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https://www.readbyqxmd.com/read/29342941/development-of-optical-fiber-based-measurement-system-for-the-verification-of-entrance-dose-map-in-pencil-beam-scanning-proton-beam
#1
Jaeman Son, Se Byeong Lee, Youngkyung Lim, Sung Yong Park, Kwanho Cho, Myonggeun Yoon, Dongho Shin
This study describes the development of a beam monitoring system for the verification of entrance dose map in pencil beam scanning (PBS) proton therapy based on fiber optic radiation sensors (FORS) and the validation of this system through a feasibility study. The beam monitoring system consisted of 128 optical fibers optically coupled to photo-multiplier tubes. The performance of the beam monitoring system based on FORS was verified by comparing 2D dose maps of square-shaped fields of various sizes, which were obtained using conventional dosimeters such as MatriXX and EBT3 film, with those measured using FORS...
January 15, 2018: Sensors
https://www.readbyqxmd.com/read/29339570/comparison-of-monte-carlo-and-analytical-dose-computations-for-intensity-modulated-proton-therapy
#2
Pablo P Yepes, Antony H Adair, David R Grosshans, Dragan Mirkovic, Falk Poenisch, Uwe Titt, Qianxia Wang, Radhe Mohan
To evaluate the effect of approximations in clinical analytical calculations performed by a Treatment Planning System (TPS) on dosimetric indices in Intensity Modulated Proton Therapy. Methods: TPS calculated dose distributions were compared with dose distributions as estimated by Monte Carlo (MC) simulations, calculated with the Fast Dose Calculator (FDC) a system previously benchmarked to full MC. This study analyzed a total of 525 patients for four treatment sites (brain, head-and-neck, thorax and prostate)...
January 17, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29328862/what-happens-when-proton-meets-randomization-is-there-a-future-for-proton-therapy
#3
Feng-Ming Spring Kong
No abstract text is available yet for this article.
January 12, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29324441/a-study-of-lateral-fall-off-penumbra-optimisation-for-pencil-beam-scanning-pbs-proton-therapy
#4
C Winterhalter, A Lomax, D Oxley, D C Weber, S Safai
The lateral fall-off is crucial for sparing organs at risk in proton therapy. It is therefore of high importance to minimize the penumbra for pencil beam scanning (PBS). Three optimisation approaches are investigated: edge-collimated uniformly weighted spots (collimation), pencil beam optimisation of uncollimated pencil beams (edge-enhancement) and the optimisation of edge collimated pencil beams (collimated edge-enhancement). To deliver energies below 70 MeV, these strategies are evaluated in combination with the following pre-absorber methods: field specific fixed thickness pre-absorption (fixed), range specific, fixed thickness pre-absorption (automatic) and range specific, variable thickness pre-absorption (variable)...
January 11, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29316969/proton-and-helium-ion-radiotherapy-for-meningioma-tumors-a-monte-carlo-based-treatment-planning-comparison
#5
Thomas Tessonnier, Andrea Mairani, Wenjing Chen, Paola Sala, Francesco Cerutti, Alfredo Ferrari, Thomas Haberer, Jürgen Debus, Katia Parodi
BACKGROUND: Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain and ocular meningiomas with protons and helium ions, using for the first time a dedicated Monte Carlo (MC) based treatment planning engine (MCTP) thoroughly validated both in terms of physical and biological models. METHODS: Starting from clinical treatment plans of four patients undergoing proton therapy with a fixed relative biological effectiveness (RBE) of 1...
January 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29301336/clinical-implementation-of-robust-optimization-for-craniospinal-irradiation
#6
Alexandria Tasson, Nadia N Laack, Chris Beltran
With robust optimization for spot scanning proton therapy now commercially available, the ability exists to account for setup, range, and interfield uncertainties during optimization. Robust optimization is particularly beneficial for craniospinal irradiation (CSI) where the large target volume lends itself to larger setup uncertainties and the need for robust match lines can all be handled with the uncertainty parameters found inside the optimizer. Suggested robust optimization settings, parameters, and image guidance for CSI patients using proton therapy spot scanning are provided...
January 3, 2018: Cancers
https://www.readbyqxmd.com/read/29300183/improved-proton-ct-imaging-using-a-bismuth-germanium-oxide-scintillator
#7
Sodai Tanaka, Teiji Nishio, Masato Tsuneda, Keiichiro Matsushita, Shigeto Kabuki, Mitsuru Uesaka
Range uncertainty is among the most formidable challenges associated with the treatment planning of proton therapy. Proton imaging, which includes proton radiography (pRG) and proton computed tomography (pCT), is a useful verification tool. We have developed a pCT detection system that uses a thick bismuth germanium oxide (BGO) scintillator and a CCD camera. The current method is based on a previous detection system that used a plastic scintillator, and implements improved image processing techniques. In the new system, the scintillation light intensity is integrated along the proton beam path by the BGO scintillator, and acquired as a two-dimensional distribution with the CCD camera...
January 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29289170/an-isocenter-estimation-tool-for-proton-gantry-alignment
#8
Peter Hansen, Dongming Hu
A novel tool has been developed to automate the process of locating the isocenter, center of rotation, and sphere of confusion of a proton therapy gantry. The tool uses a Radian laser tracker to estimate how the coordinate frame of the front-end beam-line components changes as the gantry rotates. The coordinate frames serve as an empirical model of gantry flexing. Using this model, the alignment of the front and back-end beam-line components can be chosen to minimize the sphere of confusion, improving the overall beam positioning accuracy of the gantry...
December 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29282443/first-ever-use-of-proton-stereotactic-body-radiation-therapy-delivered-with-curative-intent-to-bilateral-synchronous-primary-renal-cell-carcinomas
#9
Melissa A Frick, Arpit M Chhabra, Liyong Lin, Charles B Simone Ii
Limited therapeutic options exist for inoperable bilateral kidney tumors. We report the first ever use of proton therapy to treat primary renal cell carcinoma (RCC) and the first report of proton stereotactic body radiation therapy (SBRT) for RCC in an inoperable patient with synchronous RCCs treated with proton SBRT. The patient is a 47-year-old 450-pound female with multiple medical comorbidities, including Stage 3 chronic kidney disease (CKD), who was found to have bilateral renal masses during work-up for cellulitis and sepsis...
October 24, 2017: Curēus
https://www.readbyqxmd.com/read/29280468/superiority-in-robustness-of-multifield-optimization-over-single-field-optimization-for-pencil-beam-proton-therapy-for-oropharynx-carcinoma-an-enhanced-robustness-analysis
#10
Kristin Stützer, Alexander Lin, Maura Kirk, Liyong Lin
PURPOSE: To compare the difference in robustness of single-field optimized (SFO) and robust multifield optimized (rMFO) proton plans for oropharynx carcinoma patients by an improved robustness analysis. METHODS AND MATERIALS: We generated rMFO proton plans for 11 patients with oropharynx carcinoma treated with SFO intensity modulated proton therapy with simultaneous integrated boost prescription. Doses from both planning approaches were compared for the initial plans and the worst cases from 20 optimization scenarios of setup errors and range uncertainties...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29280467/potential-of-proton-therapy-to-reduce-acute-hematologic-toxicity-in-concurrent-chemoradiation-therapy-for-esophageal-cancer
#11
Samantha Warren, Christopher N Hurt, Thomas Crosby, Mike Partridge, Maria A Hawkins
PURPOSE: Radiation therapy dose escalation using a simultaneous integrated boost (SIB) is predicted to improve local tumor control in esophageal cancer; however, any increase in acute hematologic toxicity (HT) could limit the predicted improvement in patient outcomes. Proton therapy has been shown to significantly reduce HT in lung cancer patients receiving concurrent chemotherapy. Therefore, we investigated the potential of bone marrow sparing with protons for esophageal tumors. METHODS AND MATERIALS: Twenty-one patients with mid-esophageal cancer who had undergone conformal radiation therapy (3D50) were selected...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29276214/new-perspective-on-the-treatment-of-intractable-gastrointestinal-cancers-role-of-combination-therapies
#12
Dan G Duda
Unresectable gastrointestinal cancers, such as gastric, hepatocellular, biliary tract or pancreatic carcinomas, are often resistant to anti-cancer systemic therapies, and often recur locally or even after aggressive local therapies leading to dismal survival rates. Recent developments in oncology, have offered renewed hoped for the development of more efficacious therapies. For example, our understanding of the oncogenic drivers in carcinogenesis has increased exponentially, and may potentially allow personalization of therapy...
2017: Keio Journal of Medicine
https://www.readbyqxmd.com/read/29248169/simultaneous-integrated-boost-for-radiation-dose-escalation-to-the-gross-tumor-volume-with-intensity-modulated-photon-radiation-therapy-or-intensity-modulated-proton-therapy-and-concurrent-chemotherapy-for-stage-ii-to-iii-non-small-cell-lung-cancer-a-phase
#13
Melenda D Jeter, Daniel Gomez, Quynh-Nhu Nguyen, Ritsuko Komaki, Xiaodong Zhang, Xiaorong Zhu, Michael O'Reilly, Frank V Fossella, Ting Xu, Xiong Wei, Hui Wang, Wenjuan Yang, Anne Tsao, Radhe Mohan, Zhongxing Liao
PURPOSE: To establish, in the phase 1 portion of a prospective phase 1/2 study, the maximum tolerated dose of image guided intensity modulated radiation therapy (IMRT) or proton therapy (IMPT), both with a simultaneous integrated boost (SIB), for patients with stage II to IIIB non-small cell lung cancer receiving concurrent chemoradiation therapy. METHODS AND MATERIALS: Patients had pathologically proven non-small cell lung cancer, either unresectable stage II to IIIB disease or recurrent disease after surgical resection, and could tolerate concurrent chemoradiation...
November 3, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29239732/too-big-to-fail-the-current-status-of-proton-therapy-in-the-usa
#14
EDITORIAL
A L Zietman
No abstract text is available yet for this article.
November 24, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29239528/quantifying-the-effect-of-air-gap-depth-and-range-shifter-thickness-on-tps-dosimetric-accuracy-in-superficial-pbs-proton-therapy
#15
Robert J Shirey, Hsinshun Terry Wu
This study quantifies the dosimetric accuracy of a commercial treatment planning system as functions of treatment depth, air gap, and range shifter thickness for superficial pencil beam scanning proton therapy treatments. The RayStation 6 pencil beam and Monte Carlo dose engines were each used to calculate the dose distributions for a single treatment plan with varying range shifter air gaps. Central axis dose values extracted from each of the calculated plans were compared to dose values measured with a calibrated PTW Markus chamber at various depths in RW3 solid water...
December 14, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29239262/outcomes-following-proton-therapy-for-pediatric-ependymoma
#16
Daniel J Indelicato, Julie A Bradley, Ronny L Rotondo, Ronica H Nanda, Natalie Logie, Eric S Sandler, Philipp R Aldana, Nathan J Ranalli, Alexandra D Beier, Christopher G Morris, Nancy P Mendenhall
BACKGROUND: Proton therapy can reduce the low and intermediate radiation dose to uninvolved brain tissue in children with intracranial ependymomas, which may improve functional outcomes and reduce second malignancies in survivors. Accordingly, ependymoma has become the most common pediatric tumor treated with proton therapy, yet data on efficacy and toxicity are limited. MATERIAL AND METHODS: Between June 2007 and February 2017, 179 children (≤21 years old) with nonmetastatic grade II/III intracranial ependymoma received proton therapy at our institution...
December 14, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29237962/evaluation-of-the-effect-of-soft-tissue-composition-on-the-characteristics-of-spread-out-bragg-peak-in-proton-therapy
#17
Mahdi Ghorbani, Sayyed Bijan Jia, Mohsen Khosroabadi, Hamid Reza Sadoughi, Courtney Knaup
AIM: The aim of this study is to evaluate the effect of soft tissue composition on dose distribution and spread-out Bragg peak (SOBP) characteristics in proton therapy. SUBJECTS AND METHODS: Proton beams with nominal energies of 70, 120 and 210 MeV were considered. The soft tissues and tissue equivalent materials implemented in this study are: 9-component soft tissue, 4-component soft tissue, adipose tissue, muscle (skeletal), lung tissue, breast tissue, A-150 tissue equivalent plastic, perspex and water...
October 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29235439/theoretical-analysis-of-angular-distribution-of-scattering-in-nozzle-components-using-a-response-function-method-for-proton-spot-scanning-therapy
#18
Hideaki Ueda, Michihiro Furusaka, Taeko Matsuura, Shusuke Hirayama, Kikuo Umegaki
In spot-scanning proton therapy, highly precise beam control is required in the treatment nozzle such that the proton beam does not spread out during transportation by restraining the divergence of the beam angle and spot size, simultaneously. In order to evaluate the beam-broadening behaviour induced by passing through the various nozzle components, we have developed a new method to calculate the angular divergence profile of a proton beam in the nozzle. The angular divergence of the proton beam for each nozzle component is calculated by the Monte Carlo simulation code, Geant4, assuming that the initial beam has no divergence...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29226038/pencil-beam-scanning-proton-therapy-for-rhabdomyosarcoma-of-the-biliary-tract
#19
Luke Pater, Brian Turpin, Anthony Mascia
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood with 250-350 cases diagnosed annually in the United States. Biliary tract rhabdomyosarcoma is rare, representing <1% of the RMS cases. Due to its location, resection is clinically challenging, and functional complications exist and persist from biliary obstruction. The anatomical location of this tumor presents both opportunities and challenges for pencil beam scanning proton therapy. Proton therapy offers a dosimetric and clinical advantage by sparing the healthy liver, stomach, contra-lateral kidney and bowel...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29222950/tolerance-design-of-patient-specific-range-qa-using-the-dmaic-framework-in-proton-therapy
#20
Jeong-Eun Rah, Dongho Shin, Ryan P Manger, Tae Hyun Kim, Do Hoon Oh, Dae Yong Kim, Gwe-Ya Kim
PURPOSE: To implement the DMAIC (Define-Measure-Analyze-Improve-Control) can be used for customizing the patient-specific QA by designing site-specific range tolerances. METHODS: The DMAIC framework (process flow diagram, cause and effect, Pareto chart, control chart, and capability analysis) were utilized to determine the steps that need focus for improving the patient-specific QA. The patient-specific range QA plans were selected according to 7 treatment site groups, a total of 1437 cases...
December 9, 2017: Medical Physics
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