keyword
MENU ▼
Read by QxMD icon Read
search

GHB

keyword
https://www.readbyqxmd.com/read/29651711/baclofen-to-prevent-relapse-in-gamma-hydroxybutyrate-ghb-dependent-patients-a-multicentre-open-label-non-randomized-controlled-trial
#1
Harmen Beurmanjer, Rama M Kamal, Cor A J de Jong, Boukje A G Dijkstra, Arnt F A Schellekens
BACKGROUND: Gamma-hydroxybutyrate (GHB) dependence is associated with a severe, potentially lethal, withdrawal syndrome and relapse rates as high as 60% within 3 months of detoxification. Baclofen has been shown to decrease self-administration of GHB in mice and reduce relapse in a case series of GHB-dependent patients. Controlled studies on the effectiveness of baclofen to prevent relapse in GHB-dependent patients are lacking. AIM: The aim of this study was to assess effectiveness of baclofen in preventing relapse in GHB-dependent patients...
April 12, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29625796/sexualised-drug-use-in-the-united-kingdom-uk-a-review-of-the-literature
#2
Claire Edmundson, Ellen Heinsbroek, Rachel Glass, Vivian Hope, Hamish Mohammed, Martin White, Monica Desai
BACKGROUND: Sexualised drug use (SDU) refers to the use of drugs in a sexual context. This includes 'Chemsex'- the use of drugs (specifically crystal methamphetamine, GHB/GBL and mephedrone) before or during planned sexual activity to sustain, enhance, disinhibit or facilitate the experience. Here we aimed to synthesise available UK prevalence data for Chemsex, SDU and the use of Chemsex drugs in an undefined context (CDU) in men who have sex with men (MSM). METHODS: Papers published between January 2007 and August 2017 reporting Chemsex, SDU and/or Chemsex drug use (CDU) prevalence in MSM were identified through PubMed...
April 3, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29524621/gamma-hydroxybutyrate-increases-brain-resting-state-functional-connectivity-of-the-salience-network-and-dorsal-nexus-in-humans
#3
Oliver G Bosch, Fabrizio Esposito, Dario Dornbierer, Michael M Havranek, Robin von Rotz, Michael Kometer, Philipp Staempfli, Boris B Quednow, Erich Seifritz
According to the triple network hypothesis the brain is equipped with three core neurocognitive networks: the default mode (DMN), the salience (SN), and the central executive (CEN) network. Moreover, the so called dorsal nexus, has met growing interest as it is a hub region connecting these three networks. Assessment of resting-state functional connectivity (rsFC) of these networks enables the elucidation of drug-induced brain alterations. Gamma-hydroxybutyrate (GHB) is a GHB/GABA-B receptor agonist that induces a paradoxical state of mixed stimulation and sedation at moderate doses, which makes it a valuable tool to investigate neural signatures of subjective drug effects...
March 7, 2018: NeuroImage
https://www.readbyqxmd.com/read/29523484/patterns-of-injecting-and-non-injecting-drug-use-by-sexual-behaviour-in-people-who-inject-drugs-attending-services-in-england-wales-and-northern-ireland-2013-2016
#4
Ellen Heinsbroek, Rachel Glass, Claire Edmundson, Vivian Hope, Monica Desai
BACKGROUND: Higher levels of drug use have been reported in lesbian, gay, bisexual and transgender (LGBT) communities, some of which can be explained by sexualised drug use, including 'chemsex'; the use of drugs before or during planned sexual activity to sustain, enhance, disinhibit or facilitate sex. We explored injecting and non-injecting drug use by sexual behaviour among people who inject drugs (PWID) in England, Wales and Northern Ireland. METHODS: Data were used from an unlinked-anonymous survey of PWID (2013-2016), where participants recruited through services self-completed a questionnaire...
March 6, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29512449/sodium-oxybate-treatment-in-pediatric-type-1-narcolepsy
#5
Monica Moresco, Fabio Pizza, Elena Antelmi, Giuseppe Plazzi
Narcolepsy type 1 (NT1) is a rare chronic neurologic disorder characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hallucinations and disrupted nocturnal sleep, usually with onset during childhood/adolescence. Pediatric NT1 is associated with limitations on children's activities and achievements, especially poor performance at school, difficulty with peers due to disease symptoms and comorbidities including depression, obesity, and precocious puberty. NT1 disease is caused by the selective loss of hypocretin-producing neurons in the lateral hypothalamus, most probably related to an autoimmune pathophysiology...
March 5, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29460030/succinic-semialdehyde-dehydrogenase-deficiency-a-disorder-of-gaba-metabolism-an-update-on-pharmacological-and-enzyme-replacement-therapeutic-strategies
#6
Kara R Vogel, Garrett R Ainslie, Dana C Walters, Alice McConnell, Sameer C Dhamne, Alexander Rotenberg, Jean-Baptiste Roullet, K Michael Gibson
We present an update to the status of research on succinic semialdehyde dehydrogenase (SSADH) deficiency (SSADHD), a rare disorder of GABA metabolism. This is an unusual disorder featuring the accumulation of both GABA and its neuromodulatory analog, gamma-hydroxybutyric acid (GHB), and recent studies have advanced the potential clinical application of NCS-382, a putative GHB receptor antagonist. Animal studies have provided proof-of-concept that enzyme replacement therapy could represent a long-term therapeutic option...
February 19, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29459773/erythrocyte-glutathione-transferase-in-kidney-transplantation-a-probe-for-kidney-detoxification-efficiency
#7
Alessio Bocedi, Annalisa Noce, Valentina Rovella, Giulia Marrone, Giada Cattani, Massimo Iappelli, Paolo De Paolis, Giuseppe Iaria, Daniele Sforza, Mariacarla Gallù, Giuseppe Tisone, Nicola Di Daniele, Giorgio Ricci
Erythrocyte glutathione transferase (e-GST) is overexpressed in case of increased blood toxicity and its level correlates with the kidney disease progression. Thus, it represents a probe of kidney efficiency against circulating toxins. We measured the activity of e-GST in patients with transplant kidney from living and cadaver donors, correlated its level to biochemical parameters of kidney function, and measured the level of oxidized albumin as a probe of oxidative stress using a new simple procedure. Interestingly, the activity of e-GST in transplant patients from cadaver donors (N = 153) is very high (11...
February 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29448841/the-association-of-serum-iron-binding-proteins-and-antioxidant-parameter-levels-in-prelated-macular-degeneration
#8
Emina Čolak, Lepša Žorić, Aleksandra Radosavljević, Svetlana Ignjatović
PURPOSE: Age-related macular degeneration (AMD) is the leading cause of the irreversible central visual loss among the elderly in the developed countries. Iron is considered a potent generator of the oxidative damage whose levels increase with age, potentially exacerbating the age-related diseases. The aim of this study was to assess the serum values of iron, and iron-binding proteins (transferrin, ferritin, and haptoglobin) in patients with AMD along with the parameters of the antioxidant defense: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase, and total antioxidant status (TAS), in order to analyze the possible impact of iron and iron-binding proteins to the development of oxidative stress in AMD patients, and the association of the selected parameters with the AMD...
February 15, 2018: Current Eye Research
https://www.readbyqxmd.com/read/29427917/hiv-treatment-optimism-and-crystal-methamphetamine-use-and-initiation-among-hiv-negative-men-who-have-sex-with-men-in-vancouver-canada-a-longitudinal-analysis
#9
Sean P Colyer, Nathan J Lachowsky, Zishan Cui, Julia Zhu, Heather L Armstrong, Matthew Taylor, Joshua Edward, Gbolahan Olarewaju, Robert S Hogg, Eric A Roth, David M Moore
BACKGROUND: Treatment as Prevention (TasP) leading to increased HIV treatment optimism among men who have sex with men (MSM) has been previously associated with behavioural risk compensation, though not yet via crystal methamphetamine (CM) use. Among HIV-negative MSM in a TasP environment, this study aimed to investigate the prevalence of recent CM use over time, examine the association between HIV treatment optimism and CM use and initiation, and identify correlates of recent CM use and predictors of CM initiation...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29402684/implications-of-survey-labels-and-categorisations-for-understanding-drug-use-in-the-context-of-sex-among-gay-and-bisexual-men-in-melbourne-australia
#10
Kathleen E Ryan, Anna L Wilkinson, Alisa Pedrana, Brendan Quinn, Paul Dietze, Margaret Hellard, Mark Stoové
BACKGROUND: Reliably measuring drug use by gay, bisexual and other men who have sex with men (GBM) in the context of sex can inform sexual health service responses. We report changing drug use patterns among GBM testing for HIV at a community-based service in Melbourne in response to behavioural survey modifications. METHODS: Surveys were completed by GBM prior to all HIV tests. Survey one asked about use of "party drugs for the purpose of sex" and survey two asked about specific drug use (alcohol, amyl nitrate, methamphetamine, cocaine, ecstasy, GHB, Viagra®/Cialis®) before or during sex...
February 2, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29378270/d-ribose-induced-glycoxidative-insult-to-hemoglobin-protein-an-approach-to-spot-its-structural-perturbations
#11
Zeba Siddiqui, Mohd Ishtikhar, Moinuddin, Saheem Ahmad
Glycation of biological macromolecule leads to the establishment of advanced glycation end products (AGEs) having implications in metabolic disorders. d‑ribose appears to be the most reactive among the naturally occurring sugars and contribute significantly to the glycation reactions in vivo, however, no report have been published yet to discuss d‑ribose induced glycation of hemoglobin (Hb). Therefore, the present study was designed to investigate d‑ribose induced glycoxidative damage to Hb protein. Briefly, the commercially available Hb was glycated with d‑ribose for varying time intervals...
January 26, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29374287/-liquid-ecstasy-intoxication-ghb-is-more-prevalent-than-assumed-and-is-potentially-more-harmful
#12
M Richter
No abstract text is available yet for this article.
January 26, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29366411/effects-of-ghb-on-psychomotor-and-driving-performance
#13
Carmela Centola, Arianna Giorgetti, Simona Zaami, Raffaele Giorgetti
BACKGROUND: Gamma-hydroxybutyrate (γ-hydroxybutyrate or GHB) is a physiological compound of mammalians with specific receptors in central nervous system (CNS). Apart from an endogenous production, GHB is also an exogenous molecule found in pharmaceutical as well as in illicit formulations, and it shares the same binding sites and is. Products manufactured and spread in these two fields, whose borders are all but strictly defined and traced, differ for the in-vivo effects and for the potential of abuse...
January 23, 2018: Current Drug Metabolism
https://www.readbyqxmd.com/read/29348108/report-fast-chromatographic-screening-method-for-7-drugs-of-potential-threat-in-drug-facilitated-crimes
#14
Beril Anılanmert, Ibrahim Narın, Ibrahim Aydın, Munevver Acıkkol
In cases where pharmaceuticals and pharmaceutical candidates are involved in drug facilitated crimes (DFC), like organ theft, robbery, rape and suicides, the analysis of drug powders or solution residues found in crime scenes may give idea on what the victims have ingested. An easy and fast simultaneous determination of 7 drugs; GHB (γ-hydroxybutyrate), GBL (γ-butyrolactone), norketamine, ketamine, fenobarbital, fenitoin and thiopental which have the potential to be used in DFC was performed. The method required no sample preparation and has 12 minutes elution time with a good chromatographic separation...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29284546/medical-emergencies-related-to-ethanol-and-illicit-drugs-at-an-annual-nocturnal-indoor-electronic-dance-music-event
#15
Paul Calle, Nora Sundahl, Kristof Maudens, Sarah Mr Wille, Diederik Van Sassenbroeck, Koen De Graeve, Stefan Gogaert, Peter De Paepe, Dieter Devriese, Geert Arno, Peter Blanckaert
Introduction Medical problems are frequently encountered during electronic dance music (EDM) events. Problem There are uncertainties about the frequencies and severity of intoxications with different types of recreational drugs: ethanol, "classical" illicit party drugs, and new psychoactive substances (NPS). METHODS: Statistical data on the medical problems encountered during two editions of an indoor electronic dance event with around 30,000 attendants were retrieved from the Belgian Red Cross (Mechelen, Belgium) database...
February 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29280004/the-drug-of-abuse-gamma-hydroxybutyric-acid-exhibits-tissue-specific-nonlinear-distribution
#16
Melanie A Felmlee, Bridget L Morse, Kristin E Follman, Marilyn E Morris
The drug of abuse γ-hydroxybutyric acid (GHB) demonstrates complex toxicokinetics with dose-dependent metabolic and renal clearance. GHB is a substrate of monocarboxylate transporters (MCTs) which are responsible for the saturable renal reabsorption of GHB. MCT expression is observed in many tissues and therefore may impact the tissue distribution of GHB. The objective of the present study was to evaluate the tissue distribution kinetics of GHB at supratherapeutic doses. GHB (400, 600, and 800 mg/kg iv) or GHB 600 mg/kg plus L-lactate (330 mg/kg iv bolus followed by 121 mg/kg/h infusion) was administered to rats and blood and tissues were collected for up to 330 min post-dose...
December 26, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29260701/-treatment-of-gamma-hydroxybutyrate-withdrawal
#17
Niels August Willer Strand, Tonny Studsgaard Petersen, Lars Martin Nielsen, Soren Boegevig
Gamma-hydroxybutyrate (GHB) is a drug of abuse, for which physical addiction develops quickly. GHB withdrawal can develop into a life-threatening condition and has previously been treated mainly with benzodiazepines. These have not always proven effective, leading to long hospitalizations in intensive care units. Based on successful Dutch treatment results for using GHB to treat GHB withdrawal symptoms, we propose to implement a similar method in Denmark. The method requires an interdisciplinary effort for which The Danish Poison Information Centre should be consulted for expertise...
December 11, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29220733/a-fast-method-for-ghb-gluc-quantitation-in-whole-blood-by-gc-ms-ms-tqd-for-forensic-purposes
#18
Ana S Dias, André L Castro, Paula Melo, Sónia Tarelho, Pedro Domingues, João Miguel Franco
γ-Hydroxybutyric acid (GHB) is an endogenous compound with a historical use, both in licit and illicit terms. Importantly, the post-mortem behavior of GHB has been studied due to the possibility of using this compound as a biomarker for estimating the post-mortem interval (PMI). However, the post-mortem behavior of the recently discovered glucuronated GHB metabolite (GHB-GLUC) has not been studied. Nevertheless, GHB-GLUC may also have potential both to assist in PMI determination and also to increase the window of detection of GHB consumption...
February 20, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29219048/sodium-oxybate-therapy-for-the-treatment-of-alcohol-withdrawal-syndrome-and-the-maintenance-of-alcohol-abstinence
#19
Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra, Gioacchino Calapai
BACKGROUND: Gamma-hydroxybutyrate (GHB or sodium oxybate) is both an exogenous and endogenous molecule with neuromodulator properties. In the United States, GHB is an approved drug for the treatment of narcolepsy and narcolepsy with cataplexy in adults. In some European Union countries, sodium oxybate is applied for the treatment of opioid and alcohol withdrawal. OBJECTIVE: The aim of the present review was to describe the state of art of the pre-clinical research and the clinical evidence related to GHB used alone or in combination with other treatments in alcohol withdrawal syndrome and alcohol abstinence maintenance...
December 7, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29198063/baclofen-in-gamma-hydroxybutyrate-withdrawal-patterns-of-use-and-online-availability
#20
Christopher N Floyd, David M Wood, Paul I Dargan
PURPOSE: Gamma-hydroxybutyrate (GHB) withdrawal is a life-threatening condition that does not always respond to standard treatment with benzodiazepines. Baclofen has potential utility as a pharmacological adjunct and anecdotal reports suggest that it is being used by drug users to self-manage GHB withdrawal symptoms. Here, we investigate current patterns of use and the online availably of baclofen. METHODS: Data triangulation techniques were applied to published scientific literature and publicly accessible Internet resources (grey literature) to assess the use of baclofen in GHB withdrawal...
March 2018: European Journal of Clinical Pharmacology
keyword
keyword
73728
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"