therefore may impact the tissue distribution of GHB. The objective of the present study was to evaluate the tissue distribution kinetics of GHB at supratherapeutic doses. GHB (400, 600, and 800 mg/kg iv) or GHB 600 mg/kg plus L-lactate (330 mg/kg iv bolus followed by 121 mg/kg/h infusion) was administered to rats and blood and tissues were collected for up to 330 min post-dose...
December 26, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29260701/-treatment-of-gamma-hydroxybutyrate-withdrawal
#10
Niels August Willer Strand, Tonny Studsgaard Petersen, Lars Martin Nielsen, Soren Boegevig
Gamma-hydroxybutyrate (GHB) is a drug of abuse, for which physical addiction develops quickly. GHB withdrawal can develop into a life-threatening condition and has previously been treated mainly with benzodiazepines. These have not always proven effective, leading to long hospitalizations in intensive care units. Based on successful Dutch treatment results for using GHB to treat GHB withdrawal symptoms, we propose to implement a similar method in Denmark. The method requires an interdisciplinary effort for which The Danish Poison Information Centre should be consulted for expertise...
December 11, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29220733/a-fast-method-for-ghb-gluc-quantitation-in-whole-blood-by-gc-ms-ms-tqd-for-forensic-purposes
#11
Ana S Dias, André L Castro, Paula Melo, Sónia Tarelho, Pedro Domingues, João Miguel Franco
γ-Hydroxybutyric acid (GHB) is an endogenous compound with a historical use, both in licit and illicit terms. Importantly, the post-mortem behavior of GHB has been studied due to the possibility of using this compound as a biomarker for estimating the post-mortem interval (PMI). However, the post-mortem behavior of the recently discovered glucuronated GHB metabolite (GHB-GLUC) has not been studied. Nevertheless, GHB-GLUC may also have potential both to assist in PMI determination and also to increase the window of detection of GHB consumption...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29219048/sodium-oxybate-therapy-for-the-treatment-of-alcohol-withdrawal-syndrome-and-the-maintenance-of-alcohol-abstinence
#12
Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra, Gioacchino Calapai
BACKGROUND: Gamma-hydroxybutyrate (GHB or sodium oxybate) is both an exogenous and endogenous molecule with neuromodulator properties. In the United States, GHB is an approved drug for the treatment of narcolepsy and narcolepsy with cataplexy in adults. In some European Union countries, sodium oxybate is applied for the treatment of opioid and alcohol withdrawal. OBJECTIVE: The aim of the present review was to describe the state of art of the pre-clinical research and the clinical evidence related to GHB used alone or in combination with other treatments in alcohol withdrawal syndrome and alcohol abstinence maintenance...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29198063/baclofen-in-gamma-hydroxybutyrate-withdrawal-patterns-of-use-and-online-availability
#13
Christopher N Floyd, David M Wood, Paul I Dargan
PURPOSE: Gamma-hydroxybutyrate (GHB) withdrawal is a life-threatening condition that does not always respond to standard treatment with benzodiazepines. Baclofen has potential utility as a pharmacological adjunct and anecdotal reports suggest that it is being used by drug users to self-manage GHB withdrawal symptoms. Here, we investigate current patterns of use and the online availably of baclofen. METHODS: Data triangulation techniques were applied to published scientific literature and publicly accessible Internet resources (grey literature) to assess the use of baclofen in GHB withdrawal...
December 3, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29190073/response-to-comment-on-direct-monitoring-of-exogenous-ghb-in-body-fluids-by-nmr-spectroscopy-several-issues-to-consider-when-quantifying-ghb-in-biological-matrices
#14
Martina Palomino-Schätzlein, Alan David Brailsford, Teodor Parella, Míriam Pérez-Trujillo
In response to the letter from Pichini and Busardò, we would like to stress that we do not suggest NMR as an alternative technique to GC-MS or LC-MS, but complementary to them (which could provide additional valuable information), as was stated in the last sentence of the conclusions of the published article.
November 30, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29190070/comment-on-direct-monitoring-of-exogenous-ghb-in-body-fluids-by-nmr-spectroscopy-several-issue-to-consider-when-quantifying-ghb-in-biological-matrices
#15
Simona Pichini, Francesco Paolo Busardò
We have read with great interest the article of Palomino-Schätzlein and colleagues [1] entitled "Direct monitoring of exogenous GHB in body fluids by NMR spectroscopy", where the authors investigated the feasibility and suitability of NMR spectroscopy for the identification and quantification of exogenous GHB in urine and serum. In addition, the potential of NMR-based metabolomics for the identification of biomarkers indicative of GHB consumption was also evaluated. In our opinion, the study of Palomino-Schätzlein et al...
November 30, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29175521/structural-analysis-of-the-interaction-between-free-glycated-and-fructated-hemoglobin-with-propolis-nanoparticles-a-spectroscopic-study
#16
Fatemeh Kazemi, Adeleh Divsalar, Ali Akbar Saboury
Non enzymatic Glycation is the main causes of diabetic complications. Propolis is a natural product of different plant exudates and buds which has different biological properties such as anti-hyperglycemia. In attention to better performance of nanoparticles in treatment, we synthesized propolis nanoparticles (PNP) and analyzed their physicochemical properties by dynamic light scattering (DLS), scanning electron microscopy (SEM), Zeta potential and FTIR analyses. Then, the structural changes of human hemoglobin (Hb), in three different forms of free, glycated and fructated Hb upon interaction with PNP at two temperatures of 25 and 37°C were investigated using fluorescence and far-UV circular dichoroism (CD) spectroscopic techniques...
November 23, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29122285/determination-of-%C3%AE-hydroxybutyrate-in-human-urine-samples-by-ion-exclusion-and-ion-exchange-two-dimensional-chromatography-system
#17
Junwei Liu, Zhifen Deng, Zuoyi Zhu, Yong Wang, Guoqing Wang, Yu-An Sun, Yan Zhu
A two-dimensional ion chromatography system was developed for the determination of γ-hydroxybutyrate (GHB) in human urine samples. Ion exclusion chromatography was used in the first dimensional separation for elimination of urine matrices and detection of GHB above 10mgL(-1), ion exchange chromatography was used in the second dimensional separation via column-switching technique for detection of GHB above 0.08mgL(-1). Under the optimized chromatographic conditions, the ion exclusion and ion exchange chromatography separation system exhibited satisfactory repeatability (RSD<3...
October 28, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29119924/deaths-in-the-lesbian-gay-bisexual-and-transgender-united-kingdom-communities-associated-with-ghb-and-precursors
#18
John M Corkery, Barbara Loi, Hugh Claridge, Christine Goodair, Fabrizio Schifano
Background Misuse of gammahydroxybutrate (GHB) and its prodrugs gammabutyrolactone (GBL) and 1,4 butanediol (1,4-BD) has increased greatly since the early 1990s, particularly amongst lesbian, gay, bisexual and transgender (LGBT) individuals in recreational and sexual settings, e.g. 'chemsex'. Objective and method This paper presents an overview of GHB pharmacotoxicology and provides analyses of cases in the LGBT population associated with use of these substances extracted from the UK's National Programme on Substance Abuse Deaths database, to which notification is voluntary...
November 8, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29103326/polymerized-human-placenta-haemoglobin-attenuates-myocardial-injury-and-aortic-endothelial-dysfunction-in-a-rat-model-of-severe-burns
#19
Zhenyu Zhang, Yingyi Zhang, Yan Deng, Shen Li, Wentao Zhou, Chengmin Yang, Xuewen Xu, Tao Li
This study was designed to investigate the effect of polymerized human placenta haemoglobin (PolyPHb) on cardiac dysfunction after severe burns. A total of 60 male Sprague-Dawley rats were randomly divided into 3 groups: Sham, Burn and Burn + PolyPHb groups. Rats were subjected to third-degree burns to 30% of total body surface area and the haemodynamics, cardiac enzyme release and aortic endothelium ultrastructure/function were measured. PolyPHb (0.5 gHb/kg) greatly improved mean arterial pressure, left ventricular developed pressure (LVDP), maximum LVDP increase and decrease rate and reduced left ventricular end-diastolic pressure as compared to the Burn group...
November 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29053743/in-vitro-modeling-of-experimental-succinic-semialdehyde-dehydrogenase-deficiency-ssadhd-using-brain-derived-neural-stem-cells
#20
Kara R Vogel, Garrett R Ainslie, Erwin E Jansen, Gajja S Salomons, Jean-Baptiste Roullet, K Michael Gibson
We explored the utility of neural stem cells (NSCs) as an in vitro model for evaluating preclinical therapeutics in succinic semialdehyde dehydrogenase-deficient (SSADHD) mice. NSCs were obtained from aldh5a1+/+ and aldh5a1-/- mice (aldh5a1 = aldehyde dehydrogenase 5a1 = SSADH). Multiple parameters were evaluated including: (1) production of GHB (γ-hydroxybutyrate), the biochemical hallmark of SSADHD; (2) rescue from cell death with the dual mTOR (mechanistic target of rapamycin) inhibitor, XL-765, an agent previously shown to rescue aldh5a1-/- mice from premature lethality; (3) mitochondrial number, total reactive oxygen species, and mitochondrial superoxide production, all previously documented as abnormal in aldh5a1-/- mice; (4) total ATP levels and ATP consumption; and (5) selected gene expression profiles associated with epilepsy, a prominent feature in both experimental and human SSADHD...
2017: PloS One
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