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https://www.readbyqxmd.com/read/28511395/clinical-and-cytological-spectrum-of-granulomatous-mastitis-and-utility-of-fnac-in-picking-up-tubercular-mastitis-an-eight-year-study
#1
Divya Achutha Ail, Pallavi Bhayekar, Avinash Joshi, Nidhi Pandya, Anuja Nasare, Pranoti Lengare, Ketan Ashok Narkhede
INTRODUCTION: Granulomatous Mastitis (GM) is a rare, benign, inflammatory disease of the breast. It is a well known mimicker of malignancy, clinically and radiologically. Patients are often subjected to number of tests for the right diagnosis. Non-specific Granulomatous Mastitis (NGM) and Tubercular Mastitis (TBM) are chief among the various causes of GM. They are important to be diagnosed early as their treatment varies significantly. Fine Needle Aspiration Cytology (FNAC) is simple, patient friendly and primary investigation modality in cases of lump in breast...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28495823/how-to-image-the-adult-patient-with-fontan-circulation
#2
REVIEW
Jakob A Hauser, Andrew M Taylor, Bejal Pandya
No abstract text is available yet for this article.
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28492789/single-dose-lignocaine-based-blood-cardioplegia-in-single-valve-replacement-patients
#3
Jaydip Ramani, Amber Malhotra, Vivek Wadhwa, Pranav Sharma, Pankaj Garg, Malkesh Tarsaria, Himani Pandya
OBJECTIVE: Myocardial protection is the most important in cardiac surgery. We compared our modified single-dose long-acting lignocaine-based blood cardioplegia with short-acting St Thomas 1 blood cardioplegia in patients undergoing single valve replacement. METHODS: A total of 110 patients who underwent single (aortic or mitral) valve replacement surgery were enrolled. Patients were divided in two groups based on the cardioplegia solution used. In group 1 (56 patients), long-acting lignocaine based-blood cardioplegia solution was administered as a single dose while in group 2 (54 patients), standard St Thomas IB (short-acting blood-based cardioplegia solution) was administered and repeated every 20 minutes...
March 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28490271/validation-of-a-cardiovascular-disease-policy-micro-simulation-model-using-both-survival-and-receiver-operating-characteristic-curves
#4
Ankur Pandya, Stephen Sy, Sylvia Cho, Sartaj Alam, Milton C Weinstein, Thomas A Gaziano
BACKGROUND: Despite some advances, cardiovascular disease (CVD) remains the leading cause of death and healthcare costs in the United States. We therefore developed a comprehensive CVD policy simulation model that identifies cost-effective approaches for reducing CVD burden. This paper aims to: 1) describe our model in detail; and 2) perform model validation analyses. METHODS: The model simulates 1,000,000 adults (ages 35 to 80 years) using a variety of CVD-related epidemiological data, including previously calibrated Framingham-based risk scores for coronary heart disease and stroke...
May 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28488896/a-sensitive-assay-for-zyan1-in-human-whole-blood-and-urine-utilizing-positive-lc-ms-ms-electrospray-ionization
#5
Harilal Patel, Krunal Soni, Rucha Trivedi, Heather Heading, Jason Geue, Kevinkumar Kansagra, Rahul J Gupta, Vrajesh B Pandya, Nuggehally R Srinivas, Pankaj R Patel, Ranjit C Desai
AIM: A sensitive LC-MS/MS method was developed and validated for estimation of ZYAN1 in human blood/urine. METHODS: An analog internal standard IOX2 along with ZYAN1 was quantified using selective reaction monitoring in positive mode. The chromatographic separation was performed by gradient elution with C18 analytical column (3 µm, 50 mm × 2.0 mm) with 4-min run time using an acidified mobile phase consisting of ammonium formate and acetonitrile. Protein precipitation enabled extraction of analytes from diluted blood/urine...
May 10, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28488672/large-polarization-gradients-and-temperature-stable-responses-in-compositionally-graded-ferroelectrics
#6
Anoop R Damodaran, Shishir Pandya, Yubo Qi, Shang-Lin Hsu, Shi Liu, Christopher Nelson, Arvind Dasgupta, Peter Ercius, Colin Ophus, Liv R Dedon, Josh C Agar, Hongling Lu, Jialan Zhang, Andrew M Minor, Andrew M Rappe, Lane W Martin
A range of modern applications require large and tunable dielectric, piezoelectric or pyroelectric response of ferroelectrics. Such effects are intimately connected to the nature of polarization and how it responds to externally applied stimuli. Ferroelectric susceptibilities are, in general, strongly temperature dependent, diminishing rapidly as one transitions away from the ferroelectric phase transition (TC). In turn, researchers seek new routes to manipulate polarization to simultaneously enhance susceptibilities and broaden operational temperature ranges...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28488600/two-founders-of-bombay-neurosciences-dr-ramchandra-g-ginde-and-dr-menino-de-souza
#7
Sunil Pandya
No abstract text is available yet for this article.
May 2017: Neurology India
https://www.readbyqxmd.com/read/28487882/identification-of-a-novel-rasd1-somatic-mutation-in-a-usp8-mutated-corticotroph-adenoma
#8
Andrew V Uzilov, Khadeen C Cheesman, Marc Y Fink, Leah C Newman, Chetanya Pandya, Yelena Lalazar, Marco Hefti, Mary Fowkes, Gintaras Deikus, Chun Yee Lau, Aye S Moe, Yayoi Kinoshita, Yumi Kasai, Micol Zweig, Arpeta Gupta, Daniela Starcevic, Milind Mahajan, Eric E Schadt, Kalmon D Post, Michael J Donovan, Robert Sebra, Rong Chen, Eliza B Geer
Cushing's disease (CD) is caused by pituitary corticotroph adenomas that secrete excess adrenocorticotropic hormone (ACTH). In these tumors, somatic mutations in the gene USP8 have been identified as recurrent and pathogenic and are the sole known molecular driver for CD. Although other somatic mutations were reported in these studies, their contribution to the pathogenesis of CD remains unexplored. No molecular drivers have been established for a large proportion of CD cases and tumor heterogeneity has not yet been investigated using genomics methods...
May 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28487071/diversity-oriented-sustainable-synthesis-of-antimicrobial-spiropyrrolidine-thiapyrrolizidine-oxindole-derivatives-new-ligands-for-a-metallo-%C3%AE-lactamase-from-klebsiella-pneumonia
#9
Anshu Dandia, Shahnawaz Khan, Pragya Soni, Aayushi Indora, Dinesh Kumar Mahawar, Prateek Pandya, Chetan Singh Chauhan
A simple, environmentally benign and highly proficient microwave assisted one-pot approach for the synthesis of antimicrobial spiropyrrolidine/thiapyrrolizidine oxindole derivatives is reported assembling two pharmacophoric moieties (1,3-indanedione and pyrrolidine/thiapyrrolizidine) in a single molecular framework via three-component 1,3-dipolar cycloaddition reaction of substituted isatin, sarcosine/1,3-thiazoles-4-carboxylic acid and Knoevenagel adduct (2-Cyano-3-phenyl-acrylic acid ethyl ester or 2-Benzylidene-malononitrile) in 2,2,2-trifluoroethanol as a reusable green solvent...
April 27, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28486175/ileocaecal-and-transverse-colonic-tuberculosis-mimicking-colonic-malignancy-a-case-report
#10
Prashant Lakhe, Asma Khalife, Jayashri Pandya
INTRODUCTION: Gastrointestinal tuberculosis is common in the developing world especially in the lower socioeconomic groups. In elderly, it may mimic malignancy. CASE PRESENTATION: A 46-year-old female presented with a 6 month history of diffuse pain in abdomen with low grade fever and loss of weight and appetite. Clinically, differential of malignancy of the large bowel was considered. The computerized tomography(CT) scan of the abdomen revealed a diffuse concentric long segmental thickening of terminal ileum, ileo ceacal junction, ascending colon and narrowing of the transverse colonic end of the splenic flexure suggesting an infective etiology...
April 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28479349/development-of-the-abbott-realtime-zika-assay-for-the-qualitative-detection-of-zika-virus-rna-from-serum-plasma-urine-and-whole-blood-specimens-using-the-m2000-system
#11
Matthew B Frankel, Kinnari Pandya, Jeffrey Gersch, Sarah Siddiqui, George J Schneider
Zika virus is an arthropod-borne flavivirus that has rapidly developed into a world-wide concern. Discovered in 1947, the virus was relatively obscure until an outbreak occurred in 2007 in the Yap islands and spread eventually to the Americas in 2015. Only 20% of patients infected with Zika virus develop symptoms. However, there can be serious consequences of infection including birth defects in developing fetuses and links to Guillain-Barré syndrome. The swift rise in infections has necessitated the development of diagnostic tests for both the detection of viral RNA and the presence of virus-specific antibodies...
May 4, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28471918/reliability-of-radiographic-assessments-of-adolescent-midshaft-clavicle-fractures-by-the-facts-multicenter-study-group
#12
Ying Li, Kyna S Donohue, Christopher B Robbins, Andrew T Pennock, Henry B Ellis, Jeffrey J Nepple, Nirav Pandya, David D Spence, S Clifton Willimon, Benton E Heyworth
OBJECTIVES: There is a recent trend toward increased surgical treatment of displaced midshaft clavicle fractures in adolescents. The primary purpose of this study was to evaluate the intra- and inter-rater reliability of clavicle fracture classification systems and measurements of displacement, shortening, and angulation in adolescents. The secondary purpose was to compare two different measurement methods for fracture shortening. METHODS: This study was performed by a multicenter study group conducting a prospective, comparative, observational cohort study of adolescent clavicle fractures...
April 27, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28455547/associations-of-sleep-disturbance-with-physical-function-and-cognition-in-older-adults-with-cancer
#13
Kah Poh Loh, Chintan Pandya, Jason Zittel, Sindhuja Kadambi, Marie Flannery, Natalie Reizine, Allison Magnuson, Giovanna Braganza, Karen Mustian, William Dale, Paul Duberstein, Supriya Gupta Mohile
PURPOSE: Although sleep disturbances are common in older adults, studies evaluating the prevalence of sleep disturbance and its influence on functional outcomes in older adults with cancer are few. In this study, we examined the prevalence of sleep disturbance and its association with physical function and cognition in older adults with cancer. METHODS: This is a cross-sectional study of patients who were referred and evaluated in the Specialized Oncology Care & Research in the Elderly (SOCARE) clinics at the Universities of Rochester and Chicago from May 2011 to October 2015...
April 28, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28451334/zirconium-tetraazamacrocycle-complexes-display-extraordinary-stability-and-provide-a-new-strategy-for-zirconium-89-based-radiopharmaceutical-development
#14
Darpan N Pandya, Nikunj Bhatt, Hong Yuan, Cynthia S Day, Brandie M Ehrmann, Marcus Wright, Ulrich Bierbach, Thaddeus J Wadas
We report our initial investigations into the use of tetraazamacrocycles as zirconium-89 chelators. We describe the synthesis and complete characterization of several Zr tetraazamacrocycle complexes, and definitively describe the first crystal structure of zirconium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Zr-DOTA) using single crystal X-ray diffraction analysis. After evaluating several radioactive analogs, we found that (89)Zr-DOTA is superior to (89)Zr-DFO, the only (89)Zr-complex to be used clinically in (89)Zr-radiopharmaceutical applications...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28424389/-brodmann-areas-8-and-9-including-the-frontal-eye-field
#15
Masataka Watanabe
Based on cytoarchitectonic analyses, Brodmann assigned numbers 8 and 9 to certain areas of the dorsal and medial prefrontal cortex (PFC) in humans and monkeys. Petrides and Pandya re-analyzed the cytoarchitectures of the human and monkey PFCs, and proposed slightly different brain maps for both species. They assigned numbers 8, 9 and 9/46 to the areas that were originally named areas 8 and 9. Areas 8 and 9 have both lateral and medial regions respectively. The lateral area 8 is important for conditional discrimination learning...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28418614/efficacy-and-safety-of-low-dose-heparin-in-hemodialysis
#16
Mariana Murea, Gregory B Russell, Pirouz Daeihagh, Anita M Saran, Karan Pandya, Mark Cabrera, John M Burkart, Barry I Freedman
INTRODUCTION: The dose of unfractionated heparin (UFH) administered during hemodialysis (HD) varies widely. This prospective study evaluated the safety and efficacy of UFH dose de-escalation. METHODS: Sixty-six prevalent patients on HD receiving UFH per standard-dose protocol (load dose [LD] 50-75 units/kg, maintenance dose [MD] 500-1000 units/hour) had heparin prescription converted to low-dose protocol (start LD 15 units/kg and MD 500 units/hour; dose adjusted in small increments based on assessments of extracorporeal blood circuit)...
April 18, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28415411/quality-by-design-approach-for-an-in-situ-gelling-microemulsion-of-lorazepam-via-intranasal-route
#17
Vidhi Shah, Mukesh Sharma, Radhika Pandya, Rajesh K Parikh, Bhavesh Bharatiya, Atindra Shukla, Hsieh-Chih Tsai
The present study illustrates the application of the concept of Quality by Design for development, optimization and evaluation of Lorazepam loaded microemulsion containing ion responsive In situ gelator gellan gum and carbopol 934. A novel approach involving interactions between surfactant and polymer was employed to achieve controlled drug release and reduced mucociliary clearance. Microemulsion formulated using preliminary solubility study and pseudo ternary phase diagrams showed significantly improved solubilization capacity of Lorazepam with 54...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413271/assist-patient-satisfaction-survey-in-postoperative-pain-management-from-indian-subcontinent
#18
Balavenkata Subramanian, Naman Shastri, Lutful Aziz, Ramachandran Gopinath, Anil Karlekar, Yatin Mehta, Anand Sharma, Jitendra Suhas Bapat, Pradeep Jain, Aveek Jayant, Tanvir Samra, Ajantha Perera, Anil Agarwal, Vijay Shetty, Sushma Bhatnagar, Sunil T Pandya, Paramanand Jain
INTRODUCTION: To compare pain scores at rest and ambulation and to assess patient satisfaction between the different modalities of pain management at different time points after surgery. SETTINGS AND DESIGN: The ASSIST (Patient Satisfaction Survey: Pain Management) was an investigator-initiated, prospective, multicenter survey conducted among 1046 postoperative patients from India. MATERIAL AND METHODS: Pain scores, patient's and caregiver's satisfaction toward postoperative pain treatment, and overall pain management at the hospital were captured at three different time points through a specially designed questionnaire...
January 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28412225/enhancing-tissue-permeability-with-mri-guided-preclinical-focused-ultrasound-system-in-rabbit-muscle-from-normal-tissue-to-vx2-tumor
#19
Yao Sun, Xiaobing Xiong, Darpan Pandya, Youngkyoo Jung, Akiva Mintz, Satoru Hayasaka, Thaddeus J Wadas, King C P Li
High Intensity Focused Ultrasound (HIFU) is an emerging noninvasive, nonionizing physical energy based modality to ablate solid tumors with high power, or increase local permeability in tissues/tumors in pulsed mode with relatively low power. Compared with traditional ablative HIFU, nondestructive pulsed HIFU (pHIFU) is present in the majority of novel applications recently developed for enhancing the delivery of drugs and genes. Previous studies have demonstrated the capability of pHIFU to change tissue local permeability for enhanced drug delivery in both mouse tumors and mouse muscle...
April 12, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28411101/-surgical-management-of-primary-spindle-cell-sarcoma-of-prostate
#20
Keval N Patel, Rohit K Jha, Shashank J Pandya
Primary spindle cell sarcoma of prostate is an extremely rare malignancy and very few cases of it have been reported [1, 2]. We searched literature through Med-Line database using Pub-Med and Scopus for the articles published between January 1988 and September 2016. Our search was limited to the following keywords: "spindle cell sarcoma", "prostate" and "surgical management". Most of the papers focused on histopathology of the tumour; very few were found discussing the surgical management. We here present a case of localized primary spindle cell sarcoma of prostate operated at our institute with the difficulties we faced and their management...
April 11, 2017: Urology
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