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https://www.readbyqxmd.com/read/28098828/development-of-a-topical-resveratrol-formulation-for-commercial-applications-using-dendrimer-nanotechnology
#1
Tyler Pentek, Eric Newenhouse, Brennin O'Brien, Abhay Singh Chauhan
Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However, resveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare a resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents and oils that could be harmful to the human body and the environment. Hence, we propose the use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol. A dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement, stability in solution and cream dosage forms...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28097937/an-assembly-type-master-slave-catheter-and-guidewire-driving-system-for-vascular-intervention
#2
Hyo-Jeong Cha, Byung-Ju Yi, Jong Yun Won
Current vascular intervention inevitably exposes a large amount of X-ray to both an operator and a patient during the procedure. The purpose of this study is to propose a new catheter driving system which assists the operator in aspects of less X-ray exposure and convenient user interface. For this, an assembly-type 4-degree-of-freedom master-slave system was designed and tested to verify the efficiency. First, current vascular intervention procedures are analyzed to develop a new robotic procedure that enables us to use conventional vascular intervention devices such as catheter and guidewire which are commercially available in the market...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28097082/a-review-of-colorectal-cancer-detection-modalities-stool-dna-and-fecal-immunochemistry-testing-in-adults-over-the-age-of-50
#3
REVIEW
Tyler Janz, Karen Lu, Michael R Povlow, Brittany Urso
Colorectal cancer (CRC) is the third leading cause of cancer death in the United States. Recently, more focus has been placed on developing effective screening tools to detect the presence of both precancerous and cancerous lesions present in the colon and rectum. Colonoscopy has been well established as the gold standard of the colon and rectal cancer screening. However, not all patients are willing to undergo a colonoscopy due to the procedure's invasive nature. Non-invasive screening methods have been developed to appeal to patients who refuse colonoscopy...
December 16, 2016: Curēus
https://www.readbyqxmd.com/read/28097060/why-choose-random-forest-to-predict-rare-species-distribution-with-few-samples-in-large-undersampled-areas-three-asian-crane-species-models-provide-supporting-evidence
#4
Chunrong Mi, Falk Huettmann, Yumin Guo, Xuesong Han, Lijia Wen
Species distribution models (SDMs) have become an essential tool in ecology, biogeography, evolution and, more recently, in conservation biology. How to generalize species distributions in large undersampled areas, especially with few samples, is a fundamental issue of SDMs. In order to explore this issue, we used the best available presence records for the Hooded Crane (Grus monacha, n = 33), White-naped Crane (Grus vipio, n = 40), and Black-necked Crane (Grus nigricollis, n = 75) in China as three case studies, employing four powerful and commonly used machine learning algorithms to map the breeding distributions of the three species: TreeNet (Stochastic Gradient Boosting, Boosted Regression Tree Model), Random Forest, CART (Classification and Regression Tree) and Maxent (Maximum Entropy Models)...
2017: PeerJ
https://www.readbyqxmd.com/read/28095915/development-and-validation-of-seer-seeking-engaging-with-and-evaluating-research-a-measure-of-policymakers-capacity-to-engage-with-and-use-research
#5
Sue E Brennan, Joanne E McKenzie, Tari Turner, Sally Redman, Steve Makkar, Anna Williamson, Abby Haynes, Sally E Green
BACKGROUND: Capacity building strategies are widely used to increase the use of research in policy development. However, a lack of well-validated measures for policy contexts has hampered efforts to identify priorities for capacity building and to evaluate the impact of strategies. We aimed to address this gap by developing SEER (Seeking, Engaging with and Evaluating Research), a self-report measure of individual policymakers' capacity to engage with and use research. METHODS: We used the SPIRIT Action Framework to identify pertinent domains and guide development of items for measuring each domain...
January 17, 2017: Health Research Policy and Systems
https://www.readbyqxmd.com/read/28095904/evaluation-of-the-tsima-community-mobilization-intervention-to-improve-engagement-in-hiv-testing-and-care-in-south-africa-study-protocol-for-a-cluster-randomized-trial
#6
Sheri A Lippman, Audrey Pettifor, Dumisani Rebombo, Aimée Julien, Ryan G Wagner, Mi-Suk Kang Dufour, Chodziwadziwa Whiteson Kabudula, Torsten B Neilands, Rhian Twine, Ann Gottert, F Xavier Gómez-Olivé, Stephen M Tollman, Ian Sanne, Dean Peacock, Kathleen Kahn
BACKGROUND: HIV transmission can be decreased substantially by reducing the burden of undiagnosed HIV infection and expanding early and consistent use of antiretroviral therapy (ART). Treatment as prevention (TasP) has been proposed as key to ending the HIV epidemic. To activate TasP in high prevalence countries, like South Africa, communities must be motivated to know their status, engage in care, and remain in care. Community mobilization (CM) has the potential to significantly increase uptake testing, linkage to and retention in care by addressing the primary social barriers to engagement with HIV care-including poor understanding of HIV care; fear and stigma associated with infection, clinic attendance and disclosure; lack of social support; and gender norms that deter men from accessing care...
January 17, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28095875/assessment-of-synthetic-floral-based-attractants-and-sugar-baits-to-capture-male-and-female-aedes-aegypti-diptera-culicidae
#7
Kara Fikrig, Brian J Johnson, Durland Fish, Scott A Ritchie
BACKGROUND: The viruses transmitted by Aedes aegypti, including dengue and Zika viruses, are rapidly expanding in geographic range and as a threat to public health. In response, control programs are increasingly turning to the use of sterile insect techniques resulting in a need to trap male Ae. aegypti to monitor the efficacy of the intervention. However, there is a lack of effective and cheap methods for trapping males. Thus, we attempted to exploit the physiological need to obtain energy from sugar feeding in order to passively capture male and female Ae...
January 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28095490/costs-and-tradeoffs-of-resistance-and-tolerance-to-belowground-herbivory-in-potato
#8
Etzel Garrido, Maria Fernanda Díaz, Hugo Bernal, Carlos Eduardo Ñustez, Jennifer Thaler, Georg Jander, Katja Poveda
The success of sustainable crop production depends on our ability to select or create varieties that can allocate resources to both growth and defence. However, breeding efforts have emphasized increases in yields but have partially neglected defence traits against pests. Estimating the costs of multiple defences against tuber herbivores and the tradeoffs among them, as well as understanding the relationship between yield and multiple defences is still unknown but relevant to both basic and applied ecology...
2017: PloS One
https://www.readbyqxmd.com/read/28095414/mosquito-disseminated-insecticide-for-citywide-vector-control-and-its-potential-to-block-arbovirus-epidemics-entomological-observations-and-modeling-results-from-amazonian-brazil
#9
Fernando Abad-Franch, Elvira Zamora-Perea, Sérgio L B Luz
BACKGROUND: Mosquito-borne viruses threaten public health worldwide. When the ratio of competent vectors to susceptible humans is low enough, the virus's basic reproductive number (R0) falls below 1.0 (each case generating, on average, <1.0 additional case) and the infection fades out from the population. Conventional mosquito control tactics, however, seldom yield R0 < 1.0. A promising alternative uses mosquitoes to disseminate a potent growth-regulator larvicide, pyriproxyfen (PPF), to aquatic larval habitats; this kills most mosquito juveniles and substantially reduces adult mosquito emergence...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28095068/impact-of-telepharmacy-services-as-a-way-to-increase-access-to-asthma-care
#10
Wendy Brown, David Scott, Daniel Friesner, Tara Schmitz
OBJECTIVE: To demonstrate that real-time, telepharmacy-based asthma educational services are feasible and support the efforts of local primary care prescribers to improve patient outcomes. METHODS: The lead investigator [a pharmacist, physician assistant and certified asthma educator] identified an independent community pharmacy with telehealth capabilities in a rural area with a high prevalence of asthma. Working with the pharmacy, an asthma education program was developed based on the National Asthma Education and Prevention Program guidelines...
January 17, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28094534/in-vitro-assessment-of-skin-irritation-potential-of-surfactant-based-formulations-by-using-a-3-d-skin-reconstructed-tissue-model-and-cytokine-response
#11
Russel M Walters, Lisa Gandolfi, M Catherine Mack, Michael Fevola, Katharine Martin, Mathew T Hamilton, Allison Hilberer, Nicole Barnes, Nathan Wilt, Jennifer R Nash, Hans A Raabe, Gertrude-Emilia Costin
The personal care industry is focused on developing safe, more efficacious, and increasingly milder products, that are routinely undergoing preclinical and clinical testing before becoming available for consumer use on skin. In vitro systems based on skin reconstructed equivalents are now established for the preclinical assessment of product irritation potential and as alternative testing methods to the classic Draize rabbit skin irritation test. We have used the 3-D EpiDerm™ model system to evaluate tissue viability and primary cytokine interleukin-1α release as a way to evaluate the potential dermal irritation of 224 non-ionic, amphoteric and/or anionic surfactant-containing formulations, or individual raw materials...
December 2016: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28093817/cryptic-inbreeding-depression-in-a-growing-population-of-a-long-lived-species
#12
Helen R Taylor, Rogan M Colbourne, Hugh A Robertson, Nicola J Nelson, Fred W Allendorf, Kristina M Ramstad
Genetic effects are often overlooked in endangered species monitoring, and populations showing positive growth are often assumed to be secure. However, the continued reproductive success of a few individuals may mask issues such as inbreeding depression, especially in long-lived species. Here, we test for inbreeding depression in little spotted kiwi (Apteryx owenii) by comparing a population founded with two birds to one founded with 40 birds, both from the same source population and both showing positive population growth...
January 17, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28093430/development-and-validation-of-a-prediction-model-for-gestational-hypertension-in-a-ghanaian-cohort
#13
Edward Antwi, Rolf H H Groenwold, Joyce L Browne, Arie Franx, Irene A Agyepong, Kwadwo A Koram, Kerstin Klipstein-Grobusch, Diederick E Grobbee
OBJECTIVE: To develop and validate a prediction model for identifying women at increased risk of developing gestational hypertension (GH) in Ghana. DESIGN: A prospective study. We used frequencies for descriptive analysis, χ(2) test for associations and logistic regression to derive the prediction model. Discrimination was estimated by the c-statistic. Calibration was assessed by calibration plot of actual versus predicted probability. SETTING: Primary care antenatal clinics in Ghana...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28092941/21st-century-cell-culture-for-21st-century-toxicology
#14
David Pamies, Thomas Hartung
There is no good science in bad models. Cell culture is especially prone to artifacts. A number of novel cell culture technologies have become more broadly available in the 21st century, which allow overcoming limitations of traditional culture and are more physiologically relevant. These include the use of stem-cell derived human cells, cocultures of different cell types, scaffolds and extracellular matrices, perfusion platforms (such as microfluidics), 3D culture, organ-on-chip technologies, tissue architecture, and organ functionality...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28092541/quality-assessment-of-sharpened-images-challenges-methodology-and-objective-metrics
#15
Lukas Krasula, Patrick Le Callet, Karel Fliegel, Milos Klima
Most of the effort in image quality assessment (QA) has been so far dedicated to the degradation of the image. However, there are also many algorithms in the image processing chain that can enhance the quality of an input image. These include procedures for contrast enhancement, deblurring, sharpening, up-sampling, denoising, transfer function compensation, etc. In this work, possible strategies for the quality assessment of sharpened images are investigated. This task is not trivial because the sharpening techniques can increase the perceived quality, as well as introduce artifacts leading to the quality drop (over-sharpening)...
January 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28092071/explaining-the-immigrant-health-advantage-self-selection-and-protection-in-health-related-factors-among-five-major-national-origin-immigrant-groups-in-the-united-states
#16
Fernando Riosmena, Randall Kuhn, Warren C Jochem
Despite being newcomers, immigrants often exhibit better health relative to native-born populations in industrialized societies. We extend prior efforts to identify whether self-selection and/or protection explain this advantage. We examine migrant height and smoking levels just prior to immigration to test for self-selection; and we analyze smoking behavior since immigration, controlling for self-selection, to assess protection. We study individuals aged 20-49 from five major national origins: India, China, the Philippines, Mexico, and the Dominican Republic...
January 13, 2017: Demography
https://www.readbyqxmd.com/read/28092058/sub-regional-assessment-of-hpv-vaccination-among-female-adolescents-in-the-intermountain-west-and-implications-for-intervention-opportunities
#17
Julia Bodson, Qian Ding, Echo L Warner, Amy J Hawkins, Kevin A Henry, Deanna Kepka
Objectives We investigated the similarities and differences in the factors related to human papillomavirus (HPV) vaccination of female adolescents in three sub-regions of the Intermountain West (IW). Methods We analyzed 2011-2012 National Immunization Survey-Teen data. Respondents (parents) who were living in the IW and who had daughters aged 13-17 years old with provider-verified immunization records were included in our analyses. East, Central, and West sub-regions were defined based on geographic contiguity and similarity in HPV vaccination rates and sociodemographic characteristics...
January 13, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28091865/improving-the-diagnostic-workup-of-hyponatremia-in-the-setting-of-kidney-disease-a-continuing-medical-education-cme-initiative
#18
Ladan Golestaneh, Joel Neugarten, William Southern, Faraj Kargoli, Amanda Raff
PURPOSE: Hyponatremia is a common electrolyte disorder and is associated with mortality. We examined the frequency of appropriate testing in response to an episode of inpatient hyponatremia in a large urban hospital to better inform our educational intervention. We then evaluated the impact of a live CME activity with a focus on CKD- and ESRD-associated hyponatremia physiology, on diagnostic practices of audience hospitalist attendings. METHODS: We performed a retrospective database analysis of all patients admitted to Montefiore Medical Center in 2014 to examine the performance of hospital staff in response to hyponatremia across all CKD stages...
January 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28091353/the-development-of-a-national-nutrition-and-mental-health-research-agenda-with-comparison-of-priorities-among-diverse-stakeholders
#19
Karen M Davison, Carla D'Andreamatteo, Scott Mitchell, Pat Vanderkooy
OBJECTIVE: To develop a national nutrition and mental health research agenda based on the engagement of diverse stakeholders and to assess research priorities by stakeholder groups. DESIGN: A staged, integrated and participatory initiative was implemented to structure a national nutrition and mental health research agenda that included: (i) national stakeholder consultations to prioritize research questions; (ii) a workshop involving national representatives from research, policy and practice to further define priorities; (iii) triangulation of data to formulate the agenda; and (iv) test hypotheses about stakeholder influences on decision making...
January 16, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28091178/behavioral-assessment-of-listening-effort-using-a-dual-task-paradigm
#20
Jean-Pierre Gagné, Jana Besser, Ulrike Lemke
Published investigations ( n = 29) in which a dual-task experimental paradigm was employed to measure listening effort during speech understanding in younger and older adults were reviewed. A summary of the main findings reported in the articles is provided with respect to the participants' age-group and hearing status. Effects of different signal characteristics, such as the test modality, on dual-task outcomes are evaluated, and associations with cognitive abilities and self-report measures of listening effort are described...
January 2017: Trends in Hearing
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