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miRNA liver

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https://www.readbyqxmd.com/read/29777724/novel-mirna-biomarkers-for-genotoxicity-screening-in-mouse
#1
Hiroyuki Oka, Koichi Masuno, Takeki Uehara, Toru Okamoto, Yoshiharu Matsuura, Toru Nakano, Shinpei Yamaguchi
The genotoxic potential of drugs is a serious problem, and its evaluation is one of the most critical processes of drug development. Although the comet assay of compound-exposed tissue is a frequently used genotoxicity test, its high false-positive rate is a major complication, and we consistently obtained false-positive results using the comet assay of mouse liver for nine hepatotoxic non-genotoxins (NGTXs). To identify novel genotoxin (GTX)-specific biomarkers, we screened the expression of 750 microRNAs (miRNAs) in the livers of mice treated with GTXs or NGTXs...
May 16, 2018: Toxicology
https://www.readbyqxmd.com/read/29769539/integrated-analysis-of-hepatic-mrna-and-mirna-profiles-identified-molecular-networks-and-potential-biomarkers-of-nafld
#2
Mingzhe Zhu, Qianlei Wang, Wenjun Zhou, Tao Liu, Lili Yang, Peiyong Zheng, Li Zhang, Guang Ji
To enhance our understanding of molecular mechanisms and mine novel biomarkers of non-alcoholic fatty liver disease (NAFLD), RNA sequencing was performed to gain hepatic expression profiles of mRNAs and miRNAs in NAFLD and normal rats. Using DESeq with thresholds of a two-fold change and a false discovery rate (FDR) less than 0.05, 336 mRNAs and 21 miRNAs were identified as differentially expressed. Among those, 17 miRNAs (e.g., miR-144-3p, miR-99a-3p, miR-200b-3p, miR-200b-5p, miR-200c-3p, etc.) might serve as novel biomarkers of NAFLD...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764990/ire1%C3%AE-prevents-hepatic-steatosis-by-processing-and-promoting-the-degradation-of-select-micrornas
#3
Jie-Mei Wang, Yining Qiu, Zhao Yang, Hyunbae Kim, Qingwen Qian, Qinghua Sun, Chunbin Zhang, Lei Yin, Deyu Fang, Sung Hong Back, Randal J Kaufman, Ling Yang, Kezhong Zhang
Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. An impaired UPR is associated with hepatic steatosis and nonalcoholic fatty liver disease (NAFLD), which is caused by lipid accumulation in the liver. We found that IRE1α was critical to maintaining lipid homeostasis in the liver by repressing the biogenesis of microRNAs (miRNAs) that regulate lipid mobilization...
May 15, 2018: Science Signaling
https://www.readbyqxmd.com/read/29763928/identification-and-verification-of-candidate-genes-regulating-neural-stem-cells-behavior-under-hypoxia
#4
Zhongju Shi, Zhijian Wei, Jiahe Li, Shiyang Yuan, Bin Pan, Fujiang Cao, Hengxing Zhou, Yan Zhang, Yao Wang, Shiwei Sun, Xiaohong Kong, Shiqing Feng
BACKGROUND/AIMS: Neural stem cells (NSCs) reside in a hypoxic environment, and hypoxia plays an important role in their development and differentiation. This study aimed to explore the underlying mechanisms by which hypoxia affects NSC behavior. METHODS: In the current study, we downloaded the gene expression dataset GSE68572 and identified the differentially expressed genes (DEGs) by analyzing high-throughput gene expression in hypoxic and normoxic NSCs. Subsequently, we analyzed these data using a combined bioinformatics approach and predicted the microRNAs (miRNAs) targeting the key gene using miRNA databases...
May 10, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29751497/epigenetic-regulation-of-atp-binding-cassette-protein-a1-abca1-gene-expression-a-new-era-to-alleviate-atherosclerotic-cardiovascular-disease
#5
Mohamed Zaiou, Ahmed Bakillah
The most important function of high density lipoprotein (HDL) is its ability to remove cholesterol from cells and tissues involved in the early stages of atherosclerosis back to the liver for excretion. The ATP-binding cassette transporters ABCA1 and ABCG1 are responsible for the major part of cholesterol efflux to HDL in macrophage foam cells. Thus, promoting the process of reverse cholesterol transport (RCT) by upregulating mainly ABCA1 remains one of the potential targets for the development of new therapeutic agents against atherosclerosis...
May 3, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29751293/the-potential-atheroprotective-role-of-plant-mir156a-as-a-repressor-of-monocyte-recruitment-on-inflamed-human-endothelial-cells
#6
Dongxia Hou, Fangfang He, Lina Ma, Minghui Cao, Zhen Zhou, Zhe Wei, Yunxing Xue, Xiaolin Sang, Hoshun Chong, Congcong Tian, Shasha Zheng, Jing Li, Ke Zen, Xi Chen, Zhi Hong, Chen-Yu Zhang, Xiaohong Jiang
MicroRNAs have become the spotlight of the biological community for more than a decade, but we are only now beginning to understand their functions. The detection of stably expressed endogenous microRNAs in human blood suggests that these circulating miRNAs can mediate intercellular communication. Our previous study reported the surprising finding that exogenous rice MIR168a could regulate liver low-density lipoprotein receptor adapter protein 1 (LDLRAP1) gene expression in mice. Here, we show that plant MIR156a, which is abundantly expressed in dietary green veggies, also stably presents in healthy human serum...
April 8, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29751019/nighttime-light-exposure-enhances-rev-erb%C3%AE-targeting-micrornas-and-contributes-to-hepatic-steatosis
#7
Patricia C Borck, Thiago M Batista, Jean F Vettorazzi, Gabriela M Soares, Camila Lubaczeuski, Dongyin Guan, Antonio C Boschero, Elaine Vieira, Mitchell A Lazar, Everardo M Carneiro
OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbα and up-regulation of its lipogenic targets ACL and FAS in liver...
May 8, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29750148/expression-and-regulation-profile-of-mature-microrna-in-the-pig-relevance-to-xenotransplantation
#8
REVIEW
Zongpei Song, David K C Cooper, Zhiming Cai, Lisha Mou
The pig is an important source of meat production and provides a valuable model for certain human diseases. MicroRNA (miRNA), which is noncoding RNA and regulates gene expression at the posttranscriptional level, plays a critical role in various biological processes. Studies on identification and function of mature miRNAs in multiple pig tissues are increasing, yet the literature is limited. Therefore, we reviewed current research to determine the miRNAs expressed in specific pig tissues that are involved in carcass values (including muscle and adipocytes), reproduction (including pituitary, testis, and ovary), and development of some solid organs (e...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29749537/exosome%C3%A2-encapsulated-microrna%C3%A2-23b-as-a-minimally-invasive-liquid-biomarker-for-the-prediction-of-recurrence-and-prognosis-of-gastric-cancer-patients-in-each-tumor-stage
#9
Yoshimasa Kumata, Hisae Iinuma, Yusuke Suzuki, Daisuke Tsukahara, Hironori Midorikawa, Yuichi Igarashi, Naruyoshi Soeda, Takashi Kiyokawa, Masahiro Horikawa, Ryoji Fukushima
Recently, exosome‑encapsulated microRNAs (miRNAs) have been attracting attention as stable and minimally invasive biomarkers in cancer patients. The aim of the present study was to clarify the value of plasma exosomal microRNA‑23b (miR‑23b) as a diagnostic and prognostic biomarker in gastric cancer (GC) patients at each tumor stage. We first selected recurrence specific exosomal miRNA by miRNA microarray from 6 GC patients (stage I) with or without recurrence, and 3 healthy volunteers. In this analysis, miR‑23b demonstrated the most significant change...
May 8, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29749515/significant-role-of-microrna%C3%A2-219%C3%A2-5p-in-diabetic-retinopathy-and-its-mechanism-of-action
#10
Junying Zhao, Sha Gao, Yanji Zhu, Xi Shen
Diabetic retinopathy (DR) is the leading cause of blindness and visual impairment. The role of microRNA (miRNA) in DR remains largely unknown. The present study aimed to investigate the role of miR‑219‑5p in the progression of DR. Human retinal pigment epithelial (RPE) cells were treated with a high concentration of glucose (50 mM D‑glucose) for 24 h and the miR‑219‑5p level was detected using reverse transcription‑quantitative polymerase chain reaction. The results revealed that miR‑219‑5p was significantly upregulated by high glucose (HG) treatment...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749134/mir-215-enhances-hcv-replication-by-targeting-trim22-and-inactivating-nf-%C3%AE%C2%BAb-signaling
#11
Hui Tian, Zhenkun He
PURPOSE: Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associated with HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCV replication. MATERIALS AND METHODS: The expression levels of miR-215 and TRIM22 were detected by quantitative real-time PCR (qRT-PCR) and western blot analysis in Con1b subgenomic genotype 1b HCV replicon cells (Con1b cells) and JFH1 full genome infecting Huh7...
June 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29748604/microrna-29b-142-5p-contribute-to-the-pathogenesis-of-biliary-atresia-by-regulating-the-ifn-%C3%AE-gene
#12
Yifan Yang, Zhu Jin, Rui Dong, Chao Zheng, Yanlei Huang, Yijie Zheng, Zhen Shen, Gong Chen, Xiaoying Luo, Shan Zheng
Biliary atresia is one of the most common liver disease in infancy. The cause and pathogenesis remain largely unknown. This study aimed to investigate the potential regulatory effect of miR-29b/142-5p on IFN-γ gene methylation. miRNAs microarray was performed on four pairs of liver and blood specimens from biliary atresia and choledochal cysts. We found the overexpression of miR-142-5p and mRNA level of DNA methyltransferase (DNMT) 1, and miR-29b and DNMT3a/DNMT3b were significantly negatively correlated in biliary atresia livers...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29740327/extracellular-vesicles-as-carriers-of-non-coding-rnas-in-liver-diseases
#13
REVIEW
Junfa Yang, Changyao Li, Lei Zhang, Xiao Wang
Extracellular vesicles (EVs) are small membranous vesicles secreted from normal, diseased, and transformed cells in vitro and in vivo . EVs have been found to play a critical role in cell-to-cell communication by transferring non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long ncRNAs (lncRNAs) and so on. Emerging evidence shows that transferring biological information through EVs to neighboring cells in intercellular communication not only keep physiological functions, but also participate in the pathogenesis of liver diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29739113/combination-of-micrornas-and-cytokines-a-method-for-better-evaluation-of-acute-on-chronic-liver-failure
#14
Chunwen Pu, Chunmeng Jiang, Lang Lang, Huang Hui, Zhidong Wang, Dapeng Ma, Yong Zhang
BACKGROUND: The aim was to establish expression profiles of microRNAs (miRNAs) in Peripheral Blood Mononuclear Cells (PBMC) and of plasma cytokines from the patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) and high-risk of acute-on-chronic liver failure (ACLF) patients as well as healthy people and to examine the relationships between these profiles and clinical features. METHODS: Herein, we collected PBMCs and plasma from peripheral blood of HBV-ACLF and ACLF patients as well as healthy people...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738828/time-course-expression-profile-and-diagnostic-potential-of-a-mirna-panel-in-exosomes-and-total-serum-in-acute-liver-injury
#15
Tarek K Motawi, Mohamed R Mohamed, Nancy N Shahin, Mohamed A M Ali, May A Azzam
Circulating miRNAs have recently emerged as attractive candidates for biomarker discovery. However, they have a variant distribution in circulation, and the diagnostic significance of their compartmentalization is yet to be elucidated. This study explored the time-course expression profile and the diagnostic potential of miRNAs-122a-5p, 192-5p, 193a-3p and 194-5p in exosomal and total serum compartments in two rat models of acute liver injury (ALI)1 . Exosomes were isolated and characterized in terms of morphology, size and CD-63 surface marker expression...
May 5, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29736311/mir-337-3p-suppresses-the-proliferation-and-invasion-of-hepatocellular-carcinoma-cells-through-targeting-jak2
#16
Xue-Liang Zuo, Zhi-Qiang Chen, Jun-Feng Wang, Jin-Guo Wang, Lin-Hu Liang, Juan Cai
Accumulating evidence has indicated that microRNA (miRNA) dysregulation contributes to hepatocellular carcinoma (HCC) progression. miR-337-3p is downregulated in gastric cancer and neuroblastoma; however, its biological function and underlying mechanism in HCC remain unclear. In this study, we showed that the expression level of miR-337-3p was significantly decreased in HCC, and was associated with several clinicopathological characteristics, including tumor multiplicity, histological differentiation, and Barcelona Clinic Liver Cancer stage...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29735795/lncrna-regulated-autophagy-and-its-potential-role-in-drug-induced-liver-injury
#17
Juan Zhou, Yi Li, XinYu Liu, Yunzhu Long, Jun Chen
BACKGROUND AND AIM: Autophagy and its regulated pathways participate in many important cellular physiology and pathological processes involving protein aggregates, damaged mitochondria, excessive peroxisomes, ribosomes, and invading pathogens. This study aimed to review recently published studies and further describe the long noncoding RNA (lncRNA)-regulated autophagy during drug-induced liver injury (DILI). MATERIAL AND METHODS: DILI, autophagy, autophagy-related genes (ATGs), and lncRNA were used as key words to search published studies from PubMed, Google Scholar, and Web of Science...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29734428/characterization-of-mirnas-modulated-by-torpor-in-the-hibernating-ground-squirrel-ictidomys-tridecemlineatus-liver-by-next-generation-sequencing
#18
M D Morin, D Lang-Ouellette, P J Lyons, N Crapoulet, P Morin
BACKGROUND: Mammalian hibernation is a fascinating phenomenon that involves multiple molecular and biochemical changes to proceed. While the molecular picture associated with torpor has become clearer in recent years, the function of non-coding RNAs, and especially of microRNAs, solicited during this process is not well understood. OBJECTIVE: To better characterize a signature of cold torpor-associated miRNAs in the hibernating thirteen-lined ground squirrel Ictidomys tridecemlineatus...
July 2017: Cryo Letters
https://www.readbyqxmd.com/read/29734164/microrna-873-promotes-cell-proliferation-migration-and-invasion-by-directly-targeting-tslc1-in-hepatocellular-carcinoma
#19
Guoyong Han, Long Zhang, Xuhao Ni, Zhiqiang Chen, Xiongxiong Pan, Qin Zhu, Shu Li, Jindao Wu, Xinli Huang, Xuehao Wang
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has the third highest mortality rate among all cancers. MicroRNAs are a class of endogenous, single-stranded short noncoding RNAs. The purpose of this study was to study the role of microRNA-873 in HCC. METHODS: The expression of miRNA-873 and tumor suppressor in lung cancer 1 (TSLC1) in HCC tissues and cell lines was detected by real-time quantitative RT-PCR (RT-qPCR) or western blot...
May 3, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29731866/microrna-hsa-let-7e-5p-as-a-potential-prognosis-marker-for-rectal-carcinoma-with-liver-metastases
#20
Wenfeng Chen, Guosheng Lin, Yizhou Yao, Jishen Chen, Hanli Shui, Qinghai Yang, Xiaoya Wang, Xiaoyuan Weng, Ling Sun, Fei Chen, Sheng Yang, Yufeng Yang, Yongjian Zhou
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression that target mRNAs for translational repression or cleavage. The present study was conducted to identify differentially expressed miRNAs in primary tumor tissues of rectal carcinoma (RC) that may be associated with heterochrony hepatic metastasis (HHM). Samples were collected exclusively from patients with RC but not colon cancer (CC); Next-generation high-throughput sequencing technology and bioinformatics tools were used to profile and analyze small RNAs and their corresponding targets in primary tumor tissues with HHM (n=2) or without metastases (non-metastatic, NM; n=2)...
May 2018: Oncology Letters
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