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https://www.readbyqxmd.com/read/28330440/prevalence-and-predictors-of-intra-abdominal-hypertension-and-compartment-syndrome-in-surgical-patients-in-critical-care-units-at-kenyatta-national-hospital
#1
A Muturi, P Ndaguatha, Daniel Ojuka, A Kibet
BACKGROUND: Intra-abdominal hypertension (IAH) affects almost every organ sytem.If it is not detected early and corrected, mortality would be high. The prevalence of IAH and abdominal compartment syndrome (ACS) at Kenyatta National Hospital (KNH) critical care units is not known. The aim of this sudy was to determine the prevalence and factors associated with development of IAH/ACS among critically ill surgical patients. METHODS: This was a cross sectional descriptive study involving surgical patients in critical care units at KNH, carried out from March 2015 to October 2015...
March 23, 2017: BMC Emergency Medicine
https://www.readbyqxmd.com/read/28282605/variations-of-renal-tissue-oxygenation-during-abdominal-compartment-syndrome-and-sepsis
#2
Stavros Kalfadis, Vaia Nalbanti, Orestis Ioannidis, George Porfiriou, Dimitrios Botsios, Konstantinos Tsalis
PURPOSE: This experimental study was designed to evaluate the renal tissue oxygenation under the coexistence of abdominal compartment syndrome and sepsis. MATERIAL AND METHODS: Fourteen non-breed dogs were divided into two groups: the control group (8) and the study group (6). Sepsis was established with intravenous endotoxin infusion at 100μg/kg for over 30min. Insufflation of CO2 in the peritoneal cavity was used for the increase in intra-abdominal pressure (IAP)...
March 7, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28270522/high-intensity-exercise-as-a-dishabituating-stimulus-restores-counterregulatory-responses-in-recurrently-hypoglycemic-rodents
#3
Alison D McNeilly, Jennifer R Gallagher, Jeffrey T-J Huang, Michael L J Ashford, Rory J McCrimmon
Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to hypoglycemia explain the frequency of hypoglycemia occurrence in T1D. Defective counterregulation results to a large extent from prior exposure to hypoglycemia per se, leading to a condition called impaired awareness of hypoglycemia (IAH); the cause of which is unknown. In the present study, we investigate the hypothesis that IAH develops through a special type of adaptive memory referred to as habituation...
March 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28255145/infection-associated-haemophagocytic-syndrome-in-severe-dengue-infection-a-case-series-in-a-district-hospital
#4
Y S Y Jasmine, S L Lee, F K Kan
Haemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disorder resulting from uncontrolled hyperinflammatory response. There had been increase in cases of one of the secondary form of HLH, i.e., infectionassociated haemophagocytic syndrome (IAHS) in severe dengue in recent years. However, the condition remains under diagnosed due to lack of awareness compounded by the lack of validated diagnostic criteria. Severe hepatitis with prolonged cytopenias, severe hyperferritinemia, hypofibrinogenemia and persistent fever were evident in all four cases reported...
February 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28243924/the-respiratory-pressure-abdominal-volume-curve-in-a-porcine-model
#5
Adrian Regli, Bart Leon De Keulenaer, Bhajan Singh, Lisen Emma Hockings, Bill Noffsinger, Peter Vernon van Heerden
BACKGROUND: Increasing intra-abdominal volume (IAV) can lead to intra-abdominal hypertension (IAH) or abdominal compartment syndrome. Both are associated with raised morbidity and mortality. IAH can increase airway pressures and impair ventilation. The relationship between increasing IAV and airway pressures is not known. We therefore assessed the effect of increasing IAV on airway and intra-abdominal pressures (IAP). METHODS: Seven pigs (41.4 +/-8.5 kg) received standardized anesthesia and mechanical ventilation...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28225498/dengue-associated-hemophagocytic-lymphohistiocytosis-in-an-adult-a-case-report-and-literature-review
#6
REVIEW
Sang Mi Chung, Joon Young Song, Wonshik Kim, Min Joo Choi, Ji Ho Jeon, Seonghui Kang, Eunju Jung, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim
BACKGROUND: Infection-associated hemophagocytic syndrome (IAHS) is potentially a fatal disease caused by systemic infection complicated by hemophagocyticlymphohistiocytosis (HLH). Here, we report a case of HLH associated with dengue hemorrhagic fever (DHF) after a trip to Thailand. CASE SUMMARY: A 33-year-old healthy female patient presented with 3 days of fever, myalgia, and skin rash. Serotype 3 dengue virus was isolated. Clinical and laboratory findings fulfilled the criteria of HLH...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28123648/effectiveness-of-maxillomandibular-advancement-mma-surgery-in-sleep-apnea-treatment-case-report
#7
Otávio Ferraz, Thais M Guimarães, Rowdley R Rossi, Paulo A Cunali, Cibele Dal Fabbro, Cauby M Chaves, Milton Maluly, Lia Bittencourt, Sergio Tufik
Obstructive sleep apnea (OSA) is characterized by episodes of pharyngeal collapse during sleep. Craniofacial alterations such as retrognathia are often found in OSA patients. Maxillomandibular advancement (MMA) surgeries increase the pharyngeal space and are a treatment option for OSA. The aim of this study was to present a successful case of MMA surgery in the treatment of OSA. A patient with moderate OSA (apnea-hypopnea index (AHI)=25.2) and mandibular retrognathism and Maxillomandibular asymmetry underwent MMA surgery...
July 2016: Sleep Science
https://www.readbyqxmd.com/read/28115398/pro-inflammatory-effects-of-hypoglycemia-in-humans-with-or-without-diabetes
#8
Jacqueline M Ratter, Hanne M M Rooijackers, Cees J Tack, Anneke G M Hijmans, Mihai G Netea, Bastiaan E de Galan, Rinke Stienstra
Severe hypoglycemic events have been associated with increased cardiovascular mortality in patients with diabetes, which may be explained by hypoglycemia-induced inflammation. We used ex vivo stimulations of peripheral blood mononuclear cells (PBMCs) and monocytes obtained during hyperinsulinemic euglycemic (5.0 mmol/L)-hypoglycemic (2.6 mmol/L) clamps in 11 healthy participants, 10 patients with type 1 diabetes with normal awareness of hypoglycemia (NAH) and 10 patients with impaired awareness (IAH) to test whether the composition and inflammatory function of immune cells adapt a more pro-inflammatory state after hypoglycemia...
January 23, 2017: Diabetes
https://www.readbyqxmd.com/read/28062177/maxillomandibular-advancement-for-obstructive-sleep-apnea-syndrome-treatment-long-term-results
#9
Aurélie Vigneron, Renaud Tamisier, Emmanuelle Orset, Jean-Louis Pepin, Georges Bettega
PURPOSE: We evaluated the long term effectiveness of maxillomandibular advancement (MMA) for OSAS treatment patients. This retrospective study reviewed the patients treated by MMA for OSAS between 1995 and 2009. They were evaluated by complete polysomnography, cephalometry and quality of life questionnaire. The minimum follow up was 3 years. Success rate was defined by an IAH <10 with at least a 50% reduction. MATERIAL AND METHODS: 88 patients had MMA during this period...
December 7, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28029353/intra-abdominal-hypertension-increases-spatial-qrs-t-angle-and-elevates-st-segment-j-point-in-healthy-women-undergoing-laparoscopic-surgery
#10
Wojciech Dabrowski, Andrzej Jaroszynski, Anna Jaroszynska, Ziemowit Rzecki, Todd T Schlegel, Manu Lng Malbrain
BACKGROUND: Intra-abdominal hypertension (IAH) impairs cardiovascular function, however an effect of IAH on cardiac electrophysiology has been poorly documented. The aim of this study was to evaluate the effect of IAH following pneumoperitoneum on vectorcardiographic variables reflecting cardiac repolarisation and depolarisation. METHODS: Otherwise healthy women undergoing elective gynaecological laparoscopy were studied. Intra-abdominal pressure (IAP), spatial QRS-T angle and ST-segment J-point (STJ) were observed during surgery and the early postoperative period...
March 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/27993524/severe-hypoglycemia-impaired-awareness-of-hypoglycemia-and-self-monitoring-in-adults-with-type-1-diabetes-results-from-diabetes-miles-australia
#11
Christel Hendrieckx, Virginia Hagger, Alicia Jenkins, Timothy Chas Skinner, Frans Pouwer, Jane Speight
AIMS: To assess prevalence of severe hypoglycemia, awareness and symptoms of hypoglycemia, and their associations with self-monitoring of blood glucose. METHODS: Diabetes MILES-Australia Study participants completed validated questionnaires and study-specific items. RESULTS: Of 642 adults with type 1 diabetes, 21% reported ≥1 severe hypoglycemic event in the past six months, and 21% reported impaired awareness of hypoglycemia (IAH). Severe hypoglycemia was increased four-fold for those with IAH compared with intact awareness (1...
March 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27984823/hydrochlorothiazide-in-intensive-care-unit-acquired-hypernatremia-a-randomized-controlled-trial
#12
Marjolein M C O van IJzendoorn, Hanneke Buter, W Peter Kingma, Matty Koopmans, Gerjan Navis, E Christiaan Boerma
PURPOSE: Thiazides are suggested as a treatment for intensive care unit (ICU)-acquired hypernatremia (IAH). The primary aim of the study was reducing serum sodium concentration (sNa) in patients with IAH with hydrochlorothiazide (HCT) in comparison to placebo. Secondary end points were a difference in urine sodium concentration (uNa) and duration of severe IAH. MATERIALS: A monocentric, double-blind, placebo-controlled trial was conducted in 50 patients with IAH and urine potassium + uNa less than sNa in a spot urine sample...
April 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/27924224/micu1-may-be-a-promising-intervention-target-for-gut-derived-sepsis-induced-by-intra-abdominal-hypertension
#13
Yuxin Leng, Qinggang Ge, Zhiling Zhao, Kun Wang, Gaiqi Yao
Intra-abdominal hypertension (IAH) is a common and serious complication in critically ill patients, for which there is no targeted therapy. IAH-induced dysfunction of intestinal barriers is closely associated with oxidative imbalances, which are considered to provide a pathophysiological basis for subsequent gut-derived sepsis. However, the upstream mechanism that produces oxidative damage during IAH remains unknown. It is not clear whether 'mitochondrial Ca(2+) uptake 1' (MICU1, the key protein regulating the oxidative process) is involved in preventing Ca(2+)m (mitochondrial Ca(2+)) overload...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27862736/reduced-prevalence-of-impaired-awareness-of-hypoglycemia-in-a-population-based-clinic-sample-of-youth-with-type-1-diabetes
#14
Mary B Abraham, Patricia H Gallego, Wade M Brownlee, Grant J Smith, Elizabeth A Davis, Timothy W Jones
BACKGROUND: Impaired awareness of hypoglycemia (IAH) is associated with an increased risk for severe hypoglycemia (SH). However, reduced rates of SH raise the question as to whether there has been a reduction in IAH. The aim of this study was to determine the change in prevalence of IAH in a population-based cohort of adolescents with Type 1 diabetes (T1D). METHODS: Children older than 12 years with T1D documented their responses to hypoglycemia based on the modified Clarke questionnaire...
November 11, 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27844014/genetic-va-riation-in-the-na-rrow-c-lawed-c-ra-yfish-astacus-lepto-dactylus-po-pulatio-ns-as-assesse-d-by-pcr-rflp-of-mitochondria-l-coi-gene
#15
Majidreza Khos Hkholgh, Sajad Nazari
The genetic variation and population structure of narrow-clawed crayfish (Astacus leptodactylus) was examined by means of polymerase chain reaction (PC R) restriction fragment length polymorphism (RF LP) analysis of the cytochrome oxidase subunit I (COI) of mitochondrial DNA. A total of 194 adult specimens were collected from seven sample sites including, two in the south Caspian Sea and one each in Anzali wetland and Aras reservoir and three rivers Chafrood, Masule Rudkhan and S iah Darvishan. The PCR products were digested with 19 restriction enzymes and five enzymes revealed polymorphism patterns (DdeІ, MboІ, TaqI, RsaІ and HinfІ)...
December 2015: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/27833483/acquired-hypernatremia-in-a-general-surgical-intensive-care-unit-incidence-and-prognosis
#16
Mariam A Alansari, Ahmed Abdulmomen, Mohammed Hussein, Ahmad Mohmmad Zubaidi, Jalal T Alswaiti
PURPOSE: Intensive Care Unit (ICU)-acquired hypernatremia (IAH) is a serious electrolyte disturbance that recently was shown to present an independent risk factor for mortality in critically ill patients. IAH has not been widely investigated in Surgical ICU (SICU) patients. No study has specifically investigated IAH epidemiology in the Kingdome of Saudi Arabia (KSA) in general SICU. The objectives of this study are to assess the epidemiological characteristics and prognostic impact of IAH on SICU mortality and outcome in KSA and compare it with international figures...
October 2016: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/27832556/can-femoral-venous-pressure-be-used-as-an-estimate-for-standard-vesical-intra-abdominal-pressure-measurement
#17
A E Howard, A Regli, E Litton, M M Malbrain, A-M Palermo, B L De Keulenaer
Intra-abdominal hypertension (IAH) is highly prevalent in critically ill patients admitted to the intensive care unit and is associated with an increased morbidity and mortality. The present study investigated whether femoral venous pressure (FVP) can be used as a surrogate parameter for intra-abdominal pressure (IAP) measured via the bladder in IAH grade II (IAP <20 mmHg) or grade III (IAP ≥20 mmHg). This was a single-centre prospective study carried out in a tertiary adult intensive care unit. IAP was measured via the bladder with a urinary catheter with simultaneous recording of the FVP via a femoral central line...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27794083/the-effect-of-compartmental-asymmetry-on-the-monitoring-of-pulmonary-mechanics-and-lung-volumes
#18
Joseph C Keenan, Gustavo A Cortes-Puentes, Alexander B Adams, David J Dries, John J Marini
BACKGROUND: Esophageal pressure measurement for computation of transpulmonary pressure (Ptp) has begun to be incorporated into clinical use for evaluating forces across the lungs. Gaps exist in our understanding of how esophageal pressure (and therefore Ptp), a value measured at a single site, responds when respiratory system compartments are asymmetrically affected by whole-lung atelectasis or unilateral injury as well as changes in chest wall compliance. We reasoned that Ptp would track with aerated volume changes as estimated by functional residual capacity (FRC) and tidal volume...
November 2016: Respiratory Care
https://www.readbyqxmd.com/read/27726116/how-central-obesity-influences-intra-abdominal-pressure-a-prospective-observational-study-in-cardiothoracic-surgical-patients
#19
Marije Smit, Maureen J M Werner, Annemieke Oude Lansink-Hartgring, Willem Dieperink, Jan G Zijlstra, Matijs van Meurs
BACKGROUND: Intra-abdominal hypertension (IAH) is frequently present in critically ill patients and is an independent predictor for mortality. Better recognition of clinically important thresholds is necessary. Increased intra-abdominal pressure (IAP) is associated with renal dysfunction, and renal failure is one of the most consistently described organ dysfunctions associated with IAH. Obesity is also associated with kidney injury. The underlying mechanisms are not yet fully understood...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27703807/the-development-of-intensive-care-unit-acquired-hypernatremia-is-not-explained-by-sodium-overload-or-water-deficit-a-retrospective-cohort-study-on-water-balance-and-sodium-handling
#20
M C O van IJzendoorn, H Buter, W P Kingma, G J Navis, E C Boerma
Background. ICU acquired hypernatremia (IAH, serum sodium concentration (sNa) ≥ 143 mmol/L) is mainly considered iatrogenic, induced by sodium overload and water deficit. Main goal of the current paper was to answer the following questions: Can the development of IAH indeed be explained by sodium intake and water balance? Or can it be explained by renal cation excretion? Methods. Two retrospective studies were conducted: a balance study in 97 ICU patients with and without IAH and a survey on renal cation excretion in 115 patients with IAH...
2016: Critical Care Research and Practice
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