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https://www.readbyqxmd.com/read/29180673/calhm2-governs-astrocytic-atp-releasing-in-the-development-of-depression-like-behaviors
#1
M Jun, Q Xiaolong, Y Chaojuan, P Ruiyuan, W Shukun, W Junbing, H Li, C Hong, C Jinbo, W Rong, L Yajin, M Lanqun, W Fengchao, W Zhiying, A Jianxiong, W Yun, Z Xia, Z Chen, Y Zengqiang
Extracellular ATP is a widespread cell-to-cell signaling molecule in the brain, where it functions as a neuromodulator by activating glia and neurons. Although ATP exerts multiple effects on synaptic plasticity and neuro-glia interactions, as well as in mood disorders, the source and regulation of ATP release remain to be elaborated. Here, we define Calhm2 as an ATP-releasing channel protein based on in vitro and in vivo models. Conventional knockout and conditional astrocyte knockout of Calhm2 both lead to significantly reduced ATP concentrations, loss of hippocampal spine number, neural dysfunction and depression-like behaviors in mice, which can be significantly rescued by ATP replenishment...
November 28, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29061403/neuroleptic-malignant-syndrome-a-neuro-psychiatric-emergency-recognition-prevention-and-management
#2
REVIEW
Raj Velamoor
Neuroleptic Malignant Syndrome (NMS) is a life threatening complication of antipsychotic therapy. It is often assumed to be rare. Observations suggest that rather than overestimating its frequency, we are more likely to underestimate it (Pope et al., 1986). It is a rare but potentially fatal disorder characterized by four principal symptoms. These are mental status changes, muscle rigidity, hyperthermia, and autonomic dysfunction. The diagnosis of NMS often presents a challenge because several medical conditions generate similar symptoms...
October 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28894299/dhea-inhibits-acute-microglia-mediated-inflammation-through-activation-of-the-trka-akt1-2-creb-jmjd3-pathway
#3
V I Alexaki, G Fodelianaki, A Neuwirth, C Mund, A Kourgiantaki, E Ieronimaki, K Lyroni, M Troullinaki, C Fujii, W Kanczkowski, A Ziogas, M Peitzsch, S Grossklaus, B Sönnichsen, A Gravanis, S R Bornstein, I Charalampopoulos, C Tsatsanis, T Chavakis
Dehydroepiandrosterone (DHEA) is the most abundant circulating steroid hormone in humans, produced by the adrenals, the gonads and the brain. DHEA was previously shown to bind to the nerve growth factor receptor, tropomyosin-related kinase A (TrkA), and to thereby exert neuroprotective effects. Here we show that DHEA reduces microglia-mediated inflammation in an acute lipopolysaccharide-induced neuro-inflammation model in mice and in cultured microglia in vitro. DHEA regulates microglial inflammatory responses through phosphorylation of TrkA and subsequent activation of a pathway involving Akt1/Akt2 and cAMP response element-binding protein...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28866901/anxiety-and-psychosomatic-symptoms-in-palliative-care-from-neuro-psychobiological-response-to-stress-to-symptoms-management-with-clinical-hypnosis-and-meditative-states
#4
Anirudh Kumar Satsangi, Maria Paola Brugnoli
Psychosomatic disorder is a condition in which psychological stresses adversely affect physiological (somatic) functioning to the point of distress. It is a condition of dysfunction or structural damage in physical organs through inappropriate activation of the involuntary nervous system and the biochemical response. In this framework, this review will consider anxiety disorders, from the perspective of the psychobiological mechanisms of vulnerability to extreme stress in severe chronic illnesses. Psychosomatic medicine is a field of behavioral medicine and a part of the practice of consultation-liaison psychiatry...
August 9, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/28803680/corrigendum-to-analysis-of-association-between-common-snps-in-erbb4-and-bipolar-affective-disorder-major-depressive-disorder-and-schizophrenia-in-the-han-chinese-population-prog-neuro-psychopharmacol-biol-psychiatry-36-2012-17-21
#5
P Chen, J Chen, K Huang, W Ji, T Wang, T Li, Y Wang, H Wang, L He, G Feng, Y Shi
No abstract text is available yet for this article.
August 10, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28732736/corrigendum-to-reproductive-steroid-receptors-and-actions-in-the-locus-coeruleus-of-male-macaques-part-of-an-aggression-circuit-prog-neuro-psychopharmacol-biol-psychiatry-71-2016-210-222
#6
Cynthia L Bethea, Yelena Belikova, Kenny Phu, Grace Mammarella
No abstract text is available yet for this article.
July 18, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28714607/new-insights-into-how-serotonin-selective-reuptake-inhibitors-shape-the-developing-brain
#7
REVIEW
Jay A Gingrich, Heli Malm, Mark S Ansorge, Alan Brown, Andre Sourander, Deepika Suri, Cátia M Teixeira, Martha K Caffrey Cagliostro, Darshini Mahadevia, Myrna M Weissman
Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system (CNS) development, such sensitive periods shape the formation of neuro-circuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint, as well as the environmental context. While allowing for adaptation, such sensitive periods are also windows of vulnerability during which external and internal factors can confer risk to brain disorders by derailing adaptive developmental programs...
July 17, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/28659239/a-causality-algorithm-to-guide-diagnosis-and-treatment-of-catatonia-due-to-autoimmune-conditions-in-children-and-adolescents
#8
Vladimir Ferrafiat, Marie Raffin, Elena Freri, Tiziana Granata, Nardo Nardocci, Federica Zibordi, Nicolas Bodeau, Xavier Benarous, Bertrand Olliac, Elise Riquin, Jean Xavier, Sylvie Viaux, Julien Haroche, Zahir Amoura, Priscille Gerardin, David Cohen, Angèle Consoli
OBJECTIVES: Pediatric catatonia is a rare and life-threatening syndrome. Around 20% of juvenile catatonia is associated with organic condition (Consoli et al., 2012). Autoimmune conditions represent a diagnostic and therapeutic challenge since specific antibodies can be missed. To facilitate decision making, we recently formulated a causality assessment score (CAUS) using a stepwise approach and an immunosuppressive therapeutic challenge (Ferrafiat et al., 2016). Our objectives were to validate retrospectively CAUS and to define its threshold for an accurate distinction between organic catatonia and non-organic catatonia, and specifically between autoimmune catatonia and non-organic catatonia...
June 25, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28446210/cognitive-changes-in-alcohol-induced-psychotic-disorder
#9
Melany L Hendricks, R A Emsley, D G Nel, H B Thornton, G P Jordaan
AIMS: This study aimed to explore the neuro-cognitive deficits of alcohol-induced psychotic disorder as compared to the cognitive deficits of uncomplicated alcohol dependence. METHODS: Participants were recruited from the acute psychiatric admission wards of the Department of Psychiatry, University of Stellenbosch and Stikland and Tygerberg Academic Hospitals in the Western-Cape, South Africa. Participants who met DSM IV TR criteria (American Psychiatric Association...
April 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28423808/security-policy-and-infrastructure-in-the-context-of-a-multi-centeric-information-system-dedicated-to-autism-spectrum-disorder
#10
Mohamed Ben Said, Laurence Robel, Bernard Golse, Jean Philippe Jais
Autism spectrum disorders (ASD) are complex neuro-developmental disorders affecting children in their early age. The diagnosis of ASD relies on multidisciplinary investigations, in psychiatry, neurology, genetics, electrophysiology, neuro-imagery, audiology and ophthalmology. In order to support clinicians, researchers and public health decision makers, we designed an information system dedicated to ASD, called TEDIS. TEDIS was designed to manage systematic, exhaustive and continuous multi-centric patient data collection via secured Internet connections...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28110862/corrigendum-to-hallucinatory-experience-as-aberrant-event-memory-formation-implications-for-the-pathophysiology-of-schizophrenia-prog-neuro-psychopharmacol-biol-psychiatry-71-2016-203-209
#11
Ralf-Peter Behrendt
No abstract text is available yet for this article.
April 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28063470/corrigendum-to-the-use-of-cannabinoids-as-anticancer-agents-prog-neuro-psychopharmacol-biol-psychiatry-64-2016-259-266
#12
Guillermo Velasco, Sonia Hernández-Tiedra, David Dávila, Mar Lorente
No abstract text is available yet for this article.
March 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27975358/-music-in-health-promotion-and-therapeutic-practice-cultural-theoretical-and-clinical-perspectives
#13
REVIEW
Wolfgang Mastnak
Music can serve as a shelter and music therapy can provide spaces for symbolic experience and the modification of behavioural and cognitive patterns. Explaining the power of music, ancient theories speak of an analogy between music and man. Similar views are also found in modern music therapy such as Sound Work, a voice-body-based model. Complementary to the aspect of analogy, the principle of transformation is of vital importance, such as the transitions between the five elements, the solid organs and the pentatonic scale in Chinese music therapy, for instance...
December 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27672371/the-semiology-of-motor-disorders-in-autism-spectrum-disorders-as-highlighted-from-a-standardized-neuro-psychomotor-assessment
#14
Aude Paquet, Bertrand Olliac, Manuel-Pierre Bouvard, Bernard Golse, Laurence Vaivre-Douret
BACKGROUND: Altered motor performance has been described in Autism Spectrum Disorders (ASD) with disturbances in walking; posture, coordination, or arm movements, but some individuals with ASD show no impairment of motor skills. The neuro-developmental processes that underpin the performance of neuro-psychomotor functions have not been widely explored, nor is it clear whether there are neuro-psychomotor functions specifically affected in ASD. Our objective was to focus on the semiology of motor disorders among children with ASD using a neuro-developmental assessment tool...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27522011/unconscious-emotion-a-cognitive-neuroscientific-perspective
#15
REVIEW
Ryan Smith, Richard D Lane
While psychiatry and clinical psychology have long discussed the topic of unconscious emotion, and its potentially explanatory role in psychopathology, this topic has only recently begun to receive attention within cognitive neuroscience. In contrast, neuroscientific research on conscious vs. unconscious processes within perception, memory, decision-making, and cognitive control has seen considerable advances in the last two decades. In this article, we extrapolate from this work, as well as from recent neural models of emotion processing, to outline multiple plausible neuro-cognitive mechanisms that may be able to explain why various aspects of one's own emotional reactions can remain unconscious in specific circumstances...
October 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27280523/efficacy-and-feasibility-of-the-integrated-psychological-therapy-for-outpatients-with-schizophrenia-in-greece-final-results-of-a-rct
#16
RANDOMIZED CONTROLLED TRIAL
Stavroula Rakitzi, Polyxeni Georgila, Konstantinos Efthimiou, Daniel R Mueller
The goal of this study was to evaluate the efficacy and the feasibility of cognitive remediation group therapy in patients with schizophrenia in Greece. For this purpose, the cognitive part of the Integrated Psychological Therapy (IPT), focusing on neuro- and social cognition, was compared in a randomized controlled trial (RCT) with treatment as usual (TAU). 48 outpatients took part in the study. IPT groups received 20 biweekly 1-h-therapy sessions. A test-battery was assessed at baseline, after therapy, and at a 3-month follow-up...
August 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27137745/cortical-abnormalities-in-adults-and-adolescents-with-major-depression-based-on-brain-scans-from-20-cohorts-worldwide-in-the-enigma-major-depressive-disorder-working-group
#17
L Schmaal, D P Hibar, P G Sämann, G B Hall, B T Baune, N Jahanshad, J W Cheung, T G M van Erp, D Bos, M A Ikram, M W Vernooij, W J Niessen, H Tiemeier, A Hofman, K Wittfeld, H J Grabe, D Janowitz, R Bülow, M Selonke, H Völzke, D Grotegerd, U Dannlowski, V Arolt, N Opel, W Heindel, H Kugel, D Hoehn, M Czisch, B Couvy-Duchesne, M E Rentería, L T Strike, M J Wright, N T Mills, G I de Zubicaray, K L McMahon, S E Medland, N G Martin, N A Gillespie, R Goya-Maldonado, O Gruber, B Krämer, S N Hatton, J Lagopoulos, I B Hickie, T Frodl, A Carballedo, E M Frey, L S van Velzen, B W J H Penninx, M-J van Tol, N J van der Wee, C G Davey, B J Harrison, B Mwangi, B Cao, J C Soares, I M Veer, H Walter, D Schoepf, B Zurowski, C Konrad, E Schramm, C Normann, K Schnell, M D Sacchet, I H Gotlib, G M MacQueen, B R Godlewska, T Nickson, A M McIntosh, M Papmeyer, H C Whalley, J Hall, J E Sussmann, M Li, M Walter, L Aftanas, I Brack, N A Bokhan, P M Thompson, D J Veltman
The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic resonance imaging (MRI) scans from 2148 MDD patients and 7957 healthy controls were analysed with harmonized protocols at 20 sites around the world...
June 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/26764529/bariatric-surgery-and-the-neuro-ophthalmologist
#18
REVIEW
Heather E Moss
BACKGROUND: As the prevalence of obesity increases, so, too, do the prevalences of weight-related diseases and surgical procedures to promote weight loss. It is important for neuro-ophthalmologists to be familiar with these procedures and possible downstream effects on afferent and efferent visual function. EVIDENCE ACQUISITION: Review of ophthalmology, neurology, general surgery, obesity, endocrinology, nutrition, psychiatry, and neurosurgery literature. RESULTS: Bariatric surgery is a safe and effective treatment for weight loss in obese individuals...
March 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26345354/-neuropsychiatric-manifestations-ushering-pernicious-anemia
#19
S Mrabet, F Ellouze, S Ellini, M F Mrad
Biermer disease or pernicious anemia is an autoimmune atrophic gastritis characterized by the lack of secretion of gastric intrinsic factor. This leads to an insufficient absorption of vitamin B12 in the ileum. Clinical manifestations are mainly hematologic. Neuropsychiatric manifestations are known but are less frequent especially early in the disease. Inaugural neuropsychiatric arrays are rare and various thus making diagnosis difficult. In this article, we report through two clinical cases different neuropsychiatric manifestations revealing pernicious anemia...
December 2015: L'Encéphale
https://www.readbyqxmd.com/read/26257482/personality-disorder-emotional-intelligence-and-locus-of-control-of-patients-with-alcohol-dependence
#20
Om Prakash, Neelu Sharma, Amool R Singh, K S Sengar, Suprakash Chaudhury, Jay Kumar Ranjan
AIM: To assess personality disorder (PD), emotional intelligence (EI), and locus of control of alcohol dependent (AD) patients and its comparison with normal controls. MATERIALS AND METHODS: Based on purposive sampling technique, 33 AD patients were selected from the De-Addiction Ward of Ranchi Institute of Neuro-Psychiatry and Allied Sciences (RINPAS) and 33 matched normal subjects were selected from Ranchi and nearby places. Both the groups were matched on various sociodemographic parameters, that is, age, gender, and socioeconomic level...
January 2015: Industrial Psychiatry Journal
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