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https://www.readbyqxmd.com/read/27893468/linear-folliculotropic-cd30-positive-lymphomatoid-drug-reaction
#1
Yi-Chin Chen, Yu-Hung Wu
We report a unique case of probable drug-induced CD30-positive lymphomatoid reaction. A 58-year-old woman presented with bilateral facial eruptions of 3 weeks duration composed of erythematosus papules in a linear distribution. The pathological features demonstrated a dense dermal and follicular infiltrate of many medium- to large-sized atypical CD30-positive lymphoid cells. The rash resolved rapidly after discontinuation of her medication 1 week later and did not recur. This case highlights the importance of clinicopathological correlation...
November 22, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27893466/cd30-expression-is-rare-in-myeloid-leukemia-cutis-a-study-of-55-cases-and-implications-for-routine-diagnostic-algorithms
#2
Olakunle Ogunrinade, David Terrano, April Chiu, Melissa Pulitzer
Expression of CD30 in blastoid cutaneous infiltrates typically signifies a CD30 lymphoproliferative disorder, often requiring minimal immunohistochemical workup, if clinically consonant. However, myeloid and other hematologic malignancies often express CD30. We retrospectively examined the prevalence of CD30 expression in 41 patients (median age 59) and 55 biopsies with the diagnosis of leukemia cutis (LC) to determine whether an extensive immunohistochemical workup is warranted in all large, round cell CD30 cutaneous infiltrates...
November 22, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27888664/ebv-associated-but-hhv8-unrelated-double-hit-effusion-based-lymphoma
#3
Bo-Jung Chen, David Yen-Ting Chen, Chun-Chi Kuo, Shih-Sung Chuang
Effusion-based lymphoma is a rare and unique type of large B-cell lymphoma presenting in effusion without a mass lesion. It shares many clinicopathological features with primary effusion lymphoma (PEL), but is distinct from PEL by the absence of HHV8 association. Double hit lymphoma (DHL) is an aggressive B-cell lymphoma, defined by concurrent rearrangement of MYC and BCL2 or BCL6. DHL often presents as lymphadenopathy or an extranodal mass, but rarely occurs in effusion. Here we report a 61-year-old male with alcoholic cirrhosis presenting as massive ascites and left pleural effusion...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27879514/primary-cutaneous-t-cell-lymphomas-showing-gamma-delta-%C3%AE-%C3%AE-phenotype-and-predominantly-epidermotropic-pattern-are-clinicopathologically-distinct-from-classic-primary-cutaneous-%C3%AE-%C3%AE-t-cell-lymphomas
#4
E Dean Merrill, Rose Agbay, Roberto N Miranda, Phyu P Aung, Michael T Tetzlaff, Ken H Young, Jonathan L Curry, Priyadharsini Nagarajan, Doina Ivan, Victor G Prieto, L Jeffrey Medeiros, Madeleine Duvic, Carlos A Torres-Cabala
Primary cutaneous gamma-delta (γδ) T-cell lymphoma is a rare disease that typically involves the dermis and subcutis. Cases of primary cutaneous T-cell lymphomas showing γδ phenotype and predominantly epidermotropic pattern (EγδTCL) are not well defined. In this series, cases of primary cutaneous T-cell lymphomas showing γδ phenotype were reviewed and classified as predominantly epidermotropic (EγδTCL) when >75% of lymphoma cells resided in the epidermis or predominantly dermal and/or subcutaneous (DSγδTCL)...
November 22, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27874877/low-dose-radiotherapy-for-primary-cutaneous-anaplastic-large-cell-lymphoma-while-on-low-dose-methotrexate
#5
Christine M Cornejo, Roberto A Novoa, Robert E Krisch, Ellen J Kim
Primary cutaneous anaplastic large-cell lymphoma (pcALCL) is part of a spectrum of CD30+ primary cutaneous lymphoproliferative disorders (pcLPDs) that also includes lymphomatoid papulosis (LyP). Localized radiotherapy at doses of 34 to 44 Gy is first-line treatment of pcALCL, but the use of low-dose radiotherapy for pcALCL has not been reported. We present the case of a patient with a history of pcALCL/LyP who was treated with low-dose radiotherapy while on oral low-dose methotrexate (MTX) once weekly. This report suggests that low-dose radiotherapy can be an effective palliative treatment of pcALCL...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27870927/cd30-induces-heat-shock-protein-90-and-signal-integration-in-classic-hodgkin-lymphoma-cells
#6
Mariko Watanabe, Kazumi Nakano, Marshall E Kadin, Masaaki Higashihara, Toshiki Watanabe, Ryouichi Horie
Previous studies report deregulation of multiple signaling pathways in classic Hodgkin lymphoma (cHL) cells. However, the mechanisms of how these pathways are integrated are not fully understood. Herein, we show involvement of cHL hallmark antigen CD30 in this process. CD30 facilitates phosphorylation of heat shock factor 1, activates heat shock promoter element, and induces heat shock protein (HSP) 90. CD30 repression and subsequent inhibition of HSP90 suppresses NF-κB, extracellular signal-regulated kinase, AKT, and STAT pathways in cHL cell lines...
November 18, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27868471/brentuximab-vedotin-activity-in-diffuse-large-b-cell-lymphoma-with-cd30-undetectable-by-visual-assessment-of-conventional-immunohistochemistry
#7
Nancy L Bartlett, Mitchell R Smith, Tanya Siddiqi, Ranjana H Advani, Owen A O'Connor, Jeff P Sharman, Tatyana Feldman, Kerry J Savage, Andrei R Shustov, Catherine S Diefenbach, Yasuhiro Oki, Maria Corinna Palanca-Wessels, Mayur Uttarwar, Martha Li, Jing Yang, Eric D Jacobsen
This phase 2 study evaluated brentuximab vedotin monotherapy in CD30-expressing DLBCL; after several patients with little to no CD30 achieved a complete remission (CR), the study evaluated treatment of DLBCL with undetectable CD30 (CD30u) by local visual immunohistochemistry (vIHC). Sixteen of 52 CD30u DLBCL patients (31%) had an objective response (6 CRs [12%]). Median progression-free survival (PFS) was 1.4 months (range, 0.4-15.6) and median overall survival (OS) was 7.5 months (range, 0.7-18.6+). Subsequent CD30 expression quantitated by computer-assisted digital image analysis (cIHC) showed that 11 of 16 CD30u DLBCL responders had ≥1% CD30...
November 20, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27868293/clinical-features-of-diffuse-large-b-cell-lymphoma-with-polyploidy
#8
Joji Shimono, Hiroaki Miyoshi, Masao Seto, Takanori Teshima, Koichi Ohshima
Polyploidy, defined as more than two sets of homologous chromosomes, is found in a variety of malignant tumors and is thought to be related to disease pathogenesis. However, there have been no studies that have investigated polyploidy in diffuse large B-cell lymphoma (DLBCL). Here we reviewed clinicopathological features of 16 cases of DLBCL with polypoidy, which was defined as DLBCL with either near-tetraploid or greater number of chromosomes as detected by the G-band method. The frequency of polyploid DLBCL was 2...
November 21, 2016: Pathology International
https://www.readbyqxmd.com/read/27864829/pediatric-case-of-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-forming-a-solitary-skin-tumor-on-the-forearm
#9
Michio Tokuyama, Yuta Kurashige, Tami Ota, Yasuaki Manabe, Hanako Yamaoka, Norihiro Ikoma, Akiko Fukumura, Michie Miyashita, Keisuke Otsubo, Tsuyoshi Morimoto, Hiroyuki Mochizuki, Natsuko Nakano, Naoya Nakamura, Akira Ozawa, Tomotaka Mabuchi
A 5-year-old girl noticed a rapidly growing reddish nodule on her right forearm. Although oral antibiotics had been administrated for 2 weeks, the tumor enlarged. Skin biopsy revealed excessive infiltration of atypical neoplastic cells expressing CD4, CD30 and anaplastic lymphoma kinase (ALK). These histological and immunohistochemical findings were consistent with anaplastic large cell lymphoma (ALCL). Computed tomography showed multiple lymphadenopathy, but lymph node biopsy and bone marrow examination did not show any evidence of systemic dissemination...
November 18, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27847082/slow-growing-mediastinal-grey-zone-lymphoma-originating-from-a-formerly-resected-multilocular-thymic-cyst
#10
Rie Tabata, Chiharu Tabata, Yoshitane Tsukamoto, Masaki Hashimoto, Ryoji Yasumizu, Masaru Kojima
We report a unique case of mediastinal grey zone lymphoma that was considered to originate from CD20(+)CD30(+) Hodgkin cell-like cells associated with a multilocular thymic cyst that had been completely removed 4 years previously. In the formerly resected thymus, irregular-shaped cysts were observed, and large CD20(+)CD30(+) Hodgkin cell-like cells proliferated in close association with the proliferating thymic epithelial cells. This case suggests the important role of thymic columnar epithelial cells in the proliferation of thymic B cells and the tumorigenesis of mediastinal grey zone lymphoma...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27844106/lymphoma-current-status-of-clinical-and-preclinical-imaging-with-radiolabeled-antibodies
#11
REVIEW
Christopher G England, Lixin Rui, Weibo Cai
Lymphoma is a complex disease that arises from cells of the immune system with an intricate pathology. While lymphoma may be classified as Hodgkin or non-Hodgkin, each type of tumor is genetically and phenotypically different and highly invasive tissue biopsies are the only method to investigate these differences. Noninvasive imaging strategies, such as immunoPET, can provide a vital insight into disease staging, monitoring treatment response in patients, and dose planning in radioimmunotherapy. ImmunoPET imaging with radiolabeled antibody-based tracers may also assist physicians in optimizing treatment strategies and enhancing patient stratification...
November 14, 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27837256/pharmacokinetics-immunogenicity-and-safety-of-weekly-dosing-of-brentuximab-vedotin-in-pediatric-patients-with-hodgkin-lymphoma
#12
Jamie E Flerlage, Monika L Metzger, Jianrong Wu, John C Panetta
PURPOSE: Because of the observed success of phase I/II trials, the novel anti-CD30 agent brentuximab vedotin is now being evaluated as a frontline agent in the high-risk pediatric Hodgkin lymphoma trial HLHR13. The objectives of this study were to evaluate the pharmacokinetic variability during weekly dosing of 1.2 mg/kg of brentuximab vedotin, determine factors that may explain this variability, compare our drug exposure with published data, and evaluate toxicity of brentuximab vedotin in the pediatric population...
November 11, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27824517/a-rare-case-of-orbital-hodgkin-lymphoma-demonstrating-therapeutic-response-to-a-novel-systemic-medication
#13
Brynn N Wajda, Michael P Rabinowitz
Orbital Hodgkin lymphoma is infrequent, representing less than 1% of adult orbital malignancies. It is typically seen in the setting of terminally advanced systemic disease. This case highlights orbital, head, and neck disease in a systemically stable individual treated with the novel anti-CD30 monoclonal antibody brentuximab vedotin.
November 8, 2016: Orbit
https://www.readbyqxmd.com/read/27819494/impact-of-chelators-induced-phytoextraction-of-cadmium-on-yield-and-ionic-uptake-of-maize
#14
Sumera Anwar, Shahbaz Khan, M Yasin Ashraf, Sana Ullah Baloch, Sara Zafar, Ali Noman
Enhanced phytoextraction uses soil chelators to increase the bioavailability of heavy metals. This study tested the effectiveness of ethylenediaminetetraaceticacid (EDTA) and citric acid in enhancing cadmium (Cd) phytoextraction, and their effects on the growth, yield, and ionic uptake of maize (Zea mays). Maize seeds of two cultivars were sown in pots treated with 15 (Cd15) or 30 mg Cd kg(-1) soil (Cd30). EDTA and citric acid at 0.5 g kg(-1) each were applied 2 weeks after germination. Results demonstrated that the growth, yield per plant, and total grain weight was reduced by exposure to Cd...
November 7, 2016: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/27816715/cd30-expression-and-prognostic-significance-in-r-epoch-treated-patients-with-diffuse-large-b-cell-lymphoma
#15
Jie Xu, Yasuhiro Oki, Annapurna Saksena, Parth Desai, Pei Lin, Guilin Tang, C Cameron Yin, M James You, Beenu Thakral, L Jeffrey Medeiros, Shaoying Li
A few recent studies investigated the prognostic impact of CD30 expression in diffuse large B cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. No study has evaluated the significance of CD30 expression in DLBCL patients treated with rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH). In a group of 97 patients with DLBCL and high-risk features who received R-EPOCH induction therapy, we studied CD30 expression by immunohistochemistry using different cutoff values (> 0% and ≥20% of lymphoma cells, respectively) and correlated with prognosis...
November 2, 2016: Human Pathology
https://www.readbyqxmd.com/read/27813134/establishment-and-characterization-of-a-novel-hodgkin-lymphoma-cell-line-am-hlh-carrying-the-epstein-barr-virus-genome-integrated-into-the-host-chromosome
#16
Masahiko Hayashida, Masanori Daibata, Erika Tagami, Takahiro Taguchi, Fumiyo Maekawa, Kayo Takeoka, Katsuhiro Fukutsuka, Daiki Shimomura, Takamasa Hayashi, Yoshinori Iwatani, Hitoshi Ohno
We describe the establishment and characterization of a cell line, AM-HLH, obtained from a patient with Epstein-Barr virus-positive (EBV(+) ) nodular sclerosis-type Hodgkin lymphoma (HL). The cells were positive for CD2 and CD30 and negative for CD15. The immunoglobulin heavy- and κ light-chain genes were rearranged. The karyotype was of the triploid range. Southern blotting using the EBV terminal repeat probe detected 3 hybridizing bands that were identical to those of the parental HL material. The cells expressed EBV-encoded RNAs as well as latent genes (EBNA1, EBNA2, LMP1, and LMP2A) and lytic genes (BZLF1 and BALF2)...
November 4, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27807492/novel-brentuximab-vedotin-combination-therapies-show-promising-activity-in-highly-refractory-cd30-non-hodgkin-lymphoma-a-case-series-and-review-of-the-literature
#17
Wilfred Delacruz, Robert Setlik, Arash Hassantoufighi, Shyam Daya, Susannah Cooper, Dale Selby, Alexander Brown
Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of hematologic malignancies which typically respond to standard first-line chemoimmunotherapy regimens. Unfortunately, patients with refractory NHL face a poor prognosis and represent an unmet need for improved therapeutics. We present two cases of refractory CD30+ NHL who responded to novel brentuximab vedotin- (BV-) based regimens. The first is a patient with stage IV anaplastic large cell lymphoma (ALCL) with cranial nerve involvement who failed front-line treatment with cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP) and second line cyclophosphamide, vincristine, doxorubicin, dexamethasone alternating with high-dose methotrexate (MTX), and cytarabine (hyperCVAD) with intrathecal- (IT-) MTX and IT-cytarabine, but responded when BV was substituted for vincristine (hyperCBAD)...
2016: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/27797254/hepatitis-c-virus-associations-with-non-hodgkin-s-lymphoma-insights-on-in-ammation-angiogenesis-and-cd-markers
#18
Eman A El-Maadawy, Roba M Talaat, Rawia F Sadek, Sherif M El-Sherbini, Naser Abdel-Bary, Amal A Abdel-Aziz
We aimed to investigate any association between hepatitis C virus (HCV) infection and non-Hodgkin's lymphoma (NHL) in the view of cytokines that control in ammation/angiogenesis and their correlation with certain CD markers. NHL patients with or without HCV infection were studied. CD5, CD30, CD3, CD20 and CD45 were immunohistochemically evaluated. Plasma levels of vascular endothelial and platelet derived growth factors (VEGF, and PDGF), tumor necrosis factor (TNF-α), transforming growth factor (TGF-β), interleukin-6 (IL-6), IL-8, IL-4, IL-12 and interferon gamma (IFN-γ) were detected by enzyme-linked immunosorbent assay (ELISA)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27789281/prolonged-lymphocytosis-as-the-first-manifestation-of-hodgkin-like-adult-t-cell-leukemia-lymphoma
#19
Achiléa L Bittencourt, Agnes Carvalho Andrade, Cristiane Requião, Maria da Gloria Bomfim Arruda, Iguaracyra Araújo
Hodgkin-like ATLL is a rare variant of adult T-cell leukemia/lymphoma (ATLL), a disease caused by human T-cell lymphotropic virus type-1 (HTLV-1). At admission, a 46-year-old female presented with lymphadenomegaly, lymphocytosis, slight elevation of LDH blood level, and acid-alcohol resistant bacilli in sputum and was being treated for pulmonary tuberculosis (Tb). She had lymphocytosis in the previous 20 months. Serology for HTLV-1 was positive. Lymph node was infiltrated by medium-sized lymphocytes with scattered Hodgkin and Reed-Sternberg-like cells CD30+, CS1-4+, and CD79a+...
October 24, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27774699/characterization-of-teratogenic-potential-and-gene-expression-in-canine-and-feline-amniotic-membrane-derived-stem-cells
#20
M T Cardoso, A O Pinheiro, A S Vidane, J B Casals, V C de Oliveira, Njn Gonçalves, D S Martins, C E Ambrósio
The biosafety of innovative procedures that utilize stem cells in regenerative medicine has been addressed in several studies. Previous work has showed no tumour formation following the use of feline and human amniotic membrane-derived stem cells (AMSCs). In contrast, tumour formation was observed when canine AMSCs were utilized. These findings suggested that feline and human, but not canine, AMSCs are suitable for cell transplantation trials. This study aimed to further evaluate the feasibility of utilizing canine AMSCs for transplantation purposes as well as for felines...
October 23, 2016: Reproduction in Domestic Animals, Zuchthygiene
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