keyword
https://read.qxmd.com/read/38496249/a-hypoxia-related-mirna-mrna-signature-for-predicting-the-response-and-prognosis-of-transcatheter-arterial-chemoembolization-in-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Shaoqi Zong, Guokai Huang, Bo Pan, Shasha Zhao, Changquan Ling, Binbin Cheng
PURPOSE: Transcatheter arterial chemoembolization (TACE) is commonly used in the treatment of hepatocellular carcinoma (HCC). However, not all patients respond to this treatment. TACE typically leads to hypoxia in the tumor microenvironment. Therefore, we aimed to construct a prognostic model based on hypoxia-related differentially expressed microRNA (miRNAs) in hepatocellular carcinoma (HCC) and to investigate the potential target mRNAs for predicting TACE response. METHODS: The hypoxia-related miRNAs (HRMs) were identified in liver cancer cells, then global test was performed to further select the miRNAs which were associated with recurrence and vascular invasion...
2024: Journal of Hepatocellular Carcinoma
https://read.qxmd.com/read/38494261/screening-of-mirnas-as-prognostic-biomarkers-and-their-associated-hub-targets-across-hepatocellular-carcinoma-using-survival-based-bioinformatics-approach
#2
JOURNAL ARTICLE
Prithvi Singh, Rubi Solanki, Alvea Tasneem, Simran Suri, Harleen Kaur, Sapna Ratan Shah, Ravins Dohare
BACKGROUND: The hepatocellular carcinoma (HCC) incident rate is gradually increasing yearly despite all the research and efforts taken by scientific communities and governing bodies. Approximately 90% of all liver cancer cases belong to HCC. Usually, HCC patients approach the treatment in the late stages of this malignancy which becomes the primary cause of high mortality rate. The knowledge about molecular pathogenesis of HCC is limited and needs more attention from researchers to identify the driver genes and miRNAs, which causes to translate this information into clinical practice...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38482448/the-diagnostic-prognostic-drug-sensitivity-and-cerna-internet-of-ppp4r1-in-liver-hepatocellular-carcinoma-lihc
#3
JOURNAL ARTICLE
Xiaowei Li, Yinglian Pan, Siren Feng, Weimei Xing, Bo Lin, Wei Li, Mengsen Li, Mingyue Zhu
BACKGROUND: Recent studies have reported a role of protein phosphatase 4 regulatory subunit 1 ( PPP4R1 ) in cancer development. However, its expression, diagnostic significance, prognostic value and biological function in liver hepatocellular carcinoma (LIHC) are not known. METHODS: The expression level of PPP4R1 in pan-cancer was evaluated by analyzing publicly accessible data from the University of California Santa Cruz (UCSC) Xena database. The diagnostic value of PPP4R1 for tumors was assessed using receiver operating characteristic (ROC) curves, whereas the impact of PPP4R1 on tumor prognosis was determined using Kaplan-Meier survival curves, and a prognostic model for LIHC was established using cox regression analysis...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38477016/construction-of-a-prognostic-model-based-on-genome-wide-methylation-analysis-of-mirnas-for-hepatocellular-carcinoma
#4
JOURNAL ARTICLE
Zhaoqi Shi, Xiaolong Liu, Duguang Li, Xiaoxiao Fan, Lifeng He, Daizhan Zhou, Hui Lin
Aim: Using the methylation level of miRNA genes to develop a prognostic model for patients with hepatocellular carcinoma (HCC). Materials & methods: least absolute shrinkage and selection operator and multivariate Cox regression analyses were performed to develop a prognostic model. One miRNA in the model was selected for verification. Results: A prognostic model was developed using eight miRNAs. The areas under the curve for predicting overall survival at 1, 3 and 5 years were 0.75, 0.81 and 0...
March 13, 2024: Epigenomics
https://read.qxmd.com/read/38475805/systematic-integration-of-molecular-and-clinical-approaches-in-hcv-induced-hepatocellular-carcinoma
#5
JOURNAL ARTICLE
Ciniso Sylvester Shabangu, Wen-Hsiu Su, Chia-Yang Li, Ming-Lung Yu, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Shu-Chi Wang
BACKGROUND: MicroRNAs (miRNAs) play a crucial role in gene expression and regulation, with dysregulation of miRNA function linked to various diseases, including hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC). There is still a gap in understanding the regulatory relationship between miRNAs and mRNAs in HCV-HCC. This study aimed to investigate the function and effects of persistent HCV-induced miRNA expression on gene regulation in HCC. METHODS: MiRNA array data were used to identify differentially expressed miRNAs and their targets, and miRNAs were analyzed via DIANA for KEGG pathways, gene ontology (GO) functional enrichment, and Ingenuity Pathways Analysis (IPA) for hepatotoxicity, canonical pathways, associated network functions, and interactive networks...
March 12, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38463829/mir-186-5p-prevents-hepatocellular-carcinoma-progression-by-targeting-methyltransferase-like-3-that-regulates-m6a-mediated-stabilization-of-follistatin-like-5
#6
JOURNAL ARTICLE
Shuoshuo Ma, Fangfang Chen, Chuanle Lin, Wanliang Sun, Dongdong Wang, Shuo Zhou, ShiRu Chang, Zheng Lu, Dengyong Zhang
BACKGROUND: Hepatocellular carcinoma (HCC) is a multistep process involving sophisticated genetic, epigenetic, and transcriptional changes. However, studies on microRNA (miRNA)'s regulatory effects of N6-methyladenosine (m6A) modifications on HCC progression are limited. METHODS: Cell Counting Kit-8 (CCK-8), clone formation, and Transwell assays were used to investigate changes in cancer cell proliferation, invasion, and migration. RNA m6A levels were verified using methylated RNA immunoprecipitation...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38463586/expression-of-circular-rna-has-circ-0009158-and-identification-of-associated-mirna-mrna-network-in-hepatocellular-carcinoma
#7
JOURNAL ARTICLE
Lili Sun, Buerlan Yeerkenbieke, Anwaier Yuemaierabola, Fuzhong Liu, Dilinaer Yeerxiati, Xiaogang Dong, Wenjia Guo
Primary hepatocellular carcinoma (HCC) affects people all over the world. Circular RNAs are involved in the growth and development of several malignancies and regulate a number of biological processes. However, the roles of has-circ-0009158 in HCC remain unknown. This study explored the expression and associated miRNA-mRNA network of has-circ-0009158 in HCC. Quantitative real-time polymerase chain reaction was used to measure the expression of hsa-circ-0009158 in the HCC tissues of 143 patients and four human HCC cell lines...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38452654/n-6-methyladenosine-m-6-a-modification-in-hepatocellular-carcinoma
#8
REVIEW
Hehua Ma, Yuxin Hong, Zhenzhen Xu, Zuyi Weng, Yuanxun Yang, Dandan Jin, Zhiyou Chen, Jing Yue, Xuan Zhou, Zhi Xu, Fei Fei, Juan Li, Wei Song
Hepatocellular carcinoma (HCC) is one of the deadliest cancers of human, the tumor-related death of which ranks third among the common malignances. N6 -methyladenosine (m6 A) methylation, the most abundant internal modification of RNA in mammals, participates in the metabolism of mRNA and interrelates with ncRNAs. In this paper, we overviewed the complex function of m6 A regulators in HCC, including regulating the tumorigenesis, progression, prognosis, stemness, metabolic reprogramming, autophagy, ferroptosis, drug resistance and tumor immune microenvironment (TIME)...
March 6, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38424172/elucidating-hepatocellular-carcinoma-progression-a-novel-prognostic-mirna-mrna-network-and-signature-analysis
#9
JOURNAL ARTICLE
Fei Wang, Xichun Kang, Yaoqi Li, Jianhua Lu, Xiling Liu, Huimin Yan
There is increasing evidence that miRNAs play an important role in the prognosis of HCC. There is currently a lack of acknowledged models that accurately predict patient prognosis. The aim of this study is to create a miRNA-based model to precisely forecast a patient's prognosis and a miRNA-mRNA network to investigate the function of a targeted mRNA. TCGA miRNA dataset and survival data of HCC patients were downloaded for differential analysis. The outcomes of variance analysis were subjected to univariate and multivariate Cox regression analyses and LASSO analysis...
February 29, 2024: Scientific Reports
https://read.qxmd.com/read/38424116/circulating-mirna-s-biomarkers-for-early-detection-of-hepatocellular-carcinoma-in-egyptian-patients-based-on-machine-learning-algorithms
#10
JOURNAL ARTICLE
Gehad Ismail Sayed, Mona Solyman, Gamalat El Gedawy, Yasmine S Moemen, Hassan Aboul-Ella, Aboul Ella Hassanien
Liver cancer, which ranks sixth globally and third in cancer-related deaths, is caused by chronic liver disorders and a variety of risk factors. Despite therapeutic improvements, the prognosis for Hepatocellular Carcinoma (HCC) remains poor, with a 5-year survival rate for advanced cases of less than 12%. Although there is a noticeable decrease in the frequency of cases, liver cancer remains a significant worldwide health concern, with estimates surpassing one million cases by 2025. The prevalence of HCC has increased in Egypt, and it includes several neoplasms with distinctive messenger RNA (mRNA) and microRNA (miRNA) expression profiles...
February 29, 2024: Scientific Reports
https://read.qxmd.com/read/38411789/comprehensive-analysis-of-circrna-lncrna-mirna-and-mrna-expression-profiles-and-their-competing-endogenous-rna-networks-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#11
JOURNAL ARTICLE
Shaoying Yan, Peng Fu, Huiming Li, Zikun Huang, Renfeng Shan, Binbin Gong
Pursuing knowledge about circular RNA (circRNA), long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) expression profiles and their competing endogenous RNA (ceRNA) networks in hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) was the focus of this research. Expression patterns of circRNAs, lncRNAs, miRNAs, and mRNAs were searched for in relation to HBV-related HCC using whole-transcriptome sequencing. The expression levels of chosen circRNA, lncRNA, miRNA, and mRNA were analyzed using quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
February 27, 2024: Molecular Biotechnology
https://read.qxmd.com/read/38411272/alternative-splicing-related-long-noncoding-rna-anril-facilitates-hepatocellular-carcinoma-by-targeting-the-mir-199a-5p-srsf1-axis-and-impacting-anillin
#12
JOURNAL ARTICLE
Yifan Zhang, Yiquan Lu, Nan Wang, Yuchen Yang, Fengjie Hao, Xiaochun Fei, Yongjun Chen, Junqing Wang
Hepatocellular carcinoma (HCC) is characterized by aberrant alternative splicing (AS), which plays an important part in the pathological process of this disease. However, available reports about genes and mechanisms involved in AS process are limited. Our previous research has identified ANRIL as a long noncoding RNA related to the AS process of HCC. Here, we investigated the exact effect and the mechanism of ANRIL on HCC progress. The ANRIL expression profile was validated using the real-time quantitative polymerase chain reaction assay...
February 27, 2024: Molecular Carcinogenesis
https://read.qxmd.com/read/38397091/micrornas-as-plasma-biomarkers-of-hepatocellular-carcinoma-in-patients-with-liver-cirrhosis-a-cross-sectional-study
#13
JOURNAL ARTICLE
Robin Zenlander, Hugh Salter, Stefan Gilg, Gösta Eggertsen, Per Stål
Ultrasound screening for hepatocellular carcinoma (HCC) in patients with liver cirrhosis has a poor sensitivity for small tumors. Circulating microRNAs (miRNAs) have been explored as HCC biomarkers, but results are diverging. Here, we evaluate if miRNAs up-regulated in HCC tissue can be detected in plasma and used as screening biomarkers for HCC. In this cross-sectional study, plasma, HCC tissue and surrounding non-tumorous liver tissue were collected from liver resections. Tissue miRNAs were identified and quantitated by RNA-sequencing analysis, and the fold-changes between HCC and surrounding liver tissue were calculated...
February 19, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38375688/exosomal-mir-93-derived-from-hepatocellular-carcinoma-cell-promotes-the-sorafenib-resistance-of-hepatocellular-carcinoma-through-pten-pi3k-akt-pathway
#14
JOURNAL ARTICLE
Yuanpeng Bao, Song Xu, Junjing Zhou, Chongyong Zhao, Saimin Dai, Yong Zhang, Min Rao
Exosomal microRNAs (miRNAs) derived from cancer cell is an important regulatory molecule that mediates the formation of tumor drug resistance, but function and mechanisms of exosomal miRNA in sorafenib resistance of hepatocellular carcinoma (HCC) have not been studied. We detected the level and prognosis of miR-93 in HCC by using TCGA HCC database. For confirming the extracted exosome, transmission electron microscopy was used. Cy3-labeled miR-93 and quantitative reverse transcription-polymerase chain reaction were used to prove that exosomal miR-93 derived from HCC cell can be transferred to sensitive HCC cells...
March 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38365080/the-role-of-mir-222-2p-in-exosomes-secreted-by-hexavalent-chromium-induced-premature-senescent-hepatocytes-as-a-sasp-component
#15
JOURNAL ARTICLE
Yu Ma, Siwen Li, Shuzi Ye, Sijia Luo, Lai Wei, Ying Su, Yuan Zeng, Yan Shi, Huanfeng Bian, Fang Xiao
With the development of world industrialization, the environmental pollution of hexavalent chromium [Cr(VI)] is becoming an increasingly serious problem. In particular, the mechanisms by which long-term and low-dose exposure to Cr(VI) leading the development of related cancers are not well understood. As senescent cells gradually lose their ability to proliferate and divide, they will not be malignantly transformed. However, Senescence-associated secretory phenotype (SASP) released by senescent cells into the cellular microenvironment can act on neighboring cells...
February 14, 2024: Environmental Pollution
https://read.qxmd.com/read/38364252/mir-557-inhibits-hepatocellular-carcinoma-progression-through-wnt-%C3%AE-catenin-signaling-pathway-by-targeting-rab10
#16
JOURNAL ARTICLE
Xiaoye Cheng, Can Wu, Haocheng Xu, Ruixiang Zou, Taiyuan Li, Shanping Ye
Accumulating evidence suggests that aberrant miRNAs participate in carcinogenesis and progression of hepatocellular carcinoma (HCC). Abnormal miR-557 expression is reported to interfere with the progression of several human cancers. However, the potential roles of miR-557 in HCC remain largely unknown. In the current study, we found that miR-557 was down-regulated in HCC tissues and cell lines, and was closely related to recurrence and metastasis of HCC. Notably, overexpression of miR-557 inhibited proliferation, migration, invasion, epithelial-to-mesenchymal transition (EMT) progression, blocked cells in G0/G1 phase of MHCC-97H cells in vitro , and suppressed tumor growth in vivo ...
February 15, 2024: Aging
https://read.qxmd.com/read/38357004/the-role-of-competing-endogenous-rna-network-in-the-development-of-hepatocellular-carcinoma-potential-therapeutic-targets
#17
REVIEW
Ziwei Tang, Xue Li, Yanfeng Zheng, Jin Liu, Chao Liu, Xia Li
The current situation of hepatocellular carcinoma (HCC) management is challenging due to its high incidence, mortality, recurrence and metastasis. Recent advances in gene genetic and expression regulation have unveiled the significant role of non-coding RNA (ncRNA) in various cancers. This led to the formulation of the competing endogenous RNA (ceRNA) hypothesis, which posits that both coding RNA and ncRNA, containing miRNA response elements (MRE), can share the same miRNA sequence. This results in a competitive network between ncRNAs, such as lncRNA and mRNA, allowing them to regulate each other...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38345168/scarb1-encoded-circ-_0029343-induces-p73-splicing-to-promote-growth-and-metastasis-of-hepatocellular-carcinoma-via-mir-486-5p-srsf3-axis
#18
JOURNAL ARTICLE
Shuo Zhu, Shengya Cao, Jinhui Che, Le Zhao, Zhan Su, Deqiang Li, Ruifeng Pei, Lu Xu, Yiren Ding, Wuyuan Zhou
Circular RNAs (circRNAs) exhibit essential regulation in the malignant development of hepatocellular carcinoma (HCC). This study aims to investigate the physiological mechanisms of circ_0029343 encoded by scavenger receptor class B member 1 (SCARB1) involved in the growth and metastasis of HCC. Differentially expressed mRNAs in HCC were obtained, followed by the prediction of target genes of differentially expressed miRNAs and gene ontology and kyoto encyclopedia of genes and genomes analysis on the differentially expressed mRNAs...
February 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38341612/mirnome-targeting-nf-%C3%AE%C2%BAb-signaling-orchestrates-macrophage-triggered-cancer-metastasis-and-recurrence
#19
JOURNAL ARTICLE
Dong-Ping Chen, Jun-Cheng Wang, Zheng-Yu Liu, Pei-Lin Li, Ka-Wo Chan, Xiang-Ning Wu, Wu-De-Xin Yao, Tingting Yao, Dong-Ming Kuang, Yuan Wei
Whether and how tumor intrinsic signature determines macrophage-elicited metastasis remains elusive. Here, we showed, in detailed studies of data regarding 7477 patients of 20 types of human cancers, that only 13.8% ± 2.6%/27.9% ± 3.03% of patients with high macrophage infiltration index exhibit early recurrence/vascular invasion. In parallel, although macrophages enhance the motility of various hepatoma cells, their enhancement intensity is significantly heterogeneous. We identify that the expression of malignant Dicer, a ribonuclease that cleaves miRNA precursors into mature miRNAs, determines macrophage-elicited metastasis...
February 9, 2024: Molecular Therapy
https://read.qxmd.com/read/38334941/celestial-insights-unraveling-the-role-of-mir-3682-3p-in-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Pei-Dong Miao, Ying Li, Yu-Dong Jiang
Hepatocellular carcinoma (HCC) remains a formidable oncological challenge, calling for innovative therapeutic strategies to improve patient outcomes. MicroRNAs (miRNAs) have emerged as key regulators in cancer, and miR-3682-3p shows potential as a diagnostic and prognostic biomarker in HCC. We conducted a comprehensive study to uncover its role in HCC biology, revealing dysregulation and clinical associations. Target gene analysis provided insights into potential molecular mechanisms. Moreover, we explored its impact on the tumor microenvironment, immune cell infiltration, and therapy responses...
February 9, 2024: Clinical and Translational Gastroenterology
keyword
keyword
73522
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.