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miRNA hcc

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https://www.readbyqxmd.com/read/29345291/microrna-1271-functions-as-a-metastasis-and-epithelial-mesenchymal-transition-inhibitor-in-human-hcc-by-targeting-the-ptp4a1-c-src-axis
#1
Chao Li, Yezhen Jiang, Runchen Miao, Kai Qu, Jingyao Zhang, Chang Liu
MicroRNAs (miRNAs or miRs) have been shown to regulate hepatocellular carcinoma (HCC) metastasis. In the present study, we focused on the functions of miR-1271 in HCC metastasis. The downregulation of miR-1271 was found to be associated with to venous infiltration, an advanced TNM stage (III+IV stage) and a shorter survival time. Our in vitro and in vivo data demonstrated that miR-1271 prevented HCC cell migration and invasion, as well as the formation of lung metastatic clusters. In addition, miR-1271 was demonstrated to markedly inhibit the epithelial-mesenchymal transition (EMT) of HCC cells...
February 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29335523/mir-139-5p-inhibits-aerobic-glycolysis-cell-proliferation-migration-and-invasion-in-hepatocellular-carcinoma-via-a-reciprocal-regulatory-interaction-with-ets1
#2
Shengni Hua, Ling Lei, Ling Deng, Xie Weng, Chengdong Liu, Xiaolong Qi, Shuang Wang, Dongyan Zhang, Xuejing Zou, Chuanhui Cao, Li Liu, Dehua Wu
Cancer cells have metabolic features that allow them to preferentially metabolize glucose through aerobic glycolysis, providing them with a progression advantage. However, microRNA (miRNA) regulation of aerobic glycolysis in cancer cells has not been extensively investigated. We addressed this in the present study by examining the regulation of miR-139-5p on aerobic glycolysis of hepatocellular carcinoma (HCC) using clinical specimens, HCC cells, and a mouse xenograft model. We found that overexpressing miR-139-5p restrained aerobic glycolysis, suppressing proliferation, migration, and invasion in HCC cells...
January 16, 2018: Oncogene
https://www.readbyqxmd.com/read/29333940/expression-analysis-of-liver-specific-circulating-micrornas-in-hcv-induced-hepatocellular-carcinoma-in-egyptian-patients
#3
Lobna Mourad, Eman El-Ahwany, Mona Zoheiry, Hoda Abu-Taleb, Marwa Hassan, Amged Ouf, Ali Abdel Rahim, Moataz Hassan, Suher Zada
OBJECTIVES: Due to the absence of reliable and accurate biomarkers for the early detection of liver malignancy, circulating microRNAs have recently emerged as great candidates for prompt cancer identification. Therefore, the aim of this study was to investigate the potential of liver-specific circulating microRNAs as an accurate non-invasive diagnostic tool for early diagnosis of hepatitis C virus (HCV)-induced hepatocellular carcinoma (HCC). METHODOLOGY: A total of 165 patients were enrolled in this study and categorized into four main groups: 42 chronic hepatitis C (CHC) without cirrhosis, 45 CHC with cirrhosis (LC), 38 HCC with HCV patients, and 40 healthy controls...
January 15, 2018: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29332449/mir-452-3p-a-potential-tumor-promoter-that-targets-the-cpeb3-egfr-axis-in-human-hepatocellular-carcinoma
#4
Hui Tang, Jianwen Zhang, Zhenyu Yu, Linsen Ye, Kun Li, Fan Ding, Xiao Feng, Wei Meng
PURPOSE: We proposed to investigate the effects of miR-452-3p on the proliferation and mobility of hepatocellular carcinoma (HCC) cells by targeting cytoplasmic polyadenylation element binding protein 3/estimated glomerular filtration rate (CPEB3/EGFR) axis. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect miR-452-3p expression in 84 pairs of HCC tissues and adjacent tissues. Luciferase reporter assay was employed to examine the relationship between miR-452-3p and CPEB3...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29328436/role-of-exosomes-and-exosomal-micrornas-in-hepatocellular-carcinoma-potential-in-diagnosis-and-antitumour-treatments-review
#5
Jing-Hua Pan, Hong Zhou, Xiao-Xu Zhao, Hui Ding, Wei Li, Li Qin, Yun-Long Pan
Communication between hepatocellular carcinoma (HCC) cells and their environment is essential for the development and progression of HCC. Exosomes, which are microvesicles secreted by a number of cell types, are carriers of intercellular information and regulate the tumour microenvironment. Studies have demonstrated that exosomes are involved in the communication between HCC cells, endothelial cells and stem cells, and that they serve important roles in the metastasis and invasion, immune evasion and immunotherapy of HCC...
January 11, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29322794/integrated-analysis-of-the-rna-seq-data-of-liver-hepatocellular-carcinoma
#6
H Xue, L Luo, Y T Yao, L L Wei, S P Deng, X L Huang
The present study aimed to explore the genetic changes involved in the liver hepatocellular carcinoma (HCC) development. The RNA-Seq data of 212 HCC tissue samples and 50 normal tissue samples were downloaded using TCGA-Assembler. A total of 4 subgroups were obtained, and 4167, 6279, 5379, and 2548 DEGs were screened in group 1, group 2, group 3, and group 4, respectively. Enrichment analysis found that cell cycle, metabolism, and translation related terms were the most significantly changed functions and pathways...
2018: Neoplasma
https://www.readbyqxmd.com/read/29322790/integrated-network-analysis-to-identify-the-key-genes-transcription-factors-and-micrornas-involved-in-hepatocellular-carcinoma
#7
S Q Shi, J-J Ke, Q S Xu, W Q Wu, Y Y Wan
HCC (hepatocellular carcinoma), which can be induced by cirrhosis and viral hepatitis infection, is the most frequent form of liver cancer. This study is performed to investigate the mechanisms of HCC. GSE57957 was obtained from Gene Expression Omnibus database, including 39 HCC samples and 39 adjacent non-tumorous samples. The DEGs (differentially expressed genes) were screened using the limma package in R, and then were conducted with enrichment analysis using "BioCloud" platform. Using STRING database, WebGestalt tool, as well as ITFP and TRANSFAC databases, PPI (protein-protein interaction) pairs, miRNA (microRNA)-target pairs, and TF (transcription factor)-target pairs separately were predicted...
2018: Neoplasma
https://www.readbyqxmd.com/read/29321958/diagnostic-value-of-strand-specific-mirna-101-3p-and-mirna-101-5p-for-hepatocellular-carcinoma-and-a-bioinformatic-analysis-of-their-possible-mechanism-of-action
#8
Xia Yang, Yu-Yan Pang, Rong-Quan He, Peng Lin, Jie-Mei Cen, Hong Yang, Jie Ma, Gang Chen
There is accumulating evidence that miRNA might serve as potential diagnostic and prognostic markers for various types of cancer. Hepatocellular carcinoma (HCC) is the most common type of malignant lesion but the significance of miRNAs in HCC remains largely unknown. The present study aimed to establish the diagnostic value of miR-101-3p/5p in HCC and then further investigate the prospective molecular mechanism via a bioinformatic analysis. First, the miR-101 expression profiles and parallel clinical parameters from 362 HCC patients and 50 adjacent non-HCC tissue samples were downloaded from The Cancer Genome Atlas (TCGA)...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29314614/aberrant-expression-of-micrornas-and-the-mir-1-met-pathway-in-canine-hepatocellular-carcinoma
#9
Y-C Lai, N Ushio, M M Rahman, Y Katanoda, K Ogihara, Y Naya, A Moriyama, T Iwanaga, Y Saitoh, T Sogawa, T Sunaga, Y Momoi, H Izumi, N Miyoshi, Y Endo, M Fujiki, H Kawaguchi, N Miura
Canine hepatocellular carcinoma (HCC) is the most common primary hepatic tumour in dogs. MicroRNA (miRNA) dysregulation has been reported in human HCC and shown to have diagnostic and prognostic value; however, there are no data on miRNA expression in canine HCC. The aim of the present study was to investigate differentially expressed miRNAs in canine HCC. Analysis of miRNA expression in canine HCC tissues and cell lines by quantitative reverse transcription PCR showed that miR-1, miR-122, let-7a, and let-7g were downregulated, whereas miR-10b and miR-21 were upregulated in canine HCC...
January 3, 2018: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29312628/mir-520f-promotes-cell-aggressiveness-by-regulating-fibroblast-growth-factor-16-in-hepatocellular-carcinoma
#10
Feng Feng Xu, Wen Feng Xie, Guo Qing Zha, Hong Wu Chen, Liang Deng
Cancer metastasis is a multistep cellular process, which has be confirmed one of mainly causes of cancer associated-death in hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) participate in tumorigenesis function as either tumor suppressor genes or oncogenes. In order to elaborate the critical miRNAs and their targets in HCC, we compared the differential expression of miRNA between HCC tissues and normal tissues. Microarray analysis revealed there were several significantly up-expression miRNAs in HCC, compared to normal solid tissue...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29310356/combined-low-mirna-29s-is-an-independent-risk-factor-in-predicting-prognosis-of-patients-with-hepatocellular-carcinoma-after-hepatectomy-a-chinese-population-based-study
#11
Zhen Zhang, Shiqiang Shen
The prediction of prognosis of hepatocellular carcinoma (HCC) following partial hepatectomy is still an unresolved issue. The aim of this study is to identify the association between miRNA-29s family and the prognosis of patients with HCC in a large Asian cohort. We retrospectively reviewed 122 patients with HCC managed in our institution between 2008 and 2015. The expression of miRNA-29s was detected by real-time polymerase chain reaction (PCR). Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazards models...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305580/the-epigenetically-regulated-mir-494-associates-with-stem-cell-phenotype-and-induces-sorafenib-resistance-in-hepatocellular-carcinoma
#12
Daniela Pollutri, Clarissa Patrizi, Sara Marinelli, Catia Giovannini, Elena Trombetta, Ferdinando A Giannone, Maurizio Baldassarre, Santina Quarta, Y P Vandewynckel, A Vandierendonck, H Van Vlierberghe, Laura Porretti, Massimo Negrini, Luigi Bolondi, Laura Gramantieri, Francesca Fornari
Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, especially in patients not amenable for curative treatments. The multi-kinase inhibitor sorafenib represents the first-line treatment option for advanced HCC; nevertheless, its effectiveness is limited due to tumor heterogeneity as well as innate or acquired drug resistance, raising the need for new therapeutic strategies. MicroRNAs (miRNAs) involvement in treatment response as well as their safety and efficacy in preclinical models and clinical trials have been widely documented in the oncologic field, including HCC...
January 5, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29295728/mir-136-inhibits-malignant-progression-of-hepatocellular-carcinoma-cells-by-targeting-cyclooxygenase-2
#13
Haiyan Jia, Hong Wang, Yanfen Yao, Chunlei Wang, Pibao Li
MicroRNAs (miRNAs) play a vital role in regulating tumor progression. Dysregulated miR-136expression was linked to thedevelopment of various human cancers. In the present study, we investigated the expression and relationship of miR-136 and COX2in hepatocellular carcinoma (HCC) using relevant experiments, involving CCK-8, Transwell assay, and luciferase-reporter assay. We demonstrated that miR-136 expression is obviously decreased in HCC tissues and cells, and negatively correlated with the expression of COX2 mRNA...
January 2, 2018: Oncology Research
https://www.readbyqxmd.com/read/29295726/mir-346-promotes-hcc-progression-by-suppressing-breast-cancer-metastasis-suppressor-1-expression
#14
Zhixian Guo, Jingjing Li, Jihong Sun, Lu Sun, Yubing Zhou, Zujiang Yu
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors all around the world. MicroRNA (miRNA) is a class of non coding single stranded RNA molecules, involved in regulating cancer cell proliferation, metastasis, migration, invasion and apoptosis. We showed that the expression of miR-346 was significantly increased in HCC tissues and cell lines, compared with non-cancerous controls, and was associated with poor prognosis. Over-expression of miR-346 promoted proliferation and inhibited apoptosis of SMMC-7721 cells, while knockdown of miR-346 significantly suppressed proliferation and induced apoptosis of HepG2 cells...
January 2, 2018: Oncology Research
https://www.readbyqxmd.com/read/29291025/prognostic-value-of-micrornas-in-hepatocellular-carcinoma-a-meta-analysis
#15
Yue Zhang, Chao Wei, Cong-Cong Guo, Rong-Xiu Bi, Jin Xie, Dong-Hui Guan, Chuan-Hua Yang, Yue-Hua Jiang
Background: Numerous articles reported that dysregulated expression levels of miRNAs correlated with survival time of HCC patients. However, there has not been a comprehensive meta-analysis to evaluate the accurate prognostic value of miRNAs in HCC. Design: Meta-analysis. Materials and Methods: Studies, published in English, estimating expression levels of miRNAs with any survival curves in HCC were identified up until 15 April, 2017 by performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews by two independent authors...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29283330/mirna-in-hepatocellular-carcinoma-pathogenesis-and-therapeutic-approaches
#16
Muhammad Imran Qadir, Samana Zahra Rizvi
Hepatocellular carcinoma (HCC) is a worldwide disease. Because therapeutic measures are ineffective, HCC currently has a poor prognosis. The main causes of HCCs are alcoholism, hepatitis, and metabolic syndrome. Normally hygieinic studies revealed that there is lower survival rate of HCC. MicroRNAs (miRNAs) consist of short noncoding sequences of RNA (20 to 24 nucleotides), which posttranscriptionally regulate the expression of the protein coding genes. MicroRNAs have been proposed to be prospective therapeutic molecules and targets...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29282036/circulating-microrna-s-as-a-diagnostic-tool-for-hepatocellular-carcinoma-in-a-hyper-endemic-hiv-setting-kwazulu-natal-south-africa-a-case-control-study-protocol-focusing-on-viral-etiology
#17
K Sartorius, B Sartorius, A Kramvis, E Singh, A Turchinovich, B Burwinkel, T Madiba, C A Winkler
BACKGROUND: A wide range of studies has investigated the diagnostic proficiency of extracellular microRNAs (miRNAs) in hepatocellular cancer (HCC). HCC is expected to increase in Sub-Saharan Africa (SSA), due to endemic levels of viral infection (HBV/HIV), ageing and changing lifestyles. This unique aetiological background provides an opportunity for investigating potentially novel circulating miRNAs as biomarkers for HCC in a prospective study in South Africa. METHODS: This study will recruit HCC patients from two South African cancer hospitals, situated in Durban and Pietermaritzburg in the province of KwaZulu-Natal...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29280338/rodlike-supramolecular-nanoassemblies-of-degradable-poly-aspartic-acid-derivatives-and-hydroxyl-rich-polycations-for-effective-delivery-of-versatile-tumor-suppressive-ncrnas
#18
Hai-Qing Song, Wenting Pan, Rui-Quan Li, Bingran Yu, Wenjuan Liu, Ming Yang, Fu-Jian Xu
The delivery of tumor-suppressive noncoding RNAs (ncRNAs) including short ncRNAs (i.e., miRNAs) and long ncRNAs (lncRNAs) is put forward to treat tumors. In this work, novel rodlike supramolecular nanoassemblies (CNC @CB[8] @ PGEA) of degradable poly(aspartic acid) (PAsp) derivatives-grafted cellulose nanocrystals (CNCs) and hydroxyl-rich polycations (ethanolamine-functionalized poly(glycidyl methacrylate), PGEA) are proposed via typical cucurbit[8]uril (CB[8])-based host-guest interactions for delivery of different ncRNAs to treat hepatocellular carcinoma (HCC)...
December 27, 2017: Small
https://www.readbyqxmd.com/read/29278659/decreased-levels-of-serum-exosomal-mir-638-predict-poor-prognosis-in-hepatocellular-carcinoma
#19
Min Shi, Ye Jiang, Lu Yang, Shushan Yan, Yu-Gang Wang, Xiao-Jie Lu
Currently available studies have implicated that exosome-delivered microRNAs (miRNAs) play crucial roles in human cancer. However, the association of serum exosomal miR-638 and hepatocellular carcinoma (HCC) remains largely unknown. We aim to investigate the expression of exosomal miR-638 in serum of HCC patients and its prognostic role in this deadly disease. Kaplan-Meier and cox regression analyses were used to determine the survival of patients histologically diagnosed with HCC. Reduced levels of exosomal miR-638 in serum samples from patients with HCC were identified by real-time PCR...
December 26, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29249451/mir-199-3p-replacement-affects-e-cadherin-expression-through-notch1-targeting-in-hepatocellular-carcinoma
#20
Catia Giovannini, Francesca Fornari, Rossella Dallo, Martina Gagliardi, Elisa Nipoti, Francesco Vasuri, Camelia Alexandra Coadă, Matteo Ravaioli, Luigi Bolondi, Laura Gramantieri
Hepatocellular carcinoma (HCC) represents the second cause of cancer-related mortality worldwide and is associated with poor prognosis, due to a high recurrence rate after curative treatments and a drug resistance phenotype. In this scenario, the identification of innovative and effective therapeutic strategies is an unmet clinical need. The safety and efficacy of microRNA (miRNA) mediated approaches in preclinical models and clinical trials have been widely described in cancer. MicroRNA-199a downregulation is a common feature of HCC where its reduced expression contributes to mTOR and c-Met pathways activation...
December 14, 2017: Acta Histochemica
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