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JOURNAL ARTICLE
Sebastiaan Heidt, Dave L Roelen, Chantal Eijsink, Cees van Kooten, Frans H J Claas, Arend Mulder
BACKGROUND: Humoral immunity is increasingly recognized as an important factor in the rejection of organ transplants. In general, humoral rejection is treated with standard immunosuppressive drugs. The direct effect of these immunosuppressive drugs on B cells is not well known. METHODS: Purified human B cells devoid of T cells were stimulated with CD40L expressing L cells, or by anti-CD40 mAb with or without Toll-like receptor triggering, all in the presence of B-cell activating cytokines...
November 15, 2008: Transplantation
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