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https://www.readbyqxmd.com/read/28327187/schistosomiasis-is-more-prevalent-than-previously-thought-what-does-it-mean-for-public-health-goals-policies-strategies-guidelines-and-intervention-programs
#1
REVIEW
Daniel G Colley, Tamara S Andros, Carl H Campbell
Mapping and diagnosis of infections by the three major schistosome species (Schistosoma haematobium, S. mansoni and S. japonicum) has been done with assays that are known to be specific but increasingly insensitive as prevalence declines or in areas with already low prevalence of infection. This becomes a true challenge to achieving the goal of elimination of schistosomiasis because the multiplicative portion of the life-cycle of schistosomes, in the snail vector, favors continued transmission as long as even a few people maintain low numbers of worms that pass eggs in their excreta...
March 22, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28325227/an-incidentaloma-in-the-cardiology-clinic
#2
Danesh K Kella, Rupak Desai, Leon Rubinsztein, Jeranfel Hernandez, Andro Kacharava
No abstract text is available yet for this article.
April 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28315464/a-novel-nanosuspension-of-andrographolide-preparation-characterization-and-passive-liver-target-evaluation-in-rats
#3
Ligang Guo, Le Kang, Xinrong Liu, Xiangyun Lin, Donghua Di, Yong Wu, Dexian Kong, Yihui Deng, Yanzhi Song
Andrographolide (Andro) is an excellent anti-inflammatory bicyclic diterpene γ-lactone. However, the poor solubility limits its application as injection for the treatment of acute inflammation. To meet the clinical needs for emergency, the Andro nanosuspensions injection was first prepared by the wet milling technique. The Andro nanosuspensions were composed of 3% Andro, 5% poloxamer 188 as the non-ionic stabilizer, 0.05% sodium deoxycholate or 0.1% sodium tauroursodeoxy cholate as the ionic stabilizer, and prepared by 350rpm speed and 12cycles of grinding with 0...
March 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28212886/primary-ameloblastoma-of-the-temporal-bone
#4
Andro Košec, Jakov Ajduk, Mihael Ries, Robert Trotić
Ameloblastoma is a locally aggressive tumor derived from odontogenic epithelium. Although benign, its clinical behavior can often exhibit malignant characteristics. It is marked by slow and persistent growth with infiltration of adjacent tissues. Almost 70% occur in the mandible in patients older than 30 years. Recurrence of ameloblastoma from inadequate treatment is frequent. Because of its slow growth, recurrences can present decades after primary surgery. A primary ameloblastoma in an area outside the mandibular, maxillary, and infratemporal fossa regions has not been described in detail to date, with only 1 possible case mentioned in the literature...
January 24, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28199632/people-s-corner-tiny-jaarsma-phdthe-2016-american-heart-association-distinguished-scientist-award
#5
Andros Tofield
No abstract text is available yet for this article.
February 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28199630/end-of-the-road-for-aliskiren-in-heart-failure
#6
Andros Tofield
No abstract text is available yet for this article.
February 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28193824/correction-to-eco-evolutionary-dynamics-in-urbanized-landscapes-evolution-species-sorting-and-the-change-in-zooplankton-body-size-along-urbanization-gradients
#7
Kristien I Brans, Lynn Govaert, Jessie M T Engelen, Andros T Gianuca, Caroline Souffreau, Luc De Meester
No abstract text is available yet for this article.
April 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28182713/taxifolin-synergizes-andrographolide-induced-cell-death-by-attenuation-of-autophagy-and-augmentation-of-caspase-dependent-and-independent-cell-death-in-hela-cells
#8
Mazen Alzaharna, Iyad Alqouqa, Hon-Yeung Cheung
Andrographolide (Andro) has emerged recently as a potential and effective anticancer agent with induction of apoptosis in some cancer cell lines while induction of G2/M arrest with weak apoptosis in others. Few studies have proved that Andro is also effective in combination therapy. The flavonoid Taxifolin (Taxi) has showed anti-oxidant and antiproliferative effects against different cancer cells. Therefore, the present study investigated the cytotoxic effects of Andro alone or in combination with Taxi on HeLa cells...
2017: PloS One
https://www.readbyqxmd.com/read/28164514/testosterone-measured-with-an-automatic-immunoassay-compares-reasonably-well-to-results-obtained-by-lc-ms-ms
#9
Cindy S Knudsen, Carsten S Hoejskov, Holger J Moller, Ebba Nexo
BACKGROUND: Previous studies have reported problems measuring testosterone with immunological assays. Here we explore an automatic second generation immunoassay compared to a LC-MS/MS method. METHODS: We collected blood samples from 76 women and measured testosterone, progesterone, gender hormonebinding globulin (SHBG), and albumin employing Cobas e601/c501. Testosterone, androstenedione (andro), dehydroepiandrosterone sulphate (DHEAS), and 17-hydroxyprogesterone (17-OHP) concentrations were measured employing LC-MS/MS...
October 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28116742/evaluation-of-ros-tac-score-and-dna-damage-in-fertile-normozoospermic-and-infertile-asthenozoospermic-males
#10
Akram Vatannejad, Heidar Tavilani, Mohammad Reza Sadeghi, Saeid Amanpour, Somyeh Shapourizadeh, Mahmood Doosti
PURPOSE: The aim of study was to evaluate reactive oxygen species (ROS), total antioxidant capacity (TAC) andROS-TAC score as indicator for oxidative stress status as well as 8-hydrodeoxyguanosine (8-OHdG) levels as amarker for DNA damage in the seminal plasma of asthenozoospermia patients compared to normozoospermiasamples. MATERIALS AND METHODS: The semen samples of 28 fertile normozoospermic donors and 25 infertile men withasthenozoospermia were analyzed according to World Health Organization (WHO) criteria...
January 18, 2017: Urology Journal
https://www.readbyqxmd.com/read/28110305/christina-fanola-md-msc
#11
Andros Tofield
No abstract text is available yet for this article.
January 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28097636/andrographolide-antibacterial-activity-against-common-bacteria-of-human-health-concern-and-possible-mechanism-of-action
#12
Malabika Banerjee, Debaprasad Parai, Subrata Chattopadhyay, Samir Kumar Mukherjee
Increasing bacterial resistance to common drugs is a major public health concern for the treatment of infectious diseases. Certain naturally occurring compounds of plant sources have long been reported to possess potential antimicrobial activity. This study was aimed to investigate the antibacterial activity and possible mechanism of action of andrographolide (Andro), a diterpenoid lactone from a traditional medicinal herb Andrographis paniculata. Extent of antibacterial action was assessed by minimal bactericidal concentration method...
January 17, 2017: Folia Microbiologica
https://www.readbyqxmd.com/read/27920375/eco-evolutionary-dynamics-in-urbanized-landscapes-evolution-species-sorting-and-the-change-in-zooplankton-body-size-along-urbanization-gradients
#13
Kristien I Brans, Lynn Govaert, Jessie M T Engelen, Andros T Gianuca, Caroline Souffreau, Luc De Meester
Urbanization causes both changes in community composition and evolutionary responses, but most studies focus on these responses in isolation. We performed an integrated analysis assessing the relative contribution of intra- and interspecific trait turnover to the observed change in zooplankton community body size in 83 cladoceran communities along urbanization gradients quantified at seven spatial scales (50-3200 m radii). We also performed a quantitative genetic analysis on 12 Daphnia magna populations along the same urbanization gradient...
January 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27914228/osteoblastic-extraosseous-osteosarcoma-of-the-neck
#14
Andro Košec, Majda Vučić, Vladimir Bedeković, Mirko Ivkić
Extraosseous osteosarcoma as a primary tumor of the neck is exceedingly rare, with only a few cases reported to date. The most appropriate therapy is still under investigation. We report a case of an aggressive, right-sided, advanced-stage extraosseous osteosarcoma in a female patient. A 48-year-old woman presented with a right-sided infra-parotid mass encompassing neck regions II and III, measuring over 6 cm in craniocaudal diameter. She was initially treated by wide surgical resection. The definitive histopathologic diagnosis was osteoblastic extraosseous osteosarcoma...
March 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27870011/effects-of-dispersal-and-environmental-heterogeneity-on-the-replacement-and-nestedness-components-of-%C3%AE-diversity
#15
Andros T Gianuca, Steven A J Declerck, Pieter Lemmens, Luc De Meester
Traditionally metacommunity studies have quantified the relative importance of dispersal and environmental processes on observed β-diversity. Separating β-diversity into its replacement and nestedness components and linking such patterns to metacommunity drivers can provide richer insights into biodiversity organization across spatial scales. It is often very difficult to measure actual dispersal rates in the field and to define the boundaries of natural metacommunities. To overcome those limitations, we revisited an experimental metacommunity dataset to test the independent and interacting effects of environmental heterogeneity and dispersal on each component of β-diversity...
February 2017: Ecology
https://www.readbyqxmd.com/read/27817039/the-carriers-of-the-a-g-g-g-allelic-combination-of-the-c-2039-a-g-and-c-29-g-a-fsh-receptor-polymorphisms-retrieve-the-highest-number-of-oocytes-in-ivf-icsi-cycles
#16
Adolfo Allegra, Angelo Marino, Stefania Raimondo, Antonio Maiorana, Salvatore Gullo, Piero Scaglione, Aldo Volpes, Riccardo Alessandro
PURPOSE: The objective of this study was the elucidation of the possible role of the single-nucleotide polymorphisms (SNP) at position -29 and 2039 of the FSH receptor gene (FSHR) as independent predictive markers of ovarian response. Indeed, the tailoring of reproductive treatments is crucial for both maximizing the success of IVF patients and obtaining a reduction in hypo- or hyper-response rates. METHODS: This prospective, observational study analyzed the association of -29 and 2039 FSHR polymorphisms with the number of retrieved oocytes in 140 patients attending an IVF/ICSI cycle for severe male factors (≤5,000,000 spermatozoa/mL) or tubal factors at the ANDROS Day Surgery Clinic, Palermo, Italy...
February 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27693549/pharmacologic-antagonism-of-dopamine-receptor-d3-attenuates-neurodegeneration-and-motor-impairment-in-a-mouse-model-of-parkinson-s-disease
#17
Daniela Elgueta, María S Aymerich, Francisco Contreras, Andro Montoya, Marta Celorrio, Estefanía Rojo-Bustamante, Eduardo Riquelme, Hugo González, Mónica Vásquez, Rafael Franco, Rodrigo Pacheco
Neuroinflammation involves the activation of glial cells, which is associated to the progression of neurodegeneration in Parkinson's disease. Recently, we and other researchers demonstrated that dopamine receptor D3 (D3R)-deficient mice are completely refractory to neuroinflammation and consequent neurodegeneration associated to the acute intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this study we examined the therapeutic potential and underlying mechanism of a D3R-selective antagonist, PG01037, in mice intoxicated with a chronic regime of administration of MPTP and probenecid (MPTPp)...
February 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27620195/design-and-evaluation-of-novel-solid-self-nanodispersion-delivery-system-for-andrographolide
#18
Junnan Xu, Yueqin Ma, Yuanbiao Xie, Yingchong Chen, Yang Liu, Pengfei Yue, Ming Yang
Poorly water-soluble drugs offer challenges in developing a formulation product with adequate bioavailability. This study took advantage of the features of nanocrystals and direct compression technologies to develop a novel solid self-nanodispersion delivery system for andrographolide (Andro) in order to increase its dissolution rate for enhancing bioavailability. Andro nanosuspensions (Andro-NS) with a particle size of about 500 nm were prepared by homogenization technology and further converted into dried nanocrystal particles (Andro-NP) via spray-drying...
September 12, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27616978/brain-and-serum-androsterone-is-elevated-in-response-to-stress-in-rats-with-mild-traumatic-brain-injury
#19
Richard J Servatius, Christine E Marx, Swamini Sinha, Pelin Avcu, Jason D Kilts, Jennifer C Naylor, Kevin C H Pang
Exposure to lateral fluid percussion (LFP) injury consistent with mild traumatic brain injury (mTBI) persistently attenuates acoustic startle responses (ASRs) in rats. Here, we examined whether the experience of head trauma affects stress reactivity. Male Sprague-Dawley rats were matched for ASRs and randomly assigned to receive mTBI through LFP or experience a sham surgery (SHAM). ASRs were measured post injury days (PIDs) 1, 3, 7, 14, 21, and 28. To assess neurosteroids, rats received a single 2.0 mA, 0.5 s foot shock on PID 34 (S34), PID 35 (S35), on both days (2S), or the experimental context (CON)...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27599453/pro%C3%A2-neurogenic-effects-of-andrographolide-on-rsc96-schwann-cells-in%C3%A2-vitro
#20
Fuben Xu, Huayu Wu, Kun Zhang, Peizhen Lv, Li Zheng, Jinmin Zhao
Nerve regeneration remains a challenge to the treatment of peripheral nerve injury. Andrographolide (Andro) is the main active constituent of Andrographis paniculata, which has been applied in the treatment of several diseases, including inflammation, in ancient China. Andro has been reported to facilitate the reduction of edema and to exert analgesic effects in the treatment of various diseases. These findings suggest that Andro may be considered a promising anti‑inflammatory agent that may suppress destruction and accelerate proliferation of Schwann cells following peripheral nerve injury...
October 2016: Molecular Medicine Reports
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