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Excessive Daytime Sleepiness

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https://www.readbyqxmd.com/read/27920540/treatment-cost-of-narcolepsy-with-cataplexy-in-central-europe
#1
Petra Maresova, Michal Novotny, Blanka Klímová, Kamil Kuča
BACKGROUND: Narcolepsy is a lifelong, rare neurological sleep disorder characterized by chronic, excessive attacks of daytime sleepiness. This disease is often extremely incapacitating, interfering with every aspect of life, in work and social settings. OBJECTIVE: The purpose of this study is to specify the treatment costs of patients in Central Europe (Czech Republic), while the attention is mainly paid to the drugs that were fully or partially covered by public health insurance...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27919403/trace-amine-associated-receptor-1-agonists-as-narcolepsy-therapeutics
#2
Sarah W Black, Michael D Schwartz, Tsui-Ming Chen, Marius C Hoener, Thomas S Kilduff
BACKGROUND: Narcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepiness and cataplexy, a loss of muscle tone triggered by emotional stimulation. Current narcolepsy pharmacotherapeutics include controlled substances with abuse potential or drugs with undesirable side effects. As partial agonists at trace amine-associated receptor 1 (TAAR1) promote wakefulness in mice and rats, we evaluated whether TAAR1 agonism had beneficial effects in two mouse models of narcolepsy...
October 18, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27911338/sleepiness-and-sleep-related-breathing-disorders-in-myotonic-dystrophy-and-responses-to-treatment-a-prospective-cohort-study
#3
Sophie D West, Hanns Lochmüller, Joan Hughes, Antonio Atalaia, Chiara Marini-Bettolo, Simon V Baudouin, Kirstie N Anderson
OBJECTIVE: We conducted prospective assessments in people with myotonic dystrophy type 1 (DM1) with daytime sleepiness, provided targeted therapies and assessed response. METHODS: Patients had overnight sleep assessments. Treatment with continuous positive airway pressure (CPAP) for OSA, non-invasive ventilation (NIV) for respiratory failure, modafinil for excessive daytime sleepiness were commenced. RESULTS: 120 people were studied: mean age 46...
November 29, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27909305/j-curve-relation-between-daytime-nap-duration-and-type-2-diabetes-or-metabolic-syndrome-a-dose-response-meta-analysis
#4
Tomohide Yamada, Nobuhiro Shojima, Toshimasa Yamauchi, Takashi Kadowaki
Adequate sleep is important for good health, but it is not always easy to achieve because of social factors. Daytime napping is widely prevalent around the world. We performed a meta-analysis to investigate the association between napping (or excessive daytime sleepiness: EDS) and the risk of type 2 diabetes or metabolic syndrome, and to quantify the potential dose-response relation using cubic spline models. Electronic databases were searched for articles published up to 2016, with 288,883 Asian and Western subjects...
December 2, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905903/immediate-effect-of-cpap-titration-on-perceived-health-related-quality-of-life-a-prospective-observational-study
#5
Serena Iacono Isidoro, Adriana Salvaggio, Anna Lo Bue, Salvatore Romano, Oreste Marrone, Giuseppe Insalaco
BACKGROUND: Perceived Health Related Quality of Life (HRQoL) is impaired in obstructive sleep apnea (OSA). This study examines changes in HRQoL aspects occurring immediately after CPAP titration. Furthermore, we analyzed variations in each gender and in patients undergoing home or laboratory-based CPAP titration pathways. METHODS: Twohundredfive outpatients (151 M) (56.7 ± 10.3 years) were evaluated, before first visit and nocturnal diagnostic examination (T0), and the morning after CPAP titration (T1)...
December 1, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27905361/-heterogeneity-of-excessive-daytime-sleepiness-in-parkinson-s-disease
#6
O V Babkina, M G Poluektov, O S Levin
For the recent years, a special attention is given to the non-motor symptoms of Parkinson's disease, including sleep/wake disorders representing one of the leading symptoms. Daytime sleepiness occurs in 30-55% of patients depending on duration and stage of the disease, leading to severe maladjustment. This symptom seems to be multifactorial by nature and identification of it's causes could have a great importance for the therapy. The main factors of the development of daytime sleepiness in Parkinson's disease and key points of the pathogenesis of «primary» daytime sleepiness are discussed...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27902703/sleep-apnea-sleep-debt-and-daytime-sleepiness-are-independently-associated-with-road-accidents-a-cross-sectional-study-on-truck-drivers
#7
Sergio Garbarino, Paolo Durando, Ottavia Guglielmi, Guglielmo Dini, Francesca Bersi, Stefania Fornarino, Alessandra Toletone, Carlo Chiorri, Nicola Magnavita
BACKGROUND: Recent research has found evidence of an association between motor vehicle accidents (MVAs) or near miss accidents (NMAs), and excessive daytime sleepiness (EDS) or its main medical cause, Obstructive Sleep Apnea (OSA). However, EDS can also be due to non-medical factors, such as sleep debt (SD), which is common among professional truck drivers. On the opposite side, rest breaks and naps are known to protect against accidents. STUDY OBJECTIVES: To investigate the association of OSA, SD, EDS, rest breaks and naps, with the occurrence of MVAs and NMAs in a large sample of truck drivers...
2016: PloS One
https://www.readbyqxmd.com/read/27891431/excessive-daytime-sleepiness-in-schizophrenia-a-naturalistic-clinical-study
#8
Payal Sharma, Reetika Dikshit, Nilesh Shah, Sagar Karia, Avinash De Sousa
INTRODUCTION: Excessive Daytime Sleepiness (EDS) and sleep problems are common in patients with schizophrenia. The symptom of EDS in schizophrenia can be attributed to various causes including neurobiological changes, sleep disorders, medication or as a symptom of schizophrenia itself. EDS as a symptom in schizophrenia has been understudied. AIM: To assess the prevalence of EDS and to the study the same in patients with first episode and chronic schizophrenia. MATERIALS AND METHODS: In this cross-sectional study 100 patients suffering from schizophrenia as per International Classification of Diseases (ICD-10) criteria were evaluated for sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and EDS using the Epworth Sleepiness Scale (ESS)...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27886023/quantifying-the-dynamic-of-osa-brain-using-multifractal-formalism-a-novel-measure-for-sleep-fragmentation
#9
Somayeh Raiesdana
It is thought that the critical brain dynamics in sleep is modulated during frequent periods of wakefulness. This paper utilizes the capacity of EEG based scaling analysis to quantify sleep fragmentation in patients with obstructive sleep apnea. The scale-free (fractal) behavior refers to a state where no characteristic scale dominates the dynamics of the underlying process which is evident as long range correlations in a time series. Here, Multiscaling (multifractal) spectrum is utilized to quantify the disturbed dynamic of an OSA brain with fragmented sleep...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27880055/excessive-daytime-sleepiness-in-asthma-what-are-the-risk-factors
#10
Sandra Andersson Kallin, Eva Lindberg, Johan Nilsson Sommar, Apostolos Bossios, Linda Ekerljung, Andrei Malinovschi, Roelinde Middelveld, Christer Janson
OBJECTIVE: Previous studies have found that excessive daytime sleepiness (EDS) is a more common problem in asthmatic subjects than in the general population. The aim of this study was to investigate whether the prevalence of EDS is increased in asthmatic subjects and, if so, to analyse the occurrence of potential risk factors for EDS in asthmatics. METHODS: Cross-sectional epidemiological study. In 2008, a postal questionnaire was sent out to a random sample of 45,000 individuals aged 16-75 years in four Swedish cities...
November 23, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27872798/factors-affecting-executive-functions-in-obstructive-sleep-apnea-syndrome-and-volumetric-changes-in-the-prefrontal-cortex
#11
Zahide Yılmaz, Nuray Voyvoda, Eda İnan, Pınar Bekdik Şirinocak, Rabia Terzi
PURPOSE: Obstructive sleep apnea syndrome (OSAS) is associated with cognitive changes and executive functions are among the cognitive domains most affected. However, it is not completely understood which of the factor(s) among hypoxemia, repeated arousal, and sleepiness affect the executive functions. This study aims to evaluate the possible relationship between the executive functions and nocturnal parameters, Epworth Sleepiness Scale (ESS) scores, and prefrontal cortex (PFC) volumes...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27871441/daytime-sleepiness-and-nighttime-sleep-quality-across-the-full-spectrum-of-cognitive-presentations-in-essential-tremor
#12
Brittany Rohl, Kathleen Collins, Sarah Morgan, Stephanie Cosentino, Edward D Huey, Elan D Louis
There is increasing evidence that essential tremor (ET) is a complex and heterogeneous disorder with nonmotor features including cognitive deficits and sleep problems. We are unaware of a study that has examined sleep deficits in ET across the full spectrum of cognitive presentations. Cross-sectional (baseline) data on self-reported nighttime sleep dysfunction and excessive daytime sleepiness were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) in 96 ET cases enrolled in a prospective study...
December 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27865988/persistent-and-new-onset-daytime-sleepiness-in-pregnant-women-a-prospective-observational-cohort-study
#13
Shao-Yu Tsai, Pei-Lin Lee, Jou-Wei Lin, Chien-Nan Lee
BACKGROUND: Daytime sleepiness is a frequent complaint in women during pregnancy. It has also been linked to negative obstetric consequences. Although high prevalence of excessive daytime sleepiness throughout pregnancy is well-documented, neither the causes of persistent daytime sleepiness nor new-onset daytime sleepiness during pregnancy have been investigated. Identifying predictive factors may play an important role in the management of daytime sleepiness in pregnant women and improve prenatal care and maternal-fetal outcomes...
November 8, 2016: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/27865546/french-consensus-management-of-patients-with-hypersomnia-which-strategy
#14
R Lopez, I Arnulf, X Drouot, M Lecendreux, Y Dauvilliers
Central hypersomnias principally involves type 1 narcolepsy (NT1), type 2 narcolepsy (NT2) and idiopathic hypersomnia (IH). Despite great progress made in understanding the physiopathology of NT1 with low cerebrospinal fluid hypocretin-1 levels, current treatment remains symptomatic. The same applies to NT2 and IH, for which the physiopathology is still largely unknown. Controlling excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, sleep paralysis and disturbed night-time sleep are key therapeutic targets in NT1...
November 16, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27863901/a-systematic-review-of-the-literature-on-disorders-of-sleep-and-wakefulness-in-parkinson-s-disease-from-2005-to-2015
#15
REVIEW
Lama M Chahine, Amy W Amara, Aleksandar Videnovic
Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders...
August 31, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27857049/sleep-disordered-breathing-and-excessive-daytime-sleepiness-in-patients-with-epilepsy-a-polysomnographic-study
#16
(no author information available yet)
OBJECTIVES: Epilepsy and sleep-disordered breathing (SDB) are relatively common disorders. SDB induces repetitive arousals and sleep fragmentation and may cause symptomatic epileptic seizures or hypoxic encephalopathy. Epileptic seizures change sleep architecture with increase of light sleep and reduction of REM sleep, which may lead to central apneas. The aim of this study was to evaluate the relationship between SDB and daytime sleepiness in patients with epilepsy, who underwent polysomnography (PSG) due to problems with breathing during sleep or due to excessive daytime sleepiness...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27857041/narcolepsy-with-cataplexy-in-a-child-with-charcot-marie-tooth-disease-case-report
#17
(no author information available yet)
We report an 8-year-old boy diagnosed with both CMT1 and narcolepsy, which were not reported simultaneously presenting in one person. The boy presented with a history of increased suddenly falling frequency and excessive daytime sleepiness for 3 months. CMT1 was diagnosed by electrophysiology and genetic testing. Narcolepsy had not been diagnosed until the frequently falling caused by sudden and transient episodes of legs weakness triggered by emotion was found. Multiple sleep latency test showed multiple sleep onset REM periods with reduced sleep latency...
September 18, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/27837445/predictors-of-fatigue-and-poor-sleep-in-adult-survivors-of-childhood-hodgkin-s-lymphoma-a-report-from-the-childhood-cancer-survivor-study
#18
Amanda M Rach, Valerie McLaughlin Crabtree, Tara M Brinkman, Lonnie Zeltzer, Jordan Gilleland Marchak, Deokumar Srivastava, Brooklee Tynes, Jin-Shei Lai, Leslie L Robison, Gregory T Armstrong, Kevin R Krull
PURPOSE: Survivors of pediatric Hodgkin's lymphoma (HL) are at risk for a number of debilitating late effects. Excessive fatigue and poor sleep quality are primary complaints of HL survivors. Understanding the emotional and physical factors that influence fatigue and sleep quality may provide opportunities for intervention to improve health-related quality of life for HL survivors. METHODS: Data from 751 adult survivors of childhood HL who participated in the Childhood Cancer Survivor Study (CCSS) from 2000-2002 were analyzed...
November 12, 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/27837377/the-use-of-an-online-epworth-sleepiness-scale-to-assess-excessive-daytime-sleepiness
#19
Jennifer Boyes, Panagis Drakatos, Ian Jarrold, Judy Smith, Joerg Steier
PURPOSE: Excessive daytime sleepiness is the most common complaint reported in sleep clinics. We hypothesised that utilising modern media to deliver an online Epworth Sleepiness Scale, age- and gender-related differences in subjective daytime sleepiness could be assessed. METHODS: Age, gender and online Epworth Sleepiness Scale (range 0-24 points) of 39,448 subjects were recorded between January 2013 and November 2015. RESULTS: A significant trend, for males but not females, was found between age and Epworth score (p < 0...
November 12, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27829341/increased-risk-of-dementia-in-patients-with-non-apnea-sleep-disorder
#20
Pi-Shan Sung, Chih-Ching Yeh, Liang-Chao Wang, Peir-Haur Hung, Chih-Hsin Muo, Fung-Chang Sung, Chih-Hung Chen, Kuen-Jer Tsai
BACKGROUND: Sleep disorders other than sleep apnea (non-apnea sleep disorder, NSD), esp. insomnia and excessive daytime sleepiness, has been reported to induce higher risk of cognitive decline and dementia in previous longitudinal follow-up studies. However, large-scale nationwide population-based study may further confirm the association between NSD and dementia. METHODS: It was a nationwide population-based retrospective study. We used data from Taiwan's National Health Insurance Research Database (NHIRD) between January 2000 and December 2011...
November 7, 2016: Current Alzheimer Research
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