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https://www.readbyqxmd.com/read/28432725/synthesis-and-biological-potency-of-anilino-triazine-insecticides
#1
Timothy C Johnson, Annette V Brown, Kristy K Bryan, Katherine K Guenthenspberger, Ricky Hunter, Timothy P Martin, Noormohamed Niyaz, Gene F Tisdell, Tony Trullinger
BACKGROUND: An insecticide screening effort identified N-(4-bromophenyl)-4,6-bis(2,2,2-trifluoroethoxy)-1,3,5-triazine-2-amine as having weak potency against two Lepidopteran species, Helicoverpa zea and Spodoptera exigua. A structure activity relationship study about the trifluoroethoxy substituents and the aniline of this compound was carried out in an effort to improve insecticidal potency. RESULTS: Initially, a series of analogs bearing various substituents on the aniline were prepared and the insecticidal potency was evaluated against Helicoverpa zea and Spodoptera exigua in greenhouse diet feeding assays...
April 22, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28432624/delivering-environmental-benefit-from-the-use-of-environmental-quality-standards-why-we-need-to-focus-on-implementation
#2
Graham Merrington, Adam Peters, Paul Whitehouse, Robin Clarke, Dan Merckel
The UK has adopted a broader approach to the introduction of Environmental Quality Standard (EQS) for the aquatic environment than many other jurisdictions around the world, with a greater focus on the implementation of scientifically derived standards. This follows the publication of a report by the Royal Commission on Environmental Pollution in 1998 which drew attention to the need to recognise that whilst an EQS is often just viewed as a numerical value, it also has other important characteristics that need to be recognised if it is to be a practical and effective regulatory tool...
April 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432211/recruiting-and-retaining-youth-and-young-adults-challenges-and-opportunities-in-survey-research-for-tobacco-control
#3
Jennifer Cantrell, Elizabeth C Hair, Alexandria Smith, Morgane Bennett, Jessica Miller Rath, Randall K Thomas, Mansour Fahimi, J Michael Dennis, Donna Vallone
INTRODUCTION: Evaluation studies of population-based tobacco control interventions often rely on large-scale survey data from numerous respondents across many geographic areas to provide evidence of their effectiveness. Significant challenges for survey research have emerged with the evolving communications landscape, particularly for surveying hard-to-reach populations such as youth and young adults. This study combines the comprehensive coverage of an address-based sampling (ABS) frame with the timeliness of online data collection to develop a nationally representative longitudinal cohort of young people aged 15-21...
April 21, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28431457/precision-medicine-and-pharmacogenetics-what-does-oncology-have-that-addiction-medicine-does-not
#4
Henry R Kranzler, Rachel V Smith, Robert Schnoll, Afaf Moustafa, Emma Greenstreet-Akman
BACKGROUND AND AIMS: Precision, personalized or stratified medicine, which promises to deliver the right treatment to the right patient, is a topic of international interest in both the lay press and the scientific literature. A key aspect of precision medicine is the identification of biomarkers that predict the response to medications (i.e. pharmacogenetics). We examined why, despite the great strides that have been made in biomarker identification in many areas of medicine, only in oncology has there been substantial progress in their clinical implementation...
April 21, 2017: Addiction
https://www.readbyqxmd.com/read/28431419/creation-and-validation-of-an-automated-algorithm-to-determine-postoperative-ventilator-requirements-after-cardiac-surgery
#5
Eilon Gabel, Ira S Hofer, Nancy Satou, Tristan Grogan, Richard Shemin, Aman Mahajan, Maxime Cannesson
BACKGROUND: In medical practice today, clinical data registries have become a powerful tool for measuring and driving quality improvement, especially among multicenter projects. Registries face the known problem of trying to create dependable and clear metrics from electronic medical records data, which are typically scattered and often based on unreliable data sources. The Society for Thoracic Surgery (STS) is one such example, and it supports manually collected data by trained clinical staff in an effort to obtain the highest-fidelity data possible...
May 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28431408/the-effects-of-exercise-modality-during-additional-high-intensity-interval-training-upon-aerobic-fitness-and-strength-in-powerlifting-and-strongman-athletes
#6
Patroklos Androulakis-Korakakis, Louis Langdown, Adam Lewis, James Fisher, Paulo Gentil, Antonio Paoli, James Steele
Powerlifters and strongman athletes have a necessity for optimal levels of muscular strength whilst maintaining sufficient aerobic capacity to perform and recover between events. HIIT has been popularized for its efficacy in improving both aerobic fitness and strength but never assessed within the aforementioned population group. The present study looked to compare the effect of exercise modality, e.g. a traditional aerobic mode (AM), and strength mode, (SM), during HIIT upon aerobic fitness and strength. Sixteen well resistance trained male participants, currently competing in powerlifting and strongman events, completed 8 weeks of approximately effort- and volume-matched HIIT in 2 groups: AM (cycling, n=8) and SM (resistance training, n=8)...
April 21, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28431345/insights-into-targeting-young-male-drivers-with-anti-speeding-advertising-an-application-of-the-step-approach-to-message-design-and-testing-satmdt
#7
I Lewis, K M White, B Ho, B Elliott, B Watson
In Australia, young drivers aged 17-25 years comprise 13% of the population yet account for 22% of all road deaths with young males over-represented in such trauma. Speeding represents a major contributing factor and advertising campaigns have long focused on promoting anti-speeding messages in the effort to reduce drivers' speeds. Positioned within a larger program of research aimed at developing, piloting, and evaluating a range of theoretically-informed anti-speeding messages, the current study reports results relating to the final phase of the research, the evaluation...
April 18, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28431031/sandbagging-on-the-immediate-post-concussion-assessment-and-cognitive-testing-impact-in-a-high-school-athlete-population
#8
Kathryn L Higgins, Robert L Denney, Arthur Maerlender
The Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is a computerized neuropsychological test battery commonly used to assess cognitive functioning after a concussion. It is recommended that application of ImPACT utilizes a baseline administration so athletes have an individualized baseline with which to compare post-injury results should they sustain a concussion. It has been suggested that athletes may provide suboptimal effort, called "sandbagging," in order to return to their baseline cognitive scores, and thus to play, more quickly...
May 1, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28430935/sensation-seeking-and-adolescent-alcohol-use-exploring-the-mediating-role-of-unstructured-socializing-with-peers
#9
Sharon Sznitman, Batya Engel-Yeger
Background: Researchers have theorized that adolescents high in sensation seeking are particularly sensitive to positive reinforcement and the rewarding outcomes of alcohol use, and thus that the personality vulnerability is a direct causal risk factor for alcohol use. In contrast, the routine activity perspective theorizes that part of the effect of sensation seeking on alcohol use goes through the propensity that sensation seekers have towards unstructured socializing with peers. The study tests a model with indirect and direct paths from sensation seeking and participation in unstructured peer socialization to adolescent alcohol use...
May 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28430797/effect-of-quinoline-based-1-2-3-triazole-and-its-structural-analogues-on-growth-and-virulence-attributes-of-candida-albicans
#10
Mohammad Irfan, Shadab Alam, Nikhat Manzoor, Mohammad Abid
Candida albicans, along with some other non-albicans Candida species, is a group of yeast, which causes serious infections in humans that can be both systemic and superficial. Despite the fact that extensive efforts have been put into the discovery of novel antifungal agents, the frequency of these fungal infections has increased drastically worldwide. In our quest for the discovery of novel antifungal compounds, we had previously synthesized and screened quinoline containing 1,2,3-triazole (3a) as a potent Candida spp inhibitor...
2017: PloS One
https://www.readbyqxmd.com/read/28430547/enhancing-insights-into-pulmonary-vascular-disease-pvd-through-a-precision-medicine-approach-a-joint-nhlbi-cmref-workshop-report
#11
John H Newman, Stuart Rich, Steven H Abman, John H Alexander, John Barnard, Gerald J Beck, Raymond L Benza, Todd M Bull, Stephen Y Chan, Hyung J Chun, Declan Doogan, Jocelyn Dupuis, Serpil C Erzurum, Robert P Frantz, Mark Geraci, Hunter Gillies, Mark Gladwin, Michael P Gray, Anna R Hemnes, Roy S Herbst, Adrian F Hernandez, Nicholas S Hill, Evelyn M Horn, Kendall Hunter, Zhi-Cheng Jing, Roger Johns, Sanjay Kaul, Steven M Kawut, Tim Lahm, Jane A Leopold, Greg D Lewis, Stephen C Mathai, Vallerie V McLaughlin, Evangelos D Michelakis, Steven D Nathan, William Nichols, Grier Page, Marlene Rabinovitch, Jonathan Rich, Franz Rischard, Sharon Rounds, Sanjiv J Shah, Victor F Tapson, Naomi Lowy, Norman Stockbridge, Gail Weinmann, Lei Xiao
The Division of Lung Diseases of the National Heart, Lung and Blood Institute, (NHLBI) and the Cardiovascular Medical Education and Research Fund (CMREF), held a workshop to discuss to leverage of the anticipated scientific output from the recently launched "Redefining Pulmonary Hypertension (PH) through Pulmonary Vascular Disease Phenomics" (PVDOMICS) program. PVDOMICS is a protocol driven network to analyze PH patient populations to define novel pulmonary vascular disease (PVD) phenotypes. Basic, translational and clinical investigators, patient advocacy organizations, regulatory agencies, and pharmaceutical industry experts discussed the application of precision medicine to PVD clinical trials...
April 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28430377/exploring-why-young-people-with-type%C3%A2-1-diabetes-decline-structured-education-with-a-view-to-overcoming-barriers
#12
V E Coates, G Horigan, M Davies, M T Davies
AIMS: To identify factors that influence lack of engagement of young adults with Type 1 diabetes (aged 13-21 years) with structured diabetes education (SDE) to inform and broaden the reach of future SDE. METHODS: A quantitative, cross-sectional survey was undertaken of 227 young people with Type 1 diabetes drawn from 11 health trusts across Northern Ireland and England, deemed to be representative of the wider population. Participants were asked to complete a questionnaire exploring non-attendance, along with the Diabetes Care Profile, the Diabetes Empowerment Scale (Short Form), the Diabetes Knowledge Test and the 12-item General Health Questionnaire...
April 21, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28429985/attitude-of-us-obstetricians-and-gynaecologists-to-global-warming-and-medical-waste
#13
Cassandra Thiel, Paula Duncan, Noe Woods
Objectives Global warming (or climate change) is a major public health issue, and health services are one of the largest contributors to greenhouse gas emissions in high-income countries. Despite the scale of the health care sector's resource consumption, little is known about the attitude of physicians and their willingness to participate in efforts to reduce the environmental impact of health services. Methods A survey of 236 obstetricians and gynaecologists at the University of Pittsburgh Medical Center in Western Pennsylvania, USA...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28429605/parent-perspectives-on-home-participation-of-high-functioning-children-with-autism-spectrum-disorder-compared-with-a-matched-group-of-children-without-autism-spectrum-disorder
#14
Snæfrídur T Egilson, Gunnhildur Jakobsdóttir, Linda B Ólafsdóttir
Few studies have focused on home participation of high-functioning children with autism spectrum disorder. We employed a mixed-methods design to explore and compare parent perspectives on (1) participation of children with and without autism spectrum disorder in activities at home, (2) the environmental features and resources that affect these children's home participation and (3) the strategies parents use to help their children participate at home. The Participation and Environment Measure for Children and Youth (PEM-CY) was used to gather online survey and qualitative data from parents of 99 high-functioning children with autism spectrum disorder and 241 children without autism spectrum disorder...
April 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28429393/synthesis-and-evaluation-of-thiazolidine-amide-and-n-thiazolyl-amide-fluoroquinolone-derivatives
#15
Isaac Garza, Miranda J Wallace, Dinesh Fernando, Aman Singh, Richard E Lee, Jason S Gerding, Cynthia Franklin, Raghunandan Yendapally
In an effort to develop new fluoroquinolones, we synthesized eight compounds and tested them against a panel of bacteria. The design of these compounds was guided by the introduction of the isothiazoloquinolone motif. The three most active compounds in this series, 8-10, demonstrated good antibacterial activity against methicillin-sensitive Staphylococcus aureus and healthcare-acquired methicillin-resistant Staphylococcus aureus (MIC 0.62-6.3 µg/mL). Further, when these three active compounds were tested for their inhibitory effects on bacterial enzymes, compound 9 was the most effective agent exhibiting IC50 values of 33...
April 21, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28429170/comparison-of-energy-balance-between-two-different-sized-groups-of-japanese-macaques-macaca-fuscata-yakui
#16
Yosuke Kurihara, Goro Hanya
Quantifying the energy balance is essential for testing socio-ecological models. To reveal costs and benefits of group living in Japanese macaques from the perspective of feeding competition, Kurihara and Hanya (Am J Primatol 77:986-1000, 2015) previously compared feeding behavior between two different-sized groups of macaques (larger group 30-35 individuals; smaller group 13-15 individuals) in the coastal forest of Yakushima, Japan. The results suggested that the larger group exhibited greater feeding effort because of intragroup scramble competition and that the smaller group suffered from higher travel costs, possibly owing to intergroup contest competition...
April 20, 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28428982/biomechanical-effect-of-pedicle-screw-distribution-in-ais-instrumentation-using-a-segmental-translation-technique-computer-modeling-and-simulation
#17
Xiaoyu Wang, A Noelle Larson, Dennis G Crandall, Stefan Parent, Hubert Labelle, Charles G T Ledonio, Carl-Eric Aubin
BACKGROUND: Efforts to select the appropriate number of implants in adolescent idiopathic scoliosis (AIS) instrumentation are hampered by a lack of biomechanical studies. The objective was to biomechanically evaluate screw density at different regions in the curve for AIS correction to test the hypothesis that alternative screw patterns do not compromise anticipated correction in AIS when using a segmental translation technique. METHODS: Instrumentation simulations were computationally performed for 10 AIS cases...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28428864/integrating-biogeography-threat-and-evolutionary-data-to-explore-extinction-crisis-in-the-taxonomic-group-of-cycads
#18
Kowiyou Yessoufou, Barnabas H Daru, Respinah Tafirei, Hosam O Elansary, Isaac Rampedi
Will the ongoing extinction crisis cause a severe loss of evolutionary information accumulated over millions of years on the tree of life? This question has been largely explored, particularly for vertebrates and angiosperms. However, no equivalent effort has been devoted to gymnosperms. Here, we address this question focusing on cycads, the gymnosperm group exhibiting the highest proportion of threatened species in the plant kingdom. We assembled the first complete phylogeny of cycads and assessed how species loss under three scenarios would impact the cycad tree of life...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28428642/-technology-and-prevention-in-the-era-of-mobile-health-applications-for-cancer-screening-programs
#19
Fabrizio Bert, Maria Rosaria Gualano, Salvatore Clemente, Giulia Villa, Roberta Siliquini
The Italian national health system provides screening to detect breast, colorecatal and cervical cancers, however, population adherence is not as high as expected. Smartphones and their applications (apps) could be used as a tool to communicate with the population and to help improve adherence. The aim of this study was to analyze the features and functions of smartphone applications aimed at secondary prevention of oncological diseases. In February 2016, we reviewed online app stores, using specific key-words, to search for available apps for cancer screening...
January 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28428597/outcomes-and-costs-of-pre-school-and-school-based-fluoride-varnish-pilots
#20
S Buckingham, J H John
Objective Fluoride varnish (FV) applications reduce the risk of dental decay in research trials. These pilots were conducted to test the feasibility and costs of providing FV applications in schools. Changes in dental decay levels were also monitored.Methods Data were collected on the proportion of children with dental decay, mean number of teeth affected and whether the child had attended for dental care. The cost of delivering the intervention was calculated.Results More children were reported to be attending for dental care by the end of the pilot than at the start...
April 21, 2017: British Dental Journal
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