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https://www.readbyqxmd.com/read/28924096/revision-of-calibration-method-of-ct-number-to-stopping-power-ratio-conversion-for-treatment-planning-of-particle-therapy
#1
Nobuyuki Kanematsu, Shinichiro Mori, Taku Inaniwa
A calibration method for CT-number to stopping-power-ratio conversion was recently proposed as a revision of the Japanese de facto standard method that has been used at particle therapy centers in Japan for over a decade. The revised method deals with 11 representative tissues of specific elemental composition and density, based on a latest compilation of standard tissue data. We report here how the revision was actually implemented into clinical practice. We applied the revised method to 7 CT-scanning conditions currently in use for treatment planning...
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/28886211/homogeneity-study-of-proton-and-carbon-ion-scanning-beams-using-combinations-of-different-spot-sizes-and-grid-sizes
#2
Ying Xing, Xianwei Wu, Yongqiang Li, Jun Zhao
PURPOSE: Different scanning ion beam delivery systems have different delivery accuracies, and the resulting delivery errors will affect field homogeneity. This study was performed to determine an appropriate combination of spot size (FWHM) and spot grid size (GS), which can provide homogenous dose distributions for both proton and carbon ion scanning beam radiotherapy. The combination of the two parameters is represented by a combination factor named n, which is the quotient of FWHM divided by GS...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28871342/a-systematic-review-of-publications-on-charged-particle-therapy-for-hepatocellular-carcinoma
#3
REVIEW
Hiroshi Igaki, Masashi Mizumoto, Toshiyuki Okumura, Kiyoshi Hasegawa, Norihiro Kokudo, Hideyuki Sakurai
Charged particle therapy (proton beam therapy and carbon ion therapy) is a form of radiotherapy which has the unique characteristic of superior depth dose distribution, and has been used for the treatment of hepatocellular carcinoma (HCC) in a limited number of patients, especially in Japan. We undertook a systematic review to define the clinical utility of charged particle therapy for patients with HCC. We searched the MEDLINE database from 1983 to June 2016 to identify clinical studies on charged particle therapy for HCC...
September 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28865201/session-55-irradiation-of-thoracic-tumours-in-particle-therapy-motion-and-modulation
#4
Christian Graeff
No abstract text is available yet for this article.
August 28, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28826292/radiobiological-issues-in-proton-therapy
#5
Radhe Mohan, Christopher R Peeler, Fada Guan, Lawrence Bronk, Wenhua Cao, David R Grosshans
The relative biological effectiveness (RBE) for particle therapy is a complex function of particle type, radiation dose, linear energy transfer (LET), cell type, endpoint, etc. In the clinical practice of proton therapy, the RBE is assumed to have a fixed value of 1.1. This assumption, along with the effects of physical uncertainties, may mean that the biologically effective dose distributions received by the patient may be significantly different from what is seen on treatment plans. This may contribute to unforeseen toxicities and/or failure to control the disease...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28810881/comparison-of-photon-volumetric-modulated-arc-therapy-intensity-modulated-proton-therapy-and-intensity-modulated-carbon-ion-therapy-for-delivery-of-hypo-fractionated-thoracic-radiotherapy
#6
Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan, Wen-Chien Hsi
PURPOSE: The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion therapy (IMCIT) in the delivery of hypo-fractionated thoracic radiotherapy. METHODS AND MATERIALS: Ten selected patients who underwent thoracic particle therapy between 2015 and 2016 were re-planned to receive a relative biological effectiveness (RBE) weighted dose of 60 Gy (i...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28762335/helium-ions-at-the-heidelberg-ion-beam-therapy-center-comparisons-between-fluka-monte-carlo-code-predictions-and-dosimetric-measurements
#7
T Tessonnier, A Mairani, S Brons, P Sala, F Cerutti, A Ferrari, T Haberer, J Debus, K Parodi
In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). Depth dose distributions in water with and without ripple filter, lateral profiles at different depths in water and a spread-out Bragg peak were investigated...
August 1, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28758407/radiation-for-skull-base-meningiomas-review-of-the-literature-on-the-approach-to-radiotherapy
#8
Fabio Y Moraes, Caroline Chung
Skull base meningiomas (SBM) pose unique challenges for radiotherapy as these tumors are often in close proximity to a number of critical structures and may not be surgically addressed in many cases, leaving the question about the tumor grade and expected biological behaviour. External beam radiotherapy and radiosurgery are longstanding treatments for meningioma that are typically used as upfront primary therapy, for recurrent tumors and as adjuvant therapy following surgical resection. There is controversy regarding the optimal timing and approach for radiation therapy in various clinical settings such as the role of adjuvant radiotherapy for completely resected grade 2 tumours...
July 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28741595/3d-range-modulator-for-scanned-particle-therapy-development-monte-carlo-simulations-and-experimental-evaluation
#9
Yuri Simeonov, Uli Weber, Petar Penchev, Toke Printz Ringbæk, Christoph Schuy, Stephan Brons, Rita Engenhart-Cabillic, Jens Bliedtner, Klemens Zink
The purpose of this work was to design and manufacture a 3D range-modulator for scanned particle therapy. The modulator is intended to create a highly conformal dose distribution with only one fixed energy, simultaneously reducing considerably the treatment time. As a proof of concept, a 3D range-modulator was developed for a spherical target volume with a diameter of 5 cm, placed at a depth of 25 cm in a water phantom. It consists of a large number of thin pins with a well-defined shape and different lengths to modulate the necessary shift of the Bragg peak...
August 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28727873/potential-of-prospective-particle-therapy-trials-to-increase-the-therapeutic-ratio-for-locally-advanced-lung-cancer
#10
Charles R Thomas
No abstract text is available yet for this article.
August 10, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28711189/effective-atomic-number-estimation-using-kv-mv-dual-energy-source-in-linac
#11
Dousatsu Sakata, Akihiro Haga, Satoshi Kida, Toshikazu Imae, Shigeharu Takenaka, Keiichi Nakagawa
Dual-energy computed tomography (DECT) imaging can measure the effective atomic number (EAN) as well as the electron density, and thus its adoption may improve dose calculations in brachytherapy and external photon/particle therapy. An expanded energy gap in dual-energy sources is expected to yield more accurate EAN estimations than conventional DECT systems, which typically span less than 100kV. The aim of this paper is to assess a larger energy gap DECT by using a linear accelerator (LINAC) radiotherapy system with a kV X-ray imaging device, which are combined to provide X-rays in both the kV- and MV-energy ranges...
July 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28676618/-iii-the-advantages-and-disadvantages-of-imrt-and-particle-therapy-for-prostate-cancer
#12
Katsumasa Nakamura, Kenta Konishi, Tetsuya Komatsu, Yoshiyuki Shioyama, Keiji Matsumoto
No abstract text is available yet for this article.
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28650846/dosimetric-verification-in-water-of-a-monte-carlo-treatment-planning-tool-for-proton-helium-carbon-and-oxygen-ion-beams-at-the-heidelberg-ion-beam-therapy-center
#13
T Tessonnier, T T Böhlen, F Ceruti, A Ferrari, P Sala, S Brons, T Haberer, J Debus, K Parodi, A Mairani
The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment of their dosimetric properties and by treatment planning comparisons with clinically used proton and carbon ion beams. In addition to the latter two ions, helium and oxygen ion beams are foreseen at the Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes in the near future. We present in this study a dosimetric validation of a FLUKA-based Monte Carlo treatment planning tool (MCTP) for protons, helium, carbon and oxygen ions for spread-out Bragg peaks in water...
July 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28635614/advanced-treatment-planning-using-direct-4d-optimisation-for-pencil-beam-scanned-particle-therapy
#14
Kinga Bernatowicz, Ye Zhang, Rosalind Perrin, Damien C Weber, Antony J Lomax
We report on development of a new four-dimensional (4D) optimisation approach for scanned proton beams, which incorporates both irregular motion patterns and the delivery dynamics of the treatment machine into the plan optimiser. Furthermore, we assess the effectiveness of this technique to reduce dose to critical structures in proximity to moving targets, while maintaining effective target dose homogeneity and coverage. The proposed approach has been tested using both a simulated phantom and a clinical liver cancer case, and allows for realistic 4D calculations and optimisation using irregular breathing patterns extracted from e...
July 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28562337/il13ra2-targeted-alpha-particle-therapy-against-glioblastomas
#15
Anirudh Sattiraju, Kiran Kumar Solingapuram Sai, Ang Xuan, Darpan N Pandya, Frankis G Almaguel, Thaddeus J Wadas, Denise M Herpai, Waldemar Debinski, Akiva Mintz
Glioblastoma (GBM) is the most aggressive primary malignant brain cancer that invariably results in a dismal prognosis. Chemotherapy and radiotherapy have not been completely effective as standard treatment options for patients due to recurrent disease. We and others have therefore developed molecular strategies to specifically target interleukin 13 receptor alpha 2 (IL13RA2), a GBM restricted receptor expressed abundantly on over 75% of GBM patients. In this work, we evaluated the potential of Pep-1L, a novel IL13RA2 targeted peptide, as a platform to deliver targeted lethal therapies to GBM...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28463156/particle-therapy-using-protons-or-carbon-ions-for-unresectable-or-incompletely-resected-bone-and-soft-tissue-sarcomas-of-the-pelvis
#16
Yusuke Demizu, Dongcun Jin, Nor Shazrina Sulaiman, Fumiko Nagano, Kazuki Terashima, Sunao Tokumaru, Takashi Akagi, Osamu Fujii, Takashi Daimon, Ryohei Sasaki, Nobukazu Fuwa, Tomoaki Okimoto
PURPOSE: To retrospectively analyze the treatment outcomes of particle therapy using protons or carbon ions for unresectable or incompletely resected bone and soft tissue sarcomas (BSTSs) of the pelvis. METHODS AND MATERIALS: From May 2005 to December 2014, 91 patients with nonmetastatic histologically proven unresectable or incompletely resected pelvic BSTSs underwent particle therapy with curative intent. The particle therapy used protons (52 patients) or carbon ions (39 patients)...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28378194/management-of-gbm-a-problem-of-local-recurrence
#17
REVIEW
John P Kirkpatrick, Nadia N Laack, Helen A Shih, Vinai Gondi
Forty years ago, adjuvant treatment of patients with GBM using fractionated radiotherapy following surgery was shown to substantially improve survival compared to surgery alone. However, even with the addition of temozolomide to radiotherapy, overall survival is quite limited and local failure remains a fundamental problem, despite multiple attempts to increase dose to the tumor target. This review presents the historical background and clinical rationale leading to the current standard of care consisting of 60 Gy total dose in 2 Gy fractions to the MRI-defined targets in younger, high performance status patients and more hypofractionated regimens in elderly and/or debilitated patients...
April 4, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28350543/mondo-a-neutron-tracker-for-particle-therapy-secondary-emission-characterisation
#18
M Marafini, L Gasparini, R Mirabelli, D Pinci, V Patera, A Sciubba, E Spiriti, D Stoppa, G Traini, A Sarti
Tumour control is performed in particle therapy using particles and ions, whose high irradiation precision enhances the effectiveness of the treatment, while sparing the healthy tissue surrounding the target volume. Dose range monitoring devices using photons and charged particles produced by the beam interacting with the patient's body have already been proposed, but no attempt has been made yet to exploit the detection of the abundant neutron component. Since neutrons can release a significant dose far away from the tumour region, precise measurements of their flux, production energy and angle distributions are eagerly sought in order to improve the treatment planning system (TPS) software...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28333688/treatment-planning-of-intensity-modulated-composite-particle-therapy-with-dose-and-linear-energy-transfer-optimization
#19
Taku Inaniwa, Nobuyuki Kanematsu, Koji Noda, Tadashi Kamada
The biological effect of charged-particle beams depends on both dose and particle spectrum. As one of the physical quantities describing the particle spectrum of charged-particle beams, we considered the linear energy transfer (LET) throughout this study. We investigated a new therapeutic technique using two or more ion species in one treatment session, which we call an intensity modulated composite particle therapy (IMPACT), for optimizing the physical dose and dose-averaged LET distributions in a patient as its proof of principle...
March 23, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28332993/are-treatment-toxicity-issues-in-particle-therapy-a-clarion-call-for-biologic-treatment-planning-overall
#20
Jeffrey C Buchsbaum
No abstract text is available yet for this article.
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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