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Guo Liu, Haihan Chu
Andrographolide (Andro), a natural compound isolated from Andrographis paniculata , has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using an MTT assay and the effect of Andro on the cell cycle and apoptosis of human malignant melanoma cells was determined by flow cytometry. Western blot analysis was performed to evaluate the protein expression levels of human malignant melanoma cells following treatment with Andro...
April 2018: Oncology Letters
Andros Tofield
No abstract text is available yet for this article.
March 1, 2018: European Heart Journal
Marijana Jurić, Lidija Androš Dubraja, Jasminka Popović, Krešimir Molčanov, Filip Torić, Damir Pajić, Ivor Lončarić
Three heterometallic oxo-bridged compounds, [Cr2 (phen)4 (μ-O)4 Nb2 (C2 O4 )4 ]·2H2 O (1; phen = 1,10-phenanthroline), [Cr2 (terpy)2 (H2 O)2 (μ-O)4 Nb2 (C2 O4 )4 ]·4H2 O (2; terpy = 2,2';6',2''-terpyridine) and [Cr(terpy)(C2 O4 )(H2 O)][Cr2 (terpy)2 (C2 O4 )2 (μ-O)2 Nb(C2 O4 )2 ]·3H2 O (3), have been synthesized using a building block approach and characterized by IR spectroscopy, single-crystal and powder X-ray diffraction, magnetization measurements, and DFT calculations. The molecular structures of 1 and 2, crystallizing in P42 21 2 and P21 /n space groups, respectively, contain a square-shaped {Cr(μ-O)4 Nb} unit, while that of complex salt 3 (P1[combining macron] space group) consists of a mononuclear cation containing CrIII and trinuclear anions in which two CrIII ions are bridged by a -O-NbV -O- fragment...
February 26, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Andros Tofield
No abstract text is available yet for this article.
February 21, 2018: European Heart Journal
L Androš Dubraja, M Jurić, J Popović, D Pajić, Y Krupskaya, V Kataev, B Bűchner, D Žilić
The results of high-field electron spin resonance (HF-ESR) spectroscopy on the title 1D coordination polymers at frequencies up to 415 GHz, supported by X-ray diffraction, thermal, magnetic susceptibility, and X-band (10 GHz) ESR studies, are presented. The heterometallic compounds {SrCr2 (phen)2 (C2 O4 )4 }·H2 O (SrCrPhen) and {SrCr2 (bpy)2 (C2 O4 )4 (H2 O)}·5H2 O (SrCrBpy) (phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine) were synthesized. Structural analysis revealed double oxalate-bridged zigzag Sr-Cr chains while magnetic susceptibility studies showed paramagnetic behaviour of the complexes...
February 21, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Erika Testa, Daniela Nardozi, Cristina Antinozzi, Monica Faieta, Stefano Di Cecca, Cinzia Caggiano, Tomoyuki Fukuda, Elena Bonanno, Lou Zhenkun, Andros Maldonado, Ignasi Roig, Monica Di Giacomo, Marco Barchi
In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. By analyzing chromosome dynamics in H2afx -/- spermatocytes, we found that the synapsis of autosomes and X-Y chromosomes was impaired in a relevant fraction of cells. Such defect correlated with an abnormal recombination profile. Conversely, Mdc1 was dispensable for the synapsis of the autosomes, and only played a minor role in X-Y synapsis, relatively to H2afx This suggested that those genes have non-overlapping functions in chromosome synapsis...
February 7, 2018: Journal of Cell Science
Huang-Chi Wang, Hsin-Sheng Tsay, Hui-Nung Shih, Yi-An Chen, Kai-Ming Chang, Dinesh Chandra Agrawal, Siendong Huang, Yi-Lo Lin, Meng-Jen Lee
CONTEXT: Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia. OBJECTIVE: The objective of this study is to test Andro's ability to reduce allodynia in a spared nerve injury model. MATERIAL AND METHODS: Male 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group); (4) nerve injured and treated with non-steroidal anti-inflammatory drugs (NSAIDS) (NSAIDS-group)...
December 2018: Pharmaceutical Biology
Hongyu Yan, Zhenlin Huang, Qingyun Bai, Yuchen Sheng, Zhanxia Hao, Zhengtao Wang, Lili Ji
As a well-known analgesic drug, acetaminophen (APAP) is commonly used to relieve pain for patients with chronic painful diseases. Our previous study has shown that long-term ingestion of APAP caused liver fibrosis in mice. This study further investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating APAP-induced liver fibrosis in mice and the anti-fibrotic effect of natural compound andrographolide (Andro). Our results showed that hepatic collagen deposition and hepatic stellate cells (HSCs) activation induced by APAP were more serious in Nrf2 knock-out mice than in normal wild-type mice...
March 1, 2018: Toxicology
Gwénäelle Andro
The 'separation-individuation' group is offered to children aged between three and five, in outpatient consultations with a paediatric psychiatrist. It was created following the testimonies of early childhood professionals describing the feeling on the part of parents of being torn from their child, during the first year of school. Open and held on a weekly basis, it is combined with a parents' meeting organised simultaneously. The individualised group tool supports the separation-individuation process when this is particularly painful, for the child and the parents...
January 2018: Soins. Pédiatrie, Puériculture
Ludmila Bercaire, Sara Mb Nogueira, Priscila Cm Lima, Vanessa R Alves, Nilka Donadio, Artur Dzik, Mario Cavagna
OBJECTIVE: This study aimed to assess a novel protocol designed to improve poor ovarian response through intra-ovarian androgenization. The endpoints were: number of oocytes and mature oocytes retrieved, fertilization, cancellation and pregnancy rates. METHODS: This prospective crossover study enrolled poor responders from previous ovarian stimulation cycles submitted to a novel protocol called ANDRO-IVF. The protocol included pretreatment with transdermal AndroGel(r) (Besins) 25 mg, oral letrozole 2...
March 1, 2018: JBRA Assisted Reproduction
Andros Tofield
No abstract text is available yet for this article.
January 1, 2018: European Heart Journal
Andros Theo, Stefano Tempia, Adam L Cohen, Paul Simusika, Edward Chentulo, Chikama Mukwangole Chikamukwa, Mwaka Monze
BACKGROUND: Estimates of influenza-associated hospitalization are limited in low- and middle-income countries, especially in Africa. OBJECTIVE: To estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Zambia. METHODS: We conducted active prospective hospital-based surveillance for SARI at the University Teaching Hospital (UTH) situated in Lusaka Province during 2011-2014. Upper respiratory tract samples were tested for influenza virus using a reverse transcriptase polymerase chain reaction assay...
January 2018: Influenza and Other Respiratory Viruses
M E Prévôt, H Andro, S L M Alexander, S Ustunel, C Zhu, Z Nikolov, S T Rafferty, M T Brannum, B Kinsel, L T J Korley, E J Freeman, J A McDonough, R J Clements, E Hegmann
Tissue regeneration requires 3-dimensional (3D) smart materials as scaffolds to promote transport of nutrients. To mimic mechanical properties of extracellular matrices, biocompatible polymers have been widely studied and a diverse range of 3D scaffolds have been produced. We propose the use of responsive polymeric materials to create dynamic substrates for cell culture, which goes beyond designing only a physical static 3D scaffold. Here, we demonstrated that lactone- and lactide-based star block-copolymers (SBCs), where a liquid crystal (LC) moiety has been attached as a side-group, can be crosslinked to obtain Liquid Crystal Elastomers (LCEs) with a porous architecture using a salt-leaching method to promote cell infiltration...
January 17, 2018: Soft Matter
Jared L Ostroff, Marissa L Wolff, Christina Andros, Eric C Nemec
BACKGROUND AND PURPOSE: The purpose of this article is to describe a service learning experience involving tobacco prevention education and to measure the education's effect on the learners' knowledge of tobacco products. EDUCATIONAL ACTIVITY AND SETTING: Student pharmacists planned and presented a 40-min tobacco prevention education program using the Tar Wars curriculum to fourth and fifth grade students at three suburban elementary schools in Western Massachusetts...
September 2017: Currents in Pharmacy Teaching & Learning
Meng Su, Baoli Qin, Fang Liu, Yuze Chen, Rui Zhang
Colorectal cancer (CRC) is the third most common malignant neoplasm worldwide. 5-Fluorouracil (5-Fu) is the most important chemotherapeutic drug used for the treatment of CRC. However, resistance to 5-Fu therapies is a growing concern in CRC clinical practice recently. Andrographolide (Andro) is a main bioactive constituent of the herb Andrographis paniculata , which has various biological effects including anti-inflammation and antitumor activities. In the present study, we investigated the effects of combined Andro with 5-Fu against CRC HCT-116 cells...
2017: Drug Design, Development and Therapy
Johann Waringer, Hans Malicky
This paper describes the previously unknown larvae of Sericostoma bergeri and S. herakles (Trichoptera: Sericostomatidae) restricted to European Ecoregion 6 (= Hellenic western Balkan). Information on the morphology of the larvae is given, and the most important diagnostic features are illustrated. Sericostoma bergeri and S. herakles can be easily separated from known sericostomatid larvae of Ecoregion 6 ( Schizopelex huettingeri , Oecismus monedula , Sericostoma flavicorne and S. personatum ) by the shape of the pronotum, presence or lack of a comma-like marking on the lateral protuberance, by the number of setae on abdominal dorsum IX, and by distribution patterns...
2017: ZooKeys
Bo Feng, Qian Zhang, Xin Wang, Xiangwan Sun, Xiang Mu, Hong Dong
Andrographolide (ANDRO) is a diterpene lactone compound with extensive biological effects, such as antibacterial, antitumor and treatment of cardiovascular diseases. Until now, studies on the pharmacological functions of ANDRO are still in progress. However, little is known about the gene expression profile and calcium response of endothelial cells to ANDRO. In this study, we used a microarray technology to investigate the gene expression responses in primary rat myocardium microvascular endothelial cells treated with 10 μg/mL ANDRO...
December 2017: Journal of Cardiovascular Pharmacology
Andros Tofield
No abstract text is available yet for this article.
November 1, 2017: European Heart Journal
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