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https://www.readbyqxmd.com/read/29788135/the-hepatic-glucocorticoid-receptor-is-crucial-for-cortisol-homeostasis-and-sepsis-survival-in-humans-and-male-mice
#1
Marc Jenniskens, Ruben Weckx, Thomas Dufour, Sarah Vander Perre, Lies Pauwels, Sarah Derde, Arno Téblick, Fabian Güiza, Greet Van den Berghe, Lies Langouche
Sepsis is hallmarked by hypercortisolemia, a stress response that is essential for survival. This elevation in plasma cortisol is partially brought about by suppressed hepatic cortisol breakdown. We now demonstrated that a controlled downregulation of the hepatic glucocorticoid receptor (hepatic GR) is crucial herein. In a mouse model of fluid-resuscitated, antibiotic-treated abdominal sepsis and in human ICU patients, sepsis reduced hepatic GR expression and signaling, but increased (free) plasma cortisol/corticosterone, explained by suppressed cortisol/corticosterone binding proteins and A-ring-reductases...
May 17, 2018: Endocrinology
https://www.readbyqxmd.com/read/29755810/evaluation-of-traffic-accident-risk-in-in-city-bus-drivers-the-use-of-berlin-questionnaire
#2
Mehmet Sezai Taşbakan, Pervin Korkmaz Ekren, Funda Elmas Uysal, Özen K Başoğlu
OBJECTIVES: Traffic accidents associated with high mortality rate may produce serious problems especially in highways. Obstructive sleep apnea (OSA) has been associated with a high risk for traffic accidents due to excessive daytime sleepiness even in in-city drivers. In the present study, it was aimed to evaluate the rate of OSA symptoms and to identify risk factors associated with traffic accidents in in-city bus drivers. MATERIAL AND METHODS: A self-administered questionnaire including demographic and anthropometric features, sleep and work schedules, Berlin questionnaire, Epworth sleepiness score (ESS), and history of traffic accidents was used...
April 2018: Turkish Thoracic Journal
https://www.readbyqxmd.com/read/29751966/outcomes-in-nursing-home-patients-with-traumatic-brain-injury
#3
Stephanie N Lueckel, Cyrus M Kosar, Joan M Teno, Sean F Monaghan, Daithi S Heffernan, William G Cioffi, Kali S Thomas
BACKGROUND: Traumatic brain injury is a leading cause of death and disability in the United States. In survivors, traumatic brain injury remains a leading contributor to long-term disability and results in many patients being admitted to skilled nursing facilities for postacute care. Despite this very large population of traumatic brain injury patients, very little is known about the long-term outcomes of traumatic brain injury survivors, including rates of discharge to home or risk of death in long-term nursing facilities...
May 9, 2018: Surgery
https://www.readbyqxmd.com/read/29741136/mortality-and-its-predictors-in-patients-with-rheumatoid-arthritis-a-danish-population-based-inception-cohort-study
#4
J K Pedersen, R Holst, J Primdahl, A J Svendsen, K Hørslev-Petersen
OBJECTIVES: To investigate mortality and its predictors in a retrospectively defined population-based rheumatoid arthritis (RA) inception cohort Method: We included patients ascertained with incident RA from a region in the southern part of Denmark from 1995 to 2002. All patients fulfilled the 1987 American College of Rheumatology criteria for RA. The patients were followed from RA classification until death, emigration, or end of follow-up on 31 December 2013. We used personal record linkage with national public registers to obtain information on education, employment, cohabitation, comorbidity, and vital status...
May 9, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29715703/icu-readmission-after-cardiac-surgery-still-a-matter-of-concern
#5
Philipp Kolat, Patricia Guttenberger, Michael Ried, Julia Kapahnke, Assad Haneya, Christof Schmid, Claudius Diez
BACKGROUND:  Despite improvements in diagnostics and perioperative care, readmission to intensive care unit (ICU) after cardiac surgery is still a severe drawback for patients with considerable morbidity, mortality, and costs. Aim of this retrospective analysis was to disentangle independent risk factors for ICU readmission. MATERIAL AND METHODS:  Between 01/2004 and 12/2012, 336 out of 9,555 (3.5%) patients undergoing cardiac surgery at the Department of Cardiothoracic Surgery in Regensburg (Germany) were readmitted to ICU...
May 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29704269/genotype-guided-warfarin-dosing-versus-conventional-dosing-strategies-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#6
Gary Tse, Mengqi Gong, Guangping Li, Sunny Hei Wong, William K K Wu, Wing Tak Wong, Leonardo Roever, Alex Pui Wai Lee, Gregory Y H Lip, Martin C S Wong, Tong Liu
BACKGROUND: Previous trials on the effectiveness of genotype-guided warfarin dosing versus conventional dosing have been inconclusive. We conducted a systematic review and meta-analysis of randomized trials comparing genotype-guided to conventional dosing strategies. METHODS: PubMed and Cochrane Library were searched until 23rd October 2017. RESULTS: A total of 76 and 94 entries were retrieved. A total of 2626 subjects in the genotype-guided dosing (mean age: 63...
April 28, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29665562/10-year-cvd-risk-in-han-chinese-mainland-patients-with-schizophrenia
#7
Shuai Zhao, HaiLong Xia, JingJing Mu, Long Wang, Li Zhu, AnZhen Wang, XiaoQin Zhou
People with schizophrenia have a shortened life expectancy, with cardiovascular disease (CVD) being the primary contributor to this excessive mortality. A total of 466 inpatients with schizophrenia and 507 healthy community controls in the Chinese mainland were recruited in this study. Sociodemographic information, medical history, and smoking history were recorded. In addition, total cholesterol (TC), fasting blood glucose (FBG), triglycerides (TG), and high-destiny lipoprotein cholesterol (HDL-C) were analyzed...
April 9, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29656787/fifty-year-incidence-of-waldenstr%C3%A3-m-macroglobulinemia-in-olmsted-county-minnesota-from-1961-through-2010-a-population-based-study-with-complete-case-capture-and-hematopathologic-review
#8
Robert A Kyle, Dirk R Larson, Ellen D McPhail, Terry M Therneau, Angela Dispenzieri, Shaji Kumar, Prashant Kapoor, James R Cerhan, S Vincent Rajkumar
OBJECTIVE: To determine the incidence of Waldenström macroglobulinemia (WM) in a strictly defined geographic area over a 50-year period. PATIENTS AND METHODS: All residents of Olmsted County with a diagnosis of WM, consisting of a monoclonal IgM protein of any size and/or 10% or more lymphoplasmacytic infiltration of the bone marrow along with anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly requiring therapy, were identified from January 1, 1961, to December 31, 2010...
April 12, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29628667/early-predictive-factors-of-hypofibrinogenemia-in-acute-trauma-patients
#9
Shahram Paydar, Behnam Dalfardi, Zahra Shayan, Leila Shayan, Jalal Saem, Shahram Bolandparvaz
Background: Uncontrolled hemorrhage still remains a major cause of trauma-associated mortality. The events resulting in acute traumatic coagulopathy, particularly hypofibrinogenemia, make control of bleeding difficult. It is essential to timely predict, diagnose, and manage trauma-induced coagulopathy. Aims: The aim of this study is to determine clinical and easily available laboratory variables that are predictive of hypofibrinogenemia in acute trauma patients...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29627377/fgf21-a-liver-hormone-that-inhibits-alcohol-intake-in-mice-increases-in-human-circulation-after-acute-alcohol-ingestion-and-sustained-binge-drinking-at-oktoberfest
#10
Susanna Søberg, Emilie S Andersen, Niels B Dalgaard, Ida Jarlhelt, Nina L Hansen, Nina Hoffmann, Tina Vilsbøll, Anne Chenchar, Michal Jensen, Trisha J Grevengoed, Sam A J Trammell, Filip K Knop, Matthew P Gillum
OBJECTIVE: Excessive alcohol consumption is a leading cause of global morbidity and mortality. However, knowledge of the biological factors that influence ad libitum alcohol intake may be incomplete. Two large studies recently linked variants in the KLB locus with levels of alcohol intake in humans. KLB encodes β-klotho, co-receptor for the liver-derived hormone fibroblast growth factor 21 (FGF21). In mice, FGF21 reduces alcohol intake, and human Fgf21 variants are enriched among heavy drinkers...
March 27, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29617927/estimating-counterfactual-risk-under-hypothetical-interventions-in-the-presence-of-competing-events-crystalline-silica-exposure-and-mortality-from-two-causes-of-death
#11
Andreas M Neophytou, Sally Picciotto, Daniel M Brown, Lisa E Gallagher, Harvey Checkoway, Ellen A Eisen, Sadie Costello
Exposure to silica has been linked to excess risk of lung cancer and non-malignant respiratory disease mortality. In this study we estimated risk for both these outcomes in relation to occupational silica exposure as well as the reduction in risk that would result from hypothetical interventions on exposure in a cohort of exposed workers. Analyses were carried out in an all-male study population consisting of 2342 California diatomaceous earth workers regularly exposed to crystalline silica, followed between 1942 and 2011...
April 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29607559/neck-hematoma-after-major-head-and-neck-surgery-risk-factors-costs-and-resource-utilization
#12
Shivani Shah-Becker, Erin K Greenleaf, Melissa M Boltz, Christopher S Hollenbeak, Neerav Goyal
BACKGROUND: Postoperative cervical hematoma after major head and neck surgery is a feared complication. However, risk factors for developing this complication and attributable costs are not well-established. METHODS: The Nationwide Inpatient Sample database was utilized compare patients with and without postoperative cervical hematoma. Logistic regression was used to analyze risk factors for hematoma formation and 30-day mortality. Total inpatient length of stay (LOS) and costs were fit to generalized linear models...
April 1, 2018: Head & Neck
https://www.readbyqxmd.com/read/29587543/iron-overdose-epidemiology-clinical-features-and-iron-concentration-effect-relationships-the-uk-experience-2008-2017
#13
D Nicholas Bateman, Victoria Eagling, Euan A Sandilands, Gill Jackson, Catherine Crawford, Leonard Hawkins, Ted Cheung, Gillian Cooper, Sally M Bradberry, John P Thompson, Simon H L Thomas, Michael Eddleston
BACKGROUND: Iron poisoning is potentially serious, but mortality has fallen worldwide since implementation of pack size and packaging restrictions, and changes in iron use during pregnancy. The management of individual cases of overdose remains problematic due to uncertainty about indications for antidote. We examine the epidemiology of iron overdose in hospital cases referred to the UK National Poisons Information Service (NPIS) and evaluate the toxicokinetics of iron in patients ingesting only iron preparations...
March 28, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29580222/drug-related-deaths-in-scotland-1979-2013-evidence-of-a-vulnerable-cohort-of-young-men-living-in-deprived-areas
#14
Jane Parkinson, Jon Minton, James Lewsey, Janet Bouttell, Gerry McCartney
BACKGROUND: Even after accounting for deprivation, mortality rates are higher in Scotland relative to the rest of Western Europe. Higher mortality from alcohol- and drug-related deaths (DRDs), violence and suicide (particularly in young adults) contribute to this 'excess' mortality. Age-period and cohort effects help explain the trends in alcohol-related deaths and suicide, respectively. This study investigated whether age, period or cohort effects might explain recent trends in DRDs in Scotland and relate to exposure to the changing political context from the 1980s...
March 27, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29573101/improving-life-expectancy-of-patients-with-scleroderma-results-from-the-south-australian-scleroderma-register
#15
Nicholas Kennedy, Jenny Walker, Paul Hakendorf, Peter Roberts-Thomson
BACKGROUND: Scleroderma is a rare connective tissue disorder characterised by inflammation, vasculopathy and excessive fibrosis. Patients with scleroderma are known to have decreased life expectancy. AIM: To investigate changes in life expectancy in patients with scleroderma over a 30 year period. METHOD: Utilizing the South Australian Scleroderma Register (SASR), deceased patients were identified. We examined changes in age of death and duration of disease in these patients over 3 time periods 1985-94, 1995-2004 and 2005-2015...
March 23, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29572708/klinefelter-syndrome-insulin-resistance-metabolic-syndrome-and-diabetes-review-of-literature-and-clinical-perspectives
#16
REVIEW
Andrea Salzano, Roberta D'Assante, Liam M Heaney, Federica Monaco, Giuseppe Rengo, Pietro Valente, Daniela Pasquali, Eduardo Bossone, Daniele Gianfrilli, Andrea Lenzi, Antonio Cittadini, Alberto M Marra, Raffaele Napoli
PURPOSE: Klinefelter syndrome (KS), the most frequent chromosomic abnormality in males, is associated with hypergonadotropic hypogonadism and an increased risk of cardiovascular diseases (CVD). The mechanisms involved in increasing risk of cardiovascular morbidity and mortality are not completely understood. This review summarises the current understandings of the complex relationship between KS, metabolic syndrome and cardiovascular risk in order to plan future studies and improve current strategies to reduce mortality in this high-risk population...
March 23, 2018: Endocrine
https://www.readbyqxmd.com/read/29559805/moderate-glucose-supply-reduces-hemolysis-during-systemic-inflammation
#17
Johannes Jägers, Stephan Brauckmann, Michael Kirsch, Katharina Effenberger-Neidnicht
Background: Systemic inflammation alters energy metabolism. A sufficient glucose level, however, is most important for erythrocytes, since erythrocytes rely on glucose as sole source of energy. Damage to erythrocytes leads to hemolysis. Both disorders of glucose metabolism and hemolysis are associated with an increased risk of death. The objective of the study was to investigate the impact of intravenous glucose on hemolysis during systemic inflammation. Materials and methods: Systemic inflammation was accomplished in male Wistar rats by continuous lipopolysaccharide (LPS) infusion (1 mg LPS/kg and h, 300 min)...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29558066/excess-male-infant-mortality-the-gene-institution-interactions
#18
Roland Pongou, Barthelemy Kuate Defo, Zacharie Tsala Dimbuene
No abstract text is available yet for this article.
May 2017: American Economic Review
https://www.readbyqxmd.com/read/29534076/excess-mortality-and-hospitalizations-in-transitional-age-youths-with-a-long-term-disease-a-national-population-based-cohort-study
#19
Antoine Rachas, Philippe Tuppin, Laurence Meyer, Bruno Falissard, Albert Faye, Nizar Mahlaoui, Elise de La Rochebrochard, Marie Frank, Pierre Durieux, Josiane Warszawski
INTRODUCTION: The number of adolescents with a severe chronic disease has increased in high-income countries due to improvements in the prognosis of childhood-onset chronic conditions. The transition from childhood to adulthood is a critical period that may be associated with increased mortality and morbidity. We aimed to estimate the prevalence of adolescents with a long-term disease (LTD) in France and assess their mortality and hospitalization risks relative to the general population...
2018: PloS One
https://www.readbyqxmd.com/read/29530619/o-glcnacylation-of-cardiac-nav1-5-contributes-to-the-development-of-arrhythmias-in-diabetic-hearts
#20
Peng Yu, Lili Hu, Jinyan Xie, Sisi Chen, Lin Huang, Zixuan Xu, Xiao Liu, Qiongqiong Zhou, Ping Yuan, Xia Yan, Jiejin Jin, Yang Shen, Wengen Zhu, Linghua Fu, Qi Chen, Jianhua Yu, Jianxin Hu, Qing Cao, Rong Wan, Kui Hong
BACKGROUND: Cardiovascular complications are major causes of mortality and morbidity in diabetic patients. The mechanisms underlying the progression of diabetic heart (DH) to ventricular arrhythmias are unclear. O-linked GlcNAcylation (O-GlcNAc) is a reversible post-translational modification for the regulation of diverse cellular processes. The purpose of this study was to assess whether the cardiac voltage-gated sodium channel (Nav1.5) is subjected to O-linked GlcNAcylation (O-GlcNAc), which plays an essential role in DH-induced arrhythmias...
June 1, 2018: International Journal of Cardiology
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