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https://www.readbyqxmd.com/read/29768612/the-incidence-of-sexual-violence-among-children-and-adolescents-in-recife-state-of-pernambuco-brazil-in-2012-and-2013
#1
Cláudia Alves de Sena, Maria Arleide da Silva, Gilliatt Hanois Falbo Neto
The scope of this study was to establish the incidence of sexual violence against children and adolescents in Recife, State of Pernambuco (Brazil) between 2012 and 2013. Data was collected from the records of rape examination reports carried out at the Recife Institute of Forensic Medicine. Of the 867 cases recorded, 328 of the victims were children and adolescents. An incidence of 3.67 cases per 10,000 inhabitants in the 0 to 18 age range was identified. The majority of the victims were female (92.1%) between 10 and 14 years of age (59...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29760822/influence-of-lateral-cephalometric-radiographs-on-orthodontic-treatment-planning-of-class-ii-patients
#2
Irina Stupar, Enver Yetkiner, Daniel Wiedemeier, Thomas Attin, Rengin Attin
Background: Lateral Cephalometric Radiographs (LCR) are a common decision-making aid in orthodontic treatment planning and are routinely used in clinical practice. The aim of this present study was to test the null hypothesis that LCR evaluation does not alter specific components of orthodontic treatment planning in Class II patients. Materials and Methods: Records of 75 patients, who had been treated at the Department of Orthodontics, Centre of Dental Medicine, University of Zurich comprised the study material...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29759018/accelerating-pediatric-cancer-drug-development-challenges-and-opportunities-for-pediatric-master-protocols
#3
Tahira Khan, Mark Stewart, Samuel Blackman, Raphaël Rousseau, Martha Donoghue, Kenneth Cohen, Nita Seibel, Mark Fleury, Bouchra Benettaib, Raleigh Malik, Gilles Vassal, Gregory Reaman
Although outcomes for children with cancer have significantly improved over the past 40 years, there has been little progress in the treatment of some pediatric cancers, particularly when advanced. Additionally, clinical trial options and availability are often insufficient. Improved genomic and immunologic understanding of pediatric cancers, combined with innovative clinical trial designs, may provide an enhanced opportunity to study childhood cancers. Master protocols, which incorporate the use of precision medicine approaches, coupled with the ability to quickly assess the safety and effectiveness of new therapies, have the potential to accelerate early-phase clinical testing of novel therapeutics and which may result in more rapid approval of new drugs for children with cancer...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29758564/monogenic-diabetes-in-overweight-and-obese-youth-diagnosed-with-type-2-diabetes-the-today-clinical-trial
#4
Jeffrey W Kleinberger, Kenneth C Copeland, Rachelle G Gandica, Morey W Haymond, Lynne L Levitsky, Barbara Linder, Alan R Shuldiner, Sherida Tollefsen, Neil H White, Toni I Pollin
PurposeMonogenic diabetes accounts for 1-2% of diabetes cases. It is often undiagnosed, which may lead to inappropriate treatment. This study was performed to estimate the prevalence of monogenic diabetes in a cohort of overweight/obese adolescents diagnosed with type 2 diabetes (T2D).MethodsSequencing using a custom monogenic diabetes gene panel was performed on a racially/ethnically diverse cohort of 488 overweight/obese adolescents with T2D in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial...
October 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29748452/influence-of-allergic-rhinitis-in-children-and-adolescents-with-recurrent-headache
#5
Francesco Maria Passali, Maria Carla Spinosi, Giulia Mignacco, Cemal Cingi, Hugo Anibal Rodriguez, Desiderio Passali
INTRODUCTION: Migraine and allergies are a common occurrence. The aim of this study was to investigate the relationship between respiratory allergy and migraine in childhood. MATERIALS AND METHODS: We screened 800 children for headache and its characteristics. After that we investigated the presence of allergy performing prick tests, rhinoscopy, endoscopy, rhinomanometry, cytology and mucociliary clearance tests. RESULTS: Out of 800 children screened, 96 suffered from headache...
April 30, 2018: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29735880/-the-effects-of-neurofeedback-training-on-physical-psychoemotional-stress-response-and-self-regulation-for-late-adolescence-a-non-randomized-trial
#6
Moon Ji Choi, Wan Ju Park
PURPOSE: The aim of this study was to analyze the effects of neurofeedback training for reducing stress and enhancing self-regulation in late adolescence to identify the possibility of use for nursing intervention. METHODS: A nonequivalent control group pre-post quasi-experimental design was used. Participants were 78 late adolescents assigned to the experimental group (n=39) that received the neurofeedback training and the control group (n=39). Data were collected on heart rate variability (HRV) and skin conductance level (SCL) to assess stress-biomarker response...
April 2018: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29735135/diagnosis-of-spondylolysis-and-spondylolisthesis-is-delayed-six-months-after-seeing-nonorthopedic-providers
#7
Ena Nielsen, Lindsay M Andras, David L Skaggs
STUDY DESIGN: Retrospective single center. OBJECTIVE: Our purpose was to quantify the time to diagnosis of spondylolysis/spondylolisthesis in symptomatic patients after first seeking medical care. SUMMARY OF BACKGROUND DATA: Several studies have found a high prevalence of pars defects in adolescent athletes with back pain, up to 47%. A review by the Scoliosis Research Society Evidence-Based Medicine Committee reports that both nonsurgical and surgical treatment of symptomatic spondylolysis effectively relieves pain and allows most patients to return to activities...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29726749/international-variation-in-programmes-for-assessment-of-children-s-neurodevelopment-in-the-community-understanding-disparate-approaches-to-evaluation-of-motor-social-emotional-behavioural-and-cognitive-function
#8
Philip Wilson, Rachael Wood, Kirsten Lykke, Anette Hauskov Graungaard, Ruth Kirk Ertmann, Merethe Kirstine Andersen, Ole Rikard Haavet, Per Lagerløv, Eirik Abildsnes, Mina P Dahli, Marjukka Mäkelä, Aleksi Varinen, Merja Hietanen
BACKGROUND: Few areas of medicine demonstrate such international divergence as child development screening and surveillance. Many countries have nationally mandated surveillance policies, but the content of programmes and mechanisms for delivery vary enormously. The cost of programmes is substantial but no economic evaluations have been carried out. We have critically examined the history, underlying philosophy, content and delivery of programmes for child development assessment in five countries with comprehensive publicly funded health services (Denmark, Finland, Norway, Scotland and Sweden)...
May 1, 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29718649/synthetic-drug-intoxication-in-children-recognition-and-management-in-the-emergency-department-digest
#9
Rahul Shah, Carl R Baum, Kathryn H Pade
When children and adolescents present to the emergency department with agitation or mental status changes, intoxication from synthetic drug use should be in the differential diagnosis. Identifying the responsible compound(s) may be difficult, so asking the patient broad questions and utilizing appropriate diagnostic studies, when indicated, will aid in making the diagnosis and help identify more-serious complications. This issue discusses the challenges presented by the changing chemical formulations of synthetic cannabinoids, cathinones, and phenethylamines; outlines common presentations of intoxication from these substances; and summarizes best practices for evaluating and managing patients who present with intoxication after consumption of these synthetic drugs of abuse...
May 1, 2018: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/29703226/individualised-short-term-therapy-for-adolescents-impaired-by-attention-deficit-hyperactivity-disorder-despite-previous-routine-care-treatment-escaadol-study-protocol-of-a-randomised-controlled-trial-within-the-consortium-escalife
#10
Julia Geissler, Thomas Jans, Tobias Banaschewski, Katja Becker, Tobias Renner, Daniel Brandeis, Manfred Döpfner, Christina Dose, Christopher Hautmann, Martin Holtmann, Carolin Jenkner, Sabina Millenet, Marcel Romanos
BACKGROUND: Despite the high persistence rate of attention-deficit/hyperactivity disorder (ADHD) throughout the lifespan, there is a considerable gap in knowledge regarding effective treatment strategies for adolescents with ADHD. This group in particular often shows substantial psychosocial impairment, low compliance and insufficient response to psychopharmacological interventions. Effective and feasible treatments should further consider the developmental shift in ADHD symptoms, comorbidity and psychosocial adversity as well as family dysfunction...
April 27, 2018: Trials
https://www.readbyqxmd.com/read/29699772/review-and-application-of-the-national-academies-of-sciences-engineering-and-medicine-bullying-or-cyberbullying-recommendations-for-screening-and-lesbian-gay-bisexual-and-transgender-youth
#11
Gordon Lee Gillespie, Danny G Willis, Angela F Amar
BACKGROUND: Bullying has been long seen as a natural part of childhood and adolescence. However, a growing body of evidence suggests bullying and now cyberbullying may inflict harm or distress on targeted youth including physical, psychological, social, or educational harm. PURPOSE: The purpose of this paper is to endorse the National Academies of Sciences, Engineering, and Medicine statement, summarize the report, and apply the recommendations to two focus areas: screening and lesbian, gay, bisexual, and transgender youth as they relate to bullying and cyberbullying...
March 8, 2018: Nursing Outlook
https://www.readbyqxmd.com/read/29695885/post-earthquake-health-service-support-nepal
#12
Sophie Goyet, Rajan Rayamajhi, Badry Nath Gyawali, Bhola Ram Shrestha, Guna Raj Lohani, Damodar Adhikari, Edwin Salvador, Roderico Ofrin, Jos Vandelaer, Reuben Samuel
Problem: Seven months after the April 2015 Nepal earthquake, and as relief efforts were scaling down, health authorities faced ongoing challenges in health-service provision and disease surveillance reporting. Approach: In January 2016, the World Health Organization recruited and trained 12 Nepalese medical doctors to provide technical assistance to the health authorities in the most affected districts by the earthquake. These emergency support officers monitored the recovery of health services and reconstruction of health facilities, monitored stocks of essential medicines, facilitated disease surveillance reporting to the health ministry and assisted in outbreak investigations...
April 1, 2018: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29693461/an-update-on-pharmacotherapy-of-autism-spectrum-disorder-in-children-and-adolescents
#13
Ritu Goel, Ji Su Hong, Robert L Findling, Na Young Ji
To date, no medication is proven to be effective in treating core symptoms of autism spectrum disorder (ASD). Psychotropic medications are widely used to target emotional and behavioural symptoms in ASD. This article reviewed evidence for pharmacotherapy, novel therapeutic agents, and Complementary and Alternative Medicine (CAM) in children and adolescents with ASD. Currently, only risperidone and aripiprazole have been approved by the US Food and Drug Administration (FDA) for treatment of irritability associated with ASD in children and adolescents...
April 25, 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29686145/interpretation-of-do-not-attempt-resuscitation-orders-for-children-requiring-anesthesia-and-surgery
#14
Mary E Fallat, Courtney Hardy
This clinical report addresses the topic of pre-existing do not attempt resuscitation or limited resuscitation orders for children and adolescents undergoing anesthesia and surgery. Pertinent considerations for the clinician include the rights of children, decision-making by parents or legally approved representatives, the process of informed consent, and the roles of surgeon and anesthesiologist. A process of re-evaluation of the do not attempt resuscitation orders, called "required reconsideration," should be incorporated into the process of informed consent for surgery and anesthesia, distinguishing between goal-directed and procedure-directed approaches...
April 23, 2018: Pediatrics
https://www.readbyqxmd.com/read/29669353/cinobufagin-induces-apoptosis-in-osteosarcoma-cells-via-the-mitochondria-mediated-apoptotic-pathway
#15
Guo Dai, Di Zheng, Weichun Guo, Jian Yang, An-Yuan Cheng
BACKGROUND/AIMS: Osteosarcoma is a common primary malignant bone tumor that mainly occurs in childhood and adolescence. Despite developments in the diagnosis and treatment of osteosarcoma, the prognosis is still very poor. Cinobufagin is an active component in the anti-tumor Chinese medicine called "Chan Su", and we previously revealed that cinobufagin induced apoptosis and reduced the viability of osteosarcoma cells; however, the underlying mechanism remains to be elucidated...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29659684/%C3%AF-3-fatty-acids-impaired-fetal-growth-and-cardiovascular-risk-nutrition-as-precision-medicine
#16
Michael R Skilton
Precision medicine refers to treatment or prevention strategies in a group of individuals identified by their phenotype or genotype. Dietary components or patterns may play an important role in precision medicine. There is emerging evidence to support a role for n-3 (ω-3) fatty acids in lowering blood pressure and reducing the extent of subclinical atherosclerosis in people born with impaired fetal growth, a group at increased risk of coronary artery disease partly due to an increased risk of hypertensive disorders...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29659639/-preventive-dentistry-10-erosive-tooth-wear
#17
M C D N J M Huysmans
Erosive tooth wear has recently been at the centre of attention and its prevalence of erosive tooth wear among adolescents in the Netherlands appears to be rising. The multifactorial nature of the aetiology of the condition makes it difficult to identify the relevant causal factors, both in individual cases and within the general population. Preventive intervention is indicated in those cases where (active) erosive tooth wear is diagnosed. Early diagnosis is important, especially in younger patients. Preventive measures, such as dietary advice and the use of fluoride, are recommended but the scientific evidence for their effectiveness is still limited...
April 2018: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29659203/a-qualitative-study-to-assess-how-primary-care-versus-psychiatric-providers-evaluate-and-treat-pediatric-patients-with-irritability
#18
Anna L Scandinaro, Usman Hameed, Cheryl A Dellasega
Objective: To determine how primary care versus specialist practitioners assess and treat school-aged children with irritability. Methods: Seventeen providers from family medicine, pediatrics, and psychiatry participated in in-depth interviews from June to August 2016 about the process they use to evaluate irritability. Data on demographic traits and measures of confidence were also collected. Results: Primary care (family medicine and pediatrics) participants expressed frustration over the lack of time and specialized knowledge they had to accurately assess children with irritability, even though they were often the first clinician consulted when problems arose...
April 5, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29658377/the-use-of-the-newest-vital-sign-health-literacy-instrument-in-adolescents-with-sickle-cell-disease
#19
Elizabeth Perry Caldwell, Patricia Carter, Heather Becker, Michael Mackert
The purpose of this article is to discuss the use of the Newest Vital Sign (NVS) health literacy instrument in adolescents with sickle cell disease. The NVS evaluates both literacy and numeracy (the ability to understand and work with numbers) as well as the ability to locate and apply information. It is important to validate the NVS for use in adolescents, as the only currently validated instrument, the Rapid Estimate of Adolescent Literacy in Medicine-Teen (REALM-Teen), does not measure numeracy or the ability to locate or apply information...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29651961/the-benefit-of-prescribing-vitamin-d-as-add-on-therapy-on-the-electrocardiographic-changes-in-epileptic-patients
#20
Marwan S M Al-Nimer
BACKGROUND: Epileptic children and adolescent have a significantly low serum level of vitamin D due to the effect of antiepileptic drugs on the vitamin D metabolism. Those patients are at risk of cardiovascular events. OBJECTIVE: This study aimed to show that epileptic patients who treated with antiepileptic drugs supplemented with vitamin D are free from the electrocardiograph changes compared with those treated with antiepileptic drugs. METHOD: This cross-sectional study included, 121 epileptic patients aged < 18 years of both genders with a history of idiopathic generalized tonic clonic seizure...
April 12, 2018: Current Clinical Pharmacology
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