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https://www.readbyqxmd.com/read/28526588/adam10-and-%C3%AE-secretase-regulate-sensory-regeneration-in-the-avian-vestibular-organs
#1
Mark E Warchol, Jennifer Stone, Matthew Barton, Jeffrey Ku, Rose Veile, Nicolas Daudet, Michael Lovett
The loss of sensory hair cells from the inner ear is a leading cause of hearing and balance disorders. The mammalian ear has a very limited ability to replace lost hair cells, but the inner ears of non-mammalian vertebrates can spontaneously regenerate hair cells after injury. Prior studies have shown that replacement hair cells are derived from epithelial supporting cells and that the differentiation of new hair cells is regulated by the Notch signaling pathway. The present study examined molecular influences on regeneration in the avian utricle, which has a particularly robust regenerative ability...
May 16, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28526570/role-of-medicinal-plants-on-growth-performance-and-immune-status-in-fish
#2
REVIEW
Elham Awad, Amani Awaad
Disease outbreaks increase proportionally with increases in intensive aquaculture. Natural products including medicinal plants have been known from thousands of years for treating some human diseases. It is well known that many active compounds are responsible for potential bio-activities. For that reason, there has been considerable interest in the use of medicinal plants in aquaculture with a view to providing safe and eco-friendly compounds for replacing antibiotics and chemical compounds as well as to enhance immune status and control fish diseases...
May 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28526569/total-joint-replacement-for-neglected-posterior-knee-dislocation-following-septic-arthritis-after-arthroscopy
#3
Yusuf Öztürkmen, Yunus Emre Akman, Ethem Ayhan Ünkar, Erhan Şükür
This report presents the first case of a knee dislocation following septic arthritis after arthroscopy. A 65-year-old woman had an arthroscopy with irrigation and debridement (I&D) of the joint and microfracture for the chondral lesions. She had complaints of postarthroscopic infection but non-steroidal anti-inflammatory medication and local ice compression was recommended. She revisited her physician twice and at the last visit she had a large purulent effusion in her knee. The gram stain of the joint fluid aspirate demonstrated gram-positive cocci and the cultures grew methicilline-sensitive Staphylococcus aureus...
May 16, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28524741/a-surgical-case-of-mycotic-aneurysm-with-staphylococcus-lugdunensis-endocarditis
#4
Kosuke Mukaihara, Kazuhisa Matsumoto, Jun Kadono, Yutaka Imoto
A 74-year-old man with a history of mitral valve repair was referred to our hospital with fever and diagnosed with mitral valve endocarditis involving occlusion of the superior mesenteric artery. Bacterial cultures showed Staphylococcus lugdunensis. Despite antibiotic therapy, orthopnea ensued due to valve destruction. Emergency mitral valve replacement was performed. Computed tomography on postoperative day 10 revealed a rapidly expanding mycotic aneurysm of the superior mesenteric artery. Aneurysmectomy was undertaken...
May 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28511681/chromosome-engineering-of-escherichia-coli-for-constitutive-production-of-salvianic-acid-a
#5
Liang Zhou, Qi Ding, Guo-Zhen Jiang, Zhen-Ning Liu, Hai-Yan Wang, Guang-Rong Zhao
BACKGROUND: Salvianic acid A (SAA), a valuable natural product from herbal plant Salvia miltiorrhiza, exhibits excellent antioxidant activities on food industries and efficacious therapeutic potential on cardiovascular diseases. Recently, production of SAA in engineered Escherichia coli was established via the artificial biosynthetic pathway of SAA on the multiple plasmids in our previous work. However, the plasmid-mediated system required to supplement expensive inducers and antibiotics during the fermentation process, restricting scale-up production of SAA...
May 16, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28511343/restoration-of-mir-143-expression-could-inhibit-migration-and-growth-of-mda-mb-468-cells-through-down-regulating-the-expression-of-invasion-related-factors
#6
Fatemeh Tavanafar, Reza Safaralizadeh, Mohammad Ali Hosseinpour-Feizi, Behzad Mansoori, Dariush Shanehbandi, Ali Mohammadi, Behzad Baradaran
INTRODUCTION: Breast adenocarcinoma is the second common cancer in women the incidence of which is increasing in many countries, especially in developing companies. In this study, miRNA143 has been replaced by vector based microRNA-143 in breast adenocarcinoma cells (MDA-MB-468) and its anti-cancer effects on breast adenocarcinoma cells have been evaluated. METHODS: The pCMV-MIR-143 vector was transfected into MDA-MB-468 cells via JetPEI transfection reagent. The transfected cells were selected by IC50 concentration of Geneticin antibiotic (G418) after a 2-week treatment...
May 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28506082/novel-use-of-active-leptospermum-honey-for-ringed-fixator-pin-site-care-in-diabetic-charcot-deformity-patients
#7
Alexander L Lazarides, Kamran S Hamid, Michael S Kerzner
INTRODUCTION: Open reduction with external fixation (OREF) utilizing fine wire ringed fixators for correction of Charcot deformity has gained popularity over the past decade. Pin site infections are a well-documented complication of external fixation as well as a driver of escalating health care costs. We aimed to demonstrate the safety and efficacy of a novel method of pin site care utilizing active Leptospermum honey-impregnated dressings (MediHoney) in diabetic patients undergoing deformity correction with OREF...
May 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28499779/-treating-through-decision-and-follow-up-in-antibiotic-therapy-associated-exanthemas
#8
Axel Trautmann, Sandrine Benoit, Matthias Goebeler, Johanna Stoevesandt
BACKGROUND: Immediate discontinuation or replacement of suspected drugs is considered standard medical care in acute exanthematous skin reactions. In the treatment of bacterial infections, structurally different alternative antibiotics, however, are commonly second choice options due to a suboptimal antimicrobial activity or an unfavorable side effect profile. Nonetheless, "treating through," the continuation of antibiotic treatment despite an objective exanthema, is practiced only rarely...
May 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28498087/an-expert-opinion-on-pandas-pans-highlights-and-controversies
#9
Francesca Chiarello, Silvia Spitoni, Eric Hollander, Marco Matucci Cerinic, Stefano Pallanti
OBJECTIVES: 'Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections' (PANDAS) identified a unique subgroup of patients with abrupt onset of obsessive compulsive disorder (OCD) symptoms clinically related to Streptococcus infection and accompanied by neuropsychological and motor symptoms. After almost 20 years, PANDAS has not been accepted as distinct disorder and new criteria for paediatric acute-onset neuropsychiatric syndrome (PANS) have been replaced it, highlighting the fact that several agents rather than only Streptococcus might be involved...
February 13, 2017: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/28488117/fusion-expression-of-the-pgla-am1-with-native-structure-and-evaluation-of-its-anti-helicobacter-pylori-activity
#10
Xiaolin Zhang, Anmin Jiang, Guisheng Wang, Hao Yu, Banghua Qi, Youyi Xiong, Guoliang Zhou, Meisong Qin, Jinfeng Dou, Jianfei Wang
Helicobacter pylori (H. pylori) shows increasingly enhanced resistance to various antibiotics, and its eradication has become a major problem in medicine. The antimicrobial peptide PGLa-AM1 is a short peptide with 22 amino acids and exhibits strong antibacterial activity. In this study, we investigated whether it has anti-H. pylori activity for the further development of anti-H. pylori drugs to replace existing antibiotics. However, the natural antimicrobial peptide PGLa-AM1 shows a low yield and is difficult to separate, limiting its application...
May 10, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28486657/minimal-access-surgery-for-mitral-valve-endocarditis
#11
Cristina Barbero, Giovanni Marchetto, Davide Ricci, Samuel Mancuso, Massimo Boffini, Enrico Cecchi, Francesco Giuseppe De Rosa, Mauro Rinaldi
OBJECTIVES: Minimal access mitral valve surgery (MVS) has already proved to be feasible and effective with low perioperative mortality and excellent long-term outcomes. However, experience in more complex valve diseases such as infective endocarditis (IE) still remains limited. The aim of this retrospective study was to evaluate early and long-term results of minimal access MVS for IE. METHODS: Data were entered into a dedicated database. Analysis was performed retrospectively for the 8-year period between January 2007 and April 2015...
May 8, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28484827/-hot-rods-in-the-icu-what-is-the-antibiotic-mileage-of-your-renal-replacement-therapy
#12
REVIEW
J T Kielstein, A K Kruse, N Anderson, H Vaitiekunas, S Scherneck
We would neither be disappointed nor upset if the gas mileage on the sticker of a car didn't match our personal, real-life fuel consumption. Depending on our daily route to work, our style of accelerating and the number of passengers in our carpool, the gas mileage will vary. As soon as the falcon wing door of our car is closed and entrance to the ICU is granted, we tend to forget all of this, even though another hot rod is waiting there for us. Renal replacement therapy is like a car; it fulfills goals, such as the removal of uremic toxins and accumulated fluids, but it also "consumes" (removes) antibiotics...
May 8, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28482065/use-of-bacillus-subtilis-pb6-as-a-potential-antibiotic-growth-promoter-replacement-in-improving-performance-of-broiler-birds
#13
Sathishkumar Jayaraman, Partha Pratim Das, Prakash Chandra Saini, Barun Roy, Paresh Nath Chatterjee
The intestinal gut health is one of the primary determinants of broiler growth and performance. Among the various enteric diseases, necrotic enteritis (NE) is an enterotoxemic disease caused by Clostridium perfringens, which can result in severe economic losses in poultry farming. Antibiotics like bacitracin methylene disalicylate (BMD) and avilamycin (AVL) are commonly used antibiotic growth promoters (AGP) in poultry feed to control necrotic enteritis in birds. Bacillus subtilis PB6 was reported to prevent necrotic enteritis and improve performance in birds...
May 6, 2017: Poultry Science
https://www.readbyqxmd.com/read/28478834/3d-printed-liner-for-treatment-of-periprosthetic-joint-infections
#14
Tae Won B Kim, Osvaldo J Lopez, Jillian P Sharkey, Kyle R Marden, Muhammad Ridwan Murshed, Shivakumar I Ranganathan
In the United States, long standing deep infections of joint arthroplasty, such as total knee and total hip replacements, are treated with two-stage exchange. This requires the removal of the prior implant, placement of an antibiotic eluting spacer block made of polymethylmethacrylate (PMMA), followed by re-implantation of a new implant after treatment with intravenous antibiotics for six to eight weeks. Unfortunately, the use of PMMA as a spacer material has limitations in terms of mechanical and drug-eluting properties...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28472501/secondary-graft-oesophageal-fistula-after-total-arch-replacement%C3%A2
#15
Ken Yamanaka, Norihiko Shiiya, Naoki Washiyama, Masanori Sato
Secondary graft-oesophageal fistula is a fatal complication of aortic arch replacement. We report a successful two-stage surgical management of a graft-oesophageal fistula seen in a 68-year-old woman 3 years after total aortic arch replacement. She presented with a prolonged intractable fever without haematemesis. The fistula occurred between the distal aortic anastomosis and oesophagus; the entire graft was surrounded by air. In the first-stage operation, we performed re-replacement of the entire infected graft, oesophagectomy with cervical oesophagostomy, omental transfer and cervical routing of the stomach roll, through an extended left thoracotomy incision with sternal transection...
May 2, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28470270/biomimetic-synthesis-of-ag3po4-nps-cu-nws-with-visible-light-enhanced-photocatalytic-activity-for-degradation-of-the-antibiotic-ciprofloxacin
#16
Yuling Liu, Qingsheng Wu, Yaping Zhao
1D Ag3PO4-NPs/Cu-NWs have been constructed to enhance visible-light-driven photocatalytic activity via biomimetic synthesis. Cu nanowires (NWs) were synthesized by a facile hydrothermal method. During the process of biomimetic synthesis, the porous PTFE film, which can mimic the transport process of cell membranes, plays an important role in controlling the transport speed of silver ions (Ag(+)) to decrease the reaction speed. Thus inhibition of the replacement reaction of Ag(+)/Cu and the uniform growth of Ag3PO4 nanoparticles (NPs) with a diameter of about 10 nm on Cu-NWs can be realized simultaneously...
May 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28469945/osteomyelitis-of-the-mandible-after-dental-implants-in-an-immunocompetent-patient
#17
Matthieu Balanger, Margaux Hinet, Christian Vacher, Norbert Bellaiche, Jean-Luc Charrier, Sarah Millot
Dental implants are now broadly used to replace missing teeth, and the presence of infectious complications is rising. Dental implant therapy as a local risk factor for the onset of osteomyelitis and its management have not been widely explored. Here, we report an unusual case of mandibular suppurative osteomyelitis caused by Streptococcus intermedius in a healthy and immunocompetent patient secondary to mandibular implants. We describe how surgery combined with systemic application of antibiotics allowed conservation of the dental implants in the mandibular bone, discuss the probable source of contamination, and present the follow-up of the osteomyelitis...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/28469693/ruptured-sinus-of-valsalva-aneurysm-accompanied-by-aortic-and-tricuspid-valve-endocarditis-a-case-report
#18
Tahereh Davarpasand, Ali Hosseinsabet, Kyomars Abbasi
A ruptured sinus of Valsalva aneurysm rarely accompanies the aortic and tricuspid valve endocarditis. A 36-year-old woman presented with low-threshold dyspnea on exertion and fever. Transthoracic and transesophageal echocardiography showed a ruptured noncoronary sinus of Valsalva aneurysm with large vegetations on the tricuspid and aortic valves, resulting in moderately severe tricuspid regurgitation and severe aortic regurgitation. Blood culture was negative. The patient was initially treated with antibiotics and then subjected to the surgical repair of the sinus of Valsalva aneurysm and the tricuspid and aortic valve replacement...
January 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28469503/use-of-aminocaproic-acid-in-combination-with-extracorporeal-membrane-oxygenation-in-a-case-of-leptospirosis-pulmonary-hemorrhage-syndrome
#19
Miguel Pardinas, Rodrigo Mendirichaga, Gaurav Budhrani, Rajan Garg, Luis Rosario, Rene Rico, Anthony Panos, Horst Baier, Stefanie Krick
A 32-year-old man presented with a 10-day history of fever, chills, nausea, vomiting, myalgia, nonproductive cough, and worsening dyspnea after freshwater swimming in the Caribbean 1 week prior to presentation. Shortly after arrival at the hospital, the patient developed severe respiratory distress with massive hemoptysis. Based on serologic workup, he was diagnosed with leptospirosis pulmonary hemorrhage syndrome leading to diffuse alveolar hemorrhage, severe hypoxemic respiratory failure, and multiorgan failure...
2017: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/28466289/-personalised-pharmacotherapy-in-intensive-care-unit-patients
#20
R Bellmann
Critically ill patients need fast, effective and safe pharmacotherapy. The pharmacokinetics and pharmacodynamics of the administered drugs are influenced by numerous individual conditions. Genetic factors mainly determines drug metabolism. However, therapeutic decisions are not yet guided by genetic analyses. In elderly patients, the volume of distribution can be altered and renal elimination may be delayed. Drug-drug interactions involving current medications can increase the incidence of adverse effects from treatment in the intensive care unit...
May 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
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