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https://www.readbyqxmd.com/read/29470468/an-audit-of-risk-assessments-for-suicide-and-attempted-suicide-in-ed-a-retrospective-review-of-quality
#1
Wayne de Beer, Bernard DeWitt, Jules Schofield, Helen Clark, Veronique Gibbons
AIM: The primary aim of this audit was to determine the quality of psychiatric risk assessments conducted by Mental Health & Addiction Services clinicians for patients presenting to the emergency department, Waikato Hospital, Hamilton, New Zealand following an attempted suicide. METHOD: A retrospective, randomised audit of 376 files of patients who had presented to the ED over a 12-month period from 1 July 2015 to 30 June 2016 was conducted, following the standards outlined in the present New Zealand Ministry of Health Clinical Practice Guideline for Deliberate Self Harm (DSH)...
February 23, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29470183/the-central-effects-of-androgenic-anabolic-steroid-use
#2
Marek Mędraś, Anna Brona, Paweł Jóźków
: Millions of men use androgenic-anabolic steroids (AAS) to stimulate muscle growth and improve physical appearance. Although 1 out of 3 people who uses androgenic-anabolic steroids develops a steroid use disorder, the effects of the drugs on the central nervous system and the psyche are still not well understood. Although most addictive substances improve mood immediately after administration, AAS exert less pronounced euphoric effects. Instead, they are primarily taken for the delayed gratification of increased muscle mass...
February 21, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29470146/towards-an-effective-peripheral-visceral-analgesic-responding-to-the-national-opioid-crisis
#3
Michael Camilleri
This is an editorial summarizing recent new developments in visceral analgesics. This promising field is important as a new approach to address abdominal pain with peripheral visceral analgesics is considered a key approach to addressing the current opioid crisis. Some of the novel compounds address peripheral pain mechanisms through modulation of opioid receptors through biased ligands, nociceptin/orphanin FQ opioid peptide (NOP) receptor or dual action on NOP and μ-opioid receptor, buprenorphine and morphiceptin analogs...
February 22, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29469633/outpatient-addiction-treatment-for-problematic-alcohol-use-what-makes-patients-who-dropped-out-different-from-those-who-did-not
#4
Vincent Wagner, Didier Acier, Jean-Eric Dietlin
BACKGROUND: A minority of individuals with problematic alcohol use effectively seek help. Moreover, dropouts from care are not uncommon. It remains a major concern for health professionals, as adherence to treatment is significantly associated with better physical and psychological outcomes. OBJECTIVES: The main aim of this research was to assess what factors could distinguish patients with problematic alcohol use who dropped out from those who did not. METHODS: The sample included 150 patients followed-up in an outpatient treatment center in France for a problematic alcohol use...
February 22, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29468884/borrowing-benefits-group-treatment-with-clinical-emotional-freedom-techniques-is-associated-with-simultaneous-reductions-in-posttraumatic-stress-disorder-anxiety-and-depression-symptoms
#5
Dawson Church, Dennis House
Clinical Emotional Freedom Techniques (EFT) is an evidence-based treatment for depression and anxiety. The current study sought to elucidate the relationship between posttraumatic stress disorder (PTSD), depression, and anxiety in a nonclinical population. The sample (N = 81) comprised participants at five 2-day EFT workshops. All groups used an EFT protocol called Borrowing Benefits, in which the group facilitator works with a single client while other participants self-apply EFT. Participants were assessed on 9 specific conditions as well as on the breadth (Positive Symptom Total [PST]) and depth (General Symptom Index [GSI]) of psychological distress...
January 2018: J Evid Based Integr Med
https://www.readbyqxmd.com/read/29465470/opioid-addiction-diversion-and-abuse-in-chronic-and-cancer-pain
#6
Vijay Kata, Matthew B Novitch, Mark R Jones, Best O Anyama, Erik M Helander, Alan D Kaye
PURPOSE OF REVIEW: The primary cause of overdose death in the United States is related to pharmaceutical opioids. A few particular populations that struggle with adverse outcomes related to opioid abuse are those in palliative care, those with chronic pain, and those receiving pain treatments secondary to cancer or chemotherapy. RECENT FINDINGS: There have been massive efforts to decrease the use of opioid abuse in patient care in a gestalt manner, but palliative care provides unique challenges in applying these reduction tactics used by other specialties...
February 19, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29465008/genetic-variations-in-genes-of-the-stress-response-pathway-are-associated-with-prolonged-abstinence-from-heroin
#7
Orna Levran, Einat Peles, Matthew Randesi, Joel Correa da Rosa, Pei-Hong Shen, John Rotrosen, Miriam Adelson, Mary Jeanne Kreek
AIM: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. METHODS: Frequencies of 117 polymorphisms in 30 genes were compared between subjects with history of heroin addiction, either without agonist treatment (n = 129) or in methadone maintenance treatment (n = 923). RESULTS: SNP rs1500 downstream of CRHBP and an interaction of SNPs rs10482672 (NR3C1) and rs4234955 (NPY1R/NPY5R) were significantly associated with prolonged abstinence without agonist treatment...
February 21, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29464058/type-iib-dna-topoisomerase-is-downregulated-by-trastuzumab-and-doxorubicin-to-synergize-cardiotoxicity
#8
Jiangsong Jiang, Nishant Mohan, Yukinori Endo, Yi Shen, Wen Jin Wu
Despite heightened risk of cardiotoxicity associated with combination therapy of anthracyclines and trastuzumab in HER2-positive breast cancer patients, little research effort has been invested in exploring the molecular mechanisms of cardiotoxicity induced by this combination therapy. In this study, we demonstrate that trastuzumab downregulates both gene and protein expressions of type IIB DNA topoisomerase/DNA topoisomerase IIB (TOP2B), a major intracellular target mediating doxorubicin-induced cardiotoxicity, in human primary cardiomyocytes...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29463098/both-active-and-sham-low-frequency-rtms-single-sessions-over-the-right-dlpfc-decrease-cue-induced-cravings-among-pathological-gamblers-seeking-treatment-a-randomized-double-blind-sham-controlled-crossover-trial
#9
Anne Sauvaget, Samuel Bulteau, Alice Guilleux, Juliette Leboucher, Anne Pichot, Pierre Valrivière, Jean-Marie Vanelle, Véronique Sébille-Rivain, Marie Grall-Bronnec
Background Craving is a core symptom of addictive disorders, such as pathological gambling for example. Over the last decade, several studies have assessed the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the addiction field, which triggers the dorsolateral prefrontal cortex (DLPFC) to decrease craving. The STIMJEU study investigated whether a single session of low-frequency (LF, i.e., 1 Hz) rTMS applied to the right DLPFC reduced cue-induced gambling craving in a sample of treatment-seeking pathological gamblers...
February 21, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29462112/microinjection-of-the-mglur2-3-agonist-ly379268-into-the-nucleus-accumbens-attenuates-extinction-latencies-and-the-reinstatement-of-morphine-induced-conditioned-place-preference-in-rats
#10
Negar Baharlouei, Abdolrahman Sarihi, Marzieh Moradi, Shahram Zarrabian, Abbas Haghparast
Previous studies indicate that metabotropic glutamate receptor type 2/3 (mGluR2/3) has a key role in the rewarding properties of morphine-induced conditioning place preference (CPP). Group II mGluR2/3 agonists are offered as a drug addiction treatment. The nucleus accumbens (NAc), which is one of the important areas involved in the reward circuitry, also expresses these receptors. In this study, we evaluated the effects of mGluR2/3 agonist, LY379268, on the extinction and reinstatement of morphine-induced CPP, following its microinjection into the NAc...
February 16, 2018: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29461932/clinical-outcomes-from-a-10-week-follow-up-psychoeducational-programme-for-dual-diagnosis
#11
J Chilton, D Crone, P J Tyson
BACKGROUND: Dual diagnosis covers a broad spectrum of mental health and substance misuse conditions occurring concurrently (NICE, 2016). Its manifestation is complex and as such, the disorder is recognized as influencing adherence to prescribed medication, service engagement and has a worse prognosis than substance use and mental health conditions occurring independently. AIMS: To determine the effectiveness of psycho-educational group therapy on a sample of dual diagnosis patients...
February 20, 2018: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/29461308/interprofessional-communities-of-practice-in-continuing-medical-education-for-promoting-and-sustaining-practice-change-a-prospective-cohort-study
#12
Megan Barker, Julia Lecce, Anna Ivanova, Laurie Zawertailo, Rosa Dragonetti, Peter Selby
INTRODUCTION: Standard knowledge delivery formats for CME may have limited impact on long-term practice change. A community of practice (CoP) is one tool that may enhance competencies and support practice change. This study explores the utility of an interprofessional CoP as an adjunct to a CME program in tobacco addiction treatment (Training Enhancement in Applied Counselling and Health [TEACH] Project) to promote and sustain practice change. METHODS: A prospective cohort design was utilized to examine the long-term impact of the TEACH CoP on practice change...
February 14, 2018: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29460163/noradrenergic-targets-for-the-treatment-of-alcohol-use-disorder
#13
REVIEW
Carolina L Haass-Koffler, Robert M Swift, Lorenzo Leggio
The role of norepinephrine (NE) in the development of alcohol use disorder (AUD) has been studied over the past several decades. However, the NE system has been largely ignored for many years as a potential target for medication development for AUD. More recently, preclinical and clinical studies have demonstrated the potential value of targeting NE signaling for developing new pharmacological treatments for AUD. This review contributes to a special issue of Psychopharmacology focused on promising targets for alcohol addiction...
February 20, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29459328/risk-of-fentanyl-involved-overdose-among-those-with-past-year-incarceration-findings-from-a-recent-outbreak-in-2014-and-2015
#14
Lauren Brinkley-Rubinstein, Alexandria Macmadu, Brandon D L Marshall, Andrew Heise, Shabbar I Ranapurwala, Josiah D Rich, Traci C Green
Overdose is the leading cause of unintentional injury-related death. Rhode Island (RI) has the highest rate of illicit drug use nationally and the 5th highest overdose mortality rate. RI has experienced an outbreak of fentanyl-related overdoses. In incarcerated populations, risk of overdose is greatly elevated. However, little is known about fentanyl-related overdose post-release. In the current analyses, we identify changes in fentanyl-related fatal overdose among those who died in 2014 and 2015 who were incarcerated in the year before death...
February 9, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29457674/a-review-of-brain-stimulation-methods-to-treat-substance-use-disorders
#15
REVIEW
Alexandria S Coles, Karolina Kozak, Tony P George
BACKGROUND: Substance use disorders (SUDs) are a leading cause of disability worldwide. While several pharmacological and behavioral treatments for SUDs are available, these may not be effective for all patients. Recent studies using non-invasive neuromodulation techniques including Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct Current Stimulation (tDCS), and Deep Brain Stimulation (DBS) have shown promise for SUD treatment. OBJECTIVE: Multiple studies were evaluated investigating the therapeutic potential of non-invasive brain stimulation techniques in treatment of SUDs...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457672/gambling-related-cognitive-distortions-predict-level-of-function-among-us-veterans-seeking-treatment-for-gambling-disorders
#16
Steven D Shirk, Megan M Kelly, Shane W Kraus, Marc N Potenza, Kendra Pugh, Christopher Waltrous, Edward Federman, Christopher Krebs, Charles E Drebing
BACKGROUND AND OBJECTIVES: Gambling Disorder (GD) is characterized by recurrent gambling behavior that is associated with significant impairment and distress, high psychiatric comorbidities, and high functional disability. The military veteran population appears particularly susceptible to developing the disorder, but relatively little has been studied among this population. The purpose of the present study is to investigate the clinical psychopathologies and comorbidities of veterans seeking treatment for problem gambling and how problem gambling may impact functioning...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457671/abstinence-and-reduced-frequency-of-use-are-associated-with-improvements-in-quality-of-life-among-treatment-seekers-with-cannabis-use-disorder
#17
Christina A Brezing, C Jean Choi, Martina Pavlicova, Daniel Brooks, Amy L Mahony, John J Mariani, Frances R Levin
BACKGROUND AND OBJECTIVE: Many patients with cannabis use disorder (CUD) do not achieve or do not have abstinence as a goal of treatment, rather they reduce their use. Assessing outcome measures as they relate to functioning and reductions in cannabis use is an important area of study. Quality of life (QoL) shows promise as one such measure. Past studies have demonstrated gender differences in QoL and CUD. We aim to assess (1) the relationship between cannabis use and QoL and (2) gender effects in an outpatient medication treatment study for CUD...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29457668/the-relationships-between-depression-neuroticism-and-attitudes-nda-model-in-heroin-abusers-in-taiwan
#18
Kun-Hua Lee, Cheng-Fang Yen
BACKGROUND AND OBJECTIVES: Heroin use is a severe problem worldwide. To develop more effective treatments for heroin abusers, a comprehensive psychosocial model of heroin use should be established and examined. We created and assessed a neuroticism, depression, attitudes, and heroin addiction (NDA) model. METHODS: In this cross-sectional study, 234 patients undergoing methadone replacement treatment were recruited from psychiatric clinics. We used Structural Equation Modeling (SEM) to assess all for neuroticism, depression, and a positive outcome expectancy (POE) (attitudes)...
February 19, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29455053/the-becoming-of-methadone-in-kenya-how-an-intervention-s-implementation-constitutes-recovery-potential
#19
Tim Rhodes
This analysis treats the recent introduction of methadone treatment in Kenya as a case of 'evidence-making intervention'. Using 30 qualitative interviews with people in receipt of methadone treatment in Nairobi, Kenya, methadone's becoming is treated as an effect of its narrative and material implementations. The interviews are shown to enact a narrative of methadone recovery potential towards normalcy beyond addiction. Such recovery potential is materialised in practice through social interactions wherein methadone's embodied effects are seen to be believed...
February 10, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29454155/immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-nsclc-approaches-on-special-subgroups-and-unresolved-burning-questions
#20
REVIEW
J Remon, N Vilariño, N Reguart
Immune checkpoint inhibitors (ICIs) have been incorporated in the treatment strategy of advanced non-small cell lung cancer (NSCLC). Beyond the already approved indications in first- and second-line setting of advanced NSCLC, new data has recently emerged demonstrating its efficacy in locally advanced disease as maintenance after chemo-radiotherapy and currently several trials are also exploring its efficacy in earlier stages of the disease to evaluate whether these results could be extrapolated to the adjuvant setting...
February 8, 2018: Cancer Treatment Reviews
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