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https://www.readbyqxmd.com/read/28437585/chronic-intestinal-electrical-stimulation-improves-glucose-intolerance-and-insulin-resistance-in-diet-induced-obesity-rats
#1
Shiying Li, Weijian Zhu, Sujuan Zhang, Jiande Dz Chen
OBJECTIVE: Obesity is a contributing factor to insulin resistance and type 2 diabetes. The aim of this study was to study the therapeutic potential of intestinal electrical stimulation (IES) for obesity and associated glucose intolerance and insulin resistance in diet-induced obesity (DIO) rats. METHODS: DIO rats were divided into two groups to receive sham or IES for 8 weeks. Oral glucose tolerance and insulin tolerance tests were performed. Gastric emptying and small bowel transit tests were performed...
April 24, 2017: Obesity
https://www.readbyqxmd.com/read/28437574/dietary-lactalbumin-and-lactoferrin-interact-with-inulin-to-modulate-energy-balance-in-obese-rats
#2
Arashdeep Singh, Rizaldy C Zapata, Adel Pezeshki, Prasanth K Chelikani
OBJECTIVE: To determine whether diets enriched with the whey protein components lactalbumin and lactoferrin interact additively with inulin to improve energy balance by decreasing food intake and body weight (BW). METHODS: In four experiments, diet-induced obese rats were randomized to diets containing either lactalbumin or lactoferrin at low (20% kcal) or high (40% kcal) doses, and inulin at low (7.5% w/w) or high (15% w/w) doses, alone or in combination. Energy intake (EI), energy expenditure (EE), respiratory quotient (RQ), BW, body composition, plasma insulin, and leptin concentrations were measured...
April 24, 2017: Obesity
https://www.readbyqxmd.com/read/28437263/a-randomised-trial-to-evaluate-preoperative-oral-carbohydrate-administration-on-insulin-resistance-in-off-pump-coronary-artery-bypass-patients
#3
Bora Lee, Sarah Soh, Jae-Kwang Shim, Ha Y Kim, Hyelin Lee, Young-Lan Kwak
BACKGROUND: In fasting cardiac surgery patients, preoperative carbohydrate (CHO) drink intake attenuated insulin resistance and improved cardiac metabolism, although its beneficial effects were not evident after cardiac surgery possibly due to cardiopulmonary bypass-related extreme systemic inflammation. OBJECTIVE: We aimed to evaluate whether preoperative CHO intake affected insulin resistance and free-fatty acid (FFA) concentrations in off-pump coronary revascularisation...
April 21, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28437200/effects-of-dietary-macronutrient-composition-on-fndc5-and-irisin-in-mice-skeletal-muscle
#4
Simone Moreira de Macêdo, Deborah de Farias Lelis, Keila Lopes Mendes, Carlos Alberto de Carvalho Fraga, Igor V Brandi, Jonh David Feltenberger, Lucyana Conceição Farias, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Sérgio Henrique de Sousa Santos
BACKGROUND: Fibronectin type III domain containing 5 (FNDC5) and its protein product Irisin are therapeutic targets for obesity-associated disorders. Irisin plays an important role in energy regulation, inducing browning of white adipocytes, and improving obesity. We aimed to investigate the association between muscle Irisin expression and dietary quality. METHODS: Twenty-eight female mice were divided into four groups and fed the following experimental diets for 60 days: standard diet (SD), high-carbohydrate diet (HCD), high-fat diet (HFD), and high-protein diet (HPD)...
February 23, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28436762/use-of-dietary-vitamin-supplements-and-risk-of-thyroid-cancer-a-population-based-case-control-study-in-connecticut
#5
Christopher Kim, Huang Huang, Nan Zhao, Catherine C Lerro, Min Dai, Yingtai Chen, Ni Li, Shuangge Ma, Robert Udelsman, Yawei Zhang
Certain dietary supplements have been reported to increase the risk of some cancers. Over half of the US population regularly uses dietary supplements. Thyroid cancer incidence has increased over the past several decades. However, few studies have investigated the association between dietary supplements and thyroid cancer. Thus, it is essential to clarify any association between dietary supplements and risk of thyroid cancer. MATERIALS AND METHODS: A population-based case-control study in Connecticut was conducted during 2010-2011 among 462 histologically confi rmed incident thyroid cancer cases and 498 population-based controls...
April 24, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28436747/difructose-anhydride-iii-decreases-body-fat-as-a-low-energy-substitute-or-by-decreasing-energy-intake-in-non-ovariectomized-and-ovariectomized-female-rats
#6
Mina Fujitani, Taro Kishida, Emi Shimizu, Junji Ishikawa
We evaluated the effects of difructose anhydride III (DFAIII) on body weights of ovariectomized rats, which are a good model for obesity by estrogen deficiency-induced overeating. Female rats (10 weeks old) were subjected to ovariectomy or sham operation and then fed with or without a diet containing 3% or 6% DFAIII for 33 days or pair-fed control diet during the same period. Rats fed DFAIII showed significantly decreased food intake, energy intake, body weight gain, body energy accumulation, and fat tissue weight than control group, regardless of ovariectomy...
April 24, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28435032/clinical-efficacy-of-1-year-intensive-systematic-dietary-manipulation-as-complementary-and-alternative-medicine-therapies-on-female-interstitial-cystitis-bladder-pain-syndrome-patients
#7
Hitoshi Oh-Oka
OBJECTIVE: To evaluate the clinical efficacy of intensive systematic dietary manipulation (ISDM) for female patients with interstitial cystitis (IC)/bladder pain syndrome (BPS) in stable condition who were followed in our hospital. MATERIALS AND METHODS: In cooperation with the nutrition control team, we created a basic IC/BPS diet menu for 1 month. Data regarding daily food intake and food-related symptoms were collected by detailed interview of each patient, we set meal menu to control IC/BPS symptoms and advised the patients to reduce the intake of specific food items to the maximum possible extent...
April 20, 2017: Urology
https://www.readbyqxmd.com/read/28433993/determinants-of-perceived-stress-in-individuals-with-obesity-exploring-the-relationship-of-potentially-obesity-related-factors-and-perceived-stress
#8
Florian Junne, Katrin Ziser, Katrin Elisabeth Giel, Kathrin Schag, Eva Skoda, Isabelle Mack, Andreas Niess, Stephan Zipfel, Martin Teufel
OBJECTIVE: Associations of specific types of stress with increased food intake and subsequent weight gain have been demonstrated in animal models as well as in experimental and epidemiological studies on humans. This study explores the research question of to what extent potentially obesity-related factors determine perceived stress in individuals with obesity. METHODS: N = 547 individuals with obesity participated in a cross-sectional study assessing perceived stress as the outcome variable and potential determinants of stress related to obesity...
April 22, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28433470/daily-supplementation-of-dietary-protein-improves-the-metabolic-effects-of-glp-1-based-pharmacotherapy-in-lean-and-obese-rats
#9
Elizabeth G Mietlicki-Baase, Kieran Koch-Laskowski, Lauren E McGrath, Joanna Krawczyk, Tram Pham, Rinzin Lhamo, David J Reiner, Matthew R Hayes
Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from intestinal L-cells in response to food entering into the gastrointestinal tract. GLP-1-based pharmaceuticals improve blood glucose regulation and reduce feeding. Specific macronutrients, when ingested, may trigger GLP-1 secretion and enhance the effects of systemic sitagliptin, a pharmacological inhibitor of DPP-IV (an enzyme that rapidly degrades GLP-1). In particular, macronutrient constituents found in dairy foods may act as potent secretagogues for GLP-1, and acute preclinical trials show that ingestion of dairy protein may represent a promising adjunct behavioral therapy in combination with sitagliptin...
April 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28432759/anesthetic-and-postanesthetic-effects-of-alfaxalone-butorphanol-compared-with-dexmedetomidine-ketamine-in-chinchillas-chinchilla-lanigera
#10
Lily Parkinson, Christoph Mans
Effective and safe anesthetic protocols are required for a variety of surgical and diagnostic procedures in chinchillas.Alfaxalone, a new anesthetic agent in the United States, can be administered intramuscularly and subcutaneously and is therefore potentially useful as an anesthetic induction agent in chinchillas. This study compared the anesthetic efficacy andpostanesthetic effects on food intake and fecal output of a combination of intramuscular alfaxalone (5 mg/kg) and butorphanol(0.5 mg/kg; AB anesthesia) with a combination of dexmedetomidine (0...
April 21, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28432400/-the-intestinal-microbiome-and-metabolic-diseases-from-obesity-to-diabetes-and-nonalcoholic-steatohepatitis
#11
S C Bischoff
BACKGROUND: The intestinal microbiome consists of about 10 million genes, many of which encode digestive enzymes. This explains why animal and human experiments revealed that the intestinal microbiome adapts to food intake and optimizes energy harvest from food. This function is considered beneficial in states of lack of food, but following overnutrition, it might support the development of obesity. OBJECTIVES: The relevance of the intestinal microbiome for the pathogenesis of obesity and associated metabolic diseases such as fatty liver disease and type 2 diabetes mellitus and for the clinical management of such diseases shall be discussed...
April 21, 2017: Der Internist
https://www.readbyqxmd.com/read/28432007/caloric-compensation-in-preschool-children-relationships-with-body-mass-and-differences-by-food-category
#12
S Carnell, L Benson, E L Gibson, L A Mais, S Warkentin
Maintaining a healthy weight may involve compensating for previously consumed calories at subsequent meals. To test whether heavier children demonstrated poorer caloric compensation across a range of conditions, and to explore whether compensation failure was the result of inadequate adjustment of overall intake or specific over-consumption of highly palatable, high energy-density 'junk' foods, we administered two compensation tests to a sample of 4-5 y olds. For Test A, preloads varied only in carbohydrate content and were organoleptically indistinguishable (200 ml orange-flavored beverage [0 kcal vs...
April 18, 2017: Appetite
https://www.readbyqxmd.com/read/28431979/past-exposure-to-fruit-and-vegetable-variety-moderates-the-link-between-fungiform-papillae-density-and-current-variety-of-fv-consumed-by-children
#13
Anna Fogel, Jackie Blissett
Higher fungiform papillae density (FPD) has been associated with lower taste sensitivity thresholds and greater perceived taste intensity along with consumption of fewer fruit and vegetables (FV). Children exposed to greater variety of FV tend to habitually consume more FV, however, it is unknown whether exposure effects are attenuated by individual differences in FPD or whether these effects vary according to sensory properties of FV. This study examined the links between children's FPD, current variety of FV consumed, and past experiences with variety of fruit and vegetables...
April 18, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28431449/peripheral-and-central-glucocorticoid-signaling-contributes-to-positive-energy-balance-in-rats
#14
Tássia Karin Borba, Lígia Cristina Monteiro Galindo, Kelli Nogueira Ferraz-Pereira, Raquel da Silva Aragão, Ana Elisa Toscano, Omar Guzmán-Quevedo, Raul Manhães-de-Castro
The obesity epidemic has been the target of several studies to understand its etiology. The pathophysiological processes that take to obesity generally relate to the rupture of energy balance. This imbalance can result from environmental and/or endogenous events. Among the endogenous events, the hypothalamic-pituitary-adrenal axis, which promotes stress response via glucocorticoid activity, is considered a modulator of energy balance. However, it remains controversial whether the increase in plasma levels of glucocorticoids results in a positive or negative energy balance...
April 21, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28431261/dietary-patterns-and-depression-risk-a-meta-analysis
#15
REVIEW
Ye Li, Mei-Rong Lv, Yan-Jin Wei, Ling Sun, Ji-Xiang Zhang, Huai-Guo Zhang, Bin Li
Although some studies have reported potential associations of dietary patterns with depression risk, a consistent perspective hasn't been estimated to date. Therefore, we conducted this meta-analysis to evaluate the relation between dietary patterns and the risk of depression. A literature research was conducted searching MEDLINE and EMBASE databases up to September 2016. In total, 21 studies from ten countries met the inclusion criteria and were included in the present meta-analysis. A dietary pattern characterized by a high intakes of fruit, vegetables, whole grain, fish, olive oil, low-fat dairy and antioxidants and low intakes of animal foods was apparently associated with a decreased risk of depression...
April 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28430907/food-intake-affects-sperm-egg-fusion-through-the-gip-psg17-axis-in-mice
#16
Tatsunori Shimizu, Takehiro Sato, Katsushi Tsukiyama, Hiroki Fujita, Shunsuke Kato, Manabu Hoizumi, Hiromitsu Shirasawa, Takuma Narita, Yukihiro Terada, Yutaka Seino, Yuichiro Yamada
In addition to overeating, starvation also reduces fecundity in mammals. However, little is known about the molecular mechanisms linking food intake to fertility, especially in males. Gastric inhibitory polypeptide (GIP), which is released from intestinal K-cells after meal ingestion, stimulates insulin secretion from pancreatic β-cells through the action of incretin and has several extra-pancreatic effects. Here, we identified GIP receptor (Gipr) expression in mouse spermatids. Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9-binding partner, was significantly decreased in GIP receptor-knockout (Gipr-/-) testes...
April 19, 2017: Endocrinology
https://www.readbyqxmd.com/read/28430398/impact-of-acid-reducing-agents-on-the-pharmacokinetics-of-palbociclib-a-weak-base-with-ph-dependent-solubility-with-different-food-intake-conditions
#17
Wan Sun, Karen J Klamerus, Lisa M Yuhas, Sylvester Pawlak, Anna Plotka, Melissa O'Gorman, Leonid Kirkovsky, Maha Kosa, Diane Wang
Palbociclib free base capsule is a weak base drug with highly pH-dependent solubility. In vitro and in vivo studies evaluated the impact of acid-reducing agents on exposure of palbociclib and determined whether the impact, if any, can be mitigated by food. A drug-drug interaction study (study 1) was conducted first under fasted conditions and showed that coadministration of multiple doses of the proton-pump inhibitor rabeprazole substantially reduced palbociclib mean area under the concentration-time curve from time 0 to infinity and maximum observed plasma concentration by 62% and 80%, respectively...
April 21, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28429924/dietary-choice-and-health-behaviors-in-eastern-chinese-women-a-descriptive-population-based-survey-and-review-of-public-health-data
#18
Feng Wang, Fei Wang, Lixiang Yu, Zhigang Yu
BACKGROUND AND OBJECTIVES: Urbanization in China has increased the prevalence of high-fat and low-fiber diets, and of adverse health behaviors associated with an increased risk of diet-related, non-communicable diseases (DR-NCDs) in eastern Chinese women. This study aimed to characterize the dietary intake and health behaviors in eastern Chinese women. METHODS AND STUDY DESIGN: Retrospective data of 122,058 women aged 25 to 70 who completed a multi-staged, stratified, cluster sampling epidemiological survey in eastern China in 2008, including self-report of diet and lifestyle information (sleep, physical activity, work, etc...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429922/effect-modification-of-green-tea-on-the-association-between-rice-intake-and-the-risk-of-diabetes-mellitus-a-prospective-study-in-japanese-men-and-women
#19
Akie Hirata, Keizo Ohnaka, Naotaka Tashiro, Zhenjie Wang, Michiko Kohno, Chikako Kiyohara, Suminori Kono, Ryoichi Takayanagi
BACKGROUND AND OBJECTIVES: Recent observational studies have suggested a positive association of white rice and protective associations of green tea and coffee with the risk of diabetes. However, none have examined the interaction between these dietary factors on the risk of diabetes. We prospectively investigated the effect modification of green tea and coffee on the association between rice and incident diabetes in elderly Japanese men and women. METHODS AND STUDY DESIGN: Among subjects who participated in the baseline survey (2004-2007), 11717 (91 %) subjects responded to the follow-up survey (2010-2012)...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28429921/relationship-between-dietary-patterns-and-brachial-ankle-pulse-wave-velocity-among-middle-aged-adults-in-japan
#20
Shota Moyama, Kazuhiro Minami, Mihiro Yano, Masumi Okumura, Susumu Hayashi, Hiroshi Takayama, Akira Yorimoto
BACKGROUND AND OBJECTIVES: Arterial stiffness is a leading cause of cardiovascular disease (CVD), and it is considered to be affected by dietary intake. However, few studies have examined the relationship between major dietary patterns and brachial-ankle pulse wave velocity (baPWV) among Japanese middle-aged subjects. We studied whether major dietary patterns were associated with baPWV in this population. METHODS AND STUDY DESIGN: Between 2009 and 2012, 70 Japanese middle-aged subjects (39 men and 31 women) with no history of stroke, coronary heart disease, or cancer were studied...
May 2017: Asia Pacific Journal of Clinical Nutrition
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