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cryo analgesia

Antoine Koehl, Hongli Hu, Shoji Maeda, Yan Zhang, Qianhui Qu, Joseph M Paggi, Naomi R Latorraca, Daniel Hilger, Roger Dawson, Hugues Matile, Gebhard F X Schertler, Sebastien Granier, William I Weis, Ron O Dror, Aashish Manglik, Georgios Skiniotis, Brian K Kobilka
The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most clinically and recreationally used opioids. The induced positive effects of analgesia and euphoria are mediated by μOR signalling through the adenylyl cyclase-inhibiting heterotrimeric G protein Gi . Here we present the 3.5 Å resolution cryo-electron microscopy structure of the μOR bound to the agonist peptide DAMGO and nucleotide-free Gi . DAMGO occupies the morphinan ligand pocket, with its N terminus interacting with conserved receptor residues and its C terminus engaging regions important for opioid-ligand selectivity...
June 13, 2018: Nature
A W van Eps, C C Pollitt, C Underwood, C E Medina-Torres, W A Goodwin, J K Belknap
REASONS FOR PERFORMING STUDY: Prophylactic digital hypothermia reduces the severity of acute laminitis experimentally but there is no evidence for its efficacy as a treatment once lameness has already developed. OBJECTIVES: To investigate the therapeutic effects of digital hypothermia, applied after the onset of lameness, in an experimental acute laminitis model. STUDY DESIGN: Randomised, controlled (within subject), blinded, experimental trial...
September 2014: Equine Veterinary Journal
Evangelos Sepsas, Panagiotis Misthos, Maria Anagnostopulu, Olga Toparlaki, Gregorios Voyagis, Stamatios Kakaris
OBJECTIVES: Patients undergoing thoracotomy were studied to compare the effects of cryoanalgesia, combined with intravenous patient-controlled analgesia (IVPCA), against IVPCA alone during the four days following surgery. METHODS: Fifty patients were randomized into two groups: an IVPCA group (n = 25) and an IVPCA-cryo group (n = 25). Subjective pain intensity was assessed on a verbal analogue scale at rest and during coughing. The intensity and the incidence of post-thoracotomy pain, numbness, epigastric distension and/or back pain, the analgesic requirements, as well as the blood gas values and respiratory function tests were evaluated up to the second postoperative (postop) month...
June 2013: Interactive Cardiovascular and Thoracic Surgery
Abdolhadi Jahanshahi, Esmail Mashhadizadeh, Mohammad-Hossein Sarmast
UNLABELLED: Hemorrhoid is protrusion of plexus or blood vessels in the anal canal. The hemorrhoid may cause symptoms that are: bleeding, pain, prolaps, itching, soilage of feces, and psychologic discomfort. There are many methods for treatment of hemorrhoid like, medical therapy, cryo-therapy, rubber band ligation, sclerotherapy, laser, and surgery. All methods have some complication in postoperative period and recurrence. THE AIM OF THE STUDY: Was to evaluate Diode laser for treatment of hemorrhoid...
July 2012: Polski Przeglad Chirurgiczny
A S Thornton, P Janse, M Alings, M F Scholten, J M Mekel, M Miltenburg, E Jessurun, L Jordaens
OBJECTIVES: To compare the acute success and short-term follow-up of ablation of atrial flutter using 8 mm tip radiofrequency (RF) and cryocatheters. METHODS: Sixty-two patients with atrial flutter were randomized to RF or cryocatheter (cryo) ablation. Right atrial angiography was performed to assess the isthmus. End point was bidirectional isthmus block on multiple criteria. A pain score was used and the analgesics were recorded. Patients were followed for at least 3 months...
April 2008: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Hui Ju, Yi Feng, Ba-Xian Yang, Jun Wang
Epidural analgesia is regarded as the gold method for controlling post-thoracotomy pain. Intercostal nerve cryoanalgesia can also produce satisfactory analgesic effects, but is suspected to increase the incidence of chronic pain. However, randomized controlled trials comparing these two methods for post-thoracotomy acute pain analgesic effects and chronic pain incidents have not been conducted previously. We studied 107 adult patients, allocated randomly to thoracic epidural bupivacaine and morphine or intercostal nerve cryoanalgesia...
April 2008: European Journal of Pain: EJP
S Goel, B Chang, K Bhan, N El-Hindy, S Kolli
INTRODUCTION: Lid surgery under local anaesthetic is commonplace in ophthalmic practise. The most distressing part of the surgery for the patient is often the injection of local anaesthetic into the sensitive lid skin. Various methods like pre-injection warming of the anaesthetic agent, buffering pH levels, varying agents used, and using thinner gauge needles have been tried to reduce pain levels. Cooling of tissue is known to have anaesthetic properties and has been proposed as a substitute to injection of local anaesthetic in certain surgical procedures...
June 2006: Orbit
Nicolas H Zech, Paulo Netzbandt, Herbert Zech
OBJECTIVE: To report a case of severe ovarian hyperstimulation syndrome (OHSS) after inadvertent GnRH long protocol/hMG stimulation in a pre-existing early pregnancy. DESIGN: Case report. SETTING: Private infertility clinic. PATIENT(S): A 28-year-old woman who conceived spontaneously following IVF and cryo-embryo transfer (cryo-ET). INTERVENTION(S): IVF/intracytoplasmic sperm injection (ICSI), cryo-ET, analgesia, and forced diuresis...
December 2005: Fertility and Sterility
Mi Sook Gwak, Mikyung Yang, Tae Soo Hahm, Hyun Sung Cho, Chung Hwan Cho, Jae Gyok Song
Fifty patients undergoing thoracotomy was studied to compare the effects of cryoanalgesia combined with intravenous continuous analgesia (IVCA). Patients were randomized into two groups: IVCA group and IVCA-cryo group. Subjective pain intensity was assessed on a visual analogue scale at rest (VAS-R) and during movement (VAS-M). Analgesic requirements were evaluated over the 7 days following surgery. Forced vital capacity (FVC) and forced expiratory volume in 1 sec (FEV1) were measured before operation, on the 2nd and 7th postoperative days (POD)...
February 2004: Journal of Korean Medical Science
No abstract text is available yet for this article.
November 1963: Minerva Anestesiologica
F Zhao, Y Tian, D Liu
OBJECTIVE: To alleviate and prevent postthoracotomy severe chest pain. METHODS: In dogs, intercostal nerves were freezed at -50 degrees C at different times. Pathological changes and repair process of the nerves were observed while identifying the best freezing time that could be used clinically. Prospective double-blind randomized trial in 200 patients who had undergone thoracotomy was carried out from January 1996 to June, 2000. Cryoanalgesia(Cryo group) and control group consisted of 100 patients...
November 2001: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
C E Gibbons, M C Solan, D M Ricketts, M Patterson
Sixty patients undergoing total knee replacement were randomized to receive either a cold compression dressing (Cryo/Cuff, Aircast, UK) or a modified Robert Jones bandage immediately after surgery. The cold compression dressing was used for a minimum of 6 h per day throughout the hospital stay, and the modified Robert Jones bandage remained in place for 48 h from the time of operation. The 2 groups of patients were compared during their hospital stay for blood loss, range of movement, pain scores and need for analgesia...
2001: International Orthopaedics
N Moorjani, F Zhao, Y Tian, C Liang, J Kaluba, M O Maiwand
OBJECTIVE: The choice of analgesia in the management of post-thoracotomy pain remains controversial. Although several alternative forms of post-thoracotomy analgesia exist, all have their disadvantages. Cryoanalgesia, localized freezing of intercostal nerves, has been reported to have variable effectiveness and an incidence of long-term cutaneous sensory changes. We carried out an animal study to assess the reversibility of histological changes induced by cryoanalgesia and a prospective randomized trial to compare the effectiveness of cryoanalgesia with conventional analgesia (parenteral opiates)...
September 2001: European Journal of Cardio-thoracic Surgery
M Mehta, C B Parry
Mechanical back pain is a common disability often associated with the facet joint syndrome. Treatment is based on early, adequate pain relief with simple techniques of regional analgesia. In a few cases this is not enough and more sophisticated methods, such as radiofrequency denervation, cryo-analgesia and possibly intrathecal midazolam, are necessary. However, the main thrust of our approach is to treat the underlying structural disorder with strengthening of the back muscles and correction of postural abnormalities responsible for the mechanical back pain...
January 1994: Disability and Rehabilitation
Q Wang, D Hu, L Ru, X Guan
UNLABELLED: 31 adult rats were divided into 4 groups: 1) Electroacupuncture group; 2) Capsaicin group (capsaicin was applied one the left sciatic nerve, the night on of the same body was used with vehicle as control); 3) Capaicin combined with electroacupuncture group; 4) Control group. Pain thresholds, both basal and after treatment were determined. Successive cryo-sections of DRG were cut and the neighbouring section of the same group were performed for AChE and FRAP examination. RESULTS: Little disparity in basal pain threshold was found among the four groups...
1993: Zhen Ci Yan Jiu, Acupuncture Research
L Zhou, P Kambin, K F Casey, F J Bonner, E O'Brien, Z Shao, S Ou
The sciatic nerves of rabbits were frozen at different temperatures (-20 degrees C, -60 degrees C, -100 degrees C, -140 degrees C, and -180 degrees C). The morphology and function of the frozen nerves were examined with light microscopy (hematoxylin and eosinophilin stain and a histochemical thiocholine method) and electron microscopy. The function of the nerve after freezing was assessed using short latency somatosensory evoked potentials, sensory conduction velocity, and electromyogram at various intervals after freezing...
August 1995: Neurological Research
R Milleret
Fifty limb salvages were attempted by using phenol sympathectomy combined with cryo-analgesia of foot nerves in patients with distal lesions. Cryo-analgesia does not interfere with walking and exercising and avoids oedema. Results were gratifying in patients with rest pain, and no gangrenous involvement: 80% of salvages. Very old patients (over 90 years) experienced satisfactory results in 60% of the cases. Even when a reconstructive procedure had failed previously, we achieved a 25% limb salvage rate. Thus cryo-analgesia under local anesthesia appears as a useful therapy for elderly patients with distal arterial disease...
1983: Journal des Maladies Vasculaires
J D Gough, A B Williams, R S Vaughan, J F Khalil, E G Butchart
This is a comparative study of two methods to relieve postoperative thoracotomy pain. Continuous thoracic epidural infusion of fentanyl produced superior analgesia when compared with cryo-analgesia of the relevant thoracic nerves. Linear analogue pain scores were consistently lower in the epidural group reaching significance (p less than 0.05) at 32 and 40 hours after operation. All 36 patients in the cryo-analgesia group required additional analgesia, while 12 out of the 32 patients in the epidural group did not...
September 1988: Anaesthesia
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