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https://www.readbyqxmd.com/read/27888453/evaluation-of-nucleoside-reverse-transcriptase-inhibitor-dosing-during-continuous-veno-venous-hemofiltration
#1
Milena M McLaughlin, Inela Masic, Lana Gerzenshtein
Background Unpredictable drug concentrations may lead to suboptimal exposure to nucleoside reverse transcriptase inhibitors (NRTIs) due to inadequate doses administered during continuous veno-venous hemofiltration (CVVH), which in turn may lead to decreased antiretroviral efficacy and possibly further HIV disease progression. Objective To compare administered doses of NRTIs to calculated doses of NRTIs to evaluate if patients were expected to have a favorable pharmacokinetic exposure profile while receiving CVVH...
November 25, 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27863531/effects-of-continuous-renal-replacement-therapy-on-linezolid-pharmacokinetic-pharmacodynamics-a-systematic-review
#2
Gianluca Villa, Paola Di Maggio, A Raffaele De Gaudio, Andrea Novelli, Riccardo Antoniotti, Enrico Fiaccadori, Chiara Adembri
BACKGROUND: Major alterations in linezolid pharmacokinetic/pharmacodynamic (PK/PD) parameters might be expected in critically ill septic patients with acute kidney injury (AKI) who are undergoing continuous renal replacement therapy (CRRT). The present review is aimed at describing extracorporeal removal of linezolid and the main PK-PD parameter changes observed in critically ill septic patients with AKI, who are on CRRT. METHOD: Citations published on PubMed up to January 2016 were systematically reviewed according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement...
November 19, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27862103/pharmacokinetics-of-imipenem-cilastatin-burn-intensive-care-unit-patients-undergoing-high-dose-continuous-venovenous-hemofiltation
#3
Bradley A Boucher, Joanna Q Hudson, David M Hill, Joseph M Swanson, G Christopher Wood, S Casey Laizure, Angela Arnold-Ross, Zhe-Yi Hu, William L Hickerson
STUDY OBJECTIVE: High dose continuous venovenous hemofiltration (CVVH) is a continuous renal replacement therapy (CRRT) used frequently inpatients with burns. However, antibiotic dosing is based on inference from studies assessing substantially different methods of CRRT. To address this knowledge gap for imipenem/cilastatin (I-C) we evaluated the systemic and extracorporeal clearances (CL) of I-C in patients with burns undergoing high dose CVVH. DESIGN: Prospective clinical pharmacokinetic study...
November 9, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27861424/experimental-and-clinical-evaluation-of-pre-dilution-and-post-dilution-continuous-veno-venous-hemofiltration-on-clearance-characteristics
#4
Shinya Chihara, Yoshiki Masuda, Michiaki Yamakage
We compared the clearance characteristics of low to high molecular weight substances during pre- and post-dilution continuous veno-venous hemofiltration (CVVH) in experimental and clinical conditions.Experimental circuits for pre- and post-dilution CVVH were prepared using a test solution containing creatinine (110 Da), inulin (5,000 Da), interleukin (IL)-8 (8,000 Da), IL-6 (22,000 Da), and tumor necrosis factor (TNF)-α (51,000 Da). Quantity of test solution flow and filtration flow (QF) were set to 150 ml/min and 10, 20, and 35 ml/min, respectively...
November 16, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27851478/1843-levetiracetam-pharmacokinetics-in-a-patient-with-intracranial-hemorrhage-undergoing-cvvh
#5
Edward Van Matre, Scott Mueller, Robert Neumann, Luis Cava, Robert MacLaren, Douglas Fish, Tyree Kiser
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850954/1318-biphasic-change-in-serum-potassium-using-potassium-free-replacement-fluid-during-cvvh
#6
William Peppard, Cole Lightfoot, Corinne Bertolaccini, Barrett Mand, Thomas Carver
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850317/678-prospective-evaluation-of-a-continuous-infusion-vancomycin-nomogram-in-icu-patients-receiving-cvvh
#7
Jonathan Sin, Kelly Newman, Hsin Lin
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846630/a-first-evaluation-of-omni%C3%A2-a-new-device-for-continuous-renal-replacement-therapy
#8
Pierre Schläpfer, Jean-Daniel Durovray, Valery Plouhinec, Cristiano Chiappa, Rinaldo Bellomo, Antoine Schneider
BACKGROUND: Omni® (B. Braun, Germany) is a new-generation, continuous renal replacement therapy (CRRT) machine designed to improve user interface, minimize downtime and optimize renal dose delivery. It was never tested in humans. METHODS: We used Omni® to provide CRRT in 10 critically ill patients. We collected therapy data, metabolic parameters and evaluated user's satisfaction with a survey. RESULTS: CRRT was delivered using Omni® in CVVH-heparin (6 patients) and CVVHD-citrate (4 patients) modes for a total duration of 617...
November 16, 2016: Blood Purification
https://www.readbyqxmd.com/read/27834446/high-cut-off-hemofiltration-versus-standard-hemofiltration-effect-on-plasma-cytokines
#9
Rafidah Atan, Leah Peck, Kumar Visvanathan, Narelle Skinner, Glenn Eastwood, Rinaldo Bellomo, Markus Storr, Hermann Goehl
PURPOSE: To study the effects of continuous veno-venous hemofiltration (CVVH) with high cut-off filters (CVVH-HCO) on plasma cytokine levels, sieving coefficient and clearance compared to CVVH using standard filters (CVVH-Std) in a nested cohort within a double-blind randomized controlled trial in severe acute kidney injury (AKI) patients. METHODS: We measured plasma and post-filter levels of IL-6, TNF-alpha, IL-8, IL-1 beta, RANTES, IL-10, IFN-gamma and IFN-alpha in both study groups...
November 11, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27760529/the-effect-of-continuous-venovenous-hemofiltration-on-neutrophil-gelatinase-associated-lipocalin-plasma-levels-in-patients-with-septic-acute-kidney-injury
#10
Xingui Dai, Tao Li, Zhenhua Zeng, Chunlai Fu, Shengbiao Wang, Yeping Cai, Zhongqing Chen
BACKGROUND: It is known that continuous venonenous hemofiltration (CVVH) does not affect the plasma level of neutrophil gelatinase-associated lipocalin (pNGAL) in acute kidney injury (AKI) patients. However, because of the unique pathophysiology underlying AKI caused by sepsis, the effect of CVVH on pNGAL in this clinical setting is less certain. The purpose of this study was to determine the effect of CVVH on pNGAL in sepsis-induced AKI patients. METHODS: Between August 1, 2014, and December 31, 2014, 42 patients with sepsis-induced AKI underwent CVVH in the general intensive care unit of our institution and were consecutively enrolled in this study...
October 19, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27727794/study-of-profile-of-the-patients-suffering-from-acute-kidney-injury-being-managed-with-crrt-cvvh-in-the-icu
#11
Anup Kanwar, Satish Mendonca, Rsv Kumar
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27650232/the-reduction-rate-of-serum-sodium-and-mortality-in-patients-undergoing-continuous-venovenous-hemofiltration-for-acute-severe-hypernatremia
#12
Feng Ma, Yirong Liu, Ming Bai, Yangping Li, Yan Yu, Meilan Zhou, Pengbo Wang, Lijie He, Chen Huang, Hanmin Wang, Shiren Sun
BACKGROUND: The excessive correction of acute hypernatremia is not known to be harmful. This study aimed to evaluate whether a reduction rate of serum sodium (RRSeNa) > 1mEq/L/hour in acute severe hypernatremia is an independent risk factor for mortality in critically ill patients undergoing continuous venovenous hemofiltration (CVVH) treatment. MATERIALS AND METHODS: For this retrospective study, we reviewed records of 75 critically ill patients undergoing CVVH treatment for acute severe hypernatremia between March 2011 and March 2015...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27612461/the-effects-of-early-high-volume-hemofiltration-on-prolonged-cardiac-arrest-in-rats-with-reperfusion-by-cardiopulmonary-bypass-a-randomized-controlled-animal-study
#13
Koichiro Shinozaki, Joshua W Lampe, Junhwan Kim, Tai Yin, Tong Da, Shigeto Oda, Hiroyuki Hirasawa, Lance B Becker
BACKGROUND: It is not yet clear whether hemofiltration can reduce blood cytokine levels sufficiently to benefit patients who suffer prolonged cardiac arrest (CA) treated with cardiopulmonary bypass (CPB). We sought to assess effects of high-volume and standard volume continuous veno-venous hemofiltration (CVVH) on blood cytokine levels and survival in a rat model of prolonged CA treated with CPB. METHODS: Sprague-Dawley male rats were subjected to 12 min of asphyxia to induce CA...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27562561/chloride-content-of-solutions-used-for-regional-citrate-anticoagulation-might-be-responsible-for-blunting-correction-of-metabolic-acidosis-during-continuous-veno-venous-hemofiltration
#14
Rita Jacobs, Patrick M Honore, Marc Diltoer, Herbert D Spapen
BACKGROUND: Citrate, the currently preferred anticoagulant for continuous veno-venous hemofiltration (CVVH), may influence acid-base equilibrium. METHODS: The effect of 2 different citrate solutions on acid-base status was assessed according to the Stewart-Figge approach in two consecutive cohorts of critically ill adult patients. The first group received Prismocitrate 10/2 (PC10/2; 10 mmol citrate/L). The next group was treated with Prismocitrate 18/0 (PC18; 18 mmol citrate/L)...
2016: BMC Nephrology
https://www.readbyqxmd.com/read/27494946/population-pharmacokinetics-of-cefuroxime-in-critically-ill-patients-receiving-continuous-venovenous-hemofiltration-with-regional-citrate-anticoagulation-and-a-phosphate-containing-replacement-fluid
#15
Paddy K C Janssen, Norbert A Foudraine, Desirée M T Burgers, Kees Neef, Jos L M L le Noble
BACKGROUND: Cefuroxime is frequently prescribed as an antimicrobial therapy in critically ill patients. The aim of this study was to develop a new intravenous dosing strategy for cefuroxime in critically ill patients undergoing continuous venovenous hemofiltration with regional citrate anticoagulation (RCA-CVVH) by analyzing its extracorporeal removal and pharmacokinetic (PK) parameters. METHODS: Nine critically ill patients treated with intravenous cefuroxime and RCA-CVVH and a phosphate-containing replacement fluid were investigated...
December 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27434561/-the-influence-of-continuous-veno-venous-hemofiltration-on-cardiac-output-value-monitored-by-transpulmonary-thermodilution-technique-in-critical-patients
#16
Hong Mei, Miao Chen, Xiaoyun Fu, Kang Li, Guoyue Liu, Song Qin
OBJECTIVE: To investigate the influence of continuous veno-venous hemofiltration (CVVH) on cardiac output (CO) value and parameters of hemodynamics monitored by transpulmonary thermodilution technique in critical patients. METHODS: A prospective cohort study was conduced. Sixty-two critical patients admitted to intensive care unit (ICU) of Zunyi Medical College Affiliated Hospital from January 2011 to October 2015 were enrolled. All of the patients received CVVH through femoral vein puncture catheter...
August 2016: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27424534/extracorporeal-treatments-in-a-dapsone-overdose-a-case-report
#17
Marc Ghannoum, Monique Cormier, Amélie Bernier-Jean, Dave Brindamour, Clément Déziel, Josée Bouchard
INTRODUCTION: Intentional dapsone intoxication can be life-threatening. There is limited data on the clinical effect of extracorporeal treatments (ECTRs) on dapsone elimination. We describe a case of severe dapsone toxicity treated with different ECTRs. CASE DETAILS: A 23-year-old woman was admitted 2.5 h after ingesting 2.2 g of dapsone. She developed methemoglobinemia (39.9%) and showed signs of toxicity (hemodynamic instability and altered mental status) despite multiple-activated charcoal, methylene blue, vasopressors and endotracheal intubation...
July 18, 2016: Clinical Toxicology
https://www.readbyqxmd.com/read/27411455/determinants-of-calcium-infusion-rate-during-continuous-veno-venous-hemofiltration-with-regional-citrate-anticoagulation-in-critically-ill-patients-with-acute-kidney-injury
#18
De-Lin Liu, Li-Feng Huang, Wen-Liang Ma, Qi Ding, Yue Han, Yue Zheng, Wen-Xiong Li
BACKGROUND: It is unclear that how to decide the calcium infusion rate during continuous veno-venous hemofiltration (CVVH) with regional citrate anticoagulation (RCA). This study aimed to assess the determinants of calcium infusion rate during CVVH with RCA in critically ill patients with acute kidney injury (AKI). METHODS: A total of 18 patients with AKI requiring CVVH were prospectively analyzed. Postdilution CVVH was performed with a fixed blood flow rate of 150 ml/min and a replacement fluid flow rate of 2000 ml/h for each new circuit...
July 20, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27391086/kinetics-of-linezolid-in-continuous-renal-replacement-therapy-an-in-vitro-study
#19
Marco Sartori, Arianna Loregian, Silvana Pagni, Silvia De Rosa, Fiorenza Ferrari, Leopolda Zampieri, Mirella Zancato, Giorgio Palú, Claudio Ronco
BACKGROUND: Continuous veno-venous hemofiltration (CVVH) could affect the pharmacokinetic profile of linezolid (LZD). The aim of this study was to evaluate the LZD extracorporeal clearance using an in vitro CVVH model. METHODS: A sham miniaturized CVVH circuit (CARPEDIEM; Bellco, Mirandola, Italy) was set up with a polysulfone hemofilter (0.25 m; cutoff 50,000 Da) for 240 minutes using normal saline solution (0.9% wt/vol NaCl) and blood (n = 6) spiked with LZD. Drug solution samples were collected during CVVH at 10, 30, 60, 120, and 240 minutes...
October 2016: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/27358135/vena-venous-hemofiltration-in-treating-severe-injury-induced-multiple-organ-dysfunction-syndrome
#20
Y Fang, H L Zong, L Zhang, Z H Wang, L M Sun, R F Zhang
Severe multiple injury (SMI) can induce multiple organ dysfunction syndrome (MODS) and easily result in complications, as well as having a high mortality rate. To explore the curative effect of continuous vena-venous hemofiltration (CVVH) in treating MODS and its effect on serum tumor necrosis factor (TNF)-α interleukin (IL)-10 and nitric oxide (NO), we selected 200 patients who suffered from SMI and received treatment in the First Affiliated Hospital of Zhengzhou University between April 2012 and April 2014 as research subjects...
April 2016: Journal of Biological Regulators and Homeostatic Agents
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