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https://www.readbyqxmd.com/read/29917261/diagnostic-accuracy-of-immunohistochemical-markers-in-differentiation-between-basal-cell-carcinoma-and-trichoepithelioma-in-small-biopsy-specimens
#1
Naglaa A Mostafa, Magda Assaf, Sami Elhakim, Mona R E Abdel-Halim, Eman El-Nabarawy, Khaled Ghareeb
BACKGROUND: The distinction of trichoepithelioma from basal cell carcinoma in small superficial biopsies is important but often challenging. This has inspired many scientists to test the validity of immunohistochemical markers in the differential diagnosis. OBJECTIVES: to develop an immunohistochemical protocol that helps in differentiation between both TE and BCC with higher sensitivity and specificity. METHODS: Using standard immunohistochemical techniques, we examined 10 TEs and 19 BCCs for the expression of CK19, Ki67, Androgen receptors (AR), CD10, and PHLDA1...
June 19, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29917167/androgen-receptor-induces-epha3-expression-by-interacting-with-transcription-factor-sp1
#2
Xiaowei Diao, Xiubin Chen, Yurui Pi, Yu Zhang, Fangfang Wang, Ping Liu, Yanhong Gao, Xiaojun Wang, Sijun Yang, Shan Lu
Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. However, the regulation of EPHA3 in PCa remains largely unknown. This study is aimed to investigate the association between EPHA3 expression and androgen receptor (AR) signaling and the potential mechanism. We determined mRNA and protein levels of EPHA3 and AR signaling‑related genes in the PCa cell line 22Rv1 by reverse transcription‑polymerase chain reaction (RT‑PCR) and western blotting, respectively...
June 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29917166/sb225002-inhibits-prostate-cancer-invasion-and-attenuates-the-expression-of-bsp-opn-and-mmp%C3%A2-2
#3
Meng Xu, Huamao Jaing, Haiguang Wang, Jiajie Liu, Baohao Liu, Zhongqiang Guo
The mechanisms of malignant cell metastasis to secondary sites are complex and multifactorial. Studies have demonstrated that small integrin‑binding ligand N‑linked glycoproteins (SIBLINGs), particularly bone sialoprotein (BSP) and osteopontin (OPN), are involved in neoplastic growth and metastasis. SIBLINGs promote malignant cell invasion and metastasis by enhancing matrix metalloproteinase 2 (MMP‑2) and MMP‑9 expression. Moreover, BSP and OPN can combine with integrin, which is located on the tumor cell surface, to further promote the malignant behavior of tumor cells...
June 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29917083/sex-differences-in-reproductive-hormones-during-mini-puberty-in-infants-with-normal-and-disordered-sex-development
#4
T H Johannsen, K M Main, M L Ljubicic, T K Jensen, H R Andersen, M S Andersen, J H Petersen, A-M Andersson, A Juul
CONTEXT: The early activation of the hypothalamic-pituitary-gonadal axis during infancy can be used in the evaluation of infants suspected of disorders of sex development (DSD). However, few data exists on sex-specific reference ranges for these hormones during early life. OBJECTIVE: To evaluate sex-differences in reproductive hormone concentrations in serum from healthy infants in order to define sex-specific cut-off values and to apply these in infants with DSD...
June 15, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29916947/factors-associated-with-developing-vaginal-dryness-symptoms-in-women-transitioning-through-menopause-a-longitudinal-study
#5
L Elaine Waetjen, Sybil L Crawford, Po-Yin Chang, Barbara D Reed, Rachel Hess, Nancy E Avis, Sioban D Harlow, Gail A Greendale, Sheila A Dugan, Ellen B Gold
OBJECTIVE: To evaluate factors associated with incident self-reported vaginal dryness and the consequences of this symptom across the menopausal transition in a multiracial/ethnic cohort of community-dwelling women. METHODS: We analyzed questionnaire and biomarker data from baseline and 13 approximately annual visits over 17 years (1996-2013) from 2,435 participants in the Study of Women's Health Across the Nation, a prospective cohort study. We used discrete-time Cox proportional-hazards regression to identify predictors of incident vaginal dryness and to evaluate vaginal dryness as a predictor of pain during intercourse and changes in sexual intercourse frequency...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29916921/assessment-of-treatment-response-by-99mtc-mip-1404-spect-ct-a-pilot-study-in-patients-with-metastatic-prostate-cancer
#6
Christian Schmidkonz, Michael Cordes, Michael Beck, Theresa Ida Goetz, Daniela Schmidt, Olaf Prante, Tobias Bäuerle, Alexander Cavallaro, Michael Uder, Bernd Wullich, Peter Goebell, Torsten Kuwert, Philipp Ritt
BACKGROUND: We investigated the role of Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) SPECT/CT of PSMA expression in the assessment of treatment response in patients with metastatic prostate cancer. METHODS: We retrospectively analyzed Tc-MIP-1404 SPECT/CT scans from 28 patients with metastatic prostate cancer examined before initiation and after completion of therapy. Eight of these patients had been treated with androgen deprivation therapy, 10 with docetaxel, and another 10 with external beam radiotherapy...
June 19, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29916747/tumor-suppressive-function-of-mir-30d-5p-in-prostate-cancer-cell-proliferation-and-migration-by-targeting-nt5e
#7
Yongbo Song, Chao Song, Sixing Yang
MiR-30d-5p, a member of the microRNA family, was recently reported to regulate androgen receptor signaling in prostate cancer (PCa). Ecto-5'-nucleotidase (NT5E/CD73) is a pivotal regulator of tumor migration and has angiogenetic properties. However, the undiscovered function of miR-30d-5p and whether it targeted NT5E in PCa remain uncertain. In this study, the authors observed miR-30d-5p was significantly downregulated in PCa tissues and cell lines compared with the adjacent normal tissues and normal prostate cells, respectively...
June 2018: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29915882/androgen-receptor-and-ki67-expression-and-survival-outcomes-in-non-small-cell-lung-cancer
#8
Laurel Grant, Shantanu Banerji, Leigh Murphy, David E Dawe, Craig Harlos, Yvonne Myal, Zoann Nugent, Anne Blanchard, Carla R Penner, Gefei Qing, Marshall W Pitz
Lung cancer is the most common cause of cancer-related deaths worldwide with non-small cell lung cancer (NSCLC) making up most of these cases. Males have poorer overall survival compared to women following a lung cancer diagnosis. Many studies have focused on the effects of estrogen to explain higher survival rates among women, but few have looked at the effects of androgens. We describe the expression of the androgen receptor (AR) and Ki67 in lung cancer specimens in the Manitoba Tumor Bank (MTB) and correlate these factors with patient outcome...
June 18, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29914823/association-between-androgen-receptor-polymorphic-cag-and-ggc-repeat-lengths-and-cryptorchidism-a-meta-analysis-of-case-control-studies
#9
Y Wang, Y Wei, X Tang, B Liu, L Shen, C Long, T Lin, D He, S Wu, G Wei
INTRODUCTION: Previous studies have revealed the relationship between androgen receptor (AR) CAG and/or GGC polymorphisms and risk of cryptorchidism, yet the results have been elusive and controversial. AIM: To determine whether AR polymorphic CAG and/or GGC repeats are related to cryptorchidism. STUDY DESIGN: The relevant studies were obtained from PubMed, Embase, China National Knowledge Infrastructure, and Wanfang. The pooled odds ratios with 95% confidence intervals (CIs) were used to assess the strength of associations...
June 7, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29914436/treatment-in-the-stampede-era-for-castrate-resistant-prostate-cancer-in-the-uk-ongoing-challenges-and-underappreciated-clinical-problems
#10
Rosa U Greasley, Rebecca Turner, Karen Collins, Janet Brown, Liam Bourke, Derek J Rosario
BACKGROUND: This study aimed to explore the opinions of healthcare professionals regarding the management of men with advanced prostate cancer with particular emphasis on treatment timing and sequencing; treatment adverse-effects and exercise a supportive therapy. METHODS: Semi-structured interviews with a purposively selected group of healthcare professionals involved in prostate cancer care within the NHS, conducted over the phone or face to face. A total of 37 healthcare professionals participated in the interviews including urologists, clinical oncologists, medical oncologists, clinical nurse specialists, general practitioners, physiotherapists, exercise specialists, service managers, clinical commissioners and primary care physicians...
June 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29914187/prostate-associated-gene-4-page4-leveraging-the-conformational-dynamics-of-a-dancing-protein-cloud-as-a-therapeutic-target
#11
REVIEW
Ravi Salgia, Mohit Kumar Jolly, Tanya Dorff, Clayton Lau, Keith Weninger, John Orban, Prakash Kulkarni
Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy. Here, we discuss how PAGE4, a protein which appears to act both as an oncogenic factor as well as a metastasis suppressor, is a novel therapeutic target for PCa. Inhibiting PAGE4 may be a viable strategy for low-risk PCa where it is highly upregulated. Conversely, PAGE4 expression is downregulated in metastatic PCa and, therefore, reinstituting its sustained expression may be a promising option to subvert or attenuate androgen-resistant PCa...
June 17, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29914135/endocrine-disruption-at-the-androgen-receptor-employing-molecular-dynamics-and-docking-for-improved-virtual-screening-and-toxicity-prediction
#12
Joel Wahl, Martin Smieško
The androgen receptor (AR) is a key target for the development of drugs targeting hormone-dependent prostate cancer, but has also an important role in endocrine disruption. Reliable prediction of the binding of ligands towards the AR is therefore of great relevance. Molecular docking is a powerful computational method for exploring small-ligand binding to proteins. It can be applied for virtual screening experiments but also for predicting molecular initiating events in toxicology. However, in case of AR, there is no antagonist-bound crystal structure yet available...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29913543/recommendations-for-the-use-of-testosterone-in-male-transgender
#13
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913432/transcriptome-analysis-reveals-novel-insights-into-the-response-of-low-dose-benzo-a-pyrene-exposure-in-male-tilapia
#14
Reyna Cristina Colli-Dula, Xiefan Fang, David Moraga-Amador, Nacira Albornoz-Abud, Roberto Zamora-Bustillos, Ana Conesa, Omar Zapata-Perez, Diego Moreno, Emanuel Hernandez-Nuñez
Despite a wide number of toxicological studies that describe benzo[a]pyrene (BaP) effects, the metabolic mechanisms that underlie these effects in fish are largely unknown. Of great concern is the presence of BaP in aquatic systems, especially those in close proximity to human activity leading to consumption of potentially contaminated foods. BaP is a known carcinogen and it has been reported to have adverse effects on the survival, development and reproduction of fish. The purpose of this study was to investigate if a low dose of BaP can alter genes and key metabolic pathways in the liver and testis in male adult tilapia, and whether these could be associated with biological endpoints disruption...
June 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29912985/the-association-between-pubertal-status-and-depressive-symptoms-and-diagnoses-in-adolescent-females-a-population-based-cohort-study
#15
Gemma Lewis, Konstantinos Ioannidis, Anne-Laura van Harmelen, Sharon Neufeld, Jan Stochl, Glyn Lewis, Peter B Jones, Ian Goodyer
BACKGROUND: There is an association between puberty and depression, but many things remain poorly understood. When assessing puberty in females, most studies combine indicators of breast and pubic hair development which are controlled by different hormonal pathways. The contributions of pubertal timing (age at onset) and pubertal status (stage of development, irrespective of timing) are also poorly understood. We tested the hypothesis that stage of breast development in female adolescents, controlled largely by increased estradiol, would be more strongly associated with depression than pubic hair development which occurs in both males and females, and is controlled by adrenal androgens...
2018: PloS One
https://www.readbyqxmd.com/read/29912871/ar-negative-triple-negative-or-quadruple-negative-breast-cancers-in-african-american-women-have-an-enriched-basal-and-immune-signature
#16
Melissa Davis, Shweta Tripathi, Raymond Hughley, Qinghua He, Sejong Bae, Balasubramanyam Karanam, Rachel Martini, Lisa Newman, Windy Colomb, William Grizzle, Clayton Yates
There is increasing evidence that Androgen Receptor (AR) expression has prognostic usefulness in Triple negative breast cancer (TNBC), where tumors that lack AR expression are considered "Quadruple negative" Breast Cancers ("QNBC"). However, a comprehensive analysis of AR expression within all breast cancer subtypes or stratified by race has not been reported. We assessed AR mRNA expression in 925 tumors from The Cancer Genome Atlas (TCGA), and 136 tumors in 2 confirmation sets. AR protein expression was determined by immunohistochemistry in 197 tumors from a multi-institutional cohort, for a total of 1258 patients analyzed...
2018: PloS One
https://www.readbyqxmd.com/read/29912017/hypertensive-disorders-of-pregnancy-and-genital-anomalies-in-boys-a-danish-nationwide-cohort-study
#17
Linn Håkonsen Arendt, Tine Brink Henriksen, Morten Søndergaard Lindhard, Erik T Parner, Jørn Olsen, Cecilia Høst Ramlau-Hansen
BACKGROUND: Although congenital abnormalities in the male reproductive tract are common, their causes remain poorly understood. We studied associations between hypertensive disorders of pregnancy (pre-gestational hypertension, gestational hypertension, and preeclampsia) and the genital anomalies, cryptorchidism (undescended testes), and hypospadias (ventrally displaced urethral meatus). METHODS: We established a population of 1,073,026 Danish boys born alive between 1 January 1978 and 31 December 2012...
June 14, 2018: Epidemiology
https://www.readbyqxmd.com/read/29911618/association-between-chronic-pain-and-the-sperm-motion-characteristics
#18
F Dardmeh, H Alipour, H I Nielsen, S Rasmussen, J T Yousefi, N E Ditlevsen, H A A K T Yassin, E Morina, R K Duus, P Gazerani
Aims Sex hormones play an important role in pain in many chronic pain conditions. Relationship between chronic pain and sperm quality has not been investigated thoroughly and may provide an insight to better understanding, management and treatment of cases where chronic pain and male sub-fertility co-exist. Methods Neat (fresh semen) and processed sperm from 15 males with orthopedic chronic pain (CP) were assessed and compared with 15 healthy age matched controls. Sperm analysis was performed using the SCA computer-aided sperm analyzer...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911070/mechanisms-and-approaches-for-overcoming-enzalutamide-resistance-in-prostate-cancer
#19
REVIEW
Alexandra Vander Ark, Jingchen Cao, Xiaohong Li
Enzalutamide, a second-generation small-molecule inhibitor of the androgen receptor (AR), has been approved for patients who failed with androgen deprivation therapy and have developed castration-resistant prostate cancer. More than 80% of these patients develop bone metastases. The binding of enzalutamide to the AR prevents the nuclear translocation of the receptor, thus inactivating androgen signaling. However, prostate cancer cells eventually develop resistance to enzalutamide treatment. Studies have found resistance both in patients and in laboratory models...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29911030/association-of-androgenetic-alopecia-with-metabolic-syndrome-a-case-control-study-on-100-patients-in-a-tertiary-care-hospital-in-south-india
#20
K C Dharam Kumar, Yadalla Hari Kishan Kumar, Vivekananda Neladimmanahally
Background: Androgenetic alopecia (AGA) is the most common cause of hair loss. Although it is a medically benign condition, it can have a significant psychosocial impact on patients. "Metabolic syndrome" (MetS) is a collection of clinical signs that focus on cardiovascular and diabetes-related parameters. Despite the high burden of AGA and MetS in India, specific data on the participants are relatively sparse. Aim of the Study: The aim of is to study the association of AGA with MetS and its parameters...
March 2018: Indian Journal of Endocrinology and Metabolism
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