keyword
MENU ▼
Read by QxMD icon Read
search

"particle therapy"

keyword
https://www.readbyqxmd.com/read/29165322/treatment-planning-with-intensity-modulated-particle-therapy-for-multiple-targets-in-stage-iv-non-small-cell-lung-cancer
#1
Kristjan Anderle, Joep Stroom, Sandra Vieira, Nuno Pimentel, Carlo Greco, Marco Durante, Christian Graeff
Intensity modulated particle therapy (IMPT) can produce highly conformal plans, but is limited in advanced lung cancer patients with multiple lesions due to motion and planning complexity. A 4D IMPT optimization including all motion states was expanded to include multiple targets, where each target (isocenter) is designated to specific field(s). Furthermore, to achieve stereotactic treatment planning objectives, target and OAR weights plus objective doses were automatically iteratively adapted. Finally, 4D doses were calculated for different motion scenarios...
November 22, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29129050/metal-free-cycloaddition-chemistry-driven-pretargeted-radioimmunotherapy-using-%C3%AE-particle-radiation
#2
Manan Shah, Xiuli Zhang, Raffaella Rossin, Marc S Robillard, Darrell Fisher, Tyler Bueltmann, Freek J M Hoeben, Thomas Quinn
The pretargeted radioimmunotherapy approach (PRIT) decouples the administration of tumor targeting monoclonal antibodies (mAb) from that of the radiolabeled ligand. This multi-step strategy allows delivery of high doses of radiation to tumor cells while minimizing non-specific normal tissue irradiation. In this study, we evaluated the potential of pretargeted α-particle radioimmunotherapy based on inverse electron demand Diels-Alder reaction (IEDAA) between trans-cyclooctene (TCO) and tetrazine (Tz). Two tetrazine based chelators, DOTA-Tz and TCMC-Tz, were synthesized and compared for their radiolabeling efficiency with 212Pb, radiochemical stability and in-vivo pharmacokinetics...
November 12, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29114615/risk-of-carotid-blowout-after-reirradiation-with-particle-therapy
#3
Jon Espen Dale, Silvia Molinelli, Elisa Ciurlia, Mario Ciocca, Maria Bonora, Viviana Vitolo, Alfredo Mirandola, Stefania Russo, Roberto Orecchia, Olav Dahl, Piero Fossati
Purpose: Carotid blowout (CB) is a serious complication in retreatment of neoplasms in the head and neck (H&N) region. Rates seem to increase in hypofractionated or accelerated hyperfractionated regimens. In this study, we investigate the CB rate and the cumulative doses received by the carotid artery (CA) in a cohort of patients who were reirradiated at CNAO with particle therapy in the H&N region. Methods and materials: The dosimetric information, medical records, and tumor characteristics of 96 patients were analyzed...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29103987/special-radiobiological-features-of-second-cancer-risk-after-particle-radiotherapy
#4
Klaus-Rüdiger Trott
In absolute terms: second cancer risks from radiotherapy of first cancers in adults are small compared to the benefits from radiotherapy but this is not so for radiotherapy of childhood cancers. Moreover, the radiation dose dependence of cancer induction differs between organs and tissues. The organ-specific dose dependence of second cancer risks may indicate the existence of different radiobiological mechanisms. As an inevitable consequence of the age dependence of organ sensitivity to second cancer induction, the organ/tissue weighting factors which have been proposed by ICRP for calculating effective dose (the dose unit Sv) and for risk estimation in the general population should not be used in medical radiation exposures...
November 2, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29095996/optimum-size-of-a-calibration-phantom-for-x-ray-ct-to-convert-the-hounsfield-units-to-stopping-power-ratios-in-charged-particle-therapy-treatment-planning
#5
T Inaniwa, H Tashima, N Kanematsu
In charged-particle therapy treatment planning, the volumetric distribution of stopping power ratios (SPRs) of body tissues relative to water is used for patient dose calculation. The distribution is conventionally obtained from computed tomography (CT) images of a patient using predetermined conversion functions from the CT numbers to the SPRs. One of the biggest uncertainty sources of patient SPR estimation is insufficient correction of beam hardening arising from the mismatch between the size of the patient cross section and the calibration phantom for producing the conversion functions...
October 31, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/29092716/the-150-most-important-questions-in-cancer-research-and-clinical-oncology-series-questions-67-75-edited-by-chinese-journal-of-cancer
#6
EDITORIAL
(no author information available yet)
Since the beginning of 2017, Chinese Journal of Cancer has published a series of important questions in cancer research and clinical oncology, which sparkle diverse thoughts, interesting communications, and potential collaborations among researchers all over the world. In this article, 9 more questions are presented as followed. Question 67. How could we overcome the resistance of hepatocellular carcinoma against chemotherapeutics? Question 68. Is pursuit of non-covalent small-molecule binders of RAS proteins viable as a strategy of cancer drug discovery? Question 69...
November 1, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29080990/reirradiation-of-skull-base-tumors-with-advanced-highly-conformal-techniques
#7
REVIEW
Jennifer C Ho, Jack Phan
PURPOSE OF REVIEW: Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancements, such as image-guided radiation therapy (IGRT), intensity-modulated radiation therapy (IMRT), particle therapy, and stereotactic radiation therapy (SRT), are attractive for skull base reirradiation...
October 28, 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/29058267/robert-r-wilson-1914-2000-the-first-scientist-to-propose-particle-therapy-use-of-particle-beam-for-cancer-treatment
#8
EDITORIAL
Masahiro Endo
No abstract text is available yet for this article.
October 20, 2017: Radiological Physics and Technology
https://www.readbyqxmd.com/read/29050953/dual-energy-ct-based-proton-range-prediction-in-head-and-pelvic-tumor-patients
#9
Patrick Wohlfahrt, Christian Möhler, Kristin Stützer, Steffen Greilich, Christian Richter
BACKGROUND AND PURPOSE: To reduce range uncertainty in particle therapy, an accurate computation of stopping-power ratios (SPRs) based on computed tomography (CT) is crucial. Here, we assess range differences between the state-of-the-art CT-number-to-SPR conversion using a generic Hounsfield look-up table (HLUT) and a direct patient-specific SPR prediction (RhoSigma) based on dual-energy CT (DECT) in 100 proton treatment fields. MATERIAL AND METHODS: For 25 head-tumor and 25 prostate-cancer patients, the clinically applied treatment plan, optimized using a HLUT, was recalculated with RhoSigma as CT-number-to-SPR conversion...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29045700/prediction-model-of-critical-weight-loss-in-cancer-patients-during-particle-therapy
#10
Zhihong Zhang, Y Zhu, Lijuan Zhang, Ziying Wang, Hongwei Wan
Background and purpose: The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods: Patients receiving particle therapy were enroled between June 2015 and June 2016. Body weight was measured at the start and end of particle therapy. Association between critical weight loss (defined as >5%) during particle therapy and patients' demographic, clinical characteristic, pre-therapeutic nutrition risk screening (NRS 2002) and BMI were evaluated by logistic regression and decision tree analysis...
October 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28993729/differential-impact-of-single-dose-fe-ion-and-x-ray-irradiation-on-endothelial-cell-transcriptomic-and-proteomic-responses
#11
Bjorn Baselet, Omid Azimzadeh, Nadine Erbeldinger, Mayur V Bakshi, Till Dettmering, Ann Janssen, Svetlana Ktitareva, Donna J Lowe, Arlette Michaux, Roel Quintens, Kenneth Raj, Marco Durante, Claudia Fournier, Mohammed A Benotmane, Sarah Baatout, Pierre Sonveaux, Soile Tapio, An Aerts
Background and Purpose: Radiotherapy is an essential tool for cancer treatment. In order to spare normal tissues and to reduce the risk of normal tissue complications, particle therapy is a method of choice. Although a large part of healthy tissues can be spared due to improved depth dose characteristics, little is known about the biological and molecular mechanisms altered after particle irradiation in healthy tissues. Elucidation of these effects is also required in the context of long term space flights, as particle radiation is the main contributor to the radiation effects observed in space...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28980974/analytical-probabilistic-modeling-of-rbe-weighted-dose-for-ion-therapy
#12
Hans-Peter Wieser, Philipp Hennig, Niklas Wahl, Mark Bangert
Particle therapy is especially prone to uncertainties. This issue is usually being addressed with uncertainty quantification and minimization techniques based on scenario sampling. For proton therapy, however, it was recently shown that it is also possible to use closed-form computations based on Analytical Probabilistic Modeling (APM) for this purpose. APM yields unique features compared to sampling-based approaches motivating further research in this context. This paper demonstrates the application of APM for intensity-modulated carbon ion therapy to quantify the influence of setup and range uncertainties on the RBE-weighted dose...
October 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28978247/effective-atomic-number-of-soft-tissue-water-and-air-for-interaction-of-various-hadrons-leptons-and-isotopes-of-hydrogen
#13
Murat Kurudirek
PURPOSE: Characterization of soft tissue, water and air in terms of effective atomic number (Zeff) with respect to the interactions of hadrons, leptons and isotopes of hydrogen. METHOD: Mass collision stopping powers (MCSPs) were calculated first using Bethe formula. Then, these values were used to estimate Zeff using linear-logarithmic interpolation. A scale equation was also used to calculate MCSP. RESULTS: Variation in Zeff, over the 0...
November 2, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28975835/role-and-future-directions-of-external-beam-radiotherapy-for-primary-liver-cancer
#14
Florence K Keane, Theodore S Hong
The incidence of primary liver cancers continues to increase in the United States and worldwide. The majority of patients with primary liver cancer are not candidates for curative therapies such as surgical resection or orthotopic liver transplantation due to tumor size, vascular invasion, or underlying comorbidities. Therefore, while primary liver cancer is the sixth-most common cancer diagnosis worldwide, it represents the second leading cause of cancer-related deaths. Radiotherapy traditionally played a limited role in the treatment of primary liver cancer due to concerns over hepatic tolerance and the inability to deliver a tumoricidal dose of radiotherapy while still sparing normal hepatic parenchyma...
July 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28943076/evidence-based-review-on-the-use-of-proton-therapy-in-lymphoma-from-the-particle-therapy-cooperative-group-ptcog-lymphoma-subcommittee
#15
REVIEW
Yolanda D Tseng, David J Cutter, John P Plastaras, Rahul R Parikh, Oren Cahlon, Michael D Chuong, Katerina Dedeckova, Mohammad K Khan, Shinn-Yn Lin, Lisa A McGee, Eric Yi-Liang Shen, Stephanie A Terezakis, Shahed N Badiyan, Youlia M Kirova, Richard T Hoppe, Nancy P Mendenhall, Mark Pankuch, Stella Flampouri, Umberto Ricardi, Bradford S Hoppe
No abstract text is available yet for this article.
November 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28924096/revision-of-calibration-method-of-ct-number-to-stopping-power-ratio-conversion-for-treatment-planning-of-particle-therapy
#16
Nobuyuki Kanematsu, Shinichiro Mori, Taku Inaniwa
A calibration method for CT-number to stopping-power-ratio conversion was recently proposed as a revision of the Japanese de facto standard method that has been used at particle therapy centers in Japan for over a decade. The revised method deals with 11 representative tissues of specific elemental composition and density, based on a latest compilation of standard tissue data. We report here how the revision was actually implemented into clinical practice. We applied the revised method to 7 CT-scanning conditions currently in use for treatment planning...
2017: Japanese Journal of Medical Physics
https://www.readbyqxmd.com/read/28886211/homogeneity-study-of-proton-and-carbon-ion-scanning-beams-using-combinations-of-different-spot-sizes-and-grid-sizes
#17
Ying Xing, Xianwei Wu, Yongqiang Li, Jun Zhao
PURPOSE: Different scanning ion beam delivery systems have different delivery accuracies, and the resulting delivery errors will affect field homogeneity. This study was performed to determine an appropriate combination of spot size (FWHM) and spot grid size (GS), which can provide homogenous dose distributions for both proton and carbon ion scanning beam radiotherapy. The combination of the two parameters is represented by a combination factor named n, which is the quotient of FWHM divided by GS...
September 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28871342/a-systematic-review-of-publications-on-charged-particle-therapy-for-hepatocellular-carcinoma
#18
REVIEW
Hiroshi Igaki, Masashi Mizumoto, Toshiyuki Okumura, Kiyoshi Hasegawa, Norihiro Kokudo, Hideyuki Sakurai
Charged particle therapy (proton beam therapy and carbon ion therapy) is a form of radiotherapy which has the unique characteristic of superior depth dose distribution, and has been used for the treatment of hepatocellular carcinoma (HCC) in a limited number of patients, especially in Japan. We undertook a systematic review to define the clinical utility of charged particle therapy for patients with HCC. We searched the MEDLINE database from 1983 to June 2016 to identify clinical studies on charged particle therapy for HCC...
September 4, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28865201/session-55-irradiation-of-thoracic-tumours-in-particle-therapy-motion-and-modulation
#19
Christian Graeff
No abstract text is available yet for this article.
August 28, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28826292/radiobiological-issues-in-proton-therapy
#20
Radhe Mohan, Christopher R Peeler, Fada Guan, Lawrence Bronk, Wenhua Cao, David R Grosshans
The relative biological effectiveness (RBE) for particle therapy is a complex function of particle type, radiation dose, linear energy transfer (LET), cell type, endpoint, etc. In the clinical practice of proton therapy, the RBE is assumed to have a fixed value of 1.1. This assumption, along with the effects of physical uncertainties, may mean that the biologically effective dose distributions received by the patient may be significantly different from what is seen on treatment plans. This may contribute to unforeseen toxicities and/or failure to control the disease...
November 2017: Acta Oncologica
keyword
keyword
73580
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"