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Fusarium in childrens

Isabel Barranco-Fernández, Alberto García-Salido, Montserrat Nieto-Moro, Montserrat Sierra-Colomina, Belén Gutierrez-Partida, Inmaculada de Prada-Vicente, Antonio Torrelo-Fernández, Ana Serrano-González
Fusarium species are a known cause of ocular infection. The misuse of contact lenses is the main risk factor in immunocompetent people. In immunocompromised patients, Fusarium infection can produce local and/or systemic invasive fusariosis which is associated with complications, poor prognosis and low response to treatment.Fusarium ocular infection can evolve to keratitis, endophthalmitis and, in extreme cases, ocular perforation. We report, for the first time in children, the case of a 5 year old girl diagnosed with toxic epidermal necrolysis who developed Fusarium ocular infection requiring ocular enucleation...
October 12, 2016: Pediatric Infectious Disease Journal
Kathleen M Job, Jared Olson, Chris Stockmann, Jonathan E Constance, Elena Y Enioutina, Joseph E Rower, Matthew W Linakis, Alfred H Balch, Tian Yu, Xiaoxi Liu, Emily A Thorell, Catherine M T Sherwin
INTRODUCTION: Voriconazole is a broad-spectrum antifungal agent commonly used to treat invasive fungal infections (IFI), including aspergillosis, candidiasis, Scedosporium infection, and Fusarium infection. IFI often occur in immunocompromised patients, leading to increased morbidity and mortality. AREAS COVERED: The objective of this review is to summarize the pharmacodynamic properties of voriconazole and to provide considerations for potential optimal dosing strategies...
August 2016: Expert Review of Anti-infective Therapy
C Wiegand, P Mugisha, G K Mulyowa, P Elsner, U C Hipler, Y Gräser, S Uhrlaß, P Nenoff
BACKGROUND: Tinea capitis is caused by anthropophilic, zoophilic or geophilic dermatophytes of the genera Microsporum or Trichophyton. OBJECTIVE: The aim of this study was to analyze the clinical presentation of tinea capitis among children in western Uganda. PATIENTS AND METHODS: From February to June 2012, skin and hair samples were obtained from 115 patients aged from 1 to 16 years presenting at Mbarara Regional Referral Hospital (MUSC) with clinically suspected tinea capitis...
September 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Aaron Campigotto, Susan E Richardson, Michael Sebert, Erin McElvania TeKippe, Aparna Chakravarty, Christopher D Doern
The use of the Wampole Isolator 1.5-ml pediatric blood culture tube for the detection of fungemia in children was assessed by a 10-year retrospective review at two pediatric hospitals, The Hospital for Sick Children in Toronto, Canada, and the Children's Medical Center of Dallas, Texas. Over this period, a total of 9,442 pediatric Isolator specimens were processed, with yeast or yeast-like organisms recovered in 297 (3.1%) of the specimens (151 [1.6%] unique clinical episodes) and filamentous or dimorphic fungi recovered in 31 (0...
September 2016: Journal of Clinical Microbiology
Geusa Felipa de Barros Bezerra, Denise Maria Costa Haidar, Marcos Antonio Custódio Neto da Silva, Walbert Edson Muniz Filho, Ramon Moura Dos Santos, Ivone Garros Rosa, Graça Maria de Castro Viana, Luís Zaror, Maria do Desterro Soares Brandão Nascimento
BACKGROUND: To evaluate total and specific E immunoglobulin (IgE) antibody concentrations in underage subjects with respiratory allergic diseases. METHODS: This study was a transversal-type study in 100 underage subjects between 4 and 14 years old, with asthma and/or allergic rhinitis. Total and specific IgE were quantified for airborne fungi in the city of São Luís, Maranhão, Brazil. Five distinct regions-North, South, Center, East and West-were selected so fungi could be collected monthly for 1 year...
2016: Allergy, Asthma, and Clinical Immunology
Lokeshwari Aruljyothi, Naveen Radhakrishnan, Venkatesh N Prajna, Prajna Lalitha
PURPOSE: To study the risk factors, microbiological profile and clinical outcomes of infectious keratitis affecting paediatric patients. STUDY DESIGN: Retrospective case series. METHODS: Review of case records of paediatric patients (0-16 years) diagnosed with infectious keratitis who presented to Aravind Eye Hospital, Madurai, India during January 2011 to December 2013. Demographic details, predisposing factors, microbiological investigations, clinical course and visual outcome were analysed...
February 25, 2016: British Journal of Ophthalmology
Kevin L Schwartz, Holden Sheffield, Susan E Richardson, Lillian Sung, Shaun K Morris
Invasive fungal infection (IFI) is an important cause of mortality in immunocompromised children, particularly after hematopoietic stem cell transplantation. We describe 5 cases of Fusarium IFI in immunocompromised children seen at our institution over a 15-year period. A summary of all published pediatric cases of invasive Fusarium infection is presented. A focus on antifungal management challenges in these patients will be discussed.
June 2015: Journal of the Pediatric Infectious Diseases Society
J Kumi, N J Mitchell, G A Asare, E Dotse, F Kwaa, T D Phillips, N-A Ankrah
BACKGROUND: Weanimix is an important food for children in Ghana. Mothers are trained to prepare homemade weanimix from beans, groundnuts and maize for their infants. Groundnuts and maize are prone to aflatoxin contamination while fumonisin contaminates maize. Aflatoxin, is produced by the Asperguillus fungi while fumonisin, is produced by Fusarium fungi. These mycotoxins occur in tropical areas worldwide due to favorable climate for their growth. OBJECTIVE: The objective of the study was to determine the levels of aflatoxin and fumonisin in homemade weanimix in the Ejura-Sekyedumase district in the Ashanti Region of Ghana...
September 2014: Ghana Medical Journal
Nadia Litvinov, Mariama Tomaz N da Silva, Inneke M van der Heijden, Mariana G Graça, Larissa Marques de Oliveira, Liang Fu, Mauro Giudice, Maria Zilda de Aquino, Vicente Odone-Filho, Heloisa Helena Marques, Silvia F Costa, Anna S Levin
Fusarium is considered an emerging pathogen, and there are few reports of fusariosis in children. The objective of this study was to describe an outbreak of invasive fusariosis in a children's cancer hospital. A neutropenic 17-year-old male patient hospitalized for 10 days for a relapse of acute myeloid leukaemia, under chemotherapy, presented fever without any other symptoms; a thoracic computerized tomography showed bilateral pulmonary nodules. During voriconazole treatment, 1-cm reddened and painful subcutaneous nodules appeared on arms and legs and the culture of a skin biopsy revealed F...
March 2015: Clinical Microbiology and Infection
Dhanashree Ratra, Shafiq Jafferji, Jyotirmay Biswas
PURPOSE: To report a case of unilateral postsurgical bacterial endophthalmitis, which presented in an unusual manner with frosted branch angiitis. METHODS: We reviewed the chart of a patient with acute postoperative bacterial endophthalmitis who presented initially as frosted branch angiitis and subsequently developed full-fledged endophthalmitis. RESULTS: The patient was treated with conventional treatment for postsurgical endophthalmitis along with oral steroids...
2010: Retinal Cases & Brief Reports
C Brera, F Debegnach, B De Santis, S Di Ianni, E Gregori, S Neuhold, F Valitutti
Mycotoxins are low molecular weight secondary metabolites produced by certain strains of filamentous fungi such as Aspergillus, Penicillium and Fusarium, which attack crops in the field, and grow on foods also during storage under favorable conditions of temperature and humidity. Foods mainly contributing to the intake of mycotoxins with diet are cereals, maize being the most risky commodity due to the potential co-occurrence of more than one mycotoxin, this can be of particular concern especially for vulnerable group of population such as celiac patients that show increased maize-based products consumption...
July 2014: Food and Chemical Toxicology
Shaun K Morris, Upton D Allen, Sumit Gupta, Susan E Richardson
BACKGROUND: Caspofungin is an echinocandin class antifungal medication that is commonly used empirically in immunocompromised patients at high risk for invasive fungal disease. OBJECTIVE: To describe the clinical characteristics of breakthrough fungal infections in pediatric hematopoetic stem cell transplant recipients, and oncology and hematology patients receiving caspofungin. METHODS: A five-year retrospective review, from 2004 through 2008, of all cases of proven invasive filamentous fungal infection of children admitted to The Hospital for Sick Children (Toronto, Ontario) was conducted...
2012: Canadian Journal of Infectious Diseases & Medical Microbiology
Maria Giannaki, Talia Kakourou, Maria Theodoridou, Vassiliki Syriopoulou, Marios Kabouris, Eirini Louizou, George Chrousos
The human papillomavirus (HPV) infects the squamous epithelium of the skin and produces common warts, plantar warts, and flat warts, which occur commonly on the hands, face, and feet. The objective of this study was to determine the presence of HPV in warts in children in order to associate the virus with the disease. Sixty-eight children with clinically diagnosed cutaneous warts were recruited. Skin biopsy samples were examined and DNA was extracted using a commercially available kit. To distinguish between the HPV types, we used a specific pair of primers to amplify the HPV DNA...
November 2013: Pediatric Dermatology
Yelko Rodríguez-Carrasco, María José Ruiz, Guillermina Font, Houda Berrada
Mycotoxins are harmful substances produced by fungi in several commodities with a widespread presence in foodstuffs. Human exposure to mycotoxins occurs mainly by contaminated food. The quantitation of mycotoxins in cereal-based food, highly consumed by different age population, is of concern. In this survey, 159 cereal-based samples classified as wheat, maize and rice-based, have been evaluated for the occurrence of patulin, deoxynivalenol, 3-acetyl-deoxynivalenol, fusarenon-X, diacetoxyscirpenol, nivalenol, neosolaniol, HT-2, T-2 and zearalenone by gas chromatography-tandem mass spectrometry...
November 2013: Chemosphere
Keyvan Pakshir, Moosa Rahimi Ghiasi, Kamiar Zomorodian, Ali Reza Gharavi
INTRODUCTION: Keratinophilic fungi are an important group of fungi that live in soil. The aim of this study was to isolate and identify keratinophilic fungi from the soil of different parks in Shiraz. MATERIALS AND METHODS: A total of 196 soil samples from 43 parks were collected. Isolation of the fungi was performed by hair bait technique. The isolated colonies were identified by morphologic feature of macro- and microconidia and molecular method, using DNA sequence analysis...
2013: BioMed Research International
Saurabh Garge, Monika Bawa, Ravi P Kanojia, Kirti Gupta, Kattragadda Laxmi Narain Rao
Adrenocortical carcinoma (ACC) is a rare malignancy in children. Most of these are endocrinologically active tumors, with virilizing features being typically dominant. Its presentation with isolated Cushing syndrome is rare. We report a 3-month-old infant with Cushing syndrome without the clinical features of androgen or mineralocorticoid excess consequently diagnosed with ACC. We discuss the different presentations, diagnosis, and management of this rare tumor with a rarer presentation.
2013: Journal of Pediatric Endocrinology & Metabolism: JPEM
Joanna Blaszkowska, Anna Wojcik, Piotr Kurnatowski, Katarzyna Szwabe
The in vitro effect of saprotrophic soil fungi on the embryonic development of Ascaris suum was evaluated. The fungi tested were Aspergillus fumigatus, Aspergillus terreus, Penicillium citrinum, Penicillium expansum, Fusarium oxysporum and Trichothecium roseum, isolated from children's recreation areas in the city of Lodz (Poland). Each species was co-cultured with A. suum egg suspension (6 × 10(3)eggs/ml) at 25 ± 2°C for 60 days. Each day, 100 eggs were randomly collected and their developmental stage was classified macroscopically...
September 23, 2013: Veterinary Parasitology
Ana-Marija Domijan
Fumonisin B(1) (FB(1)) is a mycotoxin produced by Fusarium spp. moulds that contaminate crop, predominantly maize, all around the world. More than 15 types of fumonisins have been indentified so far, but FB(1) is the most abundant and toxicologically the most significant one. FB(1) has a wide range of toxic effects, depending on animal species. In horses FB(1) causes equine leukoencephalomalacia (ELEM), in pigs pulmonary oedema and in experimental rodents nephrotoxicity and hepatotoxicity. In humans exposure to FB(1) is linked with higher incidence of primary liver cancer and oesophageal cancer, which are frequent in certain regions of the world (such as Transkei region in South Africa) where maize is staple food...
December 2012: Arhiv za Higijenu Rada i Toksikologiju
Habibe Ovet, Cağrı Ergin, Ilknur Kaleli
Atmospheric fungal spores play important role in allergic reactions in atopic individuals. Monitorization of those spores found in the environment of atopic cases is crucial for the choice of the antigens that will be included in allergen screening procedures and precautions to be taken against mold-originated health problems. Since most of the people spend plenty of time indoors in recent years, the effects of exposure to indoor air fungi on human health have gained importance. This study was aimed to investigate the indoor air mold distribution of elementary schools in Denizli province (located in west Anatolia, Turkey) and to compare the allergen-specific IgE levels of children against the most frequently detected mold genus...
April 2012: Mikrobiyoloji Bülteni
Laurel A Leithauser, Diya F Mutasim
Pemphigus herpetiformis (PH) is a rare autoimmune vesiculobullous disease. It clinically mimics dermatitis herpetiformis and has immunofluorescent findings typical of pemphigus. PH occurs in adults more commonly than children and is often effectively treated with dapsone. We report a case of PH occurring in a 9-year-old boy that was refractory to dapsone and to various other steroid-sparing medications but resolved with methotrexate.
November 2013: Pediatric Dermatology
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