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"particle therapy"

Giulia Marvaso, Barbara Vischioni, Barbara Alicja Jereczek-Fossa, Delia Ciardo, Piero Fossati, Tommaso Giandini, Sara Morlino, Mauro Carrara, Paola Romanelli, Elvio Russi, Francesca Valvo, Riccardo Valdagni, Roberto Orecchia
Hadrontherapy has been in constant progress in the past decades. Due to the increasing interest in this field and the spreading of the technique in Italy and worldwide, the Italian Society of Radiation Oncology surveyed (by an online survey) its members regarding their perception of hadrontherapy. The survey outline addressed different items all related to hadrontherapy, such as: demographics (3 items), personal knowledge (5 items), actual use in clinical practice (5 items), and future perspectives and development (5 items)...
October 21, 2016: La Radiologia Medica
Brent F B Huisman, J M Létang, É Testa, D Sarrut
There is interest in the particle therapy community in using prompt gammas (PGs), a natural byproduct of particle treatment, for range verification and eventually dose control. However, PG production is a rare process and therefore estimation of PGs exiting a patient during a proton treatment plan executed by a Monte Carlo (MC) simulation converges slowly. Recently, different approaches to accelerating the estimation of PG yield have been presented. Sterpin et al (2015 Phys. Med. Biol. 60 4915-46) described a fast analytic method, which is still sensitive to heterogeneities...
October 14, 2016: Physics in Medicine and Biology
Constantin Dreher, Christian Scholz, Mira Pommer, Stephan Brons, Hannah Prokesch, Swantje Ecker, Jürgen Debus, Oliver Jäkel, Stephanie E Combs, Daniel Habermehl
BACKGROUND: The aim of the thesis is to improve treatment plans of carbon ion irradiation by integrating the tissues' specific [Formula: see text]-values for patients with locally advanced pancreatic cancer (LAPC). MATERIAL AND METHODS: Five patients with LAPC were included in this study. By the use of the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) treatment plans with carbon ion beams have been created. Dose calculation was based on [Formula: see text]-values for both organs at risk (OAR) and the tumor...
2016: PloS One
Giulia Fontana, Marco Riboldi, Chiara Gianoli, Cezarina I Chirvase, Gaetano Villa, Chiara Paganelli, Paul E Summers, Barbara Tagaste, Andrea Pella, Piero Fossati, Mario Ciocca, Guido Baroni, Francesca Valvo, Roberto Orecchia
Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both in space, since the pancreas is located in proximity to radiosensitive vital organs, and in time as it is subject to substantial breathing-related motion. The purpose of this preliminary study was to quantify pancreas range of motion under typical PT treatment conditions. Three common immobilization devices (vacuum cushion, thermoplastic mask, and compressor belt) were evaluated on five male patients in prone and supine positions...
2016: Journal of Applied Clinical Medical Physics
J T Taylor, C Waltham, T Price, N M Allinson, P P Allport, G L Casse, A Kacperek, S Manger, N A Smith, I Tsurin
For many years, silicon micro-strip detectors have been successfully used as tracking detectors for particle and nuclear physics experiments. A new application of this technology is to the field of particle therapy where radiotherapy is carried out by use of charged particles such as protons or carbon ions. Such a treatment has been shown to have advantages over standard x-ray radiotherapy and as a result of this, many new centres offering particle therapy are currently under construction around the world today...
September 21, 2016: Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
D Chuard, V Anthonipillai, R Dendale, C Nauraye, E Khan, C Mabit, L De Marzi, L Narici
Particle therapy provides an opportunity to study the human response to space radiation in ground-based facilities. On this basis, a study of light flashes analogous to astronauts' phosphenes reported by patients undergoing ocular proton therapy has been undertaken. The influence of treatment parameters on phosphene generation was investigated for 430 patients treated for a choroidal melanoma at the proton therapy centre of the Institut Curie (ICPO) in Orsay, France, between 2008 and 2011. 60% of them report light flashes, which are predominantly (74%) blue...
August 2016: Life Sciences in Space Research
S Incerti, M Douglass, S Penfold, S Guatelli, E Bezak
Emerging radiotherapy treatments including targeted particle therapy, hadron therapy or radiosensitisation of cells by high-Z nanoparticles demand the theoretical determination of radiation track structure at the nanoscale. This is essential in order to evaluate radiation damage at the cellular and DNA level. Since 2007, Geant4 offers physics models to describe particle interactions in liquid water at the nanometre level through the Geant4-DNA Package. This package currently provides a complete set of models describing the event-by-event electromagnetic interactions of particles with liquid water, as well as developments for the modelling of water radiolysis...
September 19, 2016: Physica Medica: PM
Daniëlle B P Eekers, Erik Roelofs, Urszula Jelen, Maura Kirk, Marlies Granzier, Filippo Ammazzalorso, Peter H Ahn, Geert O R J Janssens, Frank J P Hoebers, Tobias Friedmann, Timothy Solberg, Sean Walsh, Esther G C Troost, Johannes H A M Kaanders, Philippe Lambin
BACKGROUND AND PURPOSE: In this multicentric in silico trial we compared photon, proton, and carbon-ion radiotherapy plans for re-irradiation of patients with squamous cell carcinoma of the head and neck (HNSCC) regarding dose to tumour and doses to surrounding organs at risk (OARs). MATERIAL AND METHODS: Twenty-five HNSCC patients with a second new or recurrent cancer after previous irradiation (70Gy) were included. Intensity-modulated proton therapy (IMPT) and ion therapy (IMIT) re-irradiation plans to a second subsequent dose of 70Gy were compared to photon therapy delivered with volumetric modulated arc therapy (VMAT)...
September 14, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Shin-Hyung Park, Jae-Chul Kim, Min Kyu Kang
Radiotherapy techniques have substantially improved in the last two decades. After the introduction of 3-dimensional conformal radiotherapy, radiotherapy has been increasingly used for the treatment of hepatocellular carcinoma (HCC). Currently, more advanced techniques, including intensity-modulated radiotherapy (IMRT), stereotactic ablative body radiotherapy (SABR), and charged particle therapy, are used for the treatment of HCC. IMRT can escalate the tumor dose while sparing the normal tissue even though the tumor is large or located near critical organs...
August 28, 2016: World Journal of Gastroenterology: WJG
A Schumann, M Priegnitz, S Schoene, W Enghardt, H Rohling, F Fiedler
Range verification and dose monitoring in proton therapy is considered as highly desirable. Different methods have been developed worldwide, like particle therapy positron emission tomography (PT-PET) and prompt gamma imaging (PGI). In general, these methods allow for a verification of the proton range. However, quantification of the dose from these measurements remains challenging. For the first time, we present an approach for estimating the dose from prompt γ-ray emission profiles. It combines a filtering procedure based on Gaussian-powerlaw convolution with an evolutionary algorithm...
October 7, 2016: Physics in Medicine and Biology
Vivek Verma, Steven H Lin, Charles B Simone, Minesh P Mehta
BACKGROUND: Proton beam radiotherapy (PBT) is frequently shown to be dosimetrically superior to photon radiotherapy (RT), though supporting data for clinical benefit are severely limited. Because of the potential for toxicity reduction in gastrointestinal (GI) malignancies, we systematically reviewed the literature on clinical outcomes (survival/toxicity) of PBT. METHODS: A systematic search of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology was conducted for publications from 2000-2015...
August 2016: Journal of Gastrointestinal Oncology
Marco Durante, Harald Paganetti
Charged particle therapy has been largely driven and influenced by nuclear physics. The increase in energy deposition density along the ion path in the body allows reducing the dose to normal tissues during radiotherapy compared to photons. Clinical results of particle therapy support the physical rationale for this treatment, but the method remains controversial because of the high cost and of the lack of comparative clinical trials proving the benefit compared to x-rays. Research in applied nuclear physics, including nuclear interactions, dosimetry, image guidance, range verification, novel accelerators and beam delivery technologies, can significantly improve the clinical outcome in particle therapy...
September 2016: Reports on Progress in Physics
Vivek Verma, Charles B Simone, Andrew O Wahl, Sushil Beriwal, Minesh P Mehta
BACKGROUND: Proton beam therapy (PBT) is increasingly being used globally to treat a variety of malignancies. This is the first review assessing PBT for gynecologic neoplasms. Dose distribution to organs-at-risk (OARs), particularly bone marrow (BM), is addressed. Clinical outcomes and toxicity data are detailed. MATERIAL AND METHODS: Systematic searches of PubMed, EMBASE, abstracts from meetings of the American Society for Radiation Oncology, Particle Therapy Co-Operative Group, and American Society of Clinical Oncology were conducted for publications...
November 2016: Acta Oncologica
Ivana Dokic, Andrea Mairani, Martin Niklas, Ferdinand Zimmermann, Naved Chaudhri, Damir Krunic, Thomas Tessonnier, Alfredo Ferrari, Katia Parodi, Oliver Jäkel, Jürgen Debus, Thomas Haberer, Amir Abdollahi
The growing number of particle therapy facilities worldwide landmarks a novel era of precision oncology. Implementation of robust biophysical readouts is urgently needed to assess the efficacy of different radiation qualities. This is the first report on biophysical evaluation of Monte Carlo simulated predictive models of prescribed dose for four particle qualities i.e., proton, helium-, carbon- or oxygen ions using raster-scanning technology and clinical therapy settings at HIT. A high level of agreement was found between the in silico simulations, the physical dosimetry and the clonogenic tumor cell survival...
August 1, 2016: Oncotarget
P Cambraia Lopes, J Bauer, A Salomon, I Rinaldi, V Tabacchini, T Tessonnier, P Crespo, K Parodi, D R Schaart
Positron emission tomography (PET) is the imaging modality most extensively tested for treatment monitoring in particle therapy. Optimal use of PET in proton therapy requires in situ acquisition of the relatively strong (15)O signal due to its relatively short half-life (~2 min) and high oxygen content in biological tissues, enabling shorter scans that are less sensitive to biological washout. This paper presents the first performance tests of a scaled-down in situ time-of-flight (TOF) PET system based on digital photon counters (DPCs) coupled to Cerium-doped Lutetium Yttrium Silicate (LYSO:Ce) crystals, providing quantitative results representative of a dual-head tomograph that complies with spatial constraints typically encountered in clinical practice (2  ×  50°, of 360°, transaxial angular acceptance)...
August 21, 2016: Physics in Medicine and Biology
David C Hansen, Thomas Sangild Sørensen, Simon Rit
Proton computed tomography (CT) has been demonstrated as a promising image modality in particle therapy planning. It can reduce errors in particle range calculations and consequently improve dose calculations. Obtaining a high imaging resolution has traditionally required computationally expensive iterative reconstruction techniques to account for the multiple scattering of the protons. Recently, techniques for direct reconstruction have been developed, but these require a higher imaging dose than the iterative methods...
August 7, 2016: Physics in Medicine and Biology
Makoto Sakama, Nobuyuki Kanematsu, Taku Inaniwa
A simple and efficient approach is needed for robustness evaluation and optimization of treatment planning in routine clinical particle therapy. Here we propose a robustness analysis method using dose standard deviation (SD) in possible scenarios such as the robustness indicator and a fast dose warping method, i.e. deformation of dose distributions, taking into account the setup and range errors in carbon-ion therapy. The dose warping method is based on the nominal dose distribution and the water-equivalent path length obtained from planning computed tomography data with a clinically commissioned treatment planning system (TPS)...
August 7, 2016: Physics in Medicine and Biology
Camilla H Stokkevåg, Mai Fukahori, Takuma Nomiya, Naruhiro Matsufuji, Grete May Engeseth, Liv B Hysing, Kristian S Ytre-Hauge, Eivind Rørvik, Artur Szostak, Ludvig P Muren
BACKGROUND AND PURPOSE: Radiation-induced cancer is a serious late effect that may follow radiotherapy. A considerable uncertainty is associated with carcinogenesis from photon-based treatment, and even less established when including relative biological effectiveness (RBE) for particle therapy. The aim of this work was therefore to estimate and in particular explore relative risks (RR) of secondary cancer (SC) following particle therapy as applied in treatment of prostate cancer. MATERIAL AND METHODS: RRs of radiation-induced SC in the bladder and rectum were estimated using a bell-shaped dose-response model incorporating RBE and fractionation effects...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
S K Patch, M Kireeff Covo, A Jackson, Y M Qadadha, K S Campbell, R A Albright, P Bloemhard, A P Donoghue, C R Siero, T L Gimpel, S M Small, B F Ninemire, M B Johnson, L Phair
The potential of particle therapy due to focused dose deposition in the Bragg peak has not yet been fully realized due to inaccuracies in range verification. The purpose of this work was to correlate the Bragg peak location with target structure, by overlaying the location of the Bragg peak onto a standard ultrasound image. Pulsed delivery of 50 MeV protons was accomplished by a fast chopper installed between the ion source and the cyclotron inflector. The chopper limited the train of bunches so that 2 Gy were delivered in [Formula: see text]...
August 7, 2016: Physics in Medicine and Biology
Slav Yartsev, Glenn Bauman
We review the literature on the use of margins in the radiotherapy of the prostate cancer patients, focusing on different options for image guidance and technical issues. The search in the PubMed database was limited to include studies that involved external beam radiotherapy of the intact prostate. Post-prostatectomy studies, brachytherapy, and particle therapy were excluded. Each article was characterized according to the employed image guidance strategy used: positioning on external marks using room lasers, bone anatomy and soft tissue match, usage of fiducial markers, electromagnetic tracking, and adapted delivery...
July 5, 2016: British Journal of Radiology
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