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https://www.readbyqxmd.com/read/28334836/trypanosoma-brucei-rap1-maintains-telomere-and-subtelomere-integrity-by-suppressing-terra-and-telomeric-rna-dna-hybrids
#1
Vishal Nanavaty, Ranjodh Sandhu, Sanaa E Jehi, Unnati M Pandya, Bibo Li
Trypanosoma brucei causes human African trypanosomiasis and regularly switches its major surface antigen, VSG, thereby evading the host's immune response. VSGs are monoallelically expressed from subtelomeric expression sites (ESs), and VSG switching exploits subtelomere plasticity. However, subtelomere integrity is essential for T. brucei viability. The telomeric transcript, TERRA, was detected in T. brucei previously. We now show that the active ES-adjacent telomere is transcribed. We find that TbRAP1, a telomere protein essential for VSG silencing, suppresses VSG gene conversion-mediated switching...
March 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28323681/predictors-that-a-diagnosis-of-mild-cognitive-impairment-will-remain-stable-3-years-later
#2
Matthew A Clem, Ryan P Holliday, Seema Pandya, Linda S Hynan, Laura H Lacritz, Fu L Woon
BACKGROUND AND OBJECTIVE: In half to two thirds of patients who are diagnosed with mild cognitive impairment (MCI), the diagnosis neither converts to dementia nor reverts to normal cognition; however, little is known about predictors of MCI stability. Our study aimed to identify those predictors. METHODS: We obtained 3-year longitudinal data from the National Alzheimer's Coordinating Center Uniform Data Set for patients with a baseline diagnosis of MCI. To predict MCI stability, we used the patients' baseline data to conduct three logistic regression models: demographics, global function, and neuropsychological performance...
March 2017: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/28317523/presentations-signs-of-activity-and-differential-diagnosis-of-vitiligo
#3
REVIEW
Boon-Kee Goh, Amit G Pandya
Vitiligo has a variety of presentations, including focal, acrofacial, segmental, and generalized forms. Thorough knowledge of these presentations is important to make the correct diagnosis. Signs of activity are important to recognize so that treatment is optimized. Clinical findings of confettilike depigmentation, trichrome and inflammatory vitiligo, and the Koebner phenomenon should alert the clinician that a patient's disease is likely to worsen. These patients may require systemic treatment to stabilize their disease...
April 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28317233/pirfenidone-and-nintedanib-for-pulmonary-fibrosis-in-clinical-practice-tolerability-and-adverse-drug-reactions
#4
Jonathan A Galli, Aloknath Pandya, Michelle Vega-Olivo, Chandra Dass, Huaqing Zhao, Gerard J Criner
BACKGROUND AND OBJECTIVE: The real-world tolerability of pirfenidone and nintedanib in non-clinical trial patients is unknown. Many patients with pulmonary fibrosis have significant medical co-morbidities or baseline characteristics that exclude them from clinical trial participation. METHODS: We conducted a retrospective chart review study on subjects prescribed nintedanib or pirfenidone for pulmonary fibrosis treatment (any aetiology) from September 2014 to February 2016...
March 20, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28301848/predictors-of-reversion-from-mild-cognitive-impairment-to-normal-cognition
#5
Seema Y Pandya, Laura H Lacritz, Myron F Weiner, Martin Deschner, Fu L Woon
BACKGROUND/AIMS: Few studies have examined predictors of reversion from mild cognitive impairment (MCI) to normal cognition. We sought to identify baseline predictors of reversion, using the National Alzheimer's Coordinating Center Uniform Data Set, by comparing MCI individuals who reverted to normal cognition to those who progressed to dementia. METHODS: Participants (n = 1,208) meeting MCI criteria were evaluated at the baseline visit and 3 subsequent annual visits...
March 17, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28296617/vision-loss-after-intravitreal-injection-of-autologous-stem-cells-for-amd
#6
Ajay E Kuriyan, Thomas A Albini, Justin H Townsend, Marianeli Rodriguez, Hemang K Pandya, Robert E Leonard, M Brandon Parrott, Philip J Rosenfeld, Harry W Flynn, Jeffrey L Goldberg
Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation...
March 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28291624/corrigendum-to-contrast-media-use-in-patients-with-chronic-kidney-disease-undergoing-coronary-angiography-a-systematic-review-and-meta-analysis-of-randomized-trials-int-j-cardiol-2017-137-144
#7
Bhavi Pandya, Jean M Chalhoub, Valay Parikh, Sainath Gaddam, Jonathan Spagnola, Suzanne El-Sayegh, Marc Bogin, Ruben Kandov, James Lafferty, Sripal Bangalore
No abstract text is available yet for this article.
March 11, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28291334/rapid-real-time-antimicrobial-susceptibility-testing-with-electrical-sensing-on-plastic-microchips-with-printed-electrodes
#8
Mohammadali Safavieh, Hardik Jeetendra Pandya, Maanasa Venkataraman, Prudhvi Thirumalaraju, Manoj Kumar Kanakasabapathy, Anupriya Singh, Devbalaji Prabhakar, Manjyot Kaur Chug, Hadi Shafiee
Rapid antimicrobial susceptibility testing is important for efficient and timely therapeutic decision making. Due to globally spread bacterial resistance, the efficacy of antibiotics is increasingly being impeded. Conventional antibiotic tests rely on bacterial culture, which is time-consuming and can lead to potentially inappropriate antibiotic prescription and up-front broad range of antibiotic use. There is an urgent need to develop point-of-care platform technologies to rapidly detect pathogens, identify the right antibiotics, and monitor mutations to help adjust therapy...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28290378/two-founders-of-bombay-neurosciences-professor-gajendra-sinh-and-professor-noshir-hormusjee-wadia
#9
Sunil Pandya
No abstract text is available yet for this article.
March 2017: Neurology India
https://www.readbyqxmd.com/read/28286400/response-to-letter-to-editor-regarding-article-rising-from-plagiarising-maos-d-14-00100r1
#10
Muralee Mohan, Deepthi Shetty, Tripthi Shetty, Kalpa Pandya
No abstract text is available yet for this article.
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28279137/spirituality-happiness-and-psychological-well-being-in-13-to-15-year-olds-a-cross-country-longitudinal-rct-study
#11
Samta P Pandya
Based on a study of 5339 adolescents from 60 schools across 15 countries, this paper reports on the effect of spirituality on their happiness and psychological well-being. A customized spiritual program was administered and post-treatment outcome variable scores of the experimental group were higher. Adolescents from relatively affluent nations, boys, Christians, and those who self-practiced scored higher post-test. This makes a case for nominating spirituality as an important developmental variable for 13- to 15-year olds...
March 2017: Journal of Pastoral Care & Counseling: JPCC
https://www.readbyqxmd.com/read/28267705/ex-utero-intrapartum-treatment-exit-for-upper-airway-obstruction
#12
Colin R Butler, Elizabeth F Maughan, Pranav Pandya, Richard Hewitt
PURPOSE OF REVIEW: Improvements in the antenatal diagnosis of congenital malformations have led to increased detection of fetal airway obstructing lesions, and pediatric ear, nose, and throat surgeons are increasingly involved in these cases. RECENT FINDINGS: This article outlines the typical range of pathology seen, the logistics in providing support for anticipated deliveries and the multidisciplinary management of complex airway cases. SUMMARY: Traditionally, difficulty in obtaining a patent airway at delivery was a major factor in the dismal prognosis of these pregnancies...
April 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28260585/comparison-of-culture-dependent-and-culture-independent-molecular-methods-for-characterization-of-vaginal-microflora
#13
COMPARATIVE STUDY
Shirali Pandya, Kavitha Ravi, Vijaya Srinivas, Smitha Jadhav, Anisa Khan, Anjali Arun, Lee W Riley, Purnima Madhivanan
PURPOSE: To date, molecular methods that circumvent the limitations of traditional culture methods have not been used to describe the vaginal microflora in India. Here, we compared culture and culture-independent molecular methods in characterizing the vaginal microbiota in Indian women. METHODOLOGY: Culture methods involved traditional cultivation on Rogosa and sheep blood agar, whereas culture-independent methods bypassed a culturing step by performing broadrange 16S rDNA PCR on DNA isolated directly from vaginal swabs...
March 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28255676/human-orbital-and-anterior-medial-prefrontal-cortex-intrinsic-connectivity-parcellation-and-functional-organization
#14
Zoe Samara, Elisabeth A T Evers, Alexandros Goulas, Harry B M Uylings, Grazyna Rajkowska, Johannes G Ramaekers, Peter Stiers
The orbital and medial prefrontal cortex (OMPFC) has been implicated in decision-making, reward and emotion processing, and psychopathology, such as depression and obsessive-compulsive disorder. Human and monkey anatomical studies indicate the presence of various cortical subdivisions and suggest that these are organized in two extended networks, a medial and an orbital one. Attempts have been made to replicate these neuroanatomical findings in vivo using MRI techniques for imaging connectivity. These revealed several consistencies, but also many inconsistencies between reported results...
March 2, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28253233/differentiation-of-human-and-murine-induced-pluripotent-stem-cells-to-microglia-like-cells
#15
Hetal Pandya, Michael J Shen, David M Ichikawa, Andrea B Sedlock, Yong Choi, Kory R Johnson, Gloria Kim, Mason A Brown, Abdel G Elkahloun, Dragan Maric, Colin L Sweeney, Selamawit Gossa, Harry L Malech, Dorian B McGavern, John K Park
Microglia are resident inflammatory cells of the CNS and have important roles in development, homeostasis and a variety of neurologic and psychiatric diseases. Difficulties in procuring human microglia have limited their study and hampered the clinical translation of microglia-based treatments shown to be effective in animal disease models. Here we report the differentiation of human induced pluripotent stem cells (iPSC) into microglia-like cells by exposure to defined factors and co-culture with astrocytes...
March 2, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28247184/bayesian-methods-for-calibrating-health-policy-models-a-tutorial
#16
Nicolas A Menzies, Djøra I Soeteman, Ankur Pandya, Jane J Kim
Mathematical simulation models are commonly used to inform health policy decisions. These health policy models represent the social and biological mechanisms that determine health and economic outcomes, combine multiple sources of evidence about how policy alternatives will impact those outcomes, and synthesize outcomes into summary measures salient for the policy decision. Calibrating these health policy models to fit empirical data can provide face validity and improve the quality of model predictions. Bayesian methods provide powerful tools for model calibration...
February 28, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28218428/discoloured-saggy-skin-in-a-57-year-old-woman
#17
C Hayes, E Arkoumani, D Pandya, R Verdolini
No abstract text is available yet for this article.
February 20, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28216034/the-vitiligo-working-group-recommendations-for-narrowband-ultraviolet-b-light-phototherapy-treatment-of-vitiligo
#18
Tasneem F Mohammad, Mohammed Al-Jamal, Iltefat H Hamzavi, John E Harris, Giovanni Leone, Raúl Cabrera, Henry W Lim, Amit G Pandya, Samia M Esmat
BACKGROUND: Treatment of vitiligo with narrowband ultraviolet B light (NBUVB) is an important component of the current standard of care. However, there are no consistent guidelines regarding the dosing and administration of NBUVB in vitiligo, reflected by varied treatment practices around the world. OBJECTIVE: To create phototherapy recommendations to facilitate clinical management and identify areas requiring future research. METHODS: The Vitiligo Working Group (VWG) Phototherapy Committee addressed 19 questions regarding the administration of phototherapy over 3 conference calls...
February 15, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28208671/a-passive-learning-sensor-architecture-for-multimodal-image-labeling-an-application-for-social-robots
#19
Marco A Gutiérrez, Luis J Manso, Harit Pandya, Pedro Núñez
Object detection and classification have countless applications in human-robot interacting systems. It is a necessary skill for autonomous robots that perform tasks in household scenarios. Despite the great advances in deep learning and computer vision, social robots performing non-trivial tasks usually spend most of their time finding and modeling objects. Working in real scenarios means dealing with constant environment changes and relatively low-quality sensor data due to the distance at which objects are often found...
February 11, 2017: Sensors
https://www.readbyqxmd.com/read/28194333/ethics-committees-and-the-changed-clinical-research-environment-in-india-in-2016-a-perspective
#20
Sanish Davis, Poonam Sule, Murtuza Bughediwala, Vrunda Pandya, Shilpi Sinha
INTRODUCTION: Institutional and Independent Ethics Committees (ECs) have as their primary mission the protection of human research subjects. The Central Drugs Standard Control Organization has in the period 2013-2016 introduced several new regulations and amendments to existing regulations overseeing the conduct of Research in India. Several of these have direct effect on the functioning of the EC from a review, approval, and oversight mechanism. METHODOLOGY: The Ethics Council of Indian Society for Clinical Research conducted a questionnaire survey among EC members to understand the impact of these changes in their functioning...
January 2017: Perspectives in Clinical Research
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