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Hyperleukocytosis

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https://www.readbyqxmd.com/read/29861566/renal-vein-thrombosis-as-presentation-of-non-m3-acute-myeloid-leukemia-in-an-adult-patient
#1
S K Sureka, P Yadav, P Kumar, A Srivastava
A 46-year-old male presented with left flank pain and was found to have left nephromegaly with renal vein and inferior vena cava (IVC) thrombus. On hematological evaluation, he had leukocytosis and thrombocytopenia. Further evaluation revealed acute myeloid leukemia (AML). Following initial cytoreductive therapy and supportive care for hyperleukocytosis, he underwent left simple nephrectomy with IVC thrombectomy. Postoperatively, he developed massive thrombosis of infrahepatic IVC with renal failure. Renal venous thrombosis as a rare presentation of AML in adults with leukemic hyperleukocytosis has not been reported...
March 2018: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/29845392/clinical-pharmacokinetics-and-safety-profile-of-single-agent-arsenic-trioxide-by-continuous-slow-rate-infusion-in-patients-with-newly-diagnosed-acute-promyelocytic-leukemia
#2
Chunlu Gao, Shuang Hu, Meihua Guo, Xin Hai, Jin Zhou
PURPOSE: This study evaluated pharmacokinetics (PK) and safety profiles of single agent arsenic trioxide (ATO, As2 O3 ) administrated as continuous slow-rate infusion in patients with newly diagnosed acute promyelocytic leukemia. PATIENTS AND METHODS: Patients received 0.16 mg/kg ATO per day. ATO was given for 40 min infusion on the first day followed by 18-20 h daily at a very slow rate with infusion speed of 8 drips/min. During the first week, plasma samples were collected immediately before next administration on each day, and 0...
May 29, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29724902/phase-i-trial-of-plerixafor-combined-with-decitabine-in-newly-diagnosed-older-patients-with-acute-myeloid-leukemia
#3
Gail J Roboz, Ellen K Ritchie, Yulia Dault, Linda Lam, Danielle C Marshall, Nicole M Cruz, Hsiao-Ting C Hsu, Duane C Hassane, Paul J Christos, Cindy Ippoliti, Joseph M Scandura, Monica L Guzman
Acute myeloid leukemia carries a dismal prognosis in older patients. The objective of this study was to investigate the safety and efficacy of decitabine combined with the CXCR4 antagonist plerixafor in newly diagnosed older patients with acute myeloid leukemia and to evaluate the effects of plerixafor on leukemia stem cells. Patients were treated with monthly cycles of decitabine 20 mg/m2 days 1-10 and escalating doses of plerixafor (320-810 mcg/kg) days 1-5. Sixty-nine patients were treated, with overall response rate 43%...
May 3, 2018: Haematologica
https://www.readbyqxmd.com/read/29703037/fatal-malignant-pertussis-with-hyperleukocytosis-in-a-chinese-infant-a-case-report-and-literature-review
#4
REVIEW
Shu-Feng Tian, Hong-Mei Wang, Ji-Kui Deng
RATIONALE: Pertussis has re-emerged on a global scale and is an ongoing public health problem, even in countries with high rates of vaccination. Hyperleukocytosis [white blood cell (WBC) count >100 × 10/L] is a rare complication that strongly predicts mortality in cases of severe pertussis. PATIENT CONCERNS: We report a case of severe pertussis in an infant who initially presented with persistent cyanotic cough, tachypnea, and grunting. The infant's condition deteriorated rapidly, and she was transferred to the pediatric intensive care unit (PICU) during her third hour of hospitalization...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29687365/a-diagnostic-dilemma-in-the-emergency-room-intracranial-hemorrhages-in-acute-myeloblastic-leukemia-with-hyperleukocytosis
#5
Mustafa Kemal Demir
No abstract text is available yet for this article.
April 23, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29676946/unclassifiable-b-cell-lymphoma-with-symptomatic-hyperleukocytosis-managed-with-leukapheresis
#6
Lakshmi Manogna Chintalacheruvu, Jayadev Manikkam Umakanthan, Teddi Hernandez, Bryan Teruya, Apar Kishor Ganti
No abstract text is available yet for this article.
May 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29667455/beliefs-and-practice-patterns-in-hyperleukocytosis-management-in-acute-myeloid-leukemia-a-large-u-s-web-based-survey
#7
Maximilian Stahl, Alexander Pine, Jeanne E Hendrickson, Mark R Litzow, Selina M Luger, Richard M Stone, Harry P Erba, Tae Kon Kim, Mikkael A Sekeres, David P Steensma, Rami S Komrokji, Steven D Gore, Amer M Zeidan
No abstract text is available yet for this article.
April 18, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29662604/fr%C3%A3-quence-et-d%C3%A3-terminants-de-la-d%C3%A3-nutrition-post-op%C3%A3-ratoire-en-chirurgie-visc%C3%A3-rale-au-centre-national-hospitalier-et-universitaire-koutoucou-hubert-maga-cotonou-frequency-and-determinants-of-post-operative-undernutrition-in-patients-undergoing-visceral
#8
Adébayo Cossi Alassani, Adrien Montcho Hodonou, Albert Comlan Dovonou, Gaspard Dansou Gbessi, Séraphin Ahoui, Francis Moïse Dossou, Delphin Kouassi Mêhinto
This study aims to determine the frequency and identify the factors associated with undernutrition among patients undergoing visceral surgery in 2014. We conducted a cross-sectional, descriptive and analytical study over the period September 11, 2014-December 11, 2014. The study population comprised patients who had undergone visceral surgery at the National University Hospital Centre Koutoucou Hubert MAGA, Cotonou. Undernutrition is defined as a body mass index less than 18.5 kg/m2 . A total of 90 patients were included in the study, 57,78% (52 patients) were male...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29624746/hyperleukocytosis-is-associated-with-distinct-genetic-alterations-and-is-an-independent-poor-risk-factor-in-de-novo-acute-myeloid-leukemia-patients
#9
Feng-Ming Tien, Hsin-An Hou, Cheng-Hong Tsai, Jih-Luh Tang, Chien-Yuan Chen, Yuan-Yeh Kuo, Chi-Cheng Li, Chien-Ting Lin, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Shang-Ju Wu, Woei Tsay, Mei-Hsuan Tseng, Ming-Chih Liu, Chia-Wen Liu, Liang-In Lin, Wen-Chien Chou, Hwei-Fang Tien
OBJECTIVES: Acute myeloid leukemia (AML) with hyperleukocytosis (HL) is intuitively thought as a unique group with dismal prognosis. However, comprehensive studies regarding the genetic landscape and clinical outcome in this group of patients are limited. METHODS: A total of 693 newly diagnosed de novo non-M3 AML patients were consecutively enrolled. We compared relevant mutations in 20 genes between AML patients with or without HL and exposed their prognostic implications...
April 6, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29616647/epidemiology-of-malignant-hemopathies-recorded-in-hospitals-in-cameroon
#10
P T Moueleu Ngalagou, E Ngouadjeu Dongho Tsakeu, F Ngo Sack, E C Eboumbou Moukoko, Y Konn Jolly, H Luma
Data about malignant blood diseases are sparse in Cameroon. Their epidemiology was studied in patients at the General Hospital of Douala (GHD) and the Yaoundé Central Hospital (CHY) from 2004 through 2014. The variables we studied were social and demographic (age, sex, occupation, marital status), clinical (reasons for consultation, clinical signs, year of diagnosis), and biological (blood count, myelogram and blood smear, immunophenotyping, biopsy, and cytogenetics). In all, 4409 files were reviewed and 454 cases identified, documented and confirmed (248 in GHD and 206 in CHY)...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29477941/the-management-of-hyperleukocytosis-in-2017-do-we-still-need-leukapheresis
#11
REVIEW
Serdal Korkmaz
Hyperleukocytosis is defined as a white blood cell count greater than 100.000/μL in patients affected by acute or chronic leukemias. Hyperleukocytosis is more common in acute leukemias than in chronic leukemias. Risk factors include younger age, acute myeloid leukemia, the microgranular variant of acute promyelocytic leukemia, acute lymphoblastic leukemia and some cytogenetic abnormalities. Although it can affect any organ system, symptoms usually arise from involvement of the cerebral, pulmonary and renal microvasculature...
February 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29475404/dose-related-mucositis-with-hydroxyurea-for-cytoreduction-in-acute-myeloid-leukemia
#12
Morgan L Trepte, Jessica J Auten, Stephen M Clark, Hendrik W van Deventer
Hyperleukocytosis occurs in 15-20% of all newly diagnosed acute myeloid leukemia patients and requires emergent treatment with leukapheresis or hydroxyurea when accompanied by signs or symptoms of leukostasis. Currently, there is no standardized hydroxyurea dosing strategy, although usual dosing ranges from 50 to 150 mg/kg/day, and prescribing patterns vary significantly among oncologists and institutions. In addition to other hematologic and dermatologic toxicities, the use of hydroxyurea may be associated with significant mucositis and mucositis-related pain...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29443409/cellular-collection-by-apheresis
#13
REVIEW
Anand Padmanabhan
Cellular collection is an important and increasingly used apheresis procedure. These collections are performed by leukocytapheresis, a procedure involving the removal of a patient's or donor's white blood cells, and are used to collect hematopoietic progenitor cells, specific cell populations (such as T-lymphocytes), and granulocytes. Hematopoietic progenitor cell apheresis and T-lymphocyte collection are performed by procedures that enrich for mononuclear cells. Hematopoietic progenitor cells are used for autologous and allogeneic hematopoietic stem cell transplantation, whereas T-cell collection is being used increasingly in novel cellular therapy approaches and for donor lymphocyte infusions to induce graft-versus-leukemia effect...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29438972/interference-of-hyperleukocytosis-in-red-blood-cell-count
#14
Rémy Favre, Alexis Genthon
No abstract text is available yet for this article.
February 8, 2018: Blood
https://www.readbyqxmd.com/read/29399859/hyperleukocytosis-in-infant-acute-leukemia-a-role-for-manual-exchange-transfusion-for-leukoreduction
#15
Daniel V Runco, Cassandra D Josephson, Sunil S Raikar, Kelly C Goldsmith, Glen Lew, Melinda Pauly, Ross M Fasano
BACKGROUND: Hyperleukocytosis is a serious, life-threatening complication of pediatric acute leukemia that can cause neurologic injury, pulmonary leukostasis, metabolic derangements, and coagulopathy. Acute leukemia has the highest risk of mortality and morbidity at presentation when associated with hyperleukocytosis. Infant leukemia presents unique challenges and treatment considerations due to the disease itself and size and overall health of the patient. While medical management of hyperleukocytosis in older patients with acute leukemia has been described, including cytoreductive procedures with automated leukapheresis (AL) or manual whole blood (WB) exchange transfusion, very little data exist for standardized management of hyperleukocytosis in infant leukemia patients...
May 2018: Transfusion
https://www.readbyqxmd.com/read/29332446/lung-cancer-complicated-with-asymptomatic-pulmonary-embolism-clinical-analysis-of-84-patients
#16
Guangsheng Li, Yuechuan Li, Shuping Ma
BACKGROUND AND OBJECTIVE: Pulmonary embolism is potentially life-threatening in patients with lung cancer, but the clinical studies on patients with lung cancer having asymptomatic pulmonary embolism were barely reported. METHODS: Clinical data of patients with lung cancer were obtained from the Department of Respiratory and Critical Care Medicine of Tianjin Chest Hospital during July 2012 and June 2015 and were reviewed retrospectively. A total of 28 patients with lung cancer having pulmonary embolism (LP group) were enrolled, and another 56 cases with lung cancer alone (LC group) were enrolled as controls...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29303660/acute-megakaryoblastic-leukemia-excluding-down-syndrome-remains-an-acute-myeloid-subgroup-with-inferior-outcome-in-the-french-elam02-trial
#17
Anne-Charlotte Teyssier, Hélène Lapillonne, Marlene Pasquet, Paola Ballerini, André Baruchel, Stephane Ducassou, Odile Fenneteau, Arnaud Petit, Wendy Cuccuini, Christine Ragu, Claude Preudhomme, Thomas Mercher, Nicolas Sirvent, Guy Leverger
We report the outcome of 27 children with de novo acute megakaryoblastic leukemia (AMKL) (excluding Down syndrome) enrolled in the French multicenter prospective study ELAM02 (2005-2011). There was no difference in gender, initial leukocyte count, CNS involvement, and complete remission rate (88.9%), as compared to other acute myeloid leukemia (AML) subtypes. AMKL patients had a significantly poorer outcome (5-year overall survival 54% [CI 95% 33%-71%] than children with other AML subtypes (5-year overall survival 73% [CI 95% 68%-77%] p = 0...
November 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29286559/high-incidence-of-acute-kidney-injury-during-chemotherapy-for-childhood-acute-myeloid-leukemia
#18
Liezl Du Plessis, Shahrad Rod Rassekh, Cherry Mammen
BACKGROUND/OBJECTIVES: Childhood acute myeloid leukemia (AML) is a rare and heterogeneous disease. Pediatric data on the epidemiology of acute kidney injury (AKI) in AML are limited. We report on the incidence of AKI in childhood AML and the risk factors associated with AKI episodes. METHODS: A retrospective cohort of 53 patients (≤18 years), with de novo AML, receiving chemotherapy over a 10-year period. All serum creatinine (SCr) levels during therapy-related hospitalizations were assessed to stage AKI episodes as per Kidney Disease: Improving Global Outcomes criteria...
April 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29233561/real-and-spurious-hypoxemia-in-a-patient-with-extreme-hyperleukocytosis
#19
M Angulo, D Machado, L Larrosa, A Biestro
No abstract text is available yet for this article.
December 9, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29230832/management-of-chronic-myeloid-leukemia-in-the-setting-of-pregnancy-when-is-leukocytapheresis-appropriate-a-case-report-and-review-of-the-literature
#20
Elizabeth M Staley, Sierra C Simmons, Alexander Z Feldman, Robin G Lorenz, Marisa B Marques, Lance A Williams, X Long Zheng, Huy P Pham
BACKGROUND: Chronic myeloid leukemia (CML) is a common hematologic malignancy; however, its occurrence during pregnancy is unusual due to its low prevalence in females of childbearing age. There are conflicting reports of how to best manage CML in pregnancy, particularly in the setting of leukocytosis. HEMAPHERESIS: A 30-year-old female was diagnosed with CML at 18 weeks' estimated gestational age. On initial presentation she reported fatigue, night sweats, and early satiety, and was found to have a white blood cell (WBC) count of 69...
February 2018: Transfusion
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