keyword
MENU ▼
Read by QxMD icon Read
search

antibiotic replacement

keyword
https://www.readbyqxmd.com/read/29044341/the-use-of-antimicrobials-in-septic-patients-with-acute-kidney-injury
#1
Fernanda Moreira de Freitas, Welder Zamoner, Durval Sampaio de Souza Garms, Mariele Gobo de Oliveira, André Luis Balbi, Daniela Ponce
Sepsis is the most common cause of death in critically ill patients and it may be associated with multiorgan failure, including acute kidney injury (AKI). This situation can require acute renal support and increase mortality. Therefore, it is essential to administrate antimicrobials in dosis to achieve adequate serum levels, preventing overdosis and drug toxicity or underdosing and risk for resistance to antibiotics and higher mortality. To date, there aren't validated guidelines on antibiotic dosis adjustment in septic patients with AKI and the recommendations are extrapolated from studies conducted in non-critical patients with chronic kidney disease in end stage receiving chronic renal replacement therapy...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29043145/anca-associated-pauci-immune-glomerulonephritis-in-a-patient-with-bacterial-endocarditis-a-challenging-clinical-dilemma
#2
Andrea Cervi, Dylan Kelly, Iakovina Alexopoulou, Nader Khalidi
PURPOSE: We report the case of a 59-year-old man with chronic hepatitis B and C infection presenting with acute kidney injury and enterococcus faecalis-infective endocarditis (IE). An elevated proteinase-3 (PR3)-ANCA and pauci-immune glomerulonephritis (GN) on renal biopsy were discovered, corresponding to ANCA-mediated GN. We conducted a literature review to assess the role of ANCA in IE and treatment implications. METHODS: On systematic review of the literature, we found five previous cases whereby IE caused by streptococcus and bartonella species were related to ANCA vasculitis-associated GN...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29039211/synergistic-effects-of-heat-and-antibiotics-on-pseudomonas-aeruginosa-biofilms
#3
Erica B Ricker, Eric Nuxoll
Upon formation of a biofilm, bacteria undergo several changes that prevent eradication with antimicrobials alone. Due to this resistance, the standard of care for infected medical implants is explantation of the infected implant and surrounding tissue, followed by eventual reimplantation of a replacement device. Recent studies have demonstrated the efficacy of heat shock for biofilm eradication. To minimize the heat required for in situ biofilm eradication, this study investigated the hypothesis that antibiotics, while ineffective by themselves, may substantially increase heat shock efficacy...
October 17, 2017: Biofouling
https://www.readbyqxmd.com/read/29038126/transcervical-inoculation-with-chlamydia-trachomatis-induces-infertility-in-hla-dr4-transgenic-and-wild-type-mice
#4
Sukumar Pal, Delia F Tifrea, Guangming Zhong, Luis M de la Maza
Chlamydia trachomatis (Ct) is the leading cause of infection-induced infertility in women. Attempts to control this epidemic with screening programs and antibiotic therapy have failed. Currently, a vaccine to prevent Ct infections is not available. In order to develop an animal model for evaluating vaccine antigens that can be applied to humans, we used Ct serovar D (strain UW-3/Cx) (Ct-D) to induce infertility in mice whose major histocompatibility complex class II antigen was replaced with the human leukocyte antigen (HLA)-DR4...
October 16, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29037910/antimicrobial-photodynamic-therapy-for-infectious-stomatitis-in-snakes-clinical-views-and-microbiological-findings
#5
Kathleen Fernandes Grego, Marcelo Pires Nogueira de Carvalho, Marcos Paulo Vieira Cunha, Terezinha Knöbl, Fabio Celidonio Pogliani, José Luiz Catão-Dias, Sávio Stefanini Sant'Anna, Martha Simões Ribeiro, Fábio Parra Sellera
BACKGROUND: Antimicrobial photodynamic therapy (APDT) has been broadly investigated as an alternative to treat localized infections, without leading to the selection of resistant microorganisms. Infectious stomatitis is a multifactorial disease frequently reported in captive snakes characterized by infection of the oral mucosa and surrounding tissues. In this study, we investigated methylene blue (MB)-mediated APDT to treat infectious stomatitis in snakes and verified the resistance phenotype and genotype before and after APDT...
October 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29036953/-a-clinical-analysis-of-six-patients-with-brucella-endocarditis-and-literature-review
#6
L Luo, B T Zhou, H L Wang, H T Dou, T S Li
Objective: To analyze the epidemiology and clinical characteristics of patients with Brucella endocarditis in order to improve the understanding and treatment of Brucella endocarditis. Methods: The clinical data including demographic characteristics, clinical features, laboratory data, echocardiography, treatment and clinical outcome of 6 patients with Brucella endocarditis were collected and analyzed. Results: In our database consisting of 211 brucellosis patients with positive blood culture, 6 patients (2...
October 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29035420/modeling-the-secondary-structures-of-the-peptaibols-antiamoebin-i-and-zervamicin-ii-modified-with-d-amino-acids-and-proline-analogues
#7
Tarsila G Castro, Nuno M Micaêlo, Manuel Melle-Franco
Antiamoebin I (AAM-I) and zervamicin II (Zrv-IIB) are peptaibols that exert antibiotic activity through the insertion/disruption of cell membranes. In this study, we investigated how the folding of these peptaibols are affected when some of their native residues are replaced with proline analogues and asymmetrical D-α,α-dialkyl glycines (two classes of noncanonical amino acids). Systematic substitutions of native Aib, Pro, Hyp, and Iva residues were performed to elucidate the folding properties of the modified peptaibols incorporating noncanonical residues...
October 16, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29034025/replacement-of-the-thoracoabdominal-aorta-after-endovascular-abdominal-aneurysm-repair-for-ruptured-infected-aneurysm-a-case-report
#8
Nobuo Kondo, Kentaro Tamura, Taichi Sakaguchi, Genta Chikazawa, Hidenori Yoshitaka
A 73-year-old man underwent emergency endovascular abdominal aneurysm repair (EVAR) for a ruptured infected abdominal aortic aneurysm. Two years after EVAR, he was admitted with a spiking fever and left lower back pain. Computed tomography scan revealed not only recurrent graft infection with psoas abscess but also infection around the orifice of the superior mesenteric artery. Because conservative medical therapy with antibiotics could not control the infection, we performed complete removal of the infected stent graft, debridement of psoas abscess, and in situ replacement of the thoracoabdominal aorta using rifampicin-soaked prosthetic grafts, followed by the omental flap...
March 24, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29026652/pre-vaccine-serotype-composition-within-a-lineage-signposts-its-serotype-replacement-a-carriage-study-over-7-years-following-pneumococcal-conjugate-vaccine-use-in-the-uk
#9
Rebecca A Gladstone, Vanessa Devine, Jessica Jones, David Cleary, Johanna M Jefferies, Stephen D Bentley, Saul N Faust, Stuart C Clarke
Serotype replacement has been reported in carriage and disease after pneumococcal conjugate vaccine (PCV) introductions in the UK and globally. We previously described concurrent expansion and decline of sequence types associated with serotype replacement over 5 years following PCV introductions in the UK. Here we use whole-genome sequencing to fully characterise the population structure of pneumococcal isolates collected over seven winters encompassing PCV7 and PCV13 introductions in the UK, investigating the importance of lineages in serotype replacement...
June 30, 2017: Microbial Genomics
https://www.readbyqxmd.com/read/29023057/dynamic-of-bacterial-diversity-in-ileum-digesta-under-water-supplements-of-antibiotics-and-probiotics
#10
Raed MahmoudAl-Atiyat
BACKGROUND AND OBJECTIVE: Intestinal bacteria plays an important role in the physiological and immunological status of birds. The present study investigated the diversity of intestinal bacterial of broilers that were fed corn-soy diet and supplements of antibiotics and probiotics. MATERIALS AND METHODS: The supplemented treatments were water, water with antibiotics, water with probiotic and water with antibiotics and probiotic. Eight randomly sampled broilers were slaughtered and their ileum digesta taken...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022997/phytochemical-analysis-identification-and-quantification-of-antibacterial-active-compounds-in-betel-leaves-piper-betle-methanolic-extract
#11
A Syahidah, C R Saad, M D Hassan, Y Rukayadi, M H Norazian, M S Kamarudin
BACKGROUND AND OBJECTIVE: The problems of bacterial diseases in aquaculture are primarily controlled by antibiotics. Medicinal plants and herbs which are seemed to be candidates of replacements for conventional antibiotics have therefore gained increasing interest. Current study was performed to investigate the presence of phytochemical constituents, antibacterial activities and composition of antibacterial active compounds in methanolic extract of local herb, Piper betle . METHODOLOGY: Qualitative phytochemical analysis was firstly carried out to determine the possible active compounds in P...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29021946/predictors-of-pneumococcal-carriage-and-the-effect-of-the-13-valent-pneumococcal-conjugate-vaccination-in-the-western-australian-aboriginal-population
#12
Deirdre A Collins, Anke Hoskins, Thomas Snelling, Kalpani Senasinghe, Jacinta Bowman, Natalie A Stemberger, Amanda J Leach, Deborah Lehmann
BACKGROUND: The 7-valent pneumococcal conjugate vaccine (PCV7) was introduced to prevent invasive pneumococcal disease (IPD) in Western Australian (WA) Aboriginal people in 2001. PCV13 replaced PCV7 in July 2011, covering six additional pneumococcal serotypes; however, IPD rates remained high in Aboriginal people in WA. Upper respiratory tract pneumococcal carriage can precede IPD, and PCVs alter serotype distribution. METHODS: To assess the impact of PCV13 introduction, identify emerging serotypes, and assess risk factors for carriage, nasopharyngeal swabs and information on demographic characteristics, health, medication and living conditions from Aboriginal children and adults across WA from August 2008 to November 2014 were collected...
2017: Pneumonia
https://www.readbyqxmd.com/read/29018429/d-ribose-interferes-with-quorum-sensing-to-inhibit-biofilm-formation-of-lactobacillus-paraplantarum-l-zs9
#13
Lei Liu, Ruiyun Wu, Jinlan Zhang, Nan Shang, Pinglan Li
Biofilms help bacteria survive under adverse conditions, and the quorum sensing (QS) system plays an important role in regulating their activities. Quorum sensing inhibitors (QSIs) have great potential to inhibit pathogenic biofilm formation and are considered possible replacements for antibiotics; however, further investigation is required to understand the mechanisms of action of QSIs and to avoid inhibitory effects on beneficial bacteria. Lactobacillus paraplantarum L-ZS9, isolated from fermented sausage, is a bacteriocin-producing bacteria that shows potential to be a probiotic starter...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28990821/enrichment-broth-for-the-detection-of-campylobacter-jejuni-and-campylobacter-coli-in-fresh-produce-and-poultry
#14
Youmi Jo, Hye-Min Oh, Yohan Yoon, Sun-Young Lee, Ji-Hyoung Ha, Won-Il Kim, Hwang-Yong Kim, Sanghyun Han, Se-Ri Kim
Although campylobacteriosis caused by Campylobacter jejuni and Campylobacter coli has been increasingly reported worldwide owing to the consumption of contaminated poultry and fresh produce, the current detection protocols are not selective enough to inhibit unspecific microbes other than these pathogens. Five antibiotics were separately added to Bolton broth, and the survival rates of 18 Campylobacter spp. and 79 non-Campylobacter spp. were evaluated. The survival rate of the non-Campylobacter spp. was the lowest in Bolton broth with rifampin (6...
October 9, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28990652/bronchiectasis-and-deteriorating-lung-function-in-agammaglobulinemia-despite-immunoglobulin-replacement-therapy
#15
A Stubbs, C Bangs, B Shillitoe, J D Edgar, S O Burns, M Thomas, H Alachkar, M Buckland, E McDermott, G Arumugakani, M S Jolles, R Herriot, P D Arkwright
Immunoglobulin replacement therapy enhances survival and reduces infection risk in patients with agammaglobulinemia. We hypothesized that despite regular immunoglobulin therapy some patients will experience ongoing respiratory infections and develop progressive bronchiectasis with deteriorating lung function. 139 (70%) of 199 patients aged 1 to 80 years from nine cities in the UK with agammaglobulinemia currently listed on the UKPID registry were recruited to this retrospective case study and their clinical and laboratory features analyzed...
October 9, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28989972/a-new-take-on-an-old-remedy-generating-antibodies-against-multidrug-resistant-gram-negative-bacteria-in-a-postantibiotic-world
#16
Michael P Motley, Bettina C Fries
With the problem of multidrug-resistant Gram-negative pathogens becoming increasingly dire, new strategies are needed to protect and treat infected patients. Though abandoned in the past, monoclonal antibody therapy against Gram-negative bacteria remains a potential solution and has potential advantages over the broad-spectrum antibiotics they were once replaced by. This Perspective reviews the prospect of utilizing monoclonal antibody therapy against these pathogens, as well as the challenges of doing so and the current therapy targets under investigation...
September 2017: MSphere
https://www.readbyqxmd.com/read/28983294/lipoteichoic-acid-of-probiotic-lactobacillus-plantarum-attenuates-poly-i-c-induced-il-8-production-in-porcine-intestinal-epithelial-cells
#17
Kyoung Whun Kim, Seok-Seong Kang, Sun-Je Woo, Ok-Jin Park, Ki Bum Ahn, Ki-Duk Song, Hak-Kyo Lee, Cheol-Heui Yun, Seung Hyun Han
Probiotics in livestock feed supplements are considered a replacement for antibiotics that enhance gastrointestinal immunity. Although bacterial cell wall components have been proposed to be associated with probiotic function, little evidence demonstrates that they are responsible for probiotic functions in livestock. The present study demonstrated that lipoteichoic acid (LTA) of Lactobacillus plantarum (Lp.LTA) confers anti-inflammatory responses in porcine intestinal epithelial cell line, IPEC-J2. A synthetic analog of viral double-stranded RNA, poly I:C, dose-dependently induced IL-8 production at the mRNA and protein levels in IPEC-J2 cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28983214/factors-associated-with-choice-and-success-of-one-versus-two-stage-revision-arthroplasty-for-infected-hip-and-knee-prostheses
#18
Lucas Castellani, Nick Daneman, Samira Mubareka, Richard Jenkinson
BACKGROUND: Prosthetic joint infections (PJI) of hip and knee arthroplasties are becoming increasingly common with an aging population and an increasing demand for these procedures. Despite attempts at standardization, medical and surgical approaches vary widely among practitioners. QUESTIONS/PURPOSES: We first sought to determine if there were specific factors associated with choice of one- versus two-stage revision. Then we investigated whether the type of revision approach influenced clinical treatment success...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28982312/electrochemical-mip-sensors-for-drugs
#19
Aysu Yarman, Sevinc Kurbanoglu, Katharina J Jetzschmann, Sibel A Ozkan, Ulla Wollenberger, Frieder Scheller
In order to replace bio-macromolecules by stable synthetic materials in separation techniques and bioanalysis biomimetic receptors and catalysts have been developed: Functional monomers are polymerized together with the target analyte and after template removal cavities are formed in the "molecularly imprinted polymer" (MIP) which resemble the active sites of antibodies and enzymes. Staring almost 80 years ago, around 1,100 papers on MIPs were published in 2016. Electropolymerization allows to deposit MIPs directly on voltammetric electrodes or chips for quartz crystal microbalance (QCM) and surface plasmon resonance (SPR)...
October 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28981793/testing-the-mutant-selection-window-hypothesis-with-staphylococcus-aureus-exposed-to-linezolid-in-an-in-vitro-dynamic-model
#20
Alexander A Firsov, Kamilla N Alieva, Elena N Strukova, Maria V Golikova, Yury A Portnoy, Svetlana A Dovzhenko, Mikhail B Kobrin, Andrey V Romanov, Mikhail V Edelstein, Stephen H Zinner
Objectives: To test the mutant selection window (MSW) hypothesis applied to linezolid-exposed Staphylococcus aureus and to delineate the concentration-resistance relationship, a mixed inoculum of linezolid-susceptible S. aureus cells and linezolid-resistant mutants (RMs) was exposed to linezolid multiple dosing. Methods: Three S. aureus strains (MIC of linezolid 2 mg/L), S. aureus 479, S. aureus 688 and S. aureus ATCC 700699, and their RMs (MIC 8 mg/L) selected by passaging on antibiotic-containing media were used in the study...
July 31, 2017: Journal of Antimicrobial Chemotherapy
keyword
keyword
73658
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"