Da-Eun Cho, Joon-Pyo Hong, Yoongeun Kim, Ju Yeon Sim, Heenam Stanley Kim, Song-Rae Kim, Bombi Lee, Hyo-Sung Cho, Ik-Hyun Cho, Sooan Shin, Mijung Yeom, Soon-Kyeong Kwon, In-Seon Lee, Hijoon Park, Kyuseok Kim, Dae-Hyun Hahm
Psychological stress and intestinal leakage are key factors in atopic dermatitis (AD) recurrence and exacerbation. Here, we demonstrate the mechanism underlying bacterial translocation across intestinal epithelial barrier damaged due to stress and further aggravation of trimellitic anhydride (TMA)-induced itch, which remain unclear, in AD mice. Immobilization (IMO) stress exacerbated scratching bouts and colon histological damage, and increased serum corticosterone and lipopolysaccharide (LPS). Orally administered fluorescein isothiocyanate (FITC)-dextran and surgically injected (into the colon) Cy5...
March 15, 2024: Scientific Reports