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"proton therapy"

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https://www.readbyqxmd.com/read/28921843/potential-proton-and-photon-dose-degradation-in-advanced-head-and-neck-cancer-patients-by-intratherapy-changes
#1
Kristin Stützer, Annika Jakobi, Anna Bandurska-Luque, Steffen Barczyk, Carolin Arnsmeyer, Steffen Löck, Christian Richter
PURPOSE: Evaluation of dose degradation by anatomic changes for head-and-neck cancer (HNC) intensity-modulated proton therapy (IMPT) relative to intensity-modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation. METHODS: For 31 advanced HNC datasets, IMPT and IMRT plans were recalculated on a computed tomography scan (CT) taken after about 4 weeks of therapy. Dose parameter changes were determined for the organs at risk (OARs) spinal cord, brain stem, parotid glands, brachial plexus, and mandible, for the clinical target volume (CTV) and the healthy tissue outside planning target volume (PTV)...
September 18, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28918679/relating-the-proton-relative-biological-effectiveness-to-tumor-control-and-normal-tissue-complication-probabilities-assuming-interpatient-variability-in-%C3%AE-%C3%AE
#2
Harald Paganetti
BACKGROUND: Proton therapy uses a constant relative biological effectiveness (RBE) of 1.1. The use of variable RBE values has been suggested but is currently not feasible due to uncertainties. The impact of variable RBE has solely been studied using dosimetric indices. This work elucidates the impact of RBE variations on tumor control and normal tissue complication probabilities (TCP/NTCP). METHODS: Models to estimate TCP and NTCP were used in combination with an empirical proton RBE model...
September 18, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28917586/dosimetric-comparison-to-the-heart-and-cardiac-substructure-in-a-large-cohort-of-esophageal-cancer-patients-treated-with-proton-beam-therapy-or-intensity-modulated-radiation-therapy
#3
Yutaka Shiraishi, Cai Xu, Jinzhong Yang, Ritsuko Komaki, Steven H Lin
PURPOSE: To compare heart and cardiac substructure radiation exposure using intensity-modulated radiotherapy (IMRT) vs. proton beam therapy (PBT) for patients with mid- to distal esophageal cancer who received chemoradiation therapy. METHODS AND MATERIALS: We identified 727 esophageal cancer patients who received IMRT (n=477) or PBT (n=250) from March 2004 to December 2015. All patients were treated to 50.4Gy with IMRT or to 50.4 cobalt Gray equivalents with PBT...
September 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28913176/propensity-score-matched-comparison-of-intensity-modulated-radiation-therapy-vs-stereotactic-body-radiation-therapy-for-localized-prostate-cancer-a-survival-analysis-from-the-national-cancer-database
#4
Anthony Ricco, Alexandra Hanlon, Rachelle Lanciano
PURPOSE: No direct comparisons between extreme hypofractionation and conventional fractionation have been reported in randomized trials for the treatment of localized prostate cancer. The goal of this study is to use a propensity score matched (PSM) analysis with the National Cancer Database (NCDB) for the comparison of stereotactic body radiation therapy (SBRT) and intensity modulated radiation therapy (IMRT) for organ confined prostate cancer. METHODS: Men with localized prostate cancer treated with radiation dose ≥72 Gy for IMRT and ≥35 Gy for SBRT to the prostate only were abstracted from the NCDB...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28911093/consolidative-proton-therapy-after-chemotherapy-for-patients-with-hodgkin-lymphoma
#5
B S Hoppe, C E Hill-Kayser, Y D Tseng, S Flampouri, H M Elmongy, O Cahlon, N P Mendenhall, A Maity, L A McGee, J P Plastaras
Background: We investigated early outcomes for patients receiving chemotherapy followed by consolidative proton therapy (PT) for the treatment of Hodgkin lymphoma (HL). Patients and methods: From June 2008 through August 2015, 138 patients with HL enrolled on either IRB-approved outcomes tracking protocols or registry studies received consolidative PT. Patients were excluded due to relapsed or refractory disease. Involved-site radiotherapy field designs were used for all patients...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28911077/proton-therapy-in-mediastinal-hodgkin-lymphoma-moving-from-dosimetric-prediction-to-clinical-evidence
#6
U Ricardi, B Dabaja, D C Hodgson
No abstract text is available yet for this article.
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28901947/a-robust-optimisation-approach-accounting-for-the-effect-of-fractionation-on-setup-uncertainties
#7
Matthew Lowe, Adam Henry Aitkenhead, Francesca Albertini, Antony John Lomax, Ranald I Mackay
Proton plans are subject to a number of uncertainties which must be accounted for to ensure that they are delivered safely. Misalignment resulting from residual errors in daily patient positioning can result in both a displacement and distortion of dose distributions. This can be particularly important for intensity modulated proton therapy treatments where the accurate alignment of highly modulated fields may be required to deliver the intended treatment. A number of methods to generate plans that are robust to these uncertainties exist...
September 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28887837/characterisation-of-proton-pencil-beam-scanning-and-passive-beam-using-a-high-spatial-resolution-solid-state-microdosimeter
#8
Linh T Tran, Lachlan Chartier, David Bolst, Alex Pogossov, Susanna Guatelli, Marco Petasecca, Michael L F Lerch, Dale A Prokopovich, Mark I Reinhard, Benjamin Clasie, Nicolas Depauw, Hanne Kooy, Jacob B Flanz, Aimee McNamara, Harald Paganetti, Chris Beltran, Keith Furutani, Vladimir L Perevertaylo, Michael Jackson, Anatoly B Rosenfeld
PURPOSE: This work aims to characterise a proton pencil-beam scanning (PBS) and passive double scattering (DS) systems as well as to measure parameters relevant to the relative biological effectiveness (RBE) of the beam using a silicon-on-insulator (SOI) microdosimeter with well-defined 3D sensitive volumes (SV). The dose equivalent downstream and laterally outside of a clinical PBS treatment field was assessed and compared to that of a DS beam. METHODS: A novel silicon microdosimeter with well-defined 3D SVs was used in this study...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28880369/optimization-of-beam-arrangements-in-proton-minibeam-radiotherapy-by-cell-survival-simulations
#9
Matthias Sammer, Christoph Greubel, Stefanie Girst, Günther Dollinger
PURPOSE: Proton minibeam radiotherapy using sub-millimeter beam dimensions allows to enhance tissue sparing in the entrance channel by spatial fractionation additionally to advantageous proton depth dose distribution. In the entrance channel, spatial fractionation leads to reduced side effects compared to conventional proton therapy. The sub-millimeter sized beams widen with depth due to small angle scattering and enable therefore, in contrary to x-ray microbeam radiation therapy (MRT), the homogeneous irradiation of a tumor...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28879658/long-term-outcomes-in-patients-treated-with-proton-therapy-for-localized-prostate-cancer
#10
Masaru Takagi, Yusuke Demizu, Kazuki Terashima, Osamu Fujii, Dongcun Jin, Yasue Niwa, Takashi Daimon, Masao Murakami, Nobukazu Fuwa, Tomoaki Okimoto
The aim of this retrospective study was to report long-term clinical outcomes in patients treated with proton therapy (PT) for localized prostate cancer. Between 2001 and 2014, 1375 consecutive patients were treated with PT. Patients were classified into prognostic risk groups based on the National Comprehensive Cancer Network criteria. Freedom from biochemical relapse (FFBR), cancer-specific survival (CSS) and incidence of late gastrointestinal (GI)/genitourinary (GU) toxicities were calculated. Multivariate analysis was performed to identify clinical prognostic factors for FFBR and late toxicities...
September 6, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28872001/pulmonary-toxicity-following-proton-therapy-for-thoracic-lymphoma
#11
Ronica Nanda, Stella Flampouri, Nancy P Mendenhall, Daniel J Indelicato, Lisa M Jones, Vandana K Seeram, Bradford S Hoppe
No abstract text is available yet for this article.
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871993/predicted-rate-of-secondary-malignancies-following-adjuvant-proton-versus-photon-radiation-therapy-for-thymoma
#12
J Vogel, L Lin, L A Litzky, A T Berman, C B Simone
PURPOSE: Thymic malignancies are the most common tumors of the anterior mediastinum. The benefit of adjuvant radiation therapy for stage II disease remains controversial, and patients treated with adjuvant radiation therapy are at risk of late complications, including radiation-induced secondary malignant neoplasms (SMNs), that may reduce the overall benefit of treatment. We assess the risk of predicted SMNs following adjuvant proton radiation therapy compared with photon radiation therapy after resection of stage II thymic malignancies to determine whether proton therapy improves the risk-benefit ratio...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28871980/empowering-intensity-modulated-proton-therapy-through-physics-and-technology-an-overview
#13
REVIEW
Radhe Mohan, Indra J Das, Clifton C Ling
Considering the clinical potential of protons attributable to their physical characteristics, interest in proton therapy has increased greatly in this century, as has the number of proton therapy installations. Until recently, passively scattered proton therapy was used almost entirely. Notably, the overall clinical results to date have not shown a convincing benefit of protons over photons. A rapid transition is now occurring with the implementation of the most advanced form of proton therapy, intensity modulated proton therapy (IMPT)...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28869195/-proton-therapy-for-head-and-neck-cancers
#14
P Blanchard, S J Frank
The absence of exit dose and the sharp lateral penumbra are key assets for proton therapy, which are responsible for its dosimetric superiority over advanced photon radiotherapy. Dosimetric comparisons have consistently shown a reduction of the integral dose and the dose to organs at risk favouring intensity-modulated proton therapy (IMPT) over intensity-modulated radiotherapy (IMRT). The structures that benefit the most of these dosimetric improvements in head and neck cancers are the anterior oral cavity, the posterior fossa, the visual apparatus and swallowing structures...
August 28, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28867546/reirradiation-of-thoracic-cancers-with-intensity-modulated-proton-therapy
#15
Jennifer C Ho, Quynh-Nhu Nguyen, Heng Li, Pamela K Allen, Xiaodong Zhang, Zhongxing Liao, X Ronald Zhu, Daniel Gomez, Steven H Lin, Michael Gillin, Ritsuko Komaki, Stephen Hahn, Joe Y Chang
PURPOSE: Reirradiation of thoracic malignancies is a treatment challenge, with concerns for toxicity and the inability to deliver definitive doses. Intensity modulated proton therapy (IMPT) may allow safe delivery of a higher dose of radiation to the tumor while minimizing toxicities. METHODS AND MATERIALS: Between 2011 and 2016, 27 patients who received IMPT for reirradiation of thoracic malignancies with definitive intent were retrospectively analyzed. Patients were included if they received a prior thoracic radiation course...
July 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28862209/accelerator-driven-neutron-source-design-via-beryllium-target-and-208-pb-moderator-for-boron-neutron-capture-therapy-in-alternative-treatment-strategy-by-monte-carlo-method
#16
Abdollah Khorshidi
AIMS: The reactor has increased its area of application into medicine especially boron neutron capture therapy (BNCT); however, accelerator-driven neutron sources can be used for therapy purposes. The present study aimed to discuss an alternative method in BNCT functions by a small cyclotron with low current protons based on Karaj cyclotron in Iran. MATERIALS AND METHODS: An epithermal neutron spectrum generator was simulated with 30 MeV proton energy for BNCT purposes...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28843397/experimental-validation-of-a-4d-dose-calculation-routine-for-pencil-beam-scanning-proton-therapy
#17
T Pfeiler, C Bäumer, E Engwall, D Geismar, B Spaan, B Timmermann
Respiratory induced organ motion poses a major challenge for high-precision radiotherapy such as pencil beam scanning proton therapy (PBS). In order to employ PBS for target regions affected by respiratory motion, the implementation of dedicated motion mitigation techniques should be considered and residual uncertainties need to be assessed. For the latter purpose, a routine simulating the delivery of a scanned proton beam to a moving target was developed and implemented in the commercial treatment planning system RayStation...
August 23, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/28843371/pencil-beam-algorithms-are-unsuitable-for%C3%A2-proton-dose-calculations-in-lung
#18
Paige A Taylor, Stephen F Kry, David S Followill
PURPOSE: To compare analytic and Monte Carlo-based algorithms for proton dose calculations in the lung, benchmarked against anthropomorphic lung phantom measurements. METHODS AND MATERIALS: A heterogeneous anthropomorphic moving lung phantom has been irradiated at numerous proton therapy centers. At 5 centers the treatment plan could be calculated with both an analytic and Monte Carlo algorithm. The doses calculated in the treatment plans were compared with the doses delivered to the phantoms, which were measured using thermoluminescent dosimeters and film...
June 13, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28838605/life-years-lost-attributable-to-late-effects-after-radiotherapy-for-early-stage-hodgkin-lymphoma-the-impact-of-proton-therapy-and-or-deep-inspiration-breath-hold
#19
Laura Ann Rechner, Maja Vestmø Maraldo, Ivan Richter Vogelius, Xiaorong Ronald Zhu, Bouthaina Shbib Dabaja, Nils Patrik Brodin, Peter Meidahl Petersen, Lena Specht, Marianne Camille Aznar
BACKGROUND AND PURPOSE: Due to the long life expectancy after treatment, the risk of late effects after radiotherapy (RT) is of particular importance for patients with Hodgkin lymphoma (HL). Both deep inspiration breath hold (DIBH) and proton therapy have been shown to reduce the dose to normal tissues for mediastinal HL, but the impact of these techniques in combination is unknown. The purpose of this study was to compare the life years lost (LYL) attributable to late effects after RT for mediastinal HL using intensity modulated radiation therapy (IMRT) in free breathing (FB) and DIBH, and proton therapy in FB and DIBH...
August 21, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28835182/proton-radiography-for-inline-treatment-planning-and-positioning-verification-of-small-animals
#20
Johannes Müller, Christian Neubert, Cläre von Neubeck, Michael Baumann, Mechthild Krause, Wolfgang Enghardt, Rebecca Bütof, Antje Dietrich, Armin Lühr
INTRODUCTION: As proton therapy becomes increasingly well established, there is a need for high-quality clinically relevant in vivo data to gain better insight into the radiobiological effects of proton irradiation on both healthy and tumor tissue. This requires the development of easily applicable setups that allow for efficient, fractionated, image-guided proton irradiation of small animals, the most widely used pre-clinical model. MATERIAL AND METHODS: Here, a method is proposed to perform dual-energy proton radiography for inline positioning verification and treatment planning...
August 23, 2017: Acta Oncologica
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