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Mpa Igm

Tian Zhou, Nanping Wang, Yang Xue, Tingting Ding, Xin Liu, Xiumei Mo, Jiao Sun
In this study, tilapia skin collagen sponge and electrospun nanofibers were developed for wound dressing. The collagen sponge was composed of at least two α-peptides, and its denaturation temperature was 44.99 °C. It did not change the number of spleen-derived lymphocytes in BALB/c mice, the ratio of CD4+/CD8+ lymphocytes, and the level of IgG or IgM in Sprague-Dawley rat. The contact angle, tensile strength, and weight loss temperature of collagen nanofibers were 21.2°, 6.72±0.44 MPa, and 300 °C, respectively...
February 11, 2015: ACS Applied Materials & Interfaces
Sílvia G Sousa, Ivonne Delgadillo, Jorge A Saraiva
Human milk, and particularly human colostrum, is the gold standard for newborn nourishment. Colostrum contains the highest concentration of immune factors, being the most potent immune booster known to science. In this work, we investigated Holder pasteurisation and high-pressure processing (HPP) effects on colostral IgA, IgM, IgG, lysozyme and lactoperoxidase. The amount of Igs was significantly decreased after Holder pasteurisation (20%, 51% and 23% for IgA, IgM and IgG, respectively), but fully preserved after HPP at 200 and 400 MPa...
May 15, 2014: Food Chemistry
Claire Roubaud-Baudron, Christian Pagnoux, Nadine Méaux-Ruault, Anne Grasland, Abdelkader Zoulim, Julien LE Guen, Anne Prud'homme, Boris Bienvenu, Mathilde de Menthon, Sandra Camps, Véronique LE Guern, Achille Aouba, Pascal Cohen, Luc Mouthon, Loïc Guillevin
OBJECTIVE: To evaluate the efficacy compared to the relapse risk and tolerance of systematic rituximab (RTX) infusions as maintenance therapy for patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA), who entered remission taking conventional immunosuppressants or RTX. METHODS: A retrospective study of the main clinical characteristics, outcomes, and RTX tolerance of patients who had received ≥ 2 RTX maintenance infusions in our center, regardless of induction regimen, between 2003 and 2010...
January 2012: Journal of Rheumatology
Y Mino, T Naito, K Shimoyama, N Ogawa, J Kawakami
WHAT IS KNOWN AND OBJECTIVE: Mycophenolate mofetil (MMF) has been reported recently to be effective in the treatment of systemic lupus erythematosus (SLE). The therapeutic range of mycophenolic acid (MPA) in SLE in the remission-maintenance phase remains to be clarified. The aim of this study was to evaluate the therapeutic efficacy of MMF and predose plasma concentrations of MPA and its phenolic glucuronide (MPAG) in patients with SLE in the remission-maintenance phase. METHODS: Thirty-one patients with SLE receiving a fixed dosage regimen of MMF (median and interquartile range, 1500 and 1000-2000mg/day) for at least 1month and who had not experienced any adverse drug reactions for more than 3months were enrolled...
April 2012: Journal of Clinical Pharmacy and Therapeutics
Jian Wang, Ying Sun, Liying Wang, Xiaonan Zhu, Hanqi Zhang, Daqian Song
In this paper, the core/shell Fe3O4/Au nanocomposites modified with 3-mercaptopropionic acid (MPA) were prepared and applied in the surface plasmon resonance (SPR) biosensor. And the detailed investigation of Fe3O4/Au nanocomposites was separately performed by UV-vis spectroscopy and transmission electronic microscopy. As the magnetic property and exceptional optical properties, the Fe3O4/Au nanocomposites were used as the solid support for the goat anti-human IgM, which could be immobilized on the surface of SPR biosensor chip by a magnetic pillar...
December 1, 2010: Colloids and Surfaces. B, Biointerfaces
Tomonori Nakanishi, Tatsuaki Morokata, Kaori Kubo, Hitomi Umeno, Yoshiteru Eikyu, Yoshihiro Kozuki, Nobuo Seki
Inosine 5'-monophosphate dehydrogenase (IMPDH) inhibition is a critical target in solid organ transplantation, and the development of mycophenolate mofetil (MMF) represents a major advance in transplant medicine. In this study, the in vitro and in vivo pharmacological effects of BMS-566419, a novel chemically synthesized IMPDH inhibitor, were compared to those of mycophenolic acid (MPA) and MMF based on results from several immunological experiments. The in vitro inhibitory activity of BMS-566419 on IMPDH type I/II, immune cell proliferation and antibody production from lipopolysaccharide (LPS)-stimulated B cells was similar, albeit slightly less potent than that of MPA...
January 2010: International Immunopharmacology
Sebastiaan Heidt, Dave L Roelen, Chantal Eijsink, Cees van Kooten, Frans H J Claas, Arend Mulder
BACKGROUND: Humoral immunity is increasingly recognized as an important factor in the rejection of organ transplants. In general, humoral rejection is treated with standard immunosuppressive drugs. The direct effect of these immunosuppressive drugs on B cells is not well known. METHODS: Purified human B cells devoid of T cells were stimulated with CD40L expressing L cells, or by anti-CD40 mAb with or without Toll-like receptor triggering, all in the presence of B-cell activating cytokines...
November 15, 2008: Transplantation
Tamihiro Kawakami, Masahide Yamazaki, Masako Mizoguchi, Yoshinao Soma
OBJECTIVE: To investigate a possible role of antiphospholipid (aPL) antibodies in adult Henoch-Schönlein purpura (HSP) and cutaneous leukocytoclastic angiitis (CLA). METHODS: We reviewed the records of 30 HSP and 8 CLA adults with an initial cutaneous manifestation of palpable purpura on their lower extremities between 2003 and 2007. Eight microscopic polyangiitis (MPA) patients and 30 healthy persons were recruited as controls. Serum anticardiolipin (aCL), anti-phosphatidylserine-prothrombin complex (anti-PS/PT), and anti-beta(2)-glycoprotein I (anti-beta(2)GPI) antibody levels in HSP, CLA, MPA patients, and healthy controls were measured by enzyme-linked immunosorbent assay...
April 15, 2008: Arthritis and Rheumatism
Yi Liu, Liqun LV
Serum C3, C4, IgG and IgM levels were evaluated in healthy post-menopausal women receiving short-term hormone replacement therapy (HRT) regimens and in untreated women. Serum C3, C4, IgM and IgG levels were assessed in 54 women receiving HRT therapy (CEE 0.625 mg+MPA 2.5 mg/day), and in 54 control women not receiving HRT. The results showed that the mean serum C3 and C4 levels were significantly higher in women receiving HRT than those untreated women (P<0.01). There was significant difference in IgG and IgM levels between two groups...
February 2008: Journal of Huazhong University of Science and Technology. Medical Sciences
Tamihiro Kawakami, Masahide Yamazaki, Masako Mizoguchi, Yoshinao Soma
OBJECTIVE: To investigate possible correlations between cutaneous polyarteritis nodosa (CPN) and antiphospholipid syndrome-associated antibodies. METHODS: Sixteen patients were referred with CPN features. To investigate the possible role of antiphospholipid antibodies (aPL) in CPN, we measured serum lupus anticoagulant (LAC), IgG and IgM anticardiolipin (aCL) and anti-phosphatidylserine-prothrombin complex (anti-PS/PT) antibodies, and anti-beta(2)-glycoprotein I-dependent cardiolipin (anti-beta(2)GPI/CL) antibodies in the 16 CPN patients, 8 microscopic polyangiitis (MPA) patients, 33 systemic lupus erythematosus (SLE) patients, and 23 healthy controls...
December 15, 2007: Arthritis and Rheumatism
B Baum, A Mohr, M Pfaffl, J Bauer, M Hewicker-Trautwein
Mycophenolic acid (MPA) is applied in immunosuppressive therapy after organ transplantation. As a common contaminant in silage, this substance is also frequently fed to sheep unintentionally. In this study, the effect of MPA on the immune system of sheep was examined. Four groups of 9 sheep each were fed 0, 0.5, 1.2, or 5 mg of MPA per kg body weight per day for 6 weeks. Then, the animals were slaughtered and various organs were examined macroscopically, histologically, and immunohistochemically. No effect of MPA on general health was detected...
September 2005: Mycopathologia
Wang-gang Zhang, Lei Ji, Xing-mei Cao, Yin-xia Chen, Ai-li He, Jie Liu, Wan-hong Zhao, San-peng Zou
AIM: To determine whether mycophenolate mofetil (MMF) has beneficial effects on refractory idiopathic thrombocytopenic purpura (ITP) and the corresponding cellular mechanism. METHODS: Twenty refractory ITP patients resistant to corticosteroid and/or splenectomy and chemical therapy were given MMF 1.5-2.0 g/d orally for a 2 to 4-month period. Serum immunoglobulin was detected by rate nephelometry. Platelet-associated antibodies (PAIgG) were assayed by enzyme-linked immunosorbant assay...
May 2005: Acta Pharmacologica Sinica
Youri Chanseaud, Mathieu C Tamby, Philippe Guilpain, Joseph Reinbolt, Marianne Kambouchner, Nathalie Boyer, Laure-Hélène Noël, Loïc Guillevin, Marie-Christophe Boissier, Luc Mouthon
In order to identify new antibody reactivities, we have used a quantitative immunoblotting technique on extracts of normal human tissues to analyze the repertoires of serum IgM, serum IgG and purified IgG autoantibodies of patients with systemic vasculitides. Patients fulfilled the American College of Rheumatology and Chapel Hill criteria for the diagnosis of polyarteritis nodosa (PAN) (n=8), PAN related to hepatitis B virus (HBV) infection (n=5), Wegener's granulomatosis (WG) (n=6), microscopic polyangiitis (MPA) (n=18) or Churg-Strauss syndrome (CSS) (n=8)...
March 2005: Journal of Autoimmunity
Anamarija Dzidic, Anna Mohr, Karsten Meyer, Johann Bauer, Heinrich H D Meyer, Michael W Pfaffl
AIM: To quantify the expression of Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) mRNA under a long-term influence of mycotoxin mycophenolic acid (MPA), which is used in human transplantation medicine due to its immunosuppressive properties and is a common contaminant in silage. METHOD: We applied 300 mg MPA/day in nine sheep for nine weeks and compared them with untreated animals (n=9). The expression level of Ig receptor mRNA was determined in eight different adult ovine tissues (liver, kidney, jejunum, ileum, spleen, thymus, mesenteric and pharyngeal lymph nodes)...
April 2004: Croatian Medical Journal
V D Pradhan, S S Badakere, A R Pawar, A F Almeida
BACKGROUND & OBJECTIVES: Anti-neutrophil cytoplasmic antibodies in active necrotizing and crescentic glomerulonephritis are associated with systemic vasculitides like Wegener's granulomatosis, Microscopic polyangitiis and Churg Strauss Syndrome. This study shows the incidence of ANCA with specificities to Myeloperoxidase and Proteinase3 in MPA cases and gives the correlation of ANCA with Birmingham Vasculitis Activity Score. MATERIAL & METHODS: Eighteen cases of MPA were diagnosed as per Chapel Hill Consensus Criteria...
November 2003: Indian Journal of Medical Sciences
Youri Chanseaud, Paloma García de la Peña-Lefebvre, Philippe Guilpain, Alfred Mahr, Mathieu C Tamby, Michèle Uzan, Loïc Guillevin, Marie Christophe Boissier, Luc Mouthon
Using a quantitative immunoblotting technique on extracts of macrovascular and microvascular endothelial cells (EC), we analyzed serum IgM and IgG reactivities of patients with active disease fulfilling the ACR and Chapel Hill criteria for the diagnosis of polyarteritis nodosa (PAN) (n = 8), PAN related to hepatitis B virus (HBV) infection (HBV-PAN) (n = 5), Wegener's granulomatosis (n = 6), microscopic polyangiitis (MPA) (n = 18), Churg-Strauss syndrome (n = 8), and patients with chronic HBV infection without PAN (n = 5) and age- and gender-matched healthy individuals (n = 45)...
November 2003: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Mehmet Yilmazer, Veysel Fenkci, Semin Fenkci, Orhan Aktepe, Murat Sonmezer, Gulay Kurtay
BACKGROUND: Recently published data suggest that hormone replacement therapy (HRT) may increase cardiovascular risk during the early months of therapy. Activation of the immune system is known to be involved in several types of cardiovascular disease. In this cross-sectional study, serum C3, C4, IgG and IgM levels were evaluated in healthy post-menopausal women receiving two different short-term HRT regimens, and in untreated women. METHODS: Serum C3, C4, IgM and IgG levels were assessed in 18 women receiving transdermal 17beta-estradiol (50 micro g/day) + continuous oral medroxyprogesterone acetate (MPA; 2...
July 2003: Human Reproduction
W S Abdel-sayed, H K Toppozada, S A Said, O K El-sayed
Some metabolic and hormonal changes in women using longacting injectables as a contraceptive method were examined. The 2 main injectables utilized were depomedroxyprogesterone acetate (DMPA), given every 90 +or- 5 days, and norethisterone enanthate (NET/EN) injected every 60 +or- 5 days. None of the studied cases became pregnant during injectable use, indicating the high contraceptive efficacy of the method. No statistically significant changes were observed in hemoglobin, hematocrit, all protein fractions including albumin, alpha1, alpha2 beta, gamma immunoglobulins IgG, IgA, and IgM after 6 and 12 months in both groups of injectable users as compared with the preinjection values...
March 1989: Alexandria Journal of Pharmaceutical Sciences
E Peen, C Malone, C Myers, R C Williams, A B Peck, E Csernok, W L Gross, R Staud
Amphipathic variable-region heavy chain 11-mer peptides from monoclonal human IgM antiproteinase-3 antibodies were studied for peripheral blood lymphocyte stimulation in 21 patients with Wegener's granulomatosis (WG) or microscopic polyangiitis (MPA), connective tissue disease controls and normal control subjects. Positive T-cell activation was observed in most experiments with WG patients' lymphocytes using amphipathic VH-region peptides from four different human monoclonal anti-PR3 antibodies. Control peptides of the same length but without amphipathic characteristics along with other amphipathic peptides not derived from monoclonal anti-PR3 sequence were employed as controls...
August 2001: Clinical and Experimental Immunology
C A Jonsson, H Carlsten
The aim of this study was to evaluate the effects of the immunomodulating drug mycophenolic acid (MPA) on splenocytes in an animal model of systemic lupus erythematosus (SLE), using MRLlpr/lpr mice. MPA reversibly inhibits inosine 5'-monophosphate dehydrogenase, an enzyme involved in the de novo guanosine synthesis. Splenocytes were treated with MPA (at 1 or 10 microM), and stimulated with either lipopolysaccharide (LPS; 10 microg/ml) or concanavalin A (ConA; 1.25 microg/ml). In blocking experiments, guanosine (100 microM) was added to the cultures to inhibit the effects of MPA...
June 2001: Clinical and Experimental Immunology
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