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Quaternary Prevention

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https://www.readbyqxmd.com/read/28882196/simultaneous-determination-of-acetylsalicylic-acid-hydrochlorothiazide-enalapril-and-atorvastatin-in-a-polypill-based-quaternary-mixture-by-tlc
#1
Anna Maślanka, Mariusz Stolarczyk, Anna Apola, Anna Kwiecień, Urszula Hubicka, Włodzimierz Opoka
A new chromatographic-densitometric method has been developed for the qualitative and quantitative determination of the active ingredients in a simulated mixture corresponding to the PolyIran polypill, composed of acetylsalicylic acid, hydrochlorothiazide (HCT), enalapril (ENA), and atorvastatin (ATR), whose efficacy in the treatment and prevention of cardiovascular disease has been documented in clinical trials. Chromatographic separation was performed using TLC silica gel 60 plates with fluorescent indicator F254 as the stationary phase and a mixture of n-hexane-ethyl acetate-methanol-water-acetic acid (8...
September 7, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28878762/the-c-terminal-six-amino-acids-of-the-fnt-channel-foca-are-required-for-formate-translocation-but-not-homopentamer-integrity
#2
Doreen Hunger, Marie Röcker, Dörte Falke, Hauke Lilie, R Gary Sawers
FocA is the archetype of the pentameric formate-nitrite transporter (FNT) superfamily of channels, members of which translocate small organic and inorganic anions across the cytoplasmic membrane of microorganisms. The N- and C-termini of each protomer are cytoplasmically oriented. A Y-L-R motif is found immediately after transmembrane helix 6 at the C-terminus of FNT proteins related to FocA, or those with a role in formate translocation. Previous in vivo studies had revealed that formate translocation through FocA was controlled by interaction with the formate-producing glycyl-radical enzyme pyruvate formate-lyase (PflB) or its structural and functional homolog, TdcE...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28843921/a-schiff-base-quaternary-ammonium-salt-bifunctional-graphene-oxide-as-an-efficient-adsorbent-for-removal-of-th-iv-u-vi
#3
Ning Pan, Long Li, Jie Ding, Ruibing Wang, Yongdong Jin, Chuanqin Xia
A novel approach for facile covalent functionalization of graphene oxide (GO) was proposed in the present study in order to effectively avoid necessary anhydrous conditions and the usage of harsh reagents during the chemical functionalization of GO. Herein, a GO derivative that was functionalized with a primary amine derivative bearing a positively charged quaternary ammonium group, GO-S, was synthesized through a Schiff base condensation reaction between the amine groups of the primary amine derivative and the aldehyde groups of GO...
August 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28821360/development-and-implementation-of-an-early-mobility-program-for-mechanically-ventilated-pediatric-patients
#4
Kristina A Betters, Kiran B Hebbar, David Farthing, Brittany Griego, Tricia Easley, Hartley Turman, Lauren Perrino, Stephanie Sparacino, Mary L deAlmeida
PURPOSE: Early mobility (EM) is being used in adult ICUs in an effort to treat and prevent intensive care unit acquired weakness (ICU-AW) and Post-Intensive Care Syndrome (PICS). Data supports children suffer from ICU-AW and PICS as well. Our objective was to create and implement an EM protocol for pediatric patients receiving invasive mechanical ventilation. METHODS: A multidisciplinary EM committee was formed to create and implement an EM protocol in a quarternary care PICU...
August 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28777541/uv-curable-contact-active-benzophenone-terminated-quaternary-ammonium-antimicrobials-for-applications-in-polymer-plastics-and-related-devices
#5
Lukas Porosa, Alexander Caschera, Joseph Bedard, Amanda Mocella, Evan Ronan, Alan J Lough, Gideon Wolfaardt, Daniel A Foucher
A series of UV active benzophenone ([C6H5COC6H4-O-(CH2)n-N(+)Me2R][X(-)]; 4, R = C12H25, n = 3, X(-) = Br(-); 5a-c, R = C18H37, n = 3, X(-) = Cl(-), Br(-), I(-); 6a-c, R = C18H37, n = 4, X(-) = Cl(-), Br(-), I(-); 7a-c, R = C18H37, n = 6, X(-) = Cl(-), Br(-), I(-)) terminated C12 and C18 quaternary ammonium salts (QACs) were prepared by thermal or microwave-driven Menshutkin protocols of the appropriate benzophenone alkyl halide (1a-c, 2a-c, 3a-c) with the corresponding dodecyl- or octadecyl N,N-dimethylamine...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28773004/anti-caries-effects-of-dental-adhesives-containing-quaternary-ammonium-methacrylates-with-different-chain-lengths
#6
Qi Han, Bolei Li, Xuedong Zhou, Yang Ge, Suping Wang, Mingyun Li, Biao Ren, Haohao Wang, Keke Zhang, Hockin H K Xu, Xian Peng, Mingye Feng, Michael D Weir, Yu Chen, Lei Cheng
The objectives of this study were to investigate the effects of dental adhesives containing quaternary ammonium methacrylates (QAMs) with different alkyl chain lengths (CL) on ecological caries prevention in vitro. Five QAMs were synthesized with a CL = 3, 6, 9, 12, and 16 and incorporated into adhesives. Micro-tensile bond strength and surface charge density were used to measure the physical properties of the adhesives. The proportion change in three-species biofilms consisting of Streptococcus mutans, Streptococcus sanguinis, and Streptococcus gordonii was tested using the TaqMan real-time polymerase chain reaction...
June 12, 2017: Materials
https://www.readbyqxmd.com/read/28756055/efficacy-of-over-the-scope-clips-in-management-of-high-risk-gastrointestinal-bleeding
#7
Justin Brandler, Navtej Buttar, Anushka Baruah, Muhammad Zeb, Ayesha Mehfooz, Prachi Pophali, Louis Wong Kee Song, Barham AbuDayyeh, Christopher Gostout, Kristin Mara, Ross Dierkhising
BACKGROUND & AIMS: Standard endoscopic therapies do not control bleeding or produce complications in as many as 20% of patients with non-variceal gastrointestinal bleeding. Most bleeding comes from ulcers with characteristics such as high-risk vascular territories and/or large vessels. We evaluated the efficacy of using over the scope clips (OTSCs) as primary or rescue therapy for patients with bleeding from lesions that have a high-risk for adverse outcomes. METHODS: We performed a retrospective analysis of data from 67 patients with gastrointestinal bleeding from high-risk lesions who were treated with OTSC as primary (n=49) or rescue therapy (n=18) at a quaternary center, from December 2011 through February 2015...
July 26, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28755761/do-quaternary-ammonium-monomers-induce-drug-resistance-in-cariogenic-endodontic-and-periodontal-bacterial-species
#8
Suping Wang, Haohao Wang, Biao Ren, Hao Li, Michael D Weir, Xuedong Zhou, Thomas W Oates, Lei Cheng, Hockin H K Xu
OBJECTIVES: Antibacterial monomers were developed to combat oral biofilm acids and caries; however, little is known on whether quaternary ammonium monomers (QAMs) would induce drug resistance in oral bacteria. The objective of this study was to investigate the effects of new antimicrobial monomers dimethylaminohexadecyl methacrylate (DMAHDM) and dimethylaminododecyl methacrylate (DMADDM) on the induction of drug resistance in eight species of cariogenic, endodontic and periodontal bacteria for the first time...
July 26, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28721420/adsorption-of-galloyl-catechin-aggregates-significantly-modulates-membrane-mechanics-in-the-absence-of-biochemical-cues
#9
Takahisa Matsuzaki, Hiroaki Ito, Veronika Chevyreva, Ali Makky, Stefan Kaufmann, Kazuki Okano, Naritaka Kobayashi, Masami Suganuma, Seiichiro Nakabayashi, Hiroshi Y Yoshikawa, Motomu Tanaka
Physical interactions of four major green tea catechin derivatives with cell membrane models were systemically investigated. Catechins with the galloyl moiety caused the aggregation of small unilamellar vesicles and an increase in the surface pressure of lipid monolayers, while those without did not. Differential scanning calorimetry revealed that, in a low concentration regime (≤10 μM), catechin molecules are not significantly incorporated into the hydrophobic core of lipid membranes as substitutional impurities...
July 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28707340/removal-of-a-consensus-proline-is-not-sufficient-to-allow-tetratricopeptide-repeat-oligomerization
#10
Amber L Bakkum, R Blake Hill
Tetratricopeptide repeat (TPR) domains are ubiquitous protein interaction domains that adopt a modular antiparallel array of α-helices. The TPR fold typically adopts a monomeric state, and consensus TPRs sequences successfully fold into the expected monomeric topology. The versatility of the TPR fold also supports different quaternary structures, which may function as regulatory switches. One example is yeast mitochondrial fission 1 (Fis1) that appears to interconvert between monomer and dimer states in regulating division of peroxisomes and mitochondria...
July 13, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28699164/novel-amino-acid-based-surfactant-for-silicone-emulsification-and-its-application-in-hair-care-products-a-promising-alternative-to-quaternary-ammonium-cationic-surfactants
#11
M Fujii, M Inoue, T Fukami
OBJECTIVE: Quaternary ammonium cationic surfactants (ACSs) and N-[3-alkyl(12,14)oxy-2-hydroxypropyl]-l-arginine hydrochloride (N-AOHPA) were used to emulsify silicone. The potential of the resulting emulsions in hair conditioning products was investigated. METHODS: The emulsions were prepared using a homogenizer and/or high-pressure homogenizer. ACSs and N-AOHPA were used as silicone emulsifiers. The stability of the emulsions was evaluated by measuring particle sizes, creaming fractions, polydispersity indexes and zeta potentials...
October 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28682555/-progress-on-matrix-metalloproteinase-inhibitors
#12
Jia Lingling, Wan Qianbing
Continuing advances in dentin bonding technology and adhesives revolutionized bonding of resin-based composite restorations. However, hybrid layers created by contemporary dentin adhesives present imperfect durability, and degradation of collagen matrix by endogenous enzymes is a significant factor causing destruction of hybrid layers. Bond durability can be improved by using enzyme inhibitors to prevent collagen degradation and to preserve integrity of collagen matrix. This review summarizes progress on matrix metalloproteinase inhibitors (including chlorhexidine, ethylenediaminetetraacetic acid, quaternary ammonium salt, tetracycline and its derivatives, hydroxamic acid inhibitors, bisphosphonate derivative, and cross-linking agents) and suggests prospects for these compounds...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28608873/prediction-of-the-glass-transition-temperature-and-design-of-phase-diagrams-of-butadiene-rubber-and-styrene-butadiene-rubber-via-molecular-dynamics-simulations
#13
Myung Shin Ryu, Hyoung Gyu Kim, Hyun You Kim, Kyung-Shin Min, Hak Joo Kim, Hyuck Mo Lee
To prevent car accidents, it is important to evaluate the thermal stability of tire rubbers, such as natural rubber (NR), butadiene rubber (BR), and styrene-butadiene rubber (SBR). Controlling the glass transition temperature (Tg) is the main factor for obtaining desirable thermal stability. Here, we developed an optimized equation for the prediction of the Tg of the various rubber systems using molecular dynamics (MD) simulations. We modeled a random copolymer system, blended monomers, and calculated the Tg of butadiene isomers in each composition...
June 28, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28604259/reduced-susceptibility-to-antiseptics-is-conferred-by-heterologous-housekeeping-genes
#14
Supathep Tansirichaiya, Liam J Reynolds, Gianmarco Cristarella, Li Chin Wong, Kimie Rosendahl, Adam P Roberts
Antimicrobial resistance is common in the microbial inhabitants of the human oral cavity. Antimicrobials are commonly encountered by oral microbes as they are present in our diet, both naturally and anthropogenically, and also used in oral healthcare products and amalgam fillings. We aimed to determine the presence of genes in the oral microbiome conferring reduced susceptibility to common antimicrobials. From an Escherichia coli library, 12,277 clones were screened and ten clones with reduced susceptibility to triclosan were identified...
June 12, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28579540/a-multi-defense-strategy-enhancing-bactericidal-activity-of-a-medical-grade-polymer-with-a-nitric-oxide-donor-and-surface-immobilized-quaternary-ammonium-compound
#15
Jitendra Pant, Jing Gao, Marcus J Goudie, Sean P Hopkins, Jason Locklin, Hitesh Handa
Although the use of biomedical devices in hospital-based care is inevitable, unfortunately, it is also one of the leading causes of the nosocomial infections, and thus demands development of novel antimicrobial materials for medical device fabrication. In the current study, a multi-defense mechanism against Gram-positive and Gram-negative bacteria is demonstrated by combining a nitric oxide (NO) releasing agent with a quaternary ammonium antimicrobial that can be covalently grafted to medical devices. Antibacterial polymeric composites were fabricated by incorporating an NO donor, S-nitroso-N-acetyl-penicillamine (SNAP) in CarboSil® polymer and top coated with surface immobilized benzophenone based quaternary ammonium antimicrobial (BPAM) small molecule...
June 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28575064/antimicrobial-resistance-of-klebsiella-pneumoniae-stool-isolates-circulating-in-kenya
#16
Chris Rowe Taitt, Tomasz A Leski, Daniel P Erwin, Elizabeth A Odundo, Nancy C Kipkemoi, Janet N Ndonye, Ronald K Kirera, Abigael N Ombogo, Judd L Walson, Patricia B Pavlinac, Christine Hulseberg, Gary J Vora
We sought to determine the genetic and phenotypic antimicrobial resistance (AMR) profiles of commensal Klebsiella spp. circulating in Kenya by testing human stool isolates of 87 K. pneumoniae and three K. oxytoca collected at eight locations. Over one-third of the isolates were resistant to ≥3 categories of antimicrobials and were considered multidrug-resistant (MDR). We then compared the resistance phenotype to the presence/absence of 238 AMR genes determined by a broad-spectrum microarray and PCR. Forty-six genes/gene families were identified conferring resistance to β-lactams (ampC/blaDHA, blaCMY/LAT, blaLEN-1, blaOKP-A/OKP-B1, blaOXA-1-like family, blaOXY-1, blaSHV, blaTEM, blaCTX-M-1 and blaCTX-M-2 families), aminoglycosides (aac(3)-III, aac(6)-Ib, aad(A1/A2), aad(A4), aph(AI), aph3/str(A), aph6/str(B), and rmtB), macrolides (mac(A), mac(B), mph(A)/mph(K)), tetracyclines (tet(A), tet(B), tet(D), tet(G)), ansamycins (arr), phenicols (catA1/cat4, floR, cmlA, cmr), fluoroquinolones (qnrS), quaternary amines (qacEΔ1), streptothricin (sat2), sulfonamides (sul1, sul2, sul3), and diaminopyrimidines (dfrA1, dfrA5, dfrA7, dfrA8, dfrA12, dfrA13/21/22/23 family, dfrA14, dfrA15, dfrA16, dfrA17)...
2017: PloS One
https://www.readbyqxmd.com/read/28566379/discovery-and-mechanistic-study-of-benzamide-derivatives-that-modulate-hepatitis-b-virus-capsid-assembly
#17
Shuo Wu, Qiong Zhao, Pinghu Zhang, John Kulp, Lydia Hu, Nicky Hwang, Jiming Zhang, Timothy M Block, Xiaodong Xu, Yanming Du, Jinhong Chang, Ju-Tao Guo
Chronic hepatitis B virus (HBV) infection is a global public health problem. Although the currently approved medications can reliably reduce the viral load and prevent the progression of liver diseases, they fail to cure the viral infection. In an effort toward discovery of novel antiviral agents against HBV, a group of benzamide (BA) derivatives that significantly reduced the amount of cytoplasmic HBV DNA were discovered. The initial lead optimization efforts identified two BA derivatives with improved antiviral activity for further mechanistic studies...
August 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28518173/simultaneous-quantification-of-n-and-o-glycans-using-a-solid-phase-method
#18
Shuang Yang, Yingwei Hu, Lori Sokoll, Hui Zhang
Glycosylation has a pivotal role in a diverse range of biological activities, modulating the structure and function of proteins. Glycogens coupled to the nitrogen atom (N-linked) of asparagine side chains or to the oxygen atom (O-linked) of serine and threonine side chains represent the two major protein glycosylation forms. N-glycans can be released by glycosidases, whereas O-glycans are often cleaved by chemical reaction. However, it is challenging to combine these enzymatic and chemical reactions in order to analyze both N- and O-glycans...
June 2017: Nature Protocols
https://www.readbyqxmd.com/read/28427352/point-of-sampling-detection-of-zika-virus-within-a-multiplexed-kit-capable-of-detecting-dengue-and-chikungunya
#19
Ozlem Yaren, Barry W Alto, Priyanka V Gangodkar, Shatakshi R Ranade, Kunal N Patil, Kevin M Bradley, Zunyi Yang, Nikhil Phadke, Steven A Benner
BACKGROUND: Zika, dengue, and chikungunya are three mosquito-borne viruses having overlapping transmission vectors. They cause diseases having similar symptoms in human patients, but requiring different immediate management steps. Therefore, rapid (< one hour) discrimination of these three viruses in patient samples and trapped mosquitoes is needed. The need for speed precludes any assay that requires complex up-front sample preparation, such as extraction of nucleic acids from the sample...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28422757/cross-reactive-dengue-human-monoclonal-antibody-prevents-severe-pathologies-and-death-from-zika-virus-infections
#20
Yiu-Wing Kam, Cheryl Yi-Pin Lee, Teck-Hui Teo, Shanshan W Howland, Siti Naqiah Amrun, Fok-Moon Lum, Peter See, Nicholas Qing-Rong Kng, Roland G Huber, Mei-Hui Xu, Heng-Liang Tan, Andre Choo, Sebastian Maurer-Stroh, Florent Ginhoux, Katja Fink, Cheng-I Wang, Lisa F P Ng, Laurent Rénia
Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. Given the high level of homology between ZIKV and the related flavivirus dengue virus (DENV), we investigated the level of cross-reactivity with ZIKV using a panel of DENV human mAbs. A majority of the mAbs showed binding to ZIKV virions, with several exhibiting neutralizing capacities against ZIKV in vitro. Three of the best ZIKV-neutralizing mAbs were found to recognize diverse epitopes on the envelope (E) glycoprotein: the highly conserved fusion-loop peptide, a conformation-specific epitope on the E monomer, and a quaternary epitope on the virion surface...
April 20, 2017: JCI Insight
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