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https://www.readbyqxmd.com/read/29196339/intra-abdominal-infection-combined-with-intra-abdominal-hypertension-aggravates-the-intestinal-mucosal-barrier-dysfunction
#1
Yuan Li, Jianan Ren, Xiuwen Wu, Jieshou Li
Some patients with intra-abdominal infection (IAI) may develop intra-abdominal hypertension (IAH) during treatment. This study investigated the impact of IAI combined with IAH on the intestinal mucosal barrier in a rabbit model. Forty-eight New Zealand white rabbits were randomly divided into four groups: (1) IAI & IAH; (2) IAI alone; (3) IAH alone; and (4) Control group. IAI model: cecal ligation and puncture for 48 hours; IAH model: raised intra-abdominal pressure of 20 mmHg for 4 hours. Pathological changes of intestinal mucosa were confirmed by light and scanning electron microscopy...
December 1, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29182210/the-role-of-point-of-care-ultrasound-in-intra-abdominal-hypertension-management
#2
Bruno M Pereira, Renato G Pereira, Robert Wise, Gavin Sugrue, Tanya L Zachrison, Alcir E Dorigatti, Rossano K Fiorelli, Manu L N G Malbrain
BACKGROUND: Intra-abdominal hypertension is a common complication in critically ill patients. Recently the Abdominal Compartment Society (WSACS) developed a medical management algorithm with a stepwise approach according to the evolution of the intra-abdominal pressure and aiming to keep IAP ≤ 15 mm Hg. With the increased use of ultrasound as a bedside modality in both emergency and critical care patients, we hypothesized that ultrasound could be used as an adjuvant point-of-care tool during IAH management...
November 28, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29173983/-how-to-explain-glomerular-filtration-rate-decrease-in-intra-abdominal-hypertension
#3
Vincent Dupont, Alexandre Debrumetz, Alain Wynckel, Philippe Rieu
Intra-abdominal hypertension (IAH) is a frequent and serious condition affecting critical care patients. IAH diagnostic needs intravesical pressure (IVP) measurement which is recommended for monitoring patients presenting IAH risk factors. IVP monitoring is probably insufficient in daily practice. This could be explained by lack of knowledge about IAH physiopathology, which leads to absence of therapeutic target. Acute kidney injury (AKI) is the earliest and most described organ dysfunction associated with IAH...
November 23, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29171001/modern-imaging-techniques-in-intra-abdominal-hypertension-and-abdominal-compartment-syndrome-a-bench-to-bedside-overview
#4
Gavin Sugrue, Manu L N G Malbrain, Bruno Pereira, Robert Wise, Michael Sugrue
Intra-abdominal hypertension (IAH) is common in critically ill patients. Diagnosis is based on measurement of intra-abdominal pressure, most commonly via the bladder. Modern imaging techniques with plain radiographs, computed tomography and magnetic resonance can help establish the diagnosis and also guide treatment. In 2013 the Abdominal Compartment Society (WSACS) published updated consensus definitions and recommendations for management of IAH and abdominal compartment syndrome (ACS). This review will give a concise overview of the important role radiographic imaging plays within these management guidelines...
November 24, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29135425/internationalization-in-an-occupational-therapy-curriculum-a-philippine-american-pilot-collaboration
#5
Maria Concepcion C Cabatan, Lenin C Grajo
OBJECTIVE: This study is a pilot implementation of an Internationalization at Home (IaH) teaching and learning collaboration to enhance intercultural learning and understanding of concepts of occupation in two cohorts of occupational science and occupational therapy students from the Philippines and the United States. METHOD: In this collective case study, 149 students (Cohort 1, n = 65; Cohort 2, n = 84) participated. The collaboration included virtual conversations among students, faculty presentations, reflective assignments, and completion of an anonymous online survey...
November 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29119060/intra-abdominal-hypertension-in-severe-burns-prevalence-incidence-and-mortality-in-a-sub-saharan-african-hospital
#6
Ronald Mbiine, Rose Alenyo, Olive Kobusingye, Job Kuteesa, Cephas Nakanwagi, Hervé Monka Lekuya, Olivia Kituuka, Moses Galukande
BACKGROUND: Severe burns have been shown to be a risk factor for developing intra-abdominal hypertension (IAH). Fluid resuscitation practices used in burns management further predispose patients to intra-abdominal hypertension. The mortality associated with IAH in severe burns is estimated to be more than 74.5% once organ dysfunction occurs. Despite 95% of all burns occurring in Low and Middle income countries (LMIC), there is paucity of published data on this topic in sub-Saharan Africa...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29054769/positive-end-expiratory-pressure-adjusted-for-intra-abdominal-pressure-a-pilot-study
#7
Adrian Regli, Bart Leon De Keulenaer, Annamaria Palermo, Peter Vernon van Heerden
PURPOSE: Intra-abdominal hypertension (IAH) is associated with impaired respiratory function. Animal data suggest that positive end-expiratory pressure (PEEP) levels adjusted to intra-abdominal pressure (IAP) levels may counteract IAH-induced respiratory dysfunction. In this pilot study, our aim was to assess whether PEEP adjusted for IAP can be applied safely in patients with IAH. MATERIALS AND METHODS: We included patients on mechanical ventilation and with IAH...
October 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29054335/the-relation-between-hba1c-and-hypoglycemia-revisited-a-secondary-analysis-from-an-intervention-trial-in-patients-with-type-1-diabetes-and-impaired-awareness-of-hypoglycemia
#8
Cornelis A J van Beers, Martine G Caris, J Hans DeVries, Erik H Serné
AIMS: We aimed to re-assess the previously shown but recently disputed association between HbA1c and severe hypoglycemia. METHODS: 52 Patients with T1D and IAH participated in an earlier reported randomized, crossover trial with two 16-week intervention periods comparing continuous glucose monitoring (CGM) with self-monitoring of blood glucose (SMBG). In this previous study, time spent in normoglycemia (the primary outcome), was improved by 9.6% (p<0.0001). We performed post-hoc analyses using a zero-inflated Poisson regression model to assess the relationship between severe hypoglycemia and HbA1c, glucose variability and duration of diabetes...
September 18, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28993722/type-1-diabetes-and-impaired-awareness-of-hypoglycemia-are-associated-with-reduced-brain-gray-matter-volumes
#9
Petr Bednarik, Amir A Moheet, Heidi Grohn, Anjali F Kumar, Lynn E Eberly, Elizabeth R Seaquist, Silvia Mangia
In this study, we retrospectively analyzed the anatomical MRI data acquired from 52 subjects with type 1 diabetes (26M/26F, 36 ± 11 years old, A1C = 7.2 ± 0.9%) and 50 age, sex and BMI frequency-matched non-diabetic controls (25M/25F, 36 ± 14 years old). The T1D group was further sub-divided based on whether subjects had normal, impaired, or indeterminate awareness of hypoglycemia (n = 31, 20, and 1, respectively). Our goals were to test whether the gray matter (GM) volumes of selected brain regions were associated with diabetes status as well as with the status of hypoglycemia awareness...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28964859/pathogen-invasion-changes-the-intestinal-microbiota-composition-and-induces-innate-immune-responses-in-the-zebrafish-intestine
#10
Hui-Ting Yang, Song-Song Zou, Li-Juan Zhai, Yao Wang, Fu-Miao Zhang, Li-Guo An, Gui-Wen Yang
Numerous bacteria are harbored in the animal digestive tract and are impacted by several factors. Intestinal microbiota homeostasis is critical for maintaining the health of an organism. However, how pathogen invasion affects the microbiota composition has not been fully clarified. The mechanisms for preventing invasion by pathogenic microorganisms are yet to be elucidated. Zebrafish is a useful model for developmental biology, and studies in this organism have gradually become focused on intestinal immunity...
September 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28935628/effect-of-exercise-induced-lactate-elevation-on-brain-lactate-levels-during-hypoglycemia-in-patients-with-type-1-diabetes-and-impaired-awareness-of-hypoglycemia
#11
Evita C Wiegers, Hanne M Rooijackers, Cees J Tack, Hans J M M Groenewoud, Arend Heerschap, Bastiaan E de Galan, Marinette van der Graaf
Since altered brain lactate handling has been implicated in the development of impaired awareness of hypoglycemia (IAH) in type 1 diabetes, the capacity to transport lactate into the brain during hypoglycemia may be relevant in its pathogenesis. High-intensity interval training (HIIT) increases plasma lactate levels. We compared the effect of HIIT-induced hyperlacticacidemia on brain lactate during hypoglycemia between 1) patients with type 1 diabetes and IAH, 2) patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), and 3) healthy non-diabetic participants (n=6 per group)...
September 21, 2017: Diabetes
https://www.readbyqxmd.com/read/28780148/intraabdominal-hypertension-abdominal-compartment-syndrome-and-the-open-abdomen
#12
REVIEW
William Kirke Rogers, Luis Garcia
Abdominal compartment syndrome (ACS) is the end point of a process whereby massive interstitial swelling in the abdomen or rapid development of a space-filling lesion in the abdomen (such as ascites or a hematoma) leads to pathologically increased pressure. This results in so-called intraabdominal hypertension (IAH), causing decreased perfusion of the kidneys and abdominal viscera and possible difficulties with ventilation and maintenance of cardiac output. These effects contribute to a cascade of ischemia and multiple organ dysfunction with high mortality...
August 2, 2017: Chest
https://www.readbyqxmd.com/read/28774945/arteriolar-hyalinosis-predicts-increase-in-albuminuria-and-gfr-decline-in-normo-and-microalbuminuric-japanese-patients-with-type-2-diabetes
#13
Tatsumi Moriya, Kazuki Omura, Madoka Matsubara, Yuki Yoshida, Kei Hayama, Motoshi Ouchi
OBJECTIVE: This study investigated the association between renal histology, as assessed by morphometric analysis using light (LM) and electron (EM) microscopy, and changes in urinary albumin excretion (UAE) and glomerular filtration rate (GFR) in Japanese people with type 2 diabetes in the early stages of diabetic nephropathy. RESEARCH DESIGN AND METHODS: We performed percutaneous renal biopsies in 29 patients with type 2 diabetes (22 men, mean ± SD age 49 ± 10 years and GFR 119 ± 27 mL/min/1...
August 3, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28694568/the-role-of-routine-measurement-of-intra-abdominal-pressure-in-preventing-abdominal-compartment-syndrome
#14
G Raghavendra Prasad, J V Subba Rao, Amtul Aziz, T M Rashmi
INTRODUCTION: Abdomen, a closed compartment, is prone to raised intra-abdominal pressure (IAP) in the postoperative period. After a critical value of ≥ 15 cm of water, IAP produces abdominal compartment syndrome (ACS). ACS leads to reduced venous return, reduced cardiac output, and domino effect of organ dysfunction, leading to death. Hence, it is the need of hour to monitor IAP to pick up intra-abdominal hypertension (IAH) and ACS. This routine facilitates early institution of treatment measures...
July 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28692628/genetic-determinants-of-impaired-awareness-of-hypoglycemia-in-type-1-diabetes
#15
Bas J Schouwenberg, Marieke J Coenen, Andrew D Paterson, Cees J Tack, Paul Smits, Cornelis Kramers, Bastiaan E de Galan
OBJECTIVE: It is likely that impaired awareness of hypoglycemia (IAH) and severe hypoglycemia are in part determined by genetic factors. The aim of this study was to investigate candidate genes for associations with IAH and severe hypoglycemia in a cohort of patients with type 1 diabetes. PARTICIPANTS AND METHODS: Consecutive patients with type 1 diabetes were genotyped for single-nucleotide polymorphisms in or near the genes for the β1 and β2 adrenergic receptor (ADRB1, ADRB2), SORCS1, and BNC2, and for the insertion/deletion polymorphism in the ACE gene...
September 2017: Pharmacogenetics and Genomics
https://www.readbyqxmd.com/read/28685797/impact-of-obstructive-sleep-apnea-on-the-right-ventricle
#16
Lilia Zakhama, Besma Herbegue, Maher Abouda, Saoussen Antit, Iskander Slama, Elhem Boussabah, Moez Thameur, Mourad Masmoudi, Nabil Abdelaali, Mohamed Ridha Charfi, Soraya Ben Youssef
BACKGROUND: Right ventricular (RV) involvement in obstructive sleep apnea syndrome (OAS) is controversial. The aim of this study was to determine a correlation between echocardiographic parameters of RV function and severity of OSA assessed by the apnea- hypopnea index (AHI). METHODS: Sixty patients with suspected OSA were enrolled. All patients had overnight polygraphy and an echocardiographic assessment of RV structure and function. Patients were divided into three groups: a control group (n=20) with an AHI<5/h, a group of mild to moderate OSA (n=18) with an AHI=5-30/h and a group of severe OSA (n=22) with AHI≥30/h...
October 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28673010/rhubarb-vs-glycerin-enema-for-treatment-of-critically-ill-patients-with-intra-abdominal-hypertension
#17
Bing Wan, Hao Zhang, Jiangtao Yin, Haiyan Fu, Yikun Chen, Liping Yang, Dadong Liu, Tangfeng Lv, Yong Song
Rhubarb has been used as an evacuant for thousands of years. However, recent research has indicated that rhubarb inhibits inflammation and protects organ function. In the current study, the use of rhubarb was investigated in patients with intra-abdominal hypertension (IAH). Specifically, its dual role in attenuating lung and bowel injury by catharsis and inhibiting inflammation was evaluated. Patients in the glycerin group (n=56) received 110 ml of glycerin enema by coloclysis once daily for 7 to 9 days. Patients in the rhubarb group (n=56) were treated with a mixture of 0...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28634533/a-study-to-evaluate-the-prevalence-of-impaired-awareness-of-hypoglycaemia-in-adults-with-type-2-diabetes-in-outpatient-clinic-in-a-tertiary-care-centre-in-singapore
#18
Ling Zhu, Li Chang Ang, Wee Boon Tan, Xiaohui Xin, Yong Mong Bee, Su-Yen Goh, Ming Ming Teh
BACKGROUND: Impaired awareness of hypoglycaemia (IAH) predisposes affected patients to severe hypoglycaemia. There are few data on prevalence of IAH in adults with insulin-treated type 2 diabetes in Asia. We aim to ascertain the prevalence of IAH among insulin-treated patients with type 2 diabetes in an outpatient clinic in a tertiary care centre in Singapore. METHODS: A total of 374 patients with insulin-treated type 2 diabetes attending the outpatient diabetes clinic in a tertiary referral centre in Singapore were recruited over a 4-month period...
May 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28618765/the-influence-of-intraabdominal-pressure-on-the-mortality-rate-of-patients-with-acute-pancreatitis
#19
Petar Svorcan, Maja Stojanovic, Predrag Stevanovic, Aleksadar Karamarkovic, Radmilo Jankovic, Nebojsa Ladjevic
BACKGROUND/AIM: Intraabdominal hypertension (IAH) is a common clinical finding in patients with acute pancreatitis and is associated with poor prognosis. This study aimed to determine the impact of intraabdominal pressure (IAP) on the mortality rate in patients with acute pancreatitis in an intensive care unit. MATERIALS AND METHODS: A total of 50 patients with acute pancreatitis were included in this prospective cohort study. Based on the obtained values of IAP, the patients were divided into two groups: those with normal IAP (n = 14) and increased IAP (n = 36)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28614762/intra-abdominal-hypertension-and-abdominal-compartment-syndrome-in-pediatrics-a-review
#20
REVIEW
Farah Chedly Thabet, Janeth Chiaka Ejike
PURPOSE: To consolidate pediatric intensivists' understanding of the pathophysiology, definition, incidence, monitoring, and management of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS); and to highlight the characteristics related to the pediatric population. METHODS: This is a narrative review article that utilized a systematic search of the medical literature published in the English language between January 1990 and august 2016. Studies were identified by conducting a comprehensive search of Pub Med databases...
October 2017: Journal of Critical Care
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