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https://www.readbyqxmd.com/read/29146451/effect-of-rate-of-administration-of-propofol-or-alfaxalone-on-induction-dose-requirements-and-occurrence-of-apnea-in-dogs
#1
Sarah E Bigby, Thierry Beths, Sébastien Bauquier, Jennifer E Carter
OBJECTIVE: To evaluate the effect of rate of administration of propofol or alfaxalone on induction dose requirements and incidence of postinduction apnea (PIA) in dogs following premedication with methadone and dexmedetomidine. STUDY DESIGN: Prospective, randomized clinical trial. ANIMALS: Thirty-two healthy American Society of Anesthesiologists class I client-owned dogs (seven females, 25 males), aged between 5 and 54 months, weighing between 2...
May 2, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29140940/rapid-infliximab-infusion-in-children-with-inflammatory-bowel-disease-a-multicenter-north-american-experience
#2
Wael El-Matary, Dana M H Dykes, Laura Bauman, Abdul Elkadri, Matthew W Carroll, Marisa R Izaguirre, Jennifer deBruyn, Charles M Samson, Alisa Muniz Crim, Sabina Ali, Andrew Grossman
BACKGROUND: Infliximab (IFX) infusion may lead to development of anti-IFX antibodies, and subsequent infusion reactions (IRs). The safety of rapid IFX infusion administered over 60 minutes has been under-investigated in children with inflammatory bowel disease. In a multicenter study, the frequency and nature of rapid infusion-associated IRs were examined. METHODS: The medical records of all consecutive children with inflammatory bowel disease receiving rapid IFX infusions between January 2014 and December 2016 were reviewed...
December 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29127153/analysis-of-unsuccessful-intubations-in-neonates-using-videolaryngoscopy-recordings
#3
Joyce E O'Shea, Prakash Loganathan, Marta Thio, C Omar Farouk Kamlin, Peter G Davis
OBJECTIVES: Neonatal intubation is a difficult skill to learn and teach. If an attempt is unsuccessful, the intubator and instructor often cannot explain why. This study aims to review videolaryngoscopy recordings of unsuccessful intubations and explain the reasons why attempts were not successful. STUDY DESIGN: This is a descriptive study examining videolaryngoscopy recordings obtained from a randomised controlled trial that evaluated if neonatal intubation success rates of inexperienced trainees were superior if they used a videolaryngoscope compared with a laryngoscope...
November 10, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29126843/the-role-of-platelet-reactivity-assessment-in-dual-antiplatelet-prophylaxis-after-transcatheter-aortic-valve-implantation
#4
Katarzyna Czerwińska-Jelonkiewicz, Adam Witkowski, Maciej Dąbrowski, Walerian Piotrowski, Tomasz Hryniewiecki, Janina Stępińska
BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended prophylaxis after transcatheter aortic valve implantation (TAVI). The usefulness of platelet reactivity (PLTR) tests in predicting the safety of periprocedural DAPT in the TAVI population is unknown. AIM: To analyze the value of aspirin/clopidogrel PLTR testing in predicting the risk of in-hospital TAVI-related bleeding. METHODS: PLTR, expressed as P2Y12/aspirin reaction units (PRU/ARU), was performed using optical aggregometry with the VerifyNow(®) device, in the 24h before and on the sixth day after TAVI...
November 7, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29099319/effect-of-catheter-gauge-on-the-success-of-intravenous-catheter-placement-by-veterinary-students
#5
Erik H Hofmeister, Jane Quandt
The purposes of this study were to determine if senior veterinary students find it easier to place a smaller-bore catheter, and to relate patient variables with student success in catheter placement. For dogs between 10 kg and 20 kg, the catheter size options were 20 gauge or 22 gauge. For dogs larger than 20 kg, the catheter size options were 18 gauge or 20 gauge. Variables recorded included time for catheter placement, number of catheterization attempts, number of catheters used, number of legs used, difficulty of catheterization, student success, and patient characteristics including signalment, weight, body condition score, premedication drugs given, tentative diagnosis, and procedure...
November 3, 2017: Journal of Veterinary Medical Education
https://www.readbyqxmd.com/read/29099261/effect-of-blood-collection-by-the-push-pull-technique-from-an-indwelling-catheter-versus-direct-venipuncture-on-venous-blood-gas-values-before-and-after-administration-of-alfaxalone-or-propofol-in-dogs
#6
Ciara A Barr, Giacomo Gianotti, Carly E Graffeo, Kenneth J Drobatz, Deborah C Silverstein
OBJECTIVE To compare the effect of blood collection by a push-pull technique from an indwelling IV catheter versus direct venipuncture on venous blood gas values before and after administration of alfaxalone or propofol to dogs. DESIGN Prospective randomized clinical study. ANIMALS 30 healthy client-owned dogs that weighed ≥ 10 kg (22 lb) and were anesthetized for elective surgical procedures. PROCEDURES All dogs were premedicated with methadone (0.5 mg/kg [0.2 mg/lb], IM), and 20 to 30 minutes later, anesthesia was induced with either alfaxalone (1 to 3 mg/kg [0...
November 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29076369/cardiovascular-effects-of-premedication-with-medetomidine-alone-and-in-combination-with-mk-467-or-glycopyrrolate-in-dogs-subsequently-anesthetized-with-isoflurane
#7
Kati M Salla, Cosmin I Tuns, Rachel C Bennett, Marja R Raekallio, Mika Scheinin, Erja Kuusela, Outi M Vainio
OBJECTIVE To compare cardiovascular effects of premedication with medetomidine alone and with each of 3 doses of MK-467 or after glycopyrrolate in dogs subsequently anesthetized with isoflurane. ANIMALS 8 healthy purpose-bred 5-year-old Beagles. PROCEDURES In a randomized crossover study, each dog received 5 premedication protocols (medetomidine [10 μg/kg, IV] alone [MED] and in combination with MK-467 at doses of 50 [MMK50], 100 [MMK100], and 150 [MMK150] μg/kg and 15 minutes after glycopyrrolate [10 μg/kg, SC; MGP]), with at least 14 days between treatments...
November 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29074303/effect-of-dexmedetomidine-on-the-minimum-infusion-rate-of-propofol-preventing-movement-in-dogs
#8
Christopher K Smith, Reza Seddighi, Sherry K Cox, Xiaocun Sun, Heather K Knych, Thomas J Doherty
OBJECTIVE: To determine the effect of dexmedetomidine on induction dose and minimum infusion rate of propofol preventing movement (MIRNM). STUDY DESIGN: Randomized crossover, unmasked, experimental design. ANIMALS: Three male and three female healthy Beagle dogs weighing 10.2 ± 2.8 kg. METHODS: Dogs were studied on three occasions at weekly intervals. Premedications were 0.9% saline (treatment P) or dexmedetomidine (1 μg kg(-1), treatment PLD; 2 μg kg(-1), treatment PHD) intravenously...
August 3, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29071770/the-child-s-behavior-during-inhalational-induction-and-its-impact-on-the-anesthesiologist-s-sevoflurane-exposure
#9
Jennifer Herzog-Niescery, Heike Vogelsang, Martin Bellgardt, Nikolaj Matthias Botteck, Hans-Martin Seipp, Horst Bartz, Thomas Peter Weber, Philipp Gude
BACKGROUND: Sevoflurane is commonly used for inhalational inductions in children, but the personnel's exposure to it is potentially harmful. Guidance to reduce gas pollution refers mainly to technical aspects, but the impact of the child's behavior has not yet been studied. AIMS: The purpose of this study was to determine how child behavior, according to the Frankl Behavioral Scale, affects the amount of waste sevoflurane in anesthesiologists' breathing zones. METHODS: Sixty-eight children aged 36-96 months undergoing elective ENT surgery were recruited for this prospective, observational investigation...
December 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29057764/evaluation-of-total-intravenous-anesthesia-with-propofol-guaifenesin-medetomidine-and-alfaxalone-guaifenesin-medetomidine-in-thoroughbred-horses-undergoing-castration
#10
Motoki Aoki, Ai Wakuno, Asuka Kushiro, Naomi Mae, Masashi Kakizaki, Shun-Ichi Nagata, Minoru Ohta
Anesthetic and cardiorespiratory effects of total intravenous anesthesia (TIVA) technique using propofol-guaifenesin-medetomidine (PGM) and alfaxalone-guaifenesin-medetomidine (AGM) were preliminarily evaluated in Thoroughbred horses undergoing castration. Twelve male Thoroughbred horses were assigned randomly into two groups. After premedication with intravenous (IV) administrations of medetomidine (5.0 μg/kg) and butorphanol (0.02 mg/kg), anesthesia was induced with guaifenesin (10 mg/kg IV), followed by either propofol (2...
October 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29055450/management-of-infusion-related-reactions-associated-with-alemtuzumab-in-patients-with-multiple-sclerosis
#11
Saša Šega-Jazbec, Barbara Barun, Alenka Horvat Ledinek, Višnja Fabekovac, Magdalena Krbot Skorić, Mario Habek
OBJECTIVE: Infusion-associated reactions (IARs) occur in >90% patients with multiple sclerosis (MS) treated with alemtuzumab. We aimed to study the frequency of IARs at 2 sites using 5 days of steroids (1g/day of IV methylprednisolone), but otherwise distinct protocols. METHODS: This was retrospective chart review of 38 consecutive MS patients who were treated with alemtuzumab from June 2015 till February 2017 at Department of Neurology, University Hospital Center Zagreb, Croatia and Department of Neurology, University Medical Center Ljubljana, Slovenia...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29051828/intubation-following-high-dose-rocuronium-in-a-cat-with-protracted-laryngospasm
#12
Graeme M Doodnaught, Daniel Sj Pang
CASE SUMMARY: An 11-year-old spayed female domestic shorthair cat with a history of laryngospasm at induction of general anesthesia presented for dental evaluation and treatment. The cat was premedicated with hydromorphone (0.05 mg/kg) and alfaxalone (0.5 mg/kg) intravenously, pre-oxygenated for 5 mins (3 l/min, face mask) and anesthesia was induced with alfaxalone (to effect) intravenously. Lidocaine (0.1 ml, 2%) was applied topically to the arytenoid cartilages following loss of jaw tone...
July 2017: JFMS open reports
https://www.readbyqxmd.com/read/29045274/recruiting-american-indian-alaska-native-students-to-medical-school-a-multi-institutional-alliance-in-the-u-s-southwest
#13
Marlene P Ballejos, Polly Olsen, Tanisha Price-Johnson, Cindy Garcia, Tassy Parker, Robert E Sapién, Valerie Romero-Leggott
PROBLEM: Despite national efforts to diversify the physician workforce, American Indian/Alaska Native (AI/AN) individuals have the least representation of all major racial and ethnic groups. Limited resources at state medical schools present institution-level recruitment challenges. Unified efforts to engage AI/AN students in premedical education activities are needed. APPROACH: The medical schools at the Universities of Arizona (Phoenix and Tucson), Colorado, New Mexico, and Utah identified a collective need to increase student diversity, particularly with regard to AI/AN students...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29043601/pupillary-reflex-dilation-in-response-to-incremental-nociceptive-stimuli-in-patients-receiving-intravenous-ketamine
#14
Nada Sabourdin, Thomas Giral, Risa Wolk, Nicolas Louvet, Isabelle Constant
Pupillometry is a non-invasive monitoring technique, which allows dynamic pupillary diameter measurement by an infrared camera. Pupillary diameter increases in response to nociceptive stimuli. In patients anesthetized with propofol or volatile agents, the magnitude of this pupillary dilation is related to the intensity of the stimulus. Pupillary response to nociceptive stimuli has never been studied under ketamine anesthesia. Our objective was to describe pupillary reflex dilation after calibrated tetanic stimulations in patients receiving intravenous ketamine...
October 17, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29038874/ultrasound-guided-popliteal-sciatic-block-provides-adequate-analgesia-during-urgent-endovascular-treatment-of-critical-limb-ischemia-with-resting-pain
#15
Derya Tureli, Sinan Deniz, Aytekin Unlukaplan, Levent Oguzkurt
PURPOSE: To demonstrate feasibility and safety of ultrasound-guided popliteal sciatic nerve block for providing analgesia during urgent endovascular treatment of critical limb ischemia with resting pain. MATERIALS AND METHODS: Ultrasound-guided popliteal sciatic blocks were performed by an interventional radiologist in angiography suite immediately prior to commencement of urgent endovascular treatment of 30 critical limb ischemia patients. Subjective pain levels prior to and following sciatic block were assessed using the visual analog scale (VAS)...
October 16, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29037773/use-of-n-acetylcysteine-plus-simethicone-to-improve-the-mucosal-visibility-during-upper-gi-endoscopy-a-double-blind-randomized-controlled-trial
#16
Hugo Monrroy, Jose Ignacio Vargas, Esteban Glasinovic, Roberto Candia, Emilio Azúa, Camila Gálvez, Camila Rojas, Natalia Cabrera, Josefa Vidaurre, Natalia Álvarez, Jessica González, Alberto Espino, Robinson González, Adolfo Parra-Blanco
BACKGROUND AND AIM: Upper GI endoscopy (UGE) is essential for diagnosis of gastrointestinal diseases. Mucus and bubbles may decrease mucosal visibility. The use of mucolytics could improve visualization. Our aim was to determine whether premedication with Simethicone or Simethicone plus N-acetylcysteine is effective improving visibility during UGE. METHODS: This was a randomized, double-blinded, placebo-controlled trial with 2 control groups: no intervention (NI) and water 100 mL (W); and 3 intervention groups: simethicone 200 mg (S); S+NAC 500 mg (S+NAC500); and S+NAC 1000 mg (S+NAC1000)...
October 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29037061/-the-role-of-steroids-in-oncological-practice
#17
Zsófia Küronya, Lajos Géczi, Fruzsina Gyergyay, Krisztina Bíró
Corticosteroids are a class of steroid hormones that are produced and disengage in the adrenal cortex. Traditionally natural and synthetic corticosteroids are used for diagnosing and treating dysfunctions of the adrenal cortex and treating inflammatory and immunological diseases. Their use is also widespread in oncological practice. Corticosteroids are indispensable in palliative care, in certain urgent oncological cases, as premedication of some chemotherapies and last but not least they have a key role in the secondary hormonal manipulations of metastatic castrate-resistant prostate cancer...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29033246/effect-of-choline-chloride-premedication-on-xylazine-induced-hypoxaemia-in-sheep
#18
Preet M Singh, Katherine Reid, Ravindra Gaddam, Madhav Bhatia, Stefan Smith, Antony Jacob, Paul Chambers
OBJECTIVE: To determine the anti-inflammatory efficacy of choline in vivo and in vitro and to investigate the anti-inflammatory mechanisms of choline. STUDY DESIGN: Randomized, controlled studies. ANIMALS: In vivo trials used 16 Romney sheep. In vitro experiments utilized RAW 264.7 mouse macrophage cells. METHODS: Hypoxaemia induced in 16 sheep by intravenous (IV) injection of 50 μg kg(-1) xylazine, an α-2 agonist, was measured in sheep at 0, 1 and 4 minutes using arterial blood gas analysis with and without 50 mg kg(-1) IV choline chloride premedication...
March 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29033245/clinical-comparison-of-alfaxalone-ketamine-and-propofol-following-medetomidine-and-methadone-in-dogs
#19
Kate L White, David Yates
OBJECTIVE: To compare the clinical effects of alfaxalone, ketamine and propofol in dogs following premedication with medetomidine and methadone. STUDY DESIGN: Prospective, 'blinded' and randomized clinical study. ANIMALS: A total of 75 male dogs presented for neutering at a charity clinic. METHODS: Dogs were allocated to be administered alfaxalone, ketamine or propofol following premedication with medetomidine (20 μg kg(-1)) and methadone (0...
March 6, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29032916/combination-of-magnesium-sulphate-and-ropivacaine-epidural-analgesia-for-hip-arthroplasty-in-dogs
#20
Elena Lardone, Bruno Peirone, Chiara Adami
OBJECTIVE: The aim of this study was to determine whether lumbosacral epidural administration of magnesium sulphate added to ropivacaine prolongs and improves perioperative analgesia, without adverse effects on motor block duration or hind limb neurological function, in dogs undergoing hip arthroplasty. STUDY DESIGN: Investigator-blind, controlled, randomized, prospective clinical trial. ANIMALS: A group of 20 client-owned dogs undergoing hip arthroplasty were allocated randomly to either group C (control, 1 mg kg(-1)epidural ropivacaine) or group M (magnesium, epidural injection of 1 mg kg(-1) ropivacaine and 2 mg kg(-1)magnesium sulphate)...
June 16, 2017: Veterinary Anaesthesia and Analgesia
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