Kathryn J Schunke, Jeannette Rodriguez, Jhansi Dyavanapalli, John Schloen, Xin Wang, Joan Escobar, Grant Kowalik, Emily C Cheung, Caitlin Ribeiro, Rebekah Russo, Bridget R Alber, Olga Dergacheva, Sheena W Chen, Alejandro E Murillo-Berlioz, Kyongjune B Lee, Gregory Trachiotis, Emilia Entcheva, Christine A Brantner, David Mendelowitz, Matthew W Kay
Altered autonomic balance is a hallmark of numerous cardiovascular diseases, including myocardial infarction (MI). Although device-based vagal stimulation is cardioprotective during chronic disease, a non-invasive approach to selectively stimulate the cardiac parasympathetic system immediately after an infarction does not exist and is desperately needed. Cardiac vagal neurons (CVNs) in the brainstem receive powerful excitation from a population of neurons in the paraventricular nucleus (PVN) of the hypothalamus that co-release oxytocin (OXT) and glutamate to excite CVNs...
October 6, 2023: Basic Research in Cardiology