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Adrenomedullin

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https://www.readbyqxmd.com/read/27919636/adrenomedullin-and-angiotensin-ii-signaling-pathways-involved-in-the-effects-on-cerebellar-antioxidant-enzymes-activity
#1
Figueira Leticia, Israel Anita
Human adrenomedullin (AM) is a 52-amino acid peptide involved in cardiovascular control. AM has two specific receptors formed by the calcitonin-receptor-like receptor (CRLR) and receptor activity-modifying protein (RAMP) 2 or 3, known as AM1 and AM2 receptors, respectively. In addition, AM has appreciable affinity for the calcitonin gene-1 related peptide receptor (CGRP1), composed of CRLR/RAMP1. In brain, AM and their receptors are expressed in several localized areas, including the cerebellum. AM has been reported as an antioxidant...
December 2, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/27865148/plasma-adrenomedullin-in-critically-ill-patients-with-sepsis-after-major-surgery-a-pilot-study
#2
Tim-Philipp Simon, Lukas Martin, Sabine Doemming, Andreas Humbs, Christian Bruells, Ruedger Kopp, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Gernot Marx, Tobias Schuerholz
PURPOSE: Adrenomedullin is released by different tissues in hypoxia, oxidative stress, and inflammation and is found in general and medical patients and, recently, in sepsis patients in emergency departments. The aim of this study was to evaluate biologically active adrenomedullin that mirrors directly the active peptide levels in plasma of surgical intensive care unit (ICU) patients with sepsis. MATERIALS AND METHODS: In this single-center observational pilot trial, 42 ICU patients with sepsis and 14 patients after major surgery were included after sepsis diagnosis or ICU admission...
October 28, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27860068/effect-of-osa-on-hypoxic-and-inflammatory-markers-during-cpap-withdrawal-further-evidence-from-three-randomized-control-trials
#3
Chris D Turnbull, Valentina A Rossi, Peter Santer, Esther I Schwarz, John R Stradling, Nayia Petousi, Malcolm Kohler
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) is associated with cardiovascular disease. Intermittent hypoxia, endothelial dysfunction and adipose tissue-mediated inflammation have all been linked to cardiovascular disease in OSA. We therefore explored the effect of OSA on relevant associated blood markers: adrenomedullin (ADM), endocan, endothelin-1 (ET-1), resistin and vascular endothelial growth factor (VEGF). METHODS: Patients with OSA, established on and compliant with continuous positive airways pressure (CPAP) therapy for >1 year were included from three randomized controlled trials, conducted at two centres...
November 18, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27825364/mid-regional-pro-adrenomedullin-mr-proadm-a-marker-of-positive-fluid-balance-in-critically-ill-patients-results-of-the-envol-study
#4
Bernard Vigué, Pierre-Etienne Leblanc, Frédérique Moati, Eric Pussard, Hussam Foufa, Aurore Rodrigues, Samy Figueiredo, Anatole Harrois, Jean-Xavier Mazoit, Homa Rafi, Jacques Duranteau
BACKGROUND: The optimal control of blood volume without fluid overload is a main challenge in the daily care of intensive care unit (ICU) patients. Accordingly this study focused on the identification of biomarkers to help characterize fluid overload status. METHODS: Sixty-seven patients were studied from ICU admission to day 7 (D7). Blood and urine samples were taken daily and sodium and water balance strictly calculated resulting in a total cumulative assessment of ∆Na(+) and ∆H2O...
November 9, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27807280/blood-biomarkers-associated-with-neurological-deterioration-in-patients-with-acute-penetrating-artery-territory-infarction-a-multicenter-prospective-observational-study
#5
Tomohiro Kawano, Kotaro Miyashita, Mariko Takeuchi, Yoshinari Nagakane, Yasumasa Yamamoto, Kenji Kamiyama, Yasuhiro Manabe, Kenichi Todo, Norifumi Metoki, Yasuhisa Akaiwa, Kazunori Toyoda, Kazuyuki Nagatsuka
BACKGROUND AND PURPOSE: Neurological deterioration in acute penetrating artery territory infarction is unpredictable and associated with unfavorable clinical outcomes. The aim of this prospective study was to clarify the cause of neurological worsening and predict clinical outcomes using blood biomarkers. METHODS: Eight Japanese stroke centers participated. Blood samples were obtained within 24 h (the first sampling) and on day 7 in hospital (the second sampling) in patients with penetrating artery territory infarction, arriving within two days of stroke onset...
November 2, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27805242/relationship-between-site-of-myocardial-infarction-left-ventricular-function-and-cytokine-levels-in-patients-undergoing-coronary-artery-surgery
#6
Ilker Kiris, Sahin Kapan, Cuneyt Narin, Mehmet Ozaydın, Medine Cumhur Cure, Recep Sutcu, Huseyin Okutan
BACKGROUND: The purpose of this study was to examine the relationship between left ventricular (LV) function, cytokine levels and site of myocardial infarction (MI) in patients undergoing coronary artery bypass grafting (CABG). METHODS: Sixty patients undergoing CABG were divided into three groups (n = 20) according to their history of site of myocardial infarction (MI): no previous MI, anterior MI and posterior/inferior MI. In the pre-operative period, detailed analysis of LV function was done by transthoracic echocardiography...
September 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27788390/inflammation-versus-mechanical-stretch-biomarkers-over-time-in-acutely-decompensated-heart-failure-with-reduced-ejection-fraction
#7
M Boulogne, M Sadoune, J M Launay, M Baudet, A Cohen-Solal, D Logeart
: Heart failure can be associated with inflammation but it is unclear if inflammation is directly related to hemodynamic worsening or is an independent pathway. Our aim was to investigate inflammation and mechanical stress using serial measurements of biomarkers in acute and chronic heart failure with reduced ejection fraction (AHF and CHF). METHOD: The following biomarkers were measured on admission, at discharge and one month after discharge: B-type natriuretic peptide (BNP), high-sensitivity C-Reactive protein (hsCRP), Tumour Necrosis Factor alpha (TNFα), interleukin 6 (IL6), myeloperoxidase (MPO), suppression of tumorigenicity 2 (ST2), mid-regional pro-adrenomedullin (MR-proADM), galectin 3 (Gal3), Growth differentiating factor 15 (GDF15) and procalcitonin (PCT)...
October 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27784654/calcitonin-gene-related-peptide-rescues-proximity-associations-of-its-receptor-components-calcitonin-receptor-like-receptor-and-receptor-activity-modifying-protein1-in-rat-uterine-artery-smooth-muscle-cells-exposed-to-tumor-necrosis-factor-alpha
#8
Yuanlin Dong, Madhu Chauhan, Michael Belfort, Chandra Yallampalli
Calcitonin gene-related peptide (CALCB), adrenomedullin (ADM) and adrenomedullin 2 (ADM2)/intermedin (IMD) play critical roles in vascular adaptation during pregnancy through calcitonin-receptor-like-receptor (CALCRL) and receptor activity-modifying proteins (RAMPs). This study was designed to assess the predominant RAMP that associates with CALCRL to form a functional receptor in the rat uterine artery smooth muscle (RUASM). We also determined if these receptor component associations are decreased by TNF-α and if CALCB, ADM or ADM2 can rescue CRLR/RAMP associations...
October 26, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27776076/extracellular-elevation-of-adrenomedullin-a-gene-associated-with-schizophrenia-suppresses-heat-shock-protein-1a-1b-mrna
#9
Zhilei Zhao, Seiichiro Jinde, Chihiro Kakiuchi, Kiyoto Kasai
Several recent gene expression studies on schizophrenia, including one using monozygotic twins discordant for the disease, have reported the upregulation of adrenomedullin (ADM), which was initially identified as a vasodilator hormone. It has been hypothesized that upregulation of ADM may be a susceptibility factor for schizophrenia, although the exact role of ADM in the central nervous system remains unclear. In this study, we used a microarray analysis to investigate the changes in global gene expression induced by the administration of exogenous ADM in SK-N-SH cells, which allowed us to evaluate the effects of elevated ADM on the central nervous system...
October 21, 2016: Neuroreport
https://www.readbyqxmd.com/read/27750106/breast-cancer-osteomimicry-and-its-role-in-bone-specific-metastasis-an%C3%A2-integrative-systematic-review-of-preclinical-evidence
#10
REVIEW
Olugbenga Awolaran, Susan A Brooks, Verna Lavender
Metastasis accounts for most of the deaths from breast cancer and the preference of invasive breast cancer metastasising to bone has been widely reported. However, the biological basis of breast cancer osteotropism is not fully understood. This paper provides, for the first time, an integrative, systematic review of evidence of molecular factors that have functional roles in the homing of metastatic breast cancer to the bone. Pubmed, Web of Science and EBSCOhost were searched using keywords and synonyms for molecular, metastasis, breast cancer and bone to identify articles published between January 2004 and August 2016...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27737007/calcitonin-peptide-family-members-are-differentially-regulated-by-lps-and-inhibit-functions-of-rat-alveolar-nr8383-macrophages
#11
Aichurek Soultanova, Zbigniew Mikulski, Uwe Pfeil, Veronika Grau, Wolfgang Kummer
Members of the calcitonin peptide family-calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)-exert modulatory effects upon monocytes and macrophages of various extrapulmonary origins. Utilizing the rat alveolar macrophage (AMφ) cell line NR8383, we here set out to determine to which extent these three peptides and their receptors are differentially regulated in AMφ and what specific effects they have on AMφ key functions. LPS treatment differentially up-regulated expression of the peptides and receptors...
2016: PloS One
https://www.readbyqxmd.com/read/27713887/new-role-of-biomarkers-mid-regional-pro-adrenomedullin-the-biomarker-of-organ-failure
#12
REVIEW
Francisco Valenzuela-Sánchez, Blanca Valenzuela-Méndez, Juan Francisco Rodríguez-Gutiérrez, Ángel Estella-García, María Ángela González-García
Mid-regional pro-adrenomedullin (MR-proADM) has a good biomarker profile: its half-life is several hours, and its plasma concentrations can be determined in clinical practice, it is essentially irrelevant, but proportionally represents the levels and activity of adrenomedullin (ADM). ADM synthesis is widely distributed in tissues, including bone, adrenal cortex, kidney, lung, blood vessels and heart. Its fundamental biological effects include vasodilator, positive inotropic, diuretic, natriuretic and bronchodilator...
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27665970/high-dose-irradiation-of-bone-chips-preserves-the-in-vitro-activity-of-bone-conditioned-medium
#13
Kosaku Sawada, Richard J Miron, Dominic Leiser, Jordi Caballé-Serrano, Dieter D Bosshardt, Benoit Schaller, Daniel Buser, Reinhard Gruber
Extracorporeal irradiation sterilizes resected tumor bone used as autografts in reconstruction surgery. Therapeutic irradiation is a standard technique in head and neck cancer therapy that aims to preserve organ function. Bone irradiation has a complex, mostly inhibitory, effect on remodeling and regeneration, although the underlying mechanisms are still not fully understood. It remains unclear if extracorporeal irradiation affects the paracrine-like activity of the corresponding autografts. We recently reported that bone-conditioned medium from autogenous bone chips contains a number of factors that might affect cell activity...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27640364/lack-of-adrenomedullin-in-mouse-endothelial-cells-results-in-defective-angiogenesis-enhanced-vascular-permeability-less-metastasis-and-more-brain-damage
#14
Laura Ochoa-Callejero, Andrea Pozo-Rodrigálvarez, Ricardo Martínez-Murillo, Alfredo Martínez
Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. AM plays critical roles in blood vessels, including regulation of vascular stability and permeability. To elucidate the autocrine/paracrine function of AM in endothelial cells (EC) in vivo, a conditional knockout of AM in EC (AM(EC-KO)) was used. The amount of vascularization of the matrigel implants was lower in AM(EC-KO) mice indicating a defective angiogenesis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27621315/adrenomedullin-2-enhances-beiging-in-white-adipose-tissue-directly-in-an-adipocyte-autonomous-manner-and-indirectly-through-activation-of-m2-macrophages
#15
Ying Lv, Song-Yang Zhang, Xianyi Liang, Heng Zhang, Zhi Xu, Bo Liu, Ming-Jiang Xu, Changtao Jiang, Jin Shang, Xian Wang
Adrenomedullin 2 (ADM2) is an endogenous bioactive peptide belonging to the calcitonin gene-related peptide family. Our previous studies showed that overexpression of ADM2 in mice reduced obesity and insulin resistance by increasing thermogenesis in brown adipose tissue. However, the effects of ADM2 in another type of thermogenic adipocyte, beige adipocytes, remain to be understood. The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resistance to high-fat diet-induced obesity with increased energy expenditure...
November 4, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27619517/an-intracellular-adrenomedullin-system-reduces-il-6-release-via-a-nf-kb-mediated-camp-independent-transcriptional-mechanism-in-rat-thymic-epithelial-cells
#16
Giulia Castellani, Giovanna Paliuri, Genny Orso, Nicola Paccagnella, Claudio D'Amore, Laura Facci, Francesca Cima, Federico Caicci, Pietro Palatini, Sergio Bova, Sara De Martin
Thymic epithelial cells (TECs) play a key role in the regulation of central immune tolerance by expressing autoantigens and eliminating self-reactive T cells. In a previous paper we reported that adrenomedullin (ADM) and its co-receptor protein RAMP2 are located intracellularly in newborn human thymic epithelial cells (TECs). This work has two main aims: (1) to examine the cellular localization of ADM and its receptor in TECs of adult Wistar rats to validate this animal model for the study of the ADM system and its function(s) in thymus; (2) to investigate the potential modulating effect of ADM on the NF-kB pathway, which is involved through the production of cytokines such as IL-6, in the maturation of T-lymphocytes and immunological tolerance...
December 2016: Cytokine
https://www.readbyqxmd.com/read/27614623/cerebellar-adrenomedullinergic-system-role-in-cardiovascular-regulation
#17
Leticia Figueira, Anita Israel
Adrenomedullin (AM) is a multifunctional peptide which exerts numerous biological activities through the activation of AM1 (CRLR + RAMP2) and AM2 (CRLR + RAMP3) receptors. AM immunoreactivity, AM binding sites and CRLR, RAMP1, RAMP2 and RAMP3 are expressed in rat cerebellar vermis. AM binding sites are discretely and differentially distributed in the rat cerebellar cortex with higher levels detected in SHR when compared with WKY rats. In addition, there is an up-regulation of cerebellar CGRP1 (CRLR + RAMP1) and AM2 (CRLR + RAMP3) receptors and a down-regulation of AM1 (CRLR + RAMP2) receptor during hypertension associated with a decreased AM expression...
September 11, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27609943/discovery-of-new-biomarkers-for-atrial-fibrillation-using-a-custom-made-proteomics-chip
#18
Lars Lind, Johan Sundström, Markus Stenemo, Emil Hagström, Johan Ärnlöv
BACKGROUND: Apart from several established clinical risk factors for atrial fibrillation (AF), a number of biomarkers have also been identified as potential risk factors for AF. None of these have so far been adopted in clinical practice. OBJECTIVE: To use a novel custom-made proteomics chip to discover new prognostic biomarkers for AF risk. METHODS: In two independent community-based cohorts (Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (978 participants without AF, mean age 70...
September 8, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27595128/dataset-of-the-associations-of-aldosterone-to-renin-ratio-with-mr-proanp-and-mr-proadm
#19
Cornelia Then, Marietta Rottenkolber, Andreas Lechner, Christa Meisinger, Margit Heier, Wolfgang Koenig, Annette Peters, Wolfgang Rathmann, Martin Bidlingmaier, Martin Reincke, Jochen Seissler
This article contains data related to the research article entitled "Altered relation of the renin-aldosterone system and vasoactive peptides in type 2 diabetes: the KORA F4 study" (Then et al., 2016) [1] and describes the association of the aldosterone to renin ratio with midregional-pro atrial natriuretic peptide (MR-proANP) and midregional-pro adrenomedullin (MR-proADM) in 1261 participants from the KORA F4 cohort.
September 2016: Data in Brief
https://www.readbyqxmd.com/read/27566546/receptor-activity-modifying-protein-directed-g-protein-signaling-specificity-for-the-calcitonin-gene-related-peptide-family-of-receptors
#20
Cathryn Weston, Ian Winfield, Matthew Harris, Rose Hodgson, Archna Shah, Simon J Dowell, Juan Carlos Mobarec, David A Woodlock, Christopher A Reynolds, David R Poyner, Harriet A Watkins, Graham Ladds
The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). Binding of one of the three peptide ligands, CGRP, adrenomedullin (AM), and intermedin/adrenomedullin 2 (AM2), is well known to result in a Gαs-mediated increase in cAMP. Here we used modified yeast strains that couple receptor activation to cell growth, via chimeric yeast/Gα subunits, and HEK-293 cells to characterize the effect of different RAMP and ligand combinations on this pathway...
October 14, 2016: Journal of Biological Chemistry
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