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https://www.readbyqxmd.com/read/28922036/location-and-modality-effects-in-online-dating-rich-modality-profile-and-location-based-information-cues-increase-social-presence-while-moderating-the-impact-of-uncertainty-reduction-strategy
#1
Soyoung Jung, Soojin Roh, Hyun Yang, Frank Biocca
This study investigates how different interface modality features of online dating sites, such as location awareness cues and modality of profiles, affect the sense of social presence of a prospective date. We also examined how various user behaviors aimed at reducing uncertainty about online interactions affect social presence perceptions and are affected by the user interface features. Male users felt a greater sense of social presence when exposed to both location and accessibility cues (geographical proximity) and a richer medium (video profiles)...
September 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28869355/black-pigment-gallstone-inspired-platinum-chelated-bilirubin-nanoparticles-for-combined-photoacoustic-imaging-and-photothermal-therapy-of-cancers
#2
Dong Lee, Jin Kim, Yonghyun Lee, Soyoung Lee, Wenjun Miao, Hyeon Kim, Jung-Joon Min, Sangyong Jon
Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, here we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ~100-nm-size nanoparticles...
September 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28825663/efficacy-of-repeated-botulinum-toxin-type-a-injections-for-spastic-equinus-in-children-with-cerebral-palsy-a-secondary-analysis-of-the-randomized-clinical-trial
#3
Bo Young Hong, Hyun Jung Chang, Sang-Jee Lee, Soyoung Lee, Joo Hyun Park, Jeong-Yi Kwon
Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, randomized, prospective phase III clinical trial of botulinum toxin A for the treatment of dynamic equinus in 144 children with cerebral palsy was performed to compare the efficacies of letibotulinumtoxin A and onabotulinumtoxin A...
August 21, 2017: Toxins
https://www.readbyqxmd.com/read/28820439/efficacy-and-safety-of-letibotulinum-toxin-a-for-the-treatment-of-dynamic-equinus-foot-deformity-in-children-with-cerebral-palsy-a-randomized-controlled-trial
#4
Hyun Jung Chang, Bo Young Hong, Sang-Jee Lee, Soyoung Lee, Joo Hyun Park, Jeong-Yi Kwon
The objective of this clinical trial was to compare the efficacy and safety of letibotulinum toxin A and onabotulinum toxin A for improving dynamic equinus foot deformity in children with cerebral palsy (CP). In total, 144 children with spastic CP who had dynamic equinus foot deformity were assigned randomly to the Botulax group (injection of letibotulinum toxin A) or the Botox group (injection of onabotulinum toxin A). The Physician's Rating Scale (PRS), ankle plantar flexor spasticity using the Modified Tardieu Scale, the Gross Motor Function Measure (GMFM)-88, and the GMFM-66 were completed before injection and at 6, 12, and 24 weeks after injection...
August 18, 2017: Toxins
https://www.readbyqxmd.com/read/28699786/inactivation-of-norovirus-by-lemongrass-essential-oil-using-a-norovirus-surrogate-system
#5
Ye Won Kim, Hyun Ju You, Soyoung Lee, Bomi Kim, Do Kyung Kim, Joo-Bong Choi, Ji-Ah Kim, Hee Jung Lee, In Sun Joo, Jeong Su Lee, Dong Hyun Kang, Giljae Lee, Gwang Pyo Ko, Sung-Joon Lee
This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay...
July 12, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28539949/screening-for-depressive-disorder-in-elderly-patients-with-chronic-physical-diseases-using-the-patient-health-questionnaire-9
#6
Seon-Cheol Park, Hwa-Young Lee, Dong-Woo Lee, Sang-Woo Hahn, Sang-Ho Park, Yeo Ju Kim, Jae Sung Choi, Ho-Sung Lee, Soyoung Irene Lee, Kyoung-Sae Na, Sung Won Jung, Se-Hoon Shim, Ki Won Kim, Jong-Woo Paik, Young-Joon Kwon
OBJECTIVE: We aimed to identify depressive symptom profiles that indicated the presence of depressive disorder and present optimal cut-off sub-scores for depressive symptom profiles for detecting depressive disorder in elderly subjects with chronic physical diseases including diabetes, chronic obstructive pulmonary disease/asthma, and coronary artery disease, using the Patient Health Questionnaire-9 (PHQ-9). METHODS: Two hundred and thirty-one elderly patients with chronic physical diseases were recruited consecutively from a university-affiliated general hospital in South Korea...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28480644/similarity-analysis-of-korean-medical-literature-and-its-association-with-efforts-to-improve-research-and-publication-ethics
#7
Soyoung Park, Seung Ho Yang, Eugene Jung, Yeon Mi Kim, Hyun Sung Baek, Young Mo Koo
In the present study, the frequency of research misconduct in Korean medical papers was analyzed using the similarity check software iThenticateĀ®. All Korean papers written in English that were published in 2009 and 2014 in KoreaMed Synapse were identified. In total, 23,848 papers were extracted. 4,050 Journal Articles of them were randomly selected for similarity analysis. The average Similarity Index of the 4,050 papers decreased over time, particularly in 2013: in 2009 and 2014, it was 10.15% and 5.62%, respectively...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28462887/an-acute-pancreatitis-due-to-a-pancreatic-epidermoid-cyst-contrast-endoscopic-ultrasonography
#8
Gun Jung Youn, Chang Nyol Paik, Soyoung Im, Ji-Han Jung
No abstract text is available yet for this article.
June 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28326113/factors-that-affect-the-adherence-to-adhd-medications-during-a-treatment-continuation-period-in-children-and-adolescents-a-nationwide-retrospective-cohort-study-using-korean-health-insurance-data-from-2007-to-2011
#9
Soo-Young Bhang, Young Sook Kwack, Yoo-Sook Joung, Soyoung Irene Lee, Bongseog Kim, Seok Han Sohn, Un-Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung-Yun Choi, In Hwan Oh, Yeon Jung Lee, Jun-Won Hwang
OBJECTIVE: Several factors, such as male gender, older age, type of insurance, comorbid conditions, and medication type, have been associated with attention-deficit/hyperactivity disorder (ADHD) medication adherence rates, but the results have been inconsistent. We analyzed data to answer several questions: 1) How old were patients who first refilled their treatment medications used primarily for ADHD, regardless of the medication type? 2) What socio-demographic factors are associated with medication adherence? 3) What medical conditions, such as medication type and comorbid diagnosis, influence adherence? METHODS: We analyzed National Health Insurance data, which comprised continuously enrolled Korean National Medical Insurance children (6-18 years) with at least 2 ADHD prescription claims (January 2008-December 2011)...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28261302/the-vitamin-d-analogue-paricalcitol-attenuates-hepatic-ischemia-reperfusion-injury-through-down-regulation-of-toll-like-receptor-4-signaling-in-rats
#10
Min Sung Kim, Soyoung Lee, Namhee Jung, Kiho Lee, Jinwoo Choi, Sang-Hoon Kim, Jinhyun Jun, Won-Mee Lee, Yeonsoo Chang, Donghee Kim
INTRODUCTION: Recent studies have revealed that vitamin D and its synthetic analogues have a protective effect on experimental ischemia/reperfusion (I/R) models in several organs, but little is known about its effect on the liver. The aim of this study was to evaluate the beneficial effects of vitamin D in a model of liver I/R in rats, focusing on Toll-like receptor (TLR) 4 signaling, which has been shown to be involved in I/R injury. MATERIAL AND METHODS: Twenty-four male Wistar rats were randomized into four groups: Saline + Sham, Saline + I/R, Paricalcitol + Sham, and Paricalcitol + I/R...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28132102/comparative-effectiveness-of-treatment-options-after-conventional-dmards-failure-in-rheumatoid-arthritis
#11
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Chan-Bum Choi, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Hyoun Ah Kim, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Shin-Seok Lee, Sung Won Lee, Yeon-Ah Lee, Seong-Su Nah, Chang-Hee Suh, Dae-Hyun Yoo, Bo Young Yoon, Sang Cheol Bae
OBJECTIVE: To compare the clinical effectiveness of two treatment strategies for active rheumatoid arthritis (RA) refractory to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs): starting TNF inhibitors (TNFIs) or changing csDMARDs. METHODS: We used two nationwide Korean RA registries for patient selection. TNFI users were selected from the BIOPSY, which is an inception cohort of RA patients starting biologic DMARDs. As a control group, we selected RA patients with moderate or high disease activity from the KORONA database whose treatment was changed to other csDMARDs...
June 2017: Rheumatology International
https://www.readbyqxmd.com/read/28064100/evaluating-the-effects-of-supplemental-rest-areas-on-freeway-crashes-caused-by-drowsy-driving
#12
Soyoung Jung, Shinhye Joo, Cheol Oh
To prevent crashes caused by drowsy driving, supplemental rest areas have been installed in the South Korean freeway system to allow road users to rest. These supplemental rest areas are very small-sized resting facilities located between the larger regular rest areas, which is a unique design. This study aimed to evaluate the effects of the supplemental rest areas on reducing crashes caused by drowsy driving. Between 2011 and 2012, supplemental rest areas were first installed in the Gyeongbu Freeway, which was selected as the study area for this study...
February 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#13
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
February 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27769686/mathematical-model-of-transmission-dynamics-and-optimal-control-strategies-for-2009-a-h1n1-influenza-in-the-republic-of-korea
#14
Soyoung Kim, Jonggul Lee, Eunok Jung
A mathematical model for the transmission dynamics of the 2009 A/H1N1 influenza epidemic in the Republic of Korea is developed. The simulation period is separated into three consecutive periods based on the government's intervention strategies: the nonpharmaceutical strategy is used during Period 1. The nonpharmaceutical and antiviral strategies are executed during Period 2 and the vaccine strategy is added during Period 3. During Period 1, we estimate the reduction in the transmission rate due to the government's intervention policies as a difference between the data-fitted and uncontrolled transmission rate that is derived from the basic reproductive number, R0, of the model without intervention...
January 7, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27618867/impact-of-early-diagnosis-on-functional-disability-in-rheumatoid-arthritis
#15
Dam Kim, Chan-Bum Choi, Jiyoung Lee, Soo-Kyung Cho, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Tae-Jong Kim, Eunmi Koh, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Sang-Heon Lee, Shin-Seok Lee, Sung Won Lee, Seung-Cheol Shim, Dae-Hyun Yoo, Bo Young Yoon, Yoon-Kyoung Sung, Sang-Cheol Bae
BACKGROUND/AIMS: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients. METHODS: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of ā‰¤ 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group. Demographic characteristics and outcomes were compared between early and delayed diagnosis groups...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27506573/eudesmane-type-sesquiterpenoids-from-salvia-plebeia-inhibit-il-6-induced-stat3-activation
#16
Hyun-Jae Jang, Hyun-Mee Oh, Joo Tae Hwang, Mi-Hwa Kim, Soyoung Lee, Kyungsook Jung, Young-Ho Kim, Seung Woong Lee, Mun-Chual Rho
Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1...
October 2016: Phytochemistry
https://www.readbyqxmd.com/read/27478341/differences-in-utilization-patterns-among-medications-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-36-month-retrospective-study-using-the-korean-health-insurance-review-and-assessment-claims-database
#17
Soo-Young Bhang, Jun-Won Hwang, Young-Sook Kwak, Yoo Sook Joung, Soyoung Lee, Bongseog Kim, Seok Han Sohn, Un Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung Yun Choi, In-Hwan Oh, Yeon Jung Lee
We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and adolescents with ADHD who were not given their newly prescribed medication in 360 days before the initial claim in 2010...
August 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27377134/an-amphiphilic-peptide-induces-apoptosis-through-the-mir29b-p53-pathway-in-cancer-cells
#18
Soyoung Kim, Jung Hyun Lee, Igojo Kang, Soonsil Hyun, Jaehoon Yu, Chanseok Shin
Peptides have been in the limelight, as therapeutic agents for cancer treatment through various applications due to their high target selectivity and exceptional ability to penetrate the cell membrane. Recent studies have revealed that synthesized peptides bind to hairpin structures of RNA that affect their activities such as changing the efficacy of microRNA maturation. MicroRNA-mediated p53 activation by the microRNA-29 (miR29) family is one of the most important regulatory pathways in cancer therapeutics...
2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27373668/sesquiterpenoids-from-the-rhizomes-of-curcuma-phaeocaulis-and-their-inhibitory-effects-on-lps-induced-tlr4-activation
#19
Hyun-Jae Jang, Jin-Han Kim, Hyun-Mee Oh, Min-Suk Kim, Jin Ha Jo, Kyungsook Jung, Soyoung Lee, Young-Ho Kim, Woo Song Lee, Seung Woong Lee, Mun-Chual Rho
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27317249/a-randomized-controlled-trial-of-an-educational-video-to-improve-quality-of-bowel-preparation-for-colonoscopy
#20
RANDOMIZED CONTROLLED TRIAL
Jin-Seok Park, Min Su Kim, HyungKil Kim, Shin Il Kim, Chun Ho Shin, Hyun Jung Lee, Won Seop Lee, Soyoung Moon
BACKGROUND: High-quality bowel preparation is necessary for colonoscopy. A few studies have been conducted to investigate improvement in bowel preparation quality through patient education. However, the effect of patient education on bowel preparation has not been well studied. METHODS: A randomized and prospective study was conducted. All patients received regular instruction for bowel preparation during a pre-colonoscopy visit. Those scheduled for colonoscopy were randomly assigned to view an educational video instruction (video group) on the day before the colonoscopy, or to a non-video (control) group...
June 17, 2016: BMC Gastroenterology
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