Karishma Kalera, Rachel Liu, Juhyeon Lim, Rasangi Pathirage, Daniel H Swanson, Ulysses G Johnson, Alicyn I Stothard, Jae Jin Lee, Anne W Poston, Peter J Woodruff, Donald R Ronning, Hyungjin Eoh, Benjamin M Swarts
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the leading cause of death worldwide by infectious disease. Treatment of Mtb infection requires a six-month course of multiple antibiotics, an extremely challenging regimen necessitated by Mtb's ability to form drug-tolerant persister cells. Mtb persister formation is dependent on the trehalose catalytic shift, a stress-responsive metabolic remodeling mechanism in which the disaccharide trehalose is liberated from cell surface glycolipids and repurposed as an internal carbon source to meet energy and redox demands...
March 14, 2024: ACS Infectious Diseases