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https://www.readbyqxmd.com/read/29048499/sylvia-priori-researcher-and-cardiologist
#1
Andros Tofield
No abstract text is available yet for this article.
October 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28938727/professor-alfredo-r-galassi-md-facc-fesc-fscai
#2
Andros Tofield
No abstract text is available yet for this article.
March 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28934087/high-risk-behaviours-for-the-f%C3%A5-tus-in-pregnant-women-the-medicolegal-and-judicial-aspects
#3
P Desaunay, A Cerf-Hollender, G Andro, P Gerardin, M Dreyfus, F Guenole
Pregnancy is a period of psychological change which may lead to difficulties of adaptation and psychological suffering and give rise to high-risk behaviours for the fœtus in pregnant women. These risk behaviours, which are defined by certain authors as a form of "maltreatment" of the fœtus, usually spring from the psychological distress of the pregnant woman but are not recognised as a specific medical disorder. We illustrate the difficulties encountered in the identification of, and the specific intervention in, these situations through the clinical case of a pregnant drugs-dependent patient subjected to several stress factors who, in addition to consuming substances, developed high-risk behaviours for herself and her pregnancy: self-endangerment under the influence of substances, falls or refusals of treatment...
May 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28929042/the-physical-examination-does-matter-a-case-of-spontaneous-aortocaval-fistula
#4
Rupak Desai, Mikhail Akbashev, Leon Rubinsztain, Andro G Kacharava
A spontaneous aortocaval fistula is a rare complication of abdominal aortic aneurysms. In 50 percent of the patients, it presents with the classic signs of a pulsatile abdominal mass, continuous bruit, and low back pain. A high degree of clinical suspicion and a well-performed physical examination are important for its timely diagnosis.
July 11, 2017: Curēus
https://www.readbyqxmd.com/read/28903481/what-academic-research-captured-the-public-s-imagination-in-2016
#5
Andros Tofield
No abstract text is available yet for this article.
September 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28869219/andrographolide-sensitizes-prostate-cancer-cells-to-trail-induced-apoptosis
#6
Ruo-Jing Wei, Xin-Shi Zhang, Da-Lin He
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising agent for anticancer therapy. The identification of small molecules that can establish the sensitivity of prostate cancer (PCa) cells to TRAIL-induced apoptosis is crucial for the targeted treatment of PCa. PC3, DU145, JAC-1, TsuPr1, and LNCaP cells were treated with Andrographolide (Andro) and TRAIL, and the apoptosis was measured using the Annexin V/PI double staining method. Real time-polymerase chain reaction (PCR) and Western blot analysis were performed to measure the expression levels of target molecules...
September 1, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/28838060/cardiac-patients-and-electronic-anti-theft-systems
#7
Andros Tofield
No abstract text is available yet for this article.
July 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28838056/rhythm-for-life-in-germany
#8
Andros Tofield
No abstract text is available yet for this article.
July 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28828439/the-influence-of-metal-centres-on-the-exchange-interaction-in-heterometallic-complexes-with-oxalate-bridged-cations
#9
Lidija Androš Dubraja, Marijana Jurić, Filip Torić, Damir Pajić
The reaction of bis(phenanthroline)metal(ii) cations (M = Mn(2+), Co(2+), Ni(2+), Cu(2+) and Zn(2+)) with bis(oxalato)chromium(iii) anions in a water/ethanol solution gives rise to a series of compounds with oxalate-bridged cations, [{M(phen)2}2(μ-C2O4)][Cr(phen)(C2O4)2]2·4H2O [Mn2Cr2 (1), Co2Cr2 (2), Ni2Cr2 (3), Cu2Cr2 (4) and Zn2Cr2 (5)]. Their structural analysis reveals that all the prepared compounds crystallize in the triclinic system, space group P1[combining macron], having similar unit cell parameters, molecular structures and crystal packing features...
September 12, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28821176/sabine-ernst-md-phd-fesc
#10
Andros Tofield
No abstract text is available yet for this article.
August 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28810674/carina-blomstr%C3%A3-m-lundqvist
#11
Andros Tofield
No abstract text is available yet for this article.
August 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28766734/pressure-flow-pattern-of-varicocele-veins-and-its-correlation-with-testicular-blood-flow-and-semen-parameters
#12
K Ur Rehman, A B Qureshi, A Numan, H Zaneb, M S Yousaf, I Rabbani, H Rehman
The pressure pattern in varicocele veins of infertile patients and its correlation with semen quality and testicular blood flow was determined. Consecutive patients at andro-urology clinic of a teaching hospital undergoing microsurgical varicocelectomy were included. Their semen quality and testicular blood flow were determined. Peak systolic velocity (PSV) and resistive index (RI) of subcapsular and intraparenchymal branches of testicular artery were noted by colour Doppler ultrasonography. During surgery before ligation of varicocele veins, intravenous pressures of internal spermatic (ISV) and external spermatic (ESV) veins were determined at baseline and after Valsalva manoeuvre...
August 2, 2017: Andrologia
https://www.readbyqxmd.com/read/28761261/presence-of-mast-cells-and-mast-cell-degranulation-in-scalp-biopsies-of-telogen-effluvium
#13
Shane A Grace, Angela M Sutton, Nina Abraham, Eric S Armbrecht, Claudia I Vidal
BACKGROUND: Telogen effluvium (TE) is a type of acquired, diffuse alopecia that occurs due to an abnormal shift of scalp hair follicles from anagen to telogen, leading to premature shedding of hair. Previous studies have suggested the existence of a neuroimmunologic "brain-hair follicle" axis, in which mast cells have been implicated as an important link between the nervous system and immunologic system. OBJECTIVE: The current study sought to investigate the role of mast cell presence and mast cell degranulation in the pathogenesis of TE...
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28739368/andrographolide-induces-oxidative-stress-dependent-cell-death-in-unicellular-protozoan-parasite-trypanosoma-brucei
#14
Malabika Banerjee, Debaprasad Parai, Pranab Dhar, Manab Roy, Rajib Barik, Subrata Chattopadhyay, Samir Kumar Mukherjee
African sleeping sickness is a parasitic disease in humans and livestock caused by Trypanosoma brucei throughout sub-Saharan Africa. Absence of appropriate vaccines and prevalence of drug resistance proclaim that a new way of therapeutic interventions is essential against African trypanosomiasis. In the present study, we have looked into the effect of andrographolide (andro), a diterpenoid lactone from Andrographis paiculata on Trypanosoma brucei PRA 380. Although andro has been recognized as a promosing anti-cancer drug, its usefulness against Trypanosoma spp remained unexplored...
December 2017: Acta Tropica
https://www.readbyqxmd.com/read/28692436/andrographolide-enhances-cisplatin-mediated-anticancer-effects-in-lung-cancer-cells-through-blockade-of-autophagy
#15
Daolu Yuwen, Shanwei Mi, Yuzhu Ma, Wenjie Guo, Qiang Xu, Yan Shen, Yongqian Shu
Lung cancer is the most common cause of cancer-related death worldwide and the platinum-based drugs such as cisplatin have been used as the first line of the treatment. However, the clinical effectiveness of such chemotherapy is limited by intrinsic or acquired resistance. In this study, we found that cisplatin induced autophagy that attenuated the sensitivity of both A549 and Lewis lung cancer (LLC) cells to cisplatin. In contrast, the clinical drug andrographolide (Andro) suppressed autophagy and enhanced cisplatin-mediated apoptosis in these cells...
July 7, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28684414/kinetic-processivity-of-the-two-step-oxidations-of-progesterone-and-pregnenolone-to-androgens-by-human-cytochrome-p450-17a1
#16
COMPARATIVE STUDY
Eric Gonzalez, F Peter Guengerich
Cytochrome P450 (P450, CYP) 17A1 plays a critical role in steroid metabolism, catalyzing both the 17α-hydroxylation of pregnenolone and progesterone and the subsequent 17α,20-lyase reactions to form dehydroepiandrosterone (DHEA) and androstenedione (Andro), respectively, critical for generating glucocorticoids and androgens. Human P450 17A1 reaction rates examined are enhanced by the accessory protein cytochrome b5 (b5), but the exact role of b5 in P450 17A1-catalyzed reactions is unclear as are several details of these reactions...
August 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28669260/andrographolide-attenuates-microglia-mediated-a%C3%AE-neurotoxicity-partially-through-inhibiting-nf-%C3%AE%C2%BAb-and-jnk-mapk-signaling-pathway
#17
Rui Yang, Sha Liu, Jia Zhou, Shuhong Bu, Jian Zhang
Neuroinflammation plays a critical role in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease (AD). Microglial cells after activated play critical roles in development of neuroinflammation, and may accelerate the progression of AD. Andrographolide (ANDRO), a potent naturally extracted substance, has been demonstrated to exert suppressive effects on LPS-induced inflammation by modulating macrophage and microglia overactivation. Whereas in AD, β-amyloid (Aβ) peptides have been considered as a potent activator of neuroinflammation, the effect of ANDRO on Aβ-induced neuroinflammation has not been examined...
July 18, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/28652943/diverse-habitat-use-during-two-life-stages-of-the-critically-endangered-bahama-oriole-icterus-northropi-community-structure-foraging-and-social-interactions
#18
Melissa R Price, William K Hayes
Our ability to prevent extinction in declining populations often depends on effective management of habitats that are disturbed through wildfire, logging, agriculture, or development. In these disturbed landscapes, the juxtaposition of multiple habitat types can be especially important to fledglings and young birds, which may leave breeding grounds in human-altered habitat for different habitats nearby that provide increased foraging opportunities, reduced competition, and higher protection from predators. In this study, we evaluated the importance of three habitat types to two life stages of the critically endangered Bahama Oriole (Icterus northropi), a synanthropic songbird endemic to Andros, The Bahamas...
2017: PeerJ
https://www.readbyqxmd.com/read/28651835/andrographolide-reduced-vegfa-expression-in-hepatoma-cancer-cells-by-inactivating-hif-1%C3%AE-the-involvement-of-jnk-and-mta1-hdca
#19
Liang Shi, Guoqing Zhang, Zhiyong Zheng, Bin Lu, Lili Ji
Andrographolide (Andro) is the main active compound in medicinal herb Andrographis paniculata Nees (Acanthaceae). Vascular endothelial growth factor A (VEGFA), a key pro-angiogenic factor, contributes greatly to tumor growth. The purpose of this study is to observe the inhibition of Andro on VEGFA expression in hepatoma cancer cells and its engaged mechanism. Andro decreased mRNA and protein expression of VEGFA in hepatoma Hep3B and HepG2 cells. Andro also decreased hypoxia-inducible factor 1-alpha (HIF-1α) protein expression and its subsequent nuclear translocation...
August 1, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28615649/andrographolide-ameliorates-inflammation-and-fibrogenesis-and-attenuates-inflammasome-activation-in-experimental-non-alcoholic-steatohepatitis
#20
Daniel Cabrera, Alexander Wree, Davide Povero, Nancy Solís, Alejandra Hernandez, Margarita Pizarro, Han Moshage, Javiera Torres, Ariel E Feldstein, Claudio Cabello-Verrugio, Enrique Brandan, Francisco Barrera, Juan Pablo Arab, Marco Arrese
Therapy for nonalcoholic steatohepatitis (NASH) is limited. Andrographolide (ANDRO), a botanical compound, has a potent anti-inflammatory activity due to its ability to inhibit NF-κB. ANDRO has been also shown to inhibit the NLRP3 inflammasome, a relevant pathway in NASH. Our aim was to evaluate the effects of ANDRO in NASH and its influence on inflammasome activation in this setting. Thus, mice were fed a choline-deficient-amino-acid-defined (CDAA) diet with/without concomitant ANDRO administration (1 mg/kg, 3-times/week)...
June 14, 2017: Scientific Reports
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