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https://www.readbyqxmd.com/read/28905825/intraocular-pressure-and-its-correlation-with-midnight-plasma-cortisol-level-in-cushing-s-disease-and-other-endogenous-cushing-s-syndrome
#1
Priyadarshini Mishra, Alok Pratap Singh, Vikas Kanaujia, Rachna Agarwal, Prabhaker Mishra, Ashwani Guleria, Alka Tripathi
PURPOSE: The purpose of this study is to measure intraocular pressure (IOP) and evaluate the correlation between IOP and midnight plasma cortisol (MPC) level in patients with Cushing's disease (CD) and other endogenous Cushing's syndrome (ECS). METHODS: This is a cross-sectional study from a single center including newly diagnosed patients with CD or ECS. All patients underwent detailed ophthalmological evaluation. IOP was measured by Goldmann applanation tonometry in the morning and evening on two consecutive days...
September 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28887137/effects-of-a-high-level-of-illumination-before-sleep-at-night-on-chorioretinal-thickness-and-ocular-biometry
#2
Jaemoon Ahn, Soh-Eun Ahn, Kyung-Sook Yang, Seong-Woo Kim, Jaeryung Oh
The choroid is affected by many factors. One of the factors, change in illumination has been suggested to influence choroidal thickness. However, the effects of bright light before sleep at night on the human eye are not well established. The purpose of this study was to investigate the effects of a high level of illumination in the evening on ocular measurements. Twenty-seven men with myopia spent seven consecutive nights in the sleep laboratory. During the first two nights, subjects were exposed to light at 150 lux between 20:00 and midnight...
September 5, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28852405/predictive-determinants-of-scorpion-stings-in-a-tropical-zone-of-south-iran-use-of-mixed-seasonal-autoregressive-moving-average-model
#3
Vahid Ebrahimi, Esmael Hamdami, Mohammad Djaefar Moemenbellah-Fard, Shahrokh Ezzatzadegan Jahromi
BACKGROUND: More than 1.2 million scorpion stings occur annually worldwide, particularly in tropical regions. In the absence of proper medical care, mortality due to venomous scorpion stings is an important public health issue. The aim of the present study is to explore the temporal trend of scorpionism with time series models and determine the effective factors on this event using regression models. METHODS: A retrospective cross sectional study was conducted on 853 scorpion stung patients...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28830569/comparative-study-on-the-nocturnal-activity-of-phlebotomine-sand-flies-in-a-highland-and-lowland-foci-of-visceral-leishmaniasis-in-north-western-ethiopia-with-special-reference-to-phlebotomus-orientalis
#4
Esayas Aklilu, Araya Gebresilassie, Solomon Yared, Mizan Kindu, Habte Tekie, Meshesha Balkew, Alon Warburg, Asrat Hailu, Teshome Gebre-Michael
BACKGROUND: Leishmania donovani, the causative agent of visceral leishmaniasis (VL), is most probably vectored by Phlebotomus orientalis in north-western Ethiopia. The aim of this study was to determine and compare the nocturnal activity patterns of Ph. orientalis in VL endemic foci of Libo-Kemkem (highland) and Metema (lowland) districts of north-western Ethiopia. METHODS: Sampling of sand flies was conducted bimonthly from January-May 2012 in the highland and from March-June 2013 in the lowland...
August 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28811576/microclimatic-temperatures-increase-the-potential-for-vector-borne-disease-transmission-in-the-scandinavian-climate
#5
Najmul Haider, Carsten Kirkeby, Birgit Kristensen, Lene Jung Kjær, Jens Havskov Sørensen, Rene Bødker
We quantified the difference between the meteorological temperature recorded by the Danish Meteorological Institute (DMI) weather stations and the actual microclimatic temperatures at two or three different heights at six potential insect habitats. We then compared the impact of the hourly temperature on the extrinsic incubation period (EIP) of six pathogens. Finally, we developed a regression model, enabling us to predict the microclimatic temperatures of different habitats based on five standard meteorological parameters readily available from any meteorological institution...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28807299/seasonality-and-circadian-variation-of-microfilaremia-in-dogs-experimentally-infected-with-dirofilaria-immitis
#6
Léonore Lovis, Mélanie Grandjean, Laurence Overney, Wolfgang Seewald, Heinz Sager
Periodicity, the cyclical rise and fall in microfilaria (mff) numbers in the peripheral blood over time, is observed in many filarial infections. It is correlated with the necessity for these larval stages to be ingested by the blood feeding vector before they can be transmitted to a new vertebrate host. Microfilariae of the dog heartworm Dirofilaria immitis have been described to show periodicity, but the circadian pattern does not seem to be consistent. Most publications describe the lowest mff-concentrations in the peripheral blood in the early morning, while the highest counts occurred either in the afternoon, in the late evening or shortly after midnight...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28775132/shift-work-that-involves-circadian-disruption-and-breast-cancer-a-first-application-of-chronobiological-theory-and-the-consequent-challenges
#7
Lin Fritschi, J Valérie Groß, Ursula Wild, Jane S Heyworth, Deborah C Glass, Thomas C Erren
OBJECTIVES: In 2007, the International Agency for Research on Cancer classified shift work involving circadian disruption (CD) as probably carcinogenic to humans. Circadian disruption could be conceptualised as the overlap of activity, such as work, with an individual's biological night. The latter can be approximated from a worker's chronotype (or morning/evening preference). Few previous studies have taken chronotype into account when assessing CD caused by shift work. Our objective was to test the hypothesis that women working during their biological night would be at increased risk of breast cancer...
August 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28714288/tolterodine-treatment-of-women-with-overactive-bladder-syndrome-comparison-of-night-time-and-daytime-dosing-for-nocturia
#8
Ko-Hsin Tsai, Sheng-Mou Hsiao, Ho-Hsiung Lin
AIM: We aimed to clarify the impact of night-time dosing with tolterodine extended release (ER) on nocturia. METHODS: The bladder diaries, urodynamic studies, and medical records of female patients with overactive bladder syndrome who were diagnosed between January 2005 and December 2015, and treated with tolterodine ER 4 mg once per day (night-time or daytime dosing) for 12 weeks in the urogynecology outpatient clinics of two tertiary referral centers were reviewed retrospectively...
July 16, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28675833/evaluation-of-compliance-with-the-spanish-code-of-self-regulation-of-food-and-drinks-advertising-directed-at-children-under-the-age-of-12-years-in-spain-2012
#9
K León-Flández, A Rico-Gómez, M Á Moya-Geromin, M Romero-Fernández, M J Bosqued-Estefania, J Damián, L López-Jurado, M Á Royo-Bordonada
OBJECTIVE: To evaluate compliance levels with the Spanish Code of self-regulation of food and drinks advertising directed at children under the age of 12 years (Publicidad, Actividad, Obesidad, Salud [PAOS] Code) in 2012; and compare these against the figures for 2008. STUDY DESIGN: Cross-sectional study. METHODS: Television advertisements of food and drinks (AFD) were recorded over 7 days in 2012 (8am-midnight) of five Spanish channels popular to children...
September 2017: Public Health
https://www.readbyqxmd.com/read/28652955/perioperative-fasting-and-the-patient-experience
#10
Telliane Chon, Alfred Ma, Connie Mun-Price
Standard preparation for a surgical procedure requires patients to fast (nulla per os [NPO]) after midnight before their operation. Unfortunately, given the unpredictable nature of operating room scheduling and unavoidable delays, patients may find themselves anxiously waiting and fasting much longer than expected. In recent years, the usefulness of prolonged fasting to prevent pulmonary aspiration has been questioned. According to the American Society of Anesthesiologists (ASA) guidelines, unnecessarily prolonged fasting can be avoided by allowing patients to have clear liquids with the minimal fasting time of only two hours...
May 24, 2017: Curēus
https://www.readbyqxmd.com/read/28505279/somatic-usp8-gene-mutations-are-a-common-cause-of-pediatric-cushing-disease
#11
Fabio R Faucz, Amit Tirosh, Christina Tatsi, Annabel Berthon, Laura C Hernández-Ramírez, Nikolaos Settas, Anna Angelousi, Ricardo Correa, Georgios Z Papadakis, Prashant Chittiboina, Martha Quezado, Nathan Pankratz, John Lane, Aggeliki Dimopoulos, James L Mills, Maya Lodish, Constantine A Stratakis
Context: Somatic mutations in the ubiquitin-specific protease 8 (USP8) gene have been recently identified as the most common genetic alteration in patients with Cushing disease (CD). However, the frequency of these mutations in the pediatric population has not been extensively assessed. Objective: We investigated the status of the USP8 gene at the somatic level in a cohort of pediatric patients with corticotroph adenomas. Design and Methods: The USP8 gene was fully sequenced in both germline and tumor DNA samples from 42 pediatric patients with CD...
August 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28321939/examining-the-sociocultural-sensitivity-of-subjective-drunkenness-comparing-arab-and-jewish-israeli-pub-patrons
#12
Sharon R Sznitman, Shiran Bord, Wafa Elias, Anat Gesser-Edelsburg, Yoram Shiftan, Orna Baron-Epel
INTRODUCTION AND AIMS: Subjective drunkenness measures may be useful screening tools for alcohol-related problems. However, if self-reported drunkenness is influenced by social and cultural understandings, the measure may not predict drinking patterns equally across different sociocultural groups. The current study aims to determine whether the two main sociocultural groups in Israel (Arabs and Jews) are equally likely to report drunkenness at comparable levels of breath alcohol content (BrAC)...
March 20, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28315773/the-time-enzyme-in-melatonin-biosynthesis-in-fish-day-night-expressions-of-three-aralkylamine-n-acetyltransferase-genes-in-three-spined-stickleback
#13
REVIEW
Ewa Kulczykowska, Agnieszka Kleszczyńska, Magdalena Gozdowska, Ewa Sokołowska
In vertebrates, aralkylamine N-acetyltransferase (AANAT; EC 2.3.1.87) is a time-keeping enzyme in melatonin (Mel) biosynthesis. Uniquely in fish, there are several AANAT isozymes belonging to two AANAT subfamilies, AANAT1 and AANAT2, which are encoded by distinct genes. The different substrate preferences, kinetics and spatial expression patterns of isozymes indicate that they may have different functions. In the three-spined stickleback (Gasterosteus aculeatus), there are three genes encoding three AANAT isozymes...
June 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28270041/bleeding-gastric-and-duodenal-ulcers-case-control-study-comparing-angioembolization-and-surgery
#14
COMPARATIVE STUDY
Taina Nykänen, Erno Peltola, Leena Kylänpää, Marianne Udd
OBJECTIVES: To compare the safety, efficacy and feasibility of transcatheter arterial embolization (TAE) and surgery in the treatment of bleeding gastric and duodenal ulcers (BGDUs). MATERIALS AND METHODS: The study group comprised patients receiving TAE or surgery for BGDUs after failed endoscopic hemostasis in Helsinki University Hospital (HUH) during 2000-2015. Hospital medical records provided study data. 30-d mortality and rebleeding rates were the primary outcomes...
May 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28220407/favourable-outcome-in-two-pregnancies-in-a-patient-with-3-hydroxy-3-methylglutaryl-coa-lyase-deficiency
#15
David Santosa, Markus G Donner, Stephan Vom Dahl, Markus Fleisch, Thomas Hoehn, Ertan Mayatepek, Katrin Heldt, Tim Niehues, Dieter Häussinger
In patients with 3-hydroxy-3-methylglutaryl(HMG)-CoA lyase deficiency (OMIM 246450), five pregnancies have been described worldwide, which were either terminated or resulted in severe metabolic sequelae during pregnancy or delivery. Here, we report on a patient with HMG-CoA lyase deficiency, who underwent two uncomplicated pregnancies. The 19-year-old patient was admitted because of recurrent vomiting and nausea. Diagnostics revealed pregnancy at week 8 of gestation. Metabolic analyses revealed normal lactate and blood glucose levels and normal acid-base status...
February 21, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28178327/characterization-of-ghrelin-o-acyltransferase-goat-in-goldfish-carassius-auratus
#16
Ayelén Melisa Blanco, Miguel Gómez-Boronat, Ángel Luis Alonso-Gómez, Roman Yufa, Suraj Unniappan, María Jesús Delgado, Ana Isabel Valenciano
Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin's physiological effects and is catalyzed by the polytopic enzyme ghrelin O-acyltransferase (GOAT). The aim of this study was to characterize GOAT in a teleost model, goldfish (Carassius auratus). First, the full-length cDNA sequence was obtained by RT-PCR and rapid amplification of cDNA ends methods. Two highly homologous cDNAs of 1491 and 1413 bp, respectively, named goat-V1 and goat-V2 were identified...
2017: PloS One
https://www.readbyqxmd.com/read/28139040/multiple-night-time-light-emitting-diode-lighting-strategies-impact-grassland-invertebrate-assemblages
#17
Thomas W Davies, Jonathan Bennie, Dave Cruse, Dan Blumgart, Richard Inger, Kevin J Gaston
White light-emitting diodes (LEDs) are rapidly replacing conventional outdoor lighting technologies around the world. Despite rising concerns over their impact on the environment and human health, the flexibility of LEDs has been advocated as a means of mitigating the ecological impacts of globally widespread outdoor night-time lighting through spectral manipulation, dimming and switching lights off during periods of low demand. We conducted a three-year field experiment in which each of these lighting strategies was simulated in a previously artificial light naïve grassland ecosystem...
July 2017: Global Change Biology
https://www.readbyqxmd.com/read/28103829/a-comparison-of-the-effects-of-oral-vs-intravenous-hydration-on-subclinical-acute-kidney-injury-in-living-kidney-donors-a-protocol-of-a-randomised-controlled-trial
#18
Shona Mackinnon, Emma Aitken, Ryan Ghita, Marc Clancy
BACKGROUND: Optimal treatment for established renal failure is living donor kidney transplantation. However this pathway exposes healthy individuals to significant reduction in nephron mass via major surgical procedure. Laparoscopic donor nephrectomy is now the most common method for live donor transplantation, reducing both donor post-operative pain and recovery time. However this procedure exposes kidneys to additional haemodynamic stresses. It has been suggested that donor hydration-particularly the use of preoperative intravenous fluids-may counteract these stresses, reducing subclinical acute kidney injury and ultimately improving long-term renal function...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28059971/geographical-information-system-evaluation-and-trends-of-nonaccidental-trauma-at-a-level-i-trauma-center-pilot-study
#19
Michael Robert Smith, Robert Lee Davis, Patricia Anne Phillips, Tatyana Shvilkina, Kamalijit Kaur, Heather Katrina Tabolt, Matthew Krause, Vincent Galdi
PREMISE: Although trauma may be considered a random act, geographical patterns of trauma potentially emerge. Our institution is unique in that it rests at an intersection of two of the highest areas of poverty and assault in New York City and has adequate data to analyze these patterns. METHODS: We review the incident reports logged by emergency medical services (EMS) technicians arriving with intentionally injured trauma patients from January 1 to December 31, 2013 at a single institution...
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28007845/cabergoline-for-cushing-s-disease-a-large-retrospective-multicenter-study
#20
MULTICENTER STUDY
A Ferriere, C Cortet, P Chanson, B Delemer, P Caron, O Chabre, Y Reznik, J Bertherat, V Rohmer, C Briet, I Raingeard, F Castinetti, A Beckers, L Vroonen, D Maiter, F L Cephise-Velayoudom, M L Nunes, M Haissaguerre, A Tabarin
OBJECTIVE: The efficacy of cabergoline in Cushing's disease (CD) is controversial. The aim of this study was to assess the efficacy and tolerability of cabergoline in a large contemporary cohort of patients with CD. DESIGN: We conducted a retrospective multicenter study from thirteen French and Belgian university hospitals. METHODS: Sixty-two patients with CD received cabergoline monotherapy or add-on therapy. Symptom score, biological markers of hypercortisolism and adverse effects were recorded...
March 2017: European Journal of Endocrinology
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