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https://www.readbyqxmd.com/read/29346537/cerebral-mitochondrial-dysfunction-associated-with-deep-hypothermic-circulatory-arrest-in-neonatal-swine
#1
Constantine D Mavroudis, Michael Karlsson, Tiffany Ko, Marco Hefti, Javier I Gentile, Ryan W Morgan, Ross Plyler, Kobina G Mensah-Brown, Timothy W Boorady, Richard W Melchior, Tami M Rosenthal, Brandon C Shade, Kellie L Schiavo, Susan C Nicolson, Thomas L Spray, Robert M Sutton, Robert A Berg, Daniel J Licht, J William Gaynor, Todd J Kilbaugh
OBJECTIVES: Controversy remains regarding the use of deep hypothermic circulatory arrest (DHCA) in neonatal cardiac surgery. Alterations in cerebral mitochondrial bioenergetics are thought to contribute to ischaemia-reperfusion injury in DHCA. The purpose of this study was to compare cerebral mitochondrial bioenergetics for DHCA with deep hypothermic continuous perfusion using a neonatal swine model. METHODS: Twenty-four piglets (mean weight 3.8 kg) were placed on cardiopulmonary bypass (CPB): 10 underwent 40-min DHCA, following cooling to 18°C, 10 underwent 40 min DHCA and 10 remained at deep hypothermia for 40 min; animals were subsequently rewarmed to normothermia...
January 15, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29346377/assessing-the-feasibility-of-interrupting-the-transmission-of-soil-transmitted-helminths-through-mass-drug-administration-the-deworm3-cluster-randomized-trial-protocol
#2
Kristjana Hrönn Ásbjörnsdóttir, Sitara S Rao Ajjampur, Roy M Anderson, Robin Bailey, Iain Gardiner, Katherine E Halliday, Moudachirou Ibikounle, Khumbo Kalua, Gagandeep Kang, D Timothy J Littlewood, Adrian J F Luty, Arianna Rubin Means, William Oswald, Rachel L Pullan, Rajiv Sarkar, Fabian Schär, Adam Szpiro, James E Truscott, Marleen Werkman, Elodie Yard, Judd L Walson
ClinicalTrials.gov NCT03014167.
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29343741/species-distribution-modelling-contrasting-presence-only-models-with-plot-abundance-data
#3
Vitor H F Gomes, Stéphanie D IJff, Niels Raes, Iêda Leão Amaral, Rafael P Salomão, Luiz de Souza Coelho, Francisca Dionízia de Almeida Matos, Carolina V Castilho, Diogenes de Andrade Lima Filho, Dairon Cárdenas López, Juan Ernesto Guevara, William E Magnusson, Oliver L Phillips, Florian Wittmann, Marcelo de Jesus Veiga Carim, Maria Pires Martins, Mariana Victória Irume, Daniel Sabatier, Jean-François Molino, Olaf S Bánki, José Renan da Silva Guimarães, Nigel C A Pitman, Maria Teresa Fernandez Piedade, Abel Monteagudo Mendoza, Bruno Garcia Luize, Eduardo Martins Venticinque, Evlyn Márcia Moraes de Leão Novo, Percy Núñez Vargas, Thiago Sanna Freire Silva, Angelo Gilberto Manzatto, John Terborgh, Neidiane Farias Costa Reis, Juan Carlos Montero, Katia Regina Casula, Beatriz S Marimon, Ben-Hur Marimon, Euridice N Honorio Coronado, Ted R Feldpausch, Alvaro Duque, Charles Eugene Zartman, Nicolás Castaño Arboleda, Timothy J Killeen, Bonifacio Mostacedo, Rodolfo Vasquez, Jochen Schöngart, Rafael L Assis, Marcelo Brilhante Medeiros, Marcelo Fragomeni Simon, Ana Andrade, William F Laurance, José Luís Camargo, Layon O Demarchi, Susan G W Laurance, Emanuelle de Sousa Farias, Henrique Eduardo Mendonça Nascimento, Juan David Cardenas Revilla, Adriano Quaresma, Flavia R C Costa, Ima Célia Guimarães Vieira, Bruno Barçante Ladvocat Cintra, Hernán Castellanos, Roel Brienen, Pablo R Stevenson, Yuri Feitosa, Joost F Duivenvoorden, Gerardo A Aymard C, Hugo F Mogollón, Natalia Targhetta, James A Comiskey, Alberto Vicentini, Aline Lopes, Gabriel Damasco, Nállarett Dávila, Roosevelt García-Villacorta, Carolina Levis, Juliana Schietti, Priscila Souza, Thaise Emilio, Alfonso Alonso, David Neill, Francisco Dallmeier, Leandro Valle Ferreira, Alejandro Araujo-Murakami, Daniel Praia, Dário Dantas do Amaral, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Kenneth Feeley, Luzmila Arroyo, Marcelo Petratti Pansonato, Rogerio Gribel, Boris Villa, Juan Carlos Licona, Paul V A Fine, Carlos Cerón, Chris Baraloto, Eliana M Jimenez, Juliana Stropp, Julien Engel, Marcos Silveira, Maria Cristina Peñuela Mora, Pascal Petronelli, Paul Maas, Raquel Thomas-Caesar, Terry W Henkel, Doug Daly, Marcos Ríos Paredes, Tim R Baker, Alfredo Fuentes, Carlos A Peres, Jerome Chave, Jose Luis Marcelo Pena, Kyle G Dexter, Miles R Silman, Peter Møller Jørgensen, Toby Pennington, Anthony Di Fiore, Fernando Cornejo Valverde, Juan Fernando Phillips, Gonzalo Rivas-Torres, Patricio von Hildebrand, Tinde R van Andel, Ademir R Ruschel, Adriana Prieto, Agustín Rudas, Bruce Hoffman, César I A Vela, Edelcilio Marques Barbosa, Egleé L Zent, George Pepe Gallardo Gonzales, Hilda Paulette Dávila Doza, Ires Paula de Andrade Miranda, Jean-Louis Guillaumet, Linder Felipe Mozombite Pinto, Luiz Carlos de Matos Bonates, Natalino Silva, Ricardo Zárate Gómez, Stanford Zent, Therany Gonzales, Vincent A Vos, Yadvinder Malhi, Alexandre A Oliveira, Angela Cano, Bianca Weiss Albuquerque, Corine Vriesendorp, Diego Felipe Correa, Emilio Vilanova Torre, Geertje van der Heijden, Hirma Ramirez-Angulo, José Ferreira Ramos, Kenneth R Young, Maira Rocha, Marcelo Trindade Nascimento, Maria Natalia Umaña Medina, Milton Tirado, Ophelia Wang, Rodrigo Sierra, Armando Torres-Lezama, Casimiro Mendoza, Cid Ferreira, Cláudia Baider, Daniel Villarroel, Henrik Balslev, Italo Mesones, Ligia Estela Urrego Giraldo, Luisa Fernanda Casas, Manuel Augusto Ahuite Reategui, Reynaldo Linares-Palomino, Roderick Zagt, Sasha Cárdenas, William Farfan-Rios, Adeilza Felipe Sampaio, Daniela Pauletto, Elvis H Valderrama Sandoval, Freddy Ramirez Arevalo, Isau Huamantupa-Chuquimaco, Karina Garcia-Cabrera, Lionel Hernandez, Luis Valenzuela Gamarra, Miguel N Alexiades, Susamar Pansini, Walter Palacios Cuenca, William Milliken, Joana Ricardo, Gabriela Lopez-Gonzalez, Edwin Pos, Hans Ter Steege
Species distribution models (SDMs) are widely used in ecology and conservation. Presence-only SDMs such as MaxEnt frequently use natural history collections (NHCs) as occurrence data, given their huge numbers and accessibility. NHCs are often spatially biased which may generate inaccuracies in SDMs. Here, we test how the distribution of NHCs and MaxEnt predictions relates to a spatial abundance model, based on a large plot dataset for Amazonian tree species, using inverse distance weighting (IDW). We also propose a new pipeline to deal with inconsistencies in NHCs and to limit the area of occupancy of the species...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343545/tolloid-cleavage-activates-latent-gdf8-by-priming-the-pro-complex-for-dissociation
#4
Viet Q Le, Roxana E Iacob, Yuan Tian, William McConaughy, Justin Jackson, Yang Su, Bo Zhao, John R Engen, Michelle Pirruccello-Straub, Timothy A Springer
Growth differentiation factor 8 (GDF8)/myostatin is a latent TGF-β family member that potently inhibits skeletal muscle growth. Here, we compared the conformation and dynamics of precursor, latent, and Tolloid-cleaved GDF8 pro-complexes to understand structural mechanisms underlying latency and activation of GDF8. Negative stain electron microscopy (EM) of precursor and latent pro-complexes reveals a V-shaped conformation that is unaltered by furin cleavage and sharply contrasts with the ring-like, cross-armed conformation of latent TGF-β1...
January 17, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29340590/efficacy-and-safety-of-deep-brain-stimulation-in-tourette-syndrome-the-international-tourette-syndrome-deep-brain-stimulation-public-database-and-registry
#5
Daniel Martinez-Ramirez, Joohi Jimenez-Shahed, James Frederick Leckman, Mauro Porta, Domenico Servello, Fan-Gang Meng, Jens Kuhn, Daniel Huys, Juan Carlos Baldermann, Thomas Foltynie, Marwan I Hariz, Eileen M Joyce, Ludvic Zrinzo, Zinovia Kefalopoulou, Peter Silburn, Terry Coyne, Alon Y Mogilner, Michael H Pourfar, Suketu M Khandhar, Man Auyeung, Jill Louise Ostrem, Veerle Visser-Vandewalle, Marie-Laure Welter, Luc Mallet, Carine Karachi, Jean Luc Houeto, Bryan Timothy Klassen, Linda Ackermans, Takanobu Kaido, Yasin Temel, Robert E Gross, Harrison C Walker, Andres M Lozano, Benjamin L Walter, Zoltan Mari, William S Anderson, Barbara Kelly Changizi, Elena Moro, Sarah Elizabeth Zauber, Lauren E Schrock, Jian-Guo Zhang, Wei Hu, Kyle Rizer, Erin H Monari, Kelly D Foote, Irene A Malaty, Wissam Deeb, Aysegul Gunduz, Michael S Okun
Importance: Collective evidence has strongly suggested that deep brain stimulation (DBS) is a promising therapy for Tourette syndrome. Objective: To assess the efficacy and safety of DBS in a multinational cohort of patients with Tourette syndrome. Design, Setting, and Participants: The prospective International Deep Brain Stimulation Database and Registry included 185 patients with medically refractory Tourette syndrome who underwent DBS implantation from January 1, 2012, to December 31, 2016, at 31 institutions in 10 countries worldwide...
January 16, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29338883/epidemiology-and-risk-factors-for-chronic-thromboembolic-pulmonary-hypertension
#6
Timothy Fernandes, William Auger, Peter Fedullo
No abstract text is available yet for this article.
January 8, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29334165/3d-printing-of-liquid-crystal-elastomeric-actuators-with-spatially-programed-nematic-order
#7
Arda Kotikian, Ryan L Truby, John William Boley, Timothy J White, Jennifer A Lewis
Liquid crystal elastomers (LCEs) are soft materials capable of large, reversible shape changes, which may find potential application as artificial muscles, soft robots, and dynamic functional architectures. Here, the design and additive manufacturing of LCE actuators (LCEAs) with spatially programed nematic order that exhibit large, reversible, and repeatable contraction with high specific work capacity are reported. First, a photopolymerizable, solvent-free, main-chain LCE ink is created via aza-Michael addition with the appropriate viscoelastic properties for 3D printing...
January 15, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29330478/interaction-of-suppressor-of-cytokine-signalling-3-with-cavin-1-links-socs3-function-and-cavin-1-stability
#8
Jamie J L Williams, Nasser Alotaiq, William Mullen, Richard Burchmore, Libin Liu, George S Baillie, Fred Schaper, Paul F Pilch, Timothy M Palmer
Effective suppression of JAK-STAT signalling by the inducible inhibitor "suppressor of cytokine signalling 3" (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally significant SOCS3-interacting protein. Biochemical and confocal imaging demonstrate that SOCS3 localisation to the plasma membrane requires cavin-1. SOCS3 is also critical for cavin-1 stabilisation, such that deletion of SOCS3 reduces the expression of cavin-1 and caveolin-1 proteins, thereby reducing caveola abundance in endothelial cells...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29318628/the-international-wao-eaaci-guideline-for-the-management-of-hereditary-angioedema-the-2017-revision-and-update
#9
Marcus Maurer, Markus Magerl, Ignacio Ansotegui, Emel Aygören Pürsün, Stephen Betschel, Konrad Bork, Tom Bowen, Henrik Balle Boysen, Henriette Farkas, Anete Grumach, Michihiro Hide, Constance Katelaris, Richard Lockey, Hilary Longhurst, William Lumry, Inmaculada Martinez-Saguer, Dumitru Moldovan, Alexander Nast, Ruby Pawankar, Paul Potter, Marc Riedl, Bruce Ritchie, Lanny Rosenwasser, Mario Sánchez-Borges, Yuxiang Zhi, Bruce Zuraw, Timothy Craig
Hereditary angioedema (HAE) is a rare disease and a serious health problem, globally and for affected patients and their families. The pathophysiological background is primarily a vascular reaction to an overshooting local production of bradykinin. Evidence-based recommendations are needed to inform and guide clinical decision makers. This is the first revision and update of the global guideline for the diagnosis and management of HAE[5]. It was developed by the World Allergy Organization (WAO) in collaboration with the European Academy of Allergy and Clinical Immunology (EAACI)...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29316597/radiographic-classification-systems-for-osteonecrosis-of-the-knee-a-review-of-literature
#10
Assem A Sultan, William A Cantrell, Morad Chughtai, Prem N Ramkumar, Anton Khlopas, Jared M Newman, Nipun Sodhi, Suela Lamaj, Timothy C Wagner, Linsen T Samuel, Michael A Mont
Knee osteonecrosis is a rare, yet debilitating disease that can lead to knee joint destruction and can be associated with significant pain and disability. Various imaging modalities have different roles in the diagnosis, staging, management, and determination of the prognosis in knee osteonecrosis. Plain radiographic images can show gross joint destruction and secondary arthritic changes. In addition, magnetic resonance imaging (MRI) has become the gold-standard imaging modality to diagnose osteonecrosis. Multiple classification systems have been developed for knee osteonecrosis based on these imaging modalities...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29314903/national-athletic-trainers-association-position-statement-prevention-of-anterior-cruciate-ligament-injury
#11
Darin A Padua, Lindsay J DiStefano, Timothy E Hewett, William E Garrett, Stephen W Marshall, Grace M Golden, Sandra J Shultz, Susan M Sigward
OBJECTIVE:   To provide certified athletic trainers, physicians, and other health care and fitness professionals with recommendations based on current evidence regarding the prevention of noncontact and indirect-contact anterior cruciate ligament (ACL) injuries in athletes and physically active individuals. BACKGROUND:   Preventing ACL injuries during sport and physical activity may dramatically decrease medical costs and long-term disability. Implementing ACL injury-prevention training programs may improve an individual's neuromuscular control and lower extremity biomechanics and thereby reduce the risk of injury...
January 9, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29310656/comparative-evaluation-of-anopheline-sampling-methods-in-three-localities-in-indonesia
#12
Brandyce St Laurent, Supratman Sukowati, Timothy A Burton, David Bretz, Mulyadi Zio, Syah Firman, Sumardi, Heru Sudibyo, Amalia Safitri, Suwito, Puji B Asih, Sully Kosasih, Shinta, William A Hawley, Thomas R Burkot, Frank H Collins, Din Syafruddin, Neil F Lobo
BACKGROUND: The effectiveness of vector control efforts can vary based on the interventions used and local mosquito behaviour and adaptability. In many settings, biting patterns of Anopheles mosquitoes can shift in response to interventions targeting indoor-biting mosquitoes, often resulting in higher proportions of mosquitoes feeding outside or at times when people are not protected. These behaviourally resistant mosquitoes have been shown to sustain residual malaria transmission and limit control efforts...
January 8, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29304378/life-course-genome-wide-association-study-meta-analysis-of-total-body-bmd-and-assessment-of-age-specific-effects
#13
Carolina Medina-Gomez, John P Kemp, Katerina Trajanoska, Jian'an Luan, Alessandra Chesi, Tarunveer S Ahluwalia, Dennis O Mook-Kanamori, Annelies Ham, Fernando P Hartwig, Daniel S Evans, Raimo Joro, Ivana Nedeljkovic, Hou-Feng Zheng, Kun Zhu, Mustafa Atalay, Ching-Ti Liu, Maria Nethander, Linda Broer, Gudmar Porleifsson, Benjamin H Mullin, Samuel K Handelman, Mike A Nalls, Leon E Jessen, Denise H M Heppe, J Brent Richards, Carol Wang, Bo Chawes, Katharina E Schraut, Najaf Amin, Nick Wareham, David Karasik, Nathalie Van der Velde, M Arfan Ikram, Babette S Zemel, Yanhua Zhou, Christian J Carlsson, Yongmei Liu, Fiona E McGuigan, Cindy G Boer, Klaus Bønnelykke, Stuart H Ralston, John A Robbins, John P Walsh, M Carola Zillikens, Claudia Langenberg, Ruifang Li-Gao, Frances M K Williams, Tamara B Harris, Kristina Akesson, Rebecca D Jackson, Gunnar Sigurdsson, Martin den Heijer, Bram C J van der Eerden, Jeroen van de Peppel, Timothy D Spector, Craig Pennell, Bernardo L Horta, Janine F Felix, Jing Hua Zhao, Scott G Wilson, Renée de Mutsert, Hans Bisgaard, Unnur Styrkársdóttir, Vincent W Jaddoe, Eric Orwoll, Timo A Lakka, Robert Scott, Struan F A Grant, Mattias Lorentzon, Cornelia M van Duijn, James F Wilson, Kari Stefansson, Bruce M Psaty, Douglas P Kiel, Claes Ohlsson, Evangelia Ntzani, Andre J van Wijnen, Vincenzo Forgetta, Mohsen Ghanbari, John G Logan, Graham R Williams, J H Duncan Bassett, Peter I Croucher, Evangelos Evangelou, Andre G Uitterlinden, Cheryl L Ackert-Bicknell, Jonathan H Tobias, David M Evans, Fernando Rivadeneira
Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children, total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar spine (LS) and femoral neck (FN) is used to diagnose osteoporosis. To date, genetic variants in more than 60 loci have been identified as associated with BMD. To investigate the genetic determinants of TB-BMD variation along the life course and test for age-specific effects, we performed a meta-analysis of 30 genome-wide association studies (GWASs) of TB-BMD including 66,628 individuals overall and divided across five age strata, each spanning 15 years...
January 4, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29304282/dual-allosteric-inhibition-of-shp2-phosphatase
#14
Michelle Fodor, Edmund Price, Ping Wang, Hengyu Lu, Andreea Argintaru, Zhouliang Chen, Meir Glick, Huai-Xiang Hao, Mitsunori Kato, Robert Koenig, Jonathan R LaRochelle, Gang Liu, Eric McNeill, Dyuti Majumdar, Gisele A Nishiguchi, Lawrence B Perez, Gregory Paris, Christopher M Quinn, Timothy Ramsey, Martin Sendzik, Michael David Shultz, Sarah L Williams, Travis Stams, Stephen C Blacklow, Michael G Acker, Matthew J LaMarche
SHP2 is a cytoplasmic protein tyrosine phosphatase encoded by the PTPN11 gene and is involved in cell proliferation, differentiation, and survival. Recently we reported an allosteric mechanism of inhibition that stabilizes the auto-inhibited conformation of SHP2. SHP099 (1) was identified and characterized as a moderately potent, orally bioavailable, allosteric small molecule inhibitor, which binds to a tunnel-like pocket formed by the confluence of three domains of SHP2. In this report, we describe further screening strategies that enabled the identification of a second, distinct small molecule allosteric site...
January 5, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29298774/kidney-transplantation-in-a-patient-lacking-cytosolic-phospholipase-a2-proves-renal-origins-of-urinary-pgi-m-and-tx-m
#15
Jane Mitchell, Rebecca B Knowles, Nicholas S Kirkby, Daniel M Reed, Matthew L Edin, William E White, Melissa V Chan, Hilary Longhurst, Magdi Yaqoob, Ginger L Milne, Darryl C Zeldin, Timothy D Warner
Rationale: The balance between vascular prostacyclin which is anti-thrombotic and platelet thromboxane A2 which is pro-thrombotic is fundamental to cardiovascular health. Prostacyclin and thromboxane A2 are formed following the concerted actions of cytosolic phospholipase A2 (cPLA2α) and cyclooxygenase. Urinary 2,3-dinor-6-keto PGF1α (PGI-M) and 11-dehydro-TXB2 (TX-M) have been taken as biomarkers of prostacyclin and thromboxane A2 formation with the circulation and used to explain cyclooxygenase biology and patient phenotypes, despite concerns that urinary PGI-M and TX-M originate in the kidney...
January 3, 2018: Circulation Research
https://www.readbyqxmd.com/read/29297739/measuring-a-crisis-questioning-the-use-of-naloxone-administrations-as-a-marker-for-opioid-overdoses-in-a-large-u-s-ems-system
#16
Joseph M Grover, Taibah Alabdrabalnabi, Mehul D Patel, Michael W Bachman, Timothy F Platts-Mills, Jose G Cabanas, Jefferson G Williams
OBJECTIVE: The United States is currently experiencing a public health crisis of opioid overdoses. To determine where resources may be most needed, many public health officials utilize naloxone administration by EMS as an easily-measured surrogate marker for opioid overdoses in a community. Our objective was to evaluate whether naloxone administration by EMS accurately represents EMS calls for opioid overdose. We hypothesize that naloxone administration underestimates opioid overdose...
January 3, 2018: Prehospital Emergency Care
https://www.readbyqxmd.com/read/29288568/skeletal-muscle-microvascular-and-interstitial-po2-from-rest-to-contractions
#17
Daniel M Hirai, Jesse C Craig, Trenton D Colburn, Hiroaki Eshima, Yutaka Kano, William L Sexton, Timothy I Musch, David C Poole
Oxygen pressure (PO2 ) gradients across the blood-myocyte interface are required for diffusive O2 transport thereby supporting oxidative metabolism. The greatest resistance to O2 flux into skeletal muscle is considered to reside between the erythrocyte surface and adjacent sarcolemma, although this has not been measured during contractions. We tested the hypothesis that O2 gradients between skeletal muscle microvascular (PO2 mv) and interstitial (PO2 is) spaces would be present at rest and maintained or increased during contractions...
December 30, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29284660/the-modern-resource-genome-wide-binding-profiles-for-hundreds-of-drosophila-and-caenorhabditis-elegans-transcription-factors
#18
Michelle M Kudron, Alec Victorsen, Louis Gevirtzman, LaDeana W Hillier, William W Fisher, Dionne Vafeados, Matt Kirkey, Ann S Hammonds, Jeffery Gersch, Haneen Ammouri, Martha L Wall, Jennifer Moran, David Steffen, Matt Szynkarek, Samantha Seabrook-Sturgis, Nader Jameel, Madhura Kadaba, Jaeda Patton, Robert Terrell, Mitch Corson, Timothy J Durham, Soo Park, Swapna Samanta, Mei Han, Jinrui Xu, Koon-Kiu Yan, Susan E Celniker, Kevin P White, Lijia Ma, Mark Gerstein, Valerie Reinke, Robert Waterston
In order to develop a catalog of regulatory sites in two major model organisms, Drosophilia melanogaster and Caenorhabditis elegans, the modERN consortium has systematically assayed the binding sites of transcription factors (TFs). Combined with data produced by our predecessor, modENCODE, we now have data for 262 TFs identifying 1.23M sites in the fly genome and 217 TFs identifying 0.67M sites in the worm genome. Because sites from different TFs are often overlapping and tightly clustered, they fall into 91,011 and 59,150 regions in the fly and worm, respectively, and these binding sites span as little as 8...
December 28, 2017: Genetics
https://www.readbyqxmd.com/read/29284072/adjuvant-therapy-is-associated-with-improved-survival-after-curative-resection-for-hilar-cholangiocarcinoma-a-multi-institution-analysis-from-the-u-s-extrahepatic-biliary-malignancy-consortium
#19
Bradley A Krasnick, Linda X Jin, Jesse T Davidson, Dominic E Sanford, Cecilia G Ethun, Timothy M Pawlik, George A Poultsides, Thuy Tran, Kamran Idrees, William G Hawkins, William C Chapman, Maria B M Doyle, Sharon M Weber, Steven M Strasberg, Ahmed Salem, Robert C G Martin, Chelsea A Isom, Charles Scoggins, Carl R Schmidt, Perry Shen, Eliza Beal, Ioannis Hatzaras, Rivfka Shenoy, Shishir K Maithel, Ryan C Fields
BACKGROUND: Curative-intent treatment for localized hilar cholangiocarcinoma (HC) requires surgical resection. However, the effect of adjuvant therapy (AT) on survival is unclear. We analyzed the impact of AT on overall (OS) and recurrence free survival (RFS) in patients undergoing curative resection. METHODS: We reviewed patients with resected HC between 2000 and 2015 from the ten institutions participating in the U.S. Extrahepatic Biliary Malignancy Consortium...
December 28, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29279374/evaluating-the-contribution-of-rare-variants-to-type-2-diabetes-and-related-traits-using-pedigrees
#20
Goo Jun, Alisa Manning, Marcio Almeida, Matthew Zawistowski, Andrew R Wood, Tanya M Teslovich, Christian Fuchsberger, Shuang Feng, Pablo Cingolani, Kyle J Gaulton, Thomas Dyer, Thomas W Blackwell, Han Chen, Peter S Chines, Sungkyoung Choi, Claire Churchhouse, Pierre Fontanillas, Ryan King, SungYoung Lee, Stephen E Lincoln, Vasily Trubetskoy, Mark DePristo, Tasha Fingerlin, Robert Grossman, Jason Grundstad, Alison Heath, Jayoun Kim, Young Jin Kim, Jason Laramie, Jaehoon Lee, Heng Li, Xuanyao Liu, Oren Livne, Adam E Locke, Julian Maller, Alexander Mazur, Andrew P Morris, Toni I Pollin, Derek Ragona, David Reich, Manuel A Rivas, Laura J Scott, Xueling Sim, Rick G Tearle, Yik Ying Teo, Amy L Williams, Sebastian Zöllner, Joanne E Curran, Juan Peralta, Beena Akolkar, Graeme I Bell, Noël P Burtt, Nancy J Cox, Jose C Florez, Craig L Hanis, Catherine McKeon, Karen L Mohlke, Mark Seielstad, James G Wilson, Gil Atzmon, Jennifer E Below, Josée Dupuis, Dan L Nicolae, Donna Lehman, Taesung Park, Sungho Won, Robert Sladek, David Altshuler, Mark I McCarthy, Ravindranath Duggirala, Michael Boehnke, Timothy M Frayling, Gonçalo R Abecasis, John Blangero
A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare variants to the risk of type 2 diabetes (T2D) and related traits, we performed deep whole-genome analysis of 1,034 members of 20 large Mexican-American families with high prevalence of T2D. If rare variants of large effect accounted for much of the diabetes risk in these families, our experiment was powered to detect association...
December 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
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