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Low tension glaucoma

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https://www.readbyqxmd.com/read/29726764/letter-to-the-editor-low-icp-and-normal-tension-glaucoma-optic-nerve-damage-due-to-barotraumatic-factors-failure-of-csf-dynamics-or-both
#1
Peter Wostyn, Veva De Groot, Debby Van Dam, Kurt Audenaert, Peter Paul De Deyn, Hanspeter Esriel Killer
No abstract text is available yet for this article.
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651628/intracranial-and-intraocular-pressure-at-the-lamina-cribrosa-gradient-effects
#2
REVIEW
Gauti Jóhannesson, Anders Eklund, Christina Lindén
PURPOSE OF REVIEW: A pressure difference between the intraocular and intracranial compartments at the site of the lamina cribrosa has been hypothesized to have a pathophysiological role in several optic nerve head diseases. This paper reviews the current literature on the translamina cribrosa pressure difference (TLCPD), the associated pressure gradient, and its potential pathophysiological role, as well as the methodology to assess TLCPD. RECENT FINDINGS: For normal-tension glaucoma (NTG), initial studies indicated low intracranial pressure (ICP) while recent findings indicate that a reduced ICP is not mandatory...
April 12, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29606853/the-role-of-corneal-hysteresis-during-the-evaluation-of-patients-with-possible-normal-tension-glaucoma
#3
Ming Chen, Laura Kueny, Arthur L Schwartz
Purpose: There are multiple reports of the role of corneal hysteresis (CH) as an independent risk factor for the diagnosis and risk of progression of normal-tension glaucoma (NTG). Our study measured CH with the Ocular Response Analyzer (ORA) in patients with intraocular pressure (IOP) <21 mmHg to investigate if a low CH would identify NTG in this Asian-based practice. Methods: This was a prospective cross-sectional study of patients who underwent routine eye examination during 2016 in a private practice in Honolulu, Hawaii, where most patients are Asian...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29491486/low-nocturnal-diastolic-ocular-perfusion-pressure-as-a-risk-factor-for-ntg-progression-a-5-year-prospective-study
#4
Pushpa Raman, Nurull Bahya Suliman, Mimiwati Zahari, Michael Kook, Norlina Ramli
OBJECTIVE: To assess the relationship between baseline intraocular pressure (IOP), blood pressure (BP) and ocular perfusion pressure (OPP), and the 5-year visual field progression in normal-tension glaucoma (NTG) patients. DESIGN: Prospective, longitudinal study. METHODS: Sixty-five NTG patients who were followed up for 5 years are included in this study. All the enrolled patients underwent baseline 24-h IOP and BP monitoring via 2-hourly measurements in their habitual position and were followed up for over 5 years with reliable VF tests...
March 1, 2018: Eye
https://www.readbyqxmd.com/read/29236748/the-diagnostic-use-of-choroidal-thickness-analysis-and-its-correlation-with-visual-field-indices-in-glaucoma-using-spectral-domain-optical-coherence-tomography
#5
Zhongjing Lin, Shouyue Huang, Ping Huang, Lei Guo, Xi Shen, Yisheng Zhong
PURPOSE: To evaluate the quantitative characteristics of choroidal thickness in primary open-angle glaucoma (POAG), normal tension glaucoma (NTG) and in normal eyes using spectral-domain optical coherence tomography (SD-OCT). To evaluate the diagnostic ability of choroidal thickness in glaucoma and to determine the correlation between choroidal thickness and visual field parameters in glaucoma. METHODS: A total of 116 subjects including 40 POAG, 30 NTG and 46 healthy subjects were enrolled in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29179746/association-of-interleukin-1-gene-clusters-polymorphisms-with-primary-open-angle-glaucoma-a-meta-analysis
#6
Junhua Li, Yifan Feng, Mi Sun Sung, Tae Hee Lee, Sang Woo Park
BACKGROUND: Previous studies have associated the Interleukin-1 (IL-1) gene clusters polymorphisms with the risk of primary open-angle glaucoma (POAG). However, the results were not consistent. Here, we performed a meta-analysis to evaluate the role of IL-1 gene clusters polymorphisms in POAG susceptibility. METHODS: PubMed, EMBASE and Cochrane Library (up to July 15, 2017) were searched by two independent investigators. All case-control studies investigating the association between single-nucleotide polymorphisms (SNPs) of IL-1 gene clusters and POAG risk were included...
November 28, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29109895/are-all-retinal-nerve-fiber-layer-defects-on-optic-coherence-tomography-glaucomatous
#7
Sirel Gür Güngör, Akman Ahmet
Objectives: In this study, we investigated the patients who were referred to our clinic with a prediagnosis of glaucoma based on retinal nerve fiber layer (RNFL) defects on optic coherence tomography (OCT) but were determined to have nonglaucomatous RNLF defects upon detailed examination. Materials and Methods: The ophthalmic examination notes, OCT images, Heidelberg retinal tomography (HRT) II and fundus photographs of 357 patients were retrospectively evaluated...
October 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29098083/an-analysis-of-3-year-outcomes-following-canaloplasty-for-the-treatment-of-open-angle-glaucoma
#8
Mahmoud A Khaimi, Justin D Dvorak, Kai Ding
Purpose: To report 3-year results investigating the safety and efficacy of canaloplasty for open-angle glaucoma. Setting: University of Oklahoma, Dean McGee Eye Institute, Oklahoma, United States of America. Design: Nonrandomized single-center retrospective chart review. Methods: Adult open-angle glaucoma eyes underwent canaloplasty or combined cataract-canaloplasty surgery. A tensioning suture was placed into Schlemm's canal in all eyes...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29096996/normal-tension-glaucoma-has-normal-intracranial-pressure-a-prospective-study-of-intracranial-pressure-and-intraocular-pressure-in-different-body-positions
#9
Christina Lindén, Sara Qvarlander, Gauti Jóhannesson, Elias Johansson, Fanny Östlund, Jan Malm, Anders Eklund
PURPOSE: To test the hypothesis that normal-tension glaucoma (NTG) is caused by an increased pressure difference across the lamina cribrosa (LC) related to a low intracranial pressure (ICP). DESIGN: Prospective case-control study. PARTICIPANTS: Thirteen NTG patients (9 women; median 71 [range: 56-83] years) were recruited for investigation with the same protocol as 11 healthy volunteers (8 women; 47 [30-59] years). A larger control group (n = 51; 30 women; 68 [30-81] years) was used only for ICP comparison in supine position...
March 2018: Ophthalmology
https://www.readbyqxmd.com/read/28929290/management-of-blood-pressure-in-patients-with-glaucoma
#10
REVIEW
Russell M Levine, Alina Yang, Venkatesh Brahma, James F Martone
PURPOSE OF REVIEW: Ocular perfusion pressure (OPP) is defined as the difference between BP and intraocular pressure (IOP). With low BP comes low OPP and resultant ischemic damage to the optic nerve, leading to glaucoma progression. The purpose of this article is to review the literature on BP as it relates to glaucoma and to create a forum of discussion between ophthalmologists and internal medicine specialists. RECENT FINDINGS: Both high and low BP has been linked glaucoma...
September 19, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28875349/variations-in-optic-nerve-head-morphology-by-intraocular-pressure-in-open-angle-glaucoma
#11
COMPARATIVE STUDY
Aaron Wong, Kaliopy Matheos, Zak Prime, Helen V Danesh-Meyer
PURPOSE: To compare optic disc topography in eyes in three intraocular pressure (IOP) groups of <15 mmHg, 15-20 mmHg, and ≥21 mmHg using spectral domain optical coherence tomography (SD-OCT) and confocal scanning laser ophthalmoscopy, adjusting for the degree of damage, as measured by retinal nerve fiber layer (RNFL) thickness and average visual field loss. METHODS: A total of 184 eyes of 112 patients with primary open-angle glaucoma were recruited into groups based on baseline untreated intraocular pressure (IOP) of <15 mmHg (normal-tension glaucoma [NTG], very low), 15-20 mmHg (NTG, medium), or ≥21 mmHg (high-tension glaucoma [HTG])...
November 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28834385/long-term-results-of-deep-sclerectomy-in-normal-tension-glaucoma
#12
Mika Harju, Sakari Suominen, Pasi Allinen, Eija Vesti
PURPOSE: To study the long-term outcome of deep sclerectomy with and without mitomycin-C (MMC) in patients with normal-tension glaucoma (NTG). METHODS: We prospectively analysed consecutive patients randomized to surgery performed either with (MMC group) or without (non-MMC) MMC. Surgery was considered totally successful if, after surgery, the preoperative intra-ocular pressure (IOP) level was reduced by 25% without medication, and a qualified success if medication was required to achieve the same limits...
March 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28774517/normal-tension-glaucoma-management-a-survey-of-contemporary-practice
#13
MULTICENTER STUDY
Richard J Symes, Frederick S Mikelberg
OBJECTIVE: The aim of this study was to investigate contemporary practice patterns with respect to normal tension glaucoma (NTG) management and to determine whether the 2 largest NTG trials have influenced ophthalmologists' clinical practice. METHODS: A survey questionnaire was sent to ophthalmologists via the American Glaucoma Society, the Canadian Glaucoma Society, and the Canadian Ophthalmological Society. The questionnaire was designed to investigate ophthalmologists' usual practice with respect to NTG and the extent to which practice has been influenced by the Collaborative Normal Tension Glaucoma Study (CNTGS) and the Low pressure Glaucoma Treatment Study (LoGTS)...
August 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28725291/relationship-between-normal-tension-glaucoma-and-flammer-syndrome
#14
Katarzyna Konieczka, Hyuk Jin Choi, Simone Koch, Franz Fankhauser, Andreas Schoetzau, Dong Myung Kim
BACKGROUND: Besides intraocular pressure, vascular factors play a role in the pathogenesis of glaucomatous optic neuropathy. One of these potential vascular factors is Flammer syndrome. The purpose of the present study was to determine in a Korean population whether signs and symptoms of Flammer syndrome occur more often in normal tension glaucoma patients than in control subjects. METHODS: Two hundred forty-six normal tension glaucoma patients and 1116 control subjects responded to a multiple-choice questionnaire asking about 15 signs and symptoms of Flammer syndrome...
June 2017: EPMA Journal
https://www.readbyqxmd.com/read/28725290/the-discovery-of-the-flammer-syndrome-a-historical-and-personal-perspective
#15
REVIEW
Josef Flammer, Katarzyna Konieczka
This review describes the clinical and basic research that led to the description of Flammer syndrome. It is narrated from a personal perspective. This research was initiated by the observation of an increased long-term fluctuation of visual fields in a subgroup of glaucoma patients. As these patients had strikingly cold hands, peripheral blood flow was tested with a capillary microscopy, and vasospastic syndrome (VS) was diagnosed. Further studies on these patients revealed frequently weakened autoregulation of ocular blood flow and increased flow resistivity in retroocular vessels...
June 2017: EPMA Journal
https://www.readbyqxmd.com/read/28724826/bilateral-normal-tension-glaucoma-can-this-be-nutritional
#16
Sirisha Senthil, Kiranmaye Turaga
Normal tension glaucoma (NTG) also known as low tension glaucoma, presents with optic nerve head and visual field damage in the absence of high intraocular pressure (<21 mmHg). There are several patients of NTG seen in our clinics who have repeatable visual field defects, which may or may not correlate with the disc appearance, but are labeled as glaucoma. Ruling out ischemic, nutritional, and other causes of one-time damage are important before diagnosing an NTG. We report 3 such cases that were misdiagnosed and referred as NTG...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28571810/predictive-role-of-neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-in-normal-tension-glaucoma
#17
Kursat Atalay, Havva Kaldirim Erdogan, Ahmet Kirgiz, Senay Asik Nacaroglu
As a type of primary open-angle glaucoma, normal-tension glaucoma (NTG) is a health problem that manifests itself with low intraocular pressure (IOP) levels and preserves its importance for public health care. In population-based screenings, which take the IOP levels of 21mmHg as a cut-off for the diagnosis of glaucoma, the diagnosis is usually delayed, and the treatment is started in an advanced stage by the referred ophthalmologists. NTG is associated with some autoimmune conditions and systemic diseases, such as paraproteinemia, nocturnal hypotension, and migraine...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28315568/diurnal-blood-pressure-parameters-in-normal-tension-glaucoma-primary-open-angle-glaucoma-and-healthy-subjects
#18
Tolga Kocatürk, Çağdaş Akgüllü, Gökhan E Evliçoğlu, İmran K Ömürlü, Harun Çakmak, Ufuk Eryılmaz, Volkan Dayanır
OBJECTIVE: The pathophysiology of glaucoma is still undisclosed. Cardiovascular hemodynamic changes are hypothesized to contribute to glaucoma. This study aimed to determine the differences in the diurnal blood pressure (BP) of patients with normal tension glaucoma (NTG), primary open angle glaucoma (POAG), and controls without glaucoma. METHODS: A total of 129 patients were included in this study. The day-night average systolic and diastolic BPs, the day-night average pulse pressures (PPs), the day-night average heart rates, and the percentage of BP decline at night were obtained from the Holter devices and compared...
July 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28285308/clinical-features-of-japanese-patients-with-central-retinal-vein-occlusion-complicated-by-normal-tension-glaucoma-a-retrospective-study
#19
Teruyo Kida, Masanori Fukumoto, Takaki Sato, Hidehiro Oku, Tsunehiko Ikeda
PURPOSE: The association of central retinal vein occlusion (CRVO) with primary open-angle glaucoma (POAG) or ocular hypertension has been reported, and lowering intraocular pressure (IOP) helps to improve the retinal circulation in eyes with CRVO. However, the clinical features of CRVOs with normal-tension glaucoma (NTG) are not well known. Therefore, we investigated Japanese CRVO patients with NTG. METHODS: We retrospectively investigated 234 CRVO patients over 5 years, with follow-ups of more than 12 months, and evaluated the prevalence of glaucoma...
2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28139518/corneal-biomechanical-parameters-and-asymmetric-visual-field-damage-in-patients-with-untreated-normal-tension-glaucoma
#20
Bai-Bing Li, Yu Cai, Ying-Zi Pan, Mei Li, Rong-Hua Qiao, Yuan Fang, Tian Tian
BACKGROUND: High intraocular pressure (IOP) and low central corneal thickness (CCT) are important validated risk factors for glaucoma, and some studies also have suggested that eyes with more deformable corneas may be in higher risk of the development and worsening of glaucoma. In the present study, we aimed to evaluate the association between corneal biomechanical parameters and asymmetric visual field (VF) damage using a Corvis-ST device in patients with untreated normal tension glaucoma (NTG)...
February 5, 2017: Chinese Medical Journal
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