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https://www.readbyqxmd.com/read/28699786/inactivation-of-norovirus-by-lemongrass-essential-oil-using-a-norovirus-surrogate-system
#1
Ye Won Kim, Hyun Ju You, Soyoung Lee, Bomi Kim, Do Kyung Kim, Joo-Bong Choi, Ji-Ah Kim, Hee Jung Lee, In Sun Joo, Jeong Su Lee, Dong Hyun Kang, Giljae Lee, Gwang Pyo Ko, Sung-Joon Lee
This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay...
July 12, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28539949/screening-for-depressive-disorder-in-elderly-patients-with-chronic-physical-diseases-using-the-patient-health-questionnaire-9
#2
Seon-Cheol Park, Hwa-Young Lee, Dong-Woo Lee, Sang-Woo Hahn, Sang-Ho Park, Yeo Ju Kim, Jae Sung Choi, Ho-Sung Lee, Soyoung Irene Lee, Kyoung-Sae Na, Sung Won Jung, Se-Hoon Shim, Ki Won Kim, Jong-Woo Paik, Young-Joon Kwon
OBJECTIVE: We aimed to identify depressive symptom profiles that indicated the presence of depressive disorder and present optimal cut-off sub-scores for depressive symptom profiles for detecting depressive disorder in elderly subjects with chronic physical diseases including diabetes, chronic obstructive pulmonary disease/asthma, and coronary artery disease, using the Patient Health Questionnaire-9 (PHQ-9). METHODS: Two hundred and thirty-one elderly patients with chronic physical diseases were recruited consecutively from a university-affiliated general hospital in South Korea...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28480644/similarity-analysis-of-korean-medical-literature-and-its-association-with-efforts-to-improve-research-and-publication-ethics
#3
Soyoung Park, Seung Ho Yang, Eugene Jung, Yeon Mi Kim, Hyun Sung Baek, Young Mo Koo
In the present study, the frequency of research misconduct in Korean medical papers was analyzed using the similarity check software iThenticateĀ®. All Korean papers written in English that were published in 2009 and 2014 in KoreaMed Synapse were identified. In total, 23,848 papers were extracted. 4,050 Journal Articles of them were randomly selected for similarity analysis. The average Similarity Index of the 4,050 papers decreased over time, particularly in 2013: in 2009 and 2014, it was 10.15% and 5.62%, respectively...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28462887/an-acute-pancreatitis-due-to-a-pancreatic-epidermoid-cyst-contrast-endoscopic-ultrasonography
#4
Gun Jung Youn, Chang Nyol Paik, Soyoung Im, Ji-Han Jung
No abstract text is available yet for this article.
June 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28326113/factors-that-affect-the-adherence-to-adhd-medications-during-a-treatment-continuation-period-in-children-and-adolescents-a-nationwide-retrospective-cohort-study-using-korean-health-insurance-data-from-2007-to-2011
#5
Soo-Young Bhang, Young Sook Kwack, Yoo-Sook Joung, Soyoung Irene Lee, Bongseog Kim, Seok Han Sohn, Un-Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung-Yun Choi, In Hwan Oh, Yeon Jung Lee, Jun-Won Hwang
OBJECTIVE: Several factors, such as male gender, older age, type of insurance, comorbid conditions, and medication type, have been associated with attention-deficit/hyperactivity disorder (ADHD) medication adherence rates, but the results have been inconsistent. We analyzed data to answer several questions: 1) How old were patients who first refilled their treatment medications used primarily for ADHD, regardless of the medication type? 2) What socio-demographic factors are associated with medication adherence? 3) What medical conditions, such as medication type and comorbid diagnosis, influence adherence? METHODS: We analyzed National Health Insurance data, which comprised continuously enrolled Korean National Medical Insurance children (6-18 years) with at least 2 ADHD prescription claims (January 2008-December 2011)...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28261302/the-vitamin-d-analogue-paricalcitol-attenuates-hepatic-ischemia-reperfusion-injury-through-down-regulation-of-toll-like-receptor-4-signaling-in-rats
#6
Min Sung Kim, Soyoung Lee, Namhee Jung, Kiho Lee, Jinwoo Choi, Sang-Hoon Kim, Jinhyun Jun, Won-Mee Lee, Yeonsoo Chang, Donghee Kim
INTRODUCTION: Recent studies have revealed that vitamin D and its synthetic analogues have a protective effect on experimental ischemia/reperfusion (I/R) models in several organs, but little is known about its effect on the liver. The aim of this study was to evaluate the beneficial effects of vitamin D in a model of liver I/R in rats, focusing on Toll-like receptor (TLR) 4 signaling, which has been shown to be involved in I/R injury. MATERIAL AND METHODS: Twenty-four male Wistar rats were randomized into four groups: Saline + Sham, Saline + I/R, Paricalcitol + Sham, and Paricalcitol + I/R...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28132102/comparative-effectiveness-of-treatment-options-after-conventional-dmards-failure-in-rheumatoid-arthritis
#7
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Chan-Bum Choi, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Hyoun Ah Kim, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Shin-Seok Lee, Sung Won Lee, Yeon-Ah Lee, Seong-Su Nah, Chang-Hee Suh, Dae-Hyun Yoo, Bo Young Yoon, Sang Cheol Bae
OBJECTIVE: To compare the clinical effectiveness of two treatment strategies for active rheumatoid arthritis (RA) refractory to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs): starting TNF inhibitors (TNFIs) or changing csDMARDs. METHODS: We used two nationwide Korean RA registries for patient selection. TNFI users were selected from the BIOPSY, which is an inception cohort of RA patients starting biologic DMARDs. As a control group, we selected RA patients with moderate or high disease activity from the KORONA database whose treatment was changed to other csDMARDs...
June 2017: Rheumatology International
https://www.readbyqxmd.com/read/28064100/evaluating-the-effects-of-supplemental-rest-areas-on-freeway-crashes-caused-by-drowsy-driving
#8
Soyoung Jung, Shinhye Joo, Cheol Oh
To prevent crashes caused by drowsy driving, supplemental rest areas have been installed in the South Korean freeway system to allow road users to rest. These supplemental rest areas are very small-sized resting facilities located between the larger regular rest areas, which is a unique design. This study aimed to evaluate the effects of the supplemental rest areas on reducing crashes caused by drowsy driving. Between 2011 and 2012, supplemental rest areas were first installed in the Gyeongbu Freeway, which was selected as the study area for this study...
February 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#9
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
February 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27769686/mathematical-model-of-transmission-dynamics-and-optimal-control-strategies-for-2009-a-h1n1-influenza-in-the-republic-of-korea
#10
Soyoung Kim, Jonggul Lee, Eunok Jung
A mathematical model for the transmission dynamics of the 2009 A/H1N1 influenza epidemic in the Republic of Korea is developed. The simulation period is separated into three consecutive periods based on the government's intervention strategies: the nonpharmaceutical strategy is used during Period 1. The nonpharmaceutical and antiviral strategies are executed during Period 2 and the vaccine strategy is added during Period 3. During Period 1, we estimate the reduction in the transmission rate due to the government's intervention policies as a difference between the data-fitted and uncontrolled transmission rate that is derived from the basic reproductive number, R0, of the model without intervention...
January 7, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27618867/impact-of-early-diagnosis-on-functional-disability-in-rheumatoid-arthritis
#11
Dam Kim, Chan-Bum Choi, Jiyoung Lee, Soo-Kyung Cho, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Young Ok Jung, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Tae-Jong Kim, Eunmi Koh, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Sang-Heon Lee, Shin-Seok Lee, Sung Won Lee, Seung-Cheol Shim, Dae-Hyun Yoo, Bo Young Yoon, Yoon-Kyoung Sung, Sang-Cheol Bae
BACKGROUND/AIMS: To determine whether early diagnosis is beneficial for functional status of various disease durations in rheumatoid arthritis (RA) patients. METHODS: A total of 4,540 RA patients were enrolled as part of the Korean Observational Study Network for Arthritis (KORONA). We defined early diagnosis as a lag time between symptom onset and RA diagnosis of ā‰¤ 12 months, whereas patients with a longer lag time comprised the delayed diagnosis group. Demographic characteristics and outcomes were compared between early and delayed diagnosis groups...
July 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27506573/eudesmane-type-sesquiterpenoids-from-salvia-plebeia-inhibit-il-6-induced-stat3-activation
#12
Hyun-Jae Jang, Hyun-Mee Oh, Joo Tae Hwang, Mi-Hwa Kim, Soyoung Lee, Kyungsook Jung, Young-Ho Kim, Seung Woong Lee, Mun-Chual Rho
Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1...
October 2016: Phytochemistry
https://www.readbyqxmd.com/read/27478341/differences-in-utilization-patterns-among-medications-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-36-month-retrospective-study-using-the-korean-health-insurance-review-and-assessment-claims-database
#13
Soo-Young Bhang, Jun-Won Hwang, Young-Sook Kwak, Yoo Sook Joung, Soyoung Lee, Bongseog Kim, Seok Han Sohn, Un Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung Yun Choi, In-Hwan Oh, Yeon Jung Lee
We evaluated the differences in utilization patterns including persistence and adherence among medications in children and adolescents with attention deficit hyperactivity disorder (ADHD). The current study was performed using data from the Korean Health Insurance Review and Assessment claims database from January 1, 2009 to December 31, 2013. Our study sample consisted of 10,343 children and adolescents with ADHD who were not given their newly prescribed medication in 360 days before the initial claim in 2010...
August 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27377134/an-amphiphilic-peptide-induces-apoptosis-through-the-mir29b-p53-pathway-in-cancer-cells
#14
Soyoung Kim, Jung Hyun Lee, Igojo Kang, Soonsil Hyun, Jaehoon Yu, Chanseok Shin
Peptides have been in the limelight, as therapeutic agents for cancer treatment through various applications due to their high target selectivity and exceptional ability to penetrate the cell membrane. Recent studies have revealed that synthesized peptides bind to hairpin structures of RNA that affect their activities such as changing the efficacy of microRNA maturation. MicroRNA-mediated p53 activation by the microRNA-29 (miR29) family is one of the most important regulatory pathways in cancer therapeutics...
2016: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/27373668/sesquiterpenoids-from-the-rhizomes-of-curcuma-phaeocaulis-and-their-inhibitory-effects-on-lps-induced-tlr4-activation
#15
Hyun-Jae Jang, Jin-Han Kim, Hyun-Mee Oh, Min-Suk Kim, Jin Ha Jo, Kyungsook Jung, Soyoung Lee, Young-Ho Kim, Woo Song Lee, Seung Woong Lee, Mun-Chual Rho
Two new guaiane-type (2, 6) and one new furanogermacrane-type (11) sesquiterpenoids have been isolated along with twelve known compounds from an EtOAc-soluble extract of Curcuma phaeocaulis rhizomes. The structures of the isolated compounds were elucidated using a combination of NMR, MS, and circular dichroism (CD) spectra. The inhibitory effects of each compound on lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) activation in THP-1-Blue cells were assessed, and compound 4 showed more potent inhibitory activity against LPS-stimulated TLR4 activation...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27317249/a-randomized-controlled-trial-of-an-educational-video-to-improve-quality-of-bowel-preparation-for-colonoscopy
#16
RANDOMIZED CONTROLLED TRIAL
Jin-Seok Park, Min Su Kim, HyungKil Kim, Shin Il Kim, Chun Ho Shin, Hyun Jung Lee, Won Seop Lee, Soyoung Moon
BACKGROUND: High-quality bowel preparation is necessary for colonoscopy. A few studies have been conducted to investigate improvement in bowel preparation quality through patient education. However, the effect of patient education on bowel preparation has not been well studied. METHODS: A randomized and prospective study was conducted. All patients received regular instruction for bowel preparation during a pre-colonoscopy visit. Those scheduled for colonoscopy were randomly assigned to view an educational video instruction (video group) on the day before the colonoscopy, or to a non-video (control) group...
June 17, 2016: BMC Gastroenterology
https://www.readbyqxmd.com/read/27302160/inhibiting-dx2-p14-arf-interaction-exerts-antitumor-effects-in-lung-cancer-and-delays-tumor-progression
#17
Ah-Young Oh, Youn Sang Jung, Jiseon Kim, Jee-Hyun Lee, Jung-Hyun Cho, Ho-Young Chun, Soyoung Park, Hyunchul Park, Sikeun Lim, Nam-Chul Ha, Jong Sook Park, Choon-Sik Park, Gyu-Yong Song, Bum-Joon Park
The aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2) splice variant designated DX2 is induced by cigarette smoke carcinogens and is often detected in human lung cancer specimens. However, the function of DX2 in lung carcinogenesis is obscure. In this study, we found that DX2 expression was induced by oncogenes in human lung cancer tissues and cells. DX2 prevented oncogene-induced apoptosis and senescence and promoted drug resistance by directly binding to and inhibiting p14/ARF...
August 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27134486/knowledge-and-perception-about-clinical-research-shapes-behavior-face-to-face-survey-in-korean-general-public
#18
Yun Jung Choi, Sung-Ho Beck, Woon Yong Kang, Soyoung Yoo, Seong-Yoon Kim, Ji Sung Lee, Tal Burt, Tae Won Kim
Considering general public as potential patients, identifying factors that hinder public participation poses great importance, especially in a research environment where demands for clinical trial participants outpace the supply. Hence, the aim of this study was to evaluate knowledge and perception about clinical research in general public. A total of 400 Seoul residents with no previous experience of clinical trial participation were selected, as representative of population in Seoul in terms of age and sex...
May 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27109161/lipin1-mediated-repression-of-adipogenesis-by-rutin
#19
Yo-Han Han, Ji-Ye Kee, Jinbong Park, Dae-Seung Kim, Soyoung Shin, Dong-Hyun Youn, JongWook Kang, Yunu Jung, Young-Mi Lee, Jin-Han Park, Su-Jin Kim, Jae-Young Um, Seung-Heon Hong
Rutin, also called rutoside or quercetin-3-O-rutinoside and sophorin, is a glycoside between the flavonol quercetin and the disaccharide rutinose. Although many effects of rutin have been reported in vitro and in vivo, the anti-adipogenic effects of rutin have not been fully reported. The aim of this study was to confirm how rutin regulates adipocyte related factors. In this study, rutin decreased the expressions of adipogenesis-related genes, including peroxisome proliferators, activated receptor [Formula: see text] (PPAR[Formula: see text], CCAAT/enhancer-binding protein [Formula: see text] (C/EBP[Formula: see text], fatty acid synthase, adipocyte fatty acid-binding protein, and lipoprotein lipase in 3T3-L1 cells...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/26852013/arctigenin-inhibits-adipogenesis-by-inducing-ampk-activation-and-reduces-weight-gain-in-high-fat-diet-induced-obese-mice
#20
Yo-Han Han, Ji-Ye Kee, Jinbong Park, Hye-Lin Kim, Mi-Young Jeong, Dae-Seung Kim, Yong-Deok Jeon, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Hong-Seob So, Raekil Park, Jong-Hyun Lee, Soyoung Shin, Su-Jin Kim, Jae-Young Um, Seung-Heon Hong
Although arctigenin (ARC) has been reported to have some pharmacological effects such as anti-inflammation, anti-cancer, and antioxidant, there have been no reports on the anti-obesity effect of ARC. The aim of this study is to investigate whether ARC has an anti-obesity effect and mediates the AMP-activated protein kinase (AMPK) pathway. We investigated the anti-adipogenic effect of ARC using 3T3-L1 pre-adipocytes and human adipose tissue-derived mesenchymal stem cells (hAMSCs). In high-fat diet (HFD)-induced obese mice, whether ARC can inhibit weight gain was investigated...
September 2016: Journal of Cellular Biochemistry
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