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https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#1
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
November 17, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27769686/mathematical-model-of-transmission-dynamics-and-optimal-control-strategies-for-2009-a-h1n1-influenza-in-the-republic-of-korea
#2
Soyoung Kim, Jonggul Lee, Eunok Jung
A mathematical model for the transmission dynamics of the 2009 A/H1N1 influenza epidemic in the Republic of Korea is developed. The simulation period is separated into three consecutive periods based on the government's intervention strategies: the nonpharmaceutical strategy is used during Period 1. The nonpharmaceutical and antiviral strategies are executed during Period 2 and the vaccine strategy is added during Period 3. During Period 1, we estimate the reduction in the transmission rate due to the government's intervention policies as a difference between the data-fitted and uncontrolled transmission rate that is derived from the basic reproductive number, R0, of the model without intervention...
October 18, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27618867/impact-of-early-diagnosis-on-functional-disability-in-rheumatoid-arthritis
#3
Dam Kim, Chan-Bum Choi, Jiyoung Lee, Soo-Kyung Cho, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Tae-Jong Kim, Eunmi Koh, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Sang-Heon Lee, Shin-Seok Lee, Sung Won Lee, Seung-Cheol Shim, Dae-Hyun Yoo, Bo Young Yoon, Yoon-Kyoung Sung, Sang-Cheol Bae
Background/Aims: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients. Methods: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of ≤ 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group. Demographic characteristics and outcomes were compared between early and delayed diagnosis groups...
September 13, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27506573/eudesmane-type-sesquiterpenoids-from-salvia-plebeia-inhibit-il-6-induced-stat3-activation
#4
Hyun-Jae Jang, Hyun-Mee Oh, Joo Tae Hwang, Mi-Hwa Kim, Soyoung Lee, Kyungsook Jung, Young-Ho Kim, Seung Woong Lee, Mun-Chual Rho
Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1...
October 2016: Phytochemistry
https://www.readbyqxmd.com/read/27478341/differences-in-utilization-patterns-among-medications-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-36-month-retrospective-study-using-the-korean-health-insurance-review-and-assessment-claims-database
#5
Soo-Young Bhang, Jun-Won Hwang, Young-Sook Kwak, Yoo Sook Joung, Soyoung Lee, Bongseog Kim, Seok Han Sohn, Un Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung Yun Choi, In-Hwan Oh, Yeon Jung Lee
We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and adolescents with ADHD who were not given their newly prescribed medication in 360 days before the initial claim in 2010...
August 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27377134/an-amphiphilic-peptide-induces-apoptosis-through-the-mir29b-p53-pathway-in-cancer-cells
#6
Soyoung Kim, Jung Hyun Lee, Igojo Kang, Soonsil Hyun, Jaehoon Yu, Chanseok Shin
Peptides have been in the limelight, as therapeutic agents for cancer treatment through various applications due to their high target selectivity and exceptional ability to penetrate the cell membrane. Recent studies have revealed that synthesized peptides bind to hairpin structures of RNA that affect their activities such as changing the efficacy of microRNA maturation. MicroRNA-mediated p53 activation by the microRNA-29 (miR29) family is one of the most important regulatory pathways in cancer therapeutics...
2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27373668/sesquiterpenoids-from-the-rhizomes-of-curcuma-phaeocaulis-and-their-inhibitory-effects-on-lps-induced-tlr4-activation
#7
Hyun-Jae Jang, Jin-Han Kim, Hyun-Mee Oh, Min-Suk Kim, Jin Ha Jo, Kyungsook Jung, Soyoung Lee, Young-Ho Kim, Woo Song Lee, Seung Woong Lee, Mun-Chual Rho
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27317249/a-randomized-controlled-trial-of-an-educational-video-to-improve-quality-of-bowel-preparation-for-colonoscopy
#8
Jin-Seok Park, Min Su Kim, HyungKil Kim, Shin Il Kim, Chun Ho Shin, Hyun Jung Lee, Won Seop Lee, Soyoung Moon
BACKGROUND: High-quality bowel preparation is necessary for colonoscopy. A few studies have been conducted to investigate improvement in bowel preparation quality through patient education. However, the effect of patient education on bowel preparation has not been well studied. METHODS: A randomized and prospective study was conducted. All patients received regular instruction for bowel preparation during a pre-colonoscopy visit. Those scheduled for colonoscopy were randomly assigned to view an educational video instruction (video group) on the day before the colonoscopy, or to a non-video (control) group...
2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27302160/inhibiting-dx2-p14-arf-interaction-exerts-antitumor-effects-in-lung-cancer-and-delays-tumor-progression
#9
Ah-Young Oh, Youn Sang Jung, Jiseon Kim, Jee-Hyun Lee, Jung-Hyun Cho, Ho-Young Chun, Soyoung Park, Hyunchul Park, Sikeun Lim, Nam-Chul Ha, Jong Sook Park, Choon-Sik Park, Gyu-Yong Song, Bum-Joon Park
The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression was induced by oncogenes in human lung cancer tissues and cells. DX2 prevented oncogene-induced apoptosis and senescence and promoted drug resistance by directly binding to and inhibiting p14/ARF...
August 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27134486/knowledge-and-perception-about-clinical-research-shapes-behavior-face-to-face-survey-in-korean-general-public
#10
Yun Jung Choi, Sung-Ho Beck, Woon Yong Kang, Soyoung Yoo, Seong-Yoon Kim, Ji Sung Lee, Tal Burt, Tae Won Kim
Considering general public as potential patients, identifying factors that hinder public participation poses great importance, especially in a research environment where demands for clinical trial participants outpace the supply. Hence, the aim of this study was to evaluate knowledge and perception about clinical research in general public. A total of 400 Seoul residents with no previous experience of clinical trial participation were selected, as representative of population in Seoul in terms of age and sex...
May 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27109161/lipin1-mediated-repression-of-adipogenesis-by-rutin
#11
Yo-Han Han, Ji-Ye Kee, Jinbong Park, Dae-Seung Kim, Soyoung Shin, Dong-Hyun Youn, JongWook Kang, Yunu Jung, Young-Mi Lee, Jin-Han Park, Su-Jin Kim, Jae-Young Um, Seung-Heon Hong
Rutin, also called rutoside or quercetin-3-O-rutinoside and sophorin, is a glycoside between the flavonol quercetin and the disaccharide rutinose. Although many effects of rutin have been reported in vitro and in vivo, the anti-adipogenic effects of rutin have not been fully reported. The aim of this study was to confirm how rutin regulates adipocyte related factors. In this study, rutin decreased the expressions of adipogenesis-related genes, including peroxisome proliferators, activated receptor [Formula: see text] (PPAR[Formula: see text], CCAAT/enhancer-binding protein [Formula: see text] (C/EBP[Formula: see text], fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase in 3T3-L1 cells...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/26852013/arctigenin-inhibits-adipogenesis-by-inducing-ampk-activation-and-reduces-weight-gain-in-high-fat-diet-induced-obese-mice
#12
Yo-Han Han, Ji-Ye Kee, Jinbong Park, Hye-Lin Kim, Mi-Young Jeong, Dae-Seung Kim, Yong-Deok Jeon, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Hong-Seob So, Raekil Park, Jong-Hyun Lee, Soyoung Shin, Su-Jin Kim, Jae-Young Um, Seung-Heon Hong
Although arctigenin (ARC) has been reported to have some pharmacological effects such as anti-inflammation, anti-cancer, and antioxidant, there have been no reports on the anti-obesity effect of ARC. The aim of this study is to investigate whether ARC has an anti-obesity effect and mediates the AMP-activated protein kinase (AMPK) pathway. We investigated the anti-adipogenic effect of ARC using 3T3-L1 pre-adipocytes and human adipose tissue-derived mesenchymal stem cells (hAMSCs). In high-fat diet (HFD)-induced obese mice, whether ARC can inhibit weight gain was investigated...
September 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/26849891/mapping-health-assessment-questionnaire-disability-index-haq-di-score-pain-visual-analog-scale-vas-and-disease-activity-score-in-28-joints-das28-onto-the-euroqol-5d-eq-5d-utility-score-with-the-korean-observational-study-network-for-arthritis-korona-registry
#13
Hye-Lin Kim, Dam Kim, Eun Jin Jang, Min-Young Lee, Hyun Jin Song, Sun-Young Park, Soo-Kyung Cho, Yoon-Kyoung Sung, Chan-Bum Choi, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Tae-Jong Kim, Eunmi Koh, Hwajeong Lee, Hye-Soon Lee, Jisoo Lee, Shin-Seok Lee, Sung Won Lee, Sung-Hoon Park, Seung-Cheol Shim, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Eui-Kyung Lee
The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data)...
April 2016: Rheumatology International
https://www.readbyqxmd.com/read/26647714/ca-%C3%AE-1t-a-fly-t-type-ca2-channel-negatively-modulates-sleep
#14
Kyunghwa Jeong, Soyoung Lee, Haengsoo Seo, Yangkyun Oh, Donghoon Jang, Joonho Choe, Daesoo Kim, Jung-Ha Lee, Walton D Jones
Mammalian T-type Ca(2+) channels are encoded by three separate genes (Cav3.1, 3.2, 3.3). These channels are reported to be sleep stabilizers important in the generation of the delta rhythms of deep sleep, but controversy remains. The identification of precise physiological functions for the T-type channels has been hindered, at least in part, by the potential for compensation between the products of these three genes and a lack of specific pharmacological inhibitors. Invertebrates have only one T-type channel gene, but its functions are even less well-studied...
December 9, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26329343/factors-associated-with-the-use-of-complementary-and-alternative-medicine-for-korean-patients-with-rheumatoid-arthritis
#15
Minkyung Han, Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Soyoung Won, Chan-Bum Choi, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Seong-Kyu Kim, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Joo-Hyun Lee, Shin-Seok Lee, Seong-Su Nah, Seung-Cheol Shim, Dae-Hyun Yoo, Wan-Hee Yoo, Bo Young Yoon, Sun Ha Jee, Sang-Cheol Bae
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic autoimmune disease that is often painful and debilitating. Patients with RA are increasingly receiving complementary and alternative medicine (CAM). We aimed to identify the patient characteristics and disease-specific factors associated with Korean patients with RA who decide to start treatment with CAM. METHODS: Among the total 5371 patients with RA in the KORean Observational study Network for Arthritis (KORONA), 2175 patients who had no experience with CAM were included in our study...
November 2015: Journal of Rheumatology
https://www.readbyqxmd.com/read/26243843/association-between-abacus-training-and-improvement-in-response-inhibition-a-case-control-study
#16
Kyoung-Sae Na, Soyoung Irene Lee, Jun-Ho Park, Han-Yong Jung, Jung-Hee Ryu
OBJECTIVE: The abacus, first used in Asian countries more than 800 years ago, enables efficient arithmetic calculation via visuospatial configuration. We investigated whether abacus-trained children performed better on cognitive tasks and demonstrated higher levels of arithmetic abilities compared to those without such training. METHODS: We recruited 75 elementary school children (43 abacus-trained and 32 not so trained). Attention, memory, and arithmetic abilities were measured, and we compared the abacus with the control group...
August 31, 2015: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26130960/knowledge-and-attitude-of-851-nursing-personnel-toward-depression-in-general-hospitals-of-korea
#17
Seon-Cheol Park, Hwa-Young Lee, Dong-Woo Lee, Sang-Woo Hahn, Sang-Ho Park, Yeo-Ju Kim, Jae Sung Choi, Ho-Sung Lee, Soyoung Irene Lee, Kyoung-Sae Na, Sung Won Jung, Se-Hoon Shim, Joonho Choi, Jong-Woo Paik, Young-Joon Kwon
Our study aimed to examine the knowledge and attitude of nursing personnel toward depression in general hospitals of Korea. A total of 851 nursing personnel enrolled at four university-affiliated general hospitals completed self-report questionnaires. Chi-square tests were used to compare the knowledge and attitude of registered or assistant nurses toward depression. In addition, binary logistic regression analysis was used to adjust for the following confounders: age-group and workplace. Registered and assistant nurses differed in their knowledge and attitude toward depression...
July 2015: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/26117659/rapid-implantation-of-dissolving-microneedles-on-an-electrospun-pillar-array
#18
Huisuk Yang, Soyoung Kim, Inyoung Huh, Suyong Kim, Shayan F Lahiji, Miroo Kim, Hyungil Jung
Dissolving microneedles (DMNs), designed to release drugs and dissolve after skin insertion, have been spotlighted as a novel transdermal delivery system due to their advantages such as minimal pain and tissue damage, ability to self-administer, and no associated hazardous residues. The drug delivery efficacy of DMNs, however, is limited by incomplete insertion and the extended period required for DMN dissolution. Here, we introduce a novel DMN delivery system, DMN on an electrospun pillar array (DEPA), which can rapidly implant DMNs into skin...
September 2015: Biomaterials
https://www.readbyqxmd.com/read/26089158/critical-role-of-ampk-foxo3a-axis-in-globular-adiponectin-induced-cell-cycle-arrest-and-apoptosis-in-cancer-cells
#19
Anup Shrestha, Saroj Nepal, Mi Jin Kim, Jae Hoon Chang, Sang-Hyun Kim, Gil-Saeng Jeong, Chul-Ho Jeong, Gyu Hwan Park, Sunghee Jung, Jaecheong Lim, Eunha Cho, Soyoung Lee, Pil-Hoon Park
Adiponectin predominantly secreted from adipose tissue has exhibited potent anti-proliferative properties in cancer cells via modulating cell cycle and apoptosis. FoxO3A, a Forkhead box O member of the transcription factor, plays a critical role in modulating expression of genes involved in cell death and/or survival. In this study, we investigated the role of FoxO3A signaling in anti-cancer activities of adiponectin. Herein, we have shown that treatment with globular adiponectin (gAcrp) increases p27 but decreases cyclinD1 expression in human hepatoma (HepG2) and breast (MCF-7) cancer cells...
February 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/25932004/natural-course-of-an-untreated-metastatic-perirectal-lymph-node-after-the-endoscopic-resection-of-a-rectal-neuroendocrine-tumor
#20
Sang Hyung Kim, Dong-Hoon Yang, Jung Su Lee, Soyoung Park, Ho-Su Lee, Hyojeong Lee, Sang Hyoung Park, Kyung-Jo Kim, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jin-Ho Kim, Chan Wook Kim, Jihun Kim
Lymph node metastasis is rare in small (i.e., <10 mm) rectal neuroendocrine tumors (NETs). In addition to tumor size, pathological features such as the mitotic or Ki-67 proliferation index are associated with lymph node metastasis in rectal NETs. We recently treated a patient who underwent endoscopic treatment of a small, grade 1 rectal NET that recurred in the form of perirectal lymph node metastasis 7 years later. A 7-mm-sized perirectal lymph node was noted at the time of the initial endoscopic treatment...
April 2015: Intestinal Research
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