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https://www.readbyqxmd.com/read/29045593/a-teleost-androgen-promotes-development-of-primary-ovarian-follicles-in-coho-salmon-and-rapidly-alters-the-ovarian-transcriptome
#1
Christopher Monson, Kristy Forsgren, Giles Goetz, Louisa Harding, Penny Swanson, Graham Young
Recent studies using several teleost models have revealed that androgens increase the size of previtellogenic (primary and/or early secondary) ovarian follicles. To explore our hypothesis that androgens drive the development of primary follicles into early secondary follicles, and to determine the mechanisms underlying these androgenic effects, we exposed juvenile coho salmon to near-physiological and relatively sustained levels of the non-aromatizable androgen 11-ketotestosterone (11-KT). This resulted in significant growth of primary ovarian follicles after 10 and 20 days, with follicles after 20 days displaying a morphological phenotype characteristic of early secondary follicles (presence of cortical alveoli)...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29045572/impaired-sperm-maturation-in-conditional-lcn6-knockout-mice
#2
Qianqian Yin, Jia Shen, Xiaofeng Wan, Qiang Liu, Yuchuan Zhou, Yonglian Zhang
Human LCN6, a lipocalin protein, exhibits predominant expression in epididymis and location on the sperm surface. However, the biological function of LCN6 in vivo remains unknown. Herein, we found that unlike human LCN6, mouse Lcn6 gene encoded two transcript variants that were both up regulated by androgen. Subsequently, we generated a conditional knockout mouse model to disrupt Lcn6 in the adult and investigate its function. In this model, spermatogenesis was normal and Lcn6 deficiency did not affect the natural birth rate of male mice or in vitro fertilization ability of their cauda epididymal sperm...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29045551/validation-of-a-metastatic-assay-using-biopsies-to-improve-risk-stratification-in-patients-with-prostate-cancer-treated-with-radical-radiation-therapy
#3
S Jain, C A Lyons, S M Walker, S McQuaid, S Hynes, D Mitchell, B Pang, G E Logan, A M McCavigan, D O'Rourke, D McArt, S McDade, I Mills, K M Prise, L A Knight, C J Steele, P W Medlow, V Berge, B Katz, D A Loblaw, D P Harkin, J James, J M O'Sullivan, R D Kennedy, D J Waugh
BackgroundRadiotherapy is an effective treatment for intermediate/high-risk locally-advanced prostate cancer, however, >30% of patients relapse within five years. Clinicopathological parameters currently fail to identify patients prone to systemic relapse and those whom treatment intensification may be beneficial. The purpose of this study was to independently validate the performance of a 70-gene Metastatic Assay in a cohort of diagnostic biopsies from patients treated with radical radiotherapy and androgen deprivation therapy (ADT)...
October 10, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044734/association-of-androgen-receptor-gene-cag-and-ggn-repeat-polymorphism-with-cryptorchidism-a-meta-analysis
#4
Qi Wang, Xing Ge, Heng-Xue Wang, Qiao-Mei Shi, Zhen Ding, Li-Chun Xu
Researches on association between variations in the androgen receptor (AR) gene repeat polymorphisms and cryptorchidism (CO) had conflicting results. The aim of this meta-analysis was to analyse the potential effects of AR CAG and/or GGN repeat polymorphism on CO. Studies were independently appraised by two investigators on PubMed, Web of Science, EBSCO databases and Foreign Medical Retrieval System. Case-control studies with measurement of CAG and/or GGN repeat length were included. Weighted mean difference (WMD) and 95% confidence intervals (CIs) for the CAG or GGN repeat polymorphism and CO were calculated...
October 18, 2017: Andrologia
https://www.readbyqxmd.com/read/29044613/effect-of-androgen-deprivation-therapy-on-the-contractile-properties-of-type-i-and-type-ii-skeletal-muscle-fibres-in-men-with-non-metastatic-prostate-cancer
#5
C R Lamboley, H Xu, T L Dutka, E D Hanson, A Hayes, J A Violet, R M Murphy, G D Lamb
The contractile properties of vastus lateralis muscle fibres were examined in prostate cancer (PrCa) patients undergoing androgen deprivation therapy (ADT) and in age- and activity-matched healthy male subjects (Control). Mechanically-skinned muscle fibres were exposed to a sequence of heavily Ca(2+) -buffered solutions at progressively higher free [Ca(2+) ] to determine their force-Ca(2+) relationship. Ca(2+) -sensitivity was decreased in both type I and type II muscle fibres of ADT subjects relative to Controls (by -0...
October 17, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29044447/relationship-between-androgen-deficiency-and-memory-impairment-in-aging-and-alzheimer-8217-s-disease
#6
Graciela Jiménez-Rubio, José J Herrera-Pérez, Olivia T Hernández-Hernández, Lucía Martínez-Mota
Aging and Alzheimer’s disease (AD) are associated with a declination of cognition and memory, whose severity increases in AD. Recent investigations point to a greater participation of neurofibrillary tangles (NFTs) than that of senile plaques, as responsible for cognitive impairment in AD and normal aging. On the other hand, aging is related with reduced levels of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) as well as testosterone (T). Basic and clinical studies give evidence that hypoandrogenism is associated with memory impairment...
September 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29044297/psa-levels-psa-doubling-time-gleason-score-and-prior-therapy-cannot-predict-measured-uptake-of-68-ga-psma-hbed-cc-lesion-uptake-in-recurrent-metastatic-prostate-cancer
#7
Frederik A Verburg, David Pfister, Natascha I Drude, Felix M Mottaghy, Florian Behrendt
AIM: To assess whether clinical prostate cancer (PCA) related factors and therapy status can predict the degree of tracer uptake on [(68)Ga]PSMA-HBED-CC PET/CT. MATERIALS & METHODS: We retrospectively studied 124 patients with recurrent an/or metastatic PCA who underwent [(68)Ga]PSMA-HBED-CC PET/CT. The maximum standardized uptake value (SUVmax) was determined in the prostate bed as well as in three size categories (≤ 5 mm, > 5-15 mm, > 15 mm) in pelvic lymph node, extrapelvic lymph node, bone and visceral metastases...
October 18, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/29042395/nuclear-receptor-profiling-in-prostatospheroids-and-castration-resistant-prostate-cancer
#8
Zhu Wang, Dinglan Wu, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Shan Yu, Yuliang Wang, Franky Leung Chan
Nuclear receptors (NRs), which belong to a superfamily of transcription factors and consist of a total of 48 members in humans, govern the expression of genes involved in a board range of developmental, reproductive, metabolic and immunological programs. Given the significant importance of androgen receptor and a few known NRs in the progression of prostate cancer, we surveyed the expression profiles of the entire NR superfamily in three-dimensional (3D) cultured prostatospheroids derived from different prostate cancer cell lines and a tumor xenograft model of castration-resistant prostate cancer VCaP-CRPC by quantitative real-time RT-PCR...
October 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29042125/survival-outcomes-of-men-with-lymph-node-positive-prostate-cancer-after-radical-prostatectomy-a-comparative-analysis-of-different-postoperative-management-strategies
#9
Karim A Touijer, Robert Jeffery Karnes, Niccolo Passoni, Daniel D Sjoberg, Melissa Assel, Nicola Fossati, Giorgio Gandaglia, James A Eastham, Peter T Scardino, Andrew Vickers, Cesare Cozzarini, Francesco Montorsi, Alberto Briganti
BACKGROUND: Optimal management of patients with lymph node metastasis (LNM) after radical prostatectomy (RP) remains undefined. OBJECTIVE: We evaluated the association between three different management strategies and survival in prostate cancer with LNM after RP. DESIGN, SETTING, AND PARTICIPANTS: We analyzed data of 1338 patients with LNM after RP from three tertiary care centers. Three hundred and eighty-seven patients (28%) were observed, 676 (49%) received lifelong adjuvant androgen deprivation therapy (ADT), and 325 (23%) received adjuvant external beam radiation therapy (EBRT) and ADT...
October 14, 2017: European Urology
https://www.readbyqxmd.com/read/29040537/chromosomal-abnormalities-in-1663-infertile-men-with-azoospermia-the-clinical-consequences
#10
R B Donker, V Vloeberghs, H Groen, H Tournaye, C M A van Ravenswaaij-Arts, J A Land
STUDY QUESTION: What is the prevalence of chromosomal abnormalities in azoospermic men and what are the clinical consequences in terms of increased risk for absent spermatogenesis, miscarriages and offspring with congenital malformations? SUMMARY ANSWER: The prevalence of chromosomal abnormalities in azoospermia was 14.4%, and the number of azoospermic men needed to be screened (NNS) to identify one man with a chromosomal abnormality with increased risk for absence of spermatogenesis was 72, to prevent one miscarriage 370-739 and to prevent one child with congenital malformations 4751-23 757...
October 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040227/testosterone-supplementation-and-retinal-vascular-disease
#11
Vaidehi S Dedania, David N Zacks, Wei Pan, Brian L VanderBeek
PURPOSE: To determine whether testosterone supplementation is associated with retinal artery occlusion (RAO) or retinal vein occlusion (RVO). METHODS: Retrospective matched cohort study using data from a large national U.S. insurance database. The testosterone cohort consisted of all male patients who filled a prescription for testosterone from 2000 to 2013. Five controls were matched on age (±3 years), sex, race, and similar time in plan (±3 months) for every exposed patient...
October 13, 2017: Retina
https://www.readbyqxmd.com/read/29040222/neurovascular-response-during-exercise-and-mental-stress-in-anabolic-steroid-users
#12
Rafael Armani Porello, Marcelo Rodrigues Dos Santos, Francis Ribeiro de Souza, Guilherme Wesley Peixoto da Fonseca, Ana Luiza Carrari Sayegh, Tiago Franco de Oliveira, César Abreu Akiho, Maurício Yonamine, Rosa Maria Rodrigues Pereira, Carlos Eduardo Negrão, Maria-Janieire de Nazaré Nunes Alves
PURPOSE: Increased resting muscle sympathetic nerve activity (MSNA) and lower forearm blood flow (FBF) were observed in young men who use anabolic androgenic steroids (AAS). However, the response of MSNA and FBF in AAS users triggered by muscle mechanoreflex and central command has never been tested. Additionally, we evaluated the blood pressure (BP) and heart rate (HR) responses during these maneuvers. METHODS: Nineteen AAS users (AASU) aged 31±6 yr and 18 AAS nonusers (AASNU) aged 29±4 yr were recruited...
October 16, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29039509/evaluation-of-a-novel-dry-eye-model-induced-by-oral-administration-of-finasteride
#13
Kai Li, Chuanwei Zhang, Zichao Yang, Yuliang Wang, Haipeng Si
Dry eye is a common eye disease, and suitable animal models are indispensable for investigating the pathogenesis and developing treatments for dry eye. The present study was conducted to develop an androgen deficiency dry eye model induced by finasteride, and to evaluate ocular surface status and inflammatory cytokine gene expression in the lacrimal gland using a cytokine antibody array system. The results revealed that the antiandrogenic drug finasteride induced significant tear deficiency, and the histopathology results revealed significant inflammatory cell infiltration in the lacrimal gland...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039174/-long-term-effects-of-polycystic-ovary-syndrome-on-the-offspring
#14
Dan Shen, Fangfang Wang, Zhou Jiang, Fan Qu
Polycystic ovary syndrome (PCOS) is an endocrine disorder with reproductive dysfunction and abnormal metabolic syndrome. However, its etiology is unknown yet. Androgen hypersecretion is one of the main features of PCOS. It has been found that PCOS has various effects on the offspring in reproductive, metabolic and nervous systems, including:increasing secretion of gonadotropin-releasing hormone and luteinizing hormone, ovarian morphological changes and abnormal secretion of sex hormones, leading to disorders of lipid and glucose metabolism, and increasing the risks of depression and autism...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29038356/local-production-of-neurostradiol-affects-gonadotropin-releasing-hormone-gnrh-secretion-at-mid-gestation-in-lagostomus-maximus-rodentia-caviomorpha
#15
Santiago E Charif, Pablo I F Inserra, Alejandro R Schmidt, Noelia P Di Giorgio, Santiago A Cortasa, Candela R Gonzalez, Victoria Lux-Lantos, Julia Halperin, Alfredo Daniel Vitullo, Verónica B Dorfman
Females of the South American plains vizcacha, Lagostomus maximus, show peculiar reproductive features such as massive polyovulation up to 800 oocytes per estrous cycle and an ovulatory process around mid-gestation arising from the reactivation of the hypothalamic-hypophyseal-ovary (H.H.O.) axis. Estradiol (E2) regulates gonadotropin-releasing hormone (GnRH) expression. Biosynthesis of estrogens results from the aromatization of androgens by aromatase, which mainly occurs in the gonads, but has also been described in the hypothalamus...
October 2017: Physiological Reports
https://www.readbyqxmd.com/read/29038344/blocking-myristoylation-of-src-inhibits-its-kinase-activity-and-suppresses-prostate-cancer-progression
#16
Sungjin Kim, Omar Awad Alsaidan, Octavia Goodwin, Qianjin Li, Essilvo Sulejmani, Zhen Han, Aiping Bai, Thomas Albers, Zanna Beharry, Y George G Zheng, James S Norris, Zdzislaw M Szulc, Alicja Bielawska, Iryna Lebedyeva, Scott D Pegan, Houjian Cai
Protein N-myristoylation enables localization to membranes and helps maintain protein conformation and function. N-myristoyltransferases (NMT) catalyze co- or post-translational myristoylation of Src family kinases and other oncogenic proteins, thereby regulating their function. In this study, we provide genetic and pharmacological evidence that inhibiting the N-myristoyltransferase NMT1 suppresses cell cycle progression, proliferation and malignant growth of prostate cancer cells. Loss of myristoylation abolished the tumorigenic potential of Src and its synergy with androgen receptor in mediating tumor invasion...
October 16, 2017: Cancer Research
https://www.readbyqxmd.com/read/29038335/preclinical-and-coclinical-studies-in-prostate-cancer
#17
Ming Chen, Pier Paolo Pandolfi
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage prostate cancer (PCa). Insights from the mCRPC genomic landscape have revealed that, in addition to sustained androgen receptor (AR) signaling, there are other actionable molecular alterations and distinct molecular subclasses of PCa; however, the rate at which this knowledge translates into patient care via current preclinical testing is painfully slow and inefficient...
October 16, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29037971/to-fight-or-mate-hormonal-control-of-sex-recognition-male-sexual-behavior-and-aggression-in-the-gecko-lizard
#18
Tereza Schořálková, Lukáš Kratochvíl, Lukáš Kubička
Squamate reptiles are a highly diversified vertebrate group with extensive variability in social behavior and sexual dimorphism. However, hormonal control of these traits has not previously been investigated in sufficient depth in many squamate lineages. Here, we studied the hormonal control of male sexual behavior, aggressiveness, copulatory organ (hemipenis) size and sex recognition in the gecko Paroedura picta, comparing ovariectomized females, ovariectomized females treated with exogenous dihydrotestosterone (DHT), ovariectomized females treated with exogenous testosterone (T), control females and males...
October 13, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29037803/prognostic-significance-and-biopsy-characteristics-of-prostate-cancer-with-seminal-vesicle-invasion-on-radical-prostatectomy-a-nationwide-population-based-study
#19
Anna Kristiansen, Linda Drevin, Brett Delahunt, Hemamali Samaratunga, David Robinson, Ingela Franck Lissbrant, Pär Stattin, Lars Egevad
The objective of this study was to evaluate the prognostic significance of seminal vesicle invasion (SVI, pT3b) compared with extraprostatic extension (EPE) alone (pT3a) after radical prostatectomy, and to correlate pre-operative biopsy pathology with SVI and EPE. The National Prostate Cancer Register includes all prostate cancers diagnosed in Sweden. We analysed 4063 cases with stage category pT3a and 1371 cases with pT3b at radical prostatectomy between 2000 and 2012. Associations between pT3a and pT3b and progression were evaluated and adjusted for year, age, biopsy grade and s-PSA...
October 13, 2017: Pathology
https://www.readbyqxmd.com/read/29037513/comparison-of-abiraterone-acetate-and-docetaxel-with-androgen-deprivation-therapy-in-high-risk-and-metastatic-hormone-na%C3%A3-ve-prostate-cancer-a-systematic-review-and-network-meta-analysis
#20
REVIEW
Christopher J D Wallis, Zachary Klaassen, Bimal Bhindi, Hanan Goldberg, Thenappan Chandrasekar, Ann M Farrell, Stephen A Boorjian, Girish S Kulkarni, Robert Jeffrey Karnes, Raj Satkunasivam
CONTEXT: Randomized clinical trials have recently examined the benefit of adding docetaxel or abiraterone to androgen deprivation therapy (ADT) in hormone-naïve advanced prostate cancer (PCa). OBJECTIVE: To perform a systematic review and network meta-analysis of randomized clinical trials, indirectly evaluating overall survival (OS) for men treated with abiraterone acetate plus prednisone/prednisolone with ADT (Abi-ADT) versus docetaxel with ADT (Doce-ADT) in hormone-naïve high-risk and metastatic PCa...
October 13, 2017: European Urology
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