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https://www.readbyqxmd.com/read/28513877/heart-rate-and-outcome-in-heart-failure-with-reduced-ejection-fraction-differences-between-atrial-fibrillation-and-sinus-rhythm-a-cibis-ii-analysis
#1
Bart A Mulder, Kevin Damman, Dirk J Van Veldhuisen, Isabelle C Van Gelder, Michiel Rienstra
BACKGROUND: Heart rate has been associated with prognosis in patients with heart failure with reduced ejection fraction (HFREF) and sinus rhythm; whether this also holds true in patients with atrial fibrillation (AF) is unknown. HYPOTHESIS: To evaluate cardiac rhythm and baseline heart rate and the influence of outcome in patients with HFREF enrolled in the Cardiac Insufficiency Bisoprolol Study II. METHODS: In total, 2539 patients were stratified according to their baseline heart rhythm (AF or sinus rhythm) and into quartiles of heart rate (≤70 bpm, 71-78 bpm, 79-90 bpm, and >90 bpm)...
May 17, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28511417/effectiveness-of-a-four-week-diet-regimen-exercise-and-psychological-intervention-for-weight-loss
#2
Tobias Weinreich, Hans-Peter Filz, Ursula Gresser, Barbara M Richartz
INTRODUCTION: Obesity is accompanied by restriction in the quality of life and an increased risk of morbidity and mortality. Cardiovascular, orthopedic, and metabolic disorders are among the possible consequences. In the management of obesity, a combination therapy that includes dietary, exercise, and behaviour modules has proven its worth. AIM: To evaluate the effect of weight-associated parameters, circulation associated parameters, glucose metabolism, body composition and life quality changes within a four-week inpatient rehabilitation program...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510737/total-haemoglobin-mass-but-not-haemoglobin-concentration-is-associated-with-preoperative-cardiopulmonary-exercise-testing-derived-oxygen-consumption-variables
#3
J M Otto, J O M Plumb, D Wakeham, E Clissold, L Loughney, W Schmidt, H E Montgomery, M P W Grocott, T Richards
Background: Cardiopulmonary exercise testing (CPET) measures peak exertional oxygen consumption ( V˙O2peak ) and that at the anaerobic threshold ( V˙O2 at AT, i.e. the point at which anaerobic metabolism contributes substantially to overall metabolism). Lower values are associated with excess postoperative morbidity and mortality. A reduced haemoglobin concentration ([Hb]) results from a reduction in total haemoglobin mass (tHb-mass) or an increase in plasma volume. Thus, tHb-mass might be a more useful measure of oxygen-carrying capacity and might correlate better with CPET-derived fitness measures in preoperative patients than does circulating [Hb]...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28495263/tobacco-use-among-people-living-with-hiv-analysis-of-data-from-demographic-and-health-surveys-from-28-low-income-and-middle-income-countries
#4
Noreen D Mdege, Sarwat Shah, Olalekan A Ayo-Yusuf, James Hakim, Kamran Siddiqi
BACKGROUND: Tobacco use among people living with HIV results in excess morbidity and mortality. However, very little is known about the extent of tobacco use among people living with HIV in low-income and middle-income countries (LMICs). We assessed the prevalence of tobacco use among people living with HIV in LMICs. METHODS: We used Demographic and Health Survey data collected between 2003 and 2014 from 28 LMICs where both tobacco use and HIV test data were made publicly available...
June 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28494549/-changes-in-the-composition-of-intestinal-microbiota-in-mice-with-acute-liver-failure-induced-by-d-galactosamine
#5
Y X Hu, L Yu, H J Liu, M L Cheng
Objective: To investigate the changes in the composition of intestinal microbiota in mice with acute liver failure and identify characteristic bacteria, and to provide a basis for the diagnosis and treatment of acute liver failure with intestinal microbiota disorders. Methods: A total of 30 specific pathogen-free male BALB/c mice were used in this study, including 25 mice in the model group and 5 mice in the control group. An acute liver failure model was induced by D-galactosamine. Microbial DNA was extracted from intestinal contents in different segments of the lower digestive tract (ileum and colon) and feces and then were amplified using PCR...
April 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28447032/risk-of-sleepiness-related-accidents-in-switzerland-results-of-an-online-sleep-apnea-risk-questionnaire-and-awareness-campaigns
#6
Mona Lichtblau, Daniel Bratton, Philippe Giroud, Thomas Weiler, Konrad E Bloch, Thomas Brack
OBJECTIVES: Obstructive sleep apnea syndrome (OSAS) is associated with major morbidity and mortality but OSAS is frequently under recognized. To promote awareness of OSAS, the Swiss Lung League launched an online questionnaire combined with annual advertisements in mass media. Characteristics of participants, prevalence of sleep apnea, OSAS-related symptoms, and their association with accidents were investigated. METHODS: A questionnaire was created incorporating anthropometrics, the Epworth sleepiness scale (ESS), the OSAS domain of the sleep disorders questionnaire (SDQ), and a question on accidents related to sleepiness...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28437534/association-of-mortality-with-the-death-of-a-sibling-in-childhood
#7
Yongfu Yu, Zeyan Liew, Sven Cnattingius, Jørn Olsen, Mogens Vestergaard, Bo Fu, Erik Thorlund Parner, Guoyou Qin, Naiqing Zhao, Jiong Li
Importance: The death of a close relative is associated with an increased mortality risk among the bereaved, but much less is known about the potential association of the death of a sibling in childhood with mortality in this population. Objective: To examine the association between sibling death in childhood and subsequent mortality risk. Design, Setting, and Participants: This population-based cohort study of 5 005 029 participants evaluated linked national registers in Denmark (January 1, 1973, through December 31, 2009) and Sweden (January 1, 1973, through December 31, 2008)...
April 24, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28424565/invasive-pneumococcal-disease-still-lots-to-learn-and-a-need-for-standardized-data-collection-instruments
#8
T J Marrie, G J Tyrrell, Sumit R Majumdar, Dean T Eurich
Background. Large studies of invasive pneumococcal disease (IPD) are frequently lacking detailed clinical information. Methods. A population-based 15-year study of IPD in Northern Alberta. Results. 2435 patients with a mean age of 54.2 years formed the study group. Males outnumbered females and Aboriginal and homeless persons were overrepresented. High rates of smoking, excessive alcohol use, and illicit drug use were seen. Almost all (87%) had a major comorbidity and 15% had functional limitations prior to admission...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28373784/left-ventricular-noncompaction-a-rare-form-of-cardiomyopathy-revelation-modes-and-predictors-of-mortality-in-adults-through-23-cases
#9
Iliyasse Asfalou, Sanae Boulaamayl, Maha Raissouni, Najat Mouine, Mohamed Sabry, Jamal Kheyi, Nawal Doghmi, Aatif Benyass
OBJECTIVES: To describe modes of clinical presentation and echocardiographic, angiographic, and rhythmic features, and prognostic characteristics of left ventricular noncompaction cardiomyopathy (LVNC) in North African adults, through one of the first series in Morocco. BACKGROUND: LVNC is a rare congenital disorder, described for the first time by Engberding in 1984. The suspected diagnosis in thromboembolic, hemodynamic, or rhythm events requires both echocardiography and cardiovascular magnetic resonance (CMR)...
April 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28350475/occupational-radiation-exposure-and-deaths-from-malignant-intracranial-neoplasms-of-the-brain-and-cns-in-u-s-radiologic-technologists-1983-2012
#10
Cari M Kitahara, Martha S Linet, Stephen Balter, Donald L Miller, Preetha Rajaraman, Elizabeth K Cahoon, Raquel Velazquez-Kronen, Steven L Simon, Mark P Little, Michele M Doody, Bruce H Alexander, Dale L Preston
OBJECTIVE: Childhood exposure to acute, high-dose radiation has consistently been associated with risk of benign and malignant intracranial tumors of the brain and CNS, but data on risks of adulthood exposure to protracted, low-to-moderate doses of radiation are limited. In a large cohort of radiologic technologists, we quantified the association between protracted, low-to-moderate doses of radiation and malignant intracranial tumor mortality. MATERIALS AND METHODS: The study population included 83,655 female and 26,642 male U...
March 28, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28320041/prevention-of-iron-overload-and-long-term-maintenance-of-normal-iron-stores-in-thalassaemia-major-patients-using-deferiprone-or-deferiprone-deferoxamine-combination
#11
Annita Kolnagou, Christina N Kontoghiorghe, George J Kontoghiorghes
Decrease in mortality and morbidity is observed in thalassaemia major patients with reduced iron load in comparison to heavy iron loaded patients. Effective and complete treatment of transfusional iron overload can be achieved by chelation protocols that can eliminate excess iron and maintain normal iron stores (NIS). The maintenance of NIS, i. e., serum ferritin (350 μg/L >), MRI T2* cardiac (>20 ms) and liver (>6.3 ms) relaxation time levels was monitored in 16 thalassaemia major patients (32-53 years, 12 splenectomized, 10 male, erythrocyte transfusions 120-323 ml/kg/year) for about 90 patient years...
March 20, 2017: Drug Research
https://www.readbyqxmd.com/read/28301070/substance-use-disorders-and-the-risk-of-suicide-mortality-among-men-and-women-in-the-us-veterans-health-administration
#12
Kipling M Bohnert, Mark A Ilgen, Samantha Louzon, John F McCarthy, Ira R Katz
BACKGROUND AND AIMS: Limited information is available regarding links between specific substance use disorders (SUDs) and suicide mortality; however, the preliminary evidence that is available suggests that suicide risk associated with SUDs may differ for men and women. This study aimed to estimate associations between SUDs and suicide for men and women receiving Veterans Health Administration (VHA) care. DESIGN: A cohort study using national administrative health records...
March 16, 2017: Addiction
https://www.readbyqxmd.com/read/28283367/prevalence-and-predictors-of-sleep-apnea-risk-among-ghanaian-stroke-survivors
#13
Fred Stephen Sarfo, Carolyn Jenkins, Nathaniel Adusei Mensah, Raelle Saulson, Osei Sarfo-Kantanka, Arti Singh, Michelle Nichols, Suparna Qanungo, Bruce Ovbiagele
BACKGROUND AND PURPOSE: Sleep apnea (SA) has emerged as a potent risk factor for stroke recurrence and mortality. The burden of SA among stroke survivors in sub-Saharan Africa where stroke incidence and mortality are escalating is unknown. We sought to assess the prevalence of SA risk and its clinical correlates and predictors among Ghanaian stroke survivors. METHODS: This cross-sectional study involved 200 consecutive stroke survivors attending a neurology clinic in a tertiary medical center in Kumasi, Ghana...
March 7, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28282529/evidence-of-socio-economic-stress-and-female-foeticide-in-racial-disparities-in-the-gender-ratio-at-birth-in-the-united-states-1995-2014
#14
Victor Grech
BACKGROUND: Males are born in excess of females, expressed as M/T (male/total births), which is expected to approximate 0.515. Racial M/T disparities have been long known. This study was carried out in order to identify such disparities in different races in the United States. DESIGN: Monthly male and female live births by race for the entire US were obtained from the website of the Centers for Disease Control and Prevention for 1995-2014 for the four racial groups: American Indian or Alaska Native, Asian or Pacific Islander, Black or African American and White...
March 2017: Early Human Development
https://www.readbyqxmd.com/read/28274032/disseminated-intravascular-coagulation-and-excessive-fibrinolysis-dic-xfl-syndrome-in-prostate-cancer-a-rare-complicated-disorder
#15
Azhar Bin Amir Hamzah, Yew Maw Choo, Mohamed Azmi Hassali, Fahad Saleem, Ashutosh Kumar Verma
Disseminated Intravascular Coagulation (DIC) develops in patient with prostate cancer, which is manifested by systemic, intracranial, intracavitary or intracutaneous bleeding indicating uncompensated or excessive fibrinolysis (XFL). This case report is a description of a 61-year-old male with metastatic prostate cancer that progressed to manifest DIC. The condition is rare in clinical practice, and even rarer when is coupled with XFL. Treatment was mainly replenishing coagulation factors, platelets and controlling the disease progression with aggressive hormonal therapy...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28260748/effect-of-obesity-on-fasting-blood-sugar
#16
R Akter, A Nessa, M F Husain, F Wahed, N Khatun, M Yesmin, S Nasreen, T Tajkia
Obesity is a disorder of body weight regulatory systems characterized by an accumulation of excess body fat. World Heath Organization recommended that 66% of deaths now occur in developing countries and recognizes obesity as a leading risk factor. Obesity is associated with chronic, low grade, systemic inflammation. The inflammatory state plays a causal role in the development of insulin resistance, type 2 diabetes and the metabolic syndrome. This study will design to evaluate the relation between obesity with fasting blood sugar (FBS)...
January 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28258132/mortality-in-graves-orbitopathy-is-increased-and-influenced-by-gender-age-and-pre-existing-morbidity-a-nationwide-danish-register-study
#17
Charlotte F Schwensen, Frans Brandt, Laszlo Hegedüs, Thomas H Brix
INTRODUCTION: It is unclear whether the excess mortality associated with Graves' disease differs between individuals with Graves' orbitopathy (GO) or without (GD). SUBJECTS AND METHODS: A nationwide, register-based cohort study in which all adult Danes diagnosed with GD (n = 28 461) and GO (n = 3965) between 1995 and 2012 were matched for age and gender with four control subjects. Median follow-up time was 7.9 years (range 0-17.5). Mortality risk in GO patients compared to the control population and compared to GD patients was calculated using Cox regression analyses, adjusting for pre-existing morbidity using the Charlson score...
June 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28246150/changes-in-the-management-and-comorbidities-of-acromegaly-over-three-decades-the-french-acromegaly-registry
#18
MULTICENTER STUDY
Luigi Maione, Thierry Brue, Albert Beckers, Brigitte Delemer, Patrick Petrossians, Françoise Borson-Chazot, Olivier Chabre, Patrick François, Jérôme Bertherat, Christine Cortet-Rudelli, Philippe Chanson
CONTEXT: Acromegaly is a rare disease associated with chronic multisystem complications. National registries have been created in several countries. DESIGN: The French Registry contains data on acromegaly epidemiology, management and comorbidities recorded over more than three decades, retrospectively until 1999 and prospectively from 1999 to 2012. RESULTS: Data could be analyzed for 999 of the 1034 patients included in the registry (46% males)...
May 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28223429/cancer-mortality-in-hispanic-ethnic-groups
#19
Paulo S Pinheiro, Karen E Callahan, Rebecca L Siegel, Hongbin Jin, Cyllene R Morris, Edward J Trapido, Scarlett Lin Gomez
Background: Cancer is the leading cause of death among Hispanics. The burden of cancer mortality within Hispanic groups has not been well quantified.Methods: Cancer mortality rates for 2008-2012 in Florida were computed on the basis of race, ethnicity, and birthplace, specifically focusing on major Hispanic groups-Mexicans, Puerto Ricans, Cubans, Central Americans, South Americans, and Dominicans. Age-adjusted mortality rate ratios derived from negative binomial regression were used to compare Hispanics, aggregated and by group, to nonHispanic whites (NHW)...
March 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28209242/survival-of-macrovascular-disease-chronic-kidney-disease-chronic-respiratory-disease-cancer-and-smoking-in-patients-with-type-2-diabetes-biobank-japan-cohort
#20
Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata
BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities. METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007...
March 2017: Journal of Epidemiology
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