Saskia Räuber, Christina B Schroeter, Christine Strippel, Christopher Nelke, Tillmann Ruland, Andre Dik, Kristin S Golombeck, Liesa Regner-Nelke, Manuela Paunovic, Daniela Esser, Christian Münch, Felix Rosenow, Martijn van Duijn, Antonia Henes, Tobias Ruck, Ido Amit, Frank Leypoldt, Maarten J Titulaer, Heinz Wiendl, Sven G Meuth, Gerd Meyer Zu Hörste, Nico Melzer
Autoimmune Encephalitis (AE) spans a group of non-infectious inflammatory conditions of the central nervous system due to an imbalanced immune response. Aiming to elucidate the pathophysiological mechanisms of AE, we applied an unsupervised proteomic approach to analyze the cerebrospinal fluid (CSF) protein profile of AE patients with autoantibodies against N-methyl-d-aspartate receptor (NMDAR) (n = 9), leucine-rich glioma-inactivated protein 1 (LGI1) (n = 9), or glutamate decarboxylase 65 (GAD65) (n = 8) compared to 9 patients with relapsing-remitting multiple sclerosis as inflammatory controls, and 10 patients with somatic symptom disorder as non-inflammatory controls...
February 2023: Journal of Autoimmunity