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Distributed cognition

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https://www.readbyqxmd.com/read/28925989/development-of-a-symptom-focused-patient-reported-outcome-measure-for-functional-dyspepsia-the-functional-dyspepsia-symptom-diary-fdsd
#1
Fiona Taylor, Sophie Higgins, Robyn T Carson, Sonya Eremenco, Catherine Foley, Brian E Lacy, Henry P Parkman, David S Reasner, Alan L Shields, Jan Tack, Nicholas J Talley
OBJECTIVES: The Functional Dyspepsia Symptom Diary (FDSD) was developed to address the lack of symptom-focused, patient-reported outcome (PRO) measures designed for use in functional dyspepsia (FD) patients and meeting Food and Drug Administration recommendations for PRO instrument development. METHODS: Concept elicitation interviews were conducted with FD participants to identify symptoms important and relevant to FD patients. A preliminary version of the FDSD was constructed, then completed by FD participants on an electronic device in cognitive interviews to evaluate the readability, comprehensibility, relevance, and comprehensiveness of the FDSD, and to preliminarily evaluate its measurement properties...
September 19, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28921526/parsing-heterogeneity-in-attention-deficit-hyperactivity-disorder-using-eeg-based-subgroups
#2
Sandra K Loo, James J McGough, James T McCracken, Susan L Smalley
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a heterogeneous condition for which multiple efforts to characterize brain state differences are underway. The objective of this study was to identify distinct subgroups of resting electroencephalography (EEG) profiles among children with and without ADHD and subsequently provide extensive clinical characterization of the subgroups. METHODS: Latent class analysis was used with resting state EEG recorded from a large sample of 781 children with and without ADHD (N = 620 ADHD, N = 161 Control), aged 6-18 years old...
September 18, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28919407/how-to-target-inter-regional-phase-synchronization-with-dual-site-transcranial-alternating-current-stimulation
#3
Guilherme Bicalho Saturnino, Kristoffer Hougaard Madsen, Hartwig Roman Siebner, Axel Thielscher
Large-scale synchronization of neural oscillations is a key mechanism for functional information exchange among brain areas. Dual-site Transcranial Alternating Current Stimulation (ds-TACS) has been recently introduced as non-invasive technique to manipulate the temporal phase relationship of local oscillations in two connected cortical areas. While the frequency of ds-TACS is matched, the phase of stimulation is either identical (in-phase stimulation) or opposite (anti-phase stimulation) in the two cortical target areas...
September 14, 2017: NeuroImage
https://www.readbyqxmd.com/read/28917017/physiological-ripples-%C3%A2-%C3%A2-100%C3%A2-hz-in-spike-free-scalp-eegs-of-children-with-and-without-epilepsy
#4
Anne H Mooij, Renee C M A Raijmann, Floor E Jansen, Kees P J Braun, Maeike Zijlmans
Pathological high frequency oscillations (HFOs, >80 Hz) are considered new biomarkers for epilepsy. They have mostly been recorded invasively, but pathological ripples (80-250 Hz) can also be found in scalp EEGs with frequent epileptiform spikes. Physiological HFOs also exist. They have been recorded invasively in hippocampus and neocortex. There are no reports of spontaneously occurring physiological HFOs recorded with scalp EEG. We aimed to study ripples in spike-free scalp EEGs. We included 23 children (6 with, 17 without epilepsy) who had an EEG without interictal epileptiform spikes recorded during sleep...
September 15, 2017: Brain Topography
https://www.readbyqxmd.com/read/28914803/achieving-congestion-mitigation-using-distributed-power-control-for-spectrum-sensor-nodes-in-sensor-network-aided-cognitive-radio-ad-hoc-networks
#5
Long Zhang, Haitao Xu, Fan Zhuo, Hucai Duan
The data sequence of spectrum sensing results injected from dedicated spectrum sensor nodes (SSNs) and the data traffic from upstream secondary users (SUs) lead to unpredictable data loads in a sensor network-aided cognitive radio ad hoc network (SN-CRN). As a result, network congestion may occur at a SU acting as fusion center when the offered data load exceeds its available capacity, which degrades network performance. In this paper, we present an effective approach to mitigate congestion of bottlenecked SUs via a proposed distributed power control framework for SSNs over a rectangular grid based SN-CRN, aiming to balance resource load and avoid excessive congestion...
September 15, 2017: Sensors
https://www.readbyqxmd.com/read/28913897/studying-the-progression-of-amyloid-pathology-and-its-therapy-using-translational-longitudinal-model-of-accumulation-and-distribution-of-amyloid-beta
#6
Tatiana Karelina, O Demin, Oleg Demin, Sridhar Duvvuri, Timothy Nicholas
Long term effects of amyloid targeted therapy can be studied using a mechanistic translational model of Aβ distribution and aggregation calibrated on published data in mouse and human species. AD pathology is modelled utilizing age-dependent pathological evolution for rate constants and several variants of explicit functions for Aβ toxicity influencing cognitive outcomes (Adas-cog). Preventive Aβ targeted therapies were simulated to minimize the Aβ difference from healthy physiological levels. Therapeutic targeted simulations provided similar predictions for mouse and human...
September 15, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28912706/dynamic-neural-fields-with-intrinsic-plasticity
#7
Claudius Strub, Gregor Schöner, Florentin Wörgötter, Yulia Sandamirskaya
Dynamic neural fields (DNFs) are dynamical systems models that approximate the activity of large, homogeneous, and recurrently connected neural networks based on a mean field approach. Within dynamic field theory, the DNFs have been used as building blocks in architectures to model sensorimotor embedding of cognitive processes. Typically, the parameters of a DNF in an architecture are manually tuned in order to achieve a specific dynamic behavior (e.g., decision making, selection, or working memory) for a given input pattern...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28911965/physiological-roles-of-cns-muscarinic-receptors-gained-from-knockout-mice
#8
REVIEW
Morgane Thomsen, Gunnar Sørensen, Ditte Dencker
Because the five muscarinic acetylcholine receptor subtypes have overlapping distributions in many CNS tissues, and because ligands with a high degree of selectivity for a given subtype long remained elusive, it has been difficult to determine the physiological functions of each receptor. Genetically engineered knockout mice, in which one or more muscarinic acetylcholine receptor subtype has been inactivated, have been instrumental in identifying muscarinic receptor functions in the CNS, at the neuronal, circuit, and behavioral level...
September 11, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28893747/the-health-and-well-being-of-australia-s-future-medical-doctors-protocol-for-a-5-year-observational-cohort-study-of-medical-trainees
#9
Erin Cvejic, Gordon Parker, Samuel B Harvey, Zachery Steel, Dusan Hadzi-Pavlovic, Claire L Macnamara, Uté Vollmer-Conna
INTRODUCTION: Clinical training in the undergraduate medical course places multiple stressors on trainees, which have been held to lead to heightened distress, depression, suicide, substance misuse/abuse and poor mental health outcomes. To date, evidence for morbidity in trainees is largely derived from cross-sectional survey-based research. This limits the accuracy of estimates and the extent to which predispositional vulnerabilities (biological and/or psychological), contextual triggers and longer-term consequences can be validly identified...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28891819/factors-influencing-successful-lumbar-puncture-in-alzheimer-research
#10
Krista L Moulder, Lilah M Besser, Duane Beekly, Kaj Blennow, Walter Kukull, John C Morris
OBJECTIVE: Lumbar puncture (LP) is increasingly common in Alzheimer disease research; however, agreement to undergo LP varies. We sought to determine factors influencing LP consent at Alzheimer's Disease Centers (ADCs) in the United States. METHODS: A 3-part survey was distributed to each ADC: (1) ADC LP Experience; (2) LP Requestor Experience; and (3) Patient LP Experience (both Initial and Follow-up). In all, 64 LP Requestor, 579 Patient/Initial, and 404 Patient/Follow-up surveys were collected...
September 7, 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/28891515/a-computational-approach-towards-the-microscale-mouse-brain-connectome-from-the-mesoscale
#11
Tielin Zhang, Yi Zeng, Bo Xu
The wiring diagram of the mouse brain presents an indispensable foundation for the research on basic and applied neurobiology. It is also essential as a structural foundation for computational simulation of the brain. Different scales of the connectome give us different hints and clues to understand the functions of the nervous system and how they process information. However, compared to the macroscale and most recent mesoscale mouse brain connectome studies, there is no complete whole brain microscale connectome available because of the scalability and accuracy of automatic recognition techniques...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28890924/measuring-attitudes-towards-interprofessional-learning-testing-two-german-versions-of-the-tool-readiness-for-interprofessional-learning-scale-on-interprofessional-students-of-health-and-nursing-sciences-and-of-human-medicine
#12
Christiane Luderer, Matthias Donat, Ute Baum, Angelika Kirsten, Patrick Jahn, Dietrich Stoevesandt
Objective: In order to verify the methodological quality of two versions of a tool for measuring attitudes towards interprofessional learning, we adapted - in terms of translation and scale form - the Heidelberg Version [1] of Readiness for Interprofessional Learning Scale - RIPLS [2], a methodologically controversial tool that had been translated into German, and compared both the original and new versions. Method: Three items were reworded and the scale form altered (from five to four levels), leading to the Halle Version that was validated by means of a cognitive pretest (n=6)...
2017: GMS Journal for Medical Education
https://www.readbyqxmd.com/read/28890916/power-analysis-to-detect-treatment-effects-in-longitudinal-clinical-trials-for-alzheimer-s-disease
#13
Zhiyue Huang, Graciela Muniz-Terrera, Brian D M Tom
INTRODUCTION: Assessing cognitive and functional changes at the early stage of Alzheimer's disease (AD) and detecting treatment effects in clinical trials for early AD are challenging. METHODS: Under the assumption that transformed versions of the Mini-Mental State Examination, the Clinical Dementia Rating Scale-Sum of Boxes, and the Alzheimer's Disease Assessment Scale-Cognitive Subscale tests'/components' scores are from a multivariate linear mixed-effects model, we calculated the sample sizes required to detect treatment effects on the annual rates of change in these three components in clinical trials for participants with mild cognitive impairment...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/28890707/elsa-2016-cohort-alcohol-tobacco-and-marijuana-use-and-their-association-with-age-of-drug-use-onset-risk-perception-and-social-norms-in-argentinean-college-freshmen
#14
Angelina Pilatti, Jennifer P Read, Ricardo M Pautassi
The transition from high school to college is a high-risk stage for the initiation and escalation of substance use. Substance use and its associated risk factors have been thoroughly described in developed countries, such as the United States, but largely neglected in Argentina, a South American country with patterns of a collectivist culture. The present cross-sectional study describes the occurrence of alcohol, tobacco, and marijuana use and the association between these behaviors and the age of onset of substance use and cognitive (i...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28887599/uptake-of-av-1451-in-meningiomas
#15
Tyler J Bruinsma, Derek R Johnson, Ping Fang, Matthew Senjem, Keith A Josephs, Jennifer L Whitwell, Bradley F Boeve, Mukesh K Pandey, Kejal Kantarci, David T Jones, Prashanthi Vemuri, Melissa Murray, Jonathan Graff-Radford, Christopher G Schwarz, David S Knopman, Ronald C Petersen, Clifford R Jack, Val J Lowe
AIM: AV-1451 is an imaging agent labeled with the positron-emitting radiolabel Fluorine-18. 18F-AV-1451 binds paired helical filament tau (PHF-tau), a pathology related to Alzheimer's disease. In our study of AV-1451 uptake in the brains of cognitively normal subjects, we noted a case of a meningioma with visually significant uptake of AV-1451. OBJECTIVE: We initiated the present retrospective study to further examine cases of meningioma that underwent AV-1451 imaging...
September 8, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28887197/reduction-in-open-field-activity-in-the-absence-of-memory-deficits-in-the-app-nl-g-f-knock-in-mouse-model-of-alzheimer-s-disease
#16
Lauren S Whyte, Kim M Hemsley, Adeline A Lau, Sofia Hassiotis, Takashi Saito, Takaomi C Saido, John J Hopwood, Timothy J Sargeant
The recent development of knock-in mouse models of Alzheimer's disease provides distinct advantages over traditional transgenic mouse models that rely on over-expression of amyloid precursor protein. Two such knock-in models that have recently been widely adopted by Alzheimer's researchers are the App(NL-F) and App(NL-G-F) mice. This study aimed to further characterise the behavioural phenotype and amyloid plaque distribution of App(NL-G-F/NL-G-F) (C57BL/6J background) mice at six-months of age. An attempt to replicate a previous study that observed deficits in working memory in the Y-maze, showed no difference between App(NL-G-F/NL-G-F) and wild-type mice...
September 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28887072/minimum-clinically-important-difference-of-montreal-cognitive-assessment-in-aneurysmal-subarachnoid-hemorrhage-patients
#17
George Kwok Chu Wong, Jodhy Suk Ying Mak, Adrian Wong, Vera Zhi Yuan Zheng, Wai Sang Poon, Jill Abrigo, Vincent Chung Tong Mok
Cognitive impairment is a major factor contributing to poor functional outcome after subarachnoid hemorrhage caused by a ruptured cerebral aneurysm (aSAH). Montreal Cognitive Assessment (MoCA) has been shown to be superior to the Mini-Mental State Examination in screening for cognitive domain deficit and correlating to functional outcome in aSAH patients. The aim of the current study was to determine the Montreal Cognitive Assessment (MoCA) score change that was associated with change of health in general in an aSAH patient cohort...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885757/frequency-specific-neuromodulation-of-local-and-distant-connectivity-in-aging-and-episodic-memory-function
#18
Simon W Davis, Bruce Luber, David L K Murphy, Sarah H Lisanby, Roberto Cabeza
A growing literature has focused on the brain's ability to augment processing in local regions by recruiting distant communities of neurons in response to neural decline or insult. In particular, both younger and older adult populations recruit bilateral prefrontal cortex (PFC) as a means of compensating for increasing neural effort to maintain successful cognitive function. However, it remains unclear how local changes in neural activity affect the recruitment of this adaptive mechanism. To address this problem, we combined graph theoretical measures from functional MRI with diffusion weighted imaging and repetitive transcranial magnetic stimulation (rTMS) to resolve a central hypothesis: how do aged brains flexibly adapt to local changes in cortical activity? Specifically, we applied neuromodulation to increase or decrease local activity in a cortical region supporting successful memory encoding (left dorsolateral PFC or DLPFC) using 5 or 1 Hz rTMS, respectively...
September 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28884353/a-prospective-longitudinal-investigation-of-the-dis-continuity-of-mental-health-difficulties-between-mid-to-late-childhood-and-the-predictive-role-of-familial-factors
#19
Cliodhna O'Connor, Udo Reulbach, Blanaid Gavin, Fiona McNicholas
Understanding individual variation in the continuity of youth mental health difficulties is critical for identifying the factors that promote recovery or chronicity. This study establishes the proportion of children showing psychopathology at 9 years, whose pathology had either remitted or persisted at 13. It describes the socio-demographic and clinical profiles of these groups, and examines the factors in 9-year-olds' familial environments that predict longitudinal remission vs. persistence of psychopathology...
September 7, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28882420/age-related-differences-in-the-topological-efficiency-of-the-brain-structural-connectome-in-amnestic-mild-cognitive-impairment
#20
Tengda Zhao, Can Sheng, Qiuhui Bi, Weili Niu, Ni Shu, Ying Han
Amnestic mild cognitive impairment (aMCI) is accompanied by the accelerated cognitive decline and rapid brain degeneration with aging. However, the age-related alterations of the topological organization of the brain connectome in aMCI patients remained largely unknown. In this study, we constructed the brain structural connectome in 51 aMCI patients and 51 healthy controls by diffusion magnetic resonance imaging and deterministic tractography. The different age-related alteration patterns of the global and regional network metrics between aMCI patients and healthy controls were assessed by a linear regression model...
August 10, 2017: Neurobiology of Aging
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