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https://www.readbyqxmd.com/read/29765819/complications-in-salvage-surgery-for-nasal-and-paranasal-malignant-tumors-involving-the-skull-base
#1
Masanori Teshima, Hirotaka Shinomiya, Naoki Otsuki, Hidehito Kimura, Masaaki Taniguchi, Kazunobu Hashikawa, Eiji Kohmura, Ken-Ichi Nibu
Objective  Nasal and paranasal malignant tumors invading the skull base are rare and poorly studied. We evaluated postoperative complications in patients undergoing salvage surgery for such tumors. Design  Retrospective study. Setting  Kobe University Hospital. Participants  Among 48 patients who underwent surgery for tumors involving the skull base between 1993 and 2015, 21 patients had squamous cell carcinoma, 13 had olfactory neuroblastoma, 5 had adenocarcinoma, 2 had sarcoma, 2 had adenoid cystic carcinoma, and 1 each had malignant melanoma, poorly differentiated carcinoma, undifferentiated carcinoma, myoepithelial carcinoma, and malignant peripheral nerve sheath tumor...
June 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29752180/-177-lu-psma-617-radionuclide-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-lupsma-trial-a-single-centre-single-arm-phase-2-study
#2
Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu
BACKGROUND: Progressive metastatic castration-resistant prostate cancer is a highly lethal disorder and new effective therapeutic agents that improve patient outcomes are urgently needed. Lutetium-177 [177 Lu]-PSMA-617, a radiolabelled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA) enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer. We aimed to investigate the safety, efficacy, and effect on quality of life of [177 Lu]-PSMA-617 in men with metastatic castration-resistant prostate cancer who progressed after standard treatments...
May 7, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29739417/evaluation-of-particle-radiotherapy-for-the-re-irradiation-of-recurrent-intracranial-meningioma
#3
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: With the advance of modern irradiation techniques, the role of radiotherapy (RT) for intracranial meningioma has increased significantly throughout the past years. Despite that tumor's generally favorable outcome with local control rates of up to 90% after ten years, progression after RT does occur. In those cases, re-irradiation is often difficult due to the limited radiation tolerance of the surrounding tissue. The aim of this analysis is to determine the value of particle therapy with its better dose conformity and higher biological efficacy for re-irradiating recurrent intracranial meningioma...
May 8, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29726401/adaptation-of-stochastic-microdosimetric-kinetic-model-for-charged-particle-therapy-treatment-planning
#4
T Inaniwa, N Kanematsu
The microdosimetric kinetic (MK) model underestimates the cell-survival fractions for high linear energy transfer (LET) and high dose irradiations. To address the issue, some researchers previously extended the MK model to the stochastic microdosimetric kinetic (SMK) model. In the SMK model, the radiation induced cell-survival fractions were estimated from the specific energies z d and z n absorbed by a microscopic subnuclear structure domain and a cell nucleus, respectively. By taking the stochastic nature of z n as well as that of z d into account, the SMK model could reproduce the measured cell-survival fractions for radiations with wide LET and dose ranges...
May 4, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29703502/improving-the-modelling-of-irradiation-induced-brain-activation-for-in-vivo-pet-verification-of-proton-therapy
#5
Julia Bauer, Wenjing Chen, Sebastian Nischwitz, Jakob Liebl, Stefan Rieken, Thomas Welzel, Juergen Debus, Katia Parodi
BACKGROUND AND PURPOSES: A reliable Monte Carlo prediction of proton-induced brain tissue activation used for comparison to particle therapy positron-emission-tomography (PT-PET) measurements is crucial for in vivo treatment verification. Major limitations of current approaches to overcome include the CT-based patient model and the description of activity washout due to tissue perfusion. MATERIAL AND METHODS: Two approaches were studied to improve the activity prediction for brain irradiation: (i) a refined patient model using tissue classification based on MR information and (ii) a PT-PET data-driven refinement of washout model parameters...
April 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29703500/overview-of-research-and-therapy-facilities-for-radiobiological-experimental-work-in-particle-therapy-report-from-the-european-particle-therapy-network-radiobiology-group
#6
REVIEW
Manjit Dosanjh, Bleddyn Jones, Jörg Pawelke, Martin Pruschy, Brita Singers Sørensen
Particle therapy (PT) as cancer treatment, using protons or heavier ions, can provide a more favorable dose distribution compared to X-rays. While the physical characteristics of particle radiation have been the aim of intense research, less focus has been placed on the actual biological responses arising from particle irradiation. One of the biggest challenges for proton radiobiology is the RBE, with an increasing concern that the clinically-applied generic RBE-value of 1.1 is an approximation, as RBE is a complex quantity, depending on both biological and physical parameters, such as dose, LET, cellular and tissue radiobiological characteristics, as well as the endpoints being studied...
April 24, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29664326/targeted-alpha-particle-therapy-imaging-dosimetry-and-radiation-protection
#7
M Lassmann, U Eberlein
Systemic or locoregionally administered alpha-particle emitters are highly potent therapeutic agents used in oncology that are fundamentally novel in their mechanism and, most likely, overcome radiation resistance as the alpha particles emitted have a short range and a high linear energy transfer. The use of alpha emitters in a clinic environment requires extra measures with respect to imaging, dosimetry, and radiation protection. This is shown for the example of 223 Ra dichloride therapy. After intravenous injection, 223 Ra leaves the blood and is taken up rapidly in bone and bone metastases; it is mainly excreted via the intestinal tract...
January 1, 2018: Annals of the ICRP
https://www.readbyqxmd.com/read/29625810/enlight-european-network-for-light-ion-hadron-therapy
#8
REVIEW
Manjit Dosanjh, Ugo Amaldi, Ramona Mayer, Richard Poetter
The European Network for Light Ion Hadron Therapy (ENLIGHT) was established in 2002 following various European particle therapy network initiatives during the 1980s and 1990s (e.g. EORTC task group, EULIMA/PIMMS accelerator design). ENLIGHT started its work on major topics related to hadron therapy (HT), such as patient selection, clinical trials, technology, radiobiology, imaging and health economics. It was initiated through CERN and ESTRO and dealt with various disciplines such as (medical) physics and engineering, radiation biology and radiation oncology...
April 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29624212/effectiveness-of-base-of-skull-immobilization-system-in-a-compact-proton-therapy-setting
#9
Ghazal Shafai-Erfani, Twyla Willoughby, Naren Ramakrishna, Sanford Meeks, Patrick Kelly, Omar Zeidan
PURPOSE: The purpose of this study was to investigate daily repositioning accuracy by analyzing inter- and intra-fractional uncertainties associated with patients treated for intracranial or base of skull tumors in a compact proton therapy system with 6 degrees of freedom (DOF) robotic couch and a thermoplastic head mask indexed to a base of skull (BoS) frame. MATERIALS AND METHODS: Daily orthogonal kV alignment images at setup position before and after daily treatments were analyzed for 33 patients...
April 6, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29606525/economic-data-for-particle-therapy-dealing-with-different-needs-in-a-heterogeneous-landscape
#10
Yolande Lievens, Klaus Nagels
BACKGROUND: In the light of scarce resources to be allocated for cancer care and a steady stream of costly innovations in all modalities applied to treat cancer, particle therapy needs to demonstrate its cost-utility balance to allow its positioning in the context of competing modalities. In the continuous evolving particle therapy landscape, the timely availability of appropriate economic data is crucial. METHODS: Economic data collection and compilation for particle therapy needs to follow health economic standards...
March 29, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29605478/practice-patterns-of-image-guided-particle-therapy-in-europe-a-2016-survey-of-the-european-particle-therapy-network-eptn
#11
Alessandra Bolsi, Marta Peroni, Dante Amelio, Alexandru Dasu, Markus Stock, Iuliana Toma-Dasu, Petra Witt Nyström, Aswin Hoffmann
BACKGROUND AND PURPOSE: Image guidance is critical in achieving accurate and precise radiation delivery in particle therapy, even more than in photon therapy. However, equipment, quality assurance procedures and clinical workflows for image-guided particle therapy (IGPT) may vary substantially between centres due to a lack of standardization. A survey was conducted to evaluate the current practice of IGPT in European particle therapy centres. MATERIAL AND METHODS: In 2016, a questionnaire was distributed among 19 particle therapy centres in 12 European countries...
March 28, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29594239/the-posterior-cerebellum-a-new-organ-at-risk
#12
EDITORIAL
Daniëlle B P Eekers, Lieke In 't Ven, Sabine Deprez, Linda Jacobi, Erik Roelofs, Ann Hoeben, Philippe Lambin, Dirk de Ruysscher, Esther G C Troost
Eekers et al. have recently proposed a neuro-oncology atlas, which was co-authored by most centers associated in the European Proton Therapy Network (EPTN; Figure 1). With the introduction of new treatment techniques, such as integrated magnetic resonance imaging and linear accelerators (MR-linac) or particle therapy, the prediction of clinical efficacy of these more costly treatment modalities becomes more relevant. One of the side-effects of brain irradiation, being cognitive decline, is one of the toxicities most difficult to measure and predict...
January 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29587795/clinical-outcome-after-particle-therapy-for-meningiomas-of-the-skull-base-toxicity-and-local-control-in-patients-treated-with-active-rasterscanning
#13
Rami A El Shafie, Maja Czech, Kerstin A Kessel, Daniel Habermehl, Dorothea Weber, Stefan Rieken, Nina Bougatf, Oliver Jäkel, Jürgen Debus, Stephanie E Combs
BACKGROUND: Meningiomas of the skull base account for 25-30% of all meningiomas. Due to the complex structure of the cranial base and its close proximity to critical structures, surgery is often associated with substantial morbidity. Treatment options include observation, aggressive surgical intervention, stereotactic or conventional radiotherapy. In this analysis we evaluate the outcome of 110 patients with meningiomas of the skull base treated with particle therapy. It was performed within the framework of the "clinical research group heavy ion therapy" and supported by the German Research Council (DFG, KFO 214)...
March 27, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29573922/monaco-treatment-planning-system-tools-and-optimization-processes
#14
REVIEW
Mac Clements, Nicholas Schupp, Megan Tattersall, Anthony Brown, Randy Larson
The Monaco treatment planning system combines Monte Carlo dose calculation accuracy with robust optimization tools to provide high-quality radiotherapy treatment plans for three-dimensional conformal radiotherapy (3D CRT), intensity modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), stereotactic radiosurgery (SRS), and stereotactic body radiotherapy (SBRT). Recent technology advances have allowed for fast calculation speeds, which allow clinicians and patients to benefit from the accuracy of the Monte Carlo algorithm while reducing overall planning time...
March 22, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29572856/the-relative-biological-effectiveness-for-carbon-nitrogen-and-oxygen-ion-beams-using-passive-and-scanning-techniques-evaluated-with-fully-3d-silicon-microdosimeters
#15
Linh T Tran, David Bolst, Susanna Guatelli, Alex Pogossov, Marco Petasecca, Michael L F Lerch, Lachlan Chartier, Dale A Prokopovich, Mark I Reinhard, Marco Povoli, Angela Kok, Vladimir L Perevertaylo, Naruhiro Matsufuji, Tatsuaki Kanai, Michael Jackson, Anatoly B Rosenfeld
BACKGROUND: The aim of this study was to measure the microdosimetric distributions of a carbon pencil-beam scanning (PBS) and passive scattering system as well as to evaluate the relative biological effectiveness (RBE) of different ions, namely12 C,14 N and16 O, using a silicon-on-insulator (SOI) microdosimeter with well-defined 3D sensitive volumes (SV). Geant4 simulations were performed with the same experimental setup and results were compared to the experimental results for benchmarking...
March 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29548560/the-eptn-consensus-based-atlas-for-ct-and-mr-based-contouring-in-neuro-oncology
#16
Daniëlle Bp Eekers, Lieke In 't Ven, Erik Roelofs, Alida Postma, Claire Alapetite, Neil G Burnet, Valentin Calugaru, Inge Compter, Ida E M Coremans, Morton Høyer, Maarten Lambrecht, Petra Witt Nyström, Alejandra Méndez Romero, Frank Paulsen, Ana Perpar, Dirk de Ruysscher, Laurette Renard, Beate Timmermann, Pavel Vitek, Damien C Weber, Hiske L van der Weide, Gillian A Whitfield, Ruud Wiggenraad, Esther G C Troost
PURPOSE: To create a digital, online atlas for organs at risk (OAR) delineation in neuro-oncology based on high-quality computed tomography (CT) and magnetic resonance (MR) imaging. METHODS: CT and 3 Tesla (3T) MR images (slice thickness 1 mm with intravenous contrast agent) were obtained from the same patient and subsequently fused. In addition, a 7T MR without intravenous contrast agent was obtained from a healthy volunteer. Based on discussion between experienced radiation oncologists, the clinically relevant organs at risk (OARs) to be included in the atlas for neuro-oncology were determined, excluding typical head and neck OARs previously published...
March 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29547526/stereotactic-radiotherapy-and-particle-therapy-for-pancreatic-cancer
#17
REVIEW
Sweet Ping Ng, Joseph M Herman
Pancreatic cancer is a devastating disease with poor survival outcomes. Recent studies have shown that the addition of radiotherapy to chemotherapy in the setting of locally advanced pancreatic cancer did not improve overall survival outcome. These studies commonly utilize conventional radiotherapy treatment fractionation and technique (typically 3-D conformal radiotherapy or intensity modulated radiotherapy). Although no clear benefit in overall survival was demonstrated in those studies, those who received radiotherapy did have a clear benefit in terms of local control...
March 16, 2018: Cancers
https://www.readbyqxmd.com/read/29544511/online-advertising-and-marketing-claims-by-providers-of-proton-beam-therapy-are-they-guideline-based
#18
Mark T Corkum, Wei Liu, David A Palma, Glenn S Bauman, Robert E Dinniwell, Andrew Warner, Mark V Mishra, Alexander V Louie
BACKGROUND: Cancer patients frequently search the Internet for treatment options, and hospital websites are seen as reliable sources of knowledge. Guidelines support the use of proton radiotherapy in specific disease sites or on clinical trials. This study aims to evaluate direct-to-consumer advertising content and claims made by proton therapy centre (PTC) websites worldwide. METHODS: Operational PTC websites in English were identified through the Particle Therapy Co-Operative Group website...
March 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29537642/characterization-of-a-multi-layer-ionization-chamber-prototype-for-fast-verification-of-relative-depth-ionization-curves-and-spread-out-bragg-peaks-in-light-ion-beam-therapy
#19
Alfredo Mirandola, Giuseppe Magro, Marco Lavagno, Andrea Mairani, Silvia Molinelli, Stefania Russo, Edoardo Mastella, Alessandro Vai, Davide Maestri, Vanessa La Rosa, Mario Ciocca
PURPOSE: To dosimetrically characterize a multi-layer ionization chamber (MLIC) prototype for quality assurance (QA) of pristine integral ionization curves (ICs) and spread-out-Bragg-peaks (SOBPs) for scanning light ion beams. METHODS: QUBE (De.Tec.Tor., Torino, Italy) is a modular detector designed for QA in particle therapy (PT). Its main module is a MLIC detector, able to evaluate particle beam relative depth ionization distributions at different beam energies and modulations...
March 14, 2018: Medical Physics
https://www.readbyqxmd.com/read/29531857/adenoid-cystic-carcinoma-focus-on-heavy-ion-therapy-and-molecular-imaging
#20
REVIEW
Angelo Castello, Laura Olivari, Egesta Lopci
Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest into the use of heavy particle (e.g. protons or heavy ions) in the treatment of solid tumors. However, the restricted availability of the technology has concentrated the expertise in highly specialized centers that take care and treat extreme cases and rare pathologies...
2018: American Journal of Nuclear Medicine and Molecular Imaging
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