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https://www.readbyqxmd.com/read/29138027/imidazo-1-2-a-pyridines-linked-with-thiazoles-thiophene-motif-through-keto-spacer-as-potential-cytotoxic-agents-and-nf-%C3%AE%C2%BAb-inhibitors
#1
Kamala K Vasu, Chander Singh Digwal, Amit N Pandya, Dhaivat H Pandya, Jayesh A Sharma, Sneha Patel, Milee Agarwal
A series of new imidazo[1,2-a]pyridine linked with thiazole/thiophene motif through a keto spacer were synthesized and tested for their cytotoxic potential against three human cancer cell lines including A549, HeLa and U87-MG using MTT assay. Compounds A2, A3, A4, C1 and C2 showed cytotoxicity against all the three cell lines. The selectivity index for compound A4 for A549 and HeLa cells was comparable to that of doxorubicin. Among the synthesized compounds, B5 showed the maximum inhibition of NF-κB activity as ascertained by NF-κB reporter assay (IC50 = 6...
November 11, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29135528/postoperative-harlequin-syndrome-case-report-of-a-rare-but-clinically-striking-condition
#2
Ashley T Kydes, Ashley M Kelley, Samir R Pandya, Samuel M Barst
We present a case of a 2-year-old boy who underwent thoracoscopic resection of a left paraspinal mediastinal mass and developed Harlequin syndrome postoperatively. Harlequin syndrome is a rare neurological condition characterized by unilateral hyperhidrosis and erythema of the head and neck. Our discussion highlights this condition and other differential diagnoses that may present similarly in the postoperative period.
November 9, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29135275/the-effects-of-playing-multiple-high-school-sports-on-national-basketball-association-players-propensity-for-injury-and-athletic-performance
#3
Caitlin Rugg, Adarsh Kadoor, Brian T Feeley, Nirav K Pandya
BACKGROUND: Athletes who specialize in their sport at an early age may be at risk for burnout, overuse injury, and reduced attainment of elite status. Timing of sport specialization has not been studied in elite basketball athletes. HYPOTHESIS: National Basketball Association (NBA) players who played multiple sports during adolescence would be less likely to experience injury and would have higher participation rates in terms of games played and career length compared with single-sport athletes...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29133748/books-from-my-shelf
#4
Sunil Pandya
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29114228/integrative-temporo-spatial-mineralogic-spectroscopic-and-proteomic-analysis-of-postnatal-enamel-development-in-teeth-with-limited-growth
#5
Mirali Pandya, Hui Liu, Smit J Dangaria, Weiying Zhu, Leo L Li, Shuang Pan, Moufida Abufarwa, Roderick G Davis, Stephen Guggenheim, Timothy Keiderling, Xianghong Luan, Thomas G H Diekwisch
Tooth amelogenesis is a complex process beginning with enamel organ cell differentiation and enamel matrix secretion, transitioning through changes in ameloblast polarity, cytoskeletal, and matrix organization, that affects crucial biomineralization events such as mineral nucleation, enamel crystal growth, and enamel prism organization. Here we have harvested the enamel organ including the pliable enamel matrix of postnatal first mandibular mouse molars during the first 8 days of tooth enamel development to conduct a step-wise cross-sectional analysis of the changes in the mineral and protein phase...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29097533/epitaxy-on-polycrystalline-substrates
#6
Shishir Pandya, Lane W Martin
No abstract text is available yet for this article.
November 3, 2017: Science
https://www.readbyqxmd.com/read/29089903/intravesicular-phosphatase-phospho1-function-in-enamel-mineralization-and-prism-formation
#7
Mirali Pandya, Lauren Rosene, Colin Farquharson, José L Millán, Thomas G H Diekwisch
The transport of mineral ions from the enamel organ-associated blood vessels to the developing enamel crystals involves complex cargo packaging and carriage mechanisms across several cell layers, including the ameloblast layer and the stratum intermedium. Previous studies have established PHOSPHO1 as a matrix vesicle membrane-associated phosphatase that interacts with matrix vesicles molecules phosphoethanolamine and phosphocholine to initiate apatite crystal formation inside of matrix vesicles in bone. In the present study, we sought to determine the function of Phospho1 during amelogenesis...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29089900/posttranslational-amelogenin-processing-and-changes-in-matrix-assembly-during-enamel-development
#8
Mirali Pandya, Tiffani Lin, Leo Li, Michael J Allen, Tianquan Jin, Xianghong Luan, Thomas G H Diekwisch
The extracellular tooth enamel matrix is a unique, protein-rich environment that provides the structural basis for the growth of long and parallel oriented enamel crystals. Here we have conducted a series of in vivo and in vitro studies to characterize the changes in matrix shape and organization that take place during the transition from ameloblast intravesicular matrices to extracellular subunit compartments and pericrystalline sheath proteins, and correlated these changes with stages of amelogenin matrix protein posttranslational processing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29084332/assessment-of-neurotrophins-and-inflammatory-mediators-in-vitreous-of-patients-with-diabetic-retinopathy
#9
Joseph D Boss, Pawan Kumar Singh, Hemang K Pandya, Joaquin Tosi, Chaesik Kim, Asheesh Tewari, Mark S Juzych, Gary W Abrams, Ashok Kumar
Purpose: To assess vitreous levels of inflammatory cytokines and neurotrophins (NTs) in diabetic retinopathy (DR) and elucidate their potential roles. Methods: A prospective study was performed on 50 vitreous samples obtained from patients with DR (n = 22) and the nondiabetic controls (n = 28). All patients were candidates for vitrectomy. Inflammatory cytokine and NT levels were determined with ELISA. Potential source and role of NTs was determined by using human retinal Müller glia and mouse photoreceptor cells and challenging them with TNF-α or IL-1β, followed by detection of NTs and cell death...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29076159/lichen-planus-pigmentosus-and-its-variants-review-and-update
#10
REVIEW
Juan Carlos Robles-Méndez, Paulina Rizo-Frías, Maira Elizabeth Herz-Ruelas, Amit G Pandya, Jorge Ocampo Candiani
Lichen planus pigmentosus (LPP) is considered a rare variant of lichen planus (LP). It is characterized by acquired dark brown to gray macular pigmentation located on sun-exposed areas of the face, neck, and flexures, commonly found in dark-skinned patients. In patients with LPP, an inflammatory lichenoid response results in marked pigmentary incontinence. It has been associated with hepatitis C virus, sun exposure, and contactants such as mustard oil and nickel. LPP-inversus affects fair and dark skin, predominantly involving flexural and intertriginous areas, while sun-exposed areas are spared; friction is an associated trigger...
October 26, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29072510/ameliorative-effects-of-curcumin-towards-cyclosporine-induced-genotoxic-potential-an-in-vitro-and-in-silico-study
#11
Ankita J Shah, Sivakumar Prasanth Kumar, Mandava V Rao, Himanshu A Pandya
Several studies documented the ameliorative effects of curcumin which plays a pivotal role in radical scavenging activities. It also participates in various cellular pathways and interacts with multiple targets. In the present study, we investigated the ameliorative effect of curcumin upon chromosomal genotoxicity induced by cyclosporine, an immunosuppressant, using in vitro approaches. A plausible mechanism of how curcumin mitigates the genotoxic implications of cyclosporine was ascertained using in silico tools...
October 26, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29065514/the-role-of-mdm2-in-promoting-genome-stability-versus-instability
#12
REVIEW
M Reza Saadatzadeh, Adily N Elmi, Pankita H Pandya, Khadijeh Bijangi-Vishehsaraei, Jixin Ding, Christopher W Stamatkin, Aaron A Cohen-Gadol, Karen E Pollok
In cancer, the mouse double minute 2 (MDM2) is an oncoprotein that contributes to the promotion of cell growth, survival, invasion, and therapeutic resistance. The impact of MDM2 on cell survival versus cell death is complex and dependent on levels of MDM2 isoforms, p53 status, and cellular context. Extensive investigations have demonstrated that MDM2 protein-protein interactions with p53 and other p53 family members (p63 and p73) block their ability to function as transcription factors that regulate cell growth and survival...
October 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29062531/a-framework-for-public-involvement-at-the-design-stage-of-nhs-health-and-social-care-research-time-to-develop-ethically-conscious-standards
#13
EDITORIAL
Raksha Pandya-Wood, Duncan S Barron, Jim Elliott
PLAIN ENGLISH SUMMARY: Researchers who conduct studies in health and social care are encouraged to involve the public as early as possible in the process of designing their studies. Before their studies are allowed to start researchers must seek approval from a Research Ethics Committee, which will assess whether the study is going to be safe and ethical for patients or healthy volunteers to take part in. The process of ethical review does not consider how researchers work with patients and the public early on to design their studies...
2017: Res Involv Engagem
https://www.readbyqxmd.com/read/29035980/incidence-of-symptomatic-pulmonary-embolus-and-deep-vein-thrombosis-after-knee-arthroscopy-in-the-pediatric-and-adolescent-population
#14
Brian C Lau, Jason Jagodzinski, Nirav K Pandya
OBJECTIVE: The incidence of deep venous thrombosis (DVT) and pulmonary embolism (PE) after pediatric knee arthroscopy is unknown. The purpose of this study was to determine the incidence of venous thromboembolism (VTE) after knee arthroscopy in the pediatric and adolescent population in a high-volume center. DESIGN: Retrospective cohort study. SETTING: Tertiary care children's hospital. PATIENTS: All patients who underwent arthroscopy of the knee for a sports-related injury by 2 surgeons were reviewed...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29020564/can-bioethics-journals-become-role-models-in-making-information-data-opinion-and-cross-cultural-discussions-universally-available
#15
Sunil K Pandya
No abstract text is available yet for this article.
October 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28987494/randomized-placebo-controlled-double-blind-study-of-oral-tranexamic-acid-in-the-treatment-of-moderate-to-severe-melasma
#16
Eunice Del Rosario, Stephanie Florez-Pollack, Lucio Zapata, Katia Hernandez, Andrea Tovar-Garza, Michelle Rodrigues, Linda S Hynan, Amit G Pandya
BACKGROUND: Melasma is a common pigmentary disorder that is often difficult to treat. Tranexamic acid (TA) has emerged as a promising treatment for melasma; however, few controlled studies exist. OBJECTIVE: To determine the efficacy of oral TA in patients with moderate to severe melasma METHODS: Patients with moderate to severe melasma were treated with 250 mg of TA or placebo capsules twice daily for 3 months and sunscreen followed by 3 months of treatment with sunscreen only...
October 4, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28983131/a-simple-and-efficient-approach-for-the-synthesis-of-2-aminated-quinazoline-derivatives-via-metal-free-oxidative-annulation
#17
Amit N Pandya, Eric M Villa, E Jeffrey North
A simple and efficient approach for the synthesis of 2-aminoquinazoline derivatives in moderate to good yields. This reaction employs mild reaction conditions, is metal-free and utilizes readily available starting materials making it a more viable reaction for the scale up synthesis and ligand diversity. Notably, this methodology allows the synthesis of 2-aminoquinazolines using a free amine or cyclic amine enabling structural diversity and good atom economy.
March 29, 2017: Tetrahedron Letters
https://www.readbyqxmd.com/read/28980096/isolated-aortic-root-dilation-in-homocystinuria
#18
Massimiliano Lorenzini, Nishan Guha, James E Davison, Alex Pitcher, Bejal Pandya, Helena Kemp, Robin Lachmann, Perry M Elliott, Elaine Murphy
BACKGROUND: Vascular complications in homocystinuria have been known for many years, but there have been no reports to date on involvement of the ascending aorta. METHODS: We conducted a cross-sectional study of patients with homocystinuria, known to a single metabolic centre, and evaluated in 2016 with a transthoracic echocardiogram. Aortic root dilation was defined as Z-score ≥ 2.0 SD, and graded mild (Z-score 2.0-3.0), moderate (Z-score 3.01-4.0) and severe (Z-score > 4...
October 4, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28979076/development-and-optimization-of-dispersible-tablet-of-bacopa-monnieri-with-improved-functionality-for-memory-enhancement
#19
Vaishali Tejas Thakkar, Amol Deshmukh, Lal Hingorani, Payal Juneja, Lalji Baldaniya, Asha Patel, Tosha Pandya, Mukesh Gohel
INTRODUCTION: The Bacopa monnieri is traditional Ayurvedic medicine, and reported for memory-enhancing effects. The Bacoside is poorly soluble, bitter in taste and responsible for the memory enhancement action. Memory enhancer is commonly prescribed for children or elder people. OBJECTIVE: Poor solubility, patient compliance and bitterness were a major driving force to develop taste masked β-cyclodextrin complex and dispersible tablets. MATERIALS AND METHODS: The inclusion complex of Bacopa monnieri and β-cyclodextrin was prepared in different molar ratios of Bacopa monnieri by Co-precipitation method...
July 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28977199/risk-factors-for-delayed-extubation-after-ventricular-septal-defect-closure-a-prospective-observational-study
#20
Divyakant Parmar, Ketav Lakhia, Pankaj Garg, Kartik Patel, Ritesh Shah, Jigar Surti, Jigar Panchal, Himani Pandya
OBJECTIVE: The objective of our study was to determine the feasibility of early extubation and to identify the risk factors for delayed extubation in pediatric patients operated for ventricular septal defect closure. METHODS: A prospective, observational study was carried out at our Institute. This study involved consecutive 135 patients undergoing ventricular septal defect closure. Patients were extubated if feasible within six hours after surgery. Based on duration of extubation, patients were divided two groups: Group 1= extubation time ≤ 6 hours, Group 2= extubation time >6 hours...
July 2017: Brazilian Journal of Cardiovascular Surgery
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