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Medication in pregnancy

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https://www.readbyqxmd.com/read/28346297/exposure-to-mycophenolate-and-fatherhood
#1
Karsten Midtvedt, Stein Bergan, Anna Varberg Reisæter, Bjørn Egil Vikse, Anders Åsberg
BACKGROUND: Mycophenolic acid (MPA) is the active immunosuppressive substance in both mycophenolate mofetil and mycophenolate sodium and it is widely used after organ transplantation. In females taking MPA is teratogenic and may also influence spermatogenesis. There is a lack of knowledge regarding outcome of pregnancies fathered by males exposed to MPA. METHODS: We compared outcomes in pregnancies fathered by renal transplant males per whether they had been exposed to MPA or not at time of conception...
March 22, 2017: Transplantation
https://www.readbyqxmd.com/read/28346240/combined-oral-medroxyprogesterone-levonorgestrel-intrauterine-system-treatment-for-women-with-grade-2-stage-ia-endometrial-cancer
#2
Ji Young Hwang, Da Hee Kim, Hyo Sook Bae, Mi-La Kim, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Eunah Shin, Mi Kyoung Kim
OBJECTIVE: The aim of this study was to evaluate the oncologic and pregnancy outcomes of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment in young women with grade 2-differentiated stage IA endometrial adenocarcinoma who wish to preserve fertility. METHODS: We retrospectively reviewed the medical records of patients with grade 2 stage IA endometrial adenocarcinoma who had received fertility-sparing treatment at CHA Gangnam Medical Center between 2011 and 2015...
March 24, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28345979/assessment-and-treatment-options-for-patients-with-constipation
#3
Alison Bardsley
Constipation is a common complaint for people of all ages, with prevalence increasing with age and during pregnancy. Women are more likely to be affected than men. Severity of constipation varies from person to person; most people experience short periods of constipation during their lives, including possibly after surgery, while others have constipation as a chronic long-term condition that can significantly affect their quality of life. There are a number of factors that can contribute to developing constipation including diets low in fibre, changes in lifestyle, side effects of certain medications and low fluid intake...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345680/personal-and-occupational-risk-factors-for-carpal-tunnel-syndrome-in-meat-processing-industry-workers-in-northern-italy
#4
Matteo Riccò, Carlo Signorelli
BACKGROUND: Carpal tunnel syndrome (CTS) is a musculoskeletal condition that often impairs the fitness to work. Our aim is to retrospectively evaluate the association between physical exposures in meat processing industry in Northern Italy and the CTS, taking into account non-occupational factors. MATERIAL AND METHODS: A cross-sectional study was performed to include 434 workers (236 males, 198 females, 37.0±10.6 years old, working age: 12.6±10.8 years) from meat processing industries...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345422/predictors-of-preference-for-caesarean-delivery-among-pregnant-women-in-beijing
#5
Hongwei Zhang, Jing Wu, Jessie Norris, Li Guo, Yifei Hu
Objective To evaluate factors associated with preference for caesarean or vaginal delivery among pregnant Chinese nulliparous and parous women. Methods In this cross-sectional study, a self-administered questionnaire was used to collect information on sociodemographic characteristics, preference/reasons for delivery mode, and knowledge of delivery complications. Results Of the 450 participants, 85 (18.9%) reported a preference for caesarean section (CS) pre-partum. Compared with women who would prefer a vaginal delivery, nulliparous women who preferred CS were more likely to be: ≥35 years; have no medical insurance; have had two or more pregnancies; have access to only one source of information about birthing options; knowledge of the complications of vaginal delivery and think doctors have no right to decide the type of delivery...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28344956/maternal-serum-placental-growth-factor-and-pregnancy-associated-plasma-protein-a-measured-in-the-first-trimester-as-parameters-of-subsequent-pre-eclampsia-and-small-for-gestational-age-infants-a-prospective-observational-study
#6
Kyung Uk Sung, Jeong A Roh, Kyung Jin Eoh, Eui Hyeok Kim
OBJECTIVE: To examine the first-trimester maternal serum placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A) levels in pregnancies associated with pre-eclampsia (PE) or small-for-gestational-age (SGA) infants, and determine the predictive accuracy of PlGF and of PAPP-A for either PE or SGA infants. METHODS: This prospective, observational study included 175 pregnant women, and of these women, due to participant withdrawal or loss to follow-up, delivery data were collected from the medical records of 155 women, including 4 who had twin pregnancies...
March 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28343907/-intra-uterine-insemination-at-either-24%C3%A2-or-48hours-after-ovulation-induction-pregnancy-and-birth-rates
#7
L Haller, F Severac, C Rongieres, J Ohl, K Bettahar, I Lichtblau, O Pirello
OBJECTIVE: Comparing rates of pregnancy and childbirth between IUI at either 24 or 48hours after injection of HCG. METHODS: This is a single-center retrospective study of couples who underwent intrauterine insemination between January 2013 and December 2014 at Medical-Surgical Obstetrical Centre of Schiltigheim. Stimulation of ovulation was done by FSH or HMG, and ovulation induction by 250μg of recombinant HCG. The insemination was performed after 2 days (group D2) or the day after (group D1)...
March 24, 2017: Gynecol Obstet Fertil Senol
https://www.readbyqxmd.com/read/28343179/nulliparous-teenagers-and-preterm-birth-in-california
#8
Jonathan A Mayo, Bat Zion Shachar, David K Stevenson, Gary M Shaw
BACKGROUND: Young maternal age is one of the numerous risk factors for delivery before 37 weeks of gestation, yet the mechanisms are unclear. The purpose of the current study was to investigate the association between teenagers and the risk of preterm birth (PTB) in a large and recent cohort study. METHODS: We conducted a population-based retrospective cohort study using 2007-2011 California birth certificate records linked with hospital discharge indices and United States census data for nulliparous 13-20 year olds who gave birth to singletons...
March 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28342949/use-of-thiopurines-during-conception-and-pregnancy-not-associated-with-adverse-pregancy-outcomes-or-health-of-infants-at-1-year-in-a-prospective-study
#9
Shannon L Kanis, Alison de Lima-Karagiannis, Nanne K H de Boer, C Janneke van der Woude
BACKGROUND & AIMS: Most data on the safety of thiopurine therapy for inflammatory bowel disease (IBD) during pregnancy come from retrospective studies, making it difficult to adjust for confounding factors. We performed a prospective cohort study to determine whether thiopurine use affects pregnancy outcomes or health outcomes of children. METHODS: We performed a prospective study of all women who visited the IBD preconception outpatient clinic at our tertiary health center in The Netherlands from December 2008 through May 2016...
March 22, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28342623/mother-newborn-health-indicators-in-possible-victims-of-gender-based-violence-during-pregnancy
#10
Juan Miguel Martínez-Galiano
BACKGROUND: Pregnancy increases the risk of gender-based violence, considered an underdiagnosed public health problem. OBJECTIVE: To determine the association between the situation of possible gender-based violence in the pregnant woman and variables related to pregnancy, labor, puerperium, and newborn health. DESIGN: An observational multicenter study. SETTINGS: Three Spanish hospitals during 2015. PARTICIPANTS: 141 pregnant women in which information is collected sociodemographic variables and data related to pregnancy, labor, and puerperium were gathered by interview and from clinical records...
April 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28342231/exploring-the-hypothesis-of-differential-care-for-african-immigrant-and-native-women-in-france-with-hypertensive-disorders-during-pregnancy-a-qualitative-study
#11
Priscille Sauvegrain, Elie Azria, Coralie Chiesa-Dubruille, Catherine Deneux-Tharaux
OBJECTIVE: To analyse whether prenatal care trajectories among women with hypertensive disorders during pregnancy in France differ between immigrants from sub-Saharan Africa (SSA) and native French women. DESIGN: Qualitative interview study. SETTING: Three public maternity units in the Paris region. POPULATION: Women born in SSA or in France of French parents and treated for hypertension or preeclampsia during their pregnancy...
March 25, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28340831/pregnancy-and-delivery-in-the-sequel-of-kidney-transplantation-single-center-study-of-8-years-experience
#12
Y Yuksel, S Tekin, D Yuksel, I Duman, M Sarier, L Yucetin, E Turan, H Celep, T Ugurlu, M M Inal, Y H Asuman, A Demirbas
BACKGROUND: Depending on hyphothalamic, hyphophyseal, and gonadal axis dysfunction, anovulatory irregular cycles occur and the probability of pregnancy decreases in the patients with chronic kidney disease (CKD). Maternal mortality and morbidity rates are increased in CKD patients; the risk of premature delivery is 70% and the risk of preeclampsia is 40% more than normal among those with a creatine level of >2.5 mg/dL. METHODS: If a pregnancy is expected in the sequel of kidney transplantation (KT), a multidisciplinary team approach should be adopted and both the gynecologist and the nephrologist should follow the patient simultaneously...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28339500/detecting-congenital-malformations-lessons-learned-from-the-mpepu-study-botswana
#13
Gbolahan Ajibola, Rebecca Zash, Roger L Shapiro, Oganne Batlang, Kerapetse Botebele, Kara Bennett, Florence Chilisa, Erik von Widenfelt, Joseph Makhema, Shahin Lockman, Lewis B Holmes, Kathleen M Powis
INTRODUCTION: A large and increasing number of HIV-infected women are conceiving on antiretroviral treatment (ART). While most antiretrovirals are considered safe in pregnancy, monitoring for rare pregnancy and infant adverse outcomes is warranted. METHODS: We conducted a retrospective secondary analysis nested within a clinical trial of infant cotrimoxazole vs. placebo prophylaxis in Botswana (the Mpepu Study). Infants were examined at birth, and at least every 3 months through 18 months of age...
2017: PloS One
https://www.readbyqxmd.com/read/28338750/association-of-maternal-plasma-folate-and-cardiometabolic-risk-factors-in-pregnancy-with-elevated-blood-pressure-of-offspring-in-childhood
#14
Hongjian Wang, Noel T Mueller, Jianping Li, Ninglin Sun, Yong Huo, Fazheng Ren, Xiaobin Wang
BACKGROUND: The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), on child systolic BP (SBP) has not been examined in a prospective birth cohort. We hypothesize that adequate maternal folate levels can reduce the risk of elevated SBP in children born to mothers with cardiometabolic risk factors...
March 6, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28338666/the-association-of-maternal-factors-with-epibulbar-dermoid-of-newborn-a-retrospective-matched-case-control-study
#15
S Wu, Y Fan, D Wu, J Hong, J Xu
PurposeTo determine the association of maternal factors and exposure during pregnancy with the incidence in newborns of epibulbar dermoid (ED), a congenital ocular surface benign tumor.Patients and methodsThis is a retrospective, paired case-control study in which 121 children with ED (case group) and 121 children without ED (control group) were recruited. Questionnaire-based interviews with mothers of participants were performed and maternal medical records during pregnancy were reviewed. The questionnaire investigated basic information, personal history, environmental exposure, exposure to maternal diseases, symptoms and corresponding medical treatments during pregnancy, and parental socioeconomic status...
March 24, 2017: Eye
https://www.readbyqxmd.com/read/28338486/congenital-cytomegalovirus-infection-management-update
#16
Asma Khalil, Chrissie Jones, Yves Ville
PURPOSE OF REVIEW: Until recently, management options in congenital cytomegalovirus (cCMV) infection have been either conservative or termination of pregnancy. However, medical therapies aimed at reducing the risk of infection and/or its severity have recently been investigated. RECENT FINDINGS: In a phase 2 open label, nonrandomized trial, valaciclovir (ValACV) was given to women carrying a CMV-infected fetus. ValACV was associated with a greater proportion of asymptomatic neonates when compared with a historical cohort (82 vs...
March 23, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28338393/contraception-for-women-with-multiple-sclerosis-guidance-for-healthcare-providers
#17
Maria K Houtchens, Lauren B Zapata, Kathryn M Curtis, Maura K Whiteman
Family planning is essential for any comprehensive treatment plan for women of reproductive age with multiple sclerosis (MS), including counseling on using effective contraception to optimally time desired and prevent unintended pregnancies. This topical review summarizes the first evidence-based recommendations on contraception safety for women with MS. In 2016, evidence-based recommendations for contraceptive use by women with MS were included in US Medical Eligibility Criteria for Contraceptive Use. They were developed after review of published scientific evidence on contraception safety and consultation with experts...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28338027/molar-incisor-hypomineralisation
#18
Greig D Taylor
Data sourcesThe Medline and Embase databases and hand searches in the journals International Journal of Paediatric Dentistry and European Archives of Paediatric Dentistry.Study selectionEnglish language cohort and case-control studies.Data extraction and synthesisStudy selection was carried out independently by two reviewers with data abstraction being conducted by a single reviewer and checked by a second reviewer. Risk of bias was assessed using a modified version of the Newcastle-Ottawa Scale (NOS). Adjusted (aOR) and unadjusted odds ratios (uOR), P-values and 95% confidence intervals (CI) were obtained from the studies...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28337037/the-diagnostic-performance-of-ultrasound-in-the-detection-of-ectopic-pregnancy
#19
Lee Young, Cecilia Barnard, Elisabeth Lewis, Matthew Jones, Jana Furlan, Angela Karatasiou, Martin Necas
BACKGROUND: Accurate diagnosis of ectopic pregnancy is essential in reducing maternal mortality and morbidity. Transvaginal ultrasound (TVUS) is the accepted imaging modality of choice for the diagnosis of ectopic pregnancy (EP). AIMS: To assess the effectiveness of transvaginal ultrasound (TVUS) in the detection of EP in consecutive women presenting for ultrasound to a radiology department with a clinical suspicion of EP. METHODS: Retrospective analysis of 585 women presenting for TVUS over a 2...
March 24, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28336173/effects-of-artesunate-on-some-biochemical-parameters-in-pregnant-albino-wistar-rats-challenged-with-lethal-strain-plasmodium-berghei-nk65-appreciating-the-activities-of-artemisinin-drugs-on-key-pregnancy-hormone-balance
#20
Chinaka O Nwaehujor, Onyeka V Asuzu, Daniel D Nwibo, Obichukwu C Nwobi, Ihechiluru I Ezeigbo
In humans, malaria in pregnancy can cause serious maternal and foetal morbidity and in extreme untreated cases, foetal mortality occurs. The therapeutic approach to curbing this malaise is the administration of an effective and/or combinations of anti-malaria medicaments. Acute or chronic administration of some of these drugs, however, gives rise to some adverse medical conditions including reproductive dysfunction, especially in pregnancy. Studies aimed at the hormonal interplays following administration of these drugs in pregnancy have been limited due to too few appropriate animal models...
March 20, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
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