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https://www.readbyqxmd.com/read/29471107/pick1-deficiency-exacerbates-sepsis-associated-acute-lung-injury-and-impairs-glutathione-synthesis-via-reduction-of-xct
#1
Meizi Qian, Yingying Lou, Yixiu Wang, Minyuan Zhang, Qun Jiang, Yunchang Mo, Kunyuan Han, Shenhui Jin, Qinxue Dai, Yulong Yu, Zhen Wang, Junlu Wang
The role of oxidative stress has been well documented in the development of sepsis-induced acute lung injury (ALI). Protein interaction with C-kinase 1 (PICK1) participates in oxidative stress-related neuronal diseases. However, its function in lung infections and inflammatory diseases is not known. We therefore sought to investigate whether PICK1 is involved in sepsis-induced ALI. Cecal ligation and puncture (CLP) was performed in anesthetized wild type (WT) and PICK1 knock out (KO, PICK1-/- ) mice with C57BL/6 background...
February 19, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29470095/subacromial-local-anesthetics-do-not-interfere-with-rotator-cuff-healing-after-arthroscopic-repair
#2
Sung-Min Rhee, Nam Yun Chung, Hyeon Jang Jeong, Joo Han Oh
BACKGROUND: Subacromial pain pumps are used for analgesia after arthroscopic rotator cuff surgery. However, there is controversy about myotoxic or tendinotoxic effects of local anesthetics. HYPOTHESIS: Ropivacaine administered via a subacromial pain pump would have no adverse effect on rotator cuff tendon healing, fatty degeneration, strength, or functional outcomes after arthroscopic repair. STUDY DESIGN: Cohort study; Level of evidence, 3...
February 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29467591/whole-exome-sequencing-reveals-novel-somatic-alterations-in-neuroblastoma-patients-with-chemotherapy
#3
Chao Duan, Han Wang, Ying Chen, Ping Chu, Tianyu Xing, Chao Gao, Zhixia Yue, Jie Zheng, Mei Jin, Weiyue Gu, Xiaoli Ma
Background: We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy. Methods: Marrow blood samples from NB patients were collected before treatment, after the 2nd and 4th chemotherapy for baseline research and continuous monitoring by whole exome sequencing. Plasma cell free DNA (cfDNA) was prepared for baseline research. Finger nail cells were extracted as self control. The clinical data was analyzed...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29467088/do-reduced-copayments-affect-mortality-after-surgery-due-to-stroke-an-interrupted-time-series-analysis-of-a-national-cohort-sampled-in-2003-2012
#4
Kyu-Tae Han, Seung Ju Kim, Sun Jung Kim, Ji Won Yoo, Eun-Cheol Park
BACKGROUND: The South Korean government introduced a policy in 2 phases, in September 2005 and in January 2010, for reducing copayments for patients with critical diseases, including stroke, to prevent excessive medical expenditures and to ease economic barriers. Previous studies of the effect of this policy were focused primarily on cancer. Therefore, we investigated the relationship between this policy and 1-year mortality after surgery among patients with stroke. METHODS: We used data from the Korean National Health Insurance sampling cohort (n = 2173 in 2003-2012) and performed an interrupted time series analysis...
February 19, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29466929/histological-scoring-method-to-assess-bone-healing-in-critical-size-bone-defect-models
#5
Zhihua Han, Mit Bhavsar, Liudmila Leppik, Karla M C Oliveira, John H Barker
Large bone defects are a major problem in trauma and orthopedic surgery. Tissue engineering based treatments have emerged as promising alternatives of traditional bone grafting techniques. Critical size bone defect animal models had been developed and widely used to evaluate and compare therapeutic effectiveness in bone tissue engineering treatments. To measure healing in a given defect, after treatment histological assessment methods are commonly used. These histological methods are typically either qualitative and/or measure the amount of newly formed bone...
February 21, 2018: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/29465567/measurement-of-the-nerve-root-of-the-lower-lumbar-region-using-digital-images
#6
Xin Zhao, Jie Zhao, Jie Guan, Junkai Zeng, Chen Han, Yuzhou He, Tangjun Zhou, Chen Chen, Youzhuan Xie
The purpose of this study was to evaluate the relationship between the nerve root of lower lumbar and the surrounding structures using three-dimensional computed tomography (3D CT).Twenty-three consecutive patients with thoracolumbar fractures without obvious radiological degeneration were retrospectively studied at the spinal surgery department of the hospital. The parameters of the relationship between the nerve root of the lower lumbar and the surrounding structures were measured using 3D CT in the work station of the picture archiving and communication system...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465544/the-choose-of-different-surgical-therapies-of-hepatic-alveolar-echinococcosis-a-single-center-retrospective-case-control-study
#7
Ke-Fei Chen, You-Yin Tang, Rui Wang, Dan Fang, Jun-Hua Chen, Yong Zeng, Bo Li, Tian-Fu Wen, Wen-Tao Wang, Hong Wu, Ming-Qing Xu, Jia-Yin Yang, Yong-Gang Wei, Ji-Wei Huang, Jia-Xin Li, Han-Zhi Zhang, Xi Feng, Lü-Nan Yan, Zhe-Yu Chen
The aim of this study was to evaluate different surgical therapies for hepatic alveolar echinococcosis in different clinical stages.We analyze the clinical data of 115 patients who received surgical treatment in West China Hospital from January 2004 to June 2016. Among these patients, 77 cases underwent radical hepatic resection (group A, n = 77); 17 cases underwent palliative resection (group B, n = 17), and 21 cases underwent liver transplantation (group C, n = 21) with 12 cases of orthotopic liver transplantation and 9 cases of liver autotransplantation...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465283/augmented-reality-in-dentistry-a-current-perspective
#8
Ho-Beom Kwon, Young-Seok Park, Jung-Suk Han
Augmentation reality technology offers virtual information in addition to that of the real environment and thus opens new possibilities in various fields. The medical applications of augmentation reality are generally concentrated on surgery types, including neurosurgery, laparoscopic surgery and plastic surgery. Augmentation reality technology is also widely used in medical education and training. In dentistry, oral and maxillofacial surgery is the primary area of use, where dental implant placement and orthognathic surgery are the most frequent applications...
February 21, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29463840/cranial-shape-comparison-for-automated-objective-3d-craniosynostosis-surgery-planning
#9
Manon L Tolhuisen, Guido A de Jong, Ruud J M van Damme, Ferdinand van der Heijden, Hans H K Delye
Virtual planning of open cranial vault reconstruction is used to simulate and define an pre-operative plan for craniosynostosis surgery. However, virtual planning techniques are subjective and dependent on the experience and preferences of the surgical team. To develop an objective automated 3D pre-operative planning technique for open cranial vault reconstructions, we used curvature maps for the shape comparison of the patient's skull with an age-specific reference skull. We created an average skull for the age-group of 11-14 months...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463493/effect-of-impulsive-compression-treatment-on-postoperative-complications-after-open-peripheral-vascular-revascularization-in-situ-protocol-for-a-randomized-control-trial
#10
Tenna Klit, Marie Dahl, Kim Christian Houlind, Hans Ravn
BACKGROUND: In patients with critical leg ischemia (CLI), the standard operative choice is an in situ bypass to the lower extremity to improve the patients´ prognosis and quality of life. Postoperative complications after surgery occur in 18 % of the patients, prolonging hospitalization and convalescence. The main operative complication is edema. This can be prevented by early mobilization or stimulation of the natural venous pump in the leg. OBJECTIVE: To investigate whether compression therapy with foot pump reduces postoperative edema, facilitates wound healing of the operation wounds, promotes healing of ischemic ulcers, and shortens hospitalization, increasing and improving the patient's subjective quality of life faster...
February 20, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29463159/prophylactically-applied-hydrofilm-polyurethane-film-dressings-reduce-radiation-dermatitis-in-adjuvant-radiation-therapy-of-breast-cancer-patients
#11
Leonard Christopher Schmeel, David Koch, Sabina Stumpf, Christina Leitzen, Birgit Simon, Heinrich Schüller, Susanne Vornholt, Felix Schoroth, Thomas Müdder, Fred Röhner, Stephan Garbe, Frederic Carsten Schmeel, Hans Heinz Schild, Timo Martin Wilhelm-Buchstab
PURPOSE: Radiation-induced skin injury represents one of the most common side effects in breast cancer patients receiving adjuvant whole-breast radiotherapy. Numerous systemic and topical treatments have been studied in the prevention and management of radiation-induced skin injury without providing sustainable treatment strategies. While superficial barrier-forming skin products such as dressings are the standard of care in wound care management, their utilization as preventive treatment approach in radiotherapy has barely attracted attention...
February 20, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29462807/the-return-of-fear-variation-of-the-serotonin-transporter-gene-predicts-outcome-of-a-highly-standardized-exposure-based-one-session-fear-treatment
#12
André Wannemüller, Dirk Moser, Robert Kumsta, Hans-Peter Jöhren, Jürgen Margraf
BACKGROUND: Methodological problems of existing research, such as the application of unstandardized treatments in heterogeneous samples, has hampered clear conclusions about the extent and direction to which allelic variation of the serotonin transporter gene-linked polymorphic region (5- HTTLPR) is associated with a differential response to psychological treatment. The present study aimed to investigate the effects of the 5-HTTLPR genotype on treatment outcome under highly standardized environmental conditions...
February 21, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29462071/the-relationship-between-improvements-in-myelopathy-and-sagittal-realignment-in-cervical-deformity-surgery-outcomes
#13
Peter Gust Passias, Samantha R Horn, Cole A Bortz, Subaraman Ramachandran, Douglas C Burton, Themistocles Protopsaltis, Renaud Lafage, Virginie Lafage, Bassel G Diebo, Gregory W Poorman, Frank A Segreto, Justin S Smith, Christopher Ames, Christopher I Shaffrey, Han Jo Kim, Brian Neuman, Alan H Daniels, Alexandra Soroceanu, Eric Klineberg
STUDY DESIGN: Retrospective review. OBJECTIVE: Determine if alignment or myelopathy improvement drives patient outcomes following cervical deformity(CD) corrective surgery. SUMMARY OF BACKGROUND DATA: CD correction involves radiographic malalignment correction and procedures to improve motor function and pain. It is unknown whether alignment or myelopathy improvement drives patient outcomes. METHODS: Inclusion: CD patients with baseline/1-year radiographic and outcome scores...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29462005/oncological-benefits-of-neoadjuvant-chemoradiation-with-gemcitabine-versus-upfront-surgery-in-patients-with-borderline-resectable-pancreatic-cancer-a-prospective-randomized-open-label-multicenter-phase-2-3-trial
#14
Jin-Young Jang, Youngmin Han, Hongeun Lee, Sun-Whe Kim, Wooil Kwon, Kyung-Hun Lee, Do-Youn Oh, Eui Kyu Chie, Jeong Min Lee, Jin Seok Heo, Joon Oh Park, Do Hoon Lim, Seong Hyun Kim, Sang Jae Park, Woo Jin Lee, Young Hwan Koh, Joon Seong Park, Dong Sup Yoon, Ik Jae Lee, Seong Ho Choi
OBJECTIVE: This study was performed to determine whether neoadjuvant treatment increases survival in patients with BRPC. SUMMARY BACKGROUND DATA: Despite many promising retrospective data on the effect of neoadjuvant treatment for borderline resectable pancreatic cancer (BRPC), no high-level evidence exists to support the role of such treatment. METHODS: This phase 2/3 multicenter randomized controlled trial was designed to enroll 110 patients with BRPC who were randomly assigned to gemcitabine-based neoadjuvant chemoradiation treatment (54 Gray external beam radiation) followed by surgery or upfront surgery followed by chemoradiation treatment from four large-volume centers in Korea...
February 16, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29461371/facial-artery-as-a-recipient-vessel-for-extensive-scalp-reconstruction-with-free-omental-flap-without-vein-graft
#15
Jin Woo Kim, Soo Hyun Woo, Suk Yoon Jang, Woo Seob Kim, Tae Hui Bae, Han Koo Kim
Most patients with reconstruction for extensive scalp defects require the use of a free flap. The suitability of the recipient vessel has a major impact on the surgery and postoperative outcome. Flaps that can be used to reconstruct the total scalp with a single flap include the latissimus dorsi (LD) and omental flaps; the LD flap is generally preferred since the omental flap results in relatively larger donor site morbidity. The recipient vessel most commonly used for scalp defect reconstruction is the superficial temporal vessel...
February 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29460013/eurospine-2017-full-paper-award-time-to-remove-our-rose-tinted-spectacles-a-candid-appraisal-of-the-relative-success-of-surgery-in-over-4500-patients-with-degenerative-disorders-of-the-lumbar-spine-hip-or-knee
#16
Anne F Mannion, Franco M Impellizzeri, Michael Leunig, Dezsö Jeszenszy, Hans-Jürgen Becker, Daniel Haschtmann, Stefan Preiss, Tamas F Fekete
PURPOSE: Studies comparing the outcome of spine surgery with that of large-joint replacement report equivocal findings. The patient-reported outcome measures (PROMs) used in such studies are typically generic and may not be sufficiently sensitive to the successes/failures of treatment. This study compared different indices of "success" in patients undergoing surgery for degenerative disorders of the lumbar spine, hip, or knee, using a validated, multidimensional, and joint-specific PROM...
February 19, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29459997/the-effects-of-intra-arterial-chemotherapy-on-bladder-preservation-in-patients-with-t1-stage-bladder-cancer
#17
Zefu Liu, Yunlin Ye, Xiangdong Li, Shengjie Guo, Lijuan Jiang, Pei Dong, Yonghong Li, Yanxia Shi, Weijun Fan, Yun Cao, Kai Yao, Zike Qin, Hui Han, Fangjian Zhou, Zhuowei Liu
PURPOSE: To investigate the effects of intra-arterial chemotherapy on T1 stage bladder cancer (Bca) and evaluate patient outcome with bladder-preserving treatment approaches. MATERIALS AND METHODS: A total of 238 patients with T1 stage Bca were retrospectively analyzed. Among them, 35 patients were categorized into the subgroup of highest-risk T1 stage according to the European Association of Urology guidelines and received immediate radical cystectomy (RC group), whereas 62 were classified as being highest-risk T1 patients but were unwilling to undergo RC and were treated with gemcitabine plus cisplatin intra-arterial chemotherapy (GC group)...
February 19, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29459018/prognostic-significance-of-18-f-fdg-pet-ct-in-patients-with-colorectal-cancer-liver-metastases-after-hepatectomy
#18
Jae-Ryong Shim, Seung Duk Lee, Sung-Sik Han, Sang Jae Lee, Dong Eun Lee, Seok-Ki Kim, Seong Hoon Kim, Sang Jae Park, Jae-Hwan Oh
INTRODUCTION: Colorectal cancer liver metastasis (CRLM) can be cured with surgery. To improve survival, optimal selection of CRLM patients should be done cautiously, which may be facilitated by preoperative [F-18] fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT). METHODS: A total of 245 patients with CRLM between February 2007 and January 2015 were retrospectively studied. All clinical variables, pathological data, and various PET/CT parameters were correlated with disease-free survival (DFS) and overall survival (OS)...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29458183/age-dependent-attitudes-of-ischemic-patients-towards-disability-after-decompressive-hemicraniectomy-for-malignant-middle-cerebral-artery-infarction
#19
Byoung-Joon Kim, Yeon Ran Hong, Youngmin Han, Yang-Ha Hwang, Boram Ohk, Jaechan Park
OBJECTIVE: To improve the process of surgical informed consent, patient attitudes towards acceptable levels of disability after decompressive surgery for malignant middle cerebral artery infarction are investigated, including the impact of patient age. METHODS: Patients who had experienced a recent minor stroke were asked to complete a questionnaire comprised of 2 parts: 1) demographic information, including patient age, gender, years of education, working status, religion, and economic status and 2) acceptable level of disability based on a modified Rankin Scale (mRS) with corresponding illustrations to explain the mRS levels...
February 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29456912/dural-tears-in-adult-deformity-surgery-incidence-risk-factors-and-outcomes
#20
Sravisht Iyer, Eric O Klineberg, Lukas P Zebala, Michael P Kelly, Robert A Hart, Munish C Gupta, D Kojo Hamilton, Gregory M Mundis, Daniel Sciubba, Christopher P Ames, Justin S Smith, Virginie Lafage, Douglas Burton, Han Jo Kim
Study Design: Retrospective cohort study. Objectives: Describe the rate of dural tears (DTs) in adult spinal deformity (ASD) surgery. Describe the risk factors for DT and the impact of this complication on clinical outcomes. Methods: Patients with ASD undergoing surgery between 2008 and 2014 were separated into DT and non-DT cohorts; demographics, operative details, radiographic, and clinical outcomes were compared. Statistical analysis included t tests or χ2 tests as appropriate and a multivariate analysis...
February 2018: Global Spine Journal
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