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Premedication

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https://www.readbyqxmd.com/read/28213943/a-phase-2-safety-study-of-accelerated-elotuzumab-infusion-over-less-than-1-hour-in-combination-with-lenalidomide-and-dexamethasone-in-patients-with-multiple-myeloma
#1
James Berenson, Robert Manges, Suprith Badarinath, Alan Cartmell, Kristi McIntyre, Roger Lyons, Wael Harb, Hesham Mohamed, Ali Nourbakhsh, Robert Rifkin
Elotuzumab, an immunostimulatory SLAMF7-targeting monoclonal antibody, induces myeloma cell death with minimal effects on normal tissue. In a previous phase 3 study in patients with relapsed/refractory multiple myeloma (RRMM), elotuzumab (10 mg/kg, ∼3-hour infusion), combined with lenalidomide and dexamethasone, demonstrated durable efficacy and acceptable safety; 10% (33/321) of patients had infusion reactions (IRs; Grade 1/2: 29; Grade 3: 4). This phase 2 study (NCT02159365) investigated an accelerated infusion schedule in 70 patients with newly diagnosed multiple myeloma or RRMM...
February 18, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28211099/sedation-with-orally-administered-midazolam-in-elderly-dental-patients-with-major-neurocognitive-disorder
#2
Lena Rignell, Mona Mikati, Madeleine Wertsén, Catharina Hägglin
OBJECTIVE: The aim of this study was to evaluate acceptance of treatment after oral sedation with midazolam in dental patients with major neurocognitive disorder. BACKGROUND: Midazolam is commonly used as premedication in paediatric dentistry, oral surgery and people suffering from dental fear. Little is known about its use in other patient groups. METHODS: Dental and sedation records of 61 patients (64% women) sedated with midazolam were examined retrospectively...
February 17, 2017: Gerodontology
https://www.readbyqxmd.com/read/28207530/can-quality-of-recovery-be-enhanced-by-premedication-with-midazolam-a-prospective-randomized-double-blind-study-in-females-undergoing-breast-surgery
#3
Myoung Hwa Kim, Min Soo Kim, Jae Hoon Lee, Jae Hi Seo, Jeong-Rim Lee
BACKGROUND: Preoperative anxiety is known to be related with the postoperative outcomes, although it remains unclear whether pharmacologic anxiolysis preoperatively leads to better postanesthesia recovery. Hence, the purpose of this study was to assess whether midazolam premedication would result in improved Quality of Recovery-40 survey scores, as a postoperative recovery parameter, in female patients undergoing mastectomy. METHODS: This randomized double-blind study was performed at Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28192872/premedical-anatomy-experience-and-student-performance-in-medical-gross-anatomy
#4
Peter Kondrashov, Dalton J McDaniel, Rebecca M Jordan
INTRODUCTION: Gross anatomy is considered one of the most important basic science courses in medical education, yet few medical schools require its completion prior to matriculation. The effect of taking anatomy courses before entering medical school on performance in medical gross anatomy has been previously studied with inconsistent results. MATERIALS AND METHODS: The effect of premedical anatomy coursework on performance in medical gross anatomy, overall medical school grade point average (GPA), and Comprehensive Osteopathic Medical Licensing Examination Level 1 (COMLEX 1) score was evaluated in 456 first-year osteopathic medical students along with a survey on its perceived benefits on success in medical gross anatomy course...
February 13, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28190788/a-comparison-of-cardiopulmonary-effects-and-anaesthetic-requirements-of-two-dexmedetomidine-continuous-rate-infusions-in-alfaxalone-anaesthetized-greyhounds
#5
Setefilla Quirós-Carmona, Rocío Navarrete, Juan M Domínguez, María Del Mar Granados, Rafael J Gómez-Villamandos, Pilar Muñoz-Rascón, Daniel Aguilar, Francisco J Funes, Juan Morgaz
OBJECTIVE: To determine the effects of two dexmedetomidine continuous rate infusions on the minimum infusion rate of alfaxalone for total intravenous anaesthesia (TIVA), and subsequent haemodynamic and recovery effects in Greyhounds undergoing laparoscopic ovariohysterectomy. STUDY DESIGN: Prospective, randomized and blinded clinical study. ANIMALS: Twenty-four female Greyhounds. METHODS: Dogs were premedicated with dexmedetomidine 3 μg kg(-1) and methadone 0...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28186425/influence-of-two-administration-rates-of-propofol-at-induction-of-anaesthesia-on-its-relative-potency-in-cats-a-pilot-study
#6
Sébastien H Bauquier, Wendy Bayldon, Leon N Warne, Jennifer E Carter, Thierry Beths
Objectives This was a randomised, blinded trial to investigate the influence of administration rate on the dose of propofol required for the orotracheal intubation of cats. Methods Twenty-four female domestic cats undergoing ovariohysterectomy were premedicated with oral tramadol (6 mg/kg) or intramuscular tramadol (4 mg/kg), and intramuscular dexmedetomidine (0.007 mg/kg). Oral or intramuscular (IM) tramadol was administered 60 or 30 mins prior to induction of anaesthesia, respectively. Dexmedetomidine was administered 30 mins prior to anaesthetic induction...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28183568/the-effect-of-play-distraction-on-anxiety-before-premedication-administration-a-randomized-trial
#7
Gözde Bumin Aydın, Serhat Yüksel, Jülide Ergil, Reyhan Polat, Fatma Kavak Akelma, Musa Ekici, Murat Sayın, Öner Odabaş
STUDY OBJECTIVE: The majority of children scheduled to undergo surgery experience substantial anxiety in the preoperative holding area before induction of anesthesia. Pharmacological interventions aimed at reducing perioperative anxiety are paradoxically a source of stress for children themselves. Midazolam is frequently used as premedication, and the formula of this drug in Turkey is bitter. We aimed to assess the role of distraction in the form of playing with play dough (Play-Doh) on reducing premedication anxiety in children...
February 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28181385/hemodynamic-profile-and-behavioral-characteristics-during-induction-of-anesthesia-in-pediatric-patients-with-attention-deficit-hyperactivity-disorder
#8
Richard S Cartabuke, Joseph D Tobias, Julie Rice, Dmitry Tumin
AIM: There is no consensus regarding the administration of stimulant drugs preoperatively, particularly in pediatric patients diagnosed with ADHD. The primary objective of the current study was to assess differences in blood pressure and heart rate before and after induction of anesthesia between patients on chronic amphetamine or methylphenidate therapy who receive their normal dose preoperatively compared to patients in whom the prescribed medication was withheld. Secondary objectives were to assess the anxiety level during the induction of anesthesia and the effect of premedication with midazolam...
February 8, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28178909/doctoring-undercover-updating-the-educational-tradition-of-shadowing
#9
Claire D Clark
BACKGROUND: Premedical students are educated in basic biological and health sciences. As a complement to traditional premedical coursework, medical school applicants are encouraged to shadow practitioners, with the hope that observation will introduce students to the culture and practice of healthcare. Yet the shadowing experience varies widely across practitioners and institutions; resources that guide students' critical reflection and structure the experience are scarce. DEVELOPMENT: A pilot experiential learning course, Doctoring Undercover: Shadowing and the Culture of Medicine, was developed to fill this gap...
2017: Medical Education Online
https://www.readbyqxmd.com/read/28176903/analysis-of-perioperative-pain-management-in-vascular-surgery-indicates-that-practice-does-not-adhere-with-guidelines-a-retrospective-cross-sectional-study
#10
Krste Boric, Matija Boric, Teo Boric, Livia Puljak
BACKGROUND: Inadequate treatment of pain related to surgery may be associated with complications and prolonged recovery time and increased morbidity and mortality rates. We investigated perioperative pain management in vascular surgery and compared it with the relevant guidelines for the treatment of perioperative pain. METHODS: We conducted a retrospective study on 501 patients who underwent vascular surgery at the University Hospital Split, Croatia. We collected the following data from patients' charts: age, gender, premedication, preoperative patient's physical status, type of surgery, duration of surgery and anesthesia, type of anesthesia, postoperative analgesia, and need for intensive care...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28174940/dop032-hydrocortisone-premedication-withdrawal-in-patients-on-stable-infliximab-maintenance-clinical-and-pharmacokinetic-outcomes
#11
M-L Tran-Minh, M Maillet, C Auzolle, M Simon, A L Cathala, T Aparicio, C Baudry, J Bonnet, N Lourenco, P Houze, J-M Gornet, M Allez
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28165304/effects-of-acepromazine-and-trazodone-on-anesthetic-induction-dose-of-propofol-and-cardiovascular-variables-in-dogs-undergoing-general-anesthesia-for-orthopedic-surgery
#12
Lindsey A Murphy, Michele Barletta, Lynelle F Graham, Lorna J Reichl, Margaret M Duxbury, Jane E Quandt
OBJECTIVE To compare the doses of propofol required to induce general anesthesia in dogs premedicated with acepromazine maleate or trazodone hydrochloride and compare the effects of these premedicants on cardiovascular variables in dogs anesthetized for orthopedic surgery. DESIGN Prospective, randomized study. ANIMALS 30 systemically healthy client-owned dogs. PROCEDURES 15 dogs received acepromazine (0.01 to 0.03 mg/kg [0.005 to 0.014 mg/lb], IM) 30 minutes before anesthetic induction and 15 received trazodone (5 mg/kg [2...
February 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28145266/the-pipeline-of-physiology-courses-in-community-colleges-to-university-medical-school-and-beyond
#13
REVIEW
Jenny McFarland, Pamela Pape-Lindstrom
Community colleges are significant in the landscape of undergraduate STEM (science technology, engineering, and mathematics) education (9), including biology, premedical, and other preprofessional education. Thirty percent of first-year medical school students in 2012 attended a community college. Students attend at different times in high school, their first 2 yr of college, and postbaccalaureate. The community college pathway is particularly important for traditionally underrepresented groups. Premedical students who first attend community college are more likely to practice in underserved communities (2)...
December 2016: Advances in Physiology Education
https://www.readbyqxmd.com/read/28130755/prevention-and-therapy-of-pediatric-emergence-delirium-a-national-survey
#14
Christopher Huett, Torsten Baehner, Felix Erdfelder, Claudia Hoehne, Christian Bode, Andreas Hoeft, Richard K Ellerkmann
INTRODUCTION: Although pediatric emergence delirium (ED) is common, preventive and therapeutic pharmacological treatment is the matter of an international controversial discussion and evidence on different options is partially vague. OBJECTIVE: We therefore examined clinical routine in prevention strategies and postoperative therapy of ED with respect to clinical experience in pediatric anesthesia. METHODS: A web-based survey was developed investigating routine management (prevention and treatment) of ED, facility structure, and patient population...
January 28, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28126530/use-of-clinical-decision-support-to-increase-premedication-regimen-homogeneity
#15
John C Benson, Alexander M McKinney, Paul Hines, Zeke McKinney
PURPOSE: Patients with prior allergic reactions to iodinated contrast require premedication. This study aimed to increase the homogeneity of premedication orders in such patients. METHODS: A point-of-care (POC) clinical decision support (CDS) alert accompanied by an order set was implemented in the electronic health record (EHR) to notify providers of a prior allergic reaction upon ordering an examination involving iodinated contrast. Premedication regimens were retrospectively compared 11 months pre- and 11 months post-alert implementation, with the different regimens being classified as follows: (1) "preferred" (per ACR recommendations), (2) "nonpreferred" (corticosteroid administered <24 hours before examination, but not per ACR recommendations), or (3) "no premedication...
January 23, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28126223/the-evidence-for-and-against-corticosteroid-prophylaxis-in-at-risk-patients
#16
REVIEW
Matthew S Davenport, Richard H Cohan
Corticosteroid prophylaxis is commonly used for the prevention of allergiclike reactions to iodinated and gadolinium-based contrast material in patients at highest risk of an allergiclike reaction. However, it has only a weak mitigating effect on allergiclike reactions, probably does not affect the severity of subsequent reactions, and does not prevent all reactions. Breakthrough reactions occur, are usually the same severity as the index reaction, and can occasionally be life threatening. Premedication of inpatients is likely associated with substantial cost and harm because of hospital length-of-stay prolongation; these indirect effects may exceed the benefits of premedication in this population...
March 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/28111373/interaction-between-maropitant-and-carprofen-on-sparing-of-the-minimum-alveolar-concentration-for-blunting-adrenergic-response-mac-bar-of-sevoflurane-in-dogs
#17
Sho Fukui, Norihiko Ooyama, Jun Tamura, Mohammed Ahmed Umar, Tomohito Ishizuka, Takaharu Itami, Kenjiro Miyoshi, Tadashi Sano, Kazuto Yamashita
Maropitant, a neurokinin-1 receptor antagonist, may provide analgesic effects by blocking pharmacological action of substance P. Carprofen is a non-steroidal anti-inflammatory drug commonly used for pain control in dogs. The purpose of this study was to evaluate the effect of a combination of maropitant and carprofen on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Six healthy adult beagle dogs were anesthetized with sevoflurane four times with a minimum of 7-day washout period...
January 21, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28108038/the-effect-of-endotracheal-tubes-versus-laryngeal-mask-airways-on-perioperative-respiratory-adverse-events-in-infants-a-randomised-controlled-trial
#18
Thomas F E Drake-Brockman, Anoop Ramgolam, Guicheng Zhang, Graham L Hall, Britta S von Ungern-Sternberg
BACKGROUND: Perioperative respiratory adverse events (PRAE) are the most common critical incidents in paediatric anaesthesia and occur more often in infants. Use of laryngeal mask airways (LMAs) is associated with reduced PRAE compared with endotracheal tubes in older children (>1 year). We aimed to evaluate the effect of these devices on the incidence of PRAE in infants. METHODS: We did a randomised controlled trial at the Princess Margaret Hospital for Children in Perth (WA, Australia) by recruiting infants (aged 0-12 months) undergoing general (with or without regional or local) anaesthesia with anticipated fentanyl dose 1 μg/kg or lower for minor elective surgery...
January 17, 2017: Lancet
https://www.readbyqxmd.com/read/28107080/the-influence-of-a-combined-butorphanol-and-midazolam-premedication-on-anesthesia-in-psittacid-species
#19
Marie Kubiak, Louise Roach, Kevin Eatwell
Premedication is considered routine for domestic animal and human anesthesia but is rarely applied to avian patients, and few controlled studies exist to document effects of premedication in avian species. To determine the effects of a butorphanol and midazolam premedication on general anesthesia and quality of induction and recovery phases in psittacid species, 17 clinically healthy birds undergoing anesthesia were randomly allocated into either a premedicated or control group. Anesthetic parameters were subsequently compared...
December 2016: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/28100529/children-and-parental-anxiolysis-in-paediatric-ambulatory-surgery-a-randomized-controlled-study-comparing-0-3%C3%A2-mg-kg-1-midazolam-to-tablet-computer-based-interactive-distraction
#20
C Marechal, J Berthiller, S Tosetti, B Cogniat, H Desombres, L Bouvet, B Kassai, D Chassard, M de Queiroz Siqueira
BACKGROUND: The operating theatre, anaesthesia induction and separation from parents create fear and anxiety in children. Anxiety leads to adverse behavioral changes appearing and sometimes persisting during the postoperative period. Our aim was to compare the effects of midazolam (0.3 mg kg(-)(1): MDZ) for premedication with age-appropriate tablet game apps (TAB) on children anxiety during and after ambulatory surgery. METHODS: A randomized controlled trial was conducted from May 16th, 2013 to March 25th, 2014 at the Children Hospital of Lyon...
February 2017: British Journal of Anaesthesia
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