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https://www.readbyqxmd.com/read/28098085/experience-of-a-faculty-development-workshop-in-mentoring-at-an-indian-medical-college
#1
Jagdish R Varma, Anusha Prabhakaran, Suman Singh, Praveen Singh, Jaishree Ganjiwale, Himanshu Pandya
BACKGROUND: Our medical college is running a mentoring programme for undergraduate medical students since 2009. The academic leadership of the college identified the need to change the focus of the programme from mere problem- solving to professional and personal development of mentees. METHODS: A core group of faculty designed and implemented a workshop on mentoring for 28 mentors. The workshop included reflections on the participants' previous experiences about mentoring, discussion on perceptions of mentees about the existing mentoring programme, self-analysis of mentoring skills, overview of the Surrendering, Accepting, Gifting and Extending (SAGE) model and demonstration of effective mentoring skills using role plays and a film...
September 2016: National Medical Journal of India
https://www.readbyqxmd.com/read/28097309/association-of-quality-of-life-and-location-of-lesions-in-patients-with-vitiligo
#2
Stephanie Florez Pollack, Gaoxiang Jia, Lucio Zapata, Clifford Rodgers, Katia Hernandez, Linda S Hynan, Amit G Pandya
No abstract text is available yet for this article.
January 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28087165/radiographic-comparison-of-adolescent-athletes-with-elbow-osteochondritis-dissecans-to-ulnar-collateral-ligament-injuries-and-controls
#3
Brian C Lau, Nirav K Pandya
BACKGROUND: There are excellent data supporting recommendations to prevent elbow injuries (osteochondritis dissecans [OCD] and ulnar collateral ligament [UCL] injuries), such as pitch count and pitch type in baseball, but anatomic risk factors have not been thoroughly examined. This study aimed to evaluate radiographic measurements in adolescents with elbow OCD lesions or UCL injuries and controls. METHODS: We retrospectively identified adolescent patients between 2011 and 2016 with isolated capitellum OCD, UCL tear, or normal elbows based on magnetic resonance imaging...
January 10, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28081369/randomized-controlled-ethanol-cookstove-intervention-and-blood-pressure-in-pregnant-nigerian-women
#4
Donee Alexander, Amanda Northcross, Nathaniel Wilson, Anindita Dutta, Rishi Pandya, Tope Ibigbami, Damilola Adu, John Olamijulo, Oludare Morhason-Bello, Theodore Karrison, Oladosu Ojengbede, Christopher O Olopade
RATIONALE: Hypertension during pregnancy is a leading cause of maternal mortality. Exposure to household air pollution (HAP) elevates blood pressure (BP). OBJECTIVES: Investigate ability of clean cookstove intervention to lower BP during pregnancy. METHODS: A randomized, controlled trial (RCT) was conducted in Nigeria. Pregnant women cooking with kerosene or firewood were randomly assigned to ethanol (n = 162) or control arms (n = 162). BP measurements were taken during 6 antenatal visits...
January 12, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28068786/topical-and-low-dose-intravenous-tranexamic-acid-in-cyanotic-cardiac-surgery
#5
Jigar Patel, Mrugesh Prajapati, Hardik Patel, Hemang Gandhi, Shilpa Deodhar, Himani Pandya
Background Coagulopathy is a major problem in surgery for cyanotic congenital heart disease. Tranexamic acid has been used both topically and systemically and plays a vital role in pediatric cardiac surgery by reducing blood loss and blood product requirement. We aimed to determine the anti-fibrinolytic effectiveness of low-dose systemic or topical tranexamic acid or a combination of both. Methods Seventy-five patients were divided in 3 groups of 25. Group A patients were given tranexamic acid 20 mg kg(-1) intravenously after sternotomy and 20 mg kg(-1) after heparin reversal...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28062681/dialyzer-based-cell-salvage-system-a-superior-alternative-to-conventional-cell-salvage-in-off-pump-coronary-artery-bypass-grafting
#6
Amber Malhotra, Pankaj Garg, Arvind Kumar Bishnoi, Pranav Sharma, Vivek Wadhawa, Komal Shah, Sanjay Patel, Umesh Kumar Ahirwar, Dayesh Rodricks, Himani Pandya
OBJECTIVES: Our goal was to test the hypothesis that the use of a dialyzer-based cell salvage system during off-pump coronary artery bypass grafting (OPCABG) reduces requirements for homologous blood transfusions (HBT) and improves postoperative haemtochemical parameters. METHODS: Data were prospectively collected for 222 patients who had OPCABG using 3 different cell salvage techniques: (1) dialyzer-based cell salvage (DBCS) (n = 75), (2) conventional cell salvage (CCS) (n = 73) and (3) without cell salvage (WCS) (n = 74)...
January 6, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28050433/primary-liver-abscess-with-anterior-abdominal-wall-extension-caused-by-mycobacteriumtuberculosis-complex
#7
Jayashri Sanjay Pandya, Rahul Vilas Kandekar, Ajeet Ramamani Tiwari, Rahul Kadam, Devbrata Radhikamohan Adhikari
Tubercular liver abscess is generally secondary to some other primary foci in the body, most notably pulmonary and gastrointestinal system. To find primary tubercular liver abscess is rare, with prevalence of 0.34% in patients with hepatic tuberculosis. Abscess tracking into abdominal wall from spinal and para spinal tuberculosis is known, however primary liver tuberculosis rupturing into anterior abdominal wall has been reported only twice in literature. We report a case of 43-year-old female with direct invasion of the anterior abdominal wall from an isolated tubercular parenchymal liver abscess, caused by Mycobacterium tuberculosis complex, diagnosed primarily on smear for Acid Fast Bacilli (AFB), imaging and isolated by culture and BACTEC MGIT 960 KIT...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28042744/influence-of-acute-and-chronic-kidney-failure-in-rats-on-the-disposition-and-pharmacokinetics-of-zyan1-a-novel-prolyl-hydroxylase-inhibitor-for-the-treatment-of-chronic-kidney-disease-induced-anemia
#8
Harilal Patel, Amit Arvind Joharapurkar, Vrajesh Bhaskarbhai Pandya, Vishal Jagjivanbhai Patel, Samadhan Govind Kshirsagar, Prakash Patel, Bhavesh Gevriya, Mukul R Jain, Nuggehally R Srinivas, Pankaj Ramanbhai Patel, Ranjit C Desai
1. ZYAN1 is a prolyl hydroxylase inhibitor in clinical development for treatment of anemia associated with chronic kidney disease (CKD). We evaluated the effect of acute and chronic kidney impairment on the pharmacokinetics of ZYAN1 in rat models. 2. Cisplatin (2.5, 5 and 7.5 mg/kg) was used to induce acute kidney injury (AKI), and five-sixth and total nephrectomy was used to induce chronic kidney injury (CKI) in male Wistar rats. All groups received a single 15 mg/kg oral dose of ZYAN1. Blood/urine samples were analyzed for ZYAN1 to assess peak concentration (Cmax), area under the concentration-time curve (AUCinf), total body clearance (CL/F) and elimination half-life (T1/2)...
January 19, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28038833/structure-activity-relationship-of-daptomycin-analogues-with-substitution-at-2s-3r-3-methyl-glutamic-acid-position
#9
Du'an Lin, Hiu Yung Lam, Wenbo Han, Nicole Cotroneo, Bhaumik A Pandya, Xuechen Li
Daptomycin is a highly effective lipopeptide antibiotic against Gram-positive pathogens. The presence of (2S, 3R) 3-methyl glutamic acid (mGlu) in daptomycin has been found to be important to the antibacterial activity. However the role of (2S, 3R) mGlu is yet to be revealed. Herein, we reported the syntheses of three daptomycin analogues with (2S, 3R) mGlu substituted by (2S, 3R) methyl glutamine (mGln), dimethyl glutamic acid and (2S, 3R) ethyl glutamic acid (eGlu), respectively, and their antibacterial activities...
December 18, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28031424/the-dart-study-results-from-the-dose-escalation-and-expansion-cohorts-evaluating-the-combination-of-dalantercept-plus-axitinib-in-advanced-renal-cell-carcinoma
#10
Martin H Voss, Rupal S Bhatt, Elizabeth R Plimack, Brian I Rini, Robert S Alter, J Thaddeus Beck, Dawn Wilson, Xiaosha Zhang, Musa Mutyaba, Chad Glasser, Kenneth M Attie, Matthew L Sherman, Shuchi S Pandya, Michael Atkins
PURPOSE: Activin receptor-like kinase 1 (ALK1) is a novel target in angiogenesis. Concurrent targeting of ALK1 and vascular endothelial growth factor (VEGF) signaling results in augmented inhibition of tumor growth in renal cell carcinoma (RCC) xenograft models. Dalantercept is an ALK1 receptor-fusion protein that acts as a ligand trap for bone morphogenetic proteins (BMP) 9 and 10. The DART Study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept plus axitinib in patients with advanced RCC and determined the optimal dose for further testing...
December 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28017255/cognitive-deficits-in-non-demented-diabetic-elderly-appear-independent-of-brain-amyloidosis
#11
Gloria C Chiang, Eileen Chang, Sneha Pandya, Amy Kuceyeski, James Hu, Richard Isaacson, Christine Ganzer, Aaron Schulman, Vivian Sobel, Shankar Vallabhajosula, Lisa Ravdin
BACKGROUND: To determine the effects of Type 2 diabetes (DM2) on levels of brain amyloidosis and cognition in a community-dwelling cohort of nondemented elderly individuals. METHODS: 33 subjects (16 DM2, 17 nondiabetic) were prospectively recruited. Subjects underwent a PET scan using the amyloid tracer, Pittsburgh Compound B, and a neuropsychological evaluation. Associations between DM2, brain amyloidosis, and cognition were assessed using multivariate regressions, adjusting for age and APOE4 status...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28009216/constraints-on-ultrahigh-energy-cosmic-ray-sources-from-a-search-for-neutrinos-above-10%C3%A2-pev-with-icecube
#12
M G Aartsen, K Abraham, M Ackermann, J Adams, J A Aguilar, M Ahlers, M Ahrens, D Altmann, K Andeen, T Anderson, I Ansseau, G Anton, M Archinger, C Argüelles, J Auffenberg, S Axani, X Bai, S W Barwick, V Baum, R Bay, J J Beatty, J Becker Tjus, K-H Becker, S BenZvi, P Berghaus, D Berley, E Bernardini, A Bernhard, D Z Besson, G Binder, D Bindig, M Bissok, E Blaufuss, S Blot, C Bohm, M Börner, F Bos, D Bose, S Böser, O Botner, J Braun, L Brayeur, H-P Bretz, A Burgman, T Carver, M Casier, E Cheung, D Chirkin, A Christov, K Clark, L Classen, S Coenders, G H Collin, J M Conrad, D F Cowen, R Cross, M Day, J P A M de André, C De Clercq, E Del Pino Rosendo, H Dembinski, S De Ridder, P Desiati, K D de Vries, G de Wasseige, M de With, T DeYoung, J C Díaz-Vélez, V di Lorenzo, H Dujmovic, J P Dumm, M Dunkman, B Eberhardt, T Ehrhardt, B Eichmann, P Eller, S Euler, P A Evenson, S Fahey, A R Fazely, J Feintzeig, J Felde, K Filimonov, C Finley, S Flis, C-C Fösig, A Franckowiak, E Friedman, T Fuchs, T K Gaisser, J Gallagher, L Gerhardt, K Ghorbani, W Giang, L Gladstone, M Glagla, T Glüsenkamp, A Goldschmidt, G Golup, J G Gonzalez, D Grant, Z Griffith, C Haack, A Haj Ismail, A Hallgren, F Halzen, E Hansen, B Hansmann, T Hansmann, K Hanson, D Hebecker, D Heereman, K Helbing, R Hellauer, S Hickford, J Hignight, G C Hill, K D Hoffman, R Hoffmann, K Holzapfel, K Hoshina, F Huang, M Huber, K Hultqvist, S In, A Ishihara, E Jacobi, G S Japaridze, M Jeong, K Jero, B J P Jones, M Jurkovic, A Kappes, T Karg, A Karle, U Katz, M Kauer, A Keivani, J L Kelley, J Kemp, A Kheirandish, M Kim, T Kintscher, J Kiryluk, T Kittler, S R Klein, G Kohnen, R Koirala, H Kolanoski, R Konietz, L Köpke, C Kopper, S Kopper, D J Koskinen, M Kowalski, K Krings, M Kroll, G Krückl, C Krüger, J Kunnen, S Kunwar, N Kurahashi, T Kuwabara, M Labare, J L Lanfranchi, M J Larson, F Lauber, D Lennarz, M Lesiak-Bzdak, M Leuermann, J Leuner, L Lu, J Lünemann, J Madsen, G Maggi, K B M Mahn, S Mancina, M Mandelartz, R Maruyama, K Mase, R Maunu, F McNally, K Meagher, M Medici, M Meier, A Meli, T Menne, G Merino, T Meures, S Miarecki, L Mohrmann, T Montaruli, M Moulai, R Nahnhauer, U Naumann, G Neer, H Niederhausen, S C Nowicki, D R Nygren, A Obertacke Pollmann, A Olivas, A O'Murchadha, T Palczewski, H Pandya, D V Pankova, Ö Penek, J A Pepper, C Pérez de Los Heros, D Pieloth, E Pinat, P B Price, G T Przybylski, M Quinnan, C Raab, L Rädel, M Rameez, K Rawlins, R Reimann, B Relethford, M Relich, E Resconi, W Rhode, M Richman, B Riedel, S Robertson, M Rongen, C Rott, T Ruhe, D Ryckbosch, D Rysewyk, L Sabbatini, S E Sanchez Herrera, A Sandrock, J Sandroos, S Sarkar, K Satalecka, M Schimp, P Schlunder, T Schmidt, S Schoenen, S Schöneberg, L Schumacher, D Seckel, S Seunarine, D Soldin, M Song, G M Spiczak, C Spiering, M Stahlberg, T Stanev, A Stasik, A Steuer, T Stezelberger, R G Stokstad, A Stößl, R Ström, N L Strotjohann, G W Sullivan, M Sutherland, H Taavola, I Taboada, J Tatar, F Tenholt, S Ter-Antonyan, A Terliuk, G Tešić, S Tilav, P A Toale, M N Tobin, S Toscano, D Tosi, M Tselengidou, A Turcati, E Unger, M Usner, J Vandenbroucke, N van Eijndhoven, S Vanheule, M van Rossem, J van Santen, J Veenkamp, M Vehring, M Voge, M Vraeghe, C Walck, A Wallace, M Wallraff, N Wandkowsky, Ch Weaver, M J Weiss, C Wendt, S Westerhoff, B J Whelan, S Wickmann, K Wiebe, C H Wiebusch, L Wille, D R Williams, L Wills, M Wolf, T R Wood, E Woolsey, K Woschnagg, D L Xu, X W Xu, Y Xu, J P Yanez, G Yodh, S Yoshida, M Zoll
We report constraints on the sources of ultrahigh-energy cosmic rays (UHECRs) above 10^{9}  GeV, based on an analysis of seven years of IceCube data. This analysis efficiently selects very high- energy neutrino-induced events which have deposited energies from 5×10^{5}  GeV to above 10^{11}  GeV. Two neutrino-induced events with an estimated deposited energy of (2.6±0.3)×10^{6}  GeV, the highest neutrino energy observed so far, and (7.7±2.0)×10^{5}  GeV were detected. The atmospheric background-only hypothesis of detecting these events is rejected at 3...
December 9, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27995636/managing-the-rising-costs-and-high-drug-expenditures-in-critical-care-pharmacy-practice
#13
Alexander H Flannery, Komal Pandya, Melanie E Laine, Philip J Almeter, Jeremy D Flynn
Pharmaceutical costs for patients in the intensive care unit (ICU) constitute a large portion of hospital drug budgets. Unfortunately, prices for medications commonly used in the ICU are on the rise for a variety of reasons. In particular, the U.S. Food and Drug Administration's Unapproved Drugs Initiative, generic manufacturers cornering the marketplace, drug shortages, and regulatory device changes are major drivers of pharmaceutical price escalation affecting costs in the ICU. Furthermore, traditional high acquisition cost items still pose challenges to controlling costs...
January 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/27987408/label-free-electrical-sensing-of-bacteria-in-eye-wash-samples-a-step-towards-point-of-care-detection-of-pathogens-in-patients-with-infectious-keratitis
#14
Hardik J Pandya, Manoj Kumar Kanakasabapathy, Saloni Verma, Manjyot Kaur Chug, Adnan Memic, Mihaela Gadjeva, Hadi Shafiee
The diagnosis of keratitis is based on visual exam, tissue cytology, and standard microbial culturing to determine the type of the infectious pathogen. To prescribe appropriate therapy, it is important to distinguish between bacterial, fungal, and viral keratitis, as the treatments are quite different. Diagnosis of the causative organism has a substantial prognostic importance. Further, timely knowledge of the nature of the pathogen is also critical to adapt therapy in patients unresponsive to empiric treatment options, which occurs in 10% of all cases...
December 13, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27983477/comparison-of-culture-dependent-and-culture-independent-molecular-methods-for-characterisation-of-vaginal-microflora
#15
Shirali Pandya, Kavitha Ravi, Vijaya Srinivas, Smitha Jadhav, Anisa Khan, Anjali Arun, Lee W Riley, Purnima Madhivanan
To date, molecular methods that circumvent the limitations of traditional culture methods have not been used to describe the vaginal microflora in India. Here, we compared culture and culture-independent molecular methods in characterising the vaginal microbiota in Indian women. Culture methods involved traditional cultivation on Rogosa and sheep-blood agar, whereas culture-independent methods bypassed a culturing step by performing broad-range 16S rDNA PCR on DNA isolated directly from vaginal swabs. A total of 13 women were included in the study, of which five were characterised as healthy, two were BV-intermediate and six were BV-positive according to Nugent scoring...
December 14, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27972481/assessing-the-clinical-and-economic-burden-of-prostate-cancer-in-the-united-states-veteran-population
#16
L Wang, L Li, X Zhou, S Pandya, O Baser
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971387/a-real-world-evaluation-of-the-clinical-and-economic-burden-of-united-states-veteran-patients-with-post-traumatic-stress-disorder
#17
L Wang, L Li, X Zhou, S Pandya, O Baser
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970778/evaluation-of-the-clinical-characteristics-and-economic-burden-of-united-states-veteran-patients-diagnosed-with-the-hepatitis-c-virus
#18
L Wang, L Li, X Zhou, S Pandya, O Baser
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970546/evaluating-socio-demographic-characteristics-of-patients-in-the-united-states-department-of-defense-population
#19
L Wang, L Li, S Pandya, O Baser
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970157/tct-771-clinical-and-hemodynamic-efficacy-of-balloon-pulmonary-angioplasty-for%C3%A2-inoperable-chronic-thromboembolic-pulmonary-hypertension-a%C3%A2-meta-analysis
#20
Arun Kanmanthareddy, Alok Saurav, Hemantha Koduri, JItendra Pandya, Abhilash Akinapelli, Aiman Smer, Muhammad Azzouz, Michael White, Anjali Vaidya, Scott Lilly
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
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