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https://www.readbyqxmd.com/read/29905816/milton-packer-md
#1
Andros Tofield
No abstract text is available yet for this article.
June 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29878171/connecting-the-pieces-of-takotsubo-broken-heart
#2
Andros Tofield
No abstract text is available yet for this article.
June 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29860371/nazzareno-gali%C3%A3-md-fesc-nazzareno-gali%C3%A3-has-joined-the-ehj-as-a-new-international-associate-editor
#3
Andros Tofield
No abstract text is available yet for this article.
June 1, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29859638/risks-and-benefits-of-local-anesthesia-versus-general-anesthesia-in-tonsillectomy
#4
Filip Matovinović, Filip Bacan, Elvira Kereković, Alan Pegan, Ivan Rašić, Andro Košec
PURPOSE: Tonsillectomy is one of the most common surgical procedures in otorhinolaryngology. Modern general anesthetic techniques have reduced surgical risks, but performing the procedure under local anesthesia may still offer significant benefit for both the patient and surgeon. This study analyzed the risks and benefits of performing tonsillectomies under local anesthesia. METHODS: This is a retrospective longitudinal cohort study analyzing postoperative bleeding rates as a primary outcome measure...
May 26, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29845212/andrographolide-induces-degradation-of-mutant-p53-via-activation-of-hsp70
#5
Hirofumi Sato, Masatsugu Hiraki, Takushi Namba, Noriyuki Egawa, Koichi Baba, Tomokazu Tanaka, Hirokazu Noshiro
The tumor suppressor gene p53 encodes a transcription factor that regulates various cellular functions, including DNA repair, apoptosis and cell cycle progression. Approximately half of all human cancers carry mutations in p53 that lead to loss of tumor suppressor function or gain of functions that promote the cancer phenotype. Thus, targeting mutant p53 as an anticancer therapy has attracted considerable attention. In the current study, a small-molecule screen identified andrographlide (ANDRO) as a mutant p53 suppressor...
May 22, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29795350/body-size-shifts-in-aquatic-and-terrestrial-urban-communities
#6
Thomas Merckx, Caroline Souffreau, Aurélien Kaiser, Lisa F Baardsen, Thierry Backeljau, Dries Bonte, Kristien I Brans, Marie Cours, Maxime Dahirel, Nicolas Debortoli, Katrien De Wolf, Jessie M T Engelen, Diego Fontaneto, Andros T Gianuca, Lynn Govaert, Frederik Hendrickx, Janet Higuti, Luc Lens, Koen Martens, Hans Matheve, Erik Matthysen, Elena Piano, Rose Sablon, Isa Schön, Karine Van Doninck, Luc De Meester, Hans Van Dyck
Body size is intrinsically linked to metabolic rate and life-history traits, and is a crucial determinant of food webs and community dynamics1,2 . The increased temperatures associated with the urban-heat-island effect result in increased metabolic costs and are expected to drive shifts to smaller body sizes 3 . Urban environments are, however, also characterized by substantial habitat fragmentation 4 , which favours mobile species. Here, using a replicated, spatially nested sampling design across ten animal taxonomic groups, we show that urban communities generally consist of smaller species...
May 23, 2018: Nature
https://www.readbyqxmd.com/read/29743985/andrographolide-ameliorates-liver-fibrosis-in-mice-involvement-of-tlr4-nf-%C3%AE%C2%BA-b-and-tgf-%C3%AE-1-smad2-signaling-pathways
#7
Liteng Lin, Rui Li, Mingyue Cai, Jingjun Huang, Wensou Huang, Yongjian Guo, Liuhong Yang, Guizhi Yang, Tian Lan, Kangshun Zhu
Liver fibrosis is characterized by activated hepatic stellate cells (HSC) and extracellular matrix accumulation. Blocking the activation of HSC and the inflammation response are two major effective therapeutic strategies for liver fibrosis. In addition to the long history of using andrographolide (Andro) for inflammatory disorders, we aimed at elucidating the pharmacological effects and potential mechanism of Andro on liver fibrosis. In this study, liver fibrosis was induced by carbon tetrachloride (CCl4 ) and the mice were intraperitoneally injected with Andro for 6 weeks...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29694508/andrographolide-protects-mouse-astrocytes-against-hypoxia-injury-by-promoting-autophagy-and-s100b-expression
#8
Juan Du, Chunyan Zhang, Xueqing Na, Aizhi Li, Qingfeng Zhang, Kezhong Li, Yongbo Ding
Andrographolide (ANDRO) has been studied for its immunomodulation, anti-inflammatory, and neuroprotection effects. Because brain hypoxia is the most common factor of secondary brain injury after traumatic brain injury, we studied the role and possible mechanism of ANDRO in this process using hypoxia-injured astrocytes. Mouse cortical astrocytes C8-D1A (astrocyte type I clone from C57/BL6 strains) were subjected to 3 and 21% of O2 for various times (0-12 h) to establish an astrocyte hypoxia injury model in vitro...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29668964/a-pink-salmon-returns-to-the-river-arno
#9
Andros Tofield
No abstract text is available yet for this article.
April 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29668963/the-esc-publications-committee-meeting
#10
Andros Tofield
No abstract text is available yet for this article.
April 14, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29552170/andrographolide-inhibits-proliferation-and-induces-cell-cycle-arrest-and-apoptosis-in-human-melanoma-cells
#11
Guo Liu, Haihan Chu
Andrographolide (Andro), a natural compound isolated from Andrographis paniculata , has been demonstrated to have anticancer efficacy in several types of tumors. In the present study, the anticancer effects and mechanism of Andro in human malignant melanoma were investigated. Cell viability analysis was performed using an MTT assay and the effect of Andro on the cell cycle and apoptosis of human malignant melanoma cells was determined by flow cytometry. Western blot analysis was performed to evaluate the protein expression levels of human malignant melanoma cells following treatment with Andro...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29506066/cardiovascular-research-institute-basel
#12
Andros Tofield
No abstract text is available yet for this article.
March 1, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29479599/from-a-square-core-to-square-opening-structural-diversity-and-magnetic-properties-of-the-oxo-bridged-cr-iii-nb-v-complexes
#13
Marijana Jurić, Lidija Androš Dubraja, Jasminka Popović, Krešimir Molčanov, Filip Torić, Damir Pajić, Ivor Lončarić
Three heterometallic oxo-bridged compounds, [Cr2 (phen)4 (μ-O)4 Nb2 (C2 O4 )4 ]·2H2 O (1; phen = 1,10-phenanthroline), [Cr2 (terpy)2 (H2 O)2 (μ-O)4 Nb2 (C2 O4 )4 ]·4H2 O (2; terpy = 2,2';6',2''-terpyridine) and [Cr(terpy)(C2 O4 )(H2 O)][Cr2 (terpy)2 (C2 O4 )2 (μ-O)2 Nb(C2 O4 )2 ]·3H2 O (3), have been synthesized using a building block approach and characterized by IR spectroscopy, single-crystal and powder X-ray diffraction, magnetization measurements, and DFT calculations. The molecular structures of 1 and 2, crystallizing in P42 21 2 and P21 /n space groups, respectively, contain a square-shaped {Cr(μ-O)4 Nb} unit, while that of complex salt 3 (P1[combining macron] space group) consists of a mononuclear cation containing CrIII and trinuclear anions in which two CrIII ions are bridged by a -O-NbV -O- fragment...
March 28, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29474604/cardiology-update-london-2017-i
#14
Andros Tofield
No abstract text is available yet for this article.
February 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29464237/magneto-structural-correlations-in-oxalate-bridged-sr-ii-cr-iii-coordination-polymers-structure-magnetization-x-band-and-high-field-esr-studies
#15
L Androš Dubraja, M Jurić, J Popović, D Pajić, Y Krupskaya, V Kataev, B Bűchner, D Žilić
The results of high-field electron spin resonance (HF-ESR) spectroscopy on the title 1D coordination polymers at frequencies up to 415 GHz, supported by X-ray diffraction, thermal, magnetic susceptibility, and X-band (10 GHz) ESR studies, are presented. The heterometallic compounds {SrCr2 (phen)2 (C2 O4 )4 }·H2 O (SrCrPhen) and {SrCr2 (bpy)2 (C2 O4 )4 (H2 O)}·5H2 O (SrCrBpy) (phen = 1,10-phenanthroline, bpy = 2,2'-bipyridine) were synthesized. Structural analysis revealed double oxalate-bridged zigzag Sr-Cr chains while magnetic susceptibility studies showed paramagnetic behaviour of the complexes...
March 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29437857/h2afx-and-mdc1-promote-maintenance-of-genomic-integrity-in-male-germ-cells
#16
Erika Testa, Daniela Nardozi, Cristina Antinozzi, Monica Faieta, Stefano Di Cecca, Cinzia Caggiano, Tomoyuki Fukuda, Elena Bonanno, Lou Zhenkun, Andros Maldonado, Ignasi Roig, Monica Di Giacomo, Marco Barchi
In somatic cells, H2afx and Mdc1 are close functional partners in DNA repair and damage response. However, it is not known whether they are also involved in the maintenance of genome integrity in meiosis. By analyzing chromosome dynamics in H2afx-/- spermatocytes, we found that the synapsis of autosomes and X-Y chromosomes was impaired in a fraction of cells. Such defects correlated with an abnormal recombination profile. Conversely, Mdc1 was dispensable for the synapsis of the autosomes and played only a minor role in X-Y synapsis, compared with the action of H2afx This suggested that those genes have non-overlapping functions in chromosome synapsis...
March 20, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29385888/andrographolide-relieved-pathological-pain-generated-by-spared-nerve-injury-model-in-mice
#17
Huang-Chi Wang, Hsin-Sheng Tsay, Hui-Nung Shih, Yi-An Chen, Kai-Ming Chang, Dinesh Chandra Agrawal, Siendong Huang, Yi-Lo Lin, Meng-Jen Lee
CONTEXT: Andrographolide (Andro), found in large quantities in Andrographis paniculata Nees (Acanthaceae), is anti-inflammatory, especially in the central nervous system (CNS) glia. OBJECTIVE: The objective of this study is to test Andro's ability to reduce allodynia in a spared nerve injury model. MATERIAL AND METHODS: Male 30 g BalbC mice were divided into four groups: (1) Sham-operated control (Sham-group); (2) nerve injured and treated with saline (Saline-group); (3) nerve injured and treated with Andro (Andro-group); (4) nerve injured and treated with non-steroidal anti-inflammatory drugs (NSAIDS) (NSAIDS-group)...
December 2018: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29355602/natural-product-andrographolide-alleviated-apap-induced-liver-fibrosis-by-activating-nrf2-antioxidant-pathway
#18
Hongyu Yan, Zhenlin Huang, Qingyun Bai, Yuchen Sheng, Zhanxia Hao, Zhengtao Wang, Lili Ji
As a well-known analgesic drug, acetaminophen (APAP) is commonly used to relieve pain for patients with chronic painful diseases. Our previous study has shown that long-term ingestion of APAP caused liver fibrosis in mice. This study further investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2) in regulating APAP-induced liver fibrosis in mice and the anti-fibrotic effect of natural compound andrographolide (Andro). Our results showed that hepatic collagen deposition and hepatic stellate cells (HSCs) activation induced by APAP were more serious in Nrf2 knock-out mice than in normal wild-type mice...
March 1, 2018: Toxicology
https://www.readbyqxmd.com/read/29335149/-learning-to-separate-together-the-separation-individuation-group
#19
Gwénäelle Andro
The 'separation-individuation' group is offered to children aged between three and five, in outpatient consultations with a paediatric psychiatrist. It was created following the testimonies of early childhood professionals describing the feeling on the part of parents of being torn from their child, during the first year of school. Open and held on a weekly basis, it is combined with a parents' meeting organised simultaneously. The individualised group tool supports the separation-individuation process when this is particularly painful, for the child and the parents...
January 2018: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/29303236/andro-ivf-a-novel-protocol-for-poor-responders-to-ivf-controlled-ovarian-stimulation
#20
Ludmila Bercaire, Sara Mb Nogueira, Priscila Cm Lima, Vanessa R Alves, Nilka Donadio, Artur Dzik, Mario Cavagna
OBJECTIVE: This study aimed to assess a novel protocol designed to improve poor ovarian response through intra-ovarian androgenization. The endpoints were: number of oocytes and mature oocytes retrieved, fertilization, cancellation and pregnancy rates. METHODS: This prospective crossover study enrolled poor responders from previous ovarian stimulation cycles submitted to a novel protocol called ANDRO-IVF. The protocol included pretreatment with transdermal AndroGel(r) (Besins) 25 mg, oral letrozole 2...
March 1, 2018: JBRA Assisted Reproduction
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