Read by QxMD icon Read


Kana Ide, Masaya Koshizaka, Hirotake Tokuyama, Takahiko Tokuyama, Takahiro Ishikawa, Yoshiro Maezawa, Minoru Takemoto, Koutaro Yokote
BACKGROUND: Patients with type 2 diabetes are at high risk for cardiovascular disease. Although hydroxymethylglutaryl-CoA reductase inhibitors (statins) can reduce cardiovascular events, residual risk remains even after target low-density lipoprotein cholesterol (LDL-C) levels have been achieved. Lipoprotein particle size and fraction changes are thought to contribute to such risks. The purpose of this study was to evaluate the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), predominantly eicosapentaenoic acid and docosahexaenoic acid, on lipoprotein particle size, concentration, and glycemic control in Japanese patients with type 2 diabetes and hypertriglyceridemia...
March 15, 2018: Lipids in Health and Disease
Woojin Scott Kim, Eve Jary, Russell Pickford, Ying He, Rebekah M Ahmed, Olivier Piguet, John R Hodges, Glenda M Halliday
Behavioral variant frontotemporal dementia (bvFTD) is the most prevalent form of FTD syndromes. bvFTD is characterized clinically by changes in behavior and cognition and pathologically by focal brain atrophy and concomitant loss of lipids. bvFTD is further characterized by eating abnormalities that result in dyslipidemia. Although dyslipidemia is apparent in bvFTD, very little is known about global lipid changes in bvFTD and lipid dysregulation underlying bvFTD. Here, we undertook a comprehensive lipidomics analysis of blood plasma from patients with bvFTD, patients with Alzheimer's disease (AD) and controls, using liquid chromatography-tandem mass spectrometry, with the aim of understanding lipid dysregulation in bvFTD...
2018: Frontiers in Neurology
Jiaze Tan, Haitao Yang, Jingchuan Fan, Yulan Fan, Fei Xiao
OBJECTIVES: Neutral lipid storage disease with myopathy (NLSDM) is a rare metabolic myopathy occurring owing to mutations in the patatin like phospholipase domain containing 2 (PNPLA2) gene. Till date, less than 50 patients with PNPLA2 mutations have been reported. In this study, we describe the clinical, pathological, and genetic findings, and muscle magnetic resonance imaging (MRI) changes in four Chinese patients with NLSDM. PATIENTS AND METHODS: Peripheral blood smears were stained using Wright's stain...
March 5, 2018: Clinical Neurology and Neurosurgery
Divya Singh, Anita Ganger, Noopur Gupta, Murugesan Vanathi, Rajesh Khadgawat, Radhika Tandon
Here, we present, to the best of our knowledge, the first case of Werner syndrome with corneal blindness due to bilateral primary bullous keratopathy. Werner syndrome is a rare autosomal recessive disorder characterized by features of premature aging, insulin-dependent diabetes mellitus, osteoporosis, atherosclerosis, hypergonadotrophic hypogonadism, hypertriglyceridemia, scleroderma-like skin changes, and sarcomas. Among ocular manifestations, cataracts, cystoid macular edema, and retinal detachment have been reported...
March 9, 2018: Experimental and Clinical Transplantation
Beatriz Corredor-Andrés, María Teresa Muñoz-Calvo, Olga Calero, Cristina Aparicio, Jesús Argente, Miguel Calero
No abstract text is available yet for this article.
March 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Beatriz Corredor-Andrés, María Teresa Muñoz-Calvo, Olga Calero, Cristina Aparicio, Jesús Argente, Miguel Calero
No abstract text is available yet for this article.
March 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Sho Kitagawa, Koya Sawai
We declare that this manuscript is original, has not been published before and is not currently being considered for publication elsewhere. There are no conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. We obtained informed consent from the patient. The manuscript has been read and approved by all named authors. S. Kitagawa diagnosed the case and wrote the manuscript, and is the article guarantor. K...
March 9, 2018: American Journal of Medicine
Zhao Dong, Haozhe Shi, Mingming Zhao, Xin Zhang, Wei Huang, Yuhui Wang, Lemin Zheng, Xunde Xian, George Liu
OBJECTIVE: Lecithin cholesterol acyltransferase (LCAT) plays a pivotal role in HDL metabolism but its influence on atherosclerosis remains controversial for decades both in animal and clinical studies. Because lack of cholesteryl ester transfer protein (CETP) is a major difference between murine and humans in lipoprotein metabolism, we aimed to create a novel Syrian Golden hamster model deficient in LCAT activity, which expresses endogenous CETP, to explore its metabolic features and particularly the influence of LCAT on the development of atherosclerosis...
March 8, 2018: Metabolism: Clinical and Experimental
Ines Delgado, Lison Huet, Sandra Dexpert, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Agnès Aubert, Julie Sauvant, Bruno Aouizerate, Eric Magne, Lucile Capuron
BACKGROUND: Recent reports suggest that the risk of depressive symptoms in obesity is potentiated in subjects presenting a metabolically unhealthy phenotype. Inflammation is often considered a defining criteria of metabolic health. However, this factor may drive the association of metabolic health with depressive symptoms given its well-known role in the pathophysiology of depression. This study aimed at determining the relative contribution of inflammation and metabolic abnormalities to depressive symptoms in obesity...
March 6, 2018: Psychoneuroendocrinology
M Majerczyk, P Kocełak, P Choręza, H Arabzada, A J Owczarek, M Bożentowicz-Wikarek, A Brzozowska, A Szybalska, M Puzianowska-Kuźnicka, T Grodzicki, A Więcek, M Olszanecka-Glinianowicz, J Chudek
PURPOSE: Elevated plasma concentration of retinol binding protein 4 (RBP4) has recently emerged as a potential risk factor as a component of developing metabolic syndrome (MS). Therefore, this study aimed to analyse the relationship between components of MS and concentrations of plasma RBP4 in a population of subjects 65 years and older. METHODS: The study sample consisted of 3038 (1591 male) participants of the PolSenior study, aged 65 years and older. Serum lipid profile, concentrations of RBP4, glucose, insulin, C-reactive protein, IL-6, and activity of aminotransferases were measured...
March 9, 2018: Journal of Endocrinological Investigation
Mohammad Abu Zaid, Wambui G Gathirua-Mwangi, Chunkit Fung, Patrick O Monahan, Omar El-Charif, Annalynn M Williams, Darren R Feldman, Robert J Hamilton, David J Vaughn, Clair J Beard, Ryan Cook, Sandra K Althouse, Shirin Ardeshir-Rouhani-Fard, Paul C Dinh, Howard D Sesso, Lawrence H Einhorn, Sophie D Fossa, Lois B Travis
Background: Testicular cancer survivors (TCS) are at significantly increased risk for cardiovascular disease (CVD), with metabolic syndrome (MetS) an established risk factor. No study has addressed clinical and genetic MetS risk factors in North American TCS. Patients and Methods: TCS were aged <55 years at diagnosis and received first-line chemotherapy. Patients underwent physical examination, and had lipid panels, testosterone, and soluble cell adhesion molecule-1 (sICAM-1) evaluated. A single nucleotide polymorphism in rs523349 (5-α-reductase gene, SRD5A2 ), recently implicated in MetS risk, was genotyped...
March 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Adriana Moura Vieira, Poliana Guiomar de Almeida Brasiel, Maíra Schuchter Ferreira, Kacia Mateus, Mariana Sarto Figueiredo, Patrícia Cristina Lisboa, Egberto Gaspar de Moura, José Otavio do Amaral Corrêa, Fernando Cesar Ferraz Lopes, Paulo Henrique Fonseca da Silva, Céphora Maria Sabarense, Sheila Cristina Potente Luquetti Dutra, Aline Silva de Aguiar
PURPOSE: To evaluate the effects of maternal dietary soybean during lactation on the milk composition, body composition, lipid profile and glucose homeostasis of dams and offspring at weaning (21 days) and adulthood (150 days). METHODS: Lactating rats were divided into: casein control (C): casein diet; soy (S): soybean diet; soy oil control (SOC): casein diet, but with fat content similar to the S group. RESULTS: At 21 days, S mothers showed lower estradiol, total cholesterol (TC), low-density lipoprotein cholesterol (LDL) and triglycerides (TG) in serum; and lower TC and TG in milk...
March 8, 2018: Endocrine
Maria Chantal Ponziani, Ioannis Karamouzis, Chiara Mele, Luisa Chasseur, Marco Zavattaro, Marina Caputo, Maria Teresa Samà, Arianna Busti, Loredana Pagano, Luigi Castello, Paolo Marzullo, Gianluca Aimaretti, Flavia Prodam
OBJECTIVE: We evaluated the risk of altered glucose levels and new-onset diabetes (NOD) associated with statins according to glucose levels at baseline in a population treated for dyslipidemia on primary prevention for >5 years. DESIGN: The retrospective study included 308 subjects (265 on statins and 43 controls on diet) with a follow-up of 5-15 years. The cohort was classified according to glucose tolerance at both baseline and follow-up. RESULTS: The cumulative incidence of NOD was 13...
October 2017: Hormones: International Journal of Endocrinology and Metabolism
Gemma Sangüesa, José Carlos Montañés, Miguel Baena, Rosa María Sánchez, Núria Roglans, Marta Alegret, Juan Carlos Laguna
PURPOSE: Sugar-sweetened beverage intake is a risk factor for insulin resistance, dyslipidemia, fatty liver, and steatohepatitis (NASH). Sub-chronic supplementation of liquid fructose, but not glucose, in female rats increases liver and plasma triglycerides without inflammation. We hypothesized that chronic supplementation of fructose would cause NASH and liver insulin resistance. METHODS: We supplemented female Sprague-Dawley rats with water or either fructose or glucose 10% w/v solutions under isocaloric conditions for 7 months...
March 7, 2018: European Journal of Nutrition
Koshiro Sakai, Shinji Koba, Yuya Nakamura, Yuya Yokota, Fumiyoshi Tsunoda, Makoto Shoji, Yasuki Itoh, Yuji Hamazaki, Youichi Kobayashi
AIM: The study objective was to investigate whether small dense low-density lipoprotein cholesterol (sdLDL-C) is superior to low-density lipoprotein cholesterol (LDL-C) and other biomarkers to predict future cardiovascular events (CE) in secondary prevention. METHODS: sdLDL-C measured by a homogeneous assay, remnant lipoprotein cholesterol, LDL particle diameter and other biomarkers were compared in 345 men aged ≥65 years with stable coronary artery disease...
March 7, 2018: Geriatrics & Gerontology International
Ambika Amblee, Divyanshu Mohananey, Micheal Morkos, Sanjib Basu, Ayokunle Abegunde, Malini Ganesh, Neil Bhalerao, Amrutha Mary George, Milli Jain, Leon Fogelfeld
OBJECTIVE: To investigate the prevalence and predictors of hypertriglycerdemic acute pancreatitis (HTG-AP) in a multiethnic minority population. METHODS: A retrospective cross-sectional study from 2003 to 2013 of 1157 adults with serum triglyceride (TG) level ≥ 1000 mg/dL comparing baseline characteristics and risk factors between those with and without HTG-AP. RESULTS: Mean study population age was 49.2±11.5 years; 75.6% males; 31.6% African Americans, 38...
March 2, 2018: Endocrine Practice
J Dai, J Q Min, Y J Yang
Objective: To explore the current prevalence of dyslipidemia in adult population of 9 provinces of China and the epidemic characteristics of this disease. The potential influence of social economic development on dyslipidemia was also observed. Methods: Present research data are derived from the result of the investigation about survey on health and nutrition in China in 2011, in which multistage stratified cluster random sampling method was adopted to investigate the 24 345 individuals in 216 communities from 9 provinces in China and 10 242 blood samples were collected...
February 24, 2018: Zhonghua Xin Xue Guan Bing za Zhi
Michel P Hermans, Paul Valensi
PURPOSE OF REVIEW: The aim of this review is to describe in diabetic patients the determinants underlying atherogenic dyslipidemia, a complex dyslipidemia defined as the coexistence of fasting hypertriglyceridemia and low high-density lipoprotein cholesterol level. Atherogenic dyslipidemia is often comorbid with hyperglycemia in patients with the common form of type 2 diabetes mellitus (T2DM), namely that associated with obesity, insulin resistance, hyperinsulinemia and the metabolic syndrome phenotype...
April 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
Takahiro Ueda, Airo Tategaki, Kazuya Hamada, Hideyuki Kishida, Kazunori Hosoe, Hideyuki Morikawa, Kaku Nakagawa
The biological effects of heat-killed Pediococcus acidilactici R037 (R037) were evaluated when orally administered in mice and rats. Oral R037 administration at a daily dose of 10 and 100 mg/kg for 3 wk dose-dependently reduced fasting and non-fasting serum triglyceride concentrations in KK-Ay /TaJcl mice, a model of type II diabetes, obesity, hypercholesterolemia, and hypertriglyceridemia. Serum levels of free fatty acids in the 100 mg/kg group tended to decrease (not statistically significant), and total cholesterol levels remained unchanged...
2018: Journal of Nutritional Science and Vitaminology
Riley D Bowers, Sara M Valanejad, Ashley A Holombo
Acute pancreatitis has numerous etiologies, with the most common including gallstones, alcohol abuse, and medications such as angiotensin-converting enzyme (ACE) inhibitors, statins, and diuretics. Mirtazapine has been associated with increased serum cholesterol and serum triglyceride levels. However, few studies have reported dangerously elevated triglyceride levels resulting in acute pancreatitis. This report discusses a case of mirtazapine-induced pancreatitis in a 46-year-old African American female. The patient presented to the emergency department with pancreatitis, presumably alcohol-induced as with a prior admission, but she denied any recent alcohol use...
January 1, 2018: Journal of Pharmacy Practice
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"