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https://www.readbyqxmd.com/read/28212991/different-histological-subtypes-of-peripheral-lung-cancer-based-on-emphysema-distribution-in-patients-with-both-airflow-limitation-and-ct-determined-emphysema
#1
Beomsu Shin, Sumin Shin, Myung Jin Chung, Hyun Lee, Won-Jung Koh, Hojoong Kim, Hye Yun Park
The histological subtypes by peripheral tumor location remain uncharacterized in COPD patients with emphysema. We investigated histologic subtypes of peripheral lung cancers based on the context of heterogeneous emphysema distribution in patients with airflow limitation and CT-determined emphysema. A retrospective, cross-sectional study was conducted using data from 754 patients with airflow limitation and newly-diagnosed primary lung cancers from February 2013 to February 2015. Of these, 230 patients had emphysema, as determined by computed tomography software designed to quantify emphysema...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28212575/upregulation-of-mucin-glycoprotein-muc1-in-the-progression-to-esophageal-adenocarcinoma-and-therapeutic-potential-with-a-targeted-photoactive-antibody-drug-conjugate
#2
Mohammed Adil Butt, Hayley Pye, Rehan J Haidry, Dahmane Oukrif, Saif-U-Rehman Khan, Ignazio Puccio, Michael Gandy, Halla W Reinert, Ellie Bloom, Mohammed Rashid, Gokhan Yahioglu, Mahendra P Deonarain, Rifat Hamoudi, Manuel Rodriguez-Justo, Marco R Novelli, Laurence B Lovat
BACKGROUND: Mucin glycoprotein 1 (MUC1) is a glycosylated transmembrane protein on epithelial cells. We investigate MUC1 as a therapeutic target in Barrett's epithelium (BE) and esophageal adenocarcinoma (EA) and provide proof of concept for a light based therapy targeting MUC1. RESULTS: MUC1 was present in 21% and 30% of significantly enriched pathways comparing BE and EA to squamous epithelium respectively. MUC1 gene expression was x2.3 and x2.2 higher in BE (p=<0...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212421/a-low-cost-dac-bist-structure-using-a-resistor-loop
#3
Jaewon Jang, Heetae Kim, Sungho Kang
This paper proposes a new DAC BIST (digital-to-analog converter built-in self-test) structure using a resistor loop known as a DDEM ADC (deterministic dynamic element matching analog-to-digital converter). Methods for both switch reduction and switch effect reduction are proposed for solving problems related to area overhead and accuracy of the conventional DAC BIST. The proposed BIST modifies the length of each resistor in the resistor loop via a merging operation and reduces the number of switches and resistors...
2017: PloS One
https://www.readbyqxmd.com/read/28211619/intravoxel-incoherent-motion-diffusion-weighted-imaging-of-bone-marrow-in-patients-with-acute-myeloid-leukemia-a-pilot-study-of-prognostic-value
#4
Jinliang Niu, Wenjin Li, Hongwei Wang, Wenqi Wu, Tong Gong, Ning Huang, Jun Wang, Yan Qi
PURPOSE: To investigate the value of intravoxel incoherent motion (IVIM) parameters in evaluation of prognosis in patients with acute myeloid leukemia (AML) before treatment. MATERIALS AND METHODS: Fifty-three patients before standard chemotherapy underwent MRI scans at 1.5 Tesla using conventional diffusion weighted imaging (DWI) and IVIM (b = 0, 10, 25, 50, 100, 200, 400, 600, 800, 1000, 1200 s/mm(2) ) in the sagittal plane covering the lumbar bone marrow...
February 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28211277/antineoplastic-agents-603-quinstatins-exceptional-cancer-cell-growth-inhibitors
#5
George R Pettit, Noeleen Melody, Jean-Charles Chapuis
Discovery of the exceptionally powerful anticancer drug dolastatin 10 (1), contained in the sea hare Dolabella auricularia, opened a new frontier needed for improving human cancer treatment. Subsequently, major advances have been achieved based on results of structurally modifying this unusual natural peptide while maintaining the remarkable anticancer activity necessary for preparation of successful monoclonal antibody drug conjugates (ADC). Among the first several hundred SAR products based on dolastatin 10 our group synthesized and termed auristatins was auristatin E (2a)...
February 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28210802/poorly-differentiated-colorectal-neuroendocrine-tumour-ct-differentiation-from-well-differentiated-neuroendocrine-tumour-and-poorly-differentiated-adenocarcinomas
#6
Ji Hee Kang, Se Hyung Kim, Joon Koo Han
OBJECTIVE: The differentiation of poorly-differentiated neuroendocrine tumours (PD-NETs), well-differentiated NETs (WD-NETs), and adenocarcinomas (ADCs) is important due to different management options and prognoses. This study is to find the differential CT features of colorectal PD-NETs from WD-NETs and ADCs. MATERIALS AND METHODS: CT features of 25 colorectal WD-NETs, 36 PD-NETs, and 36 ADCs were retrospectively reviewed. Significant variables were assessed using univariate and multivariate analyses...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28210496/the-additional-utility-of-apparent-diffusion-coefficient-values-of-clear-cell-renal-cell-carcinoma-for-predicting-metastasis-during-clinical-staging
#7
Rika Yoshida, Takeshi Yoshizako, Araki Hisatoshi, Hiroshi Mori, Yukihisa Tamaki, Noriyoshi Ishikawa, Hajime Kitagaki
BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RCC by comparing ADC values between groups with T1a RCC (tumor size ≤ 4 cm) without metastasis and the group with metastasis. MATERIAL AND METHODS: A retrospective review was performed on 51 patients with 51 RCCs who underwent 1...
January 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28209583/combining-diffusion-tensor-metrics-and-dsc-perfusion-imaging-can-it-improve-the-diagnostic-accuracy-in-differentiating-tumefactive-demyelination-from-high-grade-glioma
#8
S B Hiremath, A Muraleedharan, S Kumar, C Nagesh, C Kesavadas, M Abraham, T R Kapilamoorthy, B Thomas
BACKGROUND AND PURPOSE: Tumefactive demyelinating lesions with atypical features can mimic high-grade gliomas on conventional imaging sequences. The aim of this study was to assess the role of conventional imaging, DTI metrics (p:q tensor decomposition), and DSC perfusion in differentiating tumefactive demyelinating lesions and high-grade gliomas. MATERIALS AND METHODS: Fourteen patients with tumefactive demyelinating lesions and 21 patients with high-grade gliomas underwent brain MR imaging with conventional, DTI, and DSC perfusion imaging...
February 16, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28208155/pet-mr-in-invasive-ductal-breast-cancer-correlation-between-imaging-markers-and-histological-phenotype
#9
Onofrio Antonio Catalano, Gary Lloyd Horn, Alberto Signore, Carlo Iannace, Maria Lepore, Mark Vangel, Angelo Luongo, Marco Catalano, Constance Lehman, Marco Salvatore, Andrea Soricelli, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
BACKGROUND: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. METHODS: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28207858/non-small-cell-lung-cancer-whole-lesion-histogram-analysis-of-the-apparent-diffusion-coefficient-for-assessment-of-tumor-grade-lymphovascular-invasion-and-pleural-invasion
#10
Naoko Tsuchiya, Mariko Doai, Katsuo Usuda, Hidetaka Uramoto, Hisao Tonami
PURPOSE: Investigating the diagnostic accuracy of histogram analyses of apparent diffusion coefficient (ADC) values for determining non-small cell lung cancer (NSCLC) tumor grades, lymphovascular invasion, and pleural invasion. MATERIALS AND METHODS: We studied 60 surgically diagnosed NSCLC patients. Diffusion-weighted imaging (DWI) was performed in the axial plane using a navigator-triggered single-shot, echo-planar imaging sequence with prospective acquisition correction...
2017: PloS One
https://www.readbyqxmd.com/read/28207745/evolution-of-blood-brain-barrier-permeability-after-acute-ischemic-stroke
#11
Zamir Merali, Kun Huang, David Mikulis, Frank Silver, Andrea Kassner
The dynamics of BBB permeability after AIS in humans are not well understood. In the present study we measured the evolution of BBB permeability after AIS in humans using MRI. Patients presenting to our institution with a diagnosis of AIS underwent a single dynamic contrast-enhanced MRI (DCE-MRI) sequence to measure BBB permeability during their initial workup. Forty-two patients were included in the final analysis. The patient sample underwent DCE-MRI at a mean time of 23.8hrs after the onset of AIS symptoms (range: 1...
2017: PloS One
https://www.readbyqxmd.com/read/28207659/evaluation-of-dti-parameter-ratios-and-diffusion-tensor-tractography-grading-in-the-diagnosis-and-prognosis-prediction-of-cervical-spondylotic-myelopathy
#12
Kun Wang, Zhi Chen, Fan Zhang, Qingxin Song, Canglong Hou, Yixing Tang, Jun Wang, Shiyue Chen, Yun Bian, Qiang Hao, Hongxing Shen
STUDY DESIGN: Prospective cohort. OBJECTIVE: To explore the correlations between diffusion tensor imaging (DTI) ratios and diffusion tensor tractography (DTT) grading with clinical symptoms and outcomes of cervical spondylotic myelopathy (CSM). SUMMARY OF BACKGROUND DATA: In addition to magnetic resonance imaging (MRI) and computed tomography, DTI may be useful in understanding pathophysiology of spinal cord in earlier stages of the CSM but it may be confounded by age and cervical level, and previous studies had small sample sizes...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28199367/evaluation-of-different-mathematical-models-and-different-b-value-ranges-of-diffusion-weighted-imaging-in-peripheral-zone-prostate-cancer-detection-using-b-value-up-to-4500-s-mm2
#13
Zhaoyan Feng, Xiangde Min, Daniel J A Margolis, Caohui Duan, Yuping Chen, Vivek Kumar Sah, Nabin Chaudhary, Basen Li, Zan Ke, Peipei Zhang, Liang Wang
OBJECTIVES: To evaluate the diagnostic performance of different mathematical models and different b-value ranges of diffusion-weighted imaging (DWI) in peripheral zone prostate cancer (PZ PCa) detection. METHODS: Fifty-six patients with histologically proven PZ PCa who underwent DWI-magnetic resonance imaging (MRI) using 21 b-values (0-4500 s/mm2) were included. The mean signal intensities of the regions of interest (ROIs) placed in benign PZs and cancerous tissues on DWI images were fitted using mono-exponential, bi-exponential, stretched-exponential, and kurtosis models...
2017: PloS One
https://www.readbyqxmd.com/read/28199096/why-porous-materials-have-selective-adsorptions-a-rational-aspect-from-electrodynamics
#14
Qiang Chen, Yuguang Ma, Wei-Chao Song, Ze Chang, Jian-Rong Li, Jun Zhang, Hong-Wei Sun, Perla B Balbuena, Xian-He Bu
Gas storage/separation is a typical application of porous materials such as metal organic frameworks (MOFs). The adsorption/separation behavior results from the host-guest and/or guest-guest interaction and equilibration (host, porous material; guest, adsorbates). Although the driving forces for gas adsorption have been investigated, a detailed picture of interactions between gas molecules and MOFs has not clearly emerged. Herein, a new cobalt microporous MOF [Co(tipb)(adc)](DMF)3(H2O)1.5, which possesses a rare self-interpenetrated gra topology, has been prepared with both tipb and H2adc ligands (tipb = 1,3,5-tris(p-imidazolylphenyl)benzene, adc = 9,10-anthracenedicarboxylate)...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28199041/feasibility-of-accelerated-simultaneous-multislice-diffusion-weighted-mri-of-the-prostate
#15
Jakob Weiss, Petros Martirosian, Jana Taron, Ahmed E Othman, Thomas Kuestner, Michael Erb, Jens Bedke, Fabian Bamberg, Konstantin Nikolaou, Mike Notohamiprodjo
PURPOSE: To assess the feasibility of simultaneous multislice (SMS) single-shot echo-planar-imaging (EPI) for accelerated diffusion-weighted imaging (DWI) of the prostate. MATERIALS AND METHODS: For phantom measurements a dedicated DWI phantom with different sucrose concentrations was used. In addition, 10 volunteers and 16 patients with suspected prostate cancer were examined for in vivo measurements. All examinations were performed with a 3T magnetic resonance imaging (MRI) system...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28199039/radiomics-assessment-of-bladder-cancer-grade-using-texture-features-from-diffusion-weighted-imaging
#16
Xi Zhang, Xiaopan Xu, Qiang Tian, Baojuan Li, Yuxia Wu, Zengyue Yang, Zhengrong Liang, Yang Liu, Guangbin Cui, Hongbing Lu
PURPOSE: To 1) describe textural features from diffusion-weighted images (DWI) and apparent diffusion coefficient (ADC) maps that can distinguish low-grade bladder cancer from high-grade, and 2) propose a radiomics-based strategy for cancer grading using texture features. MATERIALS AND METHODS: In all, 61 patients with bladder cancer (29 in high- and 32 in low-grade groups) were enrolled in this retrospective study. Histogram- and gray-level co-occurrence matrix (GLCM)-based radiomics features were extracted from cancerous volumes of interest (VOIs) on DWI and corresponding ADC maps of each patient acquired from 3...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28195509/reduced-subarachnoid-fluid-diffusion-in-enlarged-subarachnoid-spaces-of-infancy
#17
Matthew T Whitehead, Bonmyong Lee, Audrey McCarron, Stanley T Fricke, Gilbert Vezina
Background and purpose Enlargement of the subarachnoid spaces in infancy (ESSI) is a common cause of macrocephaly without proven explanation. We have observed subarachnoid diffusion to be decreased in these patients. We aim to quantify the diffusivity of ventricular and subarachnoid cerebrospinal fluid in ESSI patients, to determine if diffusion characteristics deviate from normocephalic infants, and to propose a unique mechanism for ESSI. Materials and methods 227 consecutive brain magnetic resonance exams from different macrocephalic children were retrospectively reviewed after institutional review board waiver...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28194947/derivation-of-the-statistical-distribution-of-the-mass-peak-centroids-of-mass-spectrometers-employing-analog-to-digital-converters-and-electron-multipliers
#18
Andreas Ipsen
The mass peak centroid is a quantity that is at the core of mass spectrometry (MS). However, despite its central status in the field, models of its statistical distribution are often chosen quite arbitrarily and without attempts at establishing a proper theoretical justification for their use. Recent work has demonstrated that for mass spectrometers employing analog-to-digital converters (ADCs) and electron multipliers, the statistical distribution of the mass peak intensity can be described via a relatively simple model derived essentially from first principles...
February 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191936/development-of-fluorophore-labeled-thailanstatin-antibody-drug-conjugates-for-cellular-trafficking-studies
#19
Chethana Kulkarni, James E Finley, Andrew J Bessire, Xiaotian Zhong, Sylvia Musto, Edmund Idris Graziani
As the antibody-drug conjugate (ADC) field grows increasingly important for cancer treatment, it is vital for researchers to establish a firm understanding of how ADCs function at the molecular level. To gain insight into ADC uptake, trafficking, and catabolism-processes that are critical to ADC efficacy and toxicity-imaging studies have been performed with fluorophore-labeled conjugates. However, such labels may alter the properties and behavior of the ADC under investigation. As an alternative approach, we present here the development of a "clickable" ADC bearing an azide-functionalized linker-payload (LP) poised for "click" reaction with alkyne fluorophores; the azide group represents a significantly smaller structural perturbation to the LP than most fluorophores...
February 13, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28190854/evaluation-of-diffusion-weighted-mr-imaging-as-a-technique-for-detecting-bone-marrow-edema-in-patients-with-osteitis-pubis
#20
Iclal Erdem Toslak, Bulent Cekic, Aysen Turk, Ali Eraslan, A Eda Parlak
PURPOSE: Our aims were to determine the feasibility of diffusion-weighted magnetic resonance imaging (DWI) in the detection of bone marrow edema (BME) and explore the apparent diffusion coefficient (ADC) alterations in patients with osteitis pubis (OP). MATERIALS AND METHODS: Fourty two consecutive patients clinically suspected to have athletic pubalgia and 31 control subjects were enrolled in the study. All subjects underwent diagnostic focused magnetic resonance imaging (MRI) and DWI at b values of 0 and 600 s/mm(2)...
February 13, 2017: Magnetic Resonance in Medical Sciences: MRMS
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