keyword
MENU ▼
Read by QxMD icon Read
search

Cell adhesion

keyword
https://www.readbyqxmd.com/read/28212546/precursor-n-cadherin-mediates-glial-cell-line-derived-neurotrophic-factor-promoted-human-malignant-glioma
#1
Ye Xiong, Liyun Liu, Shuang Zhu, Baole Zhang, Yuxia Qin, Ruiqin Yao, Hao Zhou, Dian Shuai Gao
As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved is unclear. In this study, we affirm a significantly higher expression of the precursor of N-cadherin (proN-cadherin) in most gliomas compared with normal brain tissues. Our findings reveal that GDNF interacts with the extracellular domain of proN-cadherin, which suggests that proN-cadherin mediates GDNF-induced glioma cell migration and invasion...
February 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212280/biofilm-formation-and-immunomodulatory-activity-of-proteus-mirabilis-clinically-isolated-strains
#2
Alessandra Fusco, Lorena Coretti, Vittoria Savio, Elisabetta Buommino, Francesca Lembo, Giovanna Donnarumma
Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors able to promote adhesion and biofilm formation and ameliorate the colonization of urinary tract and the formation of crystalline biofilms on the abiotic surface of the urinary catheters. Since, to date, the role of P. mirabilis in the etiopathogenesis of different types of urinary tract infections is not well established, in this study we sought to characterize two different clinically isolated strains of P...
February 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28211911/three-dimensional-printing-of-calcium-sulfate-and-mesoporous-bioactive-glass-scaffolds-for-improving-bone-regeneration-in-vitro-and-in-vivo
#3
Xin Qi, Peng Pei, Min Zhu, Xiaoyu Du, Chen Xin, Shichang Zhao, Xiaolin Li, Yufang Zhu
In the clinic, bone defects resulting from infections, trauma, surgical resection and genetic malformations remain a significant challenge. In the field of bone tissue engineering, three-dimensional (3D) scaffolds are promising for the treatment of bone defects. In this study, calcium sulfate hydrate (CSH)/mesoporous bioactive glass (MBG) scaffolds were successfully fabricated using a 3D printing technique, which had a regular and uniform square macroporous structure, high porosity and excellent apatite mineralization ability...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211801/effect-of-shear-induced-platelet-activation-on-red-blood-cell-aggregation
#4
Hoyoon Lee, Kisung Lee, Byoung-Kwon Lee, Alexander V Priezzhev, Sehyun Shin
Mechanical shear stress is one of the important factors for platelet activation. Although shear stress has been frequently utilized in many applications of diagnostic bio-equipment, there has been little consideration as to whether shear stress induces platelet activation and consequently alters hemorheological characteristics. Therefore, we investigated the effect of shear-induced platelet activation on red blood cell (RBC) aggregation. The hypothesis of the present research is as follows: Platelets activated by high shear stress secrete substances, which can affect hemorheological characteristics to promote RBC aggregation...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28211799/increased-expression-of-long-non-coding-rna-glidr-in-prostate-cancer
#5
Yingyi Zhang, Zhe Kong, Yalong Zhang, Wenhua Huang, Hai Wu, Xuechao Wan, Yao Li
Prostate cancer (PCa) was one of the most common cancers in males in China. Long non-coding RNAs (lncRNA), a class of non-coding RNAs with more than 200 nucleotides, played key roles in the progression of prostate cancer. GLIDR, a novel long intergenic ncRNA, was found to be upregulated in tumors compared to normal tissues by using publically databases. In the clinical validation cohort, our results showed GLIDR was significantly up-regulated in prostate cancer samples and cell lines. To explore the potential functions of the GLIDR, we constructed gene co-expression networks and applied GO analysis...
February 3, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28211702/antimicrobial-effect-of-biocompatible-silicon-nanoparticles-activated-by-therapeutic-ultrasound
#6
Svetlana N Shevchenko, Markus Burkhardt, Eugene V Sheval, Ulyana A Natashina, Christina Große, Alexander L Nikolaev, Alexander V Gopin, Ute Neugebauer, Andrew A Kudryavtsev, Vladimir Sivakov, Liubov Andreevna Osminkina
In this study, we report on a method for suppressing of Escherichia coli (E.coli) vitality by means of therapeutic ultrasound irradiation (USI) using biocompatible silicon nanoparticles as cavitation sensitizers. Silicon nanoparticles without (SiNPs) and with polysaccharide (dextran) coating (DSiNPs) were used. Both types of nanoparticles were non-toxic to Hep 2 cells up to concentration of 2 mg/ml. The treatment of bacteria with nanoparticles and application of 1 W/cm2 USI resulted in reduction of their viability up to 35% and 72% for SiNPs and DSiNPs, respectively...
February 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28211615/targeting-of-crosstalk-between-tumor-and-tumor-microenvironment-by-%C3%AE-d-mannuronic-acid-m2000-in-murine-breast-cancer-model
#7
Fatemeh Hosseini, Hadi Hassannia, Ahmad Mahdian-Shakib, Farhad Jadidi-Niaragh, Seyedehsan Enderami, Mohammadjavad Fattahi, Ali Anissian, Abbas Mirshafiey, Parviz Kokhaei
Metastasis is the main cause of death in breast cancer patients. Inflammatory processes following crosstalk between tumor cells and tumor microenvironment play an important role in progression and metastasis of cancer. Hence, targeting of these interactions may represent a novel promising strategy for breast cancer therapy. So, we investigated the effects of β-D mannuronic acid (BDM), a new antiinflammatory agent, on 4T1 breast cancer cell line both in vitro and in vivo. Proliferation assays revealed low-cytotoxic effect of BDM on 4T1 cells...
February 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28211475/biofilm-formation-of-the-black-yeast-like-fungus-exophiala-dermatitidis-and-its-susceptibility-to-antiinfective-agents
#8
Lisa Kirchhoff, Maike Olsowski, Katrin Zilmans, Silke Dittmer, Gerhard Haase, Ludwig Sedlacek, Eike Steinmann, Jan Buer, Peter-Michael Rath, Joerg Steinmann
Various fungi have the ability to colonize surfaces and to form biofilms. Fungal biofilm-associated infections are frequently refractory to targeted treatment because of resistance to antifungal drugs. One fungus that frequently colonises the respiratory tract of cystic fibrosis (CF) patients is the opportunistic black yeast-like fungus Exophiala dermatitidis. We investigated the biofilm-forming ability of E. dermatitidis and its susceptibility to various antiinfective agents and natural compounds. We tested 58 E...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211364/antibacterial-effect-of-novel-biodegradable-and-bioresorbable-plda-mg-composites
#9
M C Fernández-Calderón, S C Cifuentes, M A Pacha-Olivenza, A M Gallardo-Moreno, L Saldaña, J L González-Carrasco, M T Blanco, N Vilaboa, M L González-Martín, C Pérez-Giraldo
Polylactic acid/Mg composites have been recently proposed for biodegradable osteosynthesis devices because, with regards to the neat polymer, they combine an enhanced biocompatibility and bioactivity with better mechanical properties, particularly creep strength. A question still arises about their bacterial behavior. For this purpose, composites of poly-L-D-lactic acid (PLDA) loaded with 1 and 10 wt.% of Mg microparticles were evaluated using Staphylococcus epidermidis, with special emphasis on the study of bacterial adhesion and biofilm formation...
February 17, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28211187/deletion-of-junctional-adhesion-molecule-a-from-platelets-increases-early-stage-neointima-formation-after-wire-injury-in-hyperlipidemic-mice
#10
Zhen Zhao, Tanja Vajen, Ela Karshovska, Annemiek Dickhout, Martin M Schmitt, Remco T A Megens, Philipp von Hundelshausen, Thomas A Koeppel, Tilman M Hackeng, Christian Weber, Rory R Koenen
Platelets play an important role in the pathogenesis of vascular remodelling after injury. Junctional adhesion molecule A (JAM-A) was recently described to regulate platelet activation. Specific deletion of JAM-A from platelets resulted in increased reactivity and in accelerated progression of atherosclerosis. The aim of this study was to investigate the specific contribution of platelet-derived JAM-A to neointima formation after vascular injury. Mice with or without platelet-specific (tr)JAM-A-deficiency in an apolipoprotein e (apoe(-/-) ) background underwent wire-induced injury of the common carotid artery...
February 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28211055/pemphigus-a-pathomechanism-of-acantholysis
#11
REVIEW
Masutaka Furue, Takafumi Kadono
Autoantibodies to the desmosomal proteins desmoglein 1 and 3 cause pemphigus foliaceus and pemphigus vulgaris, which are characterised by keratinocyte dissociation (acantholysis) and intraepidermal blister formation. The passive transfer of pathogenic anti-desmoglein antibodies induces blisters in mice in vivo and the loss of keratinocyte adhesion in vitro. The pathogenetic mechanisms of acantholysis due to anti-desmoglein autoantibodies are not fully understood. However, recent studies have revealed that signalling-dependent and signalling-independent pathways are operative in the loss of cell adhesion...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28210256/transcriptomic-analysis-of-the-innate-antiviral-immune-response-in-porcine-intestinal-epithelial-cells-influence-of-immunobiotic-lactobacilli
#12
Leonardo Albarracin, Hisakazu Kobayashi, Hikaru Iida, Nana Sato, Tomonori Nochi, Hisashi Aso, Susana Salva, Susana Alvarez, Haruki Kitazawa, Julio Villena
Lactobacillus rhamnosus CRL1505 and Lactobacillus plantarum CRL1506 are immunobiotic strains able to increase protection against viral intestinal infections as demonstrated in animal models and humans. To gain insight into the host-immunobiotic interaction, the transcriptomic response of porcine intestinal epithelial (PIE) cells to the challenge with viral molecular associated pattern poly(I:C) and the changes in the transcriptomic profile induced by the immunobiotics strains CRL1505 and CRL1506 were investigated in this work...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28209985/ig-like-domain-6-of-vcam-1-is-a-potential-therapeutic-target-in-tnf%C3%AE-induced-angiogenesis
#13
Taek-Keun Kim, Chang Sik Park, Hee-Jun Na, Kangseung Lee, Aerin Yoon, Junho Chung, Sukmook Lee
Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, the relevance and role of vascular cell adhesion molecule-1 (VCAM-1) in angiogenesis have not yet been clearly elucidated. In this study, VCAM-1 knockdown shows VCAM-1 involvement in TNFα-induced angiogenesis. Through competitive blocking experiments with VCAM-1 Ig-like domain 6 (VCAM-1-D6) protein, we identified VCAM-1-D6 as a key domain regulating TNFα-induced vascular tube formation...
February 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28209916/diabetic-concentrations-of-metformin-inhibit-platelet-mediated-ovarian-cancer-cell-progression
#14
Rafaela Erices, Sofía Cubillos, Raúl Aravena, Felice Santoro, Monica Marquez, Renan Orellana, Carolina Ramírez, Pamela González, Patricia Fuenzalida, María Loreto Bravo, Bárbara Oliva, Sumie Kato, Carolina Ibañez, Jorge Brañes, Erasmo Bravo, Catalina Alonso, Karen García, Clemente Arab, Vicente A Torres, Alejandro S Godoy, Jaime Pereira, Galdo Bustos, Julio Cesar Cardenas, Mauricio A Cuello, Gareth I Owen
Clinical studies have suggested a survival benefit in ovarian cancer patients with type 2 diabetes mellitus taking metformin, however the mechanism by which diabetic concentrations of metformin could deliver this effect is still poorly understood. Platelets not only represent an important reservoir of growth factors and angiogenic regulators, they are also known to participate in the tumor microenvironment implicated in tumor growth and dissemination. Herein, we investigated if diabetic concentrations of metformin could impinge upon the previously reported observation that platelet induces an increase in the tube forming capacity of endothelial cells (angiogenesis) and upon ovarian cancer cell aggressiveness...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28209562/vinexin-%C3%AE-ablation-inhibits-atherosclerosis-in-apolipoprotein-e-deficient-mice-by-inactivating-the-akt-nuclear-factor-%C3%AE%C2%BAb-inflammatory-axis
#15
Hongjing Guan, Wen-Lin Cheng, Junhong Guo, Meng-Lin Chao, Yan Zhang, Jun Gong, Xue-Yong Zhu, Zhi-Gang She, Zan Huang, Hongliang Li
BACKGROUND: Vinexin β is a novel adaptor protein that regulates cellular adhesion, cytoskeletal reorganization, signal transduction, and transcription; however, the exact role that vinexin β plays in atherosclerosis remains unknown. METHODS AND RESULTS: Immunoblot analysis showed that vinexin β expression is upregulated in the atherosclerotic lesions of both patients with coronary heart disease and hyperlipemic apolipoprotein E-deficient mice and is primarily localized in macrophages indicated by immunofluorescence staining...
February 16, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28209486/vasodilator-stimulated-phosphoprotein-vasp-depletion-from-breast-cancer-mda-mb-231-cells-inhibits-tumor-spheroid-invasion-through-downregulation-of-migfilin-%C3%AE-catenin-and-urokinase-plasminogen-activator-upa
#16
Vasiliki Gkretsi, Andreas Stylianou, Triantafyllos Stylianopoulos
A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton thus enabling cells to respond to mechanical cues. Vasodilator-stimulated phosphoprotein (VASP) is an actin-polymerization regulator which interacts with cell-ECM adhesion protein Migfilin, and regulates cell migration. We compared VASP expression in MCF-7 and MDA-MB-231 breast cancer (BC) cells and found that more invasive MDA-MB-231 cells overexpress VASP...
February 13, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28209483/a-new-size-based-platform-for-circulating-tumor-cell-detection-in-colorectal-cancer-patients
#17
Bo Young Oh, Jhingook Kim, Woo Yong Lee, Hee Cheol Kim
BACKGROUND: Circulating tumor cells (CTCs) might play a significant role in cancer progression and metastasis. However, the ability to detect CTCs is limited, especially in cells undergoing epithelial-mesenchymal transition. In this study, we evaluated a new size-based CTC detection platform and its clinical efficacy in colorectal cancer. PATIENTS AND METHODS: Blood samples were obtained from 76 patients with colorectal cancer and 20 healthy control subjects for CTC analysis...
January 25, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28208984/aquaporin-3-and-e-cadherin-expression-in-perilesional-vitiligo-skin
#18
Ola Ahmed Bakry, Magda Mostafa Hagag, Mona Abd El Halim Kandil, Wafaa Ahmed Shehata
INTRODUCTION: Vitiligo is a common dermatologic disorder with debated aetiology. Most studies focused on role of melanocytes and few investigated the role of keratinocytes in pathogenesis of the disease. AIM: To investigate the keratinocyte adhesion in perilesional vitiligo skin through the immunolocalization of Aquaporin-3 (AQP3) and E-cadherin. SETTING AND DESIGN: Sixty five subjects were selected. These included 40 cases with vitiligo and 25 age and gender-matched healthy subjects as a control group...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208647/soy-leaf-extract-exerts-atheroprotective-effects-via-modulation-of-kr%C3%A3-ppel-like-factor-2-and-adhesion-molecules
#19
Jong-Min Han, Hua Li, Moon-Hee Cho, Seung-Hwa Baek, Chul-Ho Lee, Ho-Yong Park, Tae-Sook Jeong
Soy-leaf extracts exert their cardioprotective effects by inducing endothelium-dependent vasodilation in the arteries, and they favorably modulate the serum lipid profile. In this study, we investigated the atheroprotective effects of an ethanol extract of soy leaf (ESL) in human umbilical vein endothelial cells (HUVECs) and high-cholesterol diet (HCD)-fed low-density lipoprotein receptor deficient (LDLR-/-) mice. ESL induced the expression of Krüppel-like factor 2 (KLF2), an endothelial transcription factor, and endothelial nitric oxide synthase (eNOS), and suppressed the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) through moderate inflammatory signal activation, not only in tumor necrosis factor-α (TNF-α)-stimulated HUVECs but also in 7-ketocholesterol (7-KC)-stimulated HUVECs...
February 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28208634/rna-eluting-surfaces-for-the-modulation-of-gene-expression-as-a-novel-stent-concept
#20
Olivia Koenig, Diane Zengerle, Nadja Perle, Susanne Hossfeld, Bernd Neumann, Andreas Behring, Meltem Avci-Adali, Tobias Walker, Christian Schlensak, Hans Peter Wendel, Andrea Nolte
Presently, a new era of drug-eluting stents is continuing to improve late adverse effects such as thrombosis after coronary stent implantation in atherosclerotic vessels. The application of gene expression-modulating stents releasing specific small interfering RNAs (siRNAs) or messenger RNAs (mRNAs) to the vascular wall might have the potential to improve the regeneration of the vessel wall and to inhibit adverse effects as a new promising therapeutic strategy. Different poly (lactic-co-glycolic acid) (PLGA) resomers for their ability as an siRNA delivery carrier against intercellular adhesion molecule (ICAM)-1 with a depot effect were tested...
February 10, 2017: Pharmaceuticals
keyword
keyword
73573
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"