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https://www.readbyqxmd.com/read/27926982/trpv4-channels-mediate-na-k-cl-co-transporter-induced-brain-edema-after-traumatic-brain-injury
#1
Kwok-Tung Lu, Tai-Chun Huang, Ya-Hsin Tsai, Yi-Ling Yang
Na(+) -K(+) -2Cl(-) co-transporter (NKCC1) plays an important role in traumatic brain injury (TBI)-induced brain edema via the mitogen-activated protein kinases (MAPK) cascade. The transient receptor potential vanilloid type 4 (TRPV4) channel participates in neurogenic inflammation, pain transmission and edema. In this study, we investigated the relationship between NKCC1 and TRPV4 and the related signaling pathways in TBI-induced brain edema and neuronal damage. TBI was induced by the calibrated weight-drop device...
December 7, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27926827/decoding-hand-gestures-from-primary-somatosensory-cortex-using-high-density-ecog
#2
Mariana P Branco, Zachary V Freudenburg, Erik J Aarnoutse, Martin G Bleichner, Mariska J Vansteensel, Nick F Ramsey
Electrocorticography (ECoG) based Brain-Computer Interfaces (BCIs) have been proposed as a way to restore and replace motor function or communication in severely paralyzed people. To date, most motor-based BCIs have either focused on the sensorimotor cortex as a whole or on the primary motor cortex (M1) as a source of signals for this purpose. Still, target areas for BCI are not confined to M1, and more brain regions may provide suitable BCI control signals. A logical candidate is the primary somatosensory cortex (S1), which not only shares similar somatotopic organization to M1, but also has been suggested to have a role beyond sensory feedback during movement execution...
December 4, 2016: NeuroImage
https://www.readbyqxmd.com/read/27926766/teledermatology-for-the-diagnosis-and-management-of-skin-cancer-a-systematic-review
#3
Anna Finnane, Kathy Dallest, Monika Janda, H Peter Soyer
Importance: As technology becomes more commonplace in dermatological practice, it is essential to continuously review the accuracy of teledermatology devices and services compared with in-person care. The last systematic review was conducted over 5 years ago. Objective: To synthesize and assess the quality of the evidence to address 3 research questions: (1) How accurate is teledermatology for skin cancer diagnosis compared with usual care (face-to-face [FTF] diagnosis)? (2) Does teledermatology save clinician and/or patient time, compared with usual care? (3) What are the enablers and barriers to adoption of teledermatology in clinical practice for the diagnosis of skin cancer? Evidence Review: The review protocol was registered in the PROSPERO database...
December 7, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27926704/medtronic-automated-insulin-delivery-device-gets-fda-nod
#4
Eric Smalley
No abstract text is available yet for this article.
December 7, 2016: Nature Biotechnology
https://www.readbyqxmd.com/read/27926652/hysteroscopic-sterilization-with-essure-summary-of-the-u-s-food-and-drug-administration-actions-and-policy-implications-for-postmarketing-surveillance
#5
Jessica R Walter, Comeron W Ghobadi, Emily Hayman, Shuai Xu
In September 2015, the U.S. Food and Drug Administration (FDA) convened a meeting of the Obstetrics and Gynecology Advisory Board Committee to address the sudden increase of patient-reported adverse events surrounding Essure, a Class III device offering a less invasive method for permanent female sterilization. After a review of the premarketing and postmarketing data and existing scientific literature, the FDA concluded there was insufficient evidence to remove the device from the market. However, the FDA did release a new guidance document requiring a black box warning for the device and ordered a new postmarketing study comparing Essure's safety and efficacy with laparoscopic tubal sterilization...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926617/robotic-approaches-for-the-rehabilitation-of-upper-limb-recovery-after-stroke-a-systematic-review-and-meta-analysis
#6
Chao Zhang, Cecilia W P Li-Tsang, Ricky K C Au
This systematic review with a meta-analysis of studies was carried out to evaluate the effectiveness of robotic training (RT) and conventional training (CT) in improving the motor recovery of paretic upper limbs in stroke patients. Numerous electronic databases were searched from January 2000 to May 2016. Finally, 13 randomized-controlled trials fulfilled the inclusion criteria and were included in the three meta-analyses. The first meta-analysis carried out for those studies using RT for stroke patients indicated a significant improvement in the RT groups...
December 6, 2016: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/27926562/long-term-experience-of-magnetic-anal-sphincter-augmentation-in-patients-with-fecal-incontinence
#7
Jeremy Sugrue, Paul-Antoine Lehur, Robert D Madoff, Shane McNevin, Steen Buntzen, Søren Laurberg, Anders Mellgren
BACKGROUND: Magnetic anal sphincter augmentation is a novel technique for the treatment of patients with fecal incontinence. OBJECTIVE: The current study reports the long-term effectiveness and safety of this new treatment modality. DESIGN: This was a prospective multicenter pilot study. SETTINGS: The study was performed at 4 clinical sites in Europe and the United States. PATIENTS: The cohort included patients with severe fecal incontinence for ≥6 months who had previously failed conservative therapy and were implanted with a magnetic anal sphincter device between 2008 and 2011...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27925849/development-and-prospective-federal-state-wide-evaluation-of-a-device-for-height-based-dose-recommendations-in-prehospital-pediatric-emergencies-a-simple-tool-to-prevent-most-severe-drug-errors
#8
Jost Kaufmann, Bernhard Roth, Thomas Engelhardt, Alex Lechleuthner, Michael Laschat, Christoph Hadamitzky, Frank Wappler, Martin Hellmich
OBJECTIVE: Drug dosing errors pose a particular threat to children in prehospital emergency care. With the Pediatric emergency ruler (PaedER), we developed a simple height-based dose recommendation system and evaluated its effectiveness in a pre-post interventional trial as the Ethics Committee disapproved randomization due to the expected positive effect of the PaedER on outcome. METHODS: Pre-interventional data were retrospectively retrieved from the electronic records and medical protocols of the Cologne Emergency Medical Service over a two-year period prior to the introduction of the PaedER...
December 7, 2016: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27925741/ultratransparent-media-and-transformation-optics-with-shifted-spatial-dispersions
#9
Jie Luo, Yuting Yang, Zhongqi Yao, Weixin Lu, Bo Hou, Zhi Hong Hang, C T Chan, Yun Lai
By using pure dielectric photonic crystals, we demonstrate the realization of ultratransparent media, which allow near 100% transmission of light for all incident angles and create aberration-free virtual images. The ultratransparency effect is well explained by spatially dispersive effective medium theory for photonic crystals, and verified by both simulations and proof-of-principle microwave experiments. Designed with shifted elliptical equal frequency contours, such ultratransparent media not only provide a low-loss and feasible platform for transformation optics devices at optical frequencies, but also enable new freedom for phase manipulation beyond the local medium framework...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925715/trapped-ion-quantum-logic-with-global-radiation-fields
#10
S Weidt, J Randall, S C Webster, K Lake, A E Webb, I Cohen, T Navickas, B Lekitsch, A Retzker, W K Hensinger
Trapped ions are a promising tool for building a large-scale quantum computer. However, the number of required radiation fields for the realization of quantum gates in any proposed ion-based architecture scales with the number of ions within the quantum computer, posing a major obstacle when imagining a device with millions of ions. Here, we present a fundamentally different approach for trapped-ion quantum computing where this detrimental scaling vanishes. The method is based on individually controlled voltages applied to each logic gate location to facilitate the actual gate operation analogous to a traditional transistor architecture within a classical computer processor...
November 25, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27925592/enzyme-free-scalable-dna-digital-design-techniques-a-review
#11
Aby Konampurath George, Harpreet Singh
With the recent developments in DNA nanotechnology, DNA has been used as the basic building block for the design of nanostructures, autonomous molecular motors, various devices, and circuits. DNA is considered as a possible candidate for replacing silicon for designing digital circuits in a near future, especially in implantable medical devices, because of its parallelism, computational powers, small size, light weight, and compatibility with bio-signals. The research in DNA digital design is in early stages of development, and electrical and computer engineers are not much attracted towards this field...
December 2, 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27925591/kinesthetic-feedback-during-2dof-wrist-movements-via-a-novel-mr-compatible-robot
#12
Andrew Erwin, Marcia O'Malley, David Ress, Fabrizio Sergi
We demonstrate the interaction control capabilities of the MR-SoftWrist, a novel MR-compatible robot capable of applying accurate kinesthetic feedback to wrist pointing movements executed during fMRI. The MR-SoftWrist, based on a novel design that combines parallel piezoelectric actuation with compliant force feedback, is capable of delivering 1.5 N·m of torque to the wrist of an interacting subject about the flexion/extension and radial/ulnar axes. The robot workspace, defined by admissible wrist rotation angles, fully includes a circle with a 20 deg radius...
December 1, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/27925584/topological-analysis-and-gaussian-decision-tree-effective-representation-and-classification-of-biosignals-of-small-sample-size
#13
Zhifei Zhang, Yang Song, Haochen Cui, Jayne Wu, Fernando Schwartz, Hairong Qi
GOAL: Bucking the trend of big data, in microdevice engineering, small sample size is common, especially when the device is still at the proof-of-concept stage. The small sample size, small inter-class variation, and large intra-class variation, have brought biosignal analysis new challenges. Novel representation and classification approaches need to be developed to effectively recognize targets of interests with the absence of a large training set. METHODS: Moving away from the traditional signal analysis in the spatiotemporal domain, we exploit the biosignal representation in the topological domain that would reveal the intrinsic structure of point clouds generated from the biosignal...
December 2, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27925461/in-it-for-the-long-haul-the-cytocompatibility-of-aged-graphene-oxide-and-its-degradation-products
#14
Brian D Holt, Anne M Arnold, Stefanie A Sydlik
Synthetic biomaterials are poised to transform medicine; however, current synthetic options have yet to ideally recapitulate the desirable properties of native tissue. Thus, the development of new synthetic biomaterials remains an active challenge. Due to its excellent properties, including electrical conductivity, water dispersibility, and capacity for functionalization, graphene oxide (GO) holds potential for myriads of applications, including biological devices. While many studies have evaluated the compatibility of freshly prepared GO, understanding the compatibility of GO as it ages in an aqueous environment is crucial for its safe implementation in long-term biological applications...
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27925412/in-situ-raman-spectroscopic-studies-on-concentration-of-electrolyte-salt-in-lithium-ion-batteries-by-using-ultrafine-multi-fiber-probes
#15
Toshiro Yamanaka, Hiroe Nakagawa, Shigetaka Tsubouchi, Yasuhiro Domi, Takayuki Doi, Takeshi Abe, Zempachi Ogumi
Lithium ion batteries have attracted considerable attention due to their high power density. The change in concentration of salt in the electrolyte solution in lithium ion batteries during operation causes serious degradation of battery performance. In this work, a new method of in situ Raman spectroscopy using ultrafine multi-fiber probes was developed to simultaneously study the concentrations of ions at several different positions in the electrolyte solution in deep narrow spaces between the electrodes in batteries...
December 7, 2016: ChemSusChem
https://www.readbyqxmd.com/read/27925381/doctors-use-of-mobile-devices-in-the-clinical-setting-a-mixed-methods-study
#16
Arany Nerminathan, Amanda Harrison, Megan Phelps, Karen M Scott
AIM: To explore how doctors use mobile devices in the clinical setting and understand drivers for use. METHODS: A mixed methods study was used with doctors in a paediatric and adult teaching hospital in 2013. A paper based survey examined mobile device usage data by doctors in the clinical setting. Focus groups explored doctors' reasons for using or refraining from using mobile devices in the clinical setting, and their attitudes about others' use. RESULTS: The survey, completed by 109 doctors, showed that 91% owned a smartphone and 88% used their mobile devices frequently in the clinical setting...
December 7, 2016: Internal Medicine Journal
https://www.readbyqxmd.com/read/27925380/angiotensin-converting-enzyme-2-polymorphisms-and-postexercise-hypotension-in-hypertensive-medicated-individuals
#17
Karla F Goessler, Marcos D Polito, Gloria de F Mota, Edilamar M de Oliveira, Véronique A Cornelissen
The renin-angiotensin aldosterone system (RAAS) is associated with diverse physiological responses and adaptations to exercise. The angiotensin converting enzyme (ACE) 2 has vasodilatory effects, which might be associated with the blood pressure (BP) responses to acute exercise. The aim of this study was to investigate the role of ACE2 polymorphisms in postexercise hypotension (PEH). Thirty-four medicated hypertensive (61·3 ± 1·7 years, 76·1 ± 2·7 kg, 160 ± 1·6 cm) men (n = 12) and women (n = 22), participated in a control and a moderate intensity exercise session in a randomized order...
December 7, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27925340/evaluation-of-epididymis-storage-temperature-and-cryopreservation-conditions-for-improved-mitochondrial-membrane-potential-membrane-integrity-sperm-motility-and-in-vitro-fertilization-in-bovine-epididymal-sperm
#18
M Nichi, T Rijsselaere, Jda Losano, Dsr Angrimani, Gkv Kawai, Igf Goovaerts, A Van Soom, V H Barnabe, Jbp De Clercq, Pej Bols
The maintaining of the epididymis at lower temperatures during storage and transport improves sperm quality. Our study aimed to test whether epididymis storage temperature (post-mortem) and sperm cryopreservation affect sperm kinetics, membrane integrity, mitochondrial potential and fertility capacity. Thirty-six epididymides were collected from 18 bulls after slaughter and divided into two groups: at 4 or 34°C for 2-3 hr. The sperm was collected from the epididymis cauda. The evaluation consisted of computer-assisted sperm analysis (CASA), SYBR14/PI/JC1 to evaluate membrane integrity, mitochondrial membrane potential (MMP) and measurement of lipid peroxidation (TBARS)...
December 7, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27925332/left-atrial-appendage-closure-with-the-new-occlutech%C3%A2-device-first-in-man-experience-and-neurological-outcome
#19
Barbara Bellmann, Steffen Schnupp, Peter Kühnlein, Christian Javernik, Caroline Kleinecke, Andreas Rillig, Ulf Landmesser, Johannes Brachmann, Jai-Wun Park
AIMS: Percutaneous left atrial appendage closure (LAAC) is a valuable treatment option for stroke prevention in patients with atrial fibrillation and a HAS-BLED-Score ≥ 3. Determinants of procedural safety events and neurological outcome of the patients with the Occlutech Device (OD) are not established yet. METHODS AND RESULTS: Between 2012 and 2016, 30 patients underwent LAAC using the OD. This is a prospective, study. Neurological examination and transesophageal echocardiography was performed directly before and after the procedure and after 1, 3 and 12 months...
December 7, 2016: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/27925320/three-dimensional-fibrous-network-of-na0-21mno2-for-aqueous-sodium-ion-hybrid-supercapacitor
#20
Natarajan Karikalan, Chelladurai Karuppiah, Shen-Ming Chen, Murugan Velmurugan, Periyasami Gnanaprakasam
Sodium ion hybrid supercapacitors are the potential energy storage devices and recently received an enormous interest. However, the development of desired cathode material and the use of non-aqueous electrolyte remains a great challenge. Hence, we developed the aqueous Na-ion hybrid supercapacitor based on three dimensional fibrous network of NaMnO2. The described cathode material was synthesized by the electro-oxidation of potassium manganese hexacyanoferrate (KMnHCF) nanocubes. The oxidized compound was confirmed as Na0...
December 7, 2016: Chemistry: a European Journal
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