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https://www.readbyqxmd.com/read/29665838/fungal-infections-in-adult-patients-on-extracorporeal-life-support
#1
Yiorgos Alexandros Cavayas, Hakeem Yusuff, Richard Porter
BACKGROUND: Patients on extracorporeal membrane oxygenation (ECMO) are often among the most severely ill in the intensive care unit. They are often receiving broad-spectrum antibiotics; they have multiple entry points for pathogens; and their immune system is impaired by blood circuit interaction. These factors are thought to predispose them to fungal infections. We thus aimed to evaluate the prevalence, risk factors, and prognosis of fungal infections in adults on ECMO. METHODS: We conducted a retrospective cohort study using the Extracorporeal Life Support Organization registry, which compiles data on ECMO use from hundreds of international centers...
April 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29665345/evaluation-of-ifn-%C3%AE-enzyme-linked-immunospot-assay-elispot-as-a-first-line-test-in-the-diagnosis-of-non-immediate-hypersensitivity-to-amoxicillin-and-penicillin
#2
Lenka Sedláčková, Miroslav Průcha, Ingrid Poláková, Blanka Míková
The current diagnostic algorithm for beta-lactam allergy is based on skin and provocation tests, both of which carry a certain risk of inducing hypersensitivity reactions. Thus, non-invasive in vitro tests reliable enough to replace skin and provocation tests at least in a portion of patients are desirable. We aimed to verify the utility of IFN-γ ELISPOT as a first-line test in patients with suspected non-immediate hypersensitivity reaction to amoxicillin (AMX) and penicillin (PNC). The prospective observational study included 24 patients with recent, suspected non-immediate hypersensitivity reaction to AMX or PNC and 6 recently-exposed healthy subjects...
2018: Prague Medical Report
https://www.readbyqxmd.com/read/29663934/fructose-enhanced-antimicrobial-activity-of-silver-nanoparticle-embedded-polymersome-nanocarriers
#3
Ilia Gelfat, Benjamin M Geilich, Thomas J Webster
In recent years, an increasing body of research has indicated that the antimicrobial activity of certain antibiotic drugs can be enhanced by the addition of specific metabolites. This study aimed to incorporate these findings into polymersomes (novel polymer-based nanoscale drug delivery vehicles) which can be loaded with various therapeutic molecules and nanoparticles. Polymersome technology has shown promising results in treating antibiotic-resistant infections by co-encapsulating the antibiotic methicillin with silver nanoparticles...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663554/implant-associated-bacterial-biofilm-and-quorum-sensing-in-periprosthetic-joint-infections
#4
Jake A Mooney, Eric M Pridgen, Robert Manasherob, Gina Suh, Helen E Blackwell, Annelise E Barron, Paul L Bollyky, Stuart B Goodman, Derek F Amanatullah
Periprosthetic joint infection (PJI) continues to be a common complication after total knee arthroplasty and total hip arthroplasty leading to severe morbidity and mortality. With an aging population and increasing prevalence of total joint replacement procedures, the burden of PJI will be felt not only by individual patients, but in increased healthcare costs. Current treatment of PJI is inadequate resulting in incredibly high failure rates. This is believed to be largely mediated by the presence of bacterial biofilms...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29660396/analysis-of-clinical-management-of-infected-breast-implants-and-of-factors-associated-to-successful-breast-pocket-salvage-in-infections-occurring-after-breast-reconstruction
#5
Simonetta Franchelli, Marianna Pesce, Ilaria Baldelli, Anna Marchese, Pierluigi Santi, Andrea De Maria
OBJECTIVES: Considerable efforts have been devoted so far to improve salvage procedures of infected breast implants in absence of defined guidelines or validated clinical protocols. Within a cohort of prospectively recruited patients who underwent breast reconstruction, we performed a retrospective review of proven implant infections in order to describe factors contributing to management success. METHODS: We collected data in 1293 consecutive patients who underwent two stage (expander+ prosthesis) breast reconstruction with at least 12 months of follow-up...
April 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29659363/-late-diagnosis-of-whim-sydrome
#6
María V Paolini, Silvia Danielian, Emma Prieto, María Fernanda Tami, Matías M Oleastro, Diego S Fernández Romero
WHIM syndrome is a primary autosomal dominant immuno deficiency due to CXCR4 mutations characterized by mucocutaneous warts, hypogammaglobulinemia, recurrent bacterial infections and myelokathesis. Treatment consists in prophylactic antibiotics, immunoglobulin replacement and granulocyte or granulocyte/monocyte colony stimulating factors. We present the case of a 21 year old woman who showed leukopenia at 10 months of age and one year later multiple infections with hypogammaglobulinemia requiring intravenous immunoglobulin...
2018: Medicina
https://www.readbyqxmd.com/read/29656714/epidemiology-of-sepsis-in-intensive-care-units-in-turkey-a-multicenter-point-prevalence-study
#7
Nur Baykara, Halis Akalın, Mustafa Kemal Arslantaş, Volkan Hancı, Çiğdem Çağlayan, Ferda Kahveci, Kubilay Demirağ, Canan Baydemir, Necmettin Ünal
BACKGROUND: The prevalence and mortality of sepsis are largely unknown in Turkey, a country with high antibiotic resistance. A national, multicenter, point-prevalence study was conducted to determine the prevalence, causative microorganisms, and outcome of sepsis in intensive care units (ICUs) in Turkey. METHODS: A total of 132 ICUs from 94 hospitals participated. All patients (aged > 18 years) present at the participating ICUs or admitted for any duration within a 24-h period (08:00 on January 27, 2016 to 08:00 on January 28, 2016) were included...
April 16, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29655419/a-two-dimensional-metal-organic-framework-nanosheets-based-fluorescence-resonance-energy-transfer-aptasensor-with-circular-strand-replacement-dna-polymerization-target-triggered-amplification-strategy-for-homogenous-detection-of-antibiotics
#8
Qian Yang, Lingying Zhou, Yong-Xiang Wu, Kai Zhang, Yuting Cao, You Zhou, Dazhen Wu, Futao Hu, Ning Gan
In the study, a novel two dimensional metal-organic framework (Cu-TCPP nanosheets) based fluorescence resonance energy transfer (FRET) aptasensing platform was developed for detecting antibiotics. Cu-TCPP nanosheets were employed for quenching the background fluorescence and circular strand-replacement DNA polymerization (CSRP) for signal amplification. To fulfill the purpose, we designed an aptamer hairpin probe (HP) whose stem can be opened while specifically binding to target. Then the opened HP would bind with the primer...
August 22, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29652913/ventilator-associated-pneumonia-in-patients-assisted-by-veno-arterial-extracorporeal-membrane-oxygenation-support-epidemiology-and-risk-factors-of-treatment-failure
#9
Adrien Bouglé, Camille Bombled, Dimitri Margetis, Guillaume Lebreton, Charles Vidal, Marine Coroir, David Hajage, Julien Amour
INTRODUCTION: Ventilator-associated pneumonia (VAP) is frequent in Intensive Care Unit (ICU) patients. In the specific case of patients treated with Veno-Arterial Extracorporeal Membrane Oxygenation Support (VA-ECMO), VAP treatment failures (VAP-TF) have been incompletely investigated. METHODS: To investigate the risk factors of treatment failure (VAP-TF) in a large cohort of ICU patients treated with VA-ECMO, we conducted a retrospective study in a Surgical ICU about patients assisted with VA-ECMO between January 1, 2013, and December 31, 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29650991/a-new-way-of-producing-pediocin-in-pediococcus-acidilactici-through-intracellular-stimulation-by-internalized-inulin-nanoparticles
#10
Whee-Soo Kim, Jun-Yeong Lee, Bijay Singh, Sushila Maharjan, Liang Hong, Sang-Mok Lee, Lian-Hua Cui, Ki-June Lee, GiRak Kim, Cheol-Heui Yun, Sang-Kee Kang, Yun-Jaie Choi, Chong-Su Cho
One of the most challenging aspects of probiotics as a replacement for antibiotics is to enhance their antimicrobial activity against pathogens. Given that prebiotics stimulate the growth and/or activity of probiotics, we developed phthalyl inulin nanoparticles (PINs) as prebiotics and observed their effects on the cellular and antimicrobial activities of Pediococcus acidilactici (PA). First, we assessed the internalization of PINs into PA. The internalization of PINs was largely regulated by glucose transporters in PA, and the process was energy-dependent...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650059/labyrinthitis-ossificans-in-a-cynomolgus-macaque-macaca-fascicularis
#11
Gayathriy Balamayooran, Hannah M Atkins, Christopher T Whitlow, Samuel T Aycock, Michael A Nader, J Mark Cline, David L Caudell
Labyrinthitis is inflammation of the membranous and bony labyrinth of the inner ear. Typical portals of entry includehematogenous spread from the cochlear vasculature, passage of otitis media pathogens through the round window, and mostcommonly, meningogenic spread from the subarachnoid space. The sequela of chronic inner ear inflammation is labyrinthitisossificans, in which inner ear structures are replaced by fibrous and osseous tissues. Labyrinthitis in humans has been reportedconcurrently with infection due to various viruses (for example, varicella-zoster, measles, mumps) and bacteria (for example,Treponema pallidum, Streptococcus pneumoniae) and may be associated with vertebrobasilar ischemia and meningitis...
April 12, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29649778/in-silico-design-of-small-peptides-antagonist-against-leptin-receptor-for-the-treatment-of-obesity-and-its-associated-immune-mediated-diseases
#12
Manne Munikumar, Vagolu Siva Krishna, Varikasuvu Seshadri Reddy, Bolla Rajeswari, Dharmarajan Sriram, Mendu Vishnuvardhana Rao
Excess adiposity in obese inhibits negatively impacts immune function and host defence. Obesity is characterized by a state of low-grade, chronic inflammation in addition to disturbed levels of circulating nutrients and metabolic hormones. The impact of metabolic abnormalities on obesity-related co-morbidities has undergone intense scrutiny over the past decades. Thus, treatment of obesity and its associated immune-mediated diseases is challenging due to impaired function of leptin system. These disorders are managed through antibiotics and by cytokines replacement...
April 4, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29644292/serious-phlegmonous-lesion-of-the-hand-following-an-injury-by-vegetal-thorn-never-forget-pasteurella-multocida
#13
A Maleb, J Elmalki, O Bouayadi, Y Ben Lahlou, M Frikh, N Abdeljaouad, A Lemnouer, H Yacoubi, M Elouennass
Pasteurella multocida can cause serious infections after dog or cat bite. We report here a rare case of hand infection caused by P. multocida consecutive to an injury by a thorn of the prickly pear. It caused an amputation of the distal phalanx of the thumb in a trisomic patient. It is about a 27-year-old man who was admitted to the hospital with swelling and intense pain of the left hand. He reported a sting by a thorn of prickly pear 15 days before. The patient was admitted to proceed with operative irrigation and debridement...
February 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29630121/the-additional-role-of-18f-fdg-pet-ct-in-prosthetic-valve-endocarditis
#14
S Nuvoli, V Fiore, S Babudieri, S Galassi, P Bagella, P Solinas, A Spanu, G Madeddu
OBJECTIVE: The purpose of the present review is an update on the diagnosis of prosthetic valve endocarditis (PVE), evaluating the additional value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) to the standard modified DUKE criteria on which for a long time is based the diagnostic strategy of the disease. MATERIALS AND METHODS: We did a comprehensive research on the studies reported in the literature and regarding the employment of 18F-FDG PET/CT in the early diagnosis of PVE in patients with suspected disease...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29629769/developing-equipotent-teixobactin-analogues-against-drug-resistant-bacteria-and-discovering-a-hydrophobic-interaction-between-lipid-ii-and-teixobactin
#15
Yu Zong, Xiuyun Sun, Hongying Gao, Kirsten J Meyer, Kim Lewis, Yu Rao
Teixobactin, targeting lipid II, represents a new class of antibiotics with novel structures and has excellent activity against Gram-positive pathogens. We developed a new convergent method to synthesize a series of teixobactin analogues and explored structure-activity relationships. We obtained equipotent and simplified teixobactin analogues, replacing the l- allo-enduracididine with lysine, substituting oxygen to nitrogen on threonine, and adding a phenyl group on the d-phenylalanine. On the basis of the antibacterial activities that resulted from corresponding modifications of the d-phenylalanine, we propose a hydrophobic interaction between lipid II and the N-terminal of teixobactin analogues, which we map out with our analogue 35...
April 13, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29624209/withdrawn-grommets-ventilation-tubes-for-recurrent-acute-otitis-media-in-children
#16
REVIEW
Loretta Lau, Paul Mick, Desmond A Nunez
BACKGROUND: This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2008 and previously updated in 2011.Acute suppurative otitis media is one of the most common infectious diseases in childhood. Recurrent acute otitis media is defined for the purposes of this review as either three or more acute infections of the middle ear cleft in a six-month period, or at least four episodes in a year. Strategies for managing the condition include the assessment and modification of risk factors where possible, repeated courses of antibiotics for each new infection, antibiotic prophylaxis and the insertion of ventilation tubes (grommets)...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29619607/pharmacokinetic-pharmacodynamic-considerations-of-beta-lactam-antibiotics-in-adult-critically-ill-patients
#17
REVIEW
Anne M Masich, Mojdeh S Heavner, Jeffrey P Gonzales, Kimberly C Claeys
PURPOSE OF REVIEW: Beta-lactam antibiotics are commonly prescribed in critically ill patients for a variety of infectious conditions. Our understanding of how critical illness alters beta-lactam pharmacokinetics/pharmacodynamics (PK/PD) is rapidly evolving. RECENT FINDINGS: There is a growing body of literature in adult patients demonstrating that physiological alterations occurring in critically ill patients may limit our ability to optimally dose beta-lactam antibiotics to reach these PK/PD targets...
April 4, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29614489/hyperbaric-oxygen-therapy-as-adjuvant-treatment-for-hardware-related-infections-in-neuromodulation
#18
Jiri Bartek, Simon Skyrman, Michael Nekludov, Tiit Mathiesen, Folke Lind, Gaston Schechtmann
BACKGROUND: In neuromodulation therapies, hardware-related infections are a major challenge often leading to hardware removal. OBJECTIVE: To investigate the role of adjuvant hyperbaric oxygen therapy (HBOT) in hardware-related infections. METHODS: Fourteen hardware-related infection events in 12 consecutive patients between 2002 and 2015 were treated with antibiotics and adjuvant HBOT at the Karolinska University Hospital (Stockholm, Sweden)...
April 3, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29600207/treating-a-recalcitrant-non-union-of-the-radius-using-autogenous-bone-equine-bone-paste-equine-demineralized-bone-matrix-platelet-rich-plasma-and-bone-marrow-aspirate-a-case-report
#19
Ferdinando Da Rin De Lorenzo
Introduction: Non-unions at forearms are usually challenging and difficult to treat. If additionally, an infection is present, reconstructive surgery should be planned only after full debridement, antibiotic treatment, and confirmation, based on clinical observation and laboratory tests that the infection has subsided. Bone grafting may be required for reconstruction. The use of autogenous bone calls for a second surgical site with an increased risk of morbidity. Using bone substitutes may reduce the need for autogenous bone...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29600105/fan-shaped-ground-glass-opacity-ggo-as-a-premonitory-sign-of-pulmonary-infarction-a-case-report
#20
Tsutomu Shinohara, Keishi Naruse, Norihiko Hamada, Takashi Yamasaki, Nobuo Hatakeyama, Fumitaka Ogushi
Radiological findings of pulmonary infarction have been well characterized mainly in established infarction. However, the early course CT appearance of patients who develop pulmonary infarction has not yet been fully elucidated. A 50-year-old female with a history of postmenopausal hormone replacement therapy (HRT) presented with dry cough and high-resolution computed tomography (HRCT) findings of fan-shaped segmental ground-glass opacity (GGO) in the right lower lobe. As the parenchymal density in the GGO gradually enlarged over a period of 4 weeks in spite of antibiotic treatment, the patient was referred to our hospital on clinical suspicion of bronchioloalveolar cell carcinoma...
January 2018: Journal of Thoracic Disease
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