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https://www.readbyqxmd.com/read/29679299/impact-of-computer-aided-ct-and-pet-analysis-on-non-invasive-t-staging-in-patients-with-lung-cancer-and-atelectasis
#1
Paul Flechsig, Ramin Rastgoo, Clemens Kratochwil, Ole Martin, Tim Holland-Letz, Alexander Harms, Hans-Ulrich Kauczor, Uwe Haberkorn, Frederik L Giesel
PURPOSE: Tumor delineation within an atelectasis in lung cancer patients is not always accurate. When T staging is done by integrated 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG)-positron emission tomography (PET)/X-ray computer tomography (CT), tumors of neuroendocrine differentiation and slowly growing tumors can present with reduced FDG uptake, thus aggravating an exact T staging. In order to further exhaust information derived from [18 F]FDG-PET/CT, we evaluated the impact of CT density and maximum standardized uptake value (SUVmax) for the classification of different tumor subtypes within a surrounding atelectasis, as well as possible cutoff values for the differentiation between the primary tumor and atelectatic lung tissue...
April 20, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29679088/complications-and-pain-in-obstructive-sleep-apnoea-comparing-single-and-multilevel-surgery
#2
Ching Yee Chan, Hong Juan Han, Weng Kit Lye, Song Tar Toh
INTRODUCTION: This study aimed to investigate differences in the complication rate and postoperative pain score between single and multilevel surgery performed on patients with obstructive sleep apnoea. MATERIALS AND METHODS: A retrospective analysis was performed on patients with obstructive sleep apnoea who underwent surgery in a tertiary referral centre over 3 years. Patients who underwent single-level nasal, palatal or tongue surgery were compared with patients who underwent concurrent multilevel surgery of 2 or 3 levels...
March 2018: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29678358/impact-of-68-ga-psma-pet-on-the-management-of-patients-with-prostate-cancer-a-systematic-review-and-meta-analysis
#3
REVIEW
Sangwon Han, Sungmin Woo, Yeon Joo Kim, Chong Hyun Suh
CONTEXT: 68 Gallium prostate-specific membrane antigen positron emission tomography (68 Ga-PSMA PET) is an emerging imaging modality for assessment of prostate cancer. Recent studies show promising results regarding its ability to detect recurrent or metastatic prostate cancer superior to that of conventional imaging modalities. However, the impact of 68 Ga-PSMA PET on management of patients with prostate cancer has not been well established. OBJECTIVE: To perform a systematic review and meta-analysis to evaluate the impact of 68 Ga-PSMA PET on management of patients with prostate cancer...
April 17, 2018: European Urology
https://www.readbyqxmd.com/read/29678268/development-of-a-screening-tool-to-predict-chronic-kidney-disease-risk-in-post-nephrectomy-living-kidney-donors
#4
J S Park, H K Ahn, J Na, H H Lee, Y E Yoon, M G Yoon, W K Han
Few studies have examined the long-term risks of kidney removal to donors despite the increase of frequency in kidney transplantation. This is the 1st study to develop prediction models of chronic kidney disease (CKD) for the 1-year period after donor nephrectomy in living donors. A prospective cohort of patients who underwent donor nephrectomy from March 1, 2006, to December 31, 2016, at the Severance Hospital, Seoul, South Korea, was used. CKD was defined as a glomerular filtration rate (GFR) <60 mL/min/1...
April 17, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29676809/prevalence-of-maternal-birth-trauma-in-nepali-women
#5
Friyan Turel, Delena Caagbay, Hans Peter Dietz
OBJECTIVES: Pelvic organ prolapse is very common among women in Nepal, especially uterine prolapse. This would suggest a high rate of levator trauma, which is a strong predictor of such prolapse in the Western world. Hence, we decided to study the prevalence of maternal birth trauma in Nepali women. METHODS: In November 2016, we offered an interview, clinical examination, and 4-dimensional translabial sonography to women attending a gynecology clinic. Of 129 women seen, 5 were excluded due to previous pelvic surgery...
April 20, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29675348/clinical-histopathology-of-intrachoroidal-splitting-in-open-globe-injury-a-retrospective-case-series-of-four-patients
#6
Liang Han, Yen-Ling Cho, Zhizhong Ma, Xinrong Zhao, Xin Chang
PURPOSE: The purpose of this study is to observe the characteristics of intrachoroidal splitting (ICS) associated with choroidal detachment due to open-globe injury. METHODS: A retrospective, observational case series study of four eyes diagnosed with choroidal detachment exhibited ICS. The in vivo pathologic changes of the ICS were recorded during surgery. Four specimens were obtained from the inner part of the ICS region. One specimen was stained with hematoxylin and eosin; one specimen was examined under scanning electron microscopy, and the other two specimens were examined under transmission electron microscopy...
January 2018: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29672782/-comparison-of-the-regenerative-cytokine-profile-of-adipose-derived-stromal-cells-ascs-harvested-via-abdominoplasty-suction-assisted-liposuction-sal-and-ultrasound-assisted-liposuction-ual
#7
Matthias Michael Aitzetmüller, Hans-Günther Machens, Arndt F Schilling, Dominik Duscher
INTRODUCTION: Mesenchymal stem cells are already used in numerous areas of medicine. In the field of plastic surgery, the main focus of recent research has been to utilise adipose-derived stromal cells (ASCs), mainly harvested via liposuction. The ability to release regenerative cytokines is supposed to be the key mechanism for the therapeutic efficacy of ASCs. There are currently a variety of methods and devices in clinical use for harvesting lipoaspirate and consequently ASCs. For most of these devices, the effect on the regenerative cytokine profile of ASCs is unknown...
April 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29672726/a-new-surgical-strategy-for-medically-uncontrolled-protein-losing-enteropathy-after-fontan-surgery
#8
Seul Gi Cha, Gi Beom Kim, Chung Noh, Woong Han Kim
Managing protein-losing enteropathy after Fontan surgery is challenging. We report a case of protein-losing enteropathy associated with Fontan circulation in a 14-year-old boy. He was treated medically for 2 years, without improvement until Fontan takedown and pulsatile bidirectional cavopulmonary shunting were performed.
April 16, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29671874/pain-assessment-by-pupil-dilation-reflex-in-response-to-noxious-stimulation-in-anaesthetized-adults
#9
D Wildemeersch, N Peeters, V Saldien, M Vercauteren, G Hans
BACKGROUND: In response to noxious stimulation, pupillary dilation reflex (PDR) occurs even in anaesthetized patients. The aim of the study was to evaluate the ability of pupillometry with an automated increasing stimulus intensity to monitor intraoperative opioid administration. METHODS: Thirty-four patients undergoing elective surgery were enrolled. Induction by propofol anaesthesia was increased progressively until the sedation depth criteria (SeD) were attained...
April 19, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29669701/crizotinib-in-patients-with-advanced-inoperable-inflammatory-myofibroblastic-tumours-with-and-without-anaplastic-lymphoma-kinase-gene-alterations-european-organisation-for-research-and-treatment-of-cancer-90101-create-a-multicentre-single-drug-prospective-non
#10
Patrick Schöffski, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Sandra J Strauss, Silvia Stacchiotti, Piotr Rutkowski, Lars H Lindner, Michael G Leahy, Antoine Italiano, Nicolas Isambert, Maria Debiec-Rychter, Raf Sciot, Thomas Van Cann, Sandrine Marréaud, Axelle Nzokirantevye, Sandra Collette, Agnieszka Wozniak
BACKGROUND: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. METHODS: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK)...
April 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29668992/pediatric-temporal-lobe-epilepsy-surgery-in-bonn-and-review-of-the-literature
#11
D Ryan Ormond, Hans Clusmann, Robert Sassen, Christian Hoppe, Christoph Helmstaedter, Johannes Schramm, Alexander Grote
BACKGROUND: Epilepsy surgery is well established as safe and successful for children with temporal lobe epilepsy (TLE). Despite evidence from available data, there remains some reluctance to refer children with medically refractory epilepsy for preoperative evaluation and workup for possible surgery. OBJECTIVE: To present the largest case series of pediatric (TLE) patients thus far, in order to better understand the predictability of preoperative evaluation on seizure outcome, and to better understand longitudinal outcomes in a large pediatric cohort...
April 13, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29668618/postoperative-course-of-crohn-disease-according-to-timing-of-bowel-resection-results-from-the-connect-study
#12
Ji Min Lee, Kang-Moon Lee, Joo Sung Kim, You Sun Kim, Jae Hee Cheon, Byong Duk Ye, Young-Ho Kim, Dong Soo Han, Chang Kyun Lee, Hyun-Ju Park
Previous studies have demonstrated that early surgery in Crohn disease (CD) can result in a better clinical course than late surgery. The aim of this study was to compare the clinical course of CD following bowel resection performed at the time of diagnosis (early surgery) and during the course of the disease (late surgery).We reviewed medical records from a hospital-based cohort database that includes Korean CD patients diagnosed before 2009. Patients who underwent bowel resection were included. Age, sex, disease phenotype, time of surgery, medication history including use of corticosteroids, immunomodulators, and biologics, and further surgical history were assessed...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29668608/optimal-dose-of-perineural-dexmedetomidine-for-interscalene-brachial-plexus-block-to-control-postoperative-pain-in-patients-undergoing-arthroscopic-shoulder-surgery-a-prospective-double-blind-randomized-controlled-study
#13
Hong Soo Jung, Kwon Hui Seo, Jae Hyuk Kang, Jin-Young Jeong, Yong-Shin Kim, Na-Re Han
BACKGROUND: Adjuvant perineural dexmedetomidine can be used to prolong the analgesic effect of interscalene brachial plexus block (ISB). We investigated the optimal dose of dexmedetomidine in ISB for postoperative analgesia in patients undergoing arthroscopic shoulder surgery. METHODS: One hundred patients scheduled for elective shoulder arthroscopic surgery were enrolled in this randomized, double-blind study. Ultrasound-guided ISB was performed before general anesthesia using 22 mL of ropivacaine 0...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29663766/kirurgisk-behandling-av-pylorusstenose
#14
Kaja Mørk, Hans Skari, Ole Schistad, Pål Aksel Næss
BACKGROUND: Pyloric stenosis is one of the most common surgical conditions in infants. This study aims to investigate diagnostics and results of surgical treatment for pyloric stenosis at Oslo University Hospital Ullevål. MATERIAL AND METHOD: A retrospective review of patient records for those undergoing surgery for pyloric stenosis in the period 2004-2016 was conducted. Preoperative symptoms and findings, diagnostics, treatment and postoperative results were recorded...
April 17, 2018: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
https://www.readbyqxmd.com/read/29662932/combined-extensive-esophageal-squamous-papillomas-and-florid-cardiac-gland-hyperplasia-in-a-patient-with-adenocarcinoma
#15
Takanori Suganuma, Han-Seung Yoon
We report a rare case of extensive esophageal squamous papillomas (ESPs) involving the entire esophagus and florid cardiac gland hyperplasia involving only the lower esophagus in a 39-year-old woman with heartburn and epigastric distress for the past 2 years. Previous esophagogastroduodenoscopy showed multiple ESPs involving the entire esophagus extending 38 cm from the esophageal orifice to the esophagogastric junction (EGJ). Additionally, prominent cardiac gland hyperplasia over the esophageal posterior wall was exhibited extending 12 cm from the mid-esophagus to the EGJ...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29661289/a-nomogram-to-predict-lymph-node-metastasis-before-resection-in-intrahepatic-cholangiocarcinoma
#16
Ze-Wu Meng, Xiu-Quan Lin, Jin-Hai Zhu, Sheng-Hua Han, Yan-Ling Chen
BACKGROUND: In this study, we developed and validated a nomogram to predict lymph node metastasis before surgery in patients with intrahepatic cholangiocarcinoma (ICC). METHODS: Using the data from January 2006 to January 2015, we enrolled a total of 218 eligible patients with clinicopathologically confirmed ICC as a primary cohort to develop the nomogram. After various variables before surgery were analyzed by multivariable logistic regression, we combined the preoperative carbohydrate antigen 19-9, primary site of tumor, lymphonodus size on computed tomography imaging, tumor growth pattern, and (if applicable) histologic grade to make two different predictive nomograms...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29657902/inhibitory-effects-of-angiotensin-ii-receptor-blockade-on-human-tenon-fibroblast-migration-and-reactive-oxygen-species-production-in-cell-culture
#17
Duri Kim, Ushasree Pattamatta, Elizabeth Kelly, Paul R Healey, Nicole Carnt, Hans Zoellner, Andrew J R White
Purpose: We investigate the effect of angiotensin receptor blockade on the migration of human Tenon fibroblasts (HTF), using irbesartan, an angiotensin II receptor type 1 (AT1R) blocker (ARB) as a potential antifibrotic agent in glaucoma filtration surgery. Methods: Confluent HTF cultures were scratched with a 1 mL pipette tip and treated with either irbesartan (10, 50, and 100 μg/mL) or angiotensin II (2 μg/mL). The extent of HTF migration up to 30 hours, and cell number and morphology at 72 hours was evaluated...
April 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29652755/comprehensive-treatment-and-rehabilitation-of-patients-with-osteosarcoma-of-the-mandible
#18
Anatolij Sergeevich Utyuzh, Alexei Valerievich Yumashev, Hans Walter Lang, Angelina Olegovna Zekiy, Richard Michailovich Lushkov
OBJECTIVE: The article studies state-of-the art physical therapeutic techniques as a high degree of relevance to minimize invalidation and improve quality of life for patients with dental osteosarcoma. MATERIALS AND METHODS: A randomized controlled clinical trial was conducted in 21 patients with osteogenic sarcoma of mandible (C41.1). There were 10 patients in the experimental group and 11 patients in the control group. RESULTS: A comprehensive treatment and rehabilitation program for patients with osteosarcoma of mandible was developed...
April 12, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29651610/periprosthetic-femoral-fracture-as-cause-of-early-revision-after-short-stem-hip-arthroplasty-a-multicentric-analysis
#19
Sang-Min Kim, Seung-Beom Han, Kee Hyung Rhyu, Jeong Joon Yoo, Kwang-Jun Oh, Je Hyun Yoo, Kyung-Jae Lee, Seung-Jae Lim
BACKGROUND: The objective of this study was to analyze the prevalence and causes of early re-operation after hip replacement surgery using short bone-preserving stems in a large multicentre series. Specifically, we evaluated the clinical features of periprosthetic fractures occurring around short stems. METHODS: A total of 897 patients (1089 hips) who underwent primary total hip arthroplasty or bipolar hemiarthroplasty from January 2011 to February 2015 using short bone-preserving femoral stems were recruited...
April 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29650420/denosumab-treatment-of-inoperable-or-locally-advanced-giant-cell-tumor-of-bone-multicenter-analysis-outside-clinical-trial
#20
Piotr Rutkowski, Louie Gaston, Aneta Borkowska, Silvia Stacchiotti, Hans Gelderblom, Giacomo Giulio Baldi, Emanuela Palmerini, Paolo Casali, Alessandro Gronchi, Michael Parry, Domenico Andrea Campanacci, Guido Scoccianti, Michal Wagrodzki, Stefano Ferrari, Sander Dijkstra, Andrzej Pieńkowski, Robert Grimer
BACKGROUND: Giant cell tumor of bone (GCTB) is an osteolytic, locally aggressive, rarely metastazing bone tumor. This is a retrospective study evaluating a large series of GCTB patients treated with denosumab in routine practice in 6 European reference centers. METHODS: Patients with locally advanced, unresectable or metastatic GCTB, treated with denosumab outside clinical trials were eligible. Primary end-point was progression-free survival (PFS) for all patients; secondary end-points were: type of surgery, relapse rate and event-free survival for patients after preoperative denosumab + surgery...
March 31, 2018: European Journal of Surgical Oncology
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