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https://www.readbyqxmd.com/read/29232451/commemorative-mural-in-cape-town-a-new-mural-of-african-themes-was-inaugurated-at-the-faculty-of-health-sciences-art-exhibition-in-cape-town-to-celebrate-chris-barnard-s-epic-first-human-heart-transplant-50%C3%A2-years-ago
#1
https://www.readbyqxmd.com/read/29200829/andrographolide-enhanced-5-fluorouracil-induced-antitumor-effect-in-colorectal-cancer-via-inhibition-of-c-met-pathway
#2
Meng Su, Baoli Qin, Fang Liu, Yuze Chen, Rui Zhang
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. 5-Fluorouracil (5-Fu) is the most important chemotherapeutic drug used for the treatment of CRC. However, resistance to 5-Fu therapies is a growing concern in CRC clinical practice recently. Andrographolide (Andro) is a main bioactive constituent of the herb Andrographis paniculata, which has various biological effects including anti-inflammation and antitumor activities. In the present study, we investigated the effects of combined Andro with 5-Fu against CRC HCT-116 cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29177415/esc-cardiomed-the-new-esc-textbook-of-cardiovascular-medicine-an-innovative-digital-textbook-database-for-today-s-cardiologists-from-the-european-society-of-cardiology-will-soon-be-available
#3
https://www.readbyqxmd.com/read/29134011/the-larvae-of-sericostoma-bergeri-malicky-1973-and-sericostoma-herakles-malicky-1999-trichoptera-sericostomatidae
#4
Johann Waringer, Hans Malicky
This paper describes the previously unknown larvae of Sericostoma bergeri and S. herakles (Trichoptera: Sericostomatidae) restricted to European Ecoregion 6 (= Hellenic western Balkan). Information on the morphology of the larvae is given, and the most important diagnostic features are illustrated. Sericostoma bergeri and S. herakles can be easily separated from known sericostomatid larvae of Ecoregion 6 (Schizopelex huettingeri, Oecismus monedula, Sericostoma flavicorne and S. personatum) by the shape of the pronotum, presence or lack of a comma-like marking on the lateral protuberance, by the number of setae on abdominal dorsum IX, and by distribution patterns...
2017: ZooKeys
https://www.readbyqxmd.com/read/29112590/effect-of-andrographolide-on-gene-expression-profile-and-intracellular-calcium-in-primary-rat-myocardium-microvascular-endothelial-cells
#5
Bo Feng, Qian Zhang, Xin Wang, Xiangwan Sun, Xiang Mu, Hong Dong
Andrographolide (ANDRO) is a diterpene lactone compound with extensive biological effects, such as antibacterial, antitumor and treatment of cardiovascular diseases. Until now, studies on the pharmacological functions of ANDRO are still in progress. However, little is known about the gene expression profile and calcium response of endothelial cells to ANDRO. In this study, we used a microarray technology to investigate the gene expression responses in primary rat myocardium microvascular endothelial cells (RMMECs) treated with 10μg/mL ANDRO...
October 31, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29099986/heart-failure-congress-sets-record-the-2017-esc-heart-failure-association-congress-had-a-new-record-number-of-submissions-for-original-science
#6
Andros Tofield
No abstract text is available yet for this article.
November 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29048499/sylvia-priori-researcher-and-cardiologist
#7
Andros Tofield
No abstract text is available yet for this article.
October 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28938727/professor-alfredo-r-galassi-md-facc-fesc-fscai
#8
Andros Tofield
No abstract text is available yet for this article.
March 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934087/high-risk-behaviours-for-the-f%C3%A5-tus-in-pregnant-women-the-medicolegal-and-judicial-aspects
#9
P Desaunay, A Cerf-Hollender, G Andro, P Gerardin, M Dreyfus, F Guenole
Pregnancy is a period of psychological change which may lead to difficulties of adaptation and psychological suffering and give rise to high-risk behaviours for the fœtus in pregnant women. These risk behaviours, which are defined by certain authors as a form of "maltreatment" of the fœtus, usually spring from the psychological distress of the pregnant woman but are not recognised as a specific medical disorder. We illustrate the difficulties encountered in the identification of, and the specific intervention in, these situations through the clinical case of a pregnant drugs-dependent patient subjected to several stress factors who, in addition to consuming substances, developed high-risk behaviours for herself and her pregnancy: self-endangerment under the influence of substances, falls or refusals of treatment...
May 2017: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/28929042/the-physical-examination-does-matter-a-case-of-spontaneous-aortocaval-fistula
#10
Rupak Desai, Mikhail Akbashev, Leon Rubinsztain, Andro G Kacharava
A spontaneous aortocaval fistula is a rare complication of abdominal aortic aneurysms. In 50 percent of the patients, it presents with the classic signs of a pulsatile abdominal mass, continuous bruit, and low back pain. A high degree of clinical suspicion and a well-performed physical examination are important for its timely diagnosis.
July 11, 2017: Curēus
https://www.readbyqxmd.com/read/28903481/what-academic-research-captured-the-public-s-imagination-in-2016
#11
Andros Tofield
No abstract text is available yet for this article.
September 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28869219/andrographolide-sensitizes-prostate-cancer-cells-to-trail-induced-apoptosis
#12
Ruo-Jing Wei, Xin-Shi Zhang, Da-Lin He
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer therapy. The identification of small molecules that can establish the sensitivity of prostate cancer (PCa) cells to TRAIL-induced apoptosis is crucial for the targeted treatment of PCa. PC3, DU145, JAC-1, TsuPr1, and LNCaP cells were treated with Andrographolide (Andro) and TRAIL, and the apoptosis was measured using the Annexin V/PI double staining method. Real time-polymerase chain reaction (PCR) and Western blot analysis were performed to measure the expression levels of target molecules...
September 1, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28838060/cardiac-patients-and-electronic-anti-theft-systems
#13
Andros Tofield
No abstract text is available yet for this article.
July 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28838056/rhythm-for-life-in-germany
#14
Andros Tofield
No abstract text is available yet for this article.
July 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28828439/the-influence-of-metal-centres-on-the-exchange-interaction-in-heterometallic-complexes-with-oxalate-bridged-cations
#15
Lidija Androš Dubraja, Marijana Jurić, Filip Torić, Damir Pajić
The reaction of bis(phenanthroline)metal(ii) cations (M = Mn(2+), Co(2+), Ni(2+), Cu(2+) and Zn(2+)) with bis(oxalato)chromium(iii) anions in a water/ethanol solution gives rise to a series of compounds with oxalate-bridged cations, [{M(phen)2}2(μ-C2O4)][Cr(phen)(C2O4)2]2·4H2O [Mn2Cr2 (1), Co2Cr2 (2), Ni2Cr2 (3), Cu2Cr2 (4) and Zn2Cr2 (5)]. Their structural analysis reveals that all the prepared compounds crystallize in the triclinic system, space group P1[combining macron], having similar unit cell parameters, molecular structures and crystal packing features...
September 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28821176/sabine-ernst-md-phd-fesc
#16
Andros Tofield
No abstract text is available yet for this article.
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28810674/carina-blomstr%C3%A3-m-lundqvist
#17
Andros Tofield
No abstract text is available yet for this article.
August 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28766734/pressure-flow-pattern-of-varicocele-veins-and-its-correlation-with-testicular-blood-flow-and-semen-parameters
#18
K Ur Rehman, A B Qureshi, A Numan, H Zaneb, M S Yousaf, I Rabbani, H Rehman
The pressure pattern in varicocele veins of infertile patients and its correlation with semen quality and testicular blood flow was determined. Consecutive patients at andro-urology clinic of a teaching hospital undergoing microsurgical varicocelectomy were included. Their semen quality and testicular blood flow were determined. Peak systolic velocity (PSV) and resistive index (RI) of subcapsular and intraparenchymal branches of testicular artery were noted by colour Doppler ultrasonography. During surgery before ligation of varicocele veins, intravenous pressures of internal spermatic (ISV) and external spermatic (ESV) veins were determined at baseline and after Valsalva manoeuvre...
August 2, 2017: Andrologia
https://www.readbyqxmd.com/read/28761261/presence-of-mast-cells-and-mast-cell-degranulation-in-scalp-biopsies-of-telogen-effluvium
#19
Shane A Grace, Angela M Sutton, Nina Abraham, Eric S Armbrecht, Claudia I Vidal
BACKGROUND: Telogen effluvium (TE) is a type of acquired, diffuse alopecia that occurs due to an abnormal shift of scalp hair follicles from anagen to telogen, leading to premature shedding of hair. Previous studies have suggested the existence of a neuroimmunologic "brain-hair follicle" axis, in which mast cells have been implicated as an important link between the nervous system and immunologic system. OBJECTIVE: The current study sought to investigate the role of mast cell presence and mast cell degranulation in the pathogenesis of TE...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28739368/andrographolide-induces-oxidative-stress-dependent-cell-death-in-unicellular-protozoan-parasite-trypanosoma-brucei
#20
Malabika Banerjee, Debaprasad Parai, Pranab Dhar, Manab Roy, Rajib Barik, Subrata Chattopadhyay, Samir Kumar Mukherjee
African sleeping sickness is a parasitic disease in humans and livestock caused by Trypanosoma brucei throughout sub-Saharan Africa. Absence of appropriate vaccines and prevalence of drug resistance proclaim that a new way of therapeutic interventions is essential against African trypanosomiasis. In the present study, we have looked into the effect of andrographolide (andro), a diterpenoid lactone from Andrographis paiculata on Trypanosoma brucei PRA 380. Although andro has been recognized as a promosing anti-cancer drug, its usefulness against Trypanosoma spp remained unexplored...
December 2017: Acta Tropica
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