keyword
MENU ▼
Read by QxMD icon Read
search

Two midnight

keyword
https://www.readbyqxmd.com/read/28505279/somatic-usp8-gene-mutations-are-a-common-cause-of-pediatric-cushing-disease
#1
Fabio R Faucz, Amit Tirosh, Christina Tatsi, Annabel Berthon, Laura C Hernández-Ramírez, Nikolaos Settas, Anna Angelousi, Ricardo Correa, Georgios Z Papadakis, Prashant Chittiboina, Martha Quezado, Nathan Pankratz, John Lane, Aggeliki Dimopoulos, James L Mills, Maya Lodish, Constantine A Stratakis
Context: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have been recently identified as the most common genetic alteration in patients with Cushing disease (CD). However, the frequency of these mutations in the pediatric population has not been extensively assessed. Objective: We investigated the status of the USP8 gene at the somatic level in a cohort of pediatric patients with corticotroph adenomas. Design and Methods: The USP8 gene was fully sequenced in both germline and tumor DNA samples from 42 pediatric CD patients...
May 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28321939/examining-the-sociocultural-sensitivity-of-subjective-drunkenness-comparing-arab-and-jewish-israeli-pub-patrons
#2
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
INTRODUCTION AND AIMS: Subjective drunkenness measures may be useful screening tools for alcohol-related problems. However, if self-reported drunkenness is influenced by social and cultural understandings, the measure may not predict drinking patterns equally across different sociocultural groups. The current study aims to determine whether the two main sociocultural groups in Israel (Arabs and Jews) are equally likely to report drunkenness at comparable levels of breath alcohol content (BrAC)...
March 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28315773/the-time-enzyme-in-melatonin-biosynthesis-in-fish-day-night-expressions-of-three-aralkylamine-n-acetyltransferase-genes-in-three-spined-stickleback
#3
REVIEW
Ewa Kulczykowska, Agnieszka Kleszczyńska, Magdalena Gozdowska, Ewa Sokołowska
In vertebrates, aralkylamine N-acetyltransferase (AANAT; EC 2.3.1.87) is a time-keeping enzyme in melatonin (Mel) biosynthesis. Uniquely in fish, there are several AANAT isozymes belonging to two AANAT subfamilies, AANAT1 and AANAT2, which are encoded by distinct genes. The different substrate preferences, kinetics and spatial expression patterns of isozymes indicate that they may have different functions. In the three-spined stickleback (Gasterosteus aculeatus), there are three genes encoding three AANAT isozymes...
June 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28270041/bleeding-gastric-and-duodenal-ulcers-case-control-study-comparing-angioembolization-and-surgery
#4
Taina Nykänen, Erno Peltola, Leena Kylänpää, Marianne Udd
OBJECTIVES: To compare the safety, efficacy and feasibility of transcatheter arterial embolization (TAE) and surgery in the treatment of bleeding gastric and duodenal ulcers (BGDUs). MATERIALS AND METHODS: The study group comprised patients receiving TAE or surgery for BGDUs after failed endoscopic hemostasis in Helsinki University Hospital (HUH) during 2000-2015. Hospital medical records provided study data. 30-d mortality and rebleeding rates were the primary outcomes...
May 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28220407/favourable-outcome-in-two-pregnancies-in-a-patient-with-3-hydroxy-3-methylglutaryl-coa-lyase-deficiency
#5
David Santosa, Markus G Donner, Stephan Vom Dahl, Markus Fleisch, Thomas Hoehn, Ertan Mayatepek, Katrin Heldt, Tim Niehues, Dieter Häussinger
In patients with 3-hydroxy-3-methylglutaryl(HMG)-CoA lyase deficiency (OMIM 246450), five pregnancies have been described worldwide, which were either terminated or resulted in severe metabolic sequelae during pregnancy or delivery. Here, we report on a patient with HMG-CoA lyase deficiency, who underwent two uncomplicated pregnancies. The 19-year-old patient was admitted because of recurrent vomiting and nausea. Diagnostics revealed pregnancy at week 8 of gestation. Metabolic analyses revealed normal lactate and blood glucose levels and normal acid-base status...
February 21, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28178327/characterization-of-ghrelin-o-acyltransferase-goat-in-goldfish-carassius-auratus
#6
Ayelén Melisa Blanco, Miguel Gómez-Boronat, Ángel Luis Alonso-Gómez, Roman Yufa, Suraj Unniappan, María Jesús Delgado, Ana Isabel Valenciano
Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin's physiological effects and is catalyzed by the polytopic enzyme ghrelin O-acyltransferase (GOAT). The aim of this study was to characterize GOAT in a teleost model, goldfish (Carassius auratus). First, the full-length cDNA sequence was obtained by RT-PCR and rapid amplification of cDNA ends methods. Two highly homologous cDNAs of 1491 and 1413 bp, respectively, named goat-V1 and goat-V2 were identified...
2017: PloS One
https://www.readbyqxmd.com/read/28139040/multiple-night-time-light-emitting-diode-lighting-strategies-impact-grassland-invertebrate-assemblages
#7
Thomas W Davies, Jonathan Bennie, Dave Cruse, Dan Blumgart, Richard Inger, Kevin J Gaston
White light-emitting diodes (LEDs) are rapidly replacing conventional outdoor lighting technologies around the world. Despite rising concerns over their impact on the environment and human health, the flexibility of LEDs has been advocated as a means of mitigating the ecological impacts of globally widespread outdoor night-time lighting through spectral manipulation, dimming and switching lights off during periods of low demand. We conducted a three-year field experiment in which each of these lighting strategies was simulated in a previously artificial light naïve grassland ecosystem...
January 31, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28103829/a-comparison-of-the-effects-of-oral-vs-intravenous-hydration-on-subclinical-acute-kidney-injury-in-living-kidney-donors-a-protocol-of-a-randomised-controlled-trial
#8
Shona Mackinnon, Emma Aitken, Ryan Ghita, Marc Clancy
BACKGROUND: Optimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure. Laparoscopic donor nephrectomy is now the most common method for live donor transplantation, reducing both donor post-operative pain and recovery time. However this procedure exposes kidneys to additional haemodynamic stresses. It has been suggested that donor hydration-particularly the use of preoperative intravenous fluids-may counteract these stresses, reducing subclinical acute kidney injury and ultimately improving long-term renal function...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28059971/geographical-information-system-evaluation-and-trends-of-nonaccidental-trauma-at-a-level-i-trauma-center-pilot-study
#9
Michael Robert Smith, Robert Lee Davis, Patricia Anne Phillips, Tatyana Shvilkina, Kamalijit Kaur, Heather Katrina Tabolt, Matthew Krause, Vincent Galdi
PREMISE: Although trauma may be considered a random act, geographical patterns of trauma potentially emerge. Our institution is unique in that it rests at an intersection of two of the highest areas of poverty and assault in New York City and has adequate data to analyze these patterns. METHODS: We review the incident reports logged by emergency medical services (EMS) technicians arriving with intentionally injured trauma patients from January 1 to December 31, 2013 at a single institution...
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28007845/cabergoline-for-cushing-s-disease-a-large-retrospective-multicenter-study
#10
MULTICENTER STUDY
A Ferriere, C Cortet, P Chanson, B Delemer, P Caron, O Chabre, Y Reznik, J Bertherat, V Rohmer, C Briet, I Raingeard, F Castinetti, A Beckers, L Vroonen, D Maiter, F L Cephise-Velayoudom, M L Nunes, M Haissaguerre, A Tabarin
OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded...
March 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27995731/treatment-of-prednisolone-induced-hyperglycaemia-in-hospitalized-patients-insights-from-a-randomized-controlled-study
#11
Anjana Radhakutty, Jessica L Stranks, Brenda L Mangelsdorf, Sophie M Drake, Gregory W Roberts, Anthony T Zimmermann, Stephen N Stranks, Campbell H Thompson, Morton G Burt
AIM: Prednisolone causes hyperglycaemia predominantly between midday and midnight. Consequently, glargine-based basal-bolus insulin regimens may under treat daytime hyperglycaemia and cause nocturnal hypoglycaemia. We investigated whether an isophane-based insulin regimen is safer and more effective than a glargine-based regimen in hospitalized patients. MATERIALS AND METHODS: Fifty inpatients prescribed ≥20 mg/day prednisolone acutely with (1) finger prick blood glucose level (BGL) ≥15 mmol/L or (2) BGLs ≥10 mmol/L within the previous 24 hours were randomized to either insulin isophane or glargine before breakfast and insulin aspart before meals...
December 20, 2016: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/27986184/the-canadian-gynaecologic-oncology-perioperative-management-survey-baseline-practice-prior-to-implementation-of-enhanced-recovery-after-surgery-eras-society-guidelines
#12
Alon D Altman, Gregg S Nelson
OBJECTIVE: To survey the current practice of Society of Gynecologic Oncology of Canada (GOC) members about preoperative, intraoperative, and postoperative phases of care. The survey was carried out prior to publication of the Enhanced Recovery After Surgery (ERAS) Society gynaecologic/oncology guidelines. METHODS: A survey was developed by the GOC and distributed to all surgical members between September and December 2015. RESULTS: The survey was completed by 77 of 92 practising gynaecologic oncologists (84%), representing 19 centres in 16 cities across Canada...
December 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27853240/modulation-of-light-driven-arousal-by-lim-homeodomain-transcription-factor-apterous-in-large-pdf-positive-lateral-neurons-of-the-drosophila-brain
#13
Naoto Shimada, Show Inami, Shoma Sato, Toshihiro Kitamoto, Takaomi Sakai
Apterous (Ap), the best studied LIM-homeodomain transcription factor in Drosophila, cooperates with the cofactor Chip (Chi) to regulate transcription of specific target genes. Although Ap regulates various developmental processes, its function in the adult brain remains unclear. Here, we report that Ap and Chi in the neurons expressing PDF, a neuropeptide, play important roles in proper sleep/wake regulation in adult flies. PDF-expressing neurons consist of two neuronal clusters: small ventral-lateral neurons (s-LNvs) acting as the circadian pacemaker and large ventral-lateral neurons (l-LNvs) regulating light-driven arousal...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27837400/are-readmissions-after-tha-preventable
#14
Douglas S Weinberg, Matthew J Kraay, Steven J Fitzgerald, Vasu Sidagam, Glenn D Wera
BACKGROUND: Readmissions after total joint arthroplasty have become a key quality measure in elective surgery in the United States. The Affordable Care Act includes the Hospital Readmission Reduction Program, which calls for reduced payments to hospitals with excessive readmissions. This policy uses a method to determine excess readmission ratios and calculate readmission payment adjustments to hospitals, however, it is unclear whether readmission rates are an effective quality metric...
May 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27800461/epidemiological-patterns-of-road-traffic-crashes-during-the-last-two-decades-in-iran-a-review-of-the-literature-from-1996-to-2014
#15
REVIEW
Homayoun Sadeghi-Bazargani, Erfan Ayubi, Saber Azami-Aghdash, Leila Abedi, Alireza Zemestani, Louiz Amanati, Mahmood Moosazadeh, Naeema Syedi, Saeid Safiri
CONTEXT: Despite considerable attention given to health statistics of road traffic crashes (RTCs), the epidemiological aspects of injuries resulting from RTCs are not fully understood in Iran and other developing countries. The aim of this review was to study the epidemiological pattern and issues arising due to RTCs in Iran. EVIDENCE ACQUISITION: The scope of this study involves data from a broad range of published literature on RTCs in Iran. Data collection for this study was conducted by searching for keywords such as traffic accidents, traffic crashes, motorcycle accidents, motorcycle crashes, motorcycle injury, motor vehicle injury, motor vehicle crashes and motor vehicle accidents, Iran and Iranian in various databases such as Embase, PubMed, Google Scholar, Scopus, Magiran, Iranian scientific information database (SID) and IranMedex...
September 2016: Archives of Trauma Research
https://www.readbyqxmd.com/read/27797672/low-dheas-a-sensitive-and-specific-test-for-the-detection-of-subclinical-hypercortisolism-in-adrenal-incidentalomas
#16
M Conall Dennedy, Anand K Annamalai, Olivia Prankerd-Smith, Natalie Freeman, Kuhan Vengopal, Johann Graggaber, Olympia Koulouri, Andrew S Powlson, Ashley Shaw, David J Halsall, Mark Gurnell
Context: Subclinical hypercortisolism (SH) occurs in 5% to 30% of adrenal incidentalomas (AIs). Common screening tests for adrenocorticotropin-independent hypercortisolism have substantial false-positive rates, mandating further time and resource-intensive investigations. Objective: To determine whether low basal dehydroepiandrosterone sulfate (DHEAS) is a sensitive and specific screening test for SH in AI. Setting and Patients: In total, 185 patients with AI were screened for adrenal medullary (plasma metanephrines) and cortical [1 mg overnight dexamethasone suppression test (ONDST), 24-hour urinary free cortisol (UFC), serum DHEAS, plasma renin, and aldosterone] hyperfunction...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27677869/duration-of-nil-per-os-is-causal-in-hospital-length-of-stay-following-laparoscopic-bariatric-surgery
#17
Vaughn E Nossaman, William S Richardson, James B Wooldridge, Bobby D Nossaman
INTRODUCTION: A recent bariatric surgical study demonstrated an inverse relationship of intraoperative hydration with the incidence of extended hospital length of stay (ehLOS: >1 postoperative hospital day). In that study, a post hoc analysis of the preoperative duration of Nil Per Os (NPO) past midnight revealed a significant dose-response association on the incidence of ehLOS, with the lowest incidence (10-12 %) predicted within the 2-5-h NPO interval. As NPO is associated with a state of compensatory dehydration, the objectives of this study were to prospectively examine the role of decreasing preoperative NPO intervals on the incidence of ehLOS in a similar bariatric surgical population and to establish causality of this association...
April 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27390704/a-survey-of-clinical-practice-patterns-in-diagnosis-and-management-of-cushing-s-disease-in-iran
#18
Mojtaba Malek, Fatemeh Esfehanian, Atieh Amouzegar, Farzaneh Sarvghadi, Zohreh Moossavi, Mohammad R Mohajeri-Tehrani, Mohammad E Khamseh, Alireza Amirbaigloo, Ameneh Ebrahim Valojerdi
BACKGROUND: Cushing's disease is the most prevalent cause of endogenous adrenocorticotrophic hormone hypersecretion. The aim of this study was to document the current clinical practice pattern in the management of Cushing's disease by Iranian Endocrinologists to determine their opinions and compare them with the current clinical practice guidelines. METHODS: An eight-item questionnaire dealing with diagnosis, treatment and follow up of patients with Cushing's disease was developed, piloted, and sent to the members of Iranian Endocrinology Society...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27338087/online-responses-to-the-ending-of-the-one-child-policy-in-china-implications-for-preconception-care
#19
Fuqin Liu, Jiaming Bao, Doris Boutain, Marcia Straughn, Olusola Adeniran, Heather DeGrande, Stevan Harrell
AIM: A critical analysis of online public postings in response to the news about the ending of China's one-child policy was conducted. The specific study aims were to 1) identify the dominant public discourse in response to the news about the ending of the one-child policy and the beginning of the new two-child policy, and 2) explore implications for preconception care from the public discourse. MATERIAL AND METHODS: Data sources were 10 top-ranked, online news media sites in China, including one Hong Kong-based media site...
June 24, 2016: Upsala Journal of Medical Sciences
https://www.readbyqxmd.com/read/27323512/cms-backs-off-cuts-due-to-two-midnight-rule
#20
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Hospital Case Management: the Monthly Update on Hospital-based Care Planning and Critical Paths
keyword
keyword
73696
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"