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https://www.readbyqxmd.com/read/27912970/-dermatologic-complications-of-long-term-hydroxyurea-therapy
#1
Sana Mokni, Nadia Fetoui Ghariani, Amina Aounallah, Neila Fathallah, Lobna Boussofara, Wafa Saidi, Chaker Ben Salem, Badreddine Sriha, Colendane Belajouza, Mohamed Denguezli, Najet Ghariani, Rafiaa Nouira
Hydroxyurea (HU) is an antitumor agent used to treat myeloproliferative syndromes. HU is usually well tolerated but many dermatological complications have been reported during long-term HU therapy. We describe the case of a patient who developed manydermatological side effects of long-term hydroxyurea therapy, in particularly a squamous cell carcinoma and dermatomyosite-like eruption.
November 10, 2016: Thérapie
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#2
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27892584/a-short-history-of-phototherapy-vitamin-d-and-skin-disease
#3
Paul Jarrett, Robert Scragg
The earliest record between sun exposure and skin disease goes back five millennia to the ancient Egyptians. The modern scientific era of medical light therapy and skin diseases started in 1877 when Downs and Blunt reported that exposure to light inhibited fungal growth in test tubes. Continuing research generated a growing medical interest in the potential the effects of light to treat and cure skin diseases considered as parasitic. This culminated in the awarding of the 1903 Nobel Prize in Medicine to Niels Finsen for his pioneering work showing that light could successfully treat cutaneous mycobacterium tuberculosis (lupus vulgaris), a disfiguring disorder common at the time...
November 28, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27890897/pott-s-puffy-tumor-in-an-adult-a-case-report-and-review-of-literature
#4
Satomi Tatsumi, Min Ri, Naoyuki Higashi, Nozomu Wakayama, Shoji Matsune, Mamiko Tosa
Pott's puffy tumor is a subperiosteal abscess of the frontal bone with osteomyelitis which has become rare because of the widespread use of antibiotics. Here, we report a case of Pott's puffy tumor in a 46-year-old man who visited the department of dermatology with painful swelling of the forehead. Despite open drainage and oral antibiotic therapy, the symptoms recurred twice in the following month. Computed tomography revealed a fistula of frontal bone. The eventual diagnosis was Pott's puffy tumor. The patient underwent endoscopic surgery at the department of otorhinolaryngology and achieved a complete recovery...
2016: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/27885973/leprosy-trends-at-a-tertiary-care-hospital-in-mumbai-india-from-2008-to-2015
#5
Thirumugam Muthuvel, Petros Isaakidis, Hemant Deepak Shewade, Lucy Kattuppara, Rajbir Singh, Srinivas Govindarajulu
BACKGROUND: Leprosy remains an important cause of preventable disabilities. After the advent of multidrug therapy, new leprosy cases have come down dramatically. Despite this achievement, India, which contributes 60% of the global leprosy burden, faces some challenges to eliminate the disease, including active transmission in the community and delayed diagnosis of leprosy patients. OBJECTIVES: The objectives of the study were 1) to determine sociodemographic and clinical characteristics of newly diagnosed adults and children (less than 15 years) with leprosy and their trends over time (2008-2015) and 2) to describe the profile of surgical procedures among leprosy patients registered for reconstructive surgeries during 2006-2015...
2016: Global Health Action
https://www.readbyqxmd.com/read/27885523/a-review-of-the-mechanism-of-action-of-lasers-and-photodynamic-therapy-for-onychomycosis
#6
REVIEW
Anil Kumar Bhatta, Uma Keyal, Xiuli Wang, Emese Gellén
Onychomycosis is one of the most common diseases in the field of dermatology. It refers to the fungal infection of the nail plate or nail bed with high incidence in the general population. The available treatment options for onychomycosis have limited use due to side effects, drug interactions, and contraindications, which necessitates the application of an alternative treatment for onychomycosis. In the recent years, lasers and photodynamic therapy (PDT) have been recognized as alternative treatment options...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27882700/effects-of-lapatinib-or-trastuzumab-alone-and-in-combination-in-human-epidermal-growth-factor-receptor-2-positive-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#7
Yong Xin, Wen Wen Guo, Qian Huang, Pei Zhang, Long-Zhen Zhang, Guan Jiang, Ye Tian
This meta-analysis compared the efficiency and safety of lapatinib and trastuzumab, alone or in combination, administered with neoadjuvant chemotherapy in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer. For dichotomous variables, the relative risk ratio (RR) and 95% confidence interval (CI) were used to investigate outcome measures: pathological complete response (pCR), neutropenia, diarrhea, dermatologic toxicity, and congestive heart failure (CHF). Eight randomized controlled trials of 2350 participants (837 receiving lapatinib, 913 trastuzumab, and 555 combination therapy) were selected to compare the efficiency and safety of lapatinib to trastuzumab...
November 23, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#8
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
November 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27876937/clinical-management-of-demodicosis-in-ongole-cattle
#9
B Sudhakara Reddy, S Sivajothi
Demodicosis was diagnosed in a cattle based on dermatological lesions and examination of skin scrapings. The cattle had anaemia, leucocytosis, eosinophilia and neutrophilia. Cattle was treated with strepto penicillin, ivermectin, amitraz along with supportive therapy. After 2 months of therapy clinical cure and regrowth of hair was noticed.
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27874885/patient-reported-outcomes-of-azelaic-acid-foam-15-for-patients-with-papulopustular-rosacea-secondary-efficacy-results-from-a-randomized-controlled-double-blind-phase-3-trial
#10
Stephen Tyring, James A Solomon, Gerald Staedtler, Jason P Lott, Richard Nkulikiyinka, Kaweh Shakery
Patient-reported treatment outcomes are important for evaluating the impact of drug therapies on patient experience. A randomized, double-blind, vehicle-controlled, parallel-group, multicenter, phase 3 study was conducted in 961 participants to assess patient perception of efficacy, utility, and effect on quality of life (QOL) of an azelaic acid (AzA) 15% foam formulation for the treatment of papulopustular rosacea (PPR). Secondary end points included patient-reported global assessment of treatment response, global assessment of tolerability, and opinion on cosmetic acceptability and practicability of product use...
October 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27874216/complementary-and-alternative-therapies-used-by-patients-of-pediatric-dermatology-outpatient-clinics-in-turkey-a-multicenter-study
#11
Burce Can, Hülya Akan, Filiz Topaloglu Demir, Ilkin Zindanci, Filiz Cebeci, Zafer Turkoglu, Mukaddes Kavala
BACKGROUND: The aim of this study was to determine the frequency of complementary and alternative medicine (CAM) methods used in children and adolescents with chronic skin diseases, which methods parents prefer, and to what extent these methods are useful. MATERIAL AND METHODS: This cross-sectional study was conducted between June and November 2014 in patients with chronic skin diseases attending the outpatient pediatric dermatology clinics of three hospitals in Turkey...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27871345/terra-firma-forme-dermatosis-in-singaporean-patients-the-alcohol-wipe-sign
#12
Choon Chiat Oh, Hazel H Oon, See Ket Ng, Shang Ian Tee, Anjali Jhingan, Wei-Sheng Chong
The term terra firma-forme dermatosis arises from the Latin phrase terra firma, meaning dry land (dirt), thus implying dirt-like dermatosis. The authors highlight five cases of patients with terra firma-forme dermatosis presenting to our dermatology center between 2012 and 2013. All patients presented to the dermatologist for persistent reticulated brown patches on the skin. These patients ranged in age from 6 to 22 years. All patients had tried various cleansing soaps and agents but were unable to remove the patches...
2016: Skinmed
https://www.readbyqxmd.com/read/27868472/topical-and-systemic-antifungals-in-dermatology-practice
#13
Murat Durdu, Macit Ilkit, Yalda Tamadon, Ali Tolooe, Haleh Rafati, Seyedmojtaba Seyedmousavi
Dermatophytosis is generally defined as an infection of the hair, nails, or glabrous skin. These infections are caused by the keratinophilic fungi Trichophyton spp., Microsporum spp., and Epidermophyton, which have been recovered from both symptomatic and asymptomatic individuals. Although dermatophytosis is generally not a life-threatening condition, these types of infections are among the most common infections worldwide, and their incidence has continued to increase consistently in recent years. Area covered: This article provides an overview of the general characteristics of dermatophytes, including their taxonomy and epidemiology, as well as the different clinical forms and laboratory diagnostics of dermatophytosis...
November 19, 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/27867727/optical-lens-microneedle-array-for-percutaneous-light-delivery
#14
Moonseok Kim, Jeesoo An, Ki Su Kim, Myunghwan Choi, Matjaž Humar, Sheldon J J Kwok, Tianhong Dai, Seok Hyun Yun
The limited penetration depth of light in skin tissues is a practical bottleneck in dermatologic applications of light-induced therapies, including anti-microbial blue light therapy and photodynamic skin cancer therapy. Here, we demonstrate a novel device, termed optical microneedle array (OMNA), for percutaneous light delivery. A prototype device with a 11 by 11 array of needles at a spacing of 1 mm and a length of 1.6 mm was fabricated by press-molding poly-(lactic acid) (PLA) polymers. The device also incorporates a matched microlens array that focuses the light through the needle tips at specific points to achieve an optimal intensity profile in the tissue...
October 1, 2016: Biomedical Optics Express
https://www.readbyqxmd.com/read/27859683/s2k-guideline-for-treatment-of-cutaneous-lupus-erythematosus
#15
Annegret Kuhn, Elisabeth Aberer, Zsuzsanna Bata-Csörgő, Marzia Caproni, Andreas Dreher, Camille Frances, Regine Gläser, Hans-Wilhelm Klötgen, Aysche Landmann, Branka Marinovic, Filippa Nyberg, Rodica Olteanu, Annamari Ranki, Jacek C Szepietowski, Beatrix Volc-Platzer
Cutaneous lupus erythematosus (CLE) is a rare inflammatory autoimmune disease with heterogeneous subtypes. To date, no therapeutic agents have been licensed specifically for patients with this disease entity and topical and systemic drugs are mostly used "off-label". The aim of the present guideline was to achieve a broad consensus on treatment strategies for patients with CLE by a European subcommittee, guided by the European Dermatology Forum (EDF) and supported by the European Academy of Dermatology and Venereology (EADV)...
November 15, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27859479/diverse-types-of-dermatologic-toxicities-from-immune-checkpoint-blockade-therapy
#16
REVIEW
Jonathan L Curry, Michael T Tetzlaff, Priyadharsini Nagarajan, Carol Drucker, Adi Diab, Sharon R Hymes, Madeleine Duvic, Wen-Jen Hwu, Jennifer A Wargo, Carlos A Torres-Cabala, Ronald P Rapini, Victor G Prieto
Immunomodulatory drugs that leverages host immune mechanisms to destroy tumor cells has been met with great promise in the treatment of cancer. Immunotherapy, targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and the programmed cell death 1 (PD-1) receptor and its ligand (PD-L1) have shown tremendous improvements in the survival of patients with advanced solid tumors. However, the development of dermatologic toxicity (DT) is a consequence to immunotherapy. Review of published reports of the DT to immunotherapy revealed patients receiving anti-CTCLA-4 antibody or anti-PD-1/PD-L1 antibody often develop a DT of any type and grade...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27857838/hyponatraemia-secondary-to-nivolumab-induced-primary-adrenal-failure
#17
Harris Trainer, Paul Hulse, Claire E Higham, Peter Trainer, Paul Lorigan
: Checkpoint inhibitors, such as ipilimumab and pembrolizumab, have transformed the prognosis for patients with advanced malignant melanoma and squamous non-small-cell lung cancer, and their use will only expand as experience is gained in a variety of other malignancies, for instance, renal and lymphoma. As the use of checkpoint inhibitors increases, so too will the incidence of their unique side effects, termed immune-related adverse events (irAEs), which can affect dermatological, gastrointestinal, hepatic, endocrine and other systems...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27857649/la-n%C3%A3-crolyse-%C3%A3-pidermique-toxique
#18
A Mokline, I Rahmani, L Garsallah, S Tlaili, R Hammouda, A A Messadi
Toxic epidermal necrolysis (TEN) or Lyell's syndrome is a potentially life-threatening dermatological disorder, with clinical and histological features characterized by the destruction and detachment of the skin epithelium and mucous membranes. Intensive symptomatic management is crucial: analgesia, daily dressing changes, prevention of infections and symptomatic intensive care measures (hydration, nutrition and oxygen therapy). The aim of our study is to determine epidemiological, clinical and therapeutic characteristics of patients admitted to the intensive burn care unit of Tunis over 9 years, from July 2001 to July 2009...
March 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27855965/prescribing-practices-for-systemic-agents-in-the-treatment-of-severe-pediatric-atopic-dermatitis-in-the-us-and-canada-the-pedra-treat-survey
#19
Christine R Totri, Lawrence F Eichenfield, Kirsty Logan, Laura Proudfoot, Jochen Schmitt, Irene Lara-Corrales, Jeffrey Sugarman, Wynnis Tom, Elaine Siegfried, Kelly Cordoro, Amy S Paller, Carsten Flohr
BACKGROUND: There is a paucity of literature to direct physicians in the prescribing of immunomodulators for patients with severe atopic dermatitis (AD). OBJECTIVE: To survey systemic agent prescribing practices for severe childhood AD among clinicians in the United States and Canada. METHODS: The TREatment of severe Atopic dermatitis in children Taskforce (TREAT), US&CANADA, a project of the Pediatric Dermatology Research Alliance (PeDRA), developed an online multiple-response survey to assess clinical practice, gather demographic information and details of systemic agent selection, and identify barriers to their use in patients with recalcitrant pediatric AD...
November 14, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27845513/the-switching-from-a-biological-therapy-to-another-biologic-agent-in-psoriatic-patients-the-experience-of-psomarche-group
#20
Giulia Ganzetti, Anna Campanati, Alberta Bettacchi, Giuliano Brandozzi, Valerio Brisigotti, Leonardo Bugatti, Ivana Cataldi, Giorgio Filosa, Alfredo Giacchetti, Giuseppe Lemme, Lorenzo Morresi, Massimiliano Nicolini, Valentina Postacchini, Giuseppe Ricotti, Laura Rosa, Marco Simonacci, Annamaria Offidani
BACKGROUND: Switching is a "hot" topic and the main reasons for switching prior biologic agent are for a primary failure, a secondary failure or drug intolerance, patient's dissatisfaction, physician decision. The aim of the study was to assess the optimization of the switching from a biological to another. METHODS: Five Dermatological Units have participated to PsOMarche working group have studied thirty-eight patients affected moderate to severe chronic plaque psoriasis at time 0 (patient recruitment at time of switching from biological therapy to another), 8 weeks (T8), 16 weeks (T16)...
November 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
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