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https://www.readbyqxmd.com/read/27919760/proton-therapy-present-and-future
#1
REVIEW
Radhe Mohan, David Grosshans
In principle, proton therapy offers a substantial clinical advantage over the conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses, greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron or a synchrotron, are transported to the treatment room where they enter the treatment head mounted on a rotating gantry...
December 2, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27916516/local-dose-enhancement-of-proton-therapy-by-ceramic-oxide-nanoparticles-investigated-with-geant4-simulations
#2
Sally McKinnon, Susanna Guatelli, Sebastien Incerti, Vladimir Ivanchenko, Konstantin Konstantinov, Stéphanie Corde, Michael Lerch, Moeava Tehei, Anatoly Rosenfeld
Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta2O5 and CeO2, in the target tumour, for the first time in proton therapy, by means of Geant4 simulations...
December 1, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27911139/volumetric-response-of-intracranial-meningioma-after-photon-or-particle-irradiation
#3
Petra Mozes, Jan Oliver Dittmar, Daniel Habermehl, Eric Tonndorf-Martini, Katalin Hideghety, Anne Dittmar, Jürgen Debus, Stephanie E Combs
BACKGROUND: Meningiomas are usually slow growing, well circumscribed intracranial tumors. In symptom-free cases observation with close follow-up imaging could be performed. Symptomatic meningiomas could be surgically removed and/or treated with radiotherapy. The study aimed to evaluate the volumetric response of intracranial meningiomas at different time points after photon, proton, and a mixed photon and carbon ion boost irradiation. PATIENTS AND METHODS: In Group A 38 patients received proton therapy (median dose: 56 GyE in 1...
December 2, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27905257/proton-therapy-for-pediatric-cancer-are-we-ready-for-prime-time
#4
Tobias R Chapman, Ralph P Ermoian
No abstract text is available yet for this article.
January 2017: Future Oncology
https://www.readbyqxmd.com/read/27885084/analysis-of-neutron-production-in-passively-scattered-ion-beam-therapy
#5
Seunguk Heo, Seunghoon Yoo, Yongkeun Song, Eunho Kim, Jaeik Shin, Soorim Han, Wongyun Jung, Sanghee Nam, Rena Lee, Kitae Lee, Sungho Cho
A new treatment facility for heavy ion therapy since 2010 was constructed. In the broad beam, a range shifter, ridge filter and multi leaf collimator (MLC) for the generation of the spread-out Bragg peak is used. In this case, secondary neutrons produced by the interactions of the ion field with beam-modifying devices (e.g. double-scattering system, beam shaping collimators and range compensators) are very important for patient safety. Therefore, these components must be carefully examined in the context of secondary neutron yield and associated secondary cancer risk...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27875573/a-nucleoside-anticancer-drug-1-3-c-ethynyl-%C3%AE-d-ribo-pentofuranosyl-cytosine-induces-depth-dependent-enhancement-of-tumor-cell-death-in-spread-out-bragg-peak-sobp-of-proton-beam
#6
Kenichiro Maeda, Hironobu Yasui, Tohru Yamamori, Taeko Matsuura, Seishin Takao, Motofumi Suzuki, Akira Matsuda, Osamu Inanami, Hiroki Shirato
The effect of 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd) on proton-induced cell death was evaluated in human lung carcinoma cell line A549 and Chinese hamster fibroblast cell line V79 to enhance relative biological effectiveness (RBE) within the spread-out Bragg peak (SOBP) of proton beams. Treatment with ECyd significantly enhanced the proton-induced loss of clonogenicity and increased senescence at the center, but not at the distal edge of SOBP. The p53-binding protein 1 foci formation assay showed that ECyd decelerated the rate of DNA double-strand break (DSB) repair at the center, but not the distal region of SOBP, suggesting that the ECyd-induced enhancement of proton-induced cell death is partially associated with the inhibition of DSB repair...
2016: PloS One
https://www.readbyqxmd.com/read/27869083/spot-scanning-proton-arc-sparc-therapy-the-first-robust-and-delivery-efficient-spot-scanning-proton-arc-therapy
#7
Xuanfeng Ding, Xiaoqiang Li, J Michele Zhang, Peyman Kabolizadeh, Craig Stevens, Di Yan
PURPOSE: To present a novel robust and delivery-efficient spot-scanning proton arc (SPArc) therapy technique. METHODS AND MATERIALS: A SPArc optimization algorithm was developed that integrates control point resampling, energy layer redistribution, energy layer filtration, and energy layer resampling. The feasibility of such a technique was evaluated using sample patients: 1 patient with locally advanced head and neck oropharyngeal cancer with bilateral lymph node coverage, and 1 with a nonmobile lung cancer...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27869082/reoptimization-of-intensity-modulated-proton-therapy-plans-based-on-linear-energy-transfer
#8
Jan Unkelbach, Pablo Botas, Drosoula Giantsoudi, Bram L Gorissen, Harald Paganetti
PURPOSE: We describe a treatment plan optimization method for intensity modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume while limiting degradation of the best possible physical dose distribution. METHODS AND MATERIALS: To allow fast optimization based on dose and LET, a GPU-based Monte Carlo code was extended to provide dose-averaged LET in addition to dose for all pencil beams...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27867166/the-usefulness-of-using-fiducial-marker-in-proton-therapy-for-locally-advanced-pancreatic-cancer
#9
Masakazu Shimizu, Takahiro Sato, Yoshihide Sawa, Kazuki Terashima, Toshihiro Yanou, Ryoji Ida
BACKGROUND: Though the dosimetric criteria for the gastrointestinal tract were met, late gastrointestinal toxicity was seen in several cases. Therefore, we thought that it was caused by the positional variation of gastrointestine surrounding pancreatic cancer because of peristalsis. METHOD: They were confirmed by CT image regularly. And we evaluated that how much the difference of matching methods for correcting the positional variation influenced dose distribution...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27866523/-progress-on-the-therapeutic-approaches-for-malignant-tumor-%C3%A2-with-superior-vena-cava-syndrome
#10
Xiangzheng Liu, Shijie Zhang, Jian Li
Patients with thoracic malignant tumors often suffered from superior vena cava syndrome (SVCS), featured by high morbidity and mortality. Traditionally treated with palliative approaches, SVCS has been widely studied and novel therapeutic approaches have been investigated, focusing on drug therapy, interventional therapy, radiation therapy, surgery and proton therapy. In this manuscript, the progress of therapeutic approaches for SVCS is summarized.
November 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27863964/clinical-evidence-of-variable-proton-biological-effectiveness-in-pediatric-patients-treated-for-ependymoma
#11
Christopher R Peeler, Dragan Mirkovic, Uwe Titt, Pierre Blanchard, Jillian R Gunther, Anita Mahajan, Radhe Mohan, David R Grosshans
BACKGROUND AND PURPOSE: A constant relative biological effectiveness (RBE) is used for clinical proton therapy; however, experimental evidence indicates that RBE can vary. We analyzed pediatric ependymoma patients who received proton therapy to determine if areas of normal tissue damage indicated by post-treatment image changes were associated with increased biological dose effectiveness. MATERIAL AND METHODS: Fourteen of 34 children showed T2-FLAIR hyperintensity on post-treatment magnetic resonance (MR) images...
November 16, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27856039/impact-of-real-time-image-gating-on-spot-scanning-proton-therapy-for-lung-tumors-a%C3%A2-simulation-study
#12
Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
PURPOSE: To investigate the effectiveness of real-time-image gated proton beam therapy for lung tumors and to establish a suitable size for the gating window (GW). METHODS AND MATERIALS: A proton beam gated by a fiducial marker entering a preassigned GW (as monitored by 2 fluoroscopy units) was used with 7 lung cancer patients. Seven treatment plans were generated: real-time-image gated proton beam therapy with GW sizes of ±1, 2, 3, 4, 5, and 8 mm and free-breathing proton therapy...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27846903/prontox-proton-therapy-to-reduce-acute-normal-tissue-toxicity-in-locally-advanced-non-small-cell-lung-carcinomas-nsclc-study-protocol-for-a-randomised-controlled-trial
#13
Sebastian Zschaeck, Monique Simon, Steffen Löck, Esther G C Troost, Kristin Stützer, Patrick Wohlfahrt, Steffen Appold, Sebastian Makocki, Rebecca Bütof, Christian Richter, Michael Baumann, Mechthild Krause
BACKGROUND: Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation pneumonitis limit patients' quality of life, and the latter can be potentially life-threatening. Due to its distinct physical characteristics, proton therapy enables better sparing of normal tissues, which is supposed to translate into a reduction of radiation-induced side effects...
November 15, 2016: Trials
https://www.readbyqxmd.com/read/27829820/simulation-of-positron-emitters-for-monitoring-of-dose-distribution-in-proton-therapy
#14
Mohsen Mashayekhi, Ali Asghar Mowlavi, Sayyed Bijan Jia
AIM: The purpose of this work was to estimate the dependency between the produced positron emitters and the proton dose distribution as well as the dependency between points of annihilation and the proton dose distribution. BACKGROUND: One important feature of proton therapy is that, through the non-elastic nuclear interaction of protons with the target nuclei such as (12)C, (14)N and (16)O, it produces a small number of positron-emitting radioisotopes along the beam-path...
January 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/27818559/operation-of-the-preclinical-head-scanner-for-proton-ct
#15
H F-W Sadrozinski, T Geoghegan, E Harvey, R P Johnson, T E Plautz, A Zatserklyaniy, V Bashkirov, R F Hurley, P Piersimoni, R W Schulte, P Karbasi, K E Schubert, B Schultze, V Giacometti
We report on the operation and performance tests of a preclinical head scanner developed for proton computed tomography (pCT). After extensive preclinical testing, pCT is intended to be employed in support of proton therapy treatment planning and pre-treatment verification in patients undergoing particle-beam therapy. In order to assess the performance of the scanner, we have performed CT scans with 200 MeV protons from both the synchrotron of the Loma Linda University Medical Center (LLUMC) and the cyclotron of the Northwestern Medicine Chicago Proton Center (NMCPC)...
September 21, 2016: Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
https://www.readbyqxmd.com/read/27811403/prioritized-efficiency-optimization-for-intensity-modulated-proton-therapy
#16
Birgit S Müller, Jan J Wilkens
A high dosimetric quality and short treatment time are major goals in radiotherapy planning. Intensity modulated proton therapy (IMPT) plans obtain dose distributions of great conformity but often result in long delivery times which are typically not incorporated into the optimization process. We present an algorithm to optimize delivery efficiency of IMPT plans while maintaining plan quality, and study the potential trade-offs of these interdependent objectives. The algorithm is based on prioritized optimization, a stepwise approach to implemented objectives...
December 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27806620/factors-influencing-the-performance-of-patient-specific-quality-assurance-for-pencil-beam-scanning-impt-fields
#17
P Trnková, A Bolsi, F Albertini, D C Weber, A J Lomax
PURPOSE: A detailed analysis of 2728 intensity modulated proton therapy (IMPT) fields that were clinically delivered to patients between 2007 and 2013 at Paul Scherrer Institute (PSI) was performed. The aim of this study was to analyze the results of patient specific dosimetric verifications and to assess possible correlation between the quality assurance (QA) results and specific field metrics. METHODS: Dosimetric verifications were performed for every IMPT field prior to patient treatment...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27806617/the-visible-signal-responsible-for-proton-therapy-dosimetry-using-bare-optical-fibers-is-not-%C3%A4-erenkov-radiation
#18
Arash Darafsheh, Reza Taleei, Alireza Kassaee, Jarod C Finlay
PURPOSE: Proton beam dosimetry using bare plastic optical fibers has emerged as a simple approach to proton beam dosimetry. The source of the signal in this method has been attributed to Čerenkov radiation. The aim of this work was a phenomenological study of the nature of the visible light responsible for the signal in bare fiber optic dosimetry of proton therapy beams. METHODS: Plastic fiber optic probes embedded in solid water phantoms were irradiated with proton beams of energies 100, 180, and 225 MeV produced by a proton therapy cyclotron...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27806609/an-experimental-demonstration-of-a-new-type-of-proton-computed-tomography-using-a-novel-silicon-tracking-detector
#19
J T Taylor, G Poludniowski, T Price, C Waltham, P P Allport, G L Casse, M Esposito, P M Evans, S Green, S Manger, S Manolopoulos, J Nieto-Camero, D J Parker, J Symons, N M Allinson
PURPOSE: Radiography and tomography using proton beams promise benefit to image guidance and treatment planning for proton therapy. A novel proton tracking detector is described and experimental demonstrations at a therapy facility are reported. A new type of proton CT reconstructing relative "scattering power" rather than "stopping power" is also demonstrated. Notably, this new type of imaging does not require the measurement of the residual energies of the protons. METHODS: A large area, silicon microstrip tracker with high spatial and temporal resolution has been developed by the Proton Radiotherapy Verification and Dosimetry Applications consortium and commissioned using beams of protons at iThemba LABS, Medical Radiation Department, South Africa...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27806590/a-scintillator-based-approach-to-monitor-secondary-neutron-production-during-proton-therapy
#20
S D Clarke, E Pryser, B M Wieger, S A Pozzi, R A Haelg, V A Bashkirov, R W Schulte
PURPOSE: The primary objective of this work is to measure the secondary neutron field produced by an uncollimated proton pencil beam impinging on different tissue-equivalent phantom materials using organic scintillation detectors. Additionally, the Monte Carlo code mcnpx-PoliMi was used to simulate the detector response for comparison to the measured data. Comparison of the measured and simulated data will validate this approach for monitoring secondary neutron dose during proton therapy...
November 2016: Medical Physics
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