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https://www.readbyqxmd.com/read/29683683/sequentially-responsive-therapeutic-peptide-assembling-nanoparticles-for-dual-targeted-cancer-immunotherapy
#1
Keman Cheng, Yanping Ding, Ying Zhao, Shefang Ye, Xiao Zhao, Yinlong Zhang, Tianjiao Ji, Huanhuan Wu, Bin Wang, Gregory J Anderson, Lei Ren, Guangjun Nie
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential for steady co-delivery of various drugs, especially small molecules, therapeutic peptides, and nucleic acids, thereby realizing controllable drug release, increase of drug bioavailability and reduction of adverse effects. Herein, a therapeutic peptide assembling nanoparticle that can sequentially respond to dual stimuli in the tumor extracellular matrix was designed for tumor-targeted delivery and on-demand release of a short D-peptide antagonist of programmed cell death-ligand 1 (D PPA-1) and an inhibitor of idoleamine 2, 3-dioxygenase (NLG919)...
April 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29679953/antinociception-by-the-anti-oxidized-phospholipid-antibody-e06
#2
Milad Mohammadi, Beatrice Oehler, Jan Kloka, Corinna Martin, Alexander Brack, Robert Blum, Heike L Rittner
BACKGROUND AND PURPOSE: Reactive oxygen species (ROS) and their downstream molecules such as oxidized phospholipids (OxPL) and 4-hydroxynonenal (4-HNE) activate transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) ion channels in vivo and in vitro shaping thermal and mechanical hypersensitivity in inflammatory pain. E06/T15 is a monoclonal autoantibody against oxidized phosphatidylcholine (OxPC) used in diagnostics in arteriosclerosis. Recently, we provided evidence that E06 also ameliorates inflammatory pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29677794/synthesis-and-properties-of-fluorinated-styrene-copolymers-as-antibiofouling-coatings
#3
Jong-Woon Ha, Hea Jung Park, Junhoo Park, Inwon Lee, Hyun Park, Hoyoul Kong, Jong Mok Park, Do-Hoon Hwang
A series of polystyrene (PS) copolymers containing 2,3,4,5,6-pentafluorostyrene units with different monomer ratios were prepared for antifouling applications. PS, poly(styrene-co-pentafluorostyrene) (poly(S-co-FS)), and poly(pentafluorostyrene) (PFS) were synthesized by free-radical polymerization and characterized by 1H NMR, Fourier-transform infrared spectroscopy, and gel permeation chromatography. The surface energy of the polymer films decreased with increasing content of fluorinated styrene. Protein adsorption experiments were carried out on the synthesized polymer films using fluorescein isothiocyanate-labeled bovine serum albumin as a fluorescent protein...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29675564/fibrous-matrix-component-of-cell-wall-in-the-giant-celled-green-alga-valonia-utricularis-observed-by-atomic-force-microscopy-in-liquid
#4
Ichiro Mine, Satoko Sekida
The cell walls of the giant-celled green alga Valonia exhibit the "crossed-fibril" arrangement of cellulose microfibrils (CMFs). The existence of fibrous matrix components coiling around the CMFs was recently reported using atomic force microscopy (AFM). To understand the biological role of this fibrous wall component, we attempted to reveal the detailed morphology of the fibrous structure of the cell walls isolated from V. utricularis specimens in artificial seawater (ASW), by using an improved method of AFM...
April 20, 2018: Protoplasma
https://www.readbyqxmd.com/read/29671807/formation-of-sulforaphane-and-iberin-products-from-thai-cabbage-fermented-by-myrosinase-positive-bacteria
#5
Vijitra Luang-In, Sirirat Deeseenthum, Piyachat Udomwong, Worachot Saengha, Matteo Gregori
Myrosinase-positive bacteria from local fermented foods and beverages in Thailand with the capacity to metabolize glucosinolate and produce isothiocyanates (ITCs) were isolated and used as selected strains for Thai cabbage fermentation. Enterobacter xiangfangensis 4A-2A3.1 (EX) from fermented fish and Enterococcus casseliflavus SB2X2 (EC) from fermented cabbage were the two highest ITC producers among seventeen strains identified by 16S rRNA technique. EC and EX were used to ferment Thai cabbage ( Brassica oleracea L...
April 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29671091/prolonged-phonation-impairs-the-integrity-and-barrier-function-of-porcine-vocal-fold-epithelium-a-preliminary-study
#6
Chi Zhang, Kieran Paddock, Adriana Chou, Austin Scholp, Ting Gong, Jack J Jiang
PURPOSE: Voice abuse is known to be a common risk factor of voice disorders and prolonged; high-intensity phonation has been shown to damage the vocal fold epithelium. We aim to evaluate the effects of phonation on the integrity and barrier function of vocal fold epithelium using a porcine laryngeal model. METHODS: Ex vivo porcine larynges were phonated at low intensity or high intensity for 15, 30, or 60 min within 4 h after harvest. Vocal fold epithelium was visualized using transmission electron microscopy (TEM)...
April 18, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29669958/allyl-isothiocyanate-reduces-liver-fibrosis-by-regulating-kupffer-cell-activation-in-rats
#7
Jeongtae Kim, Hyojin Bang, Meejung Ahn, Yuna Choi, Gi Ok Kim, Taekyun Shin
Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl4 ). This study evaluated whether AITC reduces hepatic fibrosis in rats repetitively exposed to CCl4 . Serum chemistry showed that AITC (doses of 5 and 50 mg) administered to rats exposed to CCl4 significantly reduced the levels of alanine aminotransferase and aspartate aminotransferase activity that were elevated in CCl4 -intoxicated rats. The connective tissue in AITC-treated rats was significantly reduced based on Sirius staining...
April 17, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29668110/phenylbutyl-isoselenocyanate-induces-reactive-oxygen-species-to-inhibit-androgen-receptor-and-to-initiate-p53-mediated-apoptosis-in-lncap-prostate-cancer-cells
#8
Wei Wu, Deepkamal Karelia, Kartick Pramanik, Shantu G Amin, Arun K Sharma, Cheng Jiang, Junxuan Lu
Previous studies have established the in vivo bioavailability and efficacious dosages of phenylbutyl isoselenocyanate (ISC-4), a selenium-substituted isothiocyanate, against mouse xenograft models of human melanoma and colorectal cancer. To explore its potential attributes against prostate cancer, we treated human LNCaP prostate cancer cells with ISC-4 and examined their apoptosis responses, and interrogated the signaling mechanisms through pharmacological and siRNA knockdown approaches. Our results show that ISC-4 was more potent at inducing apoptosis than its sulfur analog phenylbutyl isothiocyanate (PBITC) without suppressing protein kinase AKT Ser473 phosphorylation...
April 18, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29667773/benzyl-isothiocyanate-attenuates-the-hydrogen-peroxide-induced-interleukin-13-expression-through-glutathione-s-transferase-p-induction-in-t-lymphocytic-leukemia-cells
#9
Yue Tang, Sho Naito, Naomi Abe-Kanoh, Seiji Ogawa, Shu Yamaguchi, Beiwei Zhu, Yoshiyuki Murata, Yoshimasa Nakamura
We investigated the effect of benzyl isothiocyanate (BITC) on the hydrogen peroxide-induced gene expression of a T-helper-2 cytokine, interleukin (IL)-13, in T lymphocytic leukemia Jurkat cells. The 24-h pretreatment of BITC significantly inhibited the IL-13 expression enhanced by hydrogen peroxide. Although the BITC pretreatment did not change the enhanced level of the phosphorylated c-Jun N-terminal kinase (JNK), it significantly inhibited the nuclear translocation of c-Jun induced by hydrogen peroxide. BITC also increased the protein expression of glutathione S-transferase (GST) isozymes, GSTP1/2, as well as the total GST activity...
April 18, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29667627/propofol-inhibits-hela-cells-by-impairing-autophagic-flux-via-amp-activated-protein-kinase-ampk-activation-and-endoplasmic-reticulum-stress-regulated-by-calcium
#10
Xi Chen, Kai Li, Guoqing Zhao
BACKGROUND Propofol has antitumor effects against various cancers. However, the mechanism of action of propofol in HeLa human cervical cancer cells has not been elucidated. MATERIAL AND METHODS We treated HeLa human cervical cancer cells with different concentrations of propofol. Cell viability was evaluated with Cell Counting Kit-8 and apoptosis was analyzed by annexin V-fluorescein isothiocyanate and propidium iodide staining and flow cytometry. Autophagosome formation was evaluated based on microtubule-associated protein light chain (LC)3 conversion and light chain 3 puncta formation...
April 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29666895/suppression-of-glutathione-s-transferases-potentiates-the-cytotoxic-effect-of-phenethyl-isothiocyanate-in-cholangiocarcinoma-cells
#11
Ornanong Tusskorn, Tueanjai Khunluck, Auemduan Prawan, Laddawan Senggunprai, Upa Kukongviriyapan, Veerapol Kukongviriyapan
Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables. Previous studies have shown that the effect of PEITC-induced cell death declines rapidly after administration. The metabolic fate of PEITC is modulated by glutathione S-transferases (GST). In this study, we investigated whether GST activity modulates PEITC-induced cytotoxicity on cholangiocarcinoma (CCA) cells. The sensitivity of KKU-M214 and KKU-100 cells to PEITC was associated with GST activity...
April 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29665679/can-the-electron-accepting-properties-of-odorants-be-involved-in-their-recognition-by-the-olfactory-system
#12
Stanislav Anatolievich Pshenichnyuk, Rustam Rakhmeyev, Nail Asfandiarov, Alexei S Komolov, Alberto Modelli, Derek Jones
The present study examines the possible importance of the electron-accepting properties of odorant molecules and, in particular, the formation and decay of temporary negative ions via low-energy electron attachment, as a possible contribution towards understanding odorant recognition by olfactory receptors (OR). Fragments formed by dissociative electron attachment (DEA) of mustard oil odorants represented by a series of isothiocyanates are studied experimentally using DEA spectroscopy and DFT calculations. Relative intensities for the most abundant fragment species, S- and SCN-, are found to be characteristic for structurally similar odorants under investigation...
April 17, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29663679/the-role-of-cruciferous-vegetables-and-isothiocyanates-for-lung-cancer-prevention-current-status-challenges-and-future-research-directions
#13
REVIEW
Zhenzhen Zhang, Raymond Bergan, Jackilen Shannon, Christopher G Slatore, Gerd Bobe, Yumie Takata
Lung cancer remains a leading cause of cancer-related deaths in the United States. Although smoking and air pollution exposure are primary risk factors of lung cancer, diet has also been reported to contribute to lung cancer risk. Cruciferous vegetables contain many bioactive compounds that alter the detoxification process of air-borne carcinogenic compounds and, thereby, may decrease lung cancer risk. In our meta-analysis of 31 observational studies, cruciferous vegetable intake was inversely associated with lung cancer risk (summary odds ratio/relative risk = 0...
April 16, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29661933/interleukin-22-immunotherapy-during-severe-influenza-enhances-lung-tissue-integrity-and-reduces-secondary-bacterial-systemic-invasion
#14
Adeline Barthelemy, Valentin Sencio, Daphnée Soulard, Lucie Deruyter, Christelle Faveeuw, Ronan Le Goffic, François Trottein
Severe bacterial (pneumococcal) infections are commonly associated with influenza and are significant contributors to the excess morbidity and mortality of influenza. Disruption of lung tissue integrity during influenza participates in bacterial pulmonary colonization and dissemination out of the lungs. Interleukin (IL)-22 has gained considerable interest in anti-inflammatory and anti-infection immunotherapy over the last decade. In the current study, we investigated the effect of exogenous IL-22 delivery on the outcome of pneumococcal superinfection post-influenza...
April 16, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29660407/application-of-water-soluble-polyvinyl-alcohol-based-film-patches-on-laser-microporated-skin-facilitates-intradermal-macromolecule-and-nanoparticle-delivery
#15
Laura Engelke, Gerhard Winter, Julia Engert
The intradermal delivery of biologics has long been recognized as attractive approach for cutaneous immunotherapy, particularly vaccination. Although intradermal (i.d.) or subcutaneous (s.c.) injection provide reproducible dosing and good cost- and delivery efficiency, the major objective to avoid sharps and the need for enhanced storage stability have renewed the interest in alternative needle-free delivery strategies. This study presents a new concept for the delivery of macromolecules and nanoparticles to viable skin layers with a high density of professional antigen-presenting cells (APCs)...
April 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29658611/effects-of-nicotine-on-the-metabolism-and-gene-expression-profile-of-sprague%C3%A2-dawley-rat-primary-osteoblasts
#16
Dan Liang, Ke-Jing Wang, Zhi-Qun Tang, Run-He Liu, Fulei Zeng, Miao-Ying Cheng, Qi-Si Lian, Hong-Kun Wu
Smoking is a risk factor associated with bone and oral diseases, particularly periodontitis. Nicotine, the major toxic component of tobacco, is able to affect the quality and quantity of bone. Osteoblasts serve an important role in bone formation. Thus far, the effects of nicotine on metabolism‑associated gene and protein expression in osteoblasts have been controversial and the mechanisms remain unclear. The present study assessed alterations in osteogenic activity by performing a Cell Counting kit‑8 assay to investigate proliferation, Annexin V‑fluorescein isothiocyanate/propidium iodide staining to investigate apoptosis, alizarin red staining to investigate the formation of mineralized nodules, reverse transcription‑quantitative polymerase chain reaction and western blotting to investigate the mRNA and protein levels of collagen I, alkaline phosphatase, bone osteocalcin, bone sialoprotein and osteopontin; and mRNA microarray expression analysis, Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analysis to investigate the whole genome expression profile of Sprague‑Dawley (SD) rat primary osteoblasts following treatment with different concentrations of nicotine...
April 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29656506/enantiospecific-total-syntheses-of-hapalindole-h-and-12-epi-hapalindole-u
#17
Dattatraya Hanumant Dethe, Saikat Das, Vijay Kumar B, Nisar Ahmed Mir
Enantiospecific total syntheses of (+)-hapalindole H, (-)-12-epi-hapalindole U, formal synthesis of (+)-hapalindole Q and (+)-12-epi-fischerindole U isothiocyanate have been described. Key steps of our approach feature expedient, highly regio- and diastereoselective Lewis acid catalyzed Friedel-Crafts reaction of indole with cyclic allylic alcohols and intramolecular reductive Heck reaction. Efficiency of the synthetic route also relies on an alkynyl aluminate complex driven regioselective nucleophilic epoxide opening from sterically hindered site...
April 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29656337/preparation-and-characterization-of-sulfonated-chitosan-modified-gold-nanoparticles-and-their-surface-electronic-payload-of-charged-drugs
#18
Huaisong Wang, Jia He, Ya Ding, Xinghua Xia
Chitosan (CS), a kind of naturally produced polysaccharide with extraordinary biocompatibility and biodegradation, shows much potential to act as reducing and stabilizing agent in the synthesis of gold nanoparticles (AuNPs) for drug delivery. To solve the poor solubility and expand the pharmaceutical applications of CS, various CS derivatives through rational design have been developed and further used to prepare, stabilize, and mediate self-assembling of gold materials. Herein, we chose sulfonic chitosan as a stabilizing reagent for the synthesis of highly stable AuNPs (AuNP/SCSs) with diameters of about 3 nm...
April 1, 2018: Science China. Life Sciences
https://www.readbyqxmd.com/read/29652439/evaluation-of-gaseous-allyl-isothiocyanate-against-the-growth-of-mycotoxigenic-fungi-and-mycotoxin-production-in-corn-stored-for-6-months
#19
Tiago M Nazareth, Jessica A F Corrêa, Anne C S M Pinto, Juliano B Palma, Giuseppe Meca, Keliani Bordin, Fernando B Luciano
BACKGROUND: Brazil produce approximately 63 million tons of corn kernels annually, which is commonly contaminated with fungi and mycotoxins. The objective of this study was to evaluate the efficacy of gaseous allyl isothiocyanate (AITC) to inhibit the growth of Aspergillus parasiticus and Fusarium verticillioides, and mycotoxin production (aflatoxins B1 , B2 , G1 and G2 , fumonisins B1 and B2 ) in corn during 180 d of storage. RESULTS: AITC at 50 μL L-1 resulted in a significant reduction of the fungal population (p <0...
April 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29651207/protective-effect-of-allyl-isothiocyanate-on-glycoprotein-components-in-7-12-dimethylbenz-a-anthracene-induced-mammary-carcinoma-in-rats
#20
Thangarasu Rajakumar, Pachaiappan Pugalendhi, Subbaiyan Thilagavathi
The present study aimed to investigate the protective effect of allyl isothiocyanate (AITC) on glycoprotein components in 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Sprague-Dawley rats. Mammary tumor was induced by a single dose of DMBA (25 mg/rat) injected subcutaneously near mammary gland. The levels of glycoprotein components such as hexose, hexosamine and sialic acid were analyzed colorimetrically in plasma, mammary and liver tissues. We observed an increased levels of glycoprotein components in plasma, mammary and liver tissues in cancer bearing rats...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
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