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cognitive impairment and CKD

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https://www.readbyqxmd.com/read/28734655/cognitive-function-in-children-with-lupus-nephritis-a-cross-sectional-comparison-with-children-with-other-glomerular-chronic-kidney-diseases
#1
Andrea Knight, Amy J Kogon, Matthew B Matheson, Bradley A Warady, Susan L Furth, Stephen R Hooper
OBJECTIVE: To identify factors contributing to cognitive impairment in children with lupus nephritis. STUDY DESIGN: A cross-sectional analysis of a large multicenter national cohort of children with chronic kidney disease (CKD) using standardized measures to determine baseline neuropsychiatric function and health-related quality of life (HRQoL) in children with lupus nephritis (n = 34), and to compare baseline function with that in children with other forms of glomerular CKD (gCKD; n = 171)...
July 19, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28695442/fistula-first-initiative-historical-impact-on-vascular-access-practice-patterns-and-influence-on-future-vascular-access-care
#2
Timmy Lee
The vascular access is the lifeline for the hemodialysis patient. In the United States, the Fistula First Breakthrough Initiative (FFBI) has been influential in improving use of arteriovenous fistulas (AVF) in prevalent hemodialysis patients. Currently, prevalent AVF rates are near the goal of 66% set forth by the original FFBI. However, central venous catheter (CVC) rates remain very high in the United States in patients initiating hemodialysis, nearly exceeding 80%. A new direction of the of the FFBI has focused on strategies to reduce CVC use, and subsequently the FFBI has now been renamed the "Fistula First-Catheter Last Initiative"...
July 10, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28659394/pulse-wave-velocity-is-associated-with-cognitive-impairment-in-haemodialysis-patients
#3
Eve Miller-Hodges, Neeraj Dhaun
Chronic kidney disease (CKD) is common, its prevalence increasing with age. Cognitive impairment is common in the elderly, in CKD and in those on maintenance haemodialysis. As cognitive impairment is the precursor to dementia, the identification of reversible risk factors for cognitive decline is the key to reducing dementia risk. Arterial stiffness is one such potential risk factor. It is independently associated with cardiovascular outcome in dialysis patients. Importantly, the recent demonstration of an independent association between arterial stiffness and cognitive impairment in these patients suggests that vascular stiffness might be potentially causative in the development of cognitive impairment and also be an opportune target for interventions...
July 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28638609/cognitive-function-and-advanced-kidney-disease-longitudinal-trends-and-impact-on-decision-making
#4
Osasuyi Iyasere, David Okai, Edwina Brown
Background: Cognitive impairment commonly affects renal patients. But little is known about the influence of dialysis modality on cognitive trends or the influence of cognitive impairment on decision-making in renal patients. This study evaluated cognitive trends amongst chronic kidney disease (CKD), haemodialysis (HD) and peritoneal dialysis (PD) patients. The relationship between cognitive impairment and decision-making capacity (DMC) was also assessed. Methods: Patients were recruited from three outpatient clinics...
February 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28621826/cerebral-metabolic-alterations-and-cognitive-dysfunction-in-children-with-chronic-kidney-disease-using-magnetic-resonance-spectroscopy-and-wechsler-intelligence-scale
#5
Doaa Mohammed Youssef, Ahmed Hosny Mohamed, Wafaa Mahmoud Kamel Attia, Faten Fawzy Mohammad, Nelly Rafaat Abd El Fatah, Amal Saeed Elshal
BACKGROUND: Many studies described Impaired intelligence, attention, memory and executive function in patients with chronic kidney disease (CKD) dialyzed and non-dialyzed, but there is still lacking the early and sensitive method of detection of these deficits. The purpose of this study is to investigate relation between the brain metabolic alteration [measured by magnetic resonance spectroscopy (MRS)] and cognitive dysfunction in CKD children (detected by psychometric analysis). SUBJECTS AND METHODS: One hundred and forty patients with CKD were included [ 40 patients with stage 5 CKD on dialysis, 30 patients with stage 4 to 5 CKD without dialysis, and 70 patients with stage 1 to 3 CKD]...
June 16, 2017: Nephrology
https://www.readbyqxmd.com/read/28515344/kidney-brain-axis-inflammatory-cross-talk-from-bench-to-bedside
#6
REVIEW
Aline Silva Miranda, Thiago Macedo Cordeiro, Thomas Mucida Dos Santos Lacerda Soares, Rodrigo Novaes Ferreira, Ana Cristina Simões E Silva
Epidemiologic data suggest that individuals at all stages of chronic kidney disease (CKD) have a higher risk of developing neuropsychiatric disorders, cognitive impairment, and dementia. This risk is generally explained by the high prevalence of both symptomatic and subclinical ischemic cerebrovascular lesions. However, other potential mechanisms, including cytokine/chemokine release, production of reactive oxygen species (ROS), circulating and local formation of trophic factors and of renin-angiotensin system (RAS) molecules, could also be involved, especially in the absence of obvious cerebrovascular disease...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28503567/cognitive-impairment-in-chronic-kidney-disease-vascular-milieu-and-the-potential-therapeutic-role-of-exercise
#7
REVIEW
Ulf G Bronas, Houry Puzantian, Mary Hannan
Chronic kidney disease (CKD) is considered a model of accelerated aging. More specifically, CKD leads to reduced physical functioning and increased frailty, increased vascular dysfunction, vascular calcification and arterial stiffness, high levels of systemic inflammation, and oxidative stress, as well as increased cognitive impairment. Increasing evidence suggests that the cognitive impairment associated with CKD may be related to cerebral small vessel disease and overall impairment in white matter integrity...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28495909/pulse-wave-velocity-is-associated-with-cognitive-impairment-in-hemodialysis-patients
#8
Susanne Angermann, Marcus Baumann, Siegfried Wassertheurer, Christopher Clemens Mayer, Dominik Steubl, Christine Hauser, Yana Suttmann, Anna-Lena Reichelt, Robin Satanovskij, Georg Lorenz, Moritz Lukas, Bernhard Haller, Uwe Heemann, Timo Grimmer, Christoph Schmaderer
BACKGROUND: Cognitive impairment in hemodialysis patients is common and associated with adverse outcomes. So far, the underlying pathogenesis remains unclear. Therefore, we examined the potential relationship between cognitive impairment and three different categories of risk factors with particular focus on arterial stiffness measured by Pulse Wave Velocity (PWV). METHODS: A total of 201 chronic hemodialysis patients underwent cognitive testing under standardized conditions using the Montreal Cognitive Assessment (MoCA)...
May 11, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28477083/peritoneal-dialysis-reduces-amyloid-beta-plasma-levels-in-humans-and-attenuates-alzheimer-associated-phenotypes-in-an-app-ps1-mouse-model
#9
Wang-Sheng Jin, Lin-Lin Shen, Xian-Le Bu, Wei-Wei Zhang, Si-Han Chen, Zhi-Lin Huang, Jia-Xiang Xiong, Chang-Yue Gao, Zhifang Dong, Ya-Ni He, Zhi-An Hu, Hua-Dong Zhou, Weihong Song, Xin-Fu Zhou, Yi-Zheng Wang, Yan-Jiang Wang
Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer's disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous study, we found that peripheral tissues and organs play important roles in clearing brain-derived Aβ, suggesting that the peripheral approach of removing Aβ from the blood may also be effective for AD therapy. Here, we investigated whether peritoneal dialysis, a clinically available therapeutic method for chronic kidney disease (CKD), reduces brain Aβ burden and attenuates AD-type pathologies and cognitive impairments...
May 5, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28439566/inflammatory-markers-and-risk-for-cognitive-decline-in-chronic-kidney-disease-the-cric-study
#10
Manjula Kurella Tamura, Karman Tam, Eric Vittinghoff, Dominic Raj, Stephen M Sozio, Sylvia E Rosas, Gail Makos, Claudia Lora, Jiang He, Alan S Go, Chi-Yuan Hsu, Kristine Yaffe
INTRODUCTION: Chronic kidney disease (CKD) is associated with an increased risk of cognitive decline, but the mechanisms remain poorly defined. We sought to determine the relation between serum inflammatory markers and risk of cognitive decline among adults with CKD. METHODS: We studied 757 adults aged ≥55 years with CKD participating in the Chronic Renal Insufficiency Cohort Cognitive study. We measured interleukin (IL)-1β, IL-1 receptor antagonist, IL-6, tumor necrosis factor (TNF)-α, high-sensitivity C-reactive protein (hs-CRP), and fibrinogen in baseline plasma samples...
March 2017: KI Reports
https://www.readbyqxmd.com/read/28396108/augmented-nurse-care-management-in-ckd-stages-4-to-5-a%C3%A2-randomized-trial
#11
Steven Fishbane, Sofia Agoritsas, Alessandro Bellucci, Candice Halinski, Hitesh H Shah, Vipul Sakhiya, Leah Balsam
BACKGROUND: Outcomes for patients with late-stage chronic kidney disease (CKD) in the United States are suboptimal. There is poor education and preparation for end-stage kidney disease, as well as a high rate of hospitalization in this group of patients. STUDY DESIGN: A randomized, parallel-group, 2-arm, controlled trial. SETTING & PARTICIPANTS: The study was conducted at 3 sites: a clinic of an academic medical center, a public hospital academic clinic, and a community-based private practice...
April 7, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28341210/chronic-kidney-disease-and-subclinical-brain-infarction-increase-the-risk-of-vascular-cognitive-impairment-the-sefuri-study
#12
Hiroshi Yao, Yuko Araki, Yuki Takashima, Akira Uchino, Takefumi Yuzuriha, Manabu Hashimoto
BACKGROUND AND PURPOSE: The purpose of this study was to determine the complex associations among chronic kidney disease (CKD), subclinical brain infarction (SBI), and cognitive impairment. METHODS: We used structural equation modeling (SEM) to examine the complex relationships among CKD, SBI, and cognitive function with Mini-Mental State Examination (MMSE; global function) and modified Stroop test (executive function) in a population-based cohort of 560 non-demented elderly subjects...
February 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28261781/cognitive-impairment-and-hippocampal-atrophy-in-chronic-kidney-disease
#13
C-Y Chang, C-C Lin, C-F Tsai, W-C Yang, S-J Wang, F-H Lin, J-L Fuh
BACKGROUND: Cognition impairment is well known in patients with chronic kidney disease (CKD). The relationship between brain structure and cognitive performance in CKD patients is still under investigation. The study aimed to quantitatively assess the relationship between brain structure and cognitive performance in patients with CKD. METHODS: We recruited 39 patients with CKD and 39 age- and sex-matched control participants from a tertiary medical center. All participants underwent 3-T MRI scan neuropsychological assessments, and renal function tests...
March 5, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28209982/severe-decline-of-estimated-glomerular-filtration-rate-associates-with-progressive-cognitive-deterioration-in-the-elderly-a-community-based-cohort-study
#14
Yi-Chi Chen, Shuo-Chun Weng, Jia-Sin Liu, Han-Lin Chuang, Chih-Cheng Hsu, Der-Cherng Tarng
Cognitive dysfunction is closely related to aging and chronic kidney disease (CKD). However, the association between renal function changes and the risk of developing cognitive impairment has not been elucidated. This longitudinal cohort study was to determine the influence of annual percentage change in estimated glomerular filtration rate (eGFR) on subsequent cognitive deterioration or death of the elderly within the community. A total of 33,654 elders with eGFR measurements were extracted from the Taipei City Elderly Health Examination Database...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163506/related-factors-and-predictors-of-cognitive-dysfunction-in-chronic-kidney-disease-on-maintenance-hemodialysis-in-nigeria
#15
Lukman Femi Owolabi, Aliyu Abdu, Aliyu Ibrahim, Desola Shakirah Owolabi, Aisha Nalado, Adamu Bappa, Aminu Abdullahi Taura
BACKGROUND: Previous studies suggest a high frequency of cognitive impairment (CI) in persons with chronic kidney disease (CKD); however, factors associated with CI and predictors of CI in persons with CKD remain largely unclear. The aim of this study was to determine the factors associated with CI and predictors of CI in CKD patients on maintenance hemodialysis. MATERIALS AND METHODS: The first stage of the study included recruitment of 100 apparently healthy participants aimed at determining the reference values...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28148557/symptom-management-of-the-patient-with-ckd-the-role-of-dialysis
#16
Valerie Jorge Cabrera, Joni Hansson, Alan S Kliger, Fredric O Finkelstein
As kidney disease progresses, patients often experience a variety of symptoms. A challenge for the nephrologist is to help determine if these symptoms are related to advancing CKD or the effect of various comorbidities and/or medications prescribed. The clinician also must decide the timing of dialysis initiation. The initiation of dialysis can have a variable effect on quality of life measures and the alleviation of uremic signs and symptoms, such as anorexia, fatigue, cognitive impairment, depressive symptoms, pruritus, and sleep disturbances...
April 3, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28148556/cognitive-testing-in-patients-with-ckd-the-problem-of-missing-cases
#17
Denise Neumann, Maxi Robinski, Wilfried Mau, Matthias Girndt
BACKGROUND AND OBJECTIVES: Cognitive testing is only valid in individuals with sufficient visual and motor skills and motivation to participate. Patients on dialysis usually suffer from limitations, such as impaired vision, motor difficulties, and depression. Hence, it is doubtful that the true value of cognitive functioning can be measured without bias. Consequently, many patients are excluded from cognitive testing. We focused on reasons for exclusion and analyzed characteristics of nontestable patients...
March 7, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28101100/the-utility-of-the-mini-addenbrooke-s-cognitive-examination-as-a-screen-for-cognitive-impairment-in-elderly-patients-with-chronic-kidney-disease-and-diabetes
#18
Peter Hobson, Kamel H Rohoma, Stephen P Wong, Mick J Kumwenda
BACKGROUND/AIMS: We tested the utility of the Mini-Addenbrooke's Cognitive Examination (M-ACE) in a cohort of older adults with chronic kidney disease (CKD) and diabetes. METHOD: The M-ACE was administered to 112 CKD and diabetes patients attending a nephrology clinic. Cognitive impairment was based upon patient, informant, and case review, neuropsychological assessment, and application of criteria for mild cognitive impairment (MCI) and the Diagnostic and Statistical Manual of Mental Disorders, fifth edition for dementia...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27964726/cognition-in-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#19
REVIEW
Israel Berger, Sunny Wu, Philip Masson, Patrick J Kelly, Fiona A Duthie, William Whiteley, Daniel Parker, David Gillespie, Angela C Webster
BACKGROUND: Cognitive impairment is common in people with chronic kidney disease (CKD) and associated with increased morbidity and mortality. Subtle changes can impact engagement with healthcare, comprehension, decision-making, and medication adherence. We aimed to systematically summarise evidence of cognitive changes in CKD. METHODS: We searched MEDLINE (March 2016) for cross-sectional, cohort or randomised studies that measured cognitive function in people with CKD (PROSPERO, registration number CRD42014015226)...
December 14, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27916702/chronic-kidney-disease-accelerates-cognitive-impairment-in-a-mouse-model-of-alzheimer-s-disease-through-angiotensin-ii
#20
Takashi Nakagawa, Yu Hasegawa, Ken Uekawa, Shokei Kim-Mitsuyama
Epidemiological studies suggest that chronic kidney disease (CKD) is a significant risk factor in the development of cognitive decline. However, the exact role of CKD in cognitive impairment or dementia is unclear. This work was performed to examine the potential impact of CKD on cognitive impairment in Alzheimer's disease (AD), focusing on angiotensin II. (1) CKD was induced in 5XFAD mice, an AD model mouse, and wild-type mice by feeding an adenine-containing diet and the effect on cognitive function was compared between both strains...
January 2017: Experimental Gerontology
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