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https://www.readbyqxmd.com/read/28615649/andrographolide-ameliorates-inflammation-and-fibrogenesis-and-attenuates-inflammasome-activation-in-experimental-non-alcoholic-steatohepatitis
#1
Daniel Cabrera, Alexander Wree, Davide Povero, Nancy Solís, Alejandra Hernandez, Margarita Pizarro, Han Moshage, Javiera Torres, Ariel E Feldstein, Claudio Cabello-Verrugio, Enrique Brandan, Francisco Barrera, Juan Pablo Arab, Marco Arrese
Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate the effects of ANDRO in NASH and its influence on inflammasome activation in this setting. Thus, mice were fed a choline-deficient-amino-acid-defined (CDAA) diet with/without concomitant ANDRO administration (1 mg/kg, 3-times/week)...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28609925/-i-epirrita-i-i-pulchraria-i-taylor-1907-transferred-to-i-malacodea-i-with-notes-on-the-phylogeny-and-ecology-of-the-tribe-operophterini-lepidoptera-geometridae-larentiinae
#2
Andro Truuverk, Erki Õunap, Toomas Tammaru
The Nearctic Epirrita pulchraria (Taylor, 1907) was revealed as a sister taxon of the Palaearctic Malacodea regelaria Tengström,1869 in a molecular phylogenetic analysis of the tribe Operophterini. DNA sequence variation in one mitochondrial (COI) and eight nuclear (28S, EF-1α, WGL, GAPDH, RPS5, IDH, MDH, CAD) gene fragments was used in the analysis. Bayesian inference resulted in a well-resolved phylogenetic hypothesis. According to the recovered phylogeny a new combination is proposed: Rachela pulchraria Taylor, 1907 is transferred from Epirrita Hübner, 1808 to Malacodea Tengström, 1869 as Malacodea pulchraria (Taylor, 1907) comb...
April 27, 2017: Zootaxa
https://www.readbyqxmd.com/read/28586215/experimental-and-theoretical-investigation-of-the-anti-ferromagnetic-coupling-of-cr-iii-ions-through-diamagnetic-o-nb-v-o-bridges
#3
Marijana Jurić, Lidija Androš Dubraja, Damir Pajić, Filip Torić, Andrej Zorko, Andrew Ozarowski, Vito Despoja, William Lafargue-Dit-Hauret, Xavier Rocquefelte
The synthesis and properties of a novel hetero-tetranuclear compound [Cr2(bpy)4(μ-O)4Nb2(C2O4)4]·3H2O (1; bpy = 2,2'-bipyridine), investigated by single-crystal X-ray diffraction, magnetization measurements, IR, UV/visible spectroscopy, electron paramagnetic resonance (EPR; X- and Q-bands and high-field), and density functional theory (DFT) calculations, are reported. Crystal structure of 1 (orthorhombic Pcab space group) consists of a square-shaped macrocyclic {Cr2(μ-O)4Nb2} core in which Cr(III) and Nb(V) ions are alternately bridged by oxo ions and three uncoordinated water molecules...
June 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28539838/andrographolide-inhibits-angiogenesis-by-inhibiting-the-mir-21-5p-timp3-signaling-pathway
#4
Jianwei Dai, Yuyin Lin, Youfa Duan, Zixuan Li, Dalei Zhou, Wensheng Chen, Lijing Wang, Qian-Qian Zhang
Angiogenesis provides nutrients and oxygen to promote tumor growth and affords a channel that facilitates tumor cell entry into the circulation. Andrographolide (Andro) possess anti-tumor activity; however, its direct effect on angiogenesis still needs to be clarified. In this study, our experiments revealed that Andro significantly inhibited vascular growth in chick embryo chorioallantoic membrane (CAM) and yolk sac membrane (YSM) models. Meanwhile, tumor angiogenesis was also suppressed by Andro. Additionally, we found that cell proliferation, migration and tube formation of vascular endothelial cells was inhibited by Andro treatment in vitro...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28515078/shifting-quaternary-migration-patterns-in-the-bahamian-archipelago-evidence-from-the-zamia-pumila-complex-at-the-northern-limits-of-the-caribbean-island-biodiversity-hotspot
#5
Dayana E Salas-Leiva, Alan W Meerow, Michael Calonje, Javier Francisco-Ortega, M Patrick Griffith, Kyoko Nakamura, Vanessa Sánchez, Lindy Knowles, David Knowles
PREMISE OF THE STUDY: The Bahamas archipelago is formed by young, tectonically stable carbonate banks that harbor direct geological evidence of global ice-volume changes. We sought to detect signatures of major changes on gene flow patterns and reconstruct the phylogeographic history of the monophyletic Zamia pumila complex across the Bahamas. METHODS: Nuclear molecular markers with both high and low mutation rates were used to capture two different time scale signatures and test several gene flow and demographic hypotheses...
May 17, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28485543/andrographolide-induces-cell-cycle-arrest-and-apoptosis-of-chondrosarcoma-by-targeting-tcf-1-sox9-axis
#6
Huan-Tian Zhang, Jie Yang, Gui-Hong Liang, Xue-Juan Gao, Yuan Sang, Tao Gui, Zu-Jian Liang, Man-Seng Tam, Zhen-Gang Zha
Chondrosarcoma is the second most malignant bone tumor with poor prognosis and limited treatment options. Thus, development of more effective treatments has become urgent. Recently, natural compounds derived from medicinal plants have emerged as promising therapeutic options via targeting multiple key cellular molecules. Andrographolide (Andro) is such a compound, which has previously been shown to induce cell cycle arrest and apoptosis in several human cancers. However, the molecular mechanism through which Andro exerts its anti-cancer effect on chondrosarcoma remains to be elucidated...
May 9, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28482006/predictability-and-parallelism-of-multi-trait-adaptation
#7
Randall Brian Langerhans
Environments shape the traits of organisms. Environmental variation may rarely alter selection on only a few traits, but instead precipitate wholesale changes of the multidimensional selective regime-many traits might experience divergent selection across divergent environments. Such changes in selection can elicit multifarious evolution. How predictable (from theory) and how parallel (consistent occurrences) is multi-trait divergence across replicated environments? Here, I address this question using the post-Pleistocene radiation of Bahamas mosquitofish (Gambusia hubbsi) inhabiting blue holes on Andros Island...
May 6, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/28431842/significance-of-intraoperative-findings-in-revision-tympanomastoidectomy
#8
Andro Košec, Iva Kelava, Jakov Ajduk, Mihael Ries, Robert Trotić, Vladimir Bedeković
PURPOSE: The study was designed to assess correlations between intraoperative findings in revision tympanomastoidectomy as predictors of cholesteatoma recurrence. MATERIALS AND METHODS: A retrospective single-institution cohort of 101 patients who underwent surgical treatment for recurrent chronic otitis media in a tertiary referral otology centre. RESULTS: Out of 101 patients, 65 had canal wall up and 36 canal wall down revision surgery. There were 35 cholesteatoma recurrences...
April 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28327187/schistosomiasis-is-more-prevalent-than-previously-thought-what-does-it-mean-for-public-health-goals-policies-strategies-guidelines-and-intervention-programs
#9
REVIEW
Daniel G Colley, Tamara S Andros, Carl H Campbell
Mapping and diagnosis of infections by the three major schistosome species (Schistosoma haematobium, S. mansoni and S. japonicum) has been done with assays that are known to be specific but increasingly insensitive as prevalence declines or in areas with already low prevalence of infection. This becomes a true challenge to achieving the goal of elimination of schistosomiasis because the multiplicative portion of the life-cycle of schistosomes, in the snail vector, favors continued transmission as long as even a few people maintain low numbers of worms that pass eggs in their excreta...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28325227/an-incidentaloma-in-the-cardiology-clinic
#10
Danesh K Kella, Rupak Desai, Leon Rubinsztein, Jeranfel Hernandez, Andro Kacharava
No abstract text is available yet for this article.
April 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28315464/a-novel-nanosuspension-of-andrographolide-preparation-characterization-and-passive-liver-target-evaluation-in-rats
#11
Ligang Guo, Le Kang, Xinrong Liu, Xiangyun Lin, Donghua Di, Yong Wu, Dexian Kong, Yihui Deng, Yanzhi Song
Andrographolide (Andro) is an excellent anti-inflammatory bicyclic diterpene γ-lactone. However, the poor solubility limits its application as injection for the treatment of acute inflammation. To meet the clinical needs for emergency, the Andro nanosuspensions injection was first prepared by the wet milling technique. The Andro nanosuspensions were composed of 3% Andro, 5% poloxamer 188 as the non-ionic stabilizer, 0.05% sodium deoxycholate or 0.1% sodium tauroursodeoxy cholate as the ionic stabilizer, and prepared by 350rpm speed and 12cycles of grinding with 0...
June 15, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28212886/primary-ameloblastoma-of-the-temporal-bone
#12
Andro Košec, Jakov Ajduk, Mihael Ries, Robert Trotić
Ameloblastoma is a locally aggressive tumor derived from odontogenic epithelium. Although benign, its clinical behavior can often exhibit malignant characteristics. It is marked by slow and persistent growth with infiltration of adjacent tissues. Almost 70% occur in the mandible in patients older than 30 years. Recurrence of ameloblastoma from inadequate treatment is frequent. Because of its slow growth, recurrences can present decades after primary surgery. A primary ameloblastoma in an area outside the mandibular, maxillary, and infratemporal fossa regions has not been described in detail to date, with only 1 possible case mentioned in the literature...
June 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28199632/people-s-corner-tiny-jaarsma-phdthe-2016-american-heart-association-distinguished-scientist-award
#13
Andros Tofield
No abstract text is available yet for this article.
February 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28199630/end-of-the-road-for-aliskiren-in-heart-failure
#14
Andros Tofield
No abstract text is available yet for this article.
February 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28193824/correction-to-eco-evolutionary-dynamics-in-urbanized-landscapes-evolution-species-sorting-and-the-change-in-zooplankton-body-size-along-urbanization-gradients
#15
Kristien I Brans, Lynn Govaert, Jessie M T Engelen, Andros T Gianuca, Caroline Souffreau, Luc De Meester
No abstract text is available yet for this article.
April 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28182713/taxifolin-synergizes-andrographolide-induced-cell-death-by-attenuation-of-autophagy-and-augmentation-of-caspase-dependent-and-independent-cell-death-in-hela-cells
#16
Mazen Alzaharna, Iyad Alqouqa, Hon-Yeung Cheung
Andrographolide (Andro) has emerged recently as a potential and effective anticancer agent with induction of apoptosis in some cancer cell lines while induction of G2/M arrest with weak apoptosis in others. Few studies have proved that Andro is also effective in combination therapy. The flavonoid Taxifolin (Taxi) has showed anti-oxidant and antiproliferative effects against different cancer cells. Therefore, the present study investigated the cytotoxic effects of Andro alone or in combination with Taxi on HeLa cells...
2017: PloS One
https://www.readbyqxmd.com/read/28164514/testosterone-measured-with-an-automatic-immunoassay-compares-reasonably-well-to-results-obtained-by-lc-ms-ms
#17
Cindy S Knudsen, Carsten S Hoejskov, Holger J Moller, Ebba Nexo
BACKGROUND: Previous studies have reported problems measuring testosterone with immunological assays. Here we explore an automatic second generation immunoassay compared to a LC-MS/MS method. METHODS: We collected blood samples from 76 women and measured testosterone, progesterone, gender hormonebinding globulin (SHBG), and albumin employing Cobas e601/c501. Testosterone, androstenedione (andro), dehydroepiandrosterone sulphate (DHEAS), and 17-hydroxyprogesterone (17-OHP) concentrations were measured employing LC-MS/MS...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28116742/evaluation-of-ros-tac-score-and-dna-damage-in-fertile-normozoospermic-and-infertile-asthenozoospermic-males
#18
Akram Vatannejad, Heidar Tavilani, Mohammad Reza Sadeghi, Saeid Amanpour, Somyeh Shapourizadeh, Mahmood Doosti
PURPOSE: The aim of study was to evaluate reactive oxygen species (ROS), total antioxidant capacity (TAC) andROS-TAC score as indicator for oxidative stress status as well as 8-hydrodeoxyguanosine (8-OHdG) levels as amarker for DNA damage in the seminal plasma of asthenozoospermia patients compared to normozoospermiasamples. MATERIALS AND METHODS: The semen samples of 28 fertile normozoospermic donors and 25 infertile men withasthenozoospermia were analyzed according to World Health Organization (WHO) criteria...
January 18, 2017: Urology Journal
https://www.readbyqxmd.com/read/28110305/christina-fanola-md-msc
#19
Andros Tofield
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28097636/andrographolide-antibacterial-activity-against-common-bacteria-of-human-health-concern-and-possible-mechanism-of-action
#20
Malabika Banerjee, Debaprasad Parai, Subrata Chattopadhyay, Samir Kumar Mukherjee
Increasing bacterial resistance to common drugs is a major public health concern for the treatment of infectious diseases. Certain naturally occurring compounds of plant sources have long been reported to possess potential antimicrobial activity. This study was aimed to investigate the antibacterial activity and possible mechanism of action of andrographolide (Andro), a diterpenoid lactone from a traditional medicinal herb Andrographis paniculata. Extent of antibacterial action was assessed by minimal bactericidal concentration method...
May 2017: Folia Microbiologica
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