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https://www.readbyqxmd.com/read/29050978/chrysin-attenuates-atopic-dermatitis-by-suppressing-inflammation-of-keratinocytes
#1
Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Young-Ae Choi, Meiling Jin, Jung Ho Choi, Jee Hun Park, Pil-Hoon Park, Hyukjae Choi, Taeg Kyu Kwon, Dongwoo Khang, Sang-Hyun Kim
We previously reported the inhibitory effect of chrysin, a natural flavonoid plentifully contained in propolis, vegetables and fruits, on the mast cell-mediated allergic reaction. In this study, we evaluated the effect of chrysin on atopic dermatitis (AD) and defined underlying mechanisms of action. We used an AD model in BALB/c mice by the repeated local exposure of 2,4-dinitrochlorobenzene (DNCB) and house dust mite (Dermatophagoides farinae extract, DFE) to the ears. Repeated alternative treatment of DNCB/DFE caused AD-like skin lesions...
October 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29042887/the-prevalence-of-depression-among-patients-with-the-top-ten-most-common-cancers-in-south-korea
#2
Boram Park, Soyoung Youn, Ki-Kyung Yi, Su-Yeon Lee, Jung-Sun Lee, Seockhoon Chung
OBJECTIVE: Among the various psychiatric disorders, depression is a common comorbid condition in cancer patients. Due to the distinct and diverse nature of cancer, the prevalence of depression may be assumed to be affected by differences in primary cancer sites. In this study, we explored the prevalence rates of depression among the ten most prevalent cancers in South Korea using a national patient sample. METHODS: This was a 1-year cross-sectional study using a national patient sample provided by the South Korean National Health Insurance in 2011...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28990098/anti%C3%A2-inflammatory-effect-of-amomum%C3%A2-xanthioides-in-a-mouse-atopic-dermatitis-model
#3
Young-Ae Choi, Jin Kyeong Choi, Yong Hyun Jang, Soyoung Lee, Sang-Rae Lee, Jung Ho Choi, Jee Hun Park, Tae-Yong Shin, Sang-Hyun Kim
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. However, oral administration of AXE reduced these histopathological alterations in a dose‑dependent manner...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28960981/anti-inflammatory-activity-of-eudesmane-type-sesquiterpenoids-from-salvia-plebeia
#4
Hyun-Jae Jang, Soyoung Lee, Seung-Jae Lee, Hyung-Jin Lim, Kyungsook Jung, Young Ho Kim, Seung Woong Lee, Mun-Chual Rho
Nine new sesquiterpenoid lactones and 11 known analogues were isolated from the aerial parts of Salvia plebeia R.Br. Their structures were elucidated via HRESIMS and NMR data, and their absolute configurations were defined via electronic circular dichroism data, X-ray crystallographic analysis, and the modified Mosher's ester method. Compounds 1-20 were investigated for their ability to inhibit LPS-stimulated nitric oxide production in murine macrophage cells. Of the isolates, epi-eudebeiolide C (20) showed the highest inhibitory effect (IC50 of 17...
October 27, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28956367/excessive-iodine-status-among-school-age-children-in-korea-a-first-report
#5
Young Sik Choi, Soyoung Ock, Sukyoung Kwon, Sang Bong Jung, Kwang Hyuk Seok, Young Jin Kim, Bu Kyung Kim, Jee Yeong Jeong
BACKGROUND: Korea is considered an iodine sufficient country, and several studies have been conducted regarding iodine status in healthy Korean adults, pregnant women, and preschool children. However, data on iodine status in Korean school-age children are lacking. Therefore, the iodine nutrition status of Korean school-age children was investigated by measuring urine iodine concentration (UIC). METHODS: This cross-sectional study conducted between April and September 2016 comprised 373 school-age children...
September 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28946703/acyclic-triterpenoids-from-alpinia-katsumadai-inhibit-il-6-induced-stat3-activation
#6
Hyun-Jae Jang, Seung-Jae Lee, Soyoung Lee, Kyungsook Jung, Seung Woong Lee, Mun-Chual Rho
The seeds of Alpinia katsumadai yielded two new acyclic triterpenoids, 2,3,6,22,23-pentahydroxy-2,6,11,15,19,23-hexamethyl-tetracosa-7,10,14,18-tetraene (3) and 2,3,6,22,23-pentahydroxy-2,10,15,19,23-hexamethyl-7-methylenetetracosa-10,14,18-triene (4), as well as two known compounds, 2,3,22,23-tertrahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (1) and 2,3,5,22,23-pentahydroxy-2,6,10,15,19,23-hexamethyl-tetracosa-6,10,14,18-tetraene (2). The absolute configurations of 2 and 3, which were determined by means of a modified Mosher's method, are suggested as (3R; 5S; 22R) and (3R; 22R), respectively...
September 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28922036/location-and-modality-effects-in-online-dating-rich-modality-profile-and-location-based-information-cues-increase-social-presence-while-moderating-the-impact-of-uncertainty-reduction-strategy
#7
Soyoung Jung, Soojin Roh, Hyun Yang, Frank Biocca
This study investigates how different interface modality features of online dating sites, such as location awareness cues and modality of profiles, affect the sense of social presence of a prospective date. We also examined how various user behaviors aimed at reducing uncertainty about online interactions affect social presence perceptions and are affected by the user interface features. Male users felt a greater sense of social presence when exposed to both location and accessibility cues (geographical proximity) and a richer medium (video profiles)...
September 2017: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/28869355/black-pigment-gallstone-inspired-platinum-chelated-bilirubin-nanoparticles-for-combined-photoacoustic-imaging-and-photothermal-therapy-of-cancers
#8
Dong Yun Lee, Jin Yong Kim, Yonghyun Lee, Soyoung Lee, Wenjun Miao, Hyeon Sik Kim, Jung-Joon Min, Sangyong Jon
Bilirubin (BR), a bile pigment that exerts potent antioxidant and anti-inflammatory effects, is also a major constituent of black pigment gallstones found in bile ducts under certain pathological conditions. Inspired by the intrinsic metal-chelating power of BR found in gallstones, herein we report a cisplatin-chelated BR-based nanoparticle (cisPt@BRNP) for use as a new photonic nanomedicine for combined photoacoustic imaging and photothermal therapy of cancers. The cisPt@BRNPs were prepared by simply mixing cisplatin with BRNPs, yielding ca...
September 4, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28825663/efficacy-of-repeated-botulinum-toxin-type-a-injections-for-spastic-equinus-in-children-with-cerebral-palsy-a-secondary-analysis-of-the-randomized-clinical-trial
#9
Bo Young Hong, Hyun Jung Chang, Sang-Jee Lee, Soyoung Lee, Joo Hyun Park, Jeong-Yi Kwon
Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, randomized, prospective phase III clinical trial of botulinum toxin A for the treatment of dynamic equinus in 144 children with cerebral palsy was performed to compare the efficacies of letibotulinumtoxin A and onabotulinumtoxin A...
August 21, 2017: Toxins
https://www.readbyqxmd.com/read/28820439/efficacy-and-safety-of-letibotulinum-toxin-a-for-the-treatment-of-dynamic-equinus-foot-deformity-in-children-with-cerebral-palsy-a-randomized-controlled-trial
#10
Hyun Jung Chang, Bo Young Hong, Sang-Jee Lee, Soyoung Lee, Joo Hyun Park, Jeong-Yi Kwon
The objective of this clinical trial was to compare the efficacy and safety of letibotulinum toxin A and onabotulinum toxin A for improving dynamic equinus foot deformity in children with cerebral palsy (CP). In total, 144 children with spastic CP who had dynamic equinus foot deformity were assigned randomly to the Botulax group (injection of letibotulinum toxin A) or the Botox group (injection of onabotulinum toxin A). The Physician's Rating Scale (PRS), ankle plantar flexor spasticity using the Modified Tardieu Scale, the Gross Motor Function Measure (GMFM)-88, and the GMFM-66 were completed before injection and at 6, 12, and 24 weeks after injection...
August 18, 2017: Toxins
https://www.readbyqxmd.com/read/28699786/inactivation-of-norovirus-by-lemongrass-essential-oil-using-a-norovirus-surrogate-system
#11
Ye Won Kim, Hyun Ju You, Soyoung Lee, Bomi Kim, Do Kyung Kim, Joo-Bong Choi, Ji-Ah Kim, Hee Jung Lee, In Sun Joo, Jeong Su Lee, Dong Hyun Kang, Giljae Lee, Gwang Pyo Ko, Sung-Joon Lee
This study investigated the effect of lemongrass essential oil (LGEO) on the infectivity and viral replication of norovirus. Murine norovirus 1 (MNV-1), a surrogate of human norovirus, was preincubated with LGEO and then used to infect RAW 264.7 cells in a plaque reduction assay. LGEO exhibited a significant reduction in MNV-1 plaque formation in both time- and dose-dependent manners. The quantification of viral genome by quantitative real-time PCR showed similar results in line with those of the plaque reduction assay...
August 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28539949/screening-for-depressive-disorder-in-elderly-patients-with-chronic-physical-diseases-using-the-patient-health-questionnaire-9
#12
Seon-Cheol Park, Hwa-Young Lee, Dong-Woo Lee, Sang-Woo Hahn, Sang-Ho Park, Yeo Ju Kim, Jae Sung Choi, Ho-Sung Lee, Soyoung Irene Lee, Kyoung-Sae Na, Sung Won Jung, Se-Hoon Shim, Ki Won Kim, Jong-Woo Paik, Young-Joon Kwon
OBJECTIVE: We aimed to identify depressive symptom profiles that indicated the presence of depressive disorder and present optimal cut-off sub-scores for depressive symptom profiles for detecting depressive disorder in elderly subjects with chronic physical diseases including diabetes, chronic obstructive pulmonary disease/asthma, and coronary artery disease, using the Patient Health Questionnaire-9 (PHQ-9). METHODS: Two hundred and thirty-one elderly patients with chronic physical diseases were recruited consecutively from a university-affiliated general hospital in South Korea...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28480644/similarity-analysis-of-korean-medical-literature-and-its-association-with-efforts-to-improve-research-and-publication-ethics
#13
Soyoung Park, Seung Ho Yang, Eugene Jung, Yeon Mi Kim, Hyun Sung Baek, Young Mo Koo
In the present study, the frequency of research misconduct in Korean medical papers was analyzed using the similarity check software iThenticate®. All Korean papers written in English that were published in 2009 and 2014 in KoreaMed Synapse were identified. In total, 23,848 papers were extracted. 4,050 Journal Articles of them were randomly selected for similarity analysis. The average Similarity Index of the 4,050 papers decreased over time, particularly in 2013: in 2009 and 2014, it was 10.15% and 5.62%, respectively...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28462887/an-acute-pancreatitis-due-to-a-pancreatic-epidermoid-cyst-contrast-endoscopic-ultrasonography
#14
Gun Jung Youn, Chang Nyol Paik, Soyoung Im, Ji-Han Jung
No abstract text is available yet for this article.
June 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28326113/factors-that-affect-the-adherence-to-adhd-medications-during-a-treatment-continuation-period-in-children-and-adolescents-a-nationwide-retrospective-cohort-study-using-korean-health-insurance-data-from-2007-to-2011
#15
Soo-Young Bhang, Young Sook Kwack, Yoo-Sook Joung, Soyoung Irene Lee, Bongseog Kim, Seok Han Sohn, Un-Sun Chung, Jaewon Yang, Minha Hong, Geon Ho Bahn, Hyung-Yun Choi, In Hwan Oh, Yeon Jung Lee, Jun-Won Hwang
OBJECTIVE: Several factors, such as male gender, older age, type of insurance, comorbid conditions, and medication type, have been associated with attention-deficit/hyperactivity disorder (ADHD) medication adherence rates, but the results have been inconsistent. We analyzed data to answer several questions: 1) How old were patients who first refilled their treatment medications used primarily for ADHD, regardless of the medication type? 2) What socio-demographic factors are associated with medication adherence? 3) What medical conditions, such as medication type and comorbid diagnosis, influence adherence? METHODS: We analyzed National Health Insurance data, which comprised continuously enrolled Korean National Medical Insurance children (6-18 years) with at least 2 ADHD prescription claims (January 2008-December 2011)...
March 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28261302/the-vitamin-d-analogue-paricalcitol-attenuates-hepatic-ischemia-reperfusion-injury-through-down-regulation-of-toll-like-receptor-4-signaling-in-rats
#16
Min Sung Kim, Soyoung Lee, Namhee Jung, Kiho Lee, Jinwoo Choi, Sang-Hoon Kim, Jinhyun Jun, Won-Mee Lee, Yeonsoo Chang, Donghee Kim
INTRODUCTION: Recent studies have revealed that vitamin D and its synthetic analogues have a protective effect on experimental ischemia/reperfusion (I/R) models in several organs, but little is known about its effect on the liver. The aim of this study was to evaluate the beneficial effects of vitamin D in a model of liver I/R in rats, focusing on Toll-like receptor (TLR) 4 signaling, which has been shown to be involved in I/R injury. MATERIAL AND METHODS: Twenty-four male Wistar rats were randomized into four groups: Saline + Sham, Saline + I/R, Paricalcitol + Sham, and Paricalcitol + I/R...
March 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28132102/comparative-effectiveness-of-treatment-options-after-conventional-dmards-failure-in-rheumatoid-arthritis
#17
Yoon-Kyoung Sung, Soo-Kyung Cho, Dam Kim, Chan-Bum Choi, Soyoung Won, So-Young Bang, Hoon-Suk Cha, Jung-Yoon Choe, Won Tae Chung, Seung-Jae Hong, Jae-Bum Jun, Hyoun Ah Kim, Jinseok Kim, Seong-Kyu Kim, Tae-Hwan Kim, Hye-Soon Lee, Jaejoon Lee, Jisoo Lee, Shin-Seok Lee, Sung Won Lee, Yeon-Ah Lee, Seong-Su Nah, Chang-Hee Suh, Dae-Hyun Yoo, Bo Young Yoon, Sang Cheol Bae
OBJECTIVE: To compare the clinical effectiveness of two treatment strategies for active rheumatoid arthritis (RA) refractory to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs): starting TNF inhibitors (TNFIs) or changing csDMARDs. METHODS: We used two nationwide Korean RA registries for patient selection. TNFI users were selected from the BIOPSY, which is an inception cohort of RA patients starting biologic DMARDs. As a control group, we selected RA patients with moderate or high disease activity from the KORONA database whose treatment was changed to other csDMARDs...
June 2017: Rheumatology International
https://www.readbyqxmd.com/read/28064100/evaluating-the-effects-of-supplemental-rest-areas-on-freeway-crashes-caused-by-drowsy-driving
#18
Soyoung Jung, Shinhye Joo, Cheol Oh
To prevent crashes caused by drowsy driving, supplemental rest areas have been installed in the South Korean freeway system to allow road users to rest. These supplemental rest areas are very small-sized resting facilities located between the larger regular rest areas, which is a unique design. This study aimed to evaluate the effects of the supplemental rest areas on reducing crashes caused by drowsy driving. Between 2011 and 2012, supplemental rest areas were first installed in the Gyeongbu Freeway, which was selected as the study area for this study...
February 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27858139/lactobacillus-plantarum-hac01-regulates-gut-microbiota-and-adipose-tissue-accumulation-in-a-diet-induced-obesity-murine-model
#19
Soyoung Park, Yosep Ji, Hoe-Yune Jung, Hyunjoon Park, Jihee Kang, Sang-Haeng Choi, Heuynkil Shin, Chang-Kee Hyun, Kyong-Tai Kim, Wilhelm H Holzapfel
The functional features of Lactobacillus plantarum HAC01 (HAC01), isolated from fermented Korean kimchi, were studied with regard to the fat mass, immunometabolic biomarkers and dysbiosis in a diet-induced obesity (DIO) murine model. L. rhamnosus GG (LGG) served as reference strain and a PBS-treated group as control. The administration of L. plantarum HAC01 resulted in reduction of the mesenteric adipose depot, the conjunctive tissue closely associated with the gastrointestinal tract, where lipid oxidative gene expression was upregulated compared to the control group...
February 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27769686/mathematical-model-of-transmission-dynamics-and-optimal-control-strategies-for-2009-a-h1n1-influenza-in-the-republic-of-korea
#20
Soyoung Kim, Jonggul Lee, Eunok Jung
A mathematical model for the transmission dynamics of the 2009 A/H1N1 influenza epidemic in the Republic of Korea is developed. The simulation period is separated into three consecutive periods based on the government's intervention strategies: the nonpharmaceutical strategy is used during Period 1. The nonpharmaceutical and antiviral strategies are executed during Period 2 and the vaccine strategy is added during Period 3. During Period 1, we estimate the reduction in the transmission rate due to the government's intervention policies as a difference between the data-fitted and uncontrolled transmission rate that is derived from the basic reproductive number, R0, of the model without intervention...
January 7, 2017: Journal of Theoretical Biology
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