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classification pancreatitis

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https://www.readbyqxmd.com/read/29774182/spleen-and-splenic-vascular-involvement-in-acute-pancreatitis-an-mri-study
#1
Chao-Lian Xie, Mao Zhang, Yong Chen, Ran Hu, Meng-Yue Tang, Tian-Wu Chen, Hua-Dan Xue, Zheng-Yu Jin, Xiao-Ming Zhang
Background: To investigate the spleen and splenic vascular involvement in acute pancreatitis (AP) and their correlations with the severity of AP using magnetic resonance imaging (MRI). Methods: MRI of 239 patients with AP was retrospectively reviewed to assess splenic and splenic vascular complications, and the severity of AP. The severity of AP was graded by the MRI severity index (MRSI) and the New Revised Classification of AP 2012. The intravoxel incoherent motion (IVIM) parameters (D, D*, and f) of spleen were measured...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29771769/systemic-chemotherapy-for-advanced-rare-pancreatic-histotype-tumors-a-retrospective-multicenter-analysis
#2
Oronzo Brunetti, Giuseppe Aprile, Paolo Marchetti, Enrico Vasile, Andrea Casadei Gardini, Mario Scartozzi, Sandro Barni, Sara Delfanti, Fernando De Vita, Francesco Di Costanzo, Michele Milella, Chiara Alessandra Cella, Rossana Berardi, Ivana Cataldo, Aldo Scarpa, Debora Basile, Federica Mazzuca, Giusi Graziano, Antonella Argentiero, Daniele Santini, Michele Reni, Stefano Cascinu, Nicola Silvestris
OBJECTIVES: Two issues were put forth by clinicians in the management of the advanced stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes with peculiar clinical and pathological features: Do chemotherapy regimens recommended in pancreatic ductal adenocarcinoma patients have a clinical activity in rare pancreatic tumors? Or should other chemotherapy combinations be considered in this subset of patients? METHODS: We conducted a multicenter retrospective study that collected data from 2005 to 2016 at 14 Italian cancer centers with the aim to evaluate tumor response and time to progression for first- and second-line and overall survival...
May 15, 2018: Pancreas
https://www.readbyqxmd.com/read/29771764/intestinal-fatty-acid-binding-protein-as-a-marker-of-necrosis-and-severity-in-acute-pancreatitis
#3
Juozas Kupčinskas, Rolandas Gedgaudas, Hannes Hartman, Tomi Sippola, Outi Lindström, Colin Johnson, Sara Regnér
OBJECTIVES: The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). METHODS: In a prospective multicenter cohort study plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. RESULTS: Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients...
May 17, 2018: Pancreas
https://www.readbyqxmd.com/read/29760809/the-latest-exploration-of-staging-and-prognostic-classification-for-pancreatic-neuroendocrine-tumors-a-large-population-based-study
#4
Shanshan Gao, Ning Pu, Lingxiao Liu, Changyu Li, Xuefeng Xu, Xiaolin Wang, Wenhui Lou
Background: A modified European Neuroendocrine Tumor Society (mENETS) staging system has been confirmed to be more suitable for pancreatic neuroendocrine tumors (pNETs) when compared to the American Joint Committee on Cancer (AJCC) or the European Neuroendocrine Tumor Society (ENETS) systems in the last few years. However, the importance of N stage has been recently published with several significant updates. Methods: SEER registry (n = 2,209) was used to evaluate the application of the AJCC 7th staging system, ENETS staging system, mENETS staging system and reformed ENETS (rENETS) staging system in this study...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29752276/classification-of-pancreatic-cancer-ready-for-practical-application
#5
Danny N Khalil, Eileen M O'Reilly
There is great interest in an ability to categorize pancreas cancer and understand and classify the significant heterogeneity that exists in this disease. Such classifications based on morphologic, genetic, and immunologic features are emerging and the application of this information to provide both prognostic and predictive information is highly desired.
May 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29745561/-image-segmentation-and-classification-of-cytological-cells-based-on-multi-features-clustering-and-chain-splitting-model
#6
Pin Wang, Qianqian Liu, Lirui Wang, Yongming Li, Shujun Liu, Fang Yan
The diagnosis of pancreatic cancer is very important. The main method of diagnosis is based on pathological analysis of microscopic image of Pap smear slide. The accurate segmentation and classification of images are two important phases of the analysis. In this paper, we proposed a new automatic segmentation and classification method for microscopic images of pancreas. For the segmentation phase, firstly multi-features Mean-shift clustering algorithm (MFMS) was applied to localize regions of nuclei. Then, chain splitting model (CSM) containing flexible mathematical morphology and curvature scale space corner detection method was applied to split overlapped cells for better accuracy and robustness...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29735554/mirna-profiling-of-magnetic-nanopore-isolated-extracellular-vesicles-for-the-diagnosis-of-pancreatic-cancer
#7
Jina Ko, Neha Bhagwat, Taylor Black, Stephanie S Yee, Young-Ji Na, Stephen A Fisher, Junhyong Kim, Erica L Carpenter, Ben Z Stanger, David Issadore
Improved diagnostics for pancreatic ductal adenocarcinoma (PDAC) to detect the disease at earlier, curative stages and to guide treatments is crucial to progress against this disease. The development of a liquid biopsy for PDAC has proven challenging due to the sparsity and variable phenotypic expression of circulating biomarkers. Here we report methods we developed for isolating specific subsets of extracellular vesicles (EV) from plasma using a novel magnetic nanopore capture technique. In addition, we present a workflow for identifying EV miRNA biomarkers using RNA sequencing and machine-learning algorithms, which we used in combination to classify distinct cancer states...
May 7, 2018: Cancer Research
https://www.readbyqxmd.com/read/29722271/endoscopic-ultrasound-eus-guided-fine-needle-biopsy-fnb-with-the-procore%C3%A2-needle-provides-inadequate-material-for-the-histological-diagnosis-of-early-chronic-pancreatitis
#8
Julio Iglesias García, José Lariño-Noia, Ihab Abdulkader Nallib, Björn Lindkvist, J Enrique Domínguez-Muñoz
BACKGROUND: diagnosis of early chronic pancreatitis (CP) is hampered due to the low accuracy of current imaging techniques and the absence of methods for histological confirmation. We aimed to evaluate the efficacy of endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) for the histological diagnosis of early CP. METHODS: a prospective, cross-sectional, single-center study was designed. Consecutive patients referred for EUS with a clinical suspicion of CP were evaluated for inclusion into the study...
May 3, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29720389/access-to-radical-resections-of-pancreatic-cancer-is-region-dependent-despite-the-public-healthcare-system-in-finland
#9
Reea Ahola, Heini Hölsä, Samuli Kiskola, Pirkka Ojala, Aino Pirttilä, Juhani Sand, Johanna Laukkarinen
BACKGROUND: Surgical resection is the best treatment option to improve the prognosis of pancreatic cancer (PC). Our aim was to analyse whether PC treatment strategies show regional variation in Finland, a country with a nationwide public healthcare system. METHODS: All patients diagnosed with PC in 2003 and 2008 were identified from the Finnish Cancer Registry. The data regarding tumour, treatment, demographics and timespans to treatment were recorded from the patient archives...
May 2, 2018: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29717373/transpapillary-endopancreatic-surgery-decompression-of-duct-system-and-comparison-of-greenlight-laser-with-monopolar-electrosurgical-device-in-ex-vivo-and-in-vivo-animal-models
#10
Philip C Müller, Daniel C Steinemann, Lukas Chinczewski, Gencay Hatiboglu, Felix Nickel, Kaspar Z'graggen, Beat P Müller-Stich
BACKGROUND: Endopancreatic surgery (EPS) is an experimental minimally invasive technique for resection of pancreatic tissue from inside the pancreatic duct, accessed via the duodenum and papilla. It is proposed as an alternative to duodenum-preserving pancreatic head resection in benign diseases such as chronic pancreatitis (CP). This study evaluated the use of EPS for resection of pancreatic duct stenoses. Moreover, greenlight laser (GLL) and monopolar electrosurgical device (MES) were compared as resection tools for EPS...
May 1, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29696066/metastatic-neuroendocrine-pancreatic-tumor-case-report
#11
E C Radu, A I Saizu, R R Grigorescu, A E Croitoru, C Gheorghe
Rationale. Pancreatic neuroendocrine tumors (NETs) are rare neoplasms that develop from the endocrine tissues of the pancreas. They have a better overall prognosis than pancreatic adenocarcinoma. However, all commonly used classification systems reflect a separation between more indolent, well-differentiated tumors and far more aggressive poorly differentiated types that behave clinically more like small-cell carcinoma of the lung. Objective. To present the case of a 62-year-old man with an aggressive pancreatic NET, with liver, splenic and bone metastases who underwent multidisciplinary treatment including several lines of chemotherapy, somatostatin analogs and radiotherapy...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29690869/concurrent-presentation-of-an-intraductal-tubulopapillary-neoplasm-and-intraductal-papillary-mucinous-neoplasm-in-the-branch-duct-of-the-pancreas-with-a-superior-mesenteric-artery-aneurysm-a-case-report
#12
Kenta Inomata, Minoru Kitago, Hideaki Obara, Yoko Fujii-Nishimura, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Kentaro Matsubara, Go Oshima, Yasuhito Sekimoto, Masazumi Inoue, Osamu Itano, Michiie Sakamoto, Yuko Kitagawa
BACKGROUND: Since the concept of intraductal tubulopapillary neoplasm (ITPN) was introduced in the current World Health Organization classification of tumors, the number of reports of ITPN occurrence has increased gradually. However, ITPN is usually located in the main pancreatic duct, with few reports of a branch duct ITPN. As a result, imaging protocols for the diagnosis of a branch duct ITPN have not been established. CASE PRESENTATION: We report a case of a concurrent presentation of a branch duct ITPN and intraductal papillary mucinous neoplasm (IPMN) in the head of the pancreas, with a superior mesenteric artery (SMA) aneurysm...
April 24, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29672416/determinants-of-severity-in-acute-pancreatitis-a-nation-wide-multicenter-prospective-cohort-study
#13
Hanna Sternby, Federico Bolado, Héctor J Canaval-Zuleta, Carlos Marra-López, Ana I Hernando-Alonso, Adolfo Del-Val-Antoñana, Guillermo García-Rayado, Robin Rivera-Irigoin, Francisco J Grau-García, Lluís Oms, Judith Millastre-Bocos, Isabel Pascual-Moreno, David Martínez-Ares, Juan A Rodríguez-Oballe, Antonio López-Serrano, María L Ruiz-Rebollo, Alejandro Viejo-Almanzor, Belén González-de-la-Higuera, Aitor Orive-Calzada, Ignacio Gómez-Anta, José Pamies-Guilabert, Fátima Fernández-Gutiérrez-Del-Álamo, Isabel Iranzo-González-Cruz, Mónica E Pérez-Muñante, María D Esteba, Ana Pardillos-Tomé, Pedro Zapater, Enrique de-Madaria
OBJECTIVE: The aim of this study was to compare and validate the different classifications of severity in acute pancreatitis (AP) and to investigate which characteristics of the disease are associated with worse outcomes. SUMMARY OF BACKGROUND DATA: AP is a heterogeneous disease, ranging from uneventful cases to patients with considerable morbidity and high mortality rates. Severity classifications based on legitimate determinants of severity are important to correctly describe the course of disease...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29667417/review-of-duodenal-perforations-after-endoscopic-retrograde-cholangiopancreatography-in-hospital-puerta-de-hierro-from-1999-to-2014
#14
Elena Jiménez Cubedo, Javier López Monclús, José Luis Lucena de la Poza, Natalia González Alcolea, Pablo Calvo Espino, Arturo García Pavia, Victor Sánchez Turrión
INTRODUCTION: endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard in biliary and pancreatic pathology. Although the procedure has a significant morbidity and mortality rate. Algorithms are needed for the management and treatment of the associated complications. OBJECTIVE: to review the post-ERCP perforations treated in the Department of General Surgery of the Hospital Puerta de Hierro from 1999 to 2014. The results were evaluated according to the types of perforation and treatment...
April 18, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29661773/integrated-genomic-and-immunophenotypic-classification-of-pancreatic-cancer-reveals-three-distinct-subtypes-with-prognostic-predictive-significance
#15
Martin Wartenberg, Silvia Cibin, Inti Zlobec, Erik Vassella, Serenella M M Eppenberger-Castori, Luigi Terracciano, Micha Eichmann, Mathias Worni, Beat Gloor, Aurel Perren, Eva Karamitopoulou
PURPOSE: Current clinical classification of pancreatic ductal adenocarcinoma (PDAC) is unable to predict prognosis or response to chemo- or immunotherapy and does not take into account the host reaction to PDAC-cells. Our aim is to classify PDAC according to host- and tumor-related factors into clinically/biologically relevant subtypes by integrating molecular and microenvironmental findings. EXPERIMENTAL DESIGN: A well-characterized PDAC-cohort (n=110) underwent next-generation sequencing with a hotspot cancer panel, while Next-generation Tissue-Microarrays were immunostained for CD3, CD4, CD8, CD20, PD-L1, p63, hyaluronan-mediated motility receptor (RHAMM) and DNA mismatch-repair proteins...
April 16, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29660844/moray-micro-forceps-biopsy-improves-the-diagnosis-of-specific-pancreatic-cysts
#16
M Lisa Zhang, Ronald N Arpin, William R Brugge, David G Forcione, Omer Basar, Martha B Pitman
BACKGROUND: Making a specific diagnosis of pancreatic cysts preoperatively is difficult. The new disposable Moray micro forceps biopsy (MFB) device allows tissue sampling from the pancreatic cyst wall/septum and aims to improve diagnosis. This study compares the diagnostic performance of the MFB with the current conventional analysis of pancreatic cyst fluid (PCF). METHODS: A total of 48 patients sampled with MFB were identified. Cysts were classified as mucinous on PCF based on extracellular mucin/mucinous epithelium, carcinoembryonic antigen (CEA) levels ≥192 ng/mL, or KRAS/GNAS mutation...
April 16, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29660323/nationwide-trends-in-acute-and-chronic-pancreatitis-among-privately-insured-children-and-non-elderly-adults-in-the-united-states-2007-2014
#17
Zachary M Sellers, Donna MacIsaac, Helen Yu, Melody Dehghan, Ke-You Zhang, Rachel Bensen, Jessie J Wong, Cindy Kin, K T Park
BACKGROUND & AIMS: Epidemiologic analyses of acute and chronic pancreatitis (AP and CP) provide insight into causes and strategies for prevention, and affect allocation of resources to its study and treatment. We sought to determine current and accurate incidences of AP and CP, along with the prevalence of CP, in children and adults in the United States. METHODS: We collected data from the Truven MarketScan Research Databases of commercial inpatient and outpatient insurance claims in the United States from 2007 through 2014 (patients 0-64 years old)...
April 13, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29658583/intraductal-papillary-mucinous-neoplasms-of-the-pancreas-clinical-association-with-kras
#18
Xiao Yan Chang, Yan Wu, Yuan Li, Jing Wang, Jie Chen
Intraductal papillary mucinous neoplasms of the pancreas (IPMN) are among the most important precancerous lesions in the pancreas. V‑Ki‑ras 2 Kirsten rat sarcoma viral oncogene homolog (KRAS) is one of the most important genes involved in pancreatic neoplasms, and exhibits a high mutation rate in pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasia. The present study aimed to further elucidate the associations among IPMN subtypes (gastric, intestinal, pancreatobiliary and oncocytic), pathological classifications [low‑grade, intermediate‑grade, and high‑grade IPMN, and associated minimally invasive carcinoma (invasive depth ≤0...
April 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29657614/acute-pancreatitis-in-children
#19
Urszula Grzybowska-Chlebowczyk, Martyna Jasielska, Anna Flak-Wancerz, Sabina Więcek, Katarzyna Gruszczyńska, Wojciech Chlebowczyk, Halina Woś
Introduction: The acute pancreatitis is a rare disease, but it has started to be diagnosed more often in children. Aim: The aim of the study was single-centre, retrospective analysis of the incidence, aetiology, and clinical course of acute pancreatitis in children. Material and methods: We analysed the medical records of patients with acute pancreatitis hospitalised in the Gastroenterology Unit of the Paediatrics Department, Medical University of Silesia from Jan 2004 to Dec 2013...
2018: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/29656597/splenic-artery-as-a-simple-landmark-indicating-difficulty-during-laparoscopic-distal-pancreatectomy
#20
Yoshiya Ishikawa, Daisuke Ban, Shuichi Watanabe, Keiichi Akahoshi, Hiroaki Ono, Yusuke Mitsunori, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe
INTRODUCTION: The use of laparoscopic distal pancreatectomy (LDP) is increasing worldwide. It is important for surgeons to predict preoperatively the difficulty and risks of a surgery. However, very few reports have evaluated the impact of patient or tumor factors on the difficulty of LDP. We aimed to determine the predictors of technical difficulties when performing LDP. METHODS: This study included 34 patients who underwent LDP. Patient information was obtained retrospectively and included age, gender, BMI, primary disease, previous abdominal surgery, previous pancreatitis, tumor size, tumor proximity to the splenic arterial origin, type of splenic artery (SpA), operative time, blood loss, postoperative pancreatic fistula, and length of hospital stay...
April 15, 2018: Asian Journal of Endoscopic Surgery
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