Tomoki Kasahara, Megumu Tanaka, Yunlu Zhao, Akiko Kamiyoshi, Takayuki Sakurai, Yuka Ichikawa-Shindo, Hisaka Kawate, Yorishige Matsuda, Yan Zhang, Qianqian Guo, Peixuan Li, Ken Hoshiyama, Jiake Li, Naho Onishi, Marina Hayashi, Hideki Sanjo, Kumiko Ishida, Satoshi Tanaka, Mikito Kawamata, Takayuki Shindo
Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition characterized by widespread inflammation and pulmonary edema. Adrenomedullin (AM), a bioactive peptide with various functions, is expected to be applied in treating ARDS. Its functions are regulated primarily by two receptor-activity-modifying proteins, RAMP2 and RAMP3, which bind to the AM receptor calcitonin-receptor-like receptor (CLR). However, the roles of RAMP2 and RAMP3 in ARDS remain unclear. We generated a mouse model of ARDS via intratracheal administration of lipopolysaccharide (LPS), and analyzed the pathophysiological significance of RAMP2 and RAMP3...
November 25, 2023: Peptides